lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
Subcellular Localization:
Cytoplasm.
Sequence:
MTEDFPKILPLLVEEDTFLYPFMIAPIFLQNNASIKAVAYAKNNKSLVFIACQKDKLNDNEAPYYDVGVIGSVMREANMPNGRVKLLFNGIAKGRILEPAKENEQGFLEAQISPIEYLEYDKENIQAIVEVLKEKVITLANVSSLFPPDLIKALEDNDDPNRIADLIAAALHLKKDQAYSLFANNNTEQRLLDLIDIVIEETKTQKLQKEIKSKVHQKMEQTNKEYFLKEQLKQIQKELGTDKQRDEDLNQYYQKLESIKPFLKEEAFKEIKKQIDRLSRTHADSSDSATLQNYIETMLDVPFGQYGKKALDIKHVREQLDKDHYSLKRPKERIVEYFATMQLLEMRRKKKPEKKDKTKGTILCFYGPPGVGKTSLANSIAKAIERPLVRIALGGLEDVNELRGHRRTYIGSMPGRIVQGLIEAKKMNPVMVLDEIDKVDRSVRGDPASALLEILDPEQNTAFRDHYANFSIDLSQVIFIATANNIDRIPAPLRDRMEFISVSSYTPNEKEEIAKNYLIPQELEKHALKPSEVEISHECLKLIIEKYTREAGVRDLRRQIATIMRKVALKYLEDNPHQKGRTKKGKNEKSEDQKSEDQKSENQKSENKDFCVSITPNNLKEYLERMVFEIDPIDEENKIGIVNGLAWTPVGGDVLKIEVLKIRGKGELKLTGSLGDVMKESAIIAFSVVKVLLDNETLKVPKIPSETDAEGKKKKKVLKVYNAYDLHLHVPEGATPKDGPSAGIAMASVMASILCDRATRSEVAMTGELTLSGEVLPIGGLKEKLIAAFKAGIKTALIPVKNYERDLDEIPAEVRENLNIVAVKNIAEVLEKTLL
The following text describes a protein:
Function:
Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding.
Subcellular Localization:
Cell membrane. Cytoplasmic vesicle, secretory vesicle, Cortical granule.
Sequence:
EEGAGGRVWTLVLRNHCAFVPASGPGFIVGAPSASHCAGACETRFSEDLTPEETQTSWDKDIPAINQGLIPEESPESSFLLEGDILRPSPFRLFSATSSKWPKNGGVVEVPFLLSSKYDKPSRQVILEAFAEFERFTCIRFVAYDGQRDFISIIPMSGCFSSIGRSGGMQVVSLGPSCLQRGPGIVLHELMHVLGFWHEHSRADRDHYIRVNWNEILPGFEMNFIKSRSSNMLVPYDYSSVMHYGRLAFSRRGLPTITPLWAPSVHIGQRWNLSNSDIARVLRFYDCSPSGHEPSGKGE
The following text describes a protein:
Function:
Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C). Can also hydrolyze N(4)-acetyl-2'-deoxycytidine and N(4)-acetylcytosine with lower efficiency. Has weaker activity towards a wide range of structurally different N(4)-acylated cytosines and cytidines.
Sequence:
MQPNDITFFQRFQDDILAGRKTITIRDESESHFKTGDVLRVGRFEDDGYFCTIEVTATSTVTLDTLTEKHAEQENMTLTELKKVIADIYPGQTQFYVIEFKCL
The following text describes a protein:
Function:
Most highly expressed siglec (sialic acid-binding immunoglobulin-like lectin) on B-cells that plays a role in various aspects of B-cell biology including differentiation, antigen presentation, and trafficking to bone marrow. Binds to alpha 2,6-linked sialic acid residues of surface molecules such as CD22 itself, CD45 and IgM in a cis configuration. Can also bind to ligands on other cells as an adhesion molecule in a trans configuration. Acts as an inhibitory coreceptor on the surface of B-cells and inhibits B-cell receptor induced signaling, characterized by inhibition of the calcium mobilization and cellular activation. Mechanistically, the immunoreceptor tyrosine-based inhibitory motif domain is phosphorylated by the Src kinase LYN, which in turn leads to the recruitment of the protein tyrosine phosphatase 1/PTPN6, leading to the negative regulation of BCR signaling. If this negative signaling from is of sufficient strength, apoptosis of the B-cell can be induced.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
SWGQGLWLSLLWLHQLKWKFILPQEVWAWRGTCVWIPCSYTAPRGHTTNSLTWLHKPRFNDTLKEFEGLVLYKWGWGQGTPPGTRLRGHGWGSQDQGNCSLILEDVQEADGGQYGLRLVGVPNFKWFEKVQVNITVHSPSLPPSLPPSLPPPPGWLTTQREWDRSSPPPALCTPGPWGPPSPSPTLPPYSPPPSPSLITALSAAATVFLNVQRECLEVICLTLSAGSNVTLKCLVGSSHPPPWHFSWLRDEGKVLGSTGDTLTLVHVGKDDNGAYSCRAQNNLGENESEKVQLQIPLPQTVVAEGSTVTLTCETVANPAVFQYQWYHDGQTVLQEMNRTLTLKDLRPHHSGLYTCSGQNSLGWGGSQKGAQLDVQYPPVGVEVRPQKANPIREGDAVTLACSYNRSNPPVSSYAWDVGSLPHTSSSEGVLYIFRVPWNPEPVTCTVSNPRGSTSSQPLHLDVQYAPQNVRVVLDPPQPHVRAGDRVRLRCEFSSSRPSEVSYGWSRGERALAAGENLDFAAIEPEEAGRYTCSVTNTAGSSRSQELHLVVHYPPRRLRVSISPDDTVIERTAVALTCEADANPGVFRYSWFDERGQELPYSGRKLTLAAARAGHSGAYWCQGTNGLGTGQSPPSTLTVYYSPQTIAKRAAMGICASLAVFVLSVLGVRLVQVGAGWTAGVIFQSRGPRRPEAPRSLGCSNPGLEDTISYATLRFPTGSSLPGDCVTYSVLQIPPGDDYENVTGPSAPPPPDEGLHYSELLQFRGGPRPPAQDHVEYAALRH
The following text describes a protein:
Function:
Catalyzes the hydrolysis of beta-1,3-xylan into oligosaccharides, mainly xylotriose and xylobiose with smaller amounts of xylotetraose, xylose, xylopentaose and xylohexaose. Does not hydrolyze xylobiose, p-nitrophenyl-beta-xyloside, beta-1,4-xylan, carboxymethylcellulose, curdlan, glucomannan or beta-1,4-mannan.
Domain:
The carbohydrate binding module (CBM) binds to insoluble beta-1,3-xylan, but not to insoluble beta-1,4-xylan, beta-1,4-glucan, beta-1,4-mannan, curdlan, chitin, or soluble polysaccharides.
Sequence:
MKKLAKMISIATLGACAFSAHALDGKLVPNEGVLVSVGQDVDSVNDYSSAMSTTPAGVTNYVGIVNLDGLASNADAGAGRNNVVELANLYPTSALIVGVSMNGQIQNVAQGQYNANIDTLIQTLGELDRPVYLRWAYEVDGPWNGHNTEDLKQSFRNVYQRIRELGYGDNISMIWQVASYCPTAPGQLSSWWPGDDVVDWVGLSYFAPQDCNWDRVNEAAQWARSHNKPLFINESSPQRYQLADRTYSSDPAKGTNRQSKTEQQIWSEWFAPYFQFMEDNKDILKGFTYINADWDSQWRWAAPYNEGYWGDSRVQVLPYIKQQWQDTLENPKFINHSSDLFAKLGYVADGGDNGGDNGGDNGGDNGGDNGGDNGGTEPPENCQDDFNFNYVSDQEIEVYHVDKGWSAGWNYVCLNDYCLPGNKSNGAFRKTFNAVLGQDYKLTFKVEDRYGQGQQILDRNITFTTQVCN
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLNIQTHMDFEGQGRAEKLSRIIITLFGTVGLVWGYIIQQFSQTVYILIAGVLLASILTIPPWPIYRKKPLNWQKPRPDSQTAQSAGDETKKKKKN
The following text describes a protein:
Function:
Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Subcellular Localization:
Cytoplasm.
Sequence:
MKLAVYVHVPFCKSKCVYCDFYSVVSEKFDEYFSHLLREIDLYEEVLSESEIKTVYFGGGTPSVVPPSFLKMVLEKLERVSRGFTPDEITIEVNPESVETEKLKIYKQIGINRISLGVQACDDTVLKNAGRLYKEETLKKKAKIVLEQFENVNFDFILGLPGETDITLKKDFRFLEEFPPQHVSLYLLEVDERTRLFDLIQKGLVELPEEDDVERRHDLFVEFLKERGFLRYEISNFAKPGKKSLHNLFYWRNENYLGLGVSAGGHIGRFRYVNASDLKEYEEKITKGELPYEYVHENTEEEEALETVFMGLRIKEGVELNRVKILLPLLEKLQKKYPCYLKVKNGKIFLSEDGMNFSKKILSDLIEWYREGGR
The following text describes a protein:
Function:
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrium between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
Subcellular Localization:
Cytoplasm.
Sequence:
MSRNEVLLNGDINFKEVRCVGDNGEVYGIISSKEALHIAQNLGLDLVLISASAKPPVCKVMDYNKFRYQNEKKIKEAKKKQKQIEIKEIKLSTQIAQNDINYKVKHAREFIESNKHVKFKVVLKGRESQNSKAGLDVLFRVQTMMQDLANPEKEPKTEGRFVSWMFVPKAKEAPKNEKKTKENNPPFNRINLMKGENHAKNED
The following text describes a protein:
Function:
Multidrug resistance transporter involved in resistance to azole antifungal drugs such as the imidazoles miconazole, ketoconazole, and tioconazole; as well as the triazoles itraconazole and fluconazole. Also plays a role in the resistance to other antifungal drug families such as the polyene amphotericin B, the pyrimide analog flucytosine, the fungicide mancozeb, and the polyamine spermine. Decreases the intracellular accumulation of clotrimazole by mediating its extrusion from cells. Involved in virulence by conferring resistance to the human antimicrobial peptide histatin-5.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVEEISPKYTNEQAEASSSSSSSVSGEPKDFSGSLENQEDLGELIERTNTMTSGAESKVETNRRMSRILTGTQDDPEKIAIDYSNCPPMGGDRPFPPALPEQSQFEVTFDGPNDPIHPFNWSMKTKTIICIVLCLNCICISMGSSIFASGVPQICKIYHVIPVVAILGVTLYVFGFAASPVIYAPLSEVYGRRGVLVISAFGFAVFQFAVATSKDLQSIMICRFFGGLIGAAPMAVVPAAFADMFDVRVRGKAICLFSLGVFVGPILSPVMGSYIAQRTTWRWLEYVTGCFASALFVAVALTFKETHHPTILVQKAKEMRKSTNNWGIHAAHEHVELSVSEIAKKTITRPIKMLFTEPLLLIITIYNSFVYGILYLMLEAYPIVFVEGYGFEANGELPYIALIIGMLVCTAFLWYFENDYLKRIQKAGKLVPEARLIPMVYAGVIFPIGILWFCWTGYYPHKIHWMCPTVAGSFIGFGLMGIFLPCLNYIIESYLPLAASAVAANTFMRSAFGAVFPLFAGYMFHGMGTGWAGLLLGLFAAALIPVPLFFLKYGERIRKNSKDAYYA
The following text describes a protein:
Function:
Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing. Participates in tight junction development by regulating apico-basal polarity, a key step in tissue development and organization. Mechanistically, regulates the translocation of PAR6-aPKC from the cytoplasm to the apical surface by acting as an adapter between PARD6B AND CRB3. Also acts as a negative regulator of mTORC1 under nutrient-rich conditions by binding to the active Rag GTPases to inhibit mTORC1 localization to the lysosome and phosphorylation of downstream targets. This facilitates constitutive basal autophagy during nutrient availability (By similarity).
Subcellular Localization:
Cytoplasm. Lysosome. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear.
Sequence:
MAFPEPKPRAPELPQKRMKTLDCSQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWDVATGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDCRSRKPEPVQTLDEARDGISSVKVSDHEILAGSVDGRVRRYDLRMGQVSSDYVGSPITCTCFSRDGQCTLISSLDSTLRLLDKDTGELLGEYVGHKNQQYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSNVVQSLAYHPTEPCLLTAMGGSIQYWREETYEAEGGAG
The following text describes a protein:
Function:
Bifunctional oxidoreductase probably ables to act both on prenyl naphthoquinones and on prenyl benzoquinones. Catalyzes the penultimate step in the biosynthesis of vitamin K1.
Sequence:
MTDARPRICILGGGFGGLYTALRLGQLSWEGHTPPEIVLVDQRDRFLFAPFLYELVTEEMQTWEIAPPFVELLAESGVIFRQAEVTAIDFDHQKVLLNDQDKGTESLAFDQLVIALGGQTPLPNLPGLKDYGLGFRTLEDAYKLKQKLKSLEQADAEKIRIAIVGGGYSGVELAAKLGDRLGERGRIRIIERGKEILAMSPEFNRQQAQASLSAKGIWVDTETTVTAITATDVTLQFREQEDVIPVDLVLWTVGTTVSPLIRNLALPHNDQGQLRTNAQLQVEGKTNIFALGDGAEGRDASGQLIPTTAQGAFQQTDYCAWNIWANLTGRPLLPCRYQPLGEMLALGTDGAVLSGLGIKLSGPAALLARRLVYLYRFPTWQHQLTVGLNWLTRPLGDWLKNEPS
The following text describes a protein:
Function:
Transcription factor probably involved in vascular development and shoot tissue organization. Binds to the DNA sequence 5'-CCGAGTGTGCCCCTGG-3' present in the promoter region Box II of the phloem-specific rice tungro bacilliform virus (RTBV) promoter. May regulate tissue-specific expression of the RTBV promoter and virus replication.
Subcellular Localization:
Nucleus.
Sequence:
MPSKSLIPPPTTPNPNLPCPNAPVVPPSMCGGGGDLDPAPHFGGPHHRRAHSELAFRISEDLHLGPASEDDVFRTYMDVEKIGSGMEDGEAPASEAAEHSGPRDRSAVDCLSGNEGNAAARPKHRHSNSVDASSSRGEGVFGDVMEAKKAMPPEKLAELAVIDPKRAKRILANRQSAARSKQRKANYIVELERKVQTLQTEATTLSAQLTLFQKDISELATENAGLKLWLQSMEQQAQLNDGVNDGLKQEVERLKIATGEKVERSEAYNLGLMNLPFLPFVMPSQEQPRNHQRGFEFQAQIQQSQLDNNSVPSNMMQQGHLMVLPGVDIRKGSEILNPDNSITASEGSCNS
The following text describes a protein:
Function:
Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea and/or loss of appetite. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future (By similarity). Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (By similarity). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions. The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues (By similarity). Required for avoidance behavior in response to food allergens: induced downstream of mast cell activation to promote aversion and minimize harmful effects of exposure to noxious substances (By similarity). In addition to suppress appetite, also promotes weight loss by enhancing energy expenditure in muscle: acts by increasing calcium futile cycling in muscle (By similarity). Contributes to the effect of metformin, an anti-diabetic drug, on appetite reduction and weight loss: produced in the kidney in response to metformin treatment, thereby activating the GDF15-GFRAL response, leading to reduced appetite and weight (By similarity). Produced in response to anticancer drugs, such as camptothecin or cisplatin, promoting nausea and contributing to malnutrition (By similarity). Overproduced in many cancers, promoting anorexia in cancer (cachexia) (By similarity). Responsible for the risk of nausea during pregnancy: high levels of GDF15 during pregnancy, mostly originating from embryos, are associated with increased nausea (By similarity). Maternal sensitivity to nausea is probably determined by pre-pregnancy exposure to GDF15, females with naturally high level of GDF15 being less susceptible to nausea than females with low levels of GDF15 before pregnancy (By similarity). Promotes metabolic adaptation in response to systemic inflammation caused by bacterial and viral infections in order to promote tissue tolerance and prevent tissue damage (By similarity). Inhibits growth hormone signaling on hepatocytes (By similarity).
Subcellular Localization:
Secreted. Note=Secreted in the plasma.
Sequence:
MPGQELKTLNGSQMLLVLLVLLWPPHGGAVSLAEASRASFPGPSDLHSEDSRFRELRKRYEDLLTRLRANQSWEDSNTDLIQAPEVRILTPEVRLGSGGHLHLRISRAVLPEGLPEACRIHRALFRLSPTASRSRDVTRPLRRQLRLARPQAPALHLRLSPPPSQSDQLLVKSSSSRPQLALHLRPRASRGRRRARARNGDRCPLGPGRCCRLHTVHASLEDLGWADWVLSPREVQVTMCIGACPSQFREANMHAQIKMNLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDLLAKDCHCV
The following text describes a protein:
Function:
May stimulate membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment.
Sequence:
MSNQGKDSFKAYSYFCPCGQLFLTIHVSLTRLPQRQLDKRHVVDEKLNHIAHFSTGNKYYITRSDGGYEQRIQLLCRRCTLECAYALEAAPGYIYVDPTLVNEKPVTVSVSNLKE
The following text describes a protein:
Function:
Acts as a quorum sensing protein regulating discoidin gene expression during growth and development. D.discoideum is a single-celled amoebae and switches to multicellular development when food becomes limited. As the growing cells reach a high density, they begin expressing discoidin genes. The ability of psiF/dicA to induce discoidin gene expression when present in conditioned medium, suggests that it allows cells to sense their local density.
Miscellaneous:
MISCELLANEOUS: According to PubMed:15947191, it is secreted in the conditioned medium. However, prediction tools clearly predict a transmembrane domain. In some conditions, it may be cleaved and secreted in the conditioned medium, which would explain the discrepancy.
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Secreted.
Sequence:
MKYLFIAIILILYCSFTKADQKKFLVNMYDNDPLFSPDFENANGAQTGLVKKKLGSDGKPIPANYDMKDPNGNYYIKNATTFKSWFNEVAGVSILVPFELVLTQTAGSQNYYSYSNTSFFPLNELGWYNPSIKGDYEFKKYQDSNKKEQNFHFCMHASFIMSTNCKEVFKFKGDDDVWVFINDVLVLDIGGVHGVQDGTVDMANLPEKIHDSTNSKLGNCKNGTYPFDFFYCERHTKASNCLFETNMGFTCSYYDYCGICNGKGECCTDVKLNQCYTKKCPLPNSLPNGATNYQDYMTIVPTNTCGGTDKCKIYSCNNSTGCEFKQKSCDDGDKCTKDACDSKTGYCSNIPTNPSVVTSCLKSGCDSTTGNYSTPTNCDDKDPCTIDSCINGQGCVHTKACDDEDPCTTDSCSADGKCTHTAIAKCNSDCPSCPSKKCKITSCSEDSGACNYVDMVFASPSECYKATCDPETEEAIYSPIDSSCDTSDSCFTAQCNLNKTCTRVPAINCDDNNECTTDSCSGGSCSNTAIACDDNDPCTIDTCSPSEGCIFTPIVCEQTSLCNTFTCSVGKCVPTPITCSSSVKCQDSICREGVGCVYFNRTCPPDDDCSSAYCSMETGKCISKAYDPLPFSCQSTAVKVGVGIGAAAAAGIAIGGAVAAGLAIFGGKKAYDTWKTSRGNVMTGSQSNPLYTQNQNNGNNPLYSAPAE
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MSVVLCCTHGRLEIDLFLEDAPRTCRNFLELCKAGYYDGITFHVISLVLSSPALVSDYNLLAGTGRGGYSIYGARFDDEISARHNHDATGIVSMANFGRNTNASQFFILFKPSPHLDGKHTVFGKVRENSLVVLDKMQLVKVKKNNVPVEPVKL
The following text describes a protein:
Function:
Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle. Secreted.
Sequence:
MMMAGMKIQLVCVILLAFSSWTLCSDSEEEMKALEADLLTNMHTSKISKASVPSWKMSLLNVCSLINNLNSQAEETGEFHEEELMTRRKFPTALDGFSLEAMLTIYQLRKICHSRAFQHWELIQEDVLDAGNDKNEKEEVIKRKIPYILKRQLYENKPRRPYILKRGSYYY
The following text describes a protein:
Function:
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway (By similarity).
Subcellular Localization:
Cytoplasm. Cell projection, lamellipodium.
Sequence:
MENRDDEVEHQHSTMGSEGGTAGDGTPPPKRKGKFSTLGKIFKPWKWRKKKSSEKFKETSEVLERKMSMRRPRQELIEQGVLKELPDNESGEAHGHKAPYVKNGHTLPVGVGGSLALEQVHSPSESEFRINPVWLPQPEDRRARAPSDGDHRGALGPRASNQDDGRRGGWSVGTEDWKNNLAWHGEDIRRGGRAHAEMDKRPGLMKAPSEDGRRTRPEPDWKPTLPRHSSVEEGRGRRESDSSQYLPNSEMMRDTLREPLPPKQSIMPPKWLMTSTPEPGSDSLPRTPVHNPAAPSFCSSNSSSSSSAGKPLRNVSSAGANTAPPGGAPLTTSSAPCSMGTIPNHPSKQPPMPPPKPINRSNNPAIMAELTQGGMNLVPAKPSPPMPPKRTTPVTKRNPEDSPLTIASLPSILSEDMRANIPGGYQLPPPPPSPPLPTHIPPSPPRAHTHHLLHQHSYPYPLPQPLPVHFDPPSPPEDPPARDEDDYSDEEEEEEDDEDDEEPPPDHLPSPQSQPELEPRSRRCLVGELSVSVIPEGNNSSEEEEDEEDQHPEESDSDGPVLYKDDESDEDEEDDSPPSALASRVKRKDTLALKLSSRPSAPDRQAPERQAKSEHSGLSWQSKEQWEAIRTQIGTALTRRLSQRPTAEELEQRNILQPKNEADRQAEVREIKRRLTRKLSQRPTVAELQARKILRFHEYVEVTSAQDYDRRADKPWTKLTPADKAAIRKELNEFKSSEMEVHEESRIYTRFHRP
The following text describes a protein:
Function:
AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.
Subcellular Localization:
Nucleus.
Sequence:
MSQGLPAAGSVLQRSVAAPGNQPQPQPQQQSPEDDDRKVRRREKNRVAAQRSRKKQTQKADKLHEEYESLEQENTMLRREIGKLTEELKHLTEALKEHEKMCPLLLCPMNFVPVPPRPDPVAGCLPR
The following text describes a protein:
Function:
Required for normal zoospore movement, formation of appressoria by germinated zoospore cysts and plant infection.
Subcellular Localization:
Nucleus.
Sequence:
MNLSRFAPSPSSDSLISTLRPRAAVRRLHSNITGPMTPFKTAVNAYVASEGTDNSYVVRPRLYNDKRAQSDGSNALLSSIGPSGTTKRPRDEMDCFTDTHKHKRGDGNKSRRREQCRANQARYRDKQRNAQQQLERSVEQLQSELSTLKHRNLDLASRQRTNQSPWNTVAEVFRLLGVCFRSPWRVTCVQEMRNHSEMRQILAILERSFTHDVAMGDLRGIDALMEQLLQFSQY
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as a non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells; Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSPTLIFLLAMSLFAVNNGNPNIEIKIGVILDMDSNVGKMSKTCISMAIADFYRKHDNYTTIIDPYYRDSKQDNVQAASAALDLMKNIQVTAIIGPMTSSQADFVIDLGNKLKVPVISPAASPSLSPTNNVYFIRSAHDSTLQLKPITELIKHFRWSEVVFMYEDGEYGRGLVPYLSDAMMNIGTKVTYQTVIYPSVSDDWILAELYKLKTMQTRVFVVHALPDLASRLFKKVNEVGMMDEGYVWIITEGLTNQLHYLDHKEDLMQGVIGVNSYIPNSGELFDFKRRWKREFRSRYPEDDVTELDMSGIRLYDTVFGLAMALEKIQKEKGDSDGTGALNMRTRLLSSIRNFRFDGISGDFNMINGQLQSSVYEIVNIIGSGENTIGFWSPEIDGISKKLSNNTKGLKPVTWPGGSHVIPKGWEIPVSNKNMLRVGVRVGGFDQFIDEHIDPETGQITMTGFCVDVFNAVVDELPYAFKFEFVPFVTSDGKKPAGSYDDLVFNLSAGGNDAVAGDITILAHRSDRVAFTLPYTEAGVSLVVPIKDERKSAWIFLKPLEKELWITTGAFFIYTGIVVWVIEHRVNEEFRGAPHKQVGMLLWFSFSTLVYAHREKLISNLSRFVVIVWVFVVLVLTSSYTASLTSMLTVQKLRPTYTDINEIKRNGESIGYQDGSFVRDMLIRMGFNDTQLKGYSTFEQYHDALELGSQNGGVSAIMEELPYIRVFVAKYCNMYTMRGPIHKTAGFGFAFPVGSPLVHDVSKAILQVTEKQMMNITNHWFKEDANCDQQLKGPQMKTEGFGLNSFKGVFLIAGLSSTSALLIFVLRFLYQNREMLVSQDHSVSQKLLVMVETFDVLRDNKSKTTIPKGAVHVESHNNNSPAISVFHQEAEVFSQDEEFSSTQPGSPLVLDTIQVVQTTTN
The following text describes a protein:
Function:
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Sequence:
MTDTYNSISNFIENELTALLSSDDYLMDDLAGELPNEVCRLLKAQVIEKRKDAMSRGKQDLLSKEIYDNESELRASQSQQIMELVGDIPKYSLGSELRNRVEGEPQSTSIERLIEDVLKLPQMEVADEEEVEVENDLKVLSEYSNLRKDLILKCQALQIGESKLSDILSQTNSINSLTTSIKEASEDDDISEYFATYNGKLVVALEEMKLLLEEAVKTFGNSPEKREKIKKILSELKK
The following text describes a protein:
Function:
Mitochondrial metal transporter involved in mitochondrial iron accumulation.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MLRISIDSIKQFGSFVPGYNNTSYHAAGRAIRTSSLYSTMISANPRRCLHSSKLLNKEGQEEGYNEQLISKMSSQNGSNSRQNESEGKKEGKASSVKSLLQHTHSHSHTHMHDNPLLSLNVQQIKKNPGVRITWIGLASNVGMAVGKFVGGITFHSQALLADSVHALSDLVSDFLTLFSVQYASRKPTSEYPYGYGKVETVGSLAVSTILAMAGISIGWSSLCAIVGPVIPHAILESMAGLIGETHSHSQSLTQQATNVNAVWIAAGSILVKEWVFQATKKVAIQTNSNVLMANAWHHRVDSLTSLVALVAITSSYFFNIQSLDNLGGLVVSGLIIKTGGQGILSSLKELVDQSIPPTDPRYLEIESVIKDSIGSLKTDLDLKQSLHVRDLTILASGPNLRATTTLEVPVLHSGQEVGIRFLENAISTIREDLRMKVPNVGKVDVEFVDVTSDSKGDLEHSHDTKSTNHTHTHSDSADTHTHKH