lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
G protein-coupled receptor (GPCR) that plays a role in diverse physiological processes particularly within the immune and nervous systems. Becomes active when triggered by various endogenous ligands including endocannabinoid N-arachidonyl glycine (NAGly), delta-9-tetrahydrocannabinol or resolvin D2/RvD2 derived from the omega-3 fatty acid docosahexaenoic acid (DHA). Upon RvD2 binding, facilitates the resolution of inflammation, aiding in tissue repair and homeostasis. Mechanistically, RvD2 ligation initiates Galphas protein coupling, activation of cAMP-PKA signaling pathway and phosphorylation of STAT3, leading to RvD2-stimulated macrophage phagocytosis. Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (By similarity). Activation by N-arachidonoyl glycine (NAGly) can also induce apoptosis in macrophages. Plays a role in homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs) in small intestine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant. Also participates in hypotensive responses, mediating reduction in intraocular and blood pressure.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane.
Sequence:
MATLSNHNQLDLSNGSHPEEYKIAALVFYSCIFLIGLFVNVTALWVFSCTTKKRTTVTIYMMNVALLDLVFILSLPFRMFYYAKGEWPFGEYFCHILGALVVFYPSLALWLLAFISADRYMAIVQPKYAKELKNTGKAVLACGGVWVMTLTTTVPLLLLYEDPDKASSPATCLKISDITHLKAVNVLNFTRLIFFFLIPLFIMIGCYVVIIHSLLRGQTSKLKPKVKEKSIRIIMTLLLQVLVCFVPFHICFAVLMLQGQENSYSPWGAFTTFLMNLSTCLDVVLYYIVSKQFQARVISVMLYRNYLRSVRRKSVRSGSLRSLSNMNSEML
The following text describes a protein:
Function:
Transcription factor involved in iron utilization and virulence.
Sequence:
MLDRLNRKQSKERFVNKIPISTTKIDKSLEHTRRDDESNNAKRGVNPDESYSSDTSFTPTVVSGTEDAALTRTSTNRQRQGKSSFKSFFRTMSLKVNSKTRNKDRKTKEELAAEKALAELRNLPRNPLDLELNELHVASNFNEVRKIIDDIFIDENHDAASKAIRISTQNKSFSAMEKPYSLTKIKSLQTEDDYSLPITSFIIETLEENSIHADLSHNDNAITSTDILIEEEEEMEQEEEEEMLNYDDLDVISDKIDEVGAESSISTSNDRGIIANATANGPIIVGDSTESVDTSNIENRKLVVVNSTPDDHDYYATNDMNDNFITPNPSNESVETLAGVYKDFEVTNATEANTEAGKTTDINAETSNAIDAVADTENKVTAEDDATDTVNTGESMTDTTTSTTDNKNDKEVDKEVENAVDSNVTTNDTIPDKAANIDNESSSDNSIDATTANTTNTNNFNDAEVNTEATNTIVDNVTNDKFNSVDVSTTTPTATTVSGIPTADEMTNNVNTNRISTATVDSFTGKTGENYESFITNAGKDSNDNNADLKTPTNNSATTTTNTQSGVSNKKSNSKTGSSEQNPFQKKLMNYLNSLN
The following text describes a protein:
Function:
Involved in osteoblast cell differentiation. May play a role in inducing the cell cycle arrest (By similarity).
Subcellular Localization:
Nucleus envelope. Cell membrane; Single-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Note=Colocalizes with NELL1 on the nuclear envelope and the perinuclear region.
Sequence:
MTANVTVSSMYLFTVLLLLFNVYVNSQDTDAQLCQMCEGTIRHDSPVWSFCITKGYVKGHCCFKNNTSDVDTIIGLDLSNCSISHVEHLYNSSTALIIDLSNNPISNLSDYVFQGFSQLTQLLLPSKLECPGGRASWEKVEVKSITRICEGQKNACNQTVQMPLVCPENSLCSPYGPGFFECSCLNNFHGYKCMRQGEFPLVKVLGILTASTVVVSSVLWFTQRRKVKNT
The following text describes a protein:
Function:
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
Subcellular Localization:
Cell membrane. Cytoplasmic vesicle.
Sequence:
MMGSLPSRGKNSSPSSSSSFSGPGQEPVSIQAERQKVSAVALGSFPAGEQARLSLRVGEPLTIISEDGDWWTVQSEVSGREYHIPSVYVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSIRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCALREPCVLQKLGPLPGKDTPLPVTVPTSSLNWKKLDRSLLCLDAPASGEASLLSEGLRESLSSYISLTEETALDDA
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus.
Sequence:
MSRRVSAAVPTRVVGKTARLSNVGPAYGIPGISNGGKSGLLQRRASFHGGKSSQPRTDPRPLNDRAFQQECIRSLTGYLLTHGYNVPISTKLLVSPASKDVLNIVQFLFQKVDPNLKLSGKVEEDVPVVFKRLGYPFQISKSALYAAGSPHTWPGLLAALVWLIQLLLHQEATESVETFDDAGARSFLENLSQSYQCFLAGDDDECERLDYAFRQQFEDCTAEVMEKVAKLRVPEVEEQLQKLSTEVSPLTSLESKKADFLSDKQKFNTIISSLQWHKQAAEKKLQERKEDLLAKKAEKNEIQADIEELRNRIASQEINLADIERMQKEKDLLDANIQPIVAKDQQLRKAAWEHELATTNKEKDLEILCGEHNDRCQRLKPILADGQPLSGAQLQITLQLDRTLPQEILGTSVSGGLKQTILEVMESCKRYTNQEREEAITCEKEVYACEAARQEKLDLLSRNVATIKKLEALYKASKEKWDAAYVAVVNEREELEAKVIAKEVAAKRTDADAEELVKQWEQRYEAGTASCADQLASAKKQWIEVVDYILSAKEQITMLLQNLKTKTHVEAGKVKRDLSELVSTMAALQV
The following text describes a protein:
Function:
Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
Subcellular Localization:
Cell inner membrane; Single-pass type II membrane protein.
Sequence:
MAFSTGGNRGPMADINVTPLVDVMLVLLIIFIVTAPIMTYPIAVDLPQRVLNPPPQTTEPPPPIELRIDASNQVFWNNSPTPVAQLQQKMEEVVQADPTNQPELRIDANEDAEYEVMAKVLAAAKNSQMKKIGFMQ
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQNYSEHCKLNETVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
The following text describes a protein:
Function:
May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MATRGLLLASWALLGALVLQAEARPAPYGVKLCGREFIRAVIFTCGGSRWRRADILAHDPLGEFFADGEANTDHLASELDEAVGSSEWLALTKSPQVFYGGRSSWQGSPGVVRGSRDVLAGLSSSCCEWGCSKSQISSLC
The following text describes a protein:
Function:
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Membrane raft; Single-pass type I membrane protein.
Domain:
The VWFA domain (or beta I domain) contains three cation-binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent MIDAS site (ADMIDAS). This domain is also part of the ligand-binding site.
Sequence:
MLPQRPQLLLLAGLLSLQSVLSQECTKYKVSTCRDCIESGPGCAWCQKLNFTGQGEPDSTRCDTRAQLLSKGCPADDIMEPKSLAETRQSQAGKQKQLSPEEVTLYLRPGQAAAFNVTFQRAKGYPIDLYYLMDLSYSMVDDLANVKKLGGDLLRALNDITESGRIGFGSFVDKTVLPFVNTHPEKLRNPCPNKEKECQPPFAFRHVLKLTDNSKQFETEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKSSNEFDYPSVGQLAHKLAESNIQPIFAVTKKMVKTYEKLTEIIPKSAVGELSEDSKNVVELIKSAYNKLSSRVFLDHNTLPDTLKVAYDSFCSNGVSQVDQPRGDCDGVQINVPITFQVKVTATECIQEQSFTIRALGFTDTVTVRVLPQCECQCREASRDRSVCGGRGSMECGVCRCDAGYIGKNCECQTHGRSSQELEGSCRKDNSSIICSGLGDCICGQCVCHTSDVPNKKIYGQFCECDNVNCERYDGQVCGGDKRGLCFCGTCRCNDQHEGSACQCLKSTQGCLNLDGVECSGRGRCRCNVCQCDPGYQPPLCIDCPGCPVPCAGFAPCTECLKFDKGPFAKNCSAACGQTKLLSSPVPGGRKCKERDSEGCWMTYTLVQRDGRNRYDVHVDDMLECVKGPNIAAIVGGTVGGVVLVGILLLAIWKALTHLSDLREYHRFEKEKLKSQWNNDNPLFKSATTTVMNPKFAES
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell; In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
Subcellular Localization:
Nucleus.
Sequence:
MVNVLKGVLIECDPAMKQFLLYLDESNALGKKFIIQDIDDTHVFVIAELVNVLQERDALVYNCKQ
The following text describes a protein:
Function:
Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF-binding leads to autophosphorylation and activation of the RET receptor.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus, trans-Golgi network. Endosome. Endosome, multivesicular body. Note=Localizes mainly to the plasma membrane. In the presence of SORL1, shifts to vesicular structures, including trans-Golgi network, endosomes and multivesicular bodies.
Sequence:
MFLATLYFALPLLDLLMSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNFSLTSGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSPYEPVNSRLSDIFRAVPFISDVFQQVEHISKGNNCLDAAKACNLDDTCKKYRSAYITPCTTSMSNEVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCSYEERERPNCLSLQDSCKTNYICRSRLADFFTNCQPESRSVSNCLKENYADCLLAYSGLIGTVMTPNYVDSSSLSVAPWCDCSNSGNDLEDCLKFLNFFKDNTCLKNAIQAFGNGSDVTMWQPAPPVQTTTATTTTAFRVKNKPLGPAGSENEIPTHVLPPCANLQAQKLKSNVSGSTHLCLSDSDFGKDGLAGASSHITTKSMAAPPSCSLSSLPVLMLTALAALLSVSLAETS
The following text describes a protein:
Function:
Plays a central role in centrosome maturation and mitotic spindle assembly during the first division of the zygote. Required for the centrosomal localization of air-1 and zyg-9. Probably not required in late embryogenesis and during larval development.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Component of the centrosome. First expressed at two different foci in early postmeiotic one-cell stage embryos, prior to pronuclear migration but after the sperm-donated centriole duplication. These two foci greatly increase in size prior to and during mitosis. In metaphase, it is localized throughout centrosomes. In late anaphase or telophase, it surrounds a central core devoid of microtubules. Its localization is independent of microtubules and other centrosomal proteins. Recruitment to the centrosome during prophase of the 1-cell embryo is regulated by the cye-1/cdk-2 complex.
Sequence:
MEDNSVLNEDSNLEHVEGQPRRSMSQPVLNVEGDKRTSSTSATQQQVLSGAFSSADVRSIPIIQTWEENKALKTKITILRGELQMYQRRYSEAKEASQKRVKEVMDDYVDLKLGQENVQEKMEQYKLMEEDLLAMQSRIETSEDNFARQMKEFEAQKHAMEERIKELELSATDANNTTVGSFRGTLDDILKKNDPDFTLTSGYEERKINDLEAKLLSEIDKVAELEDHIQQLRQELDDQSARLADSENVRAQLEAATGQGILGAAGNAMVPNSTFMIGNGRESQTRDQLNYIDDLETKLADAKKENDKARQALVEYMNKCSKLEHEIRTMVKNSTFDSSSMLLGGQTSDELKIQIGKVNGELNVLRAENRELRIRCDQLTGGDGNLSISLGQSRLMAGIATNDVDSIGQGNETGGTSMRILPRESQLDDLEESKLPLMDTSSAVRNQQQFASMWEDFESVKDSLQNNHNDTLEGSFNSSMPPPGRDATQSFLSQKSFKNSPIVMQKPKSLHLHLKSHQSEGAGEQIQNNSFSTKTASPHVSQSHIPILHDMQQILDSSAMFLEGQHDVAVNVEQMQEKMSQIREALARLFERLKSSAALFEEILERMGSSDPNADKIKKMKLAFETSINDKLNVSAILEAAEKDLHNMSLNFSILEKSIVSQAAEASRRFTIAPDAEDVASSSLLNASYSPLFKFTSNSDIVEKLQNEVSELKNELEMARTRDMRSPLNGSSGRLSDVQINTNRMFEDLEVSEATLQKAKEENSTLKSQFAELEANLHQVNSKLGEVRCELNEALARVDGEQETRVKAENALEEARQLISSLKHEENELKKTITDMGMRLNEAKKSDEFLKSELSTALEEEKKSQNLADELSEELNGWRMRTKEAENKVEHASSEKSEMLERIVHLETEMEKLSTSEIAADYCSTKMTERKKEIELAKYREDFENAAIVGLERISKEISELTKKTLKAKIIPSNISSIQLVCDELCRRLSREREQQHEYAKVMRDVNEKIEKLQLEKDALEHELKMMSSNNENVPPVGTSVSGMPTKTSNQKCAQPHYTSPTRQLLHESTMAVDAIVQKLKKTHNMSGMGPELKETIGNVINESRVLRDFLHQKLILFKGIDMSNWKNETVDQLITDLGQLHQDNLMLEEQIKKYKKELKLTKSAIPTLGVEFQDRIKTEIGKIATDMGGAVKEIRKK
The following text describes a protein:
Function:
Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
Sequence:
MTVKYNQNGELTMDGISLKTIAQSFGTPTIVYDELQIREQMRRYHRAFKDSGLKYNISYASKAFTCIQMVKLVAEEDLQLDVVSEGELYTALEAGFEPSRIHFHGNNKTKHEIRYALENNIGYFVIDSLEEIELIDRYANDTVQVVLRVNPGVEAHTHEFIQTGQEDSKFGLSIQYGLAKKAIDKVQQSKHLKLKGVHCHIGSQIEGTEAFIETAKIVLRWLKEQGIQVELLNLGGGFGIKYVEGDESFPIESGIKDITDAIKSEIKVLGIDAPEIGIEPGRSIVGEAGVTLYEVGTIKEIPEINKYVSIDGGMSDHIRTALYDAKYQALLVNRNEEADDSVTIAGKLCESGDIIIKDAKLPSSVKRGDYLAILSTGAYHYSMASNYNQMQKPSVFFLKDGKAREVIKRQSLRQLIINDTK
The following text describes a protein:
Function:
DNA-binding protein which is required for efficient transcription-coupled nucleotide excision repair (TC-NER). Acts as part of a TC-NER complex which assembles and interacts with RNA polymerase II (RNAPII) when it stalls at DNA lesions. TC-NER complex subunit UVSSA binds to the GTF2H1/p62 subunit of the TFIIH transcription factor complex, tethering TFIIH to the TC-NER complex. WHR1/STK19 then interacts with the XPD helicase subunit of TFIIH which guides TFIIH to DNA downstream of the stalled RNAPII, ensuring DNA repair. Directly interacts with RNAPII and also binds to downstream DNA. Promotes the timely removal of DNA damage-stalled RNAPII, allowing downstream NER factors to access DNA lesions. Required for monoubiquitination of UVSSA. Regulates repositioning and stabilization of UVSSA within the TC-NER complex. Stimulates ubiquitination of RNAPII complex member RBP1. Also binds to RNA and regulates the expression levels of many mRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MNRKRRLLASEAFGVKRRRAPGPVRADPLRTRAGSAREAIEELVKLFPRGLFEDALPPIALRSQVYSLVPDRTVADLQLKELQELGEIRIIQLGFDLDAHGIVFTEDYRTRVLKACDGRPCAGAVQKFLASVLPACGDLSFQQDQMTQTYGFRDPEITQLVNAGVLTVRDAGSWWLAVPGAGRFIKCFVKGRQAVLSMVRKAKYRELALSELLGRRAPLAVRLGLAYHVHDLIGAQLVDCVPTTSGTLLRLPDT
The following text describes a protein:
Function:
May act as an acrosome-nuclear docking protein in sperm.
Subcellular Localization:
Cytoplasm. Note=Subacrosomal region. Does not localize in nucleus (By similarity).
Sequence:
MAKPTFKRQCYIKRHLRPLYRKHSRCSSINLGHGNYSLYINRVLKEVVPNRGISSYSVDIMNILINDIFERIATEACQQMFLRKRCTLTPGDIQQAVHLLLPKKLATLAVTFGSKAVHRFIHS
The following text describes a protein:
Function:
May play a role in the reorganization of neuronal actin structure.
Sequence:
MKHSKICQMSWQPQYRCSKYRHVFGKPANKESCYDCVPITRSVQDNHFCAVNPIFIAVVTECAGGGAFLVIPIQQSGKLDPHHPKVCGHRGNVLDIKWNPFNDYVIASCSEDATVKIWDIPKHLLNKNLTNPSKELLGHTRRVGLIEWHPTASNIIFSTGYDYKIMIWNIDSDDPVIYSPVRTIECHKDVILSMSFNTDGSLLATSCKDRIIRVIDPRQGTIIQESNCKIHKASKVLFLGNMKMLLSSGTSRWNNRQVALWDQNDLSVPLQQEDLDGSSGLIFPFYDCDTNMLYIVGKGDGNIRYYEVCPQKPYFQYLNEYRSSLPQKGIGALPKRGVNVSTCEVFRFYKLVTIKSLIEPVSMIVPRRSESYQDDIYPMTAGTQPALTAHEWLSGINRDPVLISLKPGSTPAPYQVEETKEEPRFPIKEPKEVHELKMPTRTLWEIEYKTEIIREDRSNKKALEKHQDTKQAMSNGFDISESPPPKTENELLQMFYKQQEEIRRLREQINQRDVQIKQLELEIKNKRNSTASY
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). Regulates motility patterns of both 9+0 and 9+2 motile cilia through differential localization and recruitment of axonemal dynein components (By similarity). Required for motile cilium formation and movement. Involved in the establishment of left-right symmetry during embryogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Sequence:
MLYSQRSRPRHREVTGPQPHSVAVVAKFPSSRPRDFAILERRRHEEAREQILTFTKLNTTERVKNKWARVTDQKLLHNMVQREVYRTMEEYKMHLNERRERLSTLLEREEMAYIKEMEAMEETTLERQAKMRERVKSLREKREKERMDFIAEKRDQQFREQCEELRSLRSQIHLNEVCTERMAQIVLKEELNRQRKEEDTIFDQLWEQDRLAKEEQEEKKRQKRIELNQEIACLQKAASEAQKMQEKRLKEEESKLMAEEQRLIKLEEERNLKEKQQNKLQVKSMLEDSIRLKMKRLAREQQEELALDMKILEHVMQGYQDDTEEKRQRKMELRKEQQLYREYLAQQLEEEKRQEREMDKMIEAELEKSWAKKSEQMRKEKEARKRLMKDVMDTRRVQIQEKLERNAKLQEELAHDKELLESATEEHKQLETDRNARQMKVAQQYQRDLVSQVAYQQSQRQAEREEEQREFEAGLTAEKAYQNKLREILSRPYVGHENIHPLRRGRISSPKDWLPQ
The following text describes a protein:
Function:
The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein. It acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization. The carboxylated form binds strongly to apatite and calcium (By similarity); The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development.
Subcellular Localization:
Secreted.
Sequence:
YLDPGLGAPAPYPDPLEPKREVCELNPDCDELADHIGFQEAYRRFYGIA
The following text describes a protein:
Function:
Part of the homotypic fusion and vacuole protein sorting (HOPS) tethering complex involved in endo-lysosomal vesicle trafficking and lysosome biogenesis. The HOPS complex facilitates docking and fusion of lysosomes with late endosomes and several other types of vesicles. The HOPS complex is also involved in autophagy and crinophagy (the elimination of unused secretory granules through their fusion with lysosomes). The HOPS complex mediates autophagocitic flux, probably by binding autophagosome-associated Syx17/syntaxin 17, promoting assembly of the trans-SNARE complex and instigating autophagosome-lysosome fusion. Independent of Syx17/syntaxin 17, HOPS is involved in biosynthetic transport to lysosomes and lysosome-related organelles such as eye-pigment granules. Required for autophagocytosis-dependent remodeling of myofibrils and transverse-tubules (T-tubules) during metamorphosis.
Subcellular Localization:
Cytoplasm. Lysosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Late endosome. Lysosome.
Sequence:
MHQAYSVHSILKQGVQIESIAAYGNHVILGTRSGQLIMYSVDEETGVDMRMFNKNFSRKPITQMEVIASENLLFVLTDLQVQVCDIRRIESNFAFMHSAPDTKGCTLFTMDVDTPKSTTGRVATVIRVCCAIRRRLVFFFWKEDKLNSLELIIELSDVPRTLCWVGHAVCVGFKDEYVVYDISGKAPKKHNLFLTSSSISRDPCICLIRNNMLGISKDSYLVVVDPSQYKESDGINNSTDVRPAAMDSNSSLTPLLWSSPLLDLVWDEPFAVGRVNNAIEVRSLVGKDTLVQTIPELQKTKFLVHADKGTIFAAATSELWCIRMVEIPIQRQQLLQQKKFQLAIELTQISDEPAADRAQTIRQIHMLYAKELFTNKEFSAAMKEFEKAAIDPYDVIRLFPNLVPEPKPGTEDVTVPTSSTPALEDSDLENAYLALIEYLAWARQREVVKLRDTKSSSKSLLEIIDTTLLKCYLQTNDSLVAPLLRLNQCHLEESEKTLKKHNKISELIILYQMKGKHKEALKLLREQASIEGSVLQGRKRTIRYLQELGGDHLPLIFEFADWVLNDNPEEGLTIFTDELIEVESLPRAKVLDFFISKHKALVIPYLEHVITEWKDGNTLLHNVLLKQYREKVQRLLAQQEKGEEVPELIPMRAKLYKMLEESNDYSPDRLLEEFPTNILLEERALILGRLKKHDNVLSIYIHVLGDVAKATAYAEAHYKEDKHIFHTLIKCILIPPTQPLYDGVPLHPDFSQVNREVALEILNTHATRIDPFEIFEHLPDDMPMPQLEKYLEKSIRKMMADKHEMQMMCGFLEAESTRLENALEEQRNISFELNESSVCSECKKRFQTQSAFVRYPNGHIVHLSCHDRLARAAAQQ
The following text describes a protein:
Function:
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
Subcellular Localization:
Cytoplasm.
Sequence:
MSIIAKTVFIGLSGGVDSAVSALLLKKQYQEVIGVFMECWDETLNNDFYGHKKINNNKSGCSSFQDFQQAKKIANSLGIKLIKKNLIEAYWNKVFLPMIQSFKKGLTPNPDIWCNRFIKFGLLHDFCKQINPNSLFATGHYAKINMIENQPLLSIPKDTNKDQTYFLANVKKEQFQNVIFPLADLKKITVRNIARENNWEVADKKDSTGICFIGERHFSDFLKNYLPVKKGLIKDWKTKQTISEHDGVWFYTIGQRSGLNLGGLKQRHFVVAKDIETNELFVSCDKEELLKTTILLDQFNWLYTPKQLPSQVLVRIRHAQKPEIAKLKLLSDNKLEITFKNPVISVASGQFGVLYTLDQICLGAGLI
The following text describes a protein:
Function:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes with the spindle poles in mitotic cells. In interphase, localized at the centrosome and diffusely in the cytoplasm. Localizes to mitotic spindle microtubules (By similarity).
Sequence:
MEALEEKEAQVAAWLKKIFGDHPIPQYEVNAWTTEILYNLSERNRIRDRDVYLVTEDLKQKAKEYESEAKHLQDLLMESVNFSPASLSSTGSRYLNALVDSAVVLETKDTSLASFIPAVNDLTSDLFRTKSKNEEIKLELAKLEKNLTATLVLEKCLQEDLKKAELHLCTERARVDSRLQNMDFLKAKSEEFRSGIRTAEEQLSARGMDASLSHQSLVALSEKLAELKRQTMPLKKKLESYLDLMPNPSLAQVKIEEAKRELDTIEAELTKRVNMMEL
The following text describes a protein:
Function:
Involved in viguiepinol biosynthesis. Catalyzes the conversion of geranylgeranyl diphosphate (GGDP) into copalyl diphosphate (ent-CDP).
Sequence:
MNVTSFAALRAAAQDIVDEMIADPYGLTSPSVYETARMVVSAPWLEGHRQRVEFLLAQQHEDGTWGGPAAYGLLPTLSAVDALLSVAGTQDARRVAGAVESGLAALAGRFPRNVELPDTIAVELLVPWLIEQVDQRLSRMDDRGDLPGRLDLQADTGTLSGIRELLRQNTGIPEKTWHSLEALGAPAVRSGTVTPMGGAVGASPAATSAWLGDPPHTDAAKACLAYLHQTQARHGGPVSGITSISYFELAWVVTALSGSGLDVDIPAQVPDILRTALGANGLSAGPGLPADSDDTSAALHALDLLGKPESVDCLWEYDTGLYFTCFPKERTPSTSTNAHILVALADRRGQGDTRYDHAAERVGGWLVEQQQPDGRWMDKWHASPYYATACGAAAMARLDGPRTSAALDDAIRWVLDTQHADGSWGRWEGTGEETAYALQVLNHRAAPDRPALEAIRAGRAFLSGHVEDDRRNPPLWHDKDLYTPVRVIRAEILGTLAATQRLAEAEKEARA
The following text describes a protein:
Function:
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Subcellular Localization:
Cytoplasm.
Sequence:
MVVKIELSGGLEYDAKTTHFEIEIGNIKTMRDVIHKIKEIQTGLAPIFTEESVIPGIIVLINDADWELVGMLDSEVHDGDVISLISSIHGG