lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
Sequence:
MPQTKPIVSVENVVASASVDQKMDLNEITRTFPDVEYHPDQFPGLVFRLKSPKTATLIFTSGKMVCTGSKSEEMARKAVKTVVQKLRKGGIKVKKDAVVEIQNIVASINLGGKIHLEQAARTLPRSMYEPEQFPGLIHRMLDPKTVILLFSSGKLVCTGAKKEPDVYRSVNNLHALLEEKDLMIYD
The following text describes a protein:
Function:
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular Localization:
Nucleus.
Domain:
The F-box is necessary for the interaction with ASK proteins.
Sequence:
MASSSSPPAAMEVGESTNWTELPPELTSAILHRLGAIEILENAQKVCRSWRRVCKDPSMWRKIDMHNLGDLDDMDYNLEIMCRHAVDRSQGGLVDIGIWYFGTVDLLNYIAHRSSNLRSLRLIRCSQITDDGFVEAVVKLPLEELELSYCSFSVESLRVVGQCCLNMKTLKLNKHPQKENDDDALAIAETMPKLRHLQLCGNGLSDTGLNAILDNCSNLEHLDLRRCFNVNLVGDLQKRCFESVKVVRHPNDSIHDIDIGSSEDEDPYDFSDIDLMSGDDDFEGYYDFSGASDFSDYDQFDF
The following text describes a protein:
Function:
Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome.
Sequence:
MFIPSIYLHQQLHYCKTAILNWSRKMALSRQKFTFERLRRFTLPEGKKQTFLWDADVTTLACRATSGAKAFVFQSVYAGKTLRMTIGNINDWKIDDARAEARRLQTLIDTGIDPRIAKAVKIAEAESLQAESRKTKVTFSVAWEDYLQELRTGISAKTKRPYSTRYIADHINLSSRGGESKKRGQGPTSAGPLASLLNLPLSELTPDYIAAWLSTERQNRPTVTAHAYRLLRAFIKWSNYQKKYQGIIPGDLAQDYNVRKMVPVSASKADDCLQKEQLKSWFSAVRSLNNPIASAYLQVLLLTGARREEIASLRWSDVDFKWSSMRIKDKIEGERIIPLTPYVSELLNVLAQSPNSDVNKEGWVFRSNSKSGKIIEPRSAHNRALVLAELPHISLHGLRRSFGTLAEWVEVPTGIVAQIMGHKPSALAEKHYRRRPLDLLRKWHEKIETWILNEAGITIKNNVDMR
The following text describes a protein:
Function:
Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.
Sequence:
MCDQGKRKKKEKFQYNKSIMAATSVVVLDRGNNTTCTVNLHGATVVSWRVNNQEQLFVSKLAVFDGKKAIRGGIPFVFPQFGPWNFGPQHGFGRVVRWTLERAPERLPSGDVEAVFSLMDNEITRSMWNYPFRITYRLILREKELHFHIGVYNPSKDMTFSFNLLLHTYLKVPDVRRCQITGLHGCTFVDKTRDGAIYQEGRDAVTINEWTDRVYQHTPQEHIITNVVSGRKMRLQKYNFPDTVVWNPWMEKARECQDFGDDEYPNMICVEAGHVSTPVILLPGTAFEASQILQVM
The following text describes a protein:
Function:
Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.
Subcellular Localization:
Cytoplasm.
Sequence:
MASISPYGKRFISYLRREQIRRLLATKYRVDGRGPEQTRNVEINVGVVKTADGSAEVKLGKTHVVAGVKVGLGQPFPDAPDEGVLVVNAEVLPHASPYTEVGPPDEFAIELARVVDRGIRHCGYVDFKKLAVEGGKAYVLWIDLYVINDDGNLIDVANLASVAALKNTQLPVVVKDEAGVVKLDRNNKAPLPVDISKAPIAVSVGKIGNVLFLDPTFEEELSLDGRITFTFSEDKIVAAQKTLGYFTQSEIEAALNLALRGRDRLLEALKSALK
The following text describes a protein:
Function:
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MPVTVGEAASGLTSIVWKTKVKHVSQYHTNEKVQLNRFHPCAAYTVTCHLYSQTVNLKKNTYEIELYLVWHRQSTTLSGGEISVKPENHHRPFAIWGSVDGSDKFKLKELRGAGKKEWMSGLIPFKFSRSSKEKSLPLTCKFWVEFETFSRSQKNALKHVKDLYVQQSNCDVQFRFKGREQLGAHSVILAARSPVFAAMFQHNMKEAITGEVDIEDIQADIFDQLLHYIYSGRMSKPMTEASAHLLYAAADKYDIADLKKDCVKFLLSCVRVDNVLNLMIWSHNFSITKAKEATVAFAARHGKEICKLESWERLTKNYPGLSVLATRRMMENMFTLIIKPVVENPRKIQTEGGWGRKRTKEPCPAITNLILVKKIQSKQVVASNIRAVFRVSAELKMPFKVEQLDNNTSEVEWTVTIKPPNKKVDDETSLEETLQLFLYNSFELCKVTCYLSINQSKLGECTAFLRMEWHGNPTSNGLEGSSGGYRHLPCNISVSVDGSKRNPLKLVWVLKKSSWKSDALVISSNENGELNSSRKLPVNLIFQVKYEPSFCRGEKKALKLLTDIFVHQVDCDVQFECEGDRRIGGHSKILSARSQIFAGLFQKNTSENNADPIVIEDIAPEIFLSLLNYIYCGRISMPLTDETAQKLYVAASKFEIEDLEEDCIDYLLSCLTHDNVNNLITWSRQHSVEKLENAAHAFNEKELVASKKVDTAAATQKVIKNAPIKKSSVAPKSHPPYLAMVVEAIKTLKQNNKGSSRQAILNYILSSFKLGDDSKMANVHLKQALKKGVAQRVLFNTKGAHGAAGSFRLFNPQKDEVDIVAKNVTPEQFDPPTVKKAKLAASTSSTMKSSAVSVK
The following text describes a protein:
Function:
Probably a non-catalytic chitinase-like protein, which binds to insoluble chitin and enhances the activity of the catalytic chitinases. Has weak chitin-binding activity.
Subcellular Localization:
Secreted.
Sequence:
MTRLSFTVLIFLAAYFGSNIRPNVATLDPKTVCYYESWVHWRQGDGKMDPEDIDTSLCSHIVYSYFGIDASSHEIKLLDQYLMITLHDMEHFTKHKGNAKAMIAVGGASMSDQFSKTAAVEHYRETFVVSTIDLMTKYGFDGVMIDWSGMQAKDSDNFVKLLDKFDEKFAQTSFVMGVTLPATIASYDNYNIPAISNYVDFMNVLTLDYDGPWAYTVGHASALPEQLKTLEAYNKRGAPRHKMVMAVPFFARTWILEKMDKQDVGDKASGPGPKGQFTQTPGFLSYNELCVQIQAETNAFSITRDHDNTAIYAVYVHDNHAEWISFEDRHTLGDKARNITEQGYGGMSVYTLSNEDVHGVCGDKNPLLHAINSNYFRGIVTEPTVVTVTPVTHTTEHVTDIPGVFHCHQEGFFRDKTYCAKYYECKKGDFGLEQTVHHCPNHSQAFDEVSRTCVDHAKIPGC
The following text describes a protein:
Function:
Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MANEIITPTEGELKTIIDKTAAYAAKLGESFENKVKQREGHNAKFNFMKEGDQYYPYYRNKIVENKAKIQADAAAAAAAANPKTPSTTTTTTTTTTATTPLPTATATTTSPTPTTSSTIVPVPQTNSTQQLQQQQQQQQQTTPVFEKPQPPPPPPPKKEPTQPDPLLYILDVPDFMTPLELDTIRLTAQFIAKNGDSFFMELASREVKNSQFDFLKPTNHLYEWFRALVESYAQIIYPPQGIKEQLKSNYFSNKQTILERAMNRCEYNQLKEIEEQKKEEREDEEKTIIASIDWHDFVIVDTIEFNEDDLDDLPQPRTFDQLIAGDTPFGGSDFDNDGHGSNGKGGQDMEMEMDMEMEMDDEDNNNNEDEIEESSLSSTNTTGNLPPKDQSKLKIVKDYQKSNSSVKSNAPTKLTQLCQFCKQEIPLDEMQEHMRIELIQKQQRDSRLGGGGSSNNNNNLTNTLTQDDDIARNLQSFASKRVDIFGETESSKKQDEQPTQAPKVIWDGHSGSIPRVQAAQQAAQLAAQQAAQQKAAAIAAQQASQQQASQQQQQQLQPPQPIGIHHHPQRHLPPGMMPPGMMPPGMMPPGMMPPGMVPPPPFGMIPPGMVPPPPPGLMIPTAPPGLMIPPTQQQQLPPQTNTSPSSSSSIKVEEPQSKKLKIDDVLIPESVWLQNNPNPVNLTVEMADKSNIYQITLQPTDSISLLKEKIKELNGMPTNKQKLQAPGLSILKDTCSIAFYNLKSLAIVTCGQKKKGGKKK
The following text describes a protein:
Function:
Toxic component of a toxin-antitoxin (TA) system. An RNase.
Sequence:
MRFIDANVFIYAFLRPKKEPPENVRMMKEVAKEILKRVSEGEEVVTTVVHLSEVANVVESRAGKKRAAEILLTLLTMENLKVLDVSYGDYLKATLIAEEKNLGINDALAYVKMKEEGIGEIYTFDRDFEKLDIRVVLE
The following text describes a protein:
Function:
Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3 (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MMLSRPKPGESEVDLLRFQSQFLEAGAAPAVQLVKGSRRHGDAPPDRLPPQDHRDVVMLDNLPDLPPALLPAPAKRARPSPGHPLPHDEDPEERLNRHDQHITAVLSKIVERDTSSVTVTLPVPSGVAFPPVFHRSQERQVKPAASGKRSIFAQEIAARRVSGNRVTSAEQVVPSLDTPEGAVPCETPSFRDRSNQLPGRSHGFHRPNLVTGKGLRSKVAEQEVQTIHEENVARLQAMDPEEILKEQQQLLAQLDPSLVAFLRSHSQVQEQTGTKATKKQSPKRPSVLVTKEEPVTSTRTREPRTGDKLEEKPEATVEDKMEDKLQPRTPALKLPMTPSKDWLHMDTVELDKLHWTQDLPPLRRQQTQERMQARFSLQGELLAPDVDLPTHLGLHHHGEEAERAGYSLQELFHLTRSQVSQQRALALQVLSQIVGRAQAGEFGDRLVGSVLRLLLDAGFLFLLRFSLDDRVDSVIAAAVRALRTLLVAPGDEELLDRTFSWYHGASVFPLMPSQDDKEDEDEDEELETEKVKRKTPEEGSRPPPDLARHDVIKGLLATNLLPRLRYVLEVTCPGPSVILDILAVLIRLARHSLESAMRVLECPRLMETIVQEFLPTSWSPIGVGPTPSLYKVPCASAMKLLRVLASAGRNIAARLLSGFDVRSRLCRFIAEAPHDLALPPEEAEILTTEAFRLWAVAASYGQGGDLYRELYPVLLRALQTLPTELSAHPLQPLAMQRVAALFTLLTQLTLAASSIPPEPASGPAESCVPAIPSSVTWTQVSGLKPLVEPCLKQTLKFLPRPDVWNALGPVPSACLLFLGAYYQAWSRQSHLCPEDWLQDMERLLDESLLPLLSQPPLGSLWDSLRDCSPLCNPLSCASNPEALPSLVSLGCAGGCPPLSVAGSASPFPFLTALLSLINTLVQSHKGLCGQLSAVLTAPGLQNYFLQCVAPAPAPQLTPFSAWALHHEYHLQYLVLSFAHKAATLQPEPAASTALHHAVALVLLSRLLPGSEYLAQELLLSCVFRLEFLPESASGGPEAADFSDGLSLGSSGDPQCRRGALLVQACRDLPSIRSCYLAHCSPARASLLSSQALYCGELLRVSSLLLPVPKEPLLATDWPFQPLIHLYHRASDTPSGPPAADTVGVAMRVLQWVLVLESWRPEVLWAVPPAARLARLMCVYLVDSELFRETPIQRLVAALLARLCRPQVLPNLKLDCPLPGLTSFPDLYASFLDHFEAVSFGDHLFGALVLLPLQRRFSVTLRLALFGEHVGVLRALGLPLTQLPVPLECYTEPAEDSLPLLQLYFRALVTGTLRARWCPILYTVAVAHVNSFIFCQDPKSSDEVKTARRSMLQRTWLLTDEGLRQHLLHYKLPNSSLPEGFELYSQLPRLRQQCLQTLPTEGLQNGGVKT
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MNDSSTSNRKALFEEDKDLKVNKRADALLERKQQEAEFELEKLQAEERGEDFDRKRAWDWTVKETEEWKEKKERKRERESQSGVHDMSSTAQRAYEKDLASFKPDLETYEKEKETGLHHTPSFNHKPTPEALDRLVNGLTKGDKQRMKRRKQAGADDQHATYISDKNKQFNEKLNRQYDKYTKEIRDNFERGTAL
The following text describes a protein:
Function:
Transports either thiamine or, rather, a related metabolite involved in the thiamine biosynthesis pathway.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MKNMSQRSMDVEKKAANADSCSVSTSSINVDDADVALRFLKQNGLDESSTANEDDVVAGEEANFYGSHELSPKVLRKVDLFILPFLCCTYLLMFLDKALLNYAASMGIKDHLKGNEFSNLGTIFSAAYIFMEPVVTYLIQKFPISKILGTFITVWGIVLACHAACKTYASLMVVRTLLGLFESSSAVGCIAISGMYYTKSEQSARIGFWATQAGTGYIVGGLISFGFLHYHGTAFTSWQIMFLVVGLVTVAFGVLTFLYLPDNVTNAWFLNKEEKIQVVEHIRANQTGLETKKFKKQQVKELFLHDKFTWPMLLLTACSQISTGAIGTFSVTITGTFGFDKYETALLQLPIGAITAMIILITTQMLSRWGHITLITTSMYIPAIIGCIVLISLPLSHKIGNLFSLYLLYSGSCVITNIYIWNSCNTSGYTKRVFRNAITMIVYNVSCIIAPQMFRAYSAPRYIPAKIALLVTQCVCVPLQLYIGYICKKENEKRDKEQEGQERKKYQFLDLTDIENRNFRYIY
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MDSRKQNEREDSELSSIVEESGDGNTEATIRQTQEEIMAGATKGVYIPQRDKDEAREARRILRGYEERANEMKENASLTTAEEFDRQVLGLDDAFNTQVRAPADATIDSRALRLYSETGLKKAKLLKTDLRGFEPDEFVFRFKQVMAPSIVASLMGDDGNGQDGSEAIDWFEAGRRLMPFSRRVPTMDLMYGPLGIQLKKRKHYPRGSLEKHESERKEPEVIFELLPAEINLFQFFINPGSFAQSVENLFCLSFLVKDGRAIIQTHDEHQIEREFPVVSSTESVGHEVLERNFTNAQIILEFTMQNWEDAIELYGIKSSIIPDRKQPTSSGKWH
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYHYYYEYLKSSRYLRIFCTLPVTYDKNRKPRPRFRPFPFLWFYAFALVFQFSIMSFAATDIILELRTEKVTKVAVKLVKIAVTLDILVVVYKSRNKFVDCMNSVLYYEEQAEKNNIVMRYRYSLRILLLMKKVMVLSTSFIGNLSCFMTGNTYISCVVSFITYNVTYLISSIVLTQFCGLILVARQHLIFVNRALFNLSKDPQQAIEKMNELMTYHFEVCDMTIKINQAFSAHLLLIIVRTFVEFFNSLHSIVKEKSHLLVMYDFFWSTCAIFEFIFMLFACKRATETVIKLGSFVLRFLIKRWLQCSRTGRILNLLQTHNNNKLNLLRNVFLLQIRHKHVTFSANSLFSIDNKMFLHLISTSVAYLLIIIQFEKE
The following text describes a protein:
Function:
Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm: upon activation by the TLR adapter MYD88 and subsequent phosphorylation, translocates to the nucleus.
Sequence:
MNQPAPAALLPPRRVRLKPWLVAQVNSCQYPGLQWVNGEKKLFYIPWRHATRHGPSHDGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKVYEVCSNGPAPAESQPSEDNAEEEEEEELQKMLPGLSITEAVQPGPAMAPYSLPKEDVKWPPTLQPPVVLAPPAPGPNLLVPAPGNAADFGEVFSEVLPSSQPQPGSLSTSLAPTGEQLLPDLLISPHMLPLTDLEIKFQYRGRPPRALTISNPQSCRLLYSQLEATQEQVELFGPVSLEQVRFPSPEDIPSEKQRFYTNQLLDVLDRGLILQIQGQDLYAIRLCQCKVFWSGPCASAQGSHPNPIQREVKTKLFSLEDFLNELILFQKGQTNTPPPFEIFFCFGEEWPDCKPREKKLITVQVVPVAARMLLEMFSGELSWSADSIRLQISNPDLKDRMVEQFKELHHIWLSQQHLQPVAQTPAMPGLSAAQGPWPMHPVGMQ
The following text describes a protein:
Function:
Attaches the virus to the human SLAMF1/CD150 receptor for entry into host dendritic cells, macrophages, activated memory T cells and naive or memory B cells, thereby explaining the long immunosuppression that follows infection (By similarity). In the respiratory airways, binds to the NECTIN4 receptor for entry into the host cell. During viral entry or virus-mediated fusion between infected cells and neighboring susceptible cells, the head domain of the H protein initially binds to its receptor and then the stalk region of the H protein transmits the fusion-triggering signal to the F protein. Unilateral receptor binding to only one of the covalently linked dimer pairs in the H tetramer is sufficient for F triggering. In case of neuropathogenic strains, host CADM1 (isoform 5) and CADM2 (isoform 5) can interact with measles hemagglutinin to trigger hyperfusogenic F-mediated membrane fusion and presumably transsynaptic cell-to-cell transmission of the virus.
Miscellaneous:
MISCELLANEOUS: Infecting host innate immune cells allows the virus to disseminate from the upper respiratory tract to lymphoid organs, and later back to the respiratory tract.
Subcellular Localization:
Virion membrane; Single-pass type II membrane protein. Host cell membrane; Single-pass type II membrane protein.
Sequence:
MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLEARATNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLSRGYNVSSIVTMTSQGMYGGTYLVGKPNLSSKGSELSQLSMHRVFEVGVIRNPGLGAPVFHMTNYFEQPVSNDFSNCMVALGELKFAALCHREDSITIPYQGSGKGVSFQLVKLGVWKSPTDMRSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKNQALCENPEWAPLKDNRIPSYGVLSVNLSLTVELKIKIASGFGPLITHGSGMDLYKTNHNNVYWLTIPPMKNLALGVINTLEWIPRFKVSPNLFTVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDKKLWCRHFCVLADSESGGHITHSGMVGMGVSCTVTREDGTNRR
The following text describes a protein:
Function:
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
Subcellular Localization:
Nucleus speckle. Cytoplasm. Nucleus.
Sequence:
MVWSRDQRRKVALENPQMQNSEISKQLGCQWKMLTEAEKRPFFEEAQRLQAMHRE
The following text describes a protein:
Function:
The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MWRPVQLCHFHSALLHSRQKPWPSPAVFFRRNVRGLPPRFSSPTPLWRKVLSTAVVGAPLLLGARYVMAEAREKRRMRLVVDGMGRFGRSLKVGLQISLDYWWCTNVVLRGVEENSPGYLEVMSACHQRAADALVAGAISNGGLYVKLGQGLCSFNHLLPPEYTRTLRVLEDRALKRGFQEVDELFLEDFQALPHELFQEFDYQPIAAASLAQVHRAKLHDGTSVAVKVQYIDLRDRFDGDIHTLELLLRLVEVMHPSFGFSWVLQDLKGTLAQELDFENEGRNAERCARELAHFPYVVVPRVHWDKSSKRVLTADFCAGCKVNDVEAIRSQGLAVHDIAEKLIKAFAEQIFYTGFIHSDPHPGNVLVRKGPDGKAELVLLDHGLYQFLEEKDRAALCQLWRAIILRDDAAMRAHAAALGVQDYLLFAEMLMQRPVRLGQLWGSHLLSREEAAYMVDMARERFEAVMAVLRELPRPMLLVLRNINTVRAINVALGAPVDRYFLMAKRAVRGWSRLAGATYRGVYGTSLLRHAKVVWEMLKFEVALRLETLAMRLTALLARALVHLSLVPPAEELYQYLET
The following text describes a protein:
Function:
May be involved in recombinational repair of damaged DNA.
Sequence:
MTRKARTPKAAPVPEAVAVVEPPPPDAAPTGPRLSRLEIRNLATITQLELELGGGFCAFTGETGAGKSIIVDALGLLLGGRANHDLIRSGEKELLVTGFWGDGDESEADSASRRLSSAGRGAARLSGEVVSVRELQEWAQGRLTIHWQHSAVSLLSPANQRGLLDRRVTKEAQAYAAAHAAWREAVSRLERLQASQRERARQIDLLAFQVQEISEVSPDPGEEEGLNTELSRLSNLHTIAQAAAGGVELLSDGDLNAAGLIGEAVRALNAGAKYDETVMQLQNELRAALESVQAIAGELRDVAEGSAADPEALDRVEARLSALSKLKNKYGPTLEDVVEFGAQAAEELAGLEEDERDAGSLQADVDALHAELLKVGQALDAAREREAEPLVDSLLAVIRELGMPHARMEFALSALAEPAAYGLSDVLLRFSANPGEELGPLSDVASGGELSRVMLAVSTVLGADTPSVVFDEVDAGIGGAAAIAVAEQLSRLADTRQVLVVTHLAQIAARAHHHYKVEKQVEDGRTVSHVRLLTGDERLEEIARMLSGNTSEAALEHARELLAG
The following text describes a protein:
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Sequence:
MAAGLQVFGQPASTDVARVLTCLFEKNLEFELVRIDTFKREHKLPEFIKLRDPTGQVTFKHGDKTLVDSRAICRYLCTQFPEDGNRGIYGTGSLERASIEQWLQAEAQSFDAPSSELVFHLAFAPQLNMLPDEARIAENERKLQQMIGVYDEILAKNQYLAGDEFTLADLSHLPASHYIAGSQRGRKLFTSKRHVARWYDAISSRPSWQQVVKMQHEHPGTFE
The following text describes a protein:
Function:
Member of the two-component regulatory system KdpD/KdpE that regulates the transcription of a series of virulence factors through sensing external K(+) concentrations. Also regulates capsular polysaccharide synthesis. Upon phosphorylation by KpdD, functions as a transcriptional regulator by direct binding to promoter regions of target genes including spa, hla, aur and geh. Represses the transcription of kdpFABC operon.
Sequence:
MQSKILIIEDDHAITHLLDVALTLDYYNVTTADNATQAHFKIQIDKPDVILLDLGLPDKDGLCLISEIRQHTDIPIIVISARQEEQTIIQALDNGANDYMTKPFNVDELRARIRVIERIAKSHQETNIVFTNGLLSIDFGSKSVVINNQEVHLTPNEFSLLELLSNHKGKVLTYEMILKRIYGYVNKTEMPSLRVHMTSLRQKLSQCHEDAKDIIKTHPRIGYQMLQWKEK
The following text describes a protein:
Function:
Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Predominantly nuclear.
Domain:
Contains an N-terminal anti-parallel coiled coil formed by two BRMS1 chains; this region can form homohexamers.
Sequence:
MPIQPSGKETEEMEAEGDSAAEMNGEADESEEERSGSQTESEEESSEMDDEDYERRRSECVSEMLDLEKQFSELKEKLFRERLSQLRLRLEEVGAERAPEYTEPLGGLQQSLKIRIQVAGIYKGFCLDVIRNKYECELQGAKQHLESEKLLLYDTLLGELQERIQRLEEDRQSLDISSEWWDDKLHSRGSSKTWDSVPPSKRKKAPLVSGPYIVYMLQEIDILEDWTAIKKARAAVSPQKRKADGP
The following text describes a protein:
Function:
Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (By similarity). Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity).
Subcellular Localization:
Nucleus. Nucleus, PML body.
Sequence:
MAWDMCNQDSVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSDQSEIISNQYNNEPSNIFEKIDEENEANLLAVLTETLDSLPVDEDGLPSFDALTDGDVTTENEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHANHNHRIRTNPAVVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTNDDPPHTKPTENRNSSRDKCTSKKKAHTQSQTQHLQAKPTTLSLPLTPESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFRASPKLKPSCKTVVPPPSKKARYSESSCTQGSNSTKKGPEQSELYAQLSKTSVLTSGHEERKAKRPSLRLFGDHDYCQSINSKTEILVSTSQELHDSRQLENKDAPSSNGPGQIHSSTDSDPCYLRETAEVSRQVSPGSTRKQLQDQEIRAELNKHFGHPSQAVFDDKADKTSELRDSDFSNEQFSKLPMFINSGLAMDGLFDDSEDESDKLNSPWDGTQSYSLFDVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCYYYESGHCRHRTHRNSPLCASRSRSPHSRRPRYDSYEEYQHERLKREEYRREYEKRESERAKQRERQRQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDPACIKSKYDSLDFDSLLKEAQRSLRR
The following text describes a protein:
Function:
NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability.
Subcellular Localization:
Nucleus.
Sequence:
MSSLRAHQKKNPTPTQCQNQTTLDSICKDIQTGKITRIVALVGAGLSTSSGLADFRTPDTGLYAKLEPLQLPYPEALFHISYFKHTPEPFYAIARGRHPWNTKPGVGHAFLALLEKKGVLGFVFTQNIDGLELDAGVSRERVMNLHGDWSDQHCIKCRSSYPADRMRKAILTGEVPFCVQANCEGIVKPAIVMFGESLPEGFDSREEEMLSTADLLLVIGTSLKVAPCSEIPRRLPSHVPRVLVNRELVGNIGTRESDVCLLGDCDAWLREVARHLGWDEELESVWKDTLVRKEKSSRDKGWDDKAEQSPTLEECIVRAAEQMKVRMGVSEGHRRMLEGHLGEKMAEIMAKRGQ
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKKENWQKIENVYLLGKKIDKAKRMANKGESNTNMLSTEENIVKAKAVSRKKPVDVSYAGLARHESHVDTDYHGQALNTDNQDPKNYQARSFVKENELYESSQDCGHSRLAQILSEENQIKRLPQSDNTTTERIIENNPNYSNKPSKLKRALSGENSVFSIHQRNTLSPSSNLPRIPSDLYDIKQFLENLDARSFKSDMDLKRSQNMRRRATGYPAIVVPFLNGSLPQADLPPLRTIEDIDNLTREQCLTFIQGYGIPIDSSDTVYLKEKLRDAIGMRAFTDMSFEMNSFHLESPR
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme. Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear.
Sequence:
MASSFTANQYEDAFKSQKLQSWTIPKQFKERPSRLDGHTQFIVNDRGHLLPGLKSKKQTAWGSYVGTWDLPRRISPGYINYTARSEGGVAKLRTWVERNSFSINSRAEKEKMNKDPQTPINQEEIQQPEASPRPPSLEGAPATSRPATQEKTDSPQQEASLLPPTAEKPTSEAN
The following text describes a protein:
Function:
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC). During the base subcomplex assembly is part of a NAS2:RPT4:RPT5 module; NAS2 is released during the further base assembly process.
Miscellaneous:
MISCELLANEOUS: Present with 846 molecules/cell in log phase SD medium.
Sequence:
MEEEELSKLLANVKIDPSLTSRISQIDSFKLSELMVLKTDIETQLEAYFSVLEQQGIGMDSALVTPDGYPRSDVDVLQVTMIRKNVNMLKNDLNHLLQRSHVLLNQHFDNMNVKSNQDARRNNDDQAIQYTIPFAFISEVVPGSPSDKADIKVDDKLISIGNVHAANHSKLQNIQMVVMKNEDRPLPVLLLREGQILKTSLTPSRNWNGRGLLGCRIQEL
The following text describes a protein:
Function:
Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MTSLLFLVLISVCWAEPHPDNSSLEHERIIHIQEENGPRLLVVAEQAKIFSQRGGNVTLPCKFYHEHTSTAGSGTHKIRVKWTKLTSDYLKEVDVFVAMGHHRKSYGKYQGRVFLRESSENDASLIITNIMLEDYGRYKCEVIEGLEDDTAVVALNLEGVVFPYSPRLGRYNLNFHEAQQACLDQDSIIASFDQLYEAWRSGLDWCNAGWLSDGSVQYPITKPREPCGGKNTVPGVRNYGFWDKERSRYDVFCFTSNFNGRFYYLIHPTKLTYDEAVQACLKDGAQIAKVGQIFAAWKLLGYDRCDAGWLADGSVRYPISRPRKRCSPNEAAVRFVGFPDKKHKLYGVYCFRAYN
The following text describes a protein:
Function:
Component of RNA polymerase I core factor complex (CF) that acts as a sua7/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds HomolD box in rDNA promoters and plays a role in Pol I recruitment.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
Although it shares weak sequence similarity with sua7/TFIIB, displays a similar subdomain organization as sua7/TFIIB, with a N-terminal zinc finger, a connecting region (composed of B-reader and B-linker regions), followed by 2 cyclin folds.
Sequence:
MEGNWFEGPPCSVRNCKSTWYFKNAGQTFCRRGHAQHGIEIAQDDEPGAGTFYQTRKRKVVRNHLDTGDEDEIVYGTAGRSLYLQAFQIILQLQCQALTTKLGFDQRIEGMIRDLWALYLSLSYESFTSSFLSLNQNSTQSESSDSDFDLIDPESQPGADPSSRKTKETSQSHSISYPRLLYSSAFIYVACLLLRLPLTIHKLEVLIRKNIIPYYRAYKQIPLKIFKRLQKNYVRMLIPFHYPTYQRIQSAVLTLVDVLVSKYELKVPPPNEPLILFELINSFFFPLEIFIPASRLLNLVHSQISLQGTSSDNYQSKIRSAQSIHEKLSDAEVMLLATILVAANVCYGFDDAQTRNSKYKDSMFTVKTNWNMWLSQVQKINEKEKDKFYEIDEQSILTLNNSEMDKYFQWYEKEFVEENNPNNIPEGILNVFPILSKDSHLQENQPTDILTDESVIAEDVKLEQVFKPVGIKESDKMDFSRRKDAYISMLPFSPNTENTAHRVTIMVAKLYNIKLDSLIAAIRYVESCLKTGIHNQD