lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MAASRVFAQRLASTMKVARPAARIQARTLTTQRMATPFQTIKRQQPSMIQASARQAFAARRQYSSEIADAMVQVSQNIGMGSAAIGLGGAGIGIGVVFGSLLLAVSRNPALRGQLFSYAILGFAFVEAIGLFDLMVAMMCKYV
The following text describes a protein:
Function:
The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MSAPQVVSCGSYDIVLGSSLLQSRFVAEDLLQRLPSTATFVILTDANVGPLYAEPLRVQLAALLHAQGNTTRRVLLHAIPSGEASKCREMKAKIEDEVLFPNRCHRDTCIVAVGGGVVGDLSGYVASTYMRGVPFVQVPTSLLACVDSSIGGKTGIDVEAGKNLLGAFHMPQRVYIDLSVLHTLPKRELINGMGEVVKSGAIFNAELFELLETSAESILALSDMDLVQRVVALTVQVKATVVTQDTKEMGLRAILNFGHSIGHGIEALVQPEYLHGECVSMGCIKEAEIARGMGVCSSATVGRLRRCLASYGLPVRVPEHVATRDVLVKMEVDKKNSQGVKKIVLLEKIGKVLADPYARAVKDHQIELVLEKQVRMVPGAKANGTIRVPGSKSISNRVLLMAALGKGACRITGLLHSDDTQVMMTALQKVGAKFSWEDNGAVLVVEGTAGKFATVADGEEIYLSNAGTAARFLTSAMTLVPSENDGTVVVTGNYRMKERPIAPLVEALRGNGCDISYLETEGCPPLAIRGTGLRGGTVRLAAKVSSQYVSSVLISAPYAKEPLVLELDEEQPTSLPYILMTTQLMQQFGIPVETLAPNRYRVPCGVYENPKEVSVEVDASSATYPLAFAAITGGQVTVEALGNTSLQGDAAFHTLLRSMGCTTTQDATSTTVIGPQDGTPLKAVDIDMETMTDAFMTAVALAAVADGTTKITGIANQRVKECNRIEVMVTELHKIGVECGELPDGIWIKGTAGKTDHLKQASIACHNDHRIAMSFAVLGSVVGNVVITDKECTDKTYPEFWDHVQMHLGLQVAPVVEETTDSNDSDTSIPGVFMIGMRGAGKSSLAKAASATLKLNLLDTDKVLEKEFGESIADFVARHNHTWEAFREKQKELLLRLIANPPPATIISCGGGVVETPEIVAALEKYPYVVHVHRDIRDVLAYLDTVEESHRPSLGDSHANVWARREPLYQRSATFEFVVTAGDVDYPRLDRDFVRFLSVITPGLPTNFDYRSSCRADTFFLSLTFPDMNDARPIISDISKGADALELRVDLLKYPQDTKFVAAQVALLRTLSSLPIIFTVRSKGQGGAFPDGEENELKMFELLQLGVRLGCEFVDMETCWSRKAREHLLAHRYRSAIISSFHAVQKPTSEAETKLIFRECYSQGRVQIVKVVVKAYSPQDALMVDRVAKDFANAWQQQMPIISLCTTEAGKLTRVLNRTLTPVTHPLLPAAAAPGQLSIEEIMILRKQLGLLPAREFFLFGSPIQKSPSPAMHNAGFESTSLSSLFTYGLHDTTDVLEIVKRMQAPDTCFGGGSVTIPLKVDIMAHLNELSPAARAIGAVNTIMREDRNGSPYWKGDNTDWLGILRPISKRLATLSVRKPAHELTALVVGAGGTSMAASYAMRQLGVGKLFIFNRTLEKAQAVAARFDAEALSELTPETLAQVDVVVGTIPAQAGFQLPDHLVAPRADGSKVVVLDAAYMPPITPMLAHAHASGGALCIQGYEMLYEQGIEQFYRWHKATQVWVVNEEAIKEACRQHVPIDQRLSQA
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MCIPRQKLTPRSSVDLFDIFGLSQKRKLTDVPFLIAFATCVVILMIVMMWTLCSSDTSRLAYGYVFKEFIDNLGIVAKVCCIGLGVSVTAIYWFRHFVDVFVWTMLVGVVLLTAVGVGYIWKGDENRFLITRILVTFAPLILTLCILVSRDRIKLIIRFYEDTIKTVFDMPLLLLLPLLTISCIILVVASCLFTFGLMYCDGNYNVGIIFAMVFVWIMMFWMVQFVLACHQIVISGVVARYYFTRDKCELVSPIYSSFYILIRYHLATHGKPLCQSGIRAVNLFICNLLTFVGMSWVGTFVFFTVKVLVVAVTTLIGYSMMVKDRPDDFEFYVVPVVIGAVFAFFCAHCFFVVFEIAFDTAFICYCEDYGLNNSTNEPFYATVEFHEKVKKAQEFTKDVEAKKTEE
The following text describes a protein:
Function:
Part of the ABC transporter complex ArtPIQM involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MFSDFLSLMFTAALMTLGLAVCSLLLGLFLSLIFAVLEANRFVGKPMTVFVALLRGLPEIIVVLLVYFGSTELVEMLTGEYIEFGAFGCGVLALSLIFAAYASQTLRGAIQAIPKGQWESGAALGLSKSYTFIHIVMPQVWRHALPGLSTQWLVLLKDTALVSLIGVDDLMHQADLINTNTHQPFTWYGIAALIYLAVTLISQVGIRKLELRFTRFERGVK
The following text describes a protein:
Function:
Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
Subcellular Localization:
Cytoplasm.
Sequence:
MQSHKILVVNAGSSSIKFQLFNDKKQVLAKGLCERIFIDGFFKLEFNQKKIEEKVQFNDHNLAVKHFLNALKKNKIITELSEIGLIGHRVVQGANYFTDAVLVDTHSLAKIKEFIKLAPLHNKPEADVIEIFLKEIKTAKNVAVFDTTFHTTIPRENYLYAVPENWEKNNLVRRYGFHGTSYKYINEFLEKKFNKKPLNLIVCHLGNGASVCAIKQGKSLNTSMGFTPLEGLIMGTRSGDIDPAIVSYIAEQQKLSCNDVVNELNKKSGMFAITGSSDMRDIFDKPEINDIAIKMYVNRVADYIAKYLNQLSGEIDSLVFTGGVGENASYCVQLIIEKVASLGFKTNSNLFGNYQDSSLISTNESKYQIFRVRTNEELMIVEDALRVSTNIKK
The following text describes a protein:
Function:
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
Sequence:
MSGNVQLLNDTLAAAKSEGRAALIAYLPAGFPTVTGGIEAVKAALDGGADVVEVGLPHSDPVLDGPVIQTADDIALRGGVRIADVMRTVREAHEATGKPILVMTYWNPIDRYGVERFTAELAEAGGAGCILPDLPVQESALWREHADKHGLATVFVVAPSSRDARLAEITAVGSGFVYAASLMGVTGTRASVGAQAEDLVRRTRATTDTPVCVGLGVSNAAQAAEVAGFADGVIVGSAFVKRMLDAPDDAAGLEGVRALAADLAKGVRGQA
The following text describes a protein:
Function:
Binds to decorin which may mediate the adherence of B.burgdorferi to collagen fibers in skin and other tissues.
Sequence:
MIKCNNKTFNNLLKLTILVNLLISCGLTGATKIRLERSAKDITDEIDAIKKDAALKGVNFDAFKDKKTGSGVSENPFILEAKVRATTVAEKFVIAIEEEATKLKETGSSGEFSAMYDLMFEVSKPLQKLGIQEMTKTVSDAAEENPPTTAQGVLEIAKKMREKLQRVHTKNYCTLKKKENSTFTDEKCKNN
The following text describes a protein:
Function:
Involved in endocytosis and clathrin cage assembly.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTYEKIVKGATKVKVAAPKPKYIEPILMATSLDHSLISKENFNTIMRTLQARLHDSSWSVVYKALIVIHLMIREGDKNVTLDYLSNQASPNLLNLNNNNIIKNSNSFNSDIKFITRYAKYLHTRVKQFESTGVDYVRDERSNNNTNQQGGRLRLLDVDKGLLREVESVQKQIDSLLKNNFMENEINNDIVLTAFRLLVNDLLALFQELNEGVINILEHYFEMSKIDAERSLKIYKKFVDQTKFVIDYLRVAKHLEYATKLHVPTIKHAPTALTSSLEEYLDDPNFEINRKQYLAEKKGKDNIVSKPTQSILNKKSKNEPGQQQQQPREQQQKLQGTSSDLNRHSSLVVQQTYNPWNTMFVPIVGVVDPSQQDQAQQQAQQQAQQQAQQQALQQQVQLQQAQQQALQQRATQQATQQQQQTLFSQLPSISQGKTLQSTFTGVGFGGYGSQPQQLQAQHTNPFIQPSQQLQQPQQPQQPIGLQRSNTNPFSSMATGQHQVSQQQFAQPYSQSNMNQQPQPLQAQSTNPFANTRFASTSHTTAFTLDNGSIQPQQQQQQQNQNQKIQANATGNNPFKVSQTTSQLFDNYASTQQQNQHQQLKPQATAGGLEHLPTIPVFPETQQEAQRQFYFQNAQTGLYNQAFQPQPQQQQQQQQQVQQYNYHDGPSLI
The following text describes a protein:
Function:
Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues. Phosphorylation of KHDRBS1 is EGF-dependent. Phosphorylates OTUB1, promoting deubiquitination of RPTOR.
Subcellular Localization:
Cytoplasm.
Sequence:
MEPFLRRRLAFLSFFWDKIWPAGGEPDHGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQRAQAKVCHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPRQDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGSPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLYEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKLHAIHRCHPR
The following text describes a protein:
Function:
Binds lipid bilayers, sequesters host endocytic organelles in the parasitophorous vacuole space, and causes their deformation and remodeling. Plays a role in nutrient acquisition from the host. In complex with ROP18, targets immunity-related GTPases (IRGs) to prevent IRG-mediated parasite killing by mouse cells. Important component within a kinase complex, contributing to phosphorylation of mouse IRGA6/IIGP1, an immunity-related GTPase that protects mice from infection by certain intracellular pathogens, by Toxoplasma gondii ROP5 and ROP18. Induces pro-inflammatory cytokine production in host macrophages. Activates host pro-inflammatory signaling pathways in a MyD88-dependent manner. Triggers generation of reactive oxygen species (ROS) in host cells. Activates MAPK pathway in host cells. Activates host NF-kappa-B signaling pathway by interacting with TRAF6 and modulating the 'Lys-63'-linked polyubiquitination of TRAF6.
Miscellaneous:
MISCELLANEOUS: Mice immunized against the protein produce specific antibodies, show predominant Th1-type immune profile in response to vaccination and survive longer after Toxoplasma challenge.
Subcellular Localization:
Secreted. Parasitophorous vacuole lumen. Parasitophorous vacuole membrane; Single-pass membrane protein. Cytoplasm. Host cytoplasm. Cytoplasmic vesicle, secretory vesicle. Note=Located in dense granules of tachyzoites. Upon infection, secreted into the parasitophorous vacuole. In bradyzoite-infected cells, localizes within the host cell cytoplasm.
Sequence:
MARHAIFSALCVLGLVAAALPQFATAATASDDELMSRIRNSDFFDGQAPVDSLRPTNAGVDSKGTDDHLTTSMDKASVESQLPRREPLETEPDEQEEVHFRKRGVRSDAEVTDDNIYEEHTDRKVVPRKSEGKRSFKDLLKKLALPAVGMGASYFAADRLVPELTEEQQRGDEPLTTGQNVGTVLGFAALAAAAAFLGMGLTRTYRHFSPRKNRSRQPALEQEVPESGEDGEDARQ
The following text describes a protein:
Function:
Involved in the regulation of vascular patterning in the stem, probably by negatively regulating the differentiation of vascular tissue.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGDEKPVIVMANRERDRELLIPVADSGDKDDGSSSKPSSSSSASSSSHQSSHETLSLFIRGWASKKFMTGCVILLPIAITFYITWWFIHFVDGFFSPIYAQLGINVFGFGFLTSIAFIFLVGVFMSSWLGASVLNLGEWFIKRMPFVRHIYNASKQISTAISPDQNTQAFKEVAIIRHPRVGEYAFGFITSTVVLQNYPTEEELCCVYVPTNHLYIGDILLVNSNDVIRPNLSVREGIEIVVSGGMSMPQILSTVDKPLASIDRATSL
The following text describes a protein:
Function:
Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.
Subcellular Localization:
Cytoplasm. Dynein axonemal particle.
Sequence:
MGTFEKLKELDLSRDEVERLGAALKKPEFRQLLADYVHEVQNPENRKLYEAEITQLERERGVAVTFINPSPGYVLKTSDGVRKCFINVCSCELIDRPTSAPMDKDGARGLQWRLPHSLTPPREDLDNKKARCEVYDVVFHPDVIHMAQKNHQFQEIVNKTACDAVEANFEVTLDKKNLKFPKLGYKGAPQSAIIRKPIKDFVPREMEETERQFYDKIYENADQKPKKTNVKRNVKKCAEGNSNYTTPKYVIKHRSHVDVQDCVEDKFARLNLTIPRELIVEINLPLLKASSDITLDVTEKTVQLTSEKPSKYKLNLTLPYRVNQDSGSAKFDKDLKKLIITLPVKRCELPRDDSGVESDPSPHSEDDVIEAKTPSFSDFRTNSCDYELPDFTCHLFDKTLAFTLNVRNVSQDSIEKQVTCDSLHLKFASLSSSFFESNYAFYVRIDSGLDPEKLSVETWDNNVVVQIPVNCDNLEYYYYGLSEHDLRKKYIEEPSVLNSVLQSPIPEEPEPEPEESVTPAINIANSYESSGDELSCSFSPRKGRGILKRLPNRSVSESSLDDMVASSIDDGEMSTSLKKTVRFNDVIMRQLYRSNSSILGQKKKNQRKARNKKRAQERRHSESEASEKEDEKREEKSDYIHSDIFDMDLGV
The following text describes a protein:
Function:
Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation (By similarity).
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein. Note=Vacuole and punctate structures.
Sequence:
MDIVATTQKELYGWYAYAWAAEPFMVVAVATYIPQLLQSYARQNAVLADDHSQPCDSPPVPFPGDPGVPTDPGIPPNNSLSSSVPWFLRANEIQLLESPDTVHTMKDHKAKPTQPTCVIKFFGIYIDTASFPLYTFSLSVLLQVVVVISMSGAADRGRFRKQLLLFFGIAGALTTGLFVFITPKRYYLGSFLAIVSNAAFGAATVCGNAYLPVLAAGMKDGTTSEEPSEPSTPSDTSKPASRSENTPLLSASGVDYETGESSNTAEIVKIDHRANVSARISGTGVALGYLAGFIVQIISIYLVITTGSTTWSLRLALLIVGVWWLIFQIPVLMWLKPRPGPPLPIKTDPQNHPWTATLDRVTNGGWSYVTYGWKTLLVTFKEARQMKDVALFLVGWFLVSDGITTINSTAVLFAQGELRMSPANLAVMGMLVVISGISGAKLTPLIGGTRASPIKSIVVVVSLAAAVPAYGILGFFFTNIGLKNPWELYVLAVWYGFALGGLNTVCRSTFSMLIPRGKEAVFFSLFSVTDKGSSVLGPLLVGLIVDKTHNLRHAFYLLLVLLITPIGLFLMIDMERGRKEAEYLETVEE
The following text describes a protein:
Function:
Plays a role in protein trafficking, actin organization and embryonic morphogenesis. Potentially acts as a cdc-42 effector. May play a role in hypodermal P-cell nuclear positioning. Together with toca-2, is required for protein trafficking regulating yolk protein clathrin-mediated endocytosis by oocytes during oogenesis and retrograde recycling and the sorting of recycling endosome cargo proteins such as mig-14. Also, together with toca-2, controls the distribution of actin at cell junctions.
Subcellular Localization:
Cell junction. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Basolateral cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm. Cytoplasm, perinuclear region. Recycling endosome. Note=Co-localizes with ajm-1 at cell junctions. Co-localizes with toca-2, rme-1, cdc-42 and wve-1 on recycling endosomes.
Sequence:
MNDSCSWDQLWDQQGTLNEYTGKGIDLLERIMAYSKERASIELEYSSKLKALSKKTAMKMKSESELWNSVSYVKGFHDVIAGIVPVATQHELIAENLKSAVIPFTTQKIAEYRVAKKQLESDNSNLGKQLRMVIDEMAKSHKEYVKCYKETEAAMLKYAKAEKNMDISRLELEKTKNNYQQKCGMLEESKQTYAVMTTKANEEQSAHYDRKLPQLLDNYKKLHTNRILDTVEILSKCVEAESCVNQIIASCHNDMRRDIGLIDPSRDANLVVENMKSGHPVPQPFVFEDLGHPQDRSSFMGGGASGPAGSMDGMDATMKKGGTLMSKNGKGVARKQSMHQKFFGGGTADKKTDSGDYGTLPPQQRARKIAGKISDLEKEKDRATQSREGVSKMQAAYRENPKLGNPSDCDAQLAQYGHEIDALSNQIQKFKILLDDVNAQLGAGGLSATSVGGSDTPPSIRSVSSASSGVTSRVNTINDAHRTNGGVGGGRRESFSGSNGGSDTDPTINGNGHGRDELYEECSNPNPVLGEAIAQFAFDGAQDGTIRMEANEKLWLIEKDEGDGWTRVRKENNSADGFVPSSYLKVTWFGKV
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular Localization:
Cytoplasm.
Sequence:
MEPPPPQSPRDEHPHTHSHSSTSIPTTGTCCKCGGATTHAPPSQSPTSWPDLSSPPAYRPIRAPALNLPPNNTQAIILTPVPQSQEVPTITPPFHFQIPSKKITSPDDIRKFHDSPTSKNFLGFIVALSESIRGRKISDPCHESATVSNIVFIIENLSLWVDQIPPVQQSSRYGNISYRTWHERLTENAKSFMLQFLPEDLKSSTIEIVPYFTDSFGNSSRIDYGTGHETNFAAWLYCLARMGIIKEEDYQAVVARVFVKYLDLMRKLQLVYCLEPAGSHGVWGLDDYHFLPFIFGSSQLIDHKYMKPKSIHNEDILDNFSSEYMYLSCIGFIKKVKKGPFAEHSPLLDDISAVPNWKKVNSGMLKMYKAEVLEKVPIMQHFLFGWLIKWE
The following text describes a protein:
Function:
May be involved in the regulation of cell proliferation; May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MKTVFFLLLATYLALHPGAALQCYSCTAQMNNRDCLNVQNCSLDQHSCFTSRIRAIGLVTVISKGCSSQCEDDSENYYLGKKNITCCYSDLCNVNGAHTLKPPTTLGLLTVLCSLLLWGSSRL
The following text describes a protein:
Function:
Hemoglobin-like protein that exhibits an unusual concentration-independent binding of O(2) and CO. May promote shoot organogenesis from root explants in vitro. Inhibits RGLG3 and RGLG4 ubiquitination activity.
Sequence:
MQSLQDKASVLSGVDQAEAFAIDESNLFDKLGLQTFINLSTNFYTRVYDDEEEWFQSIFSNSNKEDAIQNQYEFFVQRMGGPPLYSQRKGHPALIGRHRPFPVTHQAAERWLEHMQNALDDSVDIDQDSKIKMMKFFRHTAFFLVAGNELKNQNEKPKHKPQCACKHAANKPAEE
The following text describes a protein:
Function:
Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
Subcellular Localization:
Nucleus.
Sequence:
MHRRTRLSLRSSSINDKENEHEQAQLTASPRKRRSKVPDSGVKDAELPEEDGARSPKKVARKAGRPRVLPPAEEDVEELEDAAHGTGASDLVGKLPEREKEYDELVGFVEGVLSSDGSGSLYISGPPGTGKTATLQRILNHPSFAKKLKPVYINCTSIKSVGSIYKKISEELGLKVGGTTEKQYQGAIEAHLERKHKTIMLVLDEIDQLSSSKQTILYSIFEWPARPTTRLILIGIANALDLTDRLLARLQARCELKPQLIQFLPYTKQQIVAILKASLEESNSLSRFPEAALGLLAAKVASTSGDIRRALFIARRLVESAKKEDRKTGSSGAPTVVSMGQVMAVLKQVYGASQTLGNDLEEGFPLQQKILICSLMLMLKHGKNKDITVGKLYDVYKAICTKRNIQAVDQTEFISLCTLVETRGIVRLQGKKEPRMHRVCLQWDEQEVTSALNDKQLIASILSDVSCLGK
The following text describes a protein:
Function:
Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA. Regulation of cell size by ribosome synthesis is an important parameter for stem cell maintenance and function.
Subcellular Localization:
Nucleus, nucleolus. Note=Asymmetric segregation of expression upon mitosis both in germline stem cells (GSCs) and dividing larval neural stem cells (NSCs) (at protein level).
Sequence:
MSSDESSDGLEELQSLKALYGQQEQEKPAKIKRERYIPKASQAKELNYVEVPMEKVLFGDRQRLLTNLAKSVGQKLPNDDEDEQEENPGQAKPGDKRKAAWSDSDDEDLQVGDVKKATKHTGPLNHLRKDKSYKEYLTARFQRTLNQPKWAEKKVKNEDDEDVSSDEELLRTVGFIDRKARNSDLPQKTLNFKRVKDLNRATYAEGNATSIQFHPTSTAALVAGMNGLATIYAVDGQKNERLHNMRFKKFPLACSRIAPCGTRAFFGSVKPFYYSYDLLEAKESKLKLPGAMEFMHRFEVSPCGKFIVTAGKFGAIHLLTAKTNELLHSFKQEGKVKGFTWSSDSKRILVCGSTSNVSVLNLRQNLIEHIFMDDGCIHGESIQLSPNQRLLATGSQEGVVNIYDYESIFASKAPQPEKRFMNLRTAITDLQFNHSSELLAMCSSEAPNAFKLAHFPSATVYSNFPAQNEKVGFVTSMAFSPHSSFLAFATKGKQVPLFRLKYFKGY
The following text describes a protein:
Function:
Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.
Subcellular Localization:
Nucleus.
Sequence:
MADRGKKFNIPNLDDVYDDTSGPVRSLFKAGKTVGASRKGPITANNKHAATTITTTLSSTGDTSKGNVSRTSKSFVTTTSAQQERSVSNGVTNRNQHNISAANLASKITSDGPSTSGQPQASKVAKYDAVPSTSNDSKSFTGIDARDSLGGTMLAGGSSSGPNARSRTGSTFLDVFGLPEGEHCNVGGAAAKAGPAVPRTTKLNSIVINPRQKGNPVIKNIRNVAWEFGDVIPDYVLGKTSCALFLSLRYHHLHPNYIQDRLQQLGRSYMLRILLVQVDVADPHHSLKELAKMCILADCTLILAWSAEEAGKYLETYKAYESKPADLIKEKTDKDYLSKATDFLTTIRSVNKTDVSTLVTTFRSIEGIIKASKEDLALCPGFGPQKAKRVYDALHQPFLRSKKPKPAEQT
The following text describes a protein:
Function:
Specifically methylates guanosine-37 in various tRNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSNPLRFFVLTIFPHIISCYSEYGIVKQAIKKGKVEVYPIDLREFAPKGQVDDVPYGGLPGMVLKPEPIYEAYDYVVENYGKPFVLITEPWGEKLNQKLVNELSKKERIMIICGRYEGVDERVKKIVDMEISLGDFILSGGEIVALAVIDAVSRVLPGVLSEPQSIQEDSFQNRWLGYPVYTRPREYRGMKVPEELLSGHHKLIELWKLWHRIENTVKKRPDLIPKDLTELEKDILNSILSGKSFKEWLKEHKHLL
The following text describes a protein:
Function:
Effector of the programmed cell death (PCD) activators rpr, grim and W. May play an apoptotic role in the germline as well as soma. Role in immune response, required to resist Gram-negative bacterial infections by regulating DptA. Fadd interacts with Dredd, Fadd promotes cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis.
Subcellular Localization:
Cytoplasm.
Sequence:
MSGHNILTQLESIDVLDLPYVERDLNFAQLVSLSFLLYGDEHSTATYILQKLLVLARATASDWPHSDILSQYAKSKPQTWRKYLVEALCIIGARQVLRKLGLCWQELRMHYLPHVGSIRVHIHPLLKSLYTICEELTLAQRGRMVLDIKEKNSVGDPLRFYDAEYLEIFLLDWLTRRLIRLGDFNANGSDVQLLIEYFKFNDLHAQATLLVDTVNAYATSSCSPATPNVLLPMDGNGIANESSSPTAAASRPRAKNALQLSRENAGIALIINQQEFYRDANDDYKVYLPPIELPLRNGTDMDKQRLTNVFSMLGYKVEAHDNLDHLSMLHHIRQACKRSLLHESLVVCILSHGFEDAVYGANSVALRISDIENVLCSYENLYEKPKLVVIQACQQEDKENNALPYKINASTKSPCQYLNMLRAMSTVPGFPALRHTQTGSWFIQSLCDAIVEHSNSDHIADILTIVINNVANKRGNKNETMVPWTGGALRQHVYFPRTSATDKVVPDSPGL
The following text describes a protein:
Function:
Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.
Subcellular Localization:
Cytoplasm.
Sequence:
MDDLREQVELLENSANLSTSIDDIQKAIHQLTAARAKIAADPKTAPLTLAKLQDSFKKSLETAQKDLKPVYAGLNKYGKVLDKVALSPQAPHATAWTDSVLQKFKDKPLPSAENDALSSHPALINRAIAMHLLREGEFDVASTFIDEAKRRPPHPEPTANTPNPYISQSWEKDLAEGTFNSDELQQQFAEMYHILDELRRQRNLEPAIQWAKERSDMLEARGSNLEFELARLEFIRLFNYSDADDMDEYASGPQDAFRYAQQEFAGFQKRYTREIQELMGAMAFFPNLQDSPYRHIFYNDSSWEEVAHSFNREFCSLLGLSADSPLFIAATAGAIALPYLLKMQSIMKEKRTEWTTQNELPVEIPLPSPYHFHSIFVCPVSKEQTTDSNPPMMMPCGHVIADQSLKKLVKNSNTRFKCPYCPSESCLQDARKVVL
The following text describes a protein:
Function:
Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
Domain:
The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.
Sequence:
MKLKNLYIENIRSYRKLDFTFEDGVTVISGVNGSGKSSLLEACFMGLFGSKILSKDFVLADMIFKGAETAKINLGFEHLGKEYLIEQAFRYSSKSENASSSKCVLYADGENIIDQATRTYEEVRTLLNMDEEAYRNCAYIRQGEIDVLINAKPKDRQRMIDDLLQLGKLEEYRERTGYAKTAVRRLERDTKNSLVGVKAEIEGIESTEPVKALNGLKQKAKETDGSLKELNEKKDYAAARKGELDLRIAEYRERLQEIEVLKEAIRKTQEDKAGCFKEKEAFSGEVQGQRRILLELGEENTGLRDDCGFGDLEIEALLLHQEKEESSAREKVNAVSKDLALLLKEGETGSQALCELEKEKTQAERTLLECRTSIGAANKEIEGYRENIRKLEEESKGLREKAGFKAASGAADEIALLIKEFEEKESLLRDRKNEASTKLGLSLKEKETCDLNLVELEKELQNAGAAVRKGSTEIEALEKELRENSKAVLDIQEQKSEVLAELKGLGFAADQLENLEDFSELLLENKSRLHGKEKELEATLRELENNIRKNRELFAAGKCPTCGQELKGSEIACTAEECEDKKEKLASELADIKVQHAELEKKITRLKDAKKLEKRISDYDIEIEKLQEKAKASGKLIETHRARIEEDALKLESLDKRKQELETSGRQLLSDIKTLQVQEAEARKAHIEGEKTLIEVKTLDRKLAENTAEIESLNGKIRTSLALIENYGERLGELNDKLKALAEKENLSKEKLKALELALEAAQKKENEAKKAHSESEKLLGQAKKLQANLLSMENIKHKISELEAAIRNLAEKVGFLDREILERSERIRQLGEKLEGNRLSELQQKRAQFEQAQAKITENIREKTEEKDSLLKEIGMLENSLKRLRELRKELKALENRQLYLEAVYSNAEELENTYIRVRADMRARNIGALSVLLNEMFAFMYTNNAYSHIELDPEYNLTVYRKDGTPLEPKLLSGGERAIFNLVLRCAIYRLLALGFGGDKADGLPPMILDEPTVFLDRGHIRQLLKLIDMMRSIGVGQIIVVSHDDSLIDSADHVFQVEKDPLTNMSSITRL
The following text describes a protein:
Function:
Part of the ABC transporter complex ArtPIQM involved in arginine transport.
Subcellular Localization:
Periplasm.
Sequence:
MKKTLLTAILLGASVAASAQELTFAMQPSYPPFETTNAKGEIIGFDVDVTNAICQEIQATCKFKSETFDALIPNLKAKRFDAAISAIDITDARAKQVLFSDAYYDSSASYVALKGKATLESAKNIGVQNGTTFQQYTVAETKQYSPKSYASLQNAILDLKSGRIDIIFGDTAVLADMISKEPEIQFIGEKVTNKKYFGNGLGIAMHKSNKDLAAQLNKGLAAIKANGEYQKIYDKWITK
The following text describes a protein:
Function:
Key component of the nexin-dynein regulatory complex (N-DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility (By similarity). Involved in sperm motility. Required for the sperm to enter in the coiled storage seminal receptacle (SR) tubule.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme. Note=Detected as regular puncta along the flagellum.
Sequence:
MPKVLFQKYKKVVSNIDPSRYSAKFKEIDEQRRSQGSESDFADEMEGEFEAEMEEMGSSEFSLSEGEPSLNIGKIDLSFPETVEEFENSPQCYPPSYYTLSPKERLLLLYAENFRKQLVLSYPKRRAMVLALPNECKVQKFVCTTIRPTAFIYTQLISSVEEIAKFVADFIQYEPLQDPINLPNRLISPETLLRKRKGNSYEMATLLVSMLIGAGHPALVVSGVAREETILNDQLAVPYPYPIVEVEVEEVKPKVEKPGQKYKLRGLPDLKSHLEEDMAEVHRQKEAEEKRIQDEIIRKQMEDLELLAVDRYHYRRSHAWVVIINNAPWSVKPKTTYTDVNGDVVEAPPTAIFIEPSTGFICETGCKQYILVDSIWNEYNYYVCKQKHQRVSELRWDLRDTKDWEHMLPGEPPEMRIYKMASDENVADEERDISEEKHLDCIGSWVERLHIGLADFEQRFPSSEKKIQYKGAIHERFSPYSQRDGKVMQLTIFNNDECTIPKVRYEYYENRSDLMRHVKYTYATDQFEEIFNKGRNDSLKSIEYFSDPSQQRKVHFFSASRIDSLELMVVEPGSLILHYKDRSDKCWYKEFEFTPAGNVLKKVTEKFLKASANDVCSNDIATRTFLFQQNKIVLKFHYTFGALTATVVEFTKPPRPDYGKELIYDEKLTKIYKANPLDPTRTNLELYRLLCEQLQYEDHLRKNFEKIFEDINNVFDLRKSEKAEPKLKFSIFDPLRNGAARAIRMRQFEEEEELKKEIASKPADFLAPYLVPYKHQEELTPEQSQNAYNACLNDLKSRFVSLLNNLQRHYEDLTSESKSLNRFLNKFENQFNNYDYKRLVQQSKDLELNKRMVQQRLTLTHEESQKKYEVVKNSLLKDPRLNFKKDDLARRASETSK
The following text describes a protein:
Function:
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
Sequence:
MAKKSMIARDVKRAKLVDKYAEKRAELKKRIAAGDMEAMFELNKLPKDSSAVRKRNRCQLDGRPRGYMREFGISRVKFRQLAGAGVIPGVKKSSW
The following text describes a protein:
Function:
Catalyzes the pyridoxal-phosphate-dependent dehydrative deamination of L-threonine and L-serine to ammonia and alpha-ketobutyrate and pyruvate, respectively.
Subcellular Localization:
Cytoplasm.
Sequence:
MMSGRPLHMETPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRGIGHLCKMWAERGCEHFVCSSAGNAGMAAAYAARKLGIPSTIVVPSTTPALTIQRLKNEGATVKVVGETLDEAIRVAKDLEKNNSGWVYVPPFDDPLIWEGHSSIVKELKETMTEKPGAIVLAVGGGGLLCGVVQGLAEVGWRDVPVITMETIGAESFHASTKAGKLVTLPCITSVAKALGVTTVAAQAMKVYREHPIFSEVVSDQEAVAALEKFVDDEKILVEPACGAALAAVYSNVIQKLQGEGKLRTPLSSLVVIVCGGSNISLAQLVALKKQLGMDGLSQ