The following text describes a protein:
Function:
Involved in the organization of desmosome cell-cell junctions. Of particular importance in cell adhesion in the skin and during cardiac development. May also play a role in the regulation of Wnt, TGF-beta and Hippo signaling pathways.
Subcellular Localization:
Cell junction, desmosome. Cell junction, hemidesmosome. Cell projection, podosome. Cytoplasm, cytoskeleton.
Sequence:
MPANPSGTVFPTLVVLGHVATLIAVWRWMQRRKQISEDERDRVQKKTFTKWVNKHLVKAQRHITDLYEDLRDGHNLISLLEVLSGETLPRERDVVRNSRLPREKGRMRFHKLQNVQIALDFLKHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVNGQSDDMTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHKHRPNLIDINKVYRQTNLENLEQAFSIAERDLGVTRLLDPEDVDVPHPDEKSIITYVSSMYDVMPRVPDVRDGVKANELELRWQEYYELVTMLLQWIRHHVIVFEERKFPSSYEEIEVLWRQFLKFKETELPAKETDKNRSKLIYKSFEGAVQAGQVKVPPNYHPIDVEKEWGRLHVAILEREKLLRSEFERLERLQRIVSKVQMESGVCEEQLNQVETLLQTDIRLLSAGKPIQHASDIETDLNKAENMIRYLFNDVQLLKDGRHLQAEQMYRRVYRLHERLVNLRSEFNLRLKSGVTLSQVPMTQVPMTQISHVQTLQQSPQRVRPDLDEVTLKYIQDLLSWVEENQRRIEGAEWGEDLPSVESQLGSHRGLHQSIEEFKYKIDRARADENQLTPVSKGAYREYLGKLDLQYAKLLTSSKTRLRSLDQLHAFVVAATKELMWLNEKEEEEVNYDWSDRNSNMTAKKDNYSGLMRDLEQREKRVNNVQMTGDKLLKDGHPARKTIEAFTAALQTQWSWILQLCCCIETHLKENTAYFQFFSDVKEAEDRMKKMEDTMKKKYVCDRSITVTRLEDLLQDAVEEKEQLNEFKTHLEGLNRRAKTIIQLKPRNPAQPIKGKLPVQAVCDFKQMEITVHKGDECALVNNSQPYKWKVRDSSGNEAVVPSICFIVPPTNKEAVDVSSGLDGSQQRLMVLWQKLHVDMKSLLSWQYLMRDITLINSWNFIMFKTLRVEEYRLTLKNLEQHYQAFLRDSQDSGLFGADDRMQAENSYNKATQHYDNLLRSVEQEPALIQKDSTSGEQDESVCKSYITQIKDLRLRLEGCESRTVNRLRQMVDKEPLKACTQRATEQKKVQTELEGIKKDLDKVVEKSEAVLATSQQSSSAPVLRSEIDITQKKMEHVYGLSSVYLDKLKTIDLVIRSTQGAEDILNKYENQLREVNKVPVNEKEIEASQTQLQKLRSEAEGKQATFDRLEEELQRATEVNKRMSQLHSERDVELEHYRQLVGNLRERWQAVFAQIELRQRELDLLNRQMQAYRESYDWLIRWIADAKQRQDKLHAVPIGGSKGLQEQLTQEKKLLEEIEKNKDKVEDCQKFAKGYIDAIKDYELQLVTYKALVEPIASPLKKAKMESASDDIIQEYVTLRTRYSELMTLSSQYIKFIIETQRRLQDEEKAAEKLKEEERKKMAEMQAELEKQKQLAETHAKAIAKAEQEANELKTKMKDEVSKRQDVAVDSEKQKHNIQRELQELKTLSEQEIKAKSQQVEEALLSRTRIEEEIHIIRLQLETTMKQKNTAETELLQLRAKAVDADKLRNAAQEEAEKLRKQVAEETQKKRKAEEELKRKSEAEKDAAKEKKKALEDLEKFKLQAEEAERHLKQAELEKQRQIQVVEEVAKKTAATQLESKQVALTARLEESLKNEQVMVIQLQEEAEHLKKQQAEADKAREQAEKELETWRQKANEALRLRLQAEEEANKKTAAQEEAEKQKEEAKREAKKRAKAEEAALKQKEAAEMELGNQRKMAEETAKQKLAAEQELIRLRADFEHAEQQRTVLDDELQRLKNDVNSAVKQKKELEEELIKVRKEMEILLQQKSKAEKETMSNTEKSKQLLESEAAKMRELAEEATKLRSVAEEAKKQRQIAEEEAARQRAEAEKILKEKLTAINEATRLKTEAEIALKEKEAENDRLKRKAEEEGYQRKVLEDQAAQHKQAIEEKIGQLKKSSDTELDRQKKIVEETLKQRKVVEEEIHILKLNFEKASSGKQELELELKKLKGIADETQKSKAKAEEEAEKFRKLALEEEKKRKEAEAKVKQIQAAEEEAARQHKAAQEEVGRLMKLAEEAKKQKEIAEKEAEKQVILVQEAAQKCSAAEQKAQNVLVQQNKDSMAQDKLKEEFEKAKKLAQEAEKAKDNAEKEAALLHKKAEEAERQKKAAEAEAAKQAKAQEDAEKLRKEAEKEASRRAEAEAAALKLKQEADSEMAKYKKLAEKTLKQKSSVEEELVKVKVQLDETDKQKSVLDVELKRLKQEVSDAIKQKAQVEDELSKVKIQMEDLLKLKLKIEKENQELMKKDKDNTKKLLEEEAENMKKLAEEAARLNIEAQEAARLRQIAESDLAKQRELAEKMLEEKKQAIQEAAKLKAEAEKLQKQKDQAQVEAQKLLEAKKEMQQRLDQETEGFQKSLEAERKRQLEITAEAEKLKVKVTQLSDAQSKAEEEAKKFKKQADEIKIRLQETEKHTSEKHTVVEKLEVQRLQSKQEADGLHKAIADLEKEKEKLKKEAADLQKQSKEMANVQQEQLQQEKTILQQSFFAEKETLLKKEKAIEEEKKKLEKQFEDEVKKAEALKAEQERQRKLMEEERKKLQSAMDAAIKKQKEAEEEMNGKQKEMQDLEKKRIEQEKLLAEENKNLREKLQQLQSSQKASYTKEIEIQTDKVPEEELVQMTMVETTKKVLNGSTEVDGVKKDVPLAFDGIREKVPASRLHEIGVLSKKEYDKLKKGKTTVQELSKNDKVKMCLKGKDCIGGVIVEPNQKMSIYQALKDKMITQSTAIMLLEAQAASGYIIDPIKNRRLSVSESVKDGLIGPELHTKLLSAERAVTGFKDPFTGDTISVFEAMKKGLITEDQAIKLLDCQYATGGIIDPVNSHHVPVQLACTQGQLDEDLSKILSSPPADKKAFIDPNTKDSLTYSELLDQCKPDAETGIPLLPITEQAAQSERTYSDEETKDVFSKANLTVPFGRFKGKTVTIWEVINSEYFTEDQRKDLIRQYKTGKITVEKIIRIVITVVEDKENKKEPAFDGLRSSVPASELLEAKVINKDLFNKLHNGKATLKDVSELEPVKKALKGTHSIAGVQIESTSEKMSLYDAMKKNLLGTEPALNLLEAQAGTGFIIDPVKNQKLTVDEAVKSGVVGPELHEKLLSAERAVCGYKDPYTGKTVSLFEAMQKDLIKKEQGVRLLEAQLATGGIIDPEKSYRITPDIAYKRGHLNEEMNQNLSKPSDLSTVYVDPNTQEKVTYTELLKRCITDKQTGLPLIPLSEKAIKSKDIEPVSDAQTKENLSHATVELHSGLFKGRVITIWEIINSEYFTEEQRIEFIRQYRSGKITIEKLIKIVISTVDEKEKKRQDNFDGLRGPVPASSLLESKIIDKDTYDKILQGKKKPAEVSGSVKQYLQGSDCIAGVFFQKTKEKLSIYQAMKQKLLTSDTGMSLLEAQAATGYIIDPIRNEMFTVDDAVKAGIVGPEVHEKLLSAEKAVTGYKDPYTGNKISLLQAMQKQLVLREHAIPLLDAQVATGGIIDPVNSHRLPNDVAIERGYFSKQLAKSFKDPTDDIKGFTDPNKDENVTYKQLKERCMTDPEFGVALLPLSKAQTHEEAEKSYVYTEEQAQTDLANTQIDIPHERFAGKQVTLWEVMKSDMLPEEEKQRLLEQYRSGKITKERMVIIIIEIIEQREIIKTEQSMSCDVIRRRVTIDELYRARIIDLETYNLLKQGKKAIREVMEMPSVKQYLFGTGSISGVLSDNYAKVSIYQAMKRGLIKPDIGIDLLEAQAATGFMIDPVKDELLTVDEAVRKGLVGPEFHDKLLSAERAVTGYKDPYSGKVISLFQAMKKDLVPEDYAMKLLEAQVATGGLMDPEYYFRLPIDIAMQRGYMNKETSERISDPSGDVNQFIDPTTDEKVSYASLLKRCKVDKESGLRLLSLADKRLLFKGLRKQITPEELLRSQIIDQKTYTGLMEGTISVEDLSKDLKKYLEGISSIAGVFVEATKDRLSVYQAMKKTMIRPGTAFELLEAQAATGYIIDPIKNLKMNVQEAVKMGVVGPEFKDKLLSAERAVTGYKDPYSGKVISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEMAYKRGLFDEEMNGILTDPSDDTKGFFDPNTEENLTYLQLMERCMTDTETGLSLLLLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYIELAEQECEWEEITTSSSDGVVKSMIIDRRSGRQYDIDDAISKGLIDQSALDQYRAGTLSITEFADMLSGNMSGFRSRSSSFGSSSSYPMSPVPSIKTPATTWTDPTEETGPVAGILDTDTLEKVSVTEAMHRNLVDNITGQRLLEAQACTGGIIDPNTGEKFSVADAQNKGLVDKIMVDRINLAQKAYQGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDVTGRVSLDEAVRKGSLDARTAQKLRDVSGYSKYLTCPKTKLKISYKDAIDRSMIEEGSGLRLLEASSQSSKGLYSPYSISGSGSTSGSRSGSRTGSRSGSRRGSFDATGSGFSMGFSSSYSPTSYGRRYDSGVHGGHQMDELKQALTALASGRNCCYDEKRIFTSSHTQTSLVA