lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MPLLHASNLCAHLQNVARVGRPLTSIPHNKLNLQIALGLYREGFLSGVQRGDIYGPDAVYTETTPQNVASRRLWIELKYRQNQPVLNSLKLVSKPSRRMVLTTEELRQLQLGRKVKFVNPPKIGEVILIKTPGKDGNVIDLNEACRRFLGGEVILRAS
The following text describes a protein:
Function:
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
Subcellular Localization:
Secreted.
Sequence:
MLLKVTTLALVLCAITGSQADVRTDQAVSAFWDYVSQLQSSTKDTVDQIQQSDITKQLNVLIQDKMKSMNLYAGELQSQVIPFAKQIHDQLTQDSEKIREQIQQELEQLRVKISPYADEVHKQVNKNLEELQLKLTPYAEELKSQLEKNTNTISQQLRSVVQEMDSKIRDNAGNLQESLAPYSEKLQAQIDESVDQLRKQLNPYTDEVRDKIGHQVQKLRESLSPYAEEMQENLAKQIESMEFQMRKSVEQADTQLKQITEQLKAQLSPYADDLKEKLQVNARDAKQTLEPYLTELNQQMEQKIAEFKVSITPYGEALNKALVQRVEDMKLKFGKYTVTVQDQMEYLEKDIRDKFSDFINKGITETEN
The following text describes a protein:
Function:
HMG-CoA reductase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (By similarity). HMG1 catalyzes the reduction of hydroxymethylglutaryl-CoA (HMG-CoA) to mevalonate (By similarity). The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10 that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthase ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase HMG1 finally reduces HMG-CoA to produce mevalonate (Probable).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLSFLTEVTGAIAQTSARRPIQFMVVPALLASIAYLSIIDDYIPEHIKSSSGSSGISYYHPYTSSHYKSQPDLDKWTAIDKEHINDDIYTQANQISVIPLRFRRFQDVVPNVPNAIHISDNEQILIVPTDQIENSLDQLQEITNNGITWKARNNDKLAKYYDYIRYGLNKVQDAIQHAENFDILLIFVAYLGMWYALIKVFVDMRKIGSKFWLAFSTLTSSTFAFLLALLVSNKFLHTKVSLLSLSEGIPFLVSVIGFKHKVSIATIVANSSTASPEDVPHVVGKAVSSHCLSMLRDHLVVIGGLLSCAIYAHHLTGLRNFCILSSLILSFDLILVYTFFSAILGLKVEINRARRTEDLQNALEEEGISSLVAARVAEQSATIEHPNEHNFFKSNNSSIAYFKVIMSLGFFAFHAFWLGSSWLYSTTDGGESFSRFSFLSNIPTLSQDISQQIPIGRKGTVVTILPTIFFMPSGFMVQLEDFIYLVLSKFSSAIRDSIISKFLVFGFALSIVTNVYFLNAARYQVSATHKLIEKEISRPQDSSVTATTTTTATGTTSSGAATSKTIGNNKGLKSVQEIPDNEDESSDEELEIKAPVKVLPLEECVKVLKEGKVKTLSNDEVSSLVVGGKLPLYALEKQLADNKRAVIVRRKAIAKLANAPVLDTNRLPYAHYDYDRVFGACCENVIGYMPLPVGVAGPLIIDEKPYHIPMATTEGCLVASTMRGCKAINAGGGVETVLTRDGMTRGPCVRFPTLKRAGAAKLWIDSEQGQATIKKAFNSTSRFARLQHIQTALAGTSLFIRFRTTTGDAMGMNMISKGVEYSLKYMVEECGWDDMEIVSVSGNYCTDKKPAAINWIEGRGKSIVAAARIPADVVTKVLKSDVDALVELNISKNLVGSAMAGSVGGFNAHAANLVTAVYLACGQDPAQNVESSNCITLMEKDKETGDLNVSVSMPSIEVGTIGGGTILEPQGAMLDLLGVRGPHPTNPGANAQQLAKIVASAVLAAELSLCSALAAGHLVQSHMQHNRSKAPAAGATTTTTPAITDSKASNGSIASNGKDLKRLEEGSVTCIKS
The following text describes a protein:
Function:
Putative transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
METIVNNQNNGQQNTVPTQSFSSSVYMNYDFFDSQQLQQPQHQPQHYQQQDSFVSPNLDNNNPQIHVQSNNYNQNGFVGYNNSNNNNNNNQHMNNQYSNSFHNNNSSGFMAFQNNSSNFNNQNNNNSNNNNNNNNINSYDYNNSNNNNYNNNNNTHSNNSNNNNNNNNSNYWNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNNNNNNNNNNHHHHHHQQQSQPTSPYNNPIQHNPNDMKFNGQHNPFNGNQMVMDNNNNNNNNNNSNVFNSNSNSNVFNSNSGSFLQINNNNGSFSSYNNNNNNNNNNNSNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNNNNNQFSQSYDSTLGNNRFSSMMGQPIQQQQSPPQQQQQQSFIQSSPQAIPASNCNGNGSTSSSTSPLSPTLIGSAPGTPTSMLATTLFGFNLSSSPTSSPSSPVKKGKSQSALALSSSGGSGGSSGRKKPQKHDSMSSITNTNLKSTQASTLKESKRSNSSPNLKKQMQLQQLQQQQKLNENGTLIPPLPFASISENITNNNNNNNNNNNNNNNNNNNNNITNNPLSGSMEFPNSNNINQSSDSINGEFNIGQPESPKMYNSSPSPPPNATSTTKGGKKSKKSLHISTTQQSPSLNGSTGGSMLTPTMSGLSLSGGGSGGGFSPLISPTGTTSNKDLQSSPSPSPLLKSMSMGKLDLQDSIDSMSSPLSPNSSLSSSNGLLPPPPNSNNMNSSGGIPTPSTPTSPPPLTHHINIFSNLEFVKQLKDHLLPNDFKPEEHALERNLLRFQQFVKTLAEPLQRDVVTSMFELSVDAQLQYGSNLDNDNLSALMLFRRKILNFNLFRMMMLNDPNSFIPLPSPFPIQTTTISSNGTIVNPTNVNNNNINNNNNNNNNNNNNNNNNNNNNNNNNNNNTTTTTTTTTSANTVQSGTTSNSNLVFQQTSNSNTLSPSQQQQQQTQQQQSINGSSTGSLSDAQYQDLGIHLDTSSANSGCGINVSIGSSIGGGGGGSSLNGSNLNGSSSISGSISGGSSNGGGQFIMSPQFSLDGAYQQQQPSSYNINNEMELAEKDEDEIFNNNNKDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSSSINSNINNVNNCNINNNSNSNNGSINSPRPSTPTTLNSSGKRSKKIYRGDSFGAGNDISTGLMASSDQIIPPPQQQQHQQLVNNNNNNMNNSENNILLADSNKGLSVSLGSLPTNTPSSMEIEQQQQQQQQQQQQQQQQHLNQQQILHQQLHHHLSSSLGGAQFTNIQQQQQQQSGNIFYNSPYNSSQVYMNPYGTSITNTSLAGPSTTSSAMQHMITNMTSSNIIVNNQNNNNNDQNNNNNNNNNNNSTTNSNVNNNNNTTNTPSSPPQPNNCTPTQTSIITSNGVVVPSLQMRGTITNPPPVLPTPDTLVLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQETPHTPTSNSISSPRSSPVHQQSPSNTNTTTTSTTTIRHSAVTQLSFAGLHNQQVSPISPRSPRSPHGTSGDYNDGSQSPSSRRKNRFTDFQIKRMNDCFENLDKNNNGKFTSEEICQIATELGLTDQQVRVFFQNKRARSRPSPRGQPTNPLTSSTNNGNNSNLALQHLQQQHLQQVQQQQQQLLQLQQQQQQQQQQLHQQSANTTPQLNSMNPNSINYNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNIINNNITTINE
The following text describes a protein:
Function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Sequence:
MYVVKRDGRQEAVHFDKITARLKKLSYGLSSDHCDPVLVAQKVCAGVYKGVTTSQLDELAAETAAAMTANHPDYACLAARIVVSNLHKNTKKSFSETIKMMYNHVSERSGLKAPLIADDVYEIIMKNAACLDSEIIYDRDFDYDYFGFKTLERSYLLKVQGKVVERPQHMLMRVSVGIHKDDIDSVIRTYHLMSQRWFTHASPTLFNSGTPKPQLSSCFLVCMKDDSIEGIYDTLKECAVISKSAGGIGVSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGGKRKGAFAVYLEPWHADVFEFLDLRKNHGKEEHRARDLFYALWVPDLFMERVQNDGNWSLFCPNESPGLADCWGEKFEELYTRYEREGKAKKVVQAQQLWFEILKSQIETGTPYMLFKDTCNRKSNQQNLGTIKSSNLCTEIIEYTSPTETAVCNLASIALPRYVREKGVPVESHPSKLVGSRGSRNRYFDFDKLAEVTAIVTANLNKIIDVNYYPVESAKTSNLRHRPIGIGVQGLADTFILLGMPFDSPEAQQLNKDIFETIYYHALKASSELAAKEGPYETYNGSPVSKGIIQPDMWDVTPSDRWAWAALREMISKNGVRNSLLVAPMPTASTSQILGNNECFEPYTSNIYSRRVLSGEFVVVNKHLLHDLTEMGLWSPAIKNNIIYEDGSVQKIPEIPDDLKVIYRTVWEIKQRTLVDMAVDRGSYIDQSQSLNIHMDQPNFGKLTSLHFYAWSKGLKTGMYYLRSRAAADAIKFTVDTPILQEKPEVVDDVSTQKAQMVCSLTNREDCMACGS
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MADGPPRFFTKPEEYVGVNNHRRTLFLDMDETLVHCYFEKPTFFIDTNEDFFQFTLEDDPSVTYYAFRRPGLNEFLYQCAEHYDMRIFTAGEDLYARTLLRWLLPDNLIDESRWYTRDACVGDGYGRLIKNLSMLDGFQFEERATLILDDSAPDNVYPHQNALAIPRFAPQTGHTDEENYGRMQADRGLEMFGRMLCGEHFTRCDDVRVPIARFYALIRTYTRSSTAKSEM
The following text describes a protein:
Function:
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis.
Sequence:
MATIPSVVREITLVGEQIFDHTQVVRAEIDRFVERFERNERHREFDGILRASHALVESSETPVEGLFDMGKMEHMTQCVDDITKKLQTLVEPKYQKEHDVYLEKVKEDQKKYVDVCREQAMNKMRSMTAHR
The following text describes a protein:
Function:
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Sequence:
MDAHELGIILISRGMLKFGEFTLTSGKKSNIYVDLRPLPSFPEEFMKIATEMSKRMNGDFGICGVAVGGLPLATAVAIISRRPLIYVRKEKKEHGTESLLEGSLNMRSYVIIDDVATTGGSILNAARIVRNYGPDVKEAWVVVDRMQGAAESLKEEGIELKSLATLPDIVKLVLDSLPERERSYALKYLGEVGV
The following text describes a protein:
Function:
Might contribute to the loading of the ESCRT machinery.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MGDNLMDKVTAFGERLKIGGSEVSNKISAGVSSMSFKVKELFQGPNPTDKIVEDATTENLEEPDWDMNLEICDMINQETINSVELIRGIKKRIMMKQPRIQYLALVLLETCVKNCEKAFSEVAAERVLDEMVKLIDDPQTVVNNRNKALMLIEAWGESTSELRYLPVFEETYKSLKARGIRFPGRDNESLAPIFTPARSTPAPELNADLPQHVHEPAHIQYDVPVRSFTAEQTKEAFDIARNSIELLSTVLSSSPQHDALQDDLTTTLVQQCRQSQTTVQRIIETAGENEALLFEALNVNDELVKTLSKYEEMNKPSAPLTSHEPAMIPVAEEPDDSPIHGREESLVRKSSGVRGGFHGGGGSGDDMMDDLDEMIFGKKNGCDSSTNPDHDPKKEQSSSKNDDLIRF
The following text describes a protein:
Function:
Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYSLIEAQLLGGKLVNRVMASLRRIIQRSLGYFCALNGILDFNTDIGTGNLRRYRVLFMYRLLHNFAVISLTLKFLFDFTDHFKYIESSTLITVNFFTYFTLVFFALLSSMGSCYQWQNRILAVLKELKHQRDLSRHMGYRVPRSKQNSIDYLLFALTVLLILRLSIHLATFTLSARMGFNHPCNCFLPECMIFSMNYLLFAILAEITRCWWSLQSGLKMVLLNRQLSTVAFNLWEIERLHTRFQCLIDLTSEVCSIFRYVTLAYMARNLWSGIVAGYLLVRFVIGNGLQDVELVYLVFSFITCIQPLMLSLLVNSMTSTTGSLVEVTRDILKISHKKSVNLERSIEWLSLQLTWQHTHVTIFGVFRINRSLAFRSASLILVHVLYMVQSDYISITN
The following text describes a protein:
Function:
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.
Subcellular Localization:
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Sequence:
MNGVLLRHQQPGGLGRAPRKPMPRGASRLVAKEPLSVRLPKADFSFLKYLAWPLLLAVLGYGAYRGAEYILPYADRPIAKVSVEGDLSYISQRAVQQRISPYLAASFFTIDLAGMRGQLEQMPWIAHAEVRRVWPDQVVIRLDEQLPIARWGDEALLNNQGQAFTPKELANYEHLPRLHGPQRAQQQVMQQYQLLSQLLRPLGFSIARLEMSDRGGWALTTAQGVEIQIGRDHVVDKIRRFVSIYDKALKDQISNIARIDLRYPNGLAVAWREPVTPATVATASAVQ
The following text describes a protein:
Function:
Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Sequence:
MAAVAVLRNDSLQAFLQDRTPSASPDLGKHSPLALLAATCSRIGQPGAAAPPDFLQVPYDPALGSPSRLFHPWTADMPAHSPGALPPPHPSLGLTPQKTHLQPSFGAAHELPLTPPADPSYPYEFSPVKMLPSSMAALPASCAPAYVPYAAQAALPPGYSNLLPPPPPPPPPPTCRQLSPNPAPDDLPWWSIPQAGAGPGASGVPGSGLSGACAGAPHAPRFPASAAAAAAAAAALQRGLVLGPSDFAQYQSQIAALLQTKAPLAATARRCRRCRCPNCQAAGGAPEAEPGKKKQHVCHVPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKSFTRSDELQRHLRTHTGEKRFACPECGKRFMRSDHLAKHVKTHQNKKLKVAEAGVKREDARDL
The following text describes a protein:
Function:
Involved in the metabolism of all major classes of plastid RNAs. Required for efficient 3'-end processing of mRNAs and 3'-end maturation of rRNA transcripts, but is not sufficient to mediate their degradation. Mediates tRNA degradation. May function as a poly(A) mRNA 3'-5' degrading phosphorylase (By similarity).
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MLATPGALHHLLLLPPPPHTQLAFHHAVGGVPAALLPLPRPRRVAASASTSRRGGARRRAAGARVRASVGEEAPPVVTEEASTSGGPTKFSTKIPVGDRHILVETGHIGRQASASVMVTDGETIVYSSVCLADTPNDPSDFFPMSVHYQERLSAAGRTSGGFFKREGRAKDHEVLVCRLIDRPLRPTMPKGFYYETQILSWVFSYDGIHSPDSLAITAAGVAMALSEVPNKQTIAGVRVGMINDQFVVNPTTEQMDDSELDLVMAGTDSAILMIEGYCDFLTEEKLLQAVETGQGAIREICKAIDGLVQKCGKKKMFDAIDLPPPELYRHVEDISGDELVKALQIKEKILRRKALSALEEKVITILSEQGYVAKDESSGVSENLADVIEEEDEDEVIVDGEVDEGEVHIKPVSRKPPRQLFSEVDVKLVFKEVSSKFLRRRIVEGGKRSDGRSPCELRPINSQCGLLPRAHGSALFTRGETQALAVVTLGDYQMAQRIDNLVDTEESKSFYLQYTFPPSSVGEVGRIGAPNRREIGHGMLAERALEPILPPEEDFPYTIRVESTITESNGSSSMASVCGGCLALQDAGVPIKFPVAGIAMGLVLDTLEFGGDGKPLILSDITGAEDASGDMDFKVAGNENGISAFQMDIKVVGITLPIMEHALLQARDGRKHILNEMSKCSPPPAKVLSPYAPLIHVMKVKPNKVNLIIGSGGKTIKSIIEETGVDAIDTGDDGTVKITARDLSSLEKSKAIIANLTMVPKVGEIYRNCEIKTIAPYGAFVEIAPGREGLCHISELSSSWLAKAEDAFKVGDRIDVKLIEINDKGQLRLSSRALLPDANQESSSKQQAGGSTREKAPQKDNLVKMTTRRPRRKKQAEASTAENNATASPKDLASQGSEMGTE
The following text describes a protein:
Function:
Cohesin cofactor dispensable during the meiotic division but playing an important role in DNA repair by homologous recombination (HR) probably by helping SMC5/SMC6 complex. Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MASSDTELEEQLLQAGNKLVDPPSSVDDLLPILDHVENCLSRVEQSPTKSMQSALSPSLKALIADKLFRHSDADVKVAVASCISEITRITAPDAPYDDNQMKEIFQLLVSSFENLSDNSSRSYTKRTSILETVAKVRSCVVMLDLECDALILEMFQNFFKAVRDYHPENVFSSMETIMTLVLEESEDISLDLLTPILASVKKDNEEVLPVARKLAERVFETCAVKVKPYLMQAVKTLGISFDDYSEVVGSICQETSSAVEQNEAHATGKDTADKSKSVKSSVDEEAPEDNGRSKAIAFSEPVKPAIQSNGVAQMGENDSLPPPNSDQKQEDGHHADPSISMNASSNAEPDSLDTENAINIEHQPRQTTRRGRKFNSTKKSTEPSENTEPPDNSVIDDEMETEKLPEHKNHSEDVPSPSPEEDPPVEATGSPKNEKETGTKVSSPKTLDNESGNVAPLSPRGGLPDESYSKKAGGRLKKKESLTKEATPSADEVSEKVSEATSDLELKPTRHTGKKVPSEISTENKTPTVVDESKKESSDSEAKPLRRPAKKVDGSSKIGDGSSSKRPEDKKRRGQGKAIREKDETKSPAKADDKEMVSSPKSITKSTKDDHHLDETPKTNSKRKRTPGKENDSDYGENLVGSKIKVWWPKDRMFYDGVIDSFISSSKKHRVLYTDGDEEVLNLKKEKWEYIGGDSGSDGEQVADQPSPDPSSEMPPKKKAKNNSDEPTKQAKMDALPKNLPSRGGGASSSKSKGTSSKSGHKFREGSKVDGKSKDDFPKTENKSENANSVKSKDRTPRSGGSKSVGPAPKSGGKSKKNDPNTHKIGKFKDDNTSTPRASTKSKQNIEKTGKSKQDTPKSASLSKDKNPKIGGKSGVNGTGKMKSGSSSSKAKEREDMKDNSTDSAKVPRSTKGKSPTLSKAQGSDSKTGKKRRRGMTGK
The following text describes a protein:
Function:
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
Subcellular Localization:
Cytoplasm.
Domain:
Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
Sequence:
MFEYLYGTVEYKKMDYIAIDINGVGYRVYFPLREYEKIEVGNKYKLYIYNHIKEDTYKLIGFLDERDRKIFELLLKINGIGSSLALAVLSNFSYNKIIEIISKNDYTTLRQVPKLGEKKAQIIILDLKGKLKNLTYTEEETVSMDMLEDLVLALEGLGYNKKEIDKTLEKIDLNKFSSLEDAIKGILKNMRIGD
The following text describes a protein:
Function:
Involved in detoxification of xenobiotics, and vacuolar sequestration of glutathione S-conjugates. Together with abc2, required for accumulation of a red pigment (ade pigment) in the vacuole of a mutant affected in the adenine biosynthetic pathway.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MENFHHRPFKGGFGVGRVPTSLYYSLSDFSLSAISIFPTHYDQPYLNEAPSWYKYSLESGLVCLYLYLIYRWITRSFTVKQTVGSEFSGLRKAHGILLWLLSILFLGMTAFMFVNDAFPTAFSDPPVKICLLAYSVHLFLLHSLRMIYPRARPTLