lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of atg8. The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8 from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8. The formation of the atg8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). The atg8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity). Plays a role in meiosis and sporulation.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The N-terminal region is involved in phosphatidylethanolamine-binding and is required for atg8-PE conjugation; The flexible region (FR) is required for atg7-binding; The handle region (HR) contains the atg8 interaction motif (AIM) and mediates binding to atg8. It is crucial for the cytoplasm-to-vacuole targeting pathway (By similarity).
Sequence:
MAQRLTSAFLNWREHITPASKTSDFENTGMISPEEFVLAGDYLVSKFPTWSWECGDRIRGFLPKDKQYLVTRHVFCVQRNINIGVNEEWVDIETDDTRNKDDDQDDDAISSIHSDTSDIASAERLKGQSKELSDSGPLPLKDEEDDDQMVSPVIKEDEGRYYDLYIVYDKYYRTPRLFLRGWNAGGQLLTMKDIYEDVSGEHAGKTVTMEPFPHYHSHNTMASVHPCKHASVLLKLIKQHRERNDPIRVDQYMVLFLKFVSTMLPYFEIDYTIQA
The following text describes a protein:
Function:
Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MDPGLQQALNRMAPSQDTAMHVPAGSVASHLGTTSRGYFYFTTTALALCLIFAVATIMMLVVQKTDSIPNPPGKFPLKGGNCSEDISCILEKAPFKKSWAYLQVSKHINKSKLSWNKDGIVRGVRYQDGNLVIQFPGWYVIICQLQFLVKCPEHSVDLKLELLINKDVKKQTLVTVCESGAQTKNIYQNLSQFLLEHLQVNSTISVKVDKFQYVDTNTFPLENVLSIFLYSSSD
The following text describes a protein:
Function:
Putative amino acid transporter. Probably transports tryptophan. Involved in maintaining the osmotic homeostasis of the digestive vacuole (By similarity). Important for the timely development and growth of the asexual-stage parasites and male gametocyte maturation (By similarity).
Miscellaneous:
MISCELLANEOUS: Can transport antimalarial drugs such as chloroquine, amodiaquine, mefloquine and quinine.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MNKKYGTSSNNHDNKKDKKNNADKNKNKKNTTTGEENKDSNKSLVNNDSKKNDSSKNKYNIVKANIKNIFASDKKNEKSDKNEKNESSKSSKNTETYTNVNDKKSNNLITKGSNDKKKKKKDSKKNSSNNNNNNTIVDISDGDYTNDEEGTNKPKRNWKGRTFSRFTPGGVRSSTVLFICTAIGVGFLSIPYVFSKLGIILSIILIILNAFESYVTTNILCTSSLEHNTFVYGNLLKKIGNKYYKTIIDFGLSFGFVSSYILILILISNFLSTIFYVFNFPTLFTNNVFLVILICLLILPITFRNKVGSLNHFLIFSLFSLSITVLTIGLQTKSYNNLLINKEVNLFKMDKHFFKCFNILLFSFSQQPNACFITGQFNQPTHRRLNKSTFRSVILQVIFYTLFGILGYFSFLNTAKDNIVLNYENSNVSILLCKFLLSLTFFFSVPLNFMGSYQSMLALGITTRDALYKLYTYIFRRTGYSANLSLLLSEYTNDPYQETHADNITEHSSVSESQTDDQNQRMWISVIVTIFCALIACKVKKLSNVIGIGGGITSTLISCLLPNLIYYKNRHNVSNKLKRYSTLFMLCFFSFMGFLSVVVTTLNLIL
The following text describes a protein:
Function:
Seems to be able to hydrolyze CTP, ATP and UTP.
Miscellaneous:
MISCELLANEOUS: In contrast to uda-1, expression is not induced by stress.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MRWRYTIRDQSPFEESSNCHRLTSSETANTFRWPMRTYNVYGFLLTCTCLLLILTIIPMSGGSSERVQRSVRSVVETKNNIKYGVICDAGSSGTRLFVYTLKPLSGGLTNIDTLIHESEPVVKKVTPGLSSFGDKPEQVVEYLTPLLRFAEEHIPYEQLGETDLLIFATAGMRLLPEAQKDAIIKNLQNGLKSVTALRVSDSNIRIIDGAWEGIYSWIAVNYILGRFDKENDSKVGMIDMGGASVQIAFEIANEKESYNGGNVYEINLGSIETNEDYKYKIYSTTFLGYGANEGLKKYENSLVKSGNSNDSCSPRGLNRLIGEFTVNGTGEWDVCLAQVSSLIGDKAQPSCPNPTCFLRNVIAPSVNLSTVQLYGFSEYWYTTSNFGSGGEYHYQKFTDEVRKYCQKDWNDIQDGFKRNEFPNADIERLGTNCFKAAWVTSVLHDGFNVDKTKHLFQSVLKIAGEEMQWALGAMLYHSKDLKFNLLEQLEVAQSTQQISNFFSFFVILIIVLAVALYRQLQSESTYKKYNFLRTDSKPDFLNV
The following text describes a protein:
Function:
Could act as a receptor for an unknown ligand.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MHESTVGRRAQQRRRFSTRPGTEGSVGTGSVGHLRIFPGVMLHLWILLSLCVPCSLAQGGHEVRMTVKVLSLMFNSAGATVDIINSLNVGFNASLAAQNWTVVPGIDVTVIRPPSYNVSAAEYLENYVKNADDSESLLVVFGPMGEGNIRKSYKVLKEHNLVAFAPLTELTESRKFLPNLYFLRPEPSAELVALIRYAVNHMRVLRLGFMYTESLAGAPSAHSRATELMSQLGYELCCLFTVPNDVEETASGEAFEAEWEKFAQNLPQAAIMFTRINDYTKQIVGRLVSDQRTATTVLLAPSLLQKSLVAVWRQALEASNVSFVPHRLIQTGTNPLAKTTYFGAIRRFQNEARDYLTRHPEWSGLSDSNHFLTNDVDGELMVYGWIAGEVLMRALRSNTKLGDRISFINSLYDQRRYVIDDLVIGDFGGECATGAAAQGAVCDCNRGGKKVFMKEVVKGYHFQHVLPGIFSTSRDHCYSNAIQLHPPLSGVIMRMADNLTMLRAALEFYHGISSTASLLNVGELNRLIMLQVGSTTEQSMNDLVELRKNSIITAVFGVVVEEMLTVKNLTFIDPIVMDPRLNKFRSNVIHLSPTLEQQLYVLVSYLSKNRQGPVHLAVYSREGAEIAEVLTRTLVTFRANLSSSKIFRDVGELEKYLPAKGDVFLLGIGSGNIPIVKEYLRTHQDVRIFVQFSEVMLMYDEFVGVFNGSAGAERVLFATNLPHWGDTDSKSKTVRKFHKVVKPPHRTPLALLGFATERLMQRNIRRMEKVTSQLLVDLFFEEASITVDDMRYGTYDRESCLISGFAAAANCISNFGATNISVWSMARVMNSSVPVLQDPVTPQMFYVDPNANGLTAAQLAGAIAGSVLLFFVLLFIAVPLYFATRSGRDNDNAPKELTAPVTIVFTDIEGSTAQWAAHPEQMPDAVATHHRLIRSLIVQYRCYEVKTIGDSFMIACRSPLAAVQLACNLQRSFLLHNWRTTLFDQSYRQFEEQRAEVENDYVPPTAHLADEAYSQMWNGLRVRVGIHTGLCDIRHDEVTKGYDYYGRTTNMAARTESVTNGGQVLLTRATYLAMSGMEREQFDVTALGALPLRGVPEPVEMYQLNTVAGRQFAALRLDRDVDVLNDGTDGSVLSTSDHSSSRAELSESSQVIVTSLNALLGTFARAQRQKALLPFCERWRVVLPRKPPAIWDDSYYQEVIRRIAVKVGHVVDYCASSGADHTFSTLTSASLIVITQPRGSSS
The following text describes a protein:
Function:
Degrades single-stranded DNA (ssDNA) in a highly processive manner. Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage of DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease or AP lyase.
Domain:
The N-terminal exonuclease domain and the exonuclease C-terminal domain form a central positively charged groove which binds the DNA.
Sequence:
MMNDGKQQSTFLFHDYETFGTHPALDRPAQFAAIRTDSEFNVIGEPEVFYCKPADDYLPQPGAVLITGITPQEARAKGENEAAFAARIHSLFTVPKTCILGYNNVRFDDEVTRNIFYRNFYDPYAWSWQHDNSRWDLLDVMRACYALRPEGINWPENDDGLPSFRLEHLTKANGIEHSNAHDAMADVYATIAMAKLVKTRQPRLFDYLFTHRNKHKLMALIDVPQMKPLVHVSGMFGAWRGNTSWVAPLAWHPENRNAVIMVDLAGDISPLLELDSDTLRERLYTAKTDLGDNAAVPVKLVHINKCPVLAQANTLRPEDADRLGINRQHCLDNLKILRENPQVREKVVAIFAEAEPFTPSDNVDAQLYNGFFSDADRAAMKIVLETEPRNLPALDITFVDKRIEKLLFNYRARNFPGTLDYAEQQRWLEHRRQVFTPEFLQGYADELQMLVQQYADDKEKVALLKALWQYAEEIV
The following text describes a protein:
Function:
May play a role in fatty acid biosynthesis and insulin sensitivity.
Sequence:
MEGHEVAVEPFVLSEIDGRGVVRLTLNRPRQFNALSEEMLEALQRELDAIAANPQARVVVLAGAGKAFCAGHDLKQMQAHPDQAYYEDLFARCTQMMLTIQRLPQPVIARVHGIATAAGCQLVAMCDLAVASTEARFAVSGITVGLFCSTPSVALSRNIGRKAAFEMLVTGEFIDAVTAQRLGLVNRVAAPADLDAEVQRLVDAILAKPAESIAIGKSLFYRQLELPMEEAYRLAGQTMACNMMEPCAQEGVSAFVEKRPPAWANVER
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane during regulated or polarized secretion. Involved in polarized cell growth and organ morphogenesis. During cytokinesis, involved in cell plate initiation, cell plate maturation and formation of new primary cell wall.
Subcellular Localization:
Cytoplasm, cytosol. Cell membrane. Cytoplasm, cytoskeleton, phragmoplast. Secreted, cell wall. Secreted, extracellular exosome. Note=During cytokinesis, localizes to the nascent cell plate and later to the cell plate insertion site and along the post-cytokinetic wall. Shuttles from the cytoplasm to the exocyst-positive organelle (EXPO) in the presence of EXO70E2.
Sequence:
MMVEDLGVEAKEAAVREVAKLLPLPELLQSISSIKADYIARQQANDAQLSTMVAEQVEQAQAGLESLSSSEKTIYELRDNFISIDKLCQECQTLIDNHDQIKLLSNARNNLNKTLKDVEGMMSISVEAAAARDSLSDDKEIVNTYERLTALDGKRRFALAAAGEEVGRLREYFEDVDRTWETFEKTLWGHVSNYYKLSKESPQTLVRALRVVEMQEILDQQLAEEAAEAEGEGAMASVANPRRPGKKSTTTSASSKGLAQQKLKVQGKGYKDKCYEQIRKAVEDRFNRLLTLVFEDLKAALEEARMIGEELGDIYDYVAPCFPPRYEIFQLMVNLYTERFIQMLRLLSDRANDLTNIEILKVTGWVVEYQENLIALGVDDSLAQVCSESGSMDPLMNAYVERMQATTKKWYMNILEADKVQPPKKTEEGKLYTPAAVDLFRILGEQVQIVRDNSTDVMLYRIALAIIQVMIDFQAAEKKRVDEPASDIGLEPLCAMINNNLRCYDLAMELSNSTLEALPQNYAEQVNFEDTCKGFLEVAKEAVHQTVRVIFEDPGVQELLVKLYQKEWCEGQVTEYLVATFGDYFTDVKMYVEERSFRRFVEACLEETVVVYVDHLLTQKNYIKEETIERMRLDEEVLMDFFREYISASKVESRIRIMSDLRELASAESLDAFTLVYSNILEHQPDCPAEVVEKLVSLREGIPRKDTKEVVQECKEIYENTLVDGNPPKTGFVFPRVKCLTASKGSMWRKLT
The following text describes a protein:
Function:
Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
Subcellular Localization:
Nucleus.
Sequence:
CVHGMNPPRDFHDTSTSRRFTPPSTTLSPGKMSETLPLAVQENSASLVGKLRSTDRSMVEVLADHAGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKIDEQTKPGSLSFSERLSELEQLRRTAMRISPHHPAPTANPRASLNHTTAFNPQPQSQIQDTKQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTSLSAELSSRLSTASDLTAFSDPRQFPTLPSISDARMHYPGAFTYTPTPVTSGIGIGMSAMSTATRYHTYLPPPYPGSSQAQGSPFQTSSPSYHLYYGTSAGSYQFSMMSGGDRSPPRILPPCTNASTGSTLLNPNLPNQSDVVEAEGSHSNSPTNMGTTARLEEAVWRPY
The following text describes a protein:
Function:
Binds directly to 16S ribosomal RNA.
Sequence:
MANIKSAIKRAELNVKQNEKNSAQKSAMRTAIKAFEANPSEELFRAASSAIDKAETKGLIHKNKASRDKARLSAKLAK
The following text describes a protein:
Function:
Isoform E is a PKA-dependent transcriptional activator. Isoform J is a direct antagonist of activation by isoform E in cell culture. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Has a role in long-term memory.
Miscellaneous:
MISCELLANEOUS: [Isoform G]: Isolated from Schneider 2 cells.
Subcellular Localization:
Nucleus.
Sequence:
MDNSIVEENGNSSAASGSNDVVDVVAQQAAAAVGGGGGGGGGGGGGNPQQQQQNPQSTTAGGPTGATNNAQGGGVSSVLTTTANCNIQYPIQTLAQHGLQVSIWGPGAWCQLSSVRCYGSQPEVATKDVQSVIQANPSGVIQTAAGTQQQQQALAAATAMQKVVYVAKPPNSTVIHTTPGNAVQVRNKIPPTFPCKIKPEPNTQHPEDSDESLSDDDSQHHRSELTRRPSYNKIFTEISGPDMSGASLPMSDGVLNSQLAGTGAGGNAANSSLMQLDPTYYLSNRMSYNTNNSGIAEDQTRKREIRLQKNREAARECRRKKKEYIKCLENRVAVLENQNKALIEELKSLKELYCQTKND
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide. Essential to photosynthetic carbon dioxide fixation, supplies CO(2) to RuBisCO (ribulose bisphosphate carboxylase, rbcL-rbcS) in the carboxysome (Probable). Loss of activity results in limitation of CO(2) availability to RuBisCO located in the cytoplasm.
Subcellular Localization:
Carboxysome. Note=This cyanobacterium makes beta-type carboxysomes. Associates with the shell portion of carboxysomes (By similarity).
Sequence:
MRKLIEGLRHFRTSYYPSHRDLFEQFAKGQHPRVLFITCSDSRIDPNLITQSGMGELFVIRNAGNLIPPFGAANGGEGASIEYAIAALNIEHVVVCGHSHCGAMKGLLKLNQLQEDMPLVYDWLQHAQATRRLVLDNYSGYETDDLVEILVAENVLTQIENLKTYPIVRSRLFQGKLQIFGWIYEVESGEVLQISRTSSDDTGIDECPVRLPGSQEKAILGRCVVPLTEEVAVAPPEPEPVIAAVAAPPANYSSRGWLAPEQQQRIYRGNAS
The following text describes a protein:
Function:
One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
Sequence:
MFWSSFIGKINQLPVLSQLNNSFLKHVSVRNHKIIKPRNIIKMWKIRKGDEVKVISGKDKGKIGEVLSCDKFRNMVKVKGCNMRKLFVDNKFVYIEKKIHYSNVQLIDNFLKTNTKVALRYTDDNQVIRISKKSGTVIPWPSEKTKEEDYDQIEENPLDTLPQEALKKTYDYKTDVKFMNILRQTVNKYNRELS
The following text describes a protein:
Function:
Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle.
Subcellular Localization:
Membrane; Single-pass type III membrane protein. Secreted.
Sequence:
MQPRRQRLPAPWSGPRGPRPTAPLLALLLLLAPVAAPAGSGDPDDPGQPQDAGVPRRLLQQAARAALHFFNFRSGSPSALRVLAEVQEGRAWINPKEGCKVHVVFSTERYNPESLLQEGEGRLGKCSARVFFKNQKPRPTINVTCTRLIEKKKRQQEDYLLYKQMKQLKNPLEIVSIPDNHGHIDPSLRLIWDLAFLGSSYVMWEMTTQVSHYYLAQLTSVRQWKTNDDTIDFDYTVLLHELSTQEIIPCRIHLVWYPGKPLKVKYHCQELQTPEEASGTEEGSAVVPTELSNF
The following text describes a protein:
Function:
Catalyzes the attachment of the second N-acetyl-N-hydroxylysine to the carboxylic group of N-citryl-N-acetyl-N-hydroxylysine to yield aerobactin. Involved in the biosynthesis of the siderophore aerobactin which is a chelator that mediates the high-affinity iron transport systems induced under iron-stressed conditions.
Sequence:
MNHKDWDLVNRRLVAKMLSELEYEQVFHAESQGDDRYCINLPGAQWRFIAERGIWGWLWIDAQTLRCADEPVLAQTLLMQLKQVLSMSDATVAEHMQDLYATLLGDLQLLKARRGLSASDLINLNADRLQCLLSGHPKFVFNKGRRGWGKEALERYAPEYANTFRLHWLAVKREHMIWRCDNEMDIHQLLTAAMDPQEFARFSQVWQENGLDHNWLPLPVHPWQWQEKIATDFIADFGEGRMVSLGEFGDQWLAQQSLRTLTNASRRGGLDIKLPLTIYNTSCYRGIPGRYIAAGPLASRWLQQVFATDATLVQSGAVILGEPAAGYVSHEGYAALARAPYRYQEMLGVIWRENPCRWLKPDESPFLMATLMEWDENNQPLAGAYIDRSGLDAETWLTQLFRVVVVPLYHLLCRYGVALIAHGQNITLAMKEGVPQRVLLKDFQGDMRLVKEEFPEMDSLPQEVRDVTSRLSADYLIHDLQTGHFVTVLRFISPLMVRLGVPERRFYQLLAAVLSDYMKKHPQMSERFALFSLFRPQIIRVVLNPVKLTWPDLDGGSRMLPNYLEDLQNPLWLVTQEYES
The following text describes a protein:
Function:
Specifically hydrolyzes phosphonoacetate. Does not have activity on other organophosphonates or acetates.
Sequence:
MTQLISVNSRSYRLSSAPTIVICVDGCEQEYINQAIQAGQAPFLAELTGFGTVLTGDCVVPSFTNPNNLSIVTGAPPSVHGICGNFFFDQETQEEVLMNDAKYLRAPTILAEMAKAGQLVAVVTAKDKLRNLLGHQLKGICFSAEKADQVNLEEHGVENILARVGMPVPSVYSADLSEFVFAAGLSLLTNERPDFMYLSTTDYVQHKHAPGTPEANAFYAMMDSYFKRYHEQGAIVAITADHGMNAKTDAIGRPNILFLQDLLDAQYGAQRTRVLLPITDPYVVHHGALGSYATVYLRDAVPQRDAIDFLAGIAGVEAVLTRSQACQRFELPEDRIGDLVVLGERLTVLGSAADKHDLSGLTVPLRSHGGVSEQKVPLIFNRKLVGLDSPGRLRNFDIIDLALNHLA
The following text describes a protein:
Function:
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Does not show fructose-6-P aldolase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRLREITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLGIKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQIIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK
The following text describes a protein:
Function:
Supports abscisic acid (ABA) responses and drought tolerance by regulating the dynamic localization and stability (preventing degradation by the proteasome) of CAR proteins (C2-domain ABA-related, e.g. CAR9).
Subcellular Localization:
Nucleus.
Sequence:
MEASSSQPSDSSDQTASKFLSDLPSRGFLSSTVVSSNPGSLRVYICEHDTSPPEGQLIKTNQQNILIRSLLLKKQKGESSSKDSKGTAEDGPKKRAANRALDDRSSAKRAANASRQEGSSSRTGERDFQSLTVEKLRAMLKEKGLPTKGRKDELIARLKSAN
The following text describes a protein:
Function:
Isoform G2P plays an essential role in viral DNA replication. Binds the origin of replication and cleaves the dsDNA replicative form I (RFI) and becomes covalently bound to it via phosphotyrosine bond, generating the dsDNA replicative form II (RFII). In turn, viral DNA replication initiates at the 3'-OH of the cleavage site. After one round of rolling circle synthesis, protein G2P is linked to the newly synthesized ssDNA and joins the ends of the displaced strand to generate a circular single-stranded molecule ready to be packed into a virion; Isoform G10P protein binds to double-stranded DNA and prevents hydrolysis by nucleases. Additionally, G10P is an inhibitor of DNA replication and may have a role in the transition from semiconservative replicative form DNA replication to single-stranded DNA synthesis in the life cycle.
Sequence:
MIDMLVLRLPFIDSLVCSRLSGNDLIAFVDLSKIATLSGMNLSARTVEYHIDGDLTVSGLSHPFESLPTHYSGIAFKIYEGSKNFYPCVEIKASPAKVLQGHNVFGTTDLALCSEALLLNFANSLPCLYDLLDVNATTISRIDATFSARAPNENIAKQVIDHLRNVSNGQTKSTRSQNWESTVTWNETSRHRTLVAYLKHVELQHQIQQLSSKPSAKMTSYQKEQLKVLSNPDLLEFASGLVRFEARIETRYLKSFGLPLNLFDAIRFASDYNRQGKDLIFDLWSFSFSELFKAFEGDSMNIYDDSAVLDAIQSKHFTITPSGKTSFAKASRYFGFYRRLVNEGYDSVALTMPRNSFWRYVSALVECGIPKSQLMNLSTCNNVVPLVRFINVDFSSQRPDWYNEPVLKIA
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA); A component of Cascade, which participates in CRISPR interference, the third stage of CRISPR immunity. Cascade binds both crRNA and in a sequence-specific manner negatively supercoiled dsDNA target. This leads to the formation of an R-loop in which the crRNA binds the target DNA, displacing the noncomplementary strand. Cas3 is recruited to Cascade, nicks target DNA and then unwinds and cleaves the target, leading to DNA degradation and invader neutralization. CasCDE alone is also able to form R-loops.
Sequence:
MRSYLILRLAGPMQAWGQPTFEGTRPTGRFPTRSGLLGLLGACLGIQRDDTSSLQALSESVQFAVRCDELILDDRRVSVTGLRDYHTVLGAREDYRGLKSHETIQTWREYLCDASFTVALWLTPHATMVISELEKAVLKPRYTPYLGRRSCPLTHPLFLGTCQASDPQKALLNYEPVGGDIYSEESVTGHHLKFTARDEPMITLPRQFASREWYVIKGGMDVSQ
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MFCLLFPSNLPRKKRRMLLCCFIHLLLFPSPAQSDLFTSIGQMTDLLIMEKDLLSSLKDYISAEEQKLRRIKQWAERLDVLSAASSEDAEGFLGHPVNAFKLVKRLNTEWAELENLVLTDMSDAFIANLTIQRQFFPNDEDQAGAAKALMRLQDTYQLETSIISSGQLPGLVLTADDCYDLGKVAYSEADYFHTKLWMTQALRQLEQGEASSTVDTATVLDYLSYSVYQQGELQAALDFTKRLLELDPTHQRANGNLKYFEYQLSKQKKAVQMNESEEDQKGAQADDEYLLERRKYEQLCRGQGALMTPRRLSRLFCRYFNNHGHPNYLIGPVKQEDEWDSPYIVRYHDVASEKEMETVKELAKPRLRRATVHDPQTGKLTTAQYRVSKSAWLGSHEHPIVDRINQRIEDITGLDVSTAEDLQVANYGVGGQYEPHFDFGRKDEADAFEELGTGNRIATWLLYMSDVQAGGNTVFTDIGAVVWPKKGTAVFWYNLHRSGEGDYRTRHAACPVLVGNKWGESTFLHKGKQKRRPSGGSYRMKKLVRNLGRS
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MGKCCCLVLVTIVAVLVLGLAIGIPVGMKKAKEKVKNWDPTAVNSACQSTRYPDTCNETFTGDYPRDTNGVMRHSVQSSEKGVNDTLGFMSEFDSSDPVISGAVEVCNEVLVSAREELEAASTALETKDTLGVDTLKDIQAWVSAAMELHTTCIDAFMEVNNVTGSALAKKSAKTDELLSNSLAFINALAQYGNDLLAWRPTGISLPEGFNFTLPNVTLPNIPGFGNRKLLSVEELEMDEGFPGWMDVETRRHLLQAPPKYDVVVAQDGSGNFRTIQAAVDAHKTNTKRLVIYIKAGIYNEQVIVPKKAKFLTLIGDGDRTVLTGDRNVALMKGMTTFKSATLIVSGAGFVGRSFRVQNTAGAEGHQAVAFRGSADNIAFYQVTFDSFQDTLYCHSFRQFYRDCTVFGTVDFIFGNAAAAFQNCKIIAKKSTILGQQNTYTAQGRTDPNQATGLSFQNCVIDGTSDLMASVAQYKSYLGRPWKAYSVCVIMKSEIKGHVDPTGWLPWNTTNFGLYTSYFAEYKNFGLGSAIDNRVQWSHQVGNDKQANYYQANNFIQASEWVSGLDVPLTTAL
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSVPAFIDLSEADQISELQQYFKSKNIEVKEEGVLFNDVKQLIISTAELWKDTEGKDIEGVVNSILSLLFVIPIDKGCELVDLLCEQLLRGAESGKAPVSLNLLHNLFHGYPTKTPFLCKVYSTWLKLAKVSRSIHLVPTNLKELSSWLEDWNAGEEGRQNVLRLLYEAQLNCGRNKEAAETMITLLQSYTEENAGKAREDAIRCITKALADPNTYLFNQLLTLKPVTFLEGEPLHDLLNIFVSGNIKEYKDFYETNKEFIESIGLSHTSNTRKMQLLTLVDNFGSAREISFDDIIARLDISEDDVEEFIIDAIQSKLMRGRIDHVNRKVIVSQACQRIFGRAQWESLASRLEQWRDNINRVNGKLQTLQV
The following text describes a protein:
Function:
Acid lipase that can hydrolyze a range of triacylglycerols without a clear preference for acyl-chains. Can also cleave 1,2-diacylglycerol, 1,3-diacylglycerol and 1-monoacylglycerol, but not phosphatidylcholine, phosphatidylethanolamine, or sterol esters. Required for pollen tube growth. Triacylglycerol hydrolysis by OBL1 may provide acyl groups for the synthesis of membrane lipids in growing pollen tubes (Probable).
Subcellular Localization:
Lipid droplet. Membrane; Single-pass membrane protein. Note=Associates with the oil body membrane.
Sequence:
MHKDNDSGSGSNPGQVSNYLIVRPHRGGYIDLFRYGVRDDQTSKAKFLEMPDNREWSTITIDEEAEDHRWVIVVSILVRKIIRLLRTPMEFTGFVVDFFLNLFSANGGFFGLLLRLIQAKVVIPERGSVTFVSTIGQLDGRISLYKEWNFVEHLEGIDSVDSGRVKIELGSRGLMDLCVMASKLAYENAKVVENVVDLHWKMNLVEFLDCWNDYQKQMSTQVFVFTDKQKDANLIVISFRGTEPFDADDWGTDFDYSWYEVPNVGKLHMGFLEAMGLGNRDDTTTFHYNLFEQTSSEEENSKKNLLDMVERSAYYAVRVILKRLLSEHENARFVVTGHSLGGALAILFPTLLVLNEETEIMKRLLGVYTFGQPRIGNREVGLFMKAQLNQPVDRYFRVVYCNDIVPRLPYDDKTFLYKHFGLCLFYDSFYNETKAEDEPDPNPYGLRYKILGHVIAVWELVRGLTMGYTHGPDYKEGWFRILFRLMGLVIPGLSDHCMTDYVNSVRLGPDNELQMSSL
The following text describes a protein:
Function:
ARL8 effector that promotes the coupling of endolysosomes to dynein-dynactin for retrograde transport along microtubules. Acts by binding both GTP-bound ARL8 and dynein-dynactin. In nonneuronal cells, promotes concentration of endolysosomes in the juxtanuclear area. In hippocampal neurons, drives retrograde transport of endolysosomes from the axon to the soma. Positive regulator of macroautophagy in dendritic cells. Increases autophagic flux, probably by stimulating both autophagosome formation and facilitating tethering with lysosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger. Positive regulator of osteosclast bone-resorbing activity, possibly by promoting late endosome-lysosome fusion by acting as an adapter protein between RAB7A on late endosomes and LAMP2 on primary lysosomes.
Subcellular Localization:
Cytoplasmic vesicle, autophagosome. Lysosome.
Sequence:
MAEKETILKISRNLKNAVSAILQGYGDGQGPVTDTSAELHRLCGCLELLLQFDQKEQRSFLGARKDYWDFLFTALRRQRGYTEQMNFICSQDKLKTSLGKGRAFIRLCLAHGQLAESMQLCLLNPQLTREWYGPRSPLLCPELQGDILDSLYTLNGVAFNLDLQRPDLDEAWPMFSESHYSSPSRTRERRPRKPKGFPEEVRCSKGQQLQGPEAGGTSCLQDATTEDLPPDLRTPLQQDHLPTFLEEKREDSRSLSCPQSIWETGREGFRLDQEGGPKTRKLLENSTASIQQQKGGAKDVQMQLTGRKDEGKGSLPGTEGRKTTEGIQERATDWNHAQELLAPSLQGREEDAELGYRHGWDQPGALGQSWVLGSKKGPTTGKPQEWTGVTRATVQKDQTEVPLQQEVIKEPGYGLQLTEVQAQCQEQLQAQEGELQALQEQLSRCQEERALLQAMLEQKQQEAERRAAMYEKELEGQRDLVQAMKRRVLELIQEKDHQWQRLQQLSTVTPGHCMGCNKVFRRLSRRYPCRLQEERALLPSLCPAGRNPGHLTKIAQGT
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MASSSILIPPILTRRNLLLSTTIATVTPPPPAKPPSPDITITDRVFLDFSLCPTYFRSDPSATLSSTTPCSDSTPLGRVVLGLYGRHVPITVSTFKRMCTSSSTSYKNTPVHKIFPGQYFLAGRQGGGRRDTAEVGYSLRDLPRNTDVVNSKAFLLPHARAGVVSLCLSENDDDDDIRLDPDYRNVEFLITTGPGPSPQLDGGNIVFGTVLEGLDVVTSISSIPTYKPSENIKQFNDFAEFLGDERAQNARSLWNRPLKTVFISGCGELKVTNPSLSPTLP
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAHEVHRIKPKLGRTQIFWVFLAFRVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWKFGVRSYLFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVTRSFEYYGVIYAPKIVMAVLASIGEYYIVRFVQKLYLLTLDKRNEKEEEERRSGLSEITKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLIFAFLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMYFYEKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDRDYWKRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIEVMKFLHEEPEIDSLGFIMPCHSTPGQSYLHRSDIQDLWSITCNPPLHLLGDPEAYSKLETYMDESDHLYDDISAFIYKNFPPPFRKDLRSPGKTYSHEWPTYLVVFEHMENAFLKDFLKDSSYIEYNRFFNSLAHWDSRRSGDIIIYYKLPFDYSDIPAADI
The following text describes a protein:
Function:
Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
Sequence:
MDSIRDKCGVFAVSSPKEVNIQLVVEGIRLLQHRGQESAGIAYAENGEILTIKGSGLVDEVFKENLNKFIKNGIGHVRYSTSGKSSIEEAQPLGDSKIVVAFNGTISNYYQFGSFRVDTEFIYKFFKQKLAFRSIPDTVKEFMKVVDGGYSVAILLNDEEIVVFRDPKGFHPVVLGFLEGSLIVSSEDSVIRQLGGSVLKHILPSEMIIMKNGKILYDKVIYEEKNYATCSFEYIYFARPDSNIDGHSVYLARIRLGELLAEKHPANGDIVVPVPDSSRPIALGFSRKSHIPLEEPLVRTISSVRSFIMPTQDKRNEVLEEKFGVVADAVRGKRIVLIDDSIVRGNTMKRIITMLRKAGAKEIHVRIGSPMIKYPCYMGIDFPKREELIAHNKSEKEIGNELNADSIEFLSVEEMLQGIGRRDLCNACFSGIYPLKFNYNSTELERIFGK