lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.
Subcellular Localization:
Nucleus.
Sequence:
MGRGGGGGAPGAGQWDEAAGPPRFESGGVEGGAGGGWVPGVFRRRRPGMAERLDHLKKYYRARFCGQGGKKINIQPGQNVLKYIQDCFECDDTDVTINSPNATSSSTPLVRNQERTSTQSPRPDAGLTIVVGNRTCHSTVSLPATPAETVRSKGEPCVFCPEPGRNSRIADSIKTDSPVHRGETQVLTFKDVEGLCESPAKLSDPEDDPGVVGSPLLVEEAKTPVQTRTVSIAPSSPSPVKDHNVEIESDCEFLIDESGCLSFKSWFSIPRKNRKSQKDGSAAPVLKSQSSDKEKTADKKGKNMNVQAEVHSEQKTKNVRVQRDLKRTSESHPVSSDSEGKVLKSKMQSSTHAGKSKKDALKGSSKHRKKMSYESEAEQLMLSGLDSETSDGEQKIRRVMPREDLAVPSAEHQQEQMLSSKKNLTPCKYQQSASKAYQRSVHKKQTKQTLANDTVLKSQRKKLKKSGKRNGNKNPEPRRWKSSDSEPGEEGLEREPLESNEMFTSPPHQELQTSVLQKLAKSEKAEKVLHALESVTDVNNKTPLKAVELLQHLVDSMKNSEKKRSSVTSSGKMLKKVHHRAHKRACSITRDSEPQNTTDSDSSSAPEVARKKRRQSAVRASKKPKSNRHQRLQHSPAAEKAMGPESGLVLEHSEKYTSPSKHCEENNESSDNSEDLHCQIKNLLSDEIGRQKIVLPSNTPNVRRTKRIRLKPLEYWRGERVTYTLKPSGRLLISGIAGAEAEPHMKNKLKSRHKKKRAKTRSEVVKCLDIPLADASKPTSIVDPVTNQEVLLECINSGSSHSCFFEDESIKVYKSLNTSDFAAGKLILKPLKEKGHQFVHMDTIAFYVIRGQIITTLHKTSYYLTSGDYFYVPAGNGYNIRNLLNEESVLHFTQLKNDSPTLGIERLLSGHLEAFSSLSLSS
The following text describes a protein:
Function:
Involved in the biosynthesis of cardiolipin.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSDIELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLLLDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIGGFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQQGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSVRIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANFDKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGRALSYFL
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MFNLYHQDDPYKDELEDIEEALLGSRFSDFDEMEDFYRSKYPSSKCNNSWFKDCLSFNCEECRLSSNSCICYDCFRHSNHEGHHVKCHINQSGNCDCGDTNFWKEESFCTKHHKQSEHPEALLTEQEQSDFFIAFSTAALFLQDAPNSGALTIIRWLKRFTTFGDPVLRCFSMAICPACTVELHLRLHSDALTALLALESSIVNEIYFDRTFLPYLLSELPKILKAPIRDENENIAGFFFHCYSSVIIDIFLRDSSWISSVREALFALYDLYSRVTNCHSYTQSAISSFISEYQSFIQRIVQKPEVTDEQKRMLGDVYIDYLELFPYRVNFNRIPTGDKVDDDEEDPTIVHLLTLCYIDYCTITLAPYLDKERMLISLYKLHKKQPISDNNCPANPENTVHLMQVLCVSTYIALVDAKEFRPIFENAAKKLDVSLDDFCSVIASLPMRAFVGHYYSEKNFFARNATIISIAFRVLHSDNCIKDIWVPMFGMVQICAGIMSTEKFLELVDSTFAVERDDADYIHFLTTISLQRLGFDYSDLNFLKILTFIMIRIRPIPLHYVLNRLYINTSVVDINKEIREICNKFESDDVFVRLKDENFLPYYNSFFNLPLLREMIQVFTSKNKASLFPLTVDSDYNDLKLLRYICTKKWNYAAENLMLKNDTDMIHFLMPVFVLKHQKSAEIIKDEPKKEIFETDLKELFMTKQEGKLFKMISQLGIPGEEFLRRINVGEIKMNEDTINEKKKIAREMRLKAIAEMQRQQSSFLGNIDDESSDDENMDEDICPICQQPNDLKSQDIVGFPVLATYGPTETYGFNFTIPQIRYFPCNHHLHRKCVPAMLFDCPLDRGHCNAICPLIPDDVDECNITNSNLANACFEFLDNIHADIRNALDGIINEIAVLEFRHLINPNCFMGYNFTGLRNIWRVIRLVIKYDHLYSDPPEVIETESGPRELPEYYCHEIFYSLACLENQDYKDIKKFTLELLKSHNEMNPVVLRRLAIFYQFILKIELVKQNEMKDVDWDEVLDINNLLDFFEIKDENDRKQFLNYKDSTNRVSLKIRLPKTIIDFMEPPFEINIANKIQTYLVLDGNNAGEIVSANQLSRLLMNPFNLLIDVSADRLSSVLVFGHKSYYALPSPYINDYGDEDIGMTQGFILKLDQQRFEKLLDIWFSAKYARIIYLDGL
The following text describes a protein:
Function:
Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MKKKLVVLGLLAMVLVLFIVVLCLWLPSASKEPDNHVYTRAAVAADAKQCSEIGRDALRDAVSAVDAAIAALLCVGLMNAHSMSIEGGLFLTIYNSTTHESEVINAHEVAPRLAFASMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLWYVFCRDRKVLREGERLTLPRLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGEANMAGLCPLSLQGIPSPALSPCHQISMSSLSFPIRPHSAASHTAHHTLLEFSFCKFFAPTKMLKNPKTVVRNMTSEFFAAQLRAQISDNTTHPISYYKPEFYTPDDRGTAHLSVITEDGSAVSATSTINLYFGSKVCSLVSGILFNNEWTTSFGVPPSPANFIQPGKQPLSSMFPTIMVGQDGQVRMVVGAAGGTQITTATALTIIYNLWFSYDVKRAVEEPQLHNQLLPNITTVERNIDQAVTAALETRHHHTQIVSTFIAVVQAIVRTAGGWAAASDSRKGGEPAGYWLLQADKADKQPRDKILTXXXEEHRLHTRLLPNITTVERNIDQVGQGLEKLSHGVGPQSILGWRPGSSQSGQWLVSSL
The following text describes a protein:
Function:
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the circadian clock through its control of the stability of the SCF(FWD1) complex.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAAATVNPLMSTLKSDSSLQVALHPLPILEISDYITRSYLRGYKGAIVGALIGQQNGRQITIEHSFSVKTEHTGQNYKVDSEWFTARLDQMKAVHKDRALDFVGWYTLVPKSGPTDAHLPIHSYFYSQNESAVLLGFHIHEILNPVAGDPLPLTIYESNLEIVDGTEASTVEVEGEDREMKDVTAEPSRSIKFRELPYTTETGEAEMIALEFVREGGSANVTTTATNITATEDEGSDKPLMKKVVDTNKGSKRRAVSSDDAAAEAPTTSSAAKGTATDKNRDANLTKAELDYMSALQAKYNAVQMMKKRLDTVISYLQRLPPDYLSSGDASSQQQQQQQQQQQTEGLDQPQYTVPSNKILRQIQALVTNVQLVMSNSTSGQGQGQGERDTDLGALEKELLKETNDVKLVELIADLMSSVKDMKEVGKKFHVVETAKNSKRREQASHGGGERFNPHHPYPGGGGGSSMMREHAGLVGEGSASGSGGSGPAGDLARFDH
The following text describes a protein:
Function:
Involved in the ornithine fermentation pathway. Catalyzes the oxidative deamination of (2R,4S)-2,4-diaminopentanoate (DAP) to yield 2-amino-4-ketopentanoate (AKP).
Sequence:
MEKVKVIIMGLGAMGGGMADMLLKKQGVEIVGVVGRGKMLGTSMYDHISTPRGDREDVIVGAMEDVITEKAADVVLLCTDSFTRKAFDKIKFIVEKKINVISSAEEMAYPMAQEPELAKEIDRLAKENGVSVLGTGINPGLIMDLLVILMTGCCEEVHSILSRRVNSLSPFGPAVMEEQGIGITVEEFNKGVQEGTLAGHVGFHESIGMIADAIGWKLSAPITQSMEPIVTDVDRKSPYGFAKAGNVAGCAMKGFGYVDGELKIEMDHPQQIEPEQVGVQTGDYVIINGVPNINMVNSPEVPGGIGTIAMCVNMIPQIINARPGLHTMIDLPVPRAIMGDFRDLISEEAKIVK
The following text describes a protein:
Function:
Potential alternative pore-forming subunit of the epithelial sodium channel (ENaC), capable of replacing the alpha/SCNN1A subunit, creating a more active channel with distinct properties. ENaC functions in epithelial tissues, where it facilitates the electrodiffusion of sodium ions from the extracellular fluid through the apical membrane of cells, with water following osmotically, regulating sodium balance and fluid homeostasis. This subunit could also function independently as a sodium channel or assemble into other tissue-specific heterotrimeric sodium channels.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein.
Sequence:
HGVCWRDPGRTDAARPGGAAQTPPRLGPPSAPPLPPKEGHQEGLVELPASFRELLTFFCTNATIHGTIRLVCSSRNRLKTTSWGLLFLGALVTLCWQLGHLLEHHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPRLVLRHLELLDEFARENIDSLYKVNFSKGRDALSAAVPRREPRFHLDREIRLQRLSHSGSRGRVGFRLCNSTGGDCFYRSYASGVAAVQDWYRFHYVDILALLPEVWEDSHGRQDGHFVLSCSYDGVDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGIGLVLRVEQQPHLPLLSTRAGVKVMVHGRNHTPFLGYHSFSVRPGTEATISIREDEVHRLGKPYSHCTSGGEGVEVELLHNTSYTRQTCLVSCFQQLMVETCSCGYYLYPLPTGAEHCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSSGTSRWPSAKSAGWTLAALGEQGLPRQSHRQRSNLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDTLALTLLLGGRRLRRVWLSWPRASPASGASNIKPEASHMPTPAGATSDNLGPSGPHLPQMMLPGALERVSAEESWAGPQPHETLDT
The following text describes a protein:
Function:
Putative chaperone involved in protein folding. Interferes with propagation of [PSI+] prion when overproduced.
Miscellaneous:
MISCELLANEOUS: Present with 125 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQQNTSLYDSLNVTAAASTSEIKKAYRNAALKYHPDKNNHTEESKRKFQEICQAYEILKDNRLRALYDQYGTTDEVLIQEQQAQAQRQQAGPFSSSSNFDTEAMSFPDLSPGDLFAQFFNSSATPSSNGSKSSFNFSFNNSSTPSFSFVNGSGVNNLYSSSAKYNSNDEDHHLDRGPDIKHNLKCTLKELYMGKTAKLGLNRTRICSVCDGHGGLKKCTCKTCKGQGIQTQTRRMGPLVQSWSQTCADCGGAGVFVKNKDICQQCQGLGFIKERKILQVTVQPGSCHNQLIVLTGEGDEVISTKGGGHEKVIPGDVVITILRLKDPNFQVINYSNLICKKCKIDFMTSLCGGVVYIEGHPSGKLIKLDIIPGEILKPGCFKTVEDMGMPKFINGVRSGFGHLYVKFDVTYPERLEPENAKKIQNILANDKYIKAERSTMETADSDCYCDLEKSYDSVEEHVLSSFEAPNLNNEVIEDDDLGDLINERDSRKRNNRRFDESNINNNNETKRNKYSSPVSGFYDHDINGY
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVQLNNRRARGRPTRNSLKTEILSKVKLNRNKQSTTNSTTRNPSEHKPNSQSNSEIQALHLTQESSAAVSSSSSSLIEDVPAEIKRKTDQSKVSSDATDKKAKPSKQKSNESNDRGKRKDSVAVVVEGDDDDEDGDQEEENKKKIERLIRKHSKKIKDEPSKLISEFHRIEKRLSQPKLDPLTRHRLILEQKKLGGLEAYQTASKIGGALENGGETGKWCAQTLIELGFRPSGPPPTINKVTLLDVGAIDGKSYAKYTDWISTTSIDINPIDESVVARCDFFKFPLPKTEEQKFDVVCLSLVLNFIGDLKKRGEMIKRARRFLKPSGKLFIVLPLACLNNSRYLDFKRFRMILNYLGFKVIKQHNSSKLTYWLLEKEDLQSNTIDHPTESDPTTNSNHSKSSLKFPKVQIRPGLSRNNFCIKV
The following text describes a protein:
Function:
Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.
Subcellular Localization:
Nucleus. Chromosome. Cytoplasm.
Sequence:
MTEVLDLHGQDSDGGSEEMVLTPAELIEKLEQAWMNEKFAPELLESKAEIVECVMEQLEHMEENLRRAKKGDLKVSIHRMEMERIRYVLSSYLRCRLMKIEKFFPHILEKEKVRSEGEPSSLSPEEFVFAKEYMDHTETHFKNVALKHMPPNLQKVDLLRAVPKPDLDSYVFLRVKERQENILVEPEADEQRDYVIDLEVGSQHLIRYKTIAPLVASGAVQLI
The following text describes a protein:
Function:
Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAASIGISFGATSACLATQKDGKADVVANEDGQRVTPAMVANTDTEMVVGLAAKQGWIRNAANTITKVKQILGKKFADPAVEHAVKTSSCKIVEKDSNPMYAVQHNGKTKHFSPTHITTVIFRKLMDIAQSKEMSGGKNAVVAVPLNFDEQQKDAVRRAATEAGFHVLRTIPEPVAAAYAHNIGQESPKDSRVALVYRVGGSSIDATVLAVSGGMYRVCGCEWGDVPSVWLVALVYRVGGSSIDATVLAVSGGMYRVLASVRRDHLGGDQLNRIIVDYFVQEFKRKWKADVTENTRAMAKLNTEAEKAKQILSTMPKASCHVESLHEGIDFQCDISRARFESIALSLLQQCLEPIEEAISQAEVKKQAINMVVLCGGSTKIPKLQKLVQDCVQQAEVLNSVSPDEVIAMGAAKQAALLSGKGEENALNEAIAEIPSTARAVMLKVCFLSDKEDLYLYLSTVDDSGSPVLKTLVPARSPIPLHCQHTFPVSQQLSACCVELYEGEQDDTVEKAVLLAKIVLSDLPTGDDDVKVVSVVLHFRREGSLHVTCTEKCSGQADDVTIECATE
The following text describes a protein:
Function:
Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MKFSPSKIQSRLLLALLTITVHFAGWVQGQVAPPTRLRYSVLTHDSIQISWKAPKGKFTGYKLLVTPNSGGKTNQLTLQSSATKAIIQGLLPEQNYTVQIIAYFKDKESKPAQGQFRIKDIEKKKDPSKPKVKTSEKTNGSRPTHPAAENQFICRSPAIADIVILIDGSWSIGRFNFRLVRLFLENLVTAFDVGANKTRIGLAQFSGDPRIEWHLNSYSTKEEVIDAVRNLPYKGGNTLTGLALTYIFENSFKSEAGARSGVSKIGILITDGKSQDDVIPPARKLRDTGVELFAIGVKNADLPELQEIASKPDSTHVYNVADFNLMHTIVEGLTQTVCTRVEEQEKEIKASFVANVEAPTDLVTSEVTARGFRVDWTQAPGRVEKYQVVYYPTRGGKPEEVVVDGTESTAVLKNLMSLTEYQIAVFAIYNNSASEGLRGSETTLSLPLVSHLTLYEVTQNSLRAKWSQVPGASGYLVLYAPLTQGLAGDEKEMKIGETITDIELTGLLPDTEYTVTVYAMFGEEASDPVTGQETTLPLSAARSLRLSDIGHNSARVTWDPDPEATNGYRIKYGKPDGTETNEVDVDLVSTYVLEELDPLTEYSIVVFSLDDEGELEPLIGRFTTKQTPALRPLKIDAMSPSSLRVRWRPLSPDVARQRLMWVPLAGGEAEEVILKGQTNVHVIDGLLPNTEYQVSLLAVFSDDRESSVAVGIGTTLDDATVEPTVPVTTLAPSGPVTSGIRNLVVVPESSSSLRVTWDISDSGVRQFRVTYVTTGGDHAEEVVETVMVPGRQNTLLLQSLLSDTEYKVTVTPVYSDGEGVSVSAPGKTLSLFAPGNLQISEEWYNRFRVTWDPPPTPTTGYKVVYKPTNSTDPALEIFVRDYVHTILLQNLAMGTEYNVQVFASYSPDFSDALTGVAQTWLLGVTDLDTYQAQATSLCAHWKLHNHATAYRVVIESLQDRQKQETVLGGGTARHCFFELQPNTEYKISVYSQLQDIEGPGVSMMEKTLPFPTQPPAISSTSPSPTIPPAKEVCKAAKADLVFMVDGSWSIGDDNFNKITTFLYNTVGALDKIGADGTQVAIVQFTDDPRTEFKLNSYKTKETLLEAIKNIAYKGGNTQTGRAIKHARDMLFTVESGMRRGIPRVIVVITDGRSQDDVDKISREMQLDGFSIFAIGVADADYAELVNIGSKPSARHVFFVDDFDAFQKIEDELITFVCETASATCPLVHKDGSSLSGFKMMEMFGLVEKDFSAVDGVSMEPGTFNLYPCYRLHKDALVSQPTKYLHPEGLPSDYTISFLFRILHDTPQEPFALWEILNKDSDPLVGVILDNAGKTLTYFNYDYRGEFQTITFDGPEIKKVFYGSFHKLHIVISKTLAKVIIDCQQVGEKPINASGNITSDGIEVLGRMVRSRGLQDSSAPFQLQMFDIVCATSWANRDRCCELPALRDEENCPALPHSCSCSENGKGPLGPAGPPGGPGLRGPKGQRGDQGPVGPDGPRGQAGSPGPQGPPGPQGPSGLSIQGSPGMPGEKGEKGEHGLPGQQGIPGGSGSPGRDGTQGQRGWPGKDGSNGPPGPPGPIGVPGAPGMPGVTGSIGPQGGLGLPGLPGAKGERGERGDLQSQAMVRAVARQVCEQLIQSHMARYSSLLNQIPSPSESGRAVPGPPGEPGRQGSPGPPGEQGPPGPPGFPGNQGTPGTPGERGLSGDKGERGNPGATSQGPRGPPGPAGPPGESRTGSPGPSGSPGSRGPTGHVGAPGPQGRPGPPGYCDPSSCGSYGTGGECESPRWGGGR
The following text describes a protein:
Function:
Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
Subcellular Localization:
Mitochondrion.
Sequence:
MWGVSSRRWAASARRARVSGFAASFSSTSDVKDAKVVAQAKKWQQQQPEDKAKFLSIQVDRSALKQPGDALPSQSPVDLPQNKSKENSLVHVLRSMIEVKGPLTVAEFMTRALSHPDHGYYMKKDVFGSQGDFTTAPEISQMFGELIAVWCVATWQQMGTPSHVKIVEMGPGRGSLMSDFLRAAKSFPPFYEAIEIHMVDISPAMQKIQQETLKCEPVEDKTAPENTMRLPDNGPTVRWHADFANVPHGPSLMIAQELFDALPAHQFEYTDRGWCERLVDADYEDSGDHFRFVLSPGPTPATRVYIGREKLFDPTQALSHVAETHISGVEDLKKMQGAVVQRLDVADVAGTPVRTAQAQVGDKIEISPVSIALVQDMAKRISQSGGGALIVDYGYDHPSELSLRGIKNHEFVSVLREPGDVDLSIDVDFATLRRFATAESKVTISGPVGQGTFLKNMGIEHRLAMLLQNTESEKVQEDLFSSFERLVEPEQMGTIFKAMALTHTDIGQPVGFEDTPSETTET
The following text describes a protein:
Function:
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.
Sequence:
MAVELPQLVVRGANGLSLLKWKTDGTSEENISFFRICDQKCRTTKFSNDGKLFAWCDMKQVHIMEMGSGNILSSINQPRTFAMYFSPDAKLLCTWEQYAVTKDTPAGTPNFNIWNVSDGSCVHNSIQKKVNGWRPDWLPGTTICGKLTGQSVQFYEDNDFKTAKHRLSIEKLEVFEVSPNIKPPHRVACFVRGARGGPASVKIFQYPKFTTGDVVANKSFFKADTVSIKWNKRGTELLVTAAVDVDTTGESYYGEQSLHFMSCTGETSIVQLSKKGPIYDSAWSPLSNQFCVVFGFMPAKACLFSNKCNKTFEFGSTPKNECYYNPHGNLLILAGFGNLRGNIEVWDCCRHSQVSQFTAPDTTCLEWCGDGCHFVTATTSPRLRVNNGYKLWHYEEWLLFVYTINFQNELNDVQWRPVPTGTYTAPLVKLVTSKNLSNMISASKPASYVPPHARGWSYNVTNFKLDEDEPIIQEPLSKSAQKNKKKREGKKNKTPTNSSLSSEQQDVIQMAKYLLNDEAAQPTQPTQLAGEDKKIKSLRKKLQAVEKLKKQQSEGKQLEKNQIEKLNTEDSIIEELKKLGVSV
The following text describes a protein:
Function:
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization.
Miscellaneous:
MISCELLANEOUS: Required to transform actin polymerization into active movement for the propulsive force of Listeria monocytogenes.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cell projection, lamellipodium. Note=Targeted to the leading edge of lamellipodia and the distal tip of stress fibers through interaction with a number of proteins. In activated T-cells, localizes to the F-actin collar and the distal tip of microspikes.
Domain:
The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization.
Sequence:
MSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASSTFRVVGVKLQDQQVVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNSQEGGPSTQRQVQNGPSPEEMDIQRRQVMEQQHRQESLERRISATGPILPPGHPSSAASTTLSCSGPPPPPPPPVPPPPTGSTPPPPPPLPAGGAQGTNHDESSASGLAAALAGAKLRRVQRPEDASGGSSPSGTSKSDANRASSGGGGGGLMEEMNKLLAKRRKAASQTDKPADRKEDESQTEDPSTSPSPGTRATSQPPNSSEAGRKPWERSNSVEKPVSSLLSRTPSVAKSPEAKSPLQSQPHSRVKPAGSVNDVGLDALDLDRMKQEILEEVVRELHKVKEEIIDAIRQELSGISTT
The following text describes a protein:
Function:
Involved in the immune response to bacterial infection.
Subcellular Localization:
Secreted.
Sequence:
MSHKIAAVCLLMSCLIATAYSAAKVPISIYYESLCPDSAKFITEQVYPAVKGELRDVVELTFVPFGKSQFVTQGSEVTFTCHHGPNECYGNKVHACAIEHIQANSYQVEYTRESLTMDFINCLMKAGKNFPDNVYPGQRCASENHINNWENIKTCANSTEGSVLLRKAGESTMRLKEPLTSVPTILFNEQFDKKVNDRAQVNLVGTICQYVSAPQPRICNQHNGASTPSLASVSAILSSLLGLWFIRSFY
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MYLSLLLLPMFGSAVTGLLGRKIGVTGAHIITCSCLITSAILAIVAFYEVGLCNSSVSINLISWIDSELMDVSWGFMFDSLTVSMLLPVLVVSSLVHIFSVDYMSADPHNQRFFAYLSMFTFFMLVLVTGDNYLIMFVGWEGIGISSYLLINFWFTRIQANKSAIKALVVNRVGDMFLSIGFFAIFFVFGNLDYSTVFSIAPFINETIITIIGLLLLLAAMGKSAQLGLHTWLPDPSMEGPTPVSALIHAATLVTAGVYLLLRSSPVIEYGPTTLIVITWVGALTAFFAASTGLLQNDLKRVIAYSTCSQMGYLFMACGLSQYNVALFHLVNHAFFKALLFLAAGAVLHATYDQQDQRRLGGLIGFLPFTYTAILIGSLSLIALPWLTGFYSKDLILEVAYGQYEFSGQVAYWLGTLSACLTAFYSLRLISLTFLTYPNASKSVYLHTHDAPTIVMIPLIILSLLAIFFGYVARDLFVGMGSDFLSPSLFTHPSHITLIEAEFGLPQIIKLLPAIGTLLGAGLALYLYHMLPVFTIDLTNSTLGQKLYRFFNGKYYVDVIYNHYIIYGGLQLGYVISKVLDRGIIELVGPYGLATGLTSGSKDIAKLDTGNLTSYALYLAIALVTLIMILLSPVLLNAALINAPLILVLLVAMVCIPYINSSSNDTVTTVQVKL
The following text describes a protein:
Function:
Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid. Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE) which serves as precursor for N-acylethanolamines (NAEs) (By similarity). Required for complete organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light. Organelle membrane degradation is probably catalyzed by the phospholipase activity (By similarity).
Subcellular Localization:
Membrane; Single-pass membrane protein. Cytoplasm, cytosol. Mitochondrion membrane; Single-pass membrane protein. Lysosome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Note=During eye lens differentiation, recruited from the cytosol to various organelles, including mitochondria, endoplasmic reticulum and lysosomes, immediately before organelle degradation. This translocation is triggered by organelle membrane damage and requires the C-terminal transmembrane domain.
Domain:
The C-terminal transmembrane domain is required for the targeting of the protein to damaged organelles.
Sequence:
MDNQQRRTDNMASGETDHLQCVEEPQPGDLIEIFRPAYQHWALYLGDGYIINLTPVDEGQATAVSSVKSVFSRKAVVRMQLLKEVVGADSYRINNKYDDDHTPLPVSEIIQRAQMLIGQEVSYDLLGSNCEHFVTLLRYGEGVSEQASRAIGAISLVTAAASAFSVLGLINTRSRNRPF
The following text describes a protein:
Function:
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites. The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DNA double-strand breaks (DSBs). Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of babam2 and help the 'Lys-63'-linked deubiquitinase activity mediated by brcc3/brcc36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Domain:
The VWFA-like region is similar to the VWFA domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes.
Sequence:
METTEPGQADGEERMMDLRPRTRSNPEGAEDRRSSTGSLNSSLPSAPQPAVGSRVEGEGEAASSDSPPVSATAIAATASVPVAAVGNTTTTNTASLPAMSPAVKERPKPSQPTMPTQIPPSAELHLRAPRVNCPEKVIICLDLSEEMSLQKLESINGSKTNALNISQKMIEMFVRTKHKIDKRHEFALVVVNDDAMWLSGFTSDPRELCSCLYDLETNVCESFNLEDLFNVILQKIELPQMENIQTIPPPFVVRTLLVFSRHAGMLQFNPSDAVKKMLQSPYFFFDVVFLHNGTEEQTEDTSWKDVYASFCELDTKGMCYRFEVSLCGPAIELHNCMAKLLCHPLQRPFQSHASYSLLEDEDTLENEATV
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MEELFQYTETQKHQTITKSRKKRLTENQVRLLESNFSSNNKLEPDRKCQLAAELGVPPRQVSIWYQNKRARDKAQSLEIDHGNLQLRLESVLADNARLKGQVAMLKDELNRIQSAFVTPFNNIDVVDHKHDLEGWLINDSLVGGGAPFVAPPGMDMVSDLVRR
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MSFMRAGNIACSRVGRLVTYRNTRMLSATAFRAETSVKPSSSVADAPTTPLSESTLIQKETPAEAMTRHQPDYDATVDHGTSKFSPVPKRVMDGSEPGETVPAAVLSGAPTDLQARTVRIFRPSKPATQSGEWHSHHWRMDWDILQKGHRWENPLMGWQSSADAMQGTHLNFKTKEDAILFAQKQGYEYFVQEPNERKFVPKAYANNFVHEPKKLKHIRTK
The following text describes a protein:
Function:
Required for anther development and early tapetal function during microspore maturation. Regulates callose dissolution required for microspores release from the tetrads.
Subcellular Localization:
Nucleus.
Sequence:
MGRPPCCDKSNVKKGLWTEEEDAKILAYVAIHGVGNWSLIPKKAGLNRCGKSCRLRWTNYLRPDLKHDSFSTQEEELIIECHRAIGSRWSSIARKLPGRTDNDVKNHWNTKLKKKLMKMGIDPVTHKPVSQLLAEFRNISGHGNASFKTEPSNNSILTQSNSAWEMMRNTTTNHESYYTNSPMMFTNSSEYQTTPFHFYSHPNHLLNGTTSSCSSSSSSTSITQPNQVPQTPVTNFYWSDFLLSDPVPQVVGSSATSDLTFTQNEHHFNIEAEYISQNIDSKASGTCHSASSFVDEILDKDQEMLSQFPQLLNDFDY
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MAALPPDSWQPPSVYLETSMGIILSELYWKHAPKTCYYSGTKFHRIIEDFMIQKGDPTGTGRGGAFIYGKQFEDELHPDLKFTGPGILAMANAGPDTNGSQFFVTLAPTQWINSKHTIFGQVCQGIGMVNRVGMVETNSQDRPVNAVKIIKAYPSGYALLLS
The following text describes a protein:
Function:
Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp) (By similarity). Represses gene expression at transcription level, probably by regulating histone deacetylation and epigenetic regulatory network.
Subcellular Localization:
Nucleus.
Sequence:
MAEQELQRINEKKPWQVLEFYSGIGGMRYSLMASGIVSEVVEAFEINDSANDVYQHNFKHRPYQGNIQSLTAADLDKYNADAWLLSPPCQPYTRQGLQKHSGDARAFSFLRILELIPHTTKPPQMLFVENVVGFETSDTHMEMIGTLTKLDYVTQEFILSPLQFGVPYSRPRYFCLAKRKPLPFKSQHSNNKLLWSPDPLYGRDDQVEFGKCQAEEGLDKLLEFCKPVEKFLELAAHVDGEPSSVDDSENGSKDCCGQEGDSVPDSVHQYLVPVSLIERWGNAMDIVYPDSKRCCCFTKSYYRYVKGTGSLLATVQPKIKGKESCLKEQRLRYFTPREVANFHSFPEDFEFPKHISLRQRYAMLGNSLSVAVVAPLLRYLFDS
The following text describes a protein:
Function:
May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MAGLGFWGHPAGPLLLLLLLVLPPRALPEGPLVFVALVFRHGDRAPLASYPMDPHKEVASTLWPRGLGQLTTEGVRQQLELGRFLRSRYEAFLSPEYRREEVYIRSTDFDRTLESAQANLAGLFPEAAPGSPEARWRPIPVHTVPVAEDKLLRFPMRSCPRYHELLREATEAAEYQEALEGWTGFLSRLENFTGLSLVGEPLRRAWKVLDTLMCQQAHGLPLPAWASPDVLRTLAQISALDIGAHVGPPRAAEKAQLTGGILLNAILANFSRVQRLGLPLKMVMYSAHDSTLLALQGALGLYDGHTPPYAACLGFEFRKHLGNPAKDGGNVTVSLFYRNDSAHLPLPLSLPGCPAPCPLGRFYQLTAPARPPAHGVSCHGPYEAAIPPAPVVPLLAGAVAVLVALSLGLGLLAWRPGCLRALGGPV