lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
A cholesterol-dependent pore-forming toxin, which is a major virulence factor required for the escape of bacteria from phagosomal vacuoles and entry into the host cytosol. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Listeriolysin O activates mitogen-activated protein (MAP) kinase activity in host cells, most likely as a result of the permeabilization of the host cell membrane. Also induces a proteasome-independent degradation of UBE2I (the SUMO-conjugating enzyme UBC9) and a proteasome-dependent degradation of some sumoylated proteins. Finally, is necessary and sufficient for spacious Listeria-containing phagosomes (SLAPs) formation, suggesting a role for listeriolysin O in promoting L.monocytogenes replication in vacuoles, leading to persistent infection. Recognized by serum from healthy humans exposed to L.monocytogenes as well from patients who have recovered from listeriosis.
Subcellular Localization:
Secreted. Host membrane; Multi-pass membrane protein. Host cell membrane; Multi-pass membrane protein. Note=Secreted as soluble protein that then inserts into the host membrane and forms pores formed by transmembrane beta-strands.
Domain:
The N-terminal region is not required for secretion and hemolytic activity, but is involved in phagosomal escape of bacteria in infected cells and is critical for bacterial virulence. This region contains a PEST-like sequence, which does not mediate proteasomal degradation, but controls listeriolysin O production in the cytosol.
Sequence:
MKKIMLVFITLILVSLPIAQQTEAKDASAFNKENSISSMAPPASPPASPKTPIEKKHADEIDKYIQGLDYNKNNVLVYHGDAVTNVPPRKGYKDGNEYIVVEKKKKSINQNNADIQVVNAISSLTYPGALVKANSELVENQPDVLPVKRDSLTLSIDLPGMTNQDNKIVVKNATKSNVNNAVNTLVERWNEKYAQAYPNVSAKIDYDDEMAYSESQLIAKFGTAFKAVNNSLNVNFGAISEGKMQEEVISFKQIYYNVNVNEPTRPSRFFGKAVTKEQLQALGVNAENPPAYISSVAYGRQVYLKLSTNSHSTKVKAAFDAAVSGKSVSGDVELTNIIKNSSFKAVIYGGSAKDEVQIIDGNLGDLRDILKKGATFNRETPGVPIAYTTNFLKDNELAVIKNNSEYIETTSKAYTDGKINIDHSGGYVAQFNISWDEVNYDPEGNEIVQHKNWSENNKSKLAHFTSSIYLPGNARNINVYAKECTGLAWEWWRTVIDDRNLPLVKNRNISIWGTTLYPKYSNKVDNPIE
The following text describes a protein:
Function:
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
Subcellular Localization:
Nucleus.
Sequence:
MEVGRLPISASQRGKLISAGYTTLASLSSLSSSDLARDLKIPESEAFEILKVASHDCRLDQPDKSNGIFTGAQTAWEMLHEEQLFPRITTSCADLDNILGGGINCKEVTEIGGVPGIGKTQLGIQLAVNVQIPVDFGGLGGKAVYIDTEGSFMVERALQIAEASVVDMSHYNELLWKELRTCQVEIQPTDILKNIFYFRICSYTEQIALINHLDKFILEHKDVKIVIIDSVTFHFRQDFEDLALRTRLLGGMALKLMNLANKYNLAVSNMIASYSLWQVVIFNQVTTKHKEGSFQLSLALGDSWSHCCTNRVILYWNGDERNAHIDKSPSLKSASAPFSVTRKGIRNSASNHKRIKLM
The following text describes a protein:
Function:
Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum.
Sequence:
MPRFLLVCLVLADALAVPTTATEEVEARFMLKGHSHSEPDPPALGPEVGTAQTPSTQWVNGGDSAVELTSSDQPAPSEAANRAIRFGAELRITITPTLSPFLILPTLPLYLSECKPLSPLVFLLPPRPDGSGVRPSTDEVGIEGWNETNDSYGFTYVKDSKGSKKSVLVKCLVTGDDLIVDALDIGLGERKPMNHQININDYDGGSGGTNYSRMYKNFTELVRSLNSSILAKLESLSTMPSGSTPSLPRSKESVESECDKGDPRVRVLEPQVPQQLPPVLVYPQVPSLGSSDLYPGPAIGVYPSWSTGIGGGMLLGPNDPSWFSGTYGEQIGVPGGVPGVPPGARFDPYGPPGVSGFEPNRFVRVPRRSGGGAHPDLEHFRDDSDMI
The following text describes a protein:
Function:
Could be required for the biogenesis of a putative fimbria.
Subcellular Localization:
Periplasm.
Sequence:
MRYLNTKNIIAAGVLLSCMSSIAWGAIIPDRTRIIMNESDKGEALKLTNQSKNLPYLAQTWIEDTKGNKSRDFIVTVPPMVRLNPSEQIQIRMITQEKIAQLPKDRETLFYFNVREIPPKTDKKNVMQVTMQHALKLFWRPKAIELEDDGVMTYEKVEIIRRNDGSIRFNNKMPYHVTLGYIGTNGVTMLPQTQSLMVTPFSYANTQFKNVPSTFQVGYINDFGGLSFYEINCPVVNNICNISVANRDQ
The following text describes a protein:
Function:
Photoreceptor for short wavelength (UV) light that mediates UV-light-induced avoidance behavior. Directly senses and absorbs both UV-A and UV-B light with very high efficiency. Absorption of UV-B but not UV-A light shows resistance to photobleaching. In contrast to other photoreceptors, does not use a prosthetic chromophore to capture photons and only depends on its protein conformation. Might have a role in response to white light exposure.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
In contrast to other members of the family, adopts a reversed membrane topology.
Sequence:
MPPPSSHSNIFHSTFKHTVKETMANAKKTMIAKILSSRNKWAICDRTLYPIYYLLLILGLNQSIRPNNSLLFRIYSWLVFCLLLFTTLRKFNQVGVRPNGTRENLQEFFANPRSMITLCNALIMLSGLLASLQLYTLGAKRLKPLKILCQFSLNVRTKQAERRQFMINTFLAVFSGLLALTMAATYAMSKWGYILYIVGTPNLDTETIFCVLLDSYALFVSRAAISALAILFYQHCSVIRRSIKHLINEMVPAEQDECPLPESSLQKIHDCQISYQRIFNGKAVIEEYYSFVLFYSYGVCIPIFCFLMFVGMSAQSICWSEVVSIVIWIVNAILVLLLFSLPAFMINEDGDRLVASSFRMYHETFHEERDLTVLSQMTFFTFQIHSTKLTLSACNYFYMDRSILLSLFSAILTYFLILWEFDIKNNQSLQNIANHTIHT
The following text describes a protein:
Function:
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MLAKRIIPCLDVKDGRVVKGVNFLNLRDAGDPVENALYYNEEEADELVFLDVTASHEKRKIIIDVVERTASVVFMPLTVGGGIKSLDDIRDLLNAGADKVSINTTAVKDPYFIQKASTRFGSQCIVIAIDAKRVDKNFNPKAYPPESWFDDKELSDVLYKEDSRFVLSTHGGRLMRPIDAIAWAKKMEEFGAGEILLTSMDRDGTKEGYDIELTRAISEAVSIPVIASGGAGTLEHLYEAFAYAKADAALAASIFHFREYSIREAKEFLRQKGIPVRI
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MIGPGSIALIVGAALVIFGPKKLPELGRAAGDTLREFKNATKGMMDDSKEETKKEDLRP
The following text describes a protein:
Function:
Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction with CETN2.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localized close to the centriole. Localizes to the distal end of centrioles.
Domain:
CETN2-binding regions contains a conserved Trp residue in their C-terminal ends, which seems critical for interaction with CETN2.
Sequence:
MKNLLTEKCISSHNFHQKVIKQRMEKKVDSRYFKDGAVKKPYSAKTLSNKKSSASFGIRRELPSTSHLVQYRGTHTCTRQGRLRELRIRCVARKFLYLWIRMTFGRVFPSKARFYYEQRLLRKVFEEWKEEWWVFQHEWKLCVRADCHYRYYLYNLMFQTWKTYVRQQQEMRNKYIRAEVHDAKQKMRQAWKSWLIYVVVRRTKLQMQTTALEFRQRIILRVWWSTWRQRLGQVRVSRALHASALKHRALSLQVQAWSQWREQLLYVQKEKQKVVSAVKHHQHWQKRRFLKAWLEYLQVRRVKRQQNEMAERFHHVTVLQIYFCDWQQAWERRESLYAHHAQVEKLARKMALRRAFTHWKHYMLLCAEEAAQFEMAEEHHRHSQLYFCFRALKDNVTHAHLQQIRRNLAHQQHGVTLLHRFWNLWRSQIEQKKERELLPLLHAAWDHYRIALLCKCIELWLQYTQKRRYKQLLQARADGHFQQRALPAAFHTWNRLWRWRHQENVLSARATRFHRETLEKQVFSLWRQKMFQHRENRLAERMAILHAERQLLYRSWFMWHQQAAARHQEQEWQTVACAHHRHGRLKKAFCLWRESAQGLRTERTGRVRAAEFHMAQLLRWAWSQWRECLALRGAERQKLMRADLHHQHSVLHRALQAWVTYQGRVRSILREVAARESQHNRQLLRGALRRWKENTMARVDEAKKTFQASTHYRRTICSKVLVQWREAVSVQMYYRQQEDCAIWEAQKVLDRGCLRTWFQRWWDCSRRSAQQRLQLERAVQHHHRQLLLEGLARWKTHHLQCVRKRLLHRQSTQLLAQRLSRTCFRQWRQQLAARRQEQRATVRALWFWAFSLQAKVWATWLAFVLERRRKKARLQWALQAYQGQLLQEGATRLLRFAASMKASRQQLQAQQQVQAAHSLHRAVRRCATLWKQKVLGRGGKPQPLAAIAPSRKVTFEGPLLNRIAAGAGDGTLETKRPQASRPLGALGRLAAEEPHALELNTAHSARKQPRRPHFLLEPAQSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTASTGPELLLLPLSSFMPCGAAAPARVSAQRATPRDKPPVPSSLASVPDPHLLLPGDFSATRAGPGLSTAGSLDLEAELEEIQQQLLHYQTTKQNLWSCRRQASSLRRWLELNREEPGPEDQEVEQQVQKELEQVEMQIQLLAEELQAQRQPIGACVARIQALRQALC
The following text describes a protein:
Function:
Beta-1,2-xylosyltransferase that plays a key role in capsule polysaccharide synthesis by transferring xylose to alpha-1,3-dimannoside in a beta-1,2-linkage. Also mediates glycosylation of glycosphingolipids; constitutes the unique xylosyltransferase responsible for adding xylose to glycosphingolipids.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MPLNLPFSSPLKLPLPRRFIILILSASILILFLHTFAPSTLPPVLTPNLPHHEPDASYFSPSKWLPPILNPNAPTRPLEFDEDGQCLFLSPFDALSAAEKARARVLSLDEISPGIVRADAPPAEGTDADPDFDDEFSELSNATRKMPAGLTHPILGLLRDGEAKWNSMVTMQSQTLEQAVDVYMDRWGRRPPKGFDEWWHFAKANNVLLPDEYDPIMNSLLPFYALPIDTLKERLVEAEKIPETFTLIVHDGKVELKWNDDYSRDTWWASRPRADSQINLMEPFIKHIGTFRATFTIHDQPSILLDHERQEELLTAARHGKISTHPNELDRAEQNWRKACPPDSPLNKGEEELEAPDSFISSHLAAMDICQHPSYMENHGMLLEEKNSDSHPKPHTKLYPILVPSKTALNGDIPVTPIGKDGRRDDIGHDPEWNRKSGKLYWRGLATGLQHNKKAGAKWRQSHRERLHFLANDKSDTYTEVLSPVGSSGEAELARMPLRELGQYYMDVKLAGGNWQCDWGDGTCEEMEKEIDFAPKDSSERSNDFKYVFDTDGNAWSSRFPRLMASNNVVIKSTVFPEWNTNSLPEWYAYVPSKMDYSDLFSIMTFFRGTPSGRGAHDEVARRIALNGQCWVERTWRREDLQAYMFRLYLEYARLTSPDRDNGKMDYVSTQKKASKEADDVPAAADIETPVIDQ
The following text describes a protein:
Function:
Probably acts as a transcriptional regulator. Required for the specification of the tarsal segment. Also involved in antenna development.
Subcellular Localization:
Nucleus.
Sequence:
MGSQQFCLKWNNHQSNMLVVFEQLLSNEALVDVTLACEGHSLKAHRMVLSACSPFFQALFVENPCQHPIVILKDMRYMDLKAIVEFMYKGEVNVSQDQLSALLKTAEALKVKGLAEVTGDNRHGVVSVDGADSRTISTARAESPTMSKRKRGRPRRRSRSDSKSDSDDQGAPPAIRIKTPESPEIIEDGSLSSDRVTAVAAESPAARTLSSVAATLTAASSCAVAAPSNKVAAGLSATAANNSMSSQHTMDSVGDDTGADDADFEVEPSNLLEQSMTTENVPVFAAVASSSSSQAAESQQSHPKASASDIPALVHVPASLPSDISISSQLDIKPSPSSLIPPFEEQALSPAVPPQPSGSGSGDGSSGAMMMAFTDMSGVPAIAGPSSYHPDNQQSTPSHGRYSHPSPSPSAPTTPERAARFLPSTLHCLLCKVGCGDRSVQAAFFHCC
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSHPCVSFLAPPAPQGLALPQDGAPGNQVLAVPLEMLEAQDLVSFDIVPWHLTEQEWLGLSLNPEQQALAYSRAVTSIGVPVVSPALVSHLSQGQVLLVSDPTLNTDHTKHPESTSATSHQKMGEEAQLQEMASTSSPRANDPSAEVKQNGDSGGRGGSPQNLPIEHHFACKECGDTFRLKVLLVQHQRVHSEEKGWECGDCRKVFRGVSEFNEHRNSHAAVAAQPRPGPSRALEDALEKREQMEREAKPFECEECGKRFKKNAGLSQHLRVHSREKPFDCEECGQSFKANTHLFRHQKLHTSEKPFACKACSRDFLDRQELLKHQRMHTGHLPFDCDDCGKSFRGVNGLAEHQRIHSGAKPYGCPHCGKLFRRSSELTKHRRIHTGEKPYECNQCGKAFRQSSSLLEHTRIHSGERPYACGDCGKAFRGPSDLIKHRRIHSGLKPYECDKCGKAFRRSSGLSRHRRIHSGVKRCECSECGRVFKRRSALQKHQPSHRE
The following text describes a protein:
Function:
Transcriptional coactivator which is the critical downstream regulatory target in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Regulates the expression of G1/S-specific CycE and diap1, thereby promoting cell proliferation and inhibiting apoptosis. Required for transcriptional activity of sd in wing imaginal disks. Induces expression of expression of vestigial (vg) in wing and haltere disks and the expression of transcription factor E2f (E2f).
Miscellaneous:
MISCELLANEOUS: Named for its loss-of-function phenotype after a very small breed of dog, the Yorkshire Terrier.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. sd promotes its nuclear localization. 14-3-3epsilon, 14-3-3zeta and wts inhibit its nuclear localization.
Sequence:
MLTTMSASSNTNSLIEKEIDDEDMLSPIKSNNLVVRVNQDTDDNLQALFDSVLNPGDAKRPLQLPLRMRKLPNSFFTPPAPSHSRANSADSTYDAGSQSSINIGNKASIVQQPDGQSPIAAIPQLQIQPSPQHSRLAIHHSRARSSPASLQQNYNVRARSDAAAANNPNANPSSQQQPAGPTFPENSAQEFPSGAPASSAIDLDAMNTCMSQDIPMSMQTVHKKQRSYDVISPIQLNRQLGALPPGWEQAKTNDGQIYYLNHTTKSTQWEDPRIQYRQQQQILMAERIKQNDVLQTTKQTTTSTIANNLGPLPDGWEQAVTESGDLYFINHIDRTTSWNDPRMQSGLSVLDCPDNLVSSLQIEDNLCSNLFNDAQAIVNPPSSHKPDDLEWYKIN
The following text describes a protein:
Function:
This promotes the activity of RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MSTPIRLPDSLPYPITIAQLGVSTGDTVEKGQRLLAYKYWDLVDVITAPGEEEAGKARKQRVDLVGTFDSPVAGTVVSLDVRVGDEFVNSQRPVVEIRQACPHDVTYGGLCVQCGQAVEDEAGAADGVEQAKLTVSHTNTHIRVSERQAASLGQSAQLKLREARKLVLVVDLDQTVIHCGVDPTIGEWSKDPNNPNYEALKDVQSFSLDEEPVLPPFYMGPKPPTRKCWYYVKLRPGLKEFFAKIAPHFELHIYTMATRAYALEIAKIIDPDGKLFGDRILSRDENGSLTQKSLERLFPMDQSMVVVIDDRGDVWNWCENLIKVVPYDFFVGIGDINSNFLPIQQNSMLHLGRRNRKKPKQEEELLTDILDTEKKLKEKINEEVKRQEDQMHRLTDEKLPDTRDIAKKLEHNASLEVQQQNRPLAELQKHMRNERLLFDDDDELPHLGNILLKVHSAYYDQLQRYNSGEDPIPDIKILMPKLKETVFEGCRFVFSGLIPLHTNIERADIVLWTNMFGASTTANLDYNTTHLITRTPGTMKARLAKSFNPAIKIVHPDWIFECLVGWERVEESPYELIVEEPVGEEYLENFKRDLAEAQKKVDPPAQDSRSSLLLLDGNGSWLDYDDDEMDEFLNEESDNEEDTEQMATASKAPRPNGFPSGGERPAAVQSQDKPELPEKESNGKRPYQPDDAVSASKVKLQRTDAFSEEAEEEDEDDLEAELLLELGQ
The following text describes a protein:
Function:
Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.
Sequence:
MEMSVLKDLSIPAADECVYTACYCEENVWKLCELTRATRPELLAQCSVVFVSNRRRAVPIWCQKSGSDSTGLSVWDYHVFFVYRPADGRPCQVYDLDTTLDFPVDFAVYVEHSFHPQTNLSPELAPMFRVVDASQFLDTFASDRSRMRAPDGSWLKPPPRYPCISTPSATDNLDEFVSVDEGVGVGNVYTLRQFVRKLDE
The following text describes a protein:
Function:
Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid.
Sequence:
MKKQEISILNIPFYNTTQAGFVEELYMAAKNGERRFVVTANPEIVMHARTDKEFEAILGQADYIVPDGIGIIMASEKLGEPLKERVTGYDTMVGLLNKPLNCYFLGAKPEISEVVEAKVREKFPQAVVCGVHHGYFDVLESEGIAKEILVSQPDVIFVALGSPAQEKWILSQIANFTKGIFIGVGGSFDVLTDSVKRAPKIWIKLRLEWVYRLLSNPSRWKRFFAIPQFMLAIRKERKRLKKGE
The following text describes a protein:
Function:
Has a role in the initiation of DNA replication. Required at S-phase checkpoint. Also required for the proper activation of RAD53 in response to DNA damage and replication blocks.
Miscellaneous:
MISCELLANEOUS: Present with 656 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MYSFELDKLKIELKTWEHDFIDKNKREPTRDDIKSLRTVRQMYKQYSTLKKKQSLQRQKVDTQESVELPAHKKDHDEVVEIGPTPQVYGKAISIFDMNLSPIKPIYMTFTNNIDVNNDNSKTISNESSPRKTILLKSSPADRTLVAEPISSVKRQLNFQMLNASSTRTPTSSPCKNRNGKLVEIKKCSPTINPPLESGKPSGYYGPNSPLKLDEENIHLNISLNSSTKRRLQIAYPSLQKTPSKDQADISTSFSPSPLIRRPLTKSLIELAREHTEIVKEFGVLQEEDIEEEEEGEEGENGYDEKNHEDDFGLEDELIRPKVVKDIFQEDDDNDDSQAREDTFIRKRPKRRKVIRRLRDNDPETETAGFERDVHKELVKLKRRKVAEFLGSTSQISDTEFEHDPEASSGVVSSEQKPTAKRKGRKKYNLVSNNFRRLKLPKKNRFSNGRWGRR
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MADSFTQPLSLPKPHSGPTSVTNVAVQPLPLAAILDHHLRRPDHQDRVFGTLLGVRNTETGEVEVRSSFGVPYAATGRDVAVDSDHHRTLLELHHRVSPKEVVVGWYATSPILNSFSSLIQDFYNLEAIPLPAVHLTLDPVTLTFKTFVSSPIGLSTLQTLNLLFKPIPCSLSIPTPERTTMELLTKPILDSTAANQNIESDLKNQQQKIMAQLKEPLKTDLPMQHLHQLLTKLKNMLDQVYEYVEKVNKGQIKGNNQVGRLLLDTMGSLPLGLLRSQTGSASKGGDVHSQFEDDFQSHIADVLMVSYVAALVRDQVEISSRLNLLVS
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Mitochondrion.
Sequence:
MPFMNFRNFNFMPLLRPLNPVYKGAEHLCRKNIHNQVYNVETGKTIQILQDLVPLVLYRALPDAILDHHVELVIFPNSLNFPRIEGLTIYKFIFKTARLLLSSTYGSSAKRPIDIIHQLHSSMENKNVRYSMKCNWIASPNDEYTWVFHFDIDKKGIIYRHIIDNLERNRSRQCEKISALKPDPIE
The following text describes a protein:
Function:
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 1200 molecules/cell in log phase SD medium; MISCELLANEOUS: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.
Subcellular Localization:
Mitochondrion.
Sequence:
MSRCIRQSVCTNFNVCRRQCFSTYASALKEMTHPIKPSAQTLRHLQFTQRIPFQKGLEIQETLVRANLDIKDIQSKIERKLIQLDEEYKGTATINDNEKRILDKVMAMKPNPIILTFEFEPTYTGGKRIKKTMTPDQIAAYESFIPETQKDNPRPKFVQVERGGQVTFHGPGQIVIYIILDLKTFQSFPAKCLVSCIEQATIRTLKNTKMCDDTDKPLNLDAMTTKDTGVWVENGKKKVASVGIHVRRSITSHGVAINVNTDLSYMNSFEMCGLKNTLTTSIMEQRPDAVVNVQSVAISFVKEMTKLLGIKTLERMQIDDVNILKKNP
The following text describes a protein:
Function:
May be involved in podosome and invadosome formation.
Subcellular Localization:
Cell projection, invadopodium. Cell projection, podosome. Cytoplasm, cytoskeleton, stress fiber.
Sequence:
MDTSSTMSMDALVSELSVLLKMLDQENLSSSIQEKKTSVWNLLQQIQPPVSGTDYIYMNSSVYRNGTSFVESLFDTFDCAIGDLKDVGEDLREDAAMNTDIVKPQVSADSPASHSAIFPPPLPTTPPPEEYYEEAVPLSPGKMPEYIITRGRPSPPNSIEEAYEDADNHYPITCINSQRKNSYNDSDALSSSYESYEDDEEERSPDIRLTHQWPSVESSMPPARDCRICAFLLRKKRFGQWGKQLTVIRENRLQCYKSSKDTSPNVDLLLSQCTVVYVPKDSKRKHHELRFTLPNGDGIVLAVQSKEQAQTWLTVVREVTGQSTGSEESASPVIPRKNELDKRLSAERSTSDSDSVVVSAGDKENGKVKRSAFAAGRKISQIISFSKKKYSRANNKDPGQGYLSVLINQVWRERWCCVCKGSLHFYHDKGDPHTSLPSLSLHGCEVIPGLGPKHPFAFRILKNSTEVAALEASSSEELGRWLGVLLAEMGSSTDPESLHYDYVDVETIANIRDAARCSFLWATSSSSSSKDFRTYDEVPNEDVQLRETRKQQSGNQAKRRSNFSSSDSDRTKPLTSIKRINSHANQYGKYGKTRAEEDAKRYLRDKEELESEKNGIRNALVILRQEKRELKEELKTASDSRKLFLETRVSELEEACRAKEAERVDLELRLTQVKENLKKSQAGGALGAPVEAKRPVRVNLLLCVCVEGIKNLFLVFLTCSCGIFLMLGDLYERKLSSKLHLFKKRFIRNLLPLLCSHPAKRSRTSTVILCL
The following text describes a protein:
Function:
May be involved in modulation of pathogen defense and leaf cell death.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
The C-terminus contains a calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion.
Sequence:
MMILYHLIHKSPPIKPTCSACNKDVWPVSEAKDSPNWQKVLGEELTKHLTTCGFKSNHRGRYLLHCGSSPIIFHFLLQDLSFILPLKMRKERPTDKGMSWLVKTQYISPLSTDATRLPFTEEQAKELRERRGNTLLDSHNSRKWKIKDIKVSFEACKSHPIHVTNKKLHPVEIFPLFPDFERNKHLQKDHDIFGDVDELLRQRKLGLERITRYDDSGEGKERRLEDEFERTQIGWTGDLRKVVKHIRSRSLGVPFFTTGKSLGANMMVKYLGANGDNILIDGAVAICCPWDLLIVLLLGAKLQVIITKMWLGIQERGEVVKGPLVEPTTYASWNNLSQVHEPSSVRVMAIFMPPPPAATYLAFHPQDNNIIAIGMEDTTIQICNVRVDDDLEFLFLCLSLHTHGSTFTIDHDPPGTGKPQTILGLLSAILHTN
The following text describes a protein:
Function:
The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins. Palmitoylates RAS2, which is required for its proper plasma membrane localization (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MNETKTDSTVNPDQSSQELVFFNYHEYLVPGSDDTSLVINHFPNIHTDLSSSTFKETRIIRIPRVYHTVQFPDLIPQFSCYYPGSEPGAITSTQLMSGSFDDNSFNESSSIPSLENIISRSEFENIVSLVNESLAVAFNPMSKRMLLENLLDLLSGGLFLSLLNFLGIYSFTKRKLMELESQIDSINQINEKKGVDFKIISPRVTGYLSLDFQITKPR
The following text describes a protein:
Function:
Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Sequence:
MATMVSSASGLLAMLNEQHPLLKLHALSNLNTFVDYFWPEISTSVPVIESLYEDEEFDQRQLAALLVSKVFYYLGELNDSLSYALGAGPLFDVSEDSDYVHTLLAKAIDEYASLKSKAAESSEEAAKVDSRLEAIVERMLDKCIMDGKFQQAMGIAIECRRLDKLEEAIMKSDNVQGTLSYCINISHSFVNLREYRREVLRLLIKIYQKLPSPDYLSICQCLMFLDEREGVASILEKLLRSGNNDEALLAFQIAFDLVENEHQAFLLNVRGRLSVPKSRPSEAVQHESSVTDSGQNGNPVTGNENITTPSEDVHMADETHGPNGNAHEMDPNEERYAKRLAKIKGILSGETSIQLSLQFLYSHNKSDLLILKTIKQSVEMRNSVCHSATIYANAIMHAGTTVDTFLRENLDWLSRATNWAKFSATAGLGVIHRGHLQQGRSLMAPYLPQGGVGSGGGGGSPYSEGGALYALGLIHANHGEGIKQFLXDSLRNTNVEVIQHGACLGLGLAALGTADEDIYDDVKTVLYNDSAVAGEAAGISMGLLMVGTASEKASEMLTYAHETQHEKIIRGLALGIALTVYGREEEADTLIEQMIRDQDPILRYGGMYALALAYRGTANNKAIRQLLHFAVSDVSDDVRRTAVLALGFVLYSEPEQTPRIVSLLSESYNPHVRYGAALAVGISCAGTGLSEAISLLEPLTSDVVDFVRQGALIAMAMVMVQISEASDSRIGTFRRQLEKIILDKHEDTMSKMGAILASGILDAGGRNVTIRLLSKTKHDKITAVVGLAVFSQFWYWYPLIYFISLSFSPTAFIGLNYDLKVPRFEFLSHAKPSLFEYPRPTTVPTTTSSVKLPTAVLSTSAKAKARAKKEADQKANAEKLSGEESAPVSTNLGKGKSSSEKDGDSMQVDSTSEKKAESEPAFEILTNPARVVPGQEKFIRFLEESRYVPVKLAPSGFVLLKDQRPTEPEVLSLTDTPSSMASPAAGGPATGQQGSASAMAVDEEPQPPQPFEYTT
The following text describes a protein:
Function:
Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Sequence:
MSLSFLLRVAGLFFLQFNSAQAKSQVHEQWHVSSIPNVPAGYTGSLHSGYLNLTDKLEGDLFFTLYGSENEVHQNRTIIWLNGGPGCSSEDGSMLELGPLRLTNDSLVYYNAASWVRLGNVLFVDQPMGTGFSFADTRDAILNDNEKMSNDFAYFLQEFVKAFPEYATDTWYIAGESFAGQYIPAIAKKVIDSDIVNLSGIAIGNGWIEPASHYLTYLDYLVERGLLERGSALFEALTAVQAKCLMSLEQSASGMLEDENSCDKYLFDILFSVSDKSGEFCFNMYDVTLTSPYPSCGMEWPLELPALTDFLSSPDVMKALHVASDKVSRWEECSSLVSNFYADTNVFRTRFTIAELLEEIPVMLFYGENDFLCNYVSGEFLISNLEWSGKRGFENASNADWYPRYSEANTLEYGQYAAAAGIIHSERNLTYATIRNSSHMVPYDHPYEMLALVSAFFDNDFSQILMLPDPVTIVPNHSFLSIFLWVMAGILAFSAIGAICYYSYRHIRSRYDSYTPIQEESA
The following text describes a protein:
Function:
Transcription factor capable of interacting with purine rich repeats (GA repeats). Acts as a master regulator of nuclear-encoded mitochondrial genes.
Subcellular Localization:
Nucleus.
Sequence:
MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVTMPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEEREALQKQLDEANREAQKYRQQLLKKEQEAEAYRQKLEAMTRLQTNKEAV
The following text describes a protein:
Function:
Required for vacuolar assembly and vacuolar traffic.
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network. Late endosome.
Sequence:
MSSARRGGHQHHNPLENGDGGEHEREEDDDEEDGEEEVGEDEEEEEEPRLKYQRLGGSVPAILSTDAAAAIAVTDRAVLLGTHDGTLHVLDFQGNQVKQIAAHTATINDISFADGEYIGSCSDDGTVVISSLFTDDKLKFEYHRPMKAIALDPDYSRNYKRFATGGLAGQVLVQTKKTWGGGYSKKVLRDGEGPIHSMKWRSDLLAWANDAGVKVHDMKMERGIAFIERPKGIPRSDFLVPHLVWQDDAVLVIGWGTSVKIAAIRTDLSPGYNGIQRSITTASSGKYVDIVGSFQTGYHISGIAPFGDLLVVLAYIPEEDSRDKKDNTSVPSRQGTAQRPEIHLVSWKNEELTTDALPIHGYELYKAKDYILAHAPFSGSSNAGGQWAAGDEPLYYIVSPKDIVVAKPRDTEDHIAWLLQHGWHAKALAAVEAGQGRTELLDEVGSRYLDHLIIERKYAEAAQLCPKLLRGSPSAWERWVFHFAHLRQLPVLIPYIPTENPQLSDTAYEVALVALTTNSSFHELLLTTIRNWPPTLYSASPVISAIEPQLNSSSMTEALKEALAELYVINKQYEKGLSLFAELLKPEVFEFIEKHNLHDAFHDKIVNLMILDSKRTVHLMIQHRDIIPPYEVVDQLLHASKSCDKKYLLHQYLHALFETDIHAGKDFHDMQVELYADYEPRMLLPFLRTSQHYRLDKAYEIFAQKELVREQVFVLGRMGNAKQALSTIINKLEDIQEAVEFVTEQHDDELWEELITQCLQKPEMVGMLLEHTVGNLDPLYIVSLVPDGLEIPKLRDRLVKIVTDYRTETSLRNGCNDILKADCVNLLVKYYHEARRGVCMASLDEEVGTRIDEGSSRTGDRSSSLRTLEIKSRTRCGARCCLCFDPLSIQDISAIVFYCCHAYHLSCLEGGLDSMKANNNARDSDEGSEDDDGSPSGESRMRCVLCTTAAA
The following text describes a protein:
Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MTSNVKEPDGPCNIDTIRQYVTPLNYPLEKMSDMAEEMRAECKEIVVNAIEKHEDSYELAARHIKEQMDKKYGPSWHCVMGEGFGFEISYEMKHLMYMFHKGYVAIVVFKGL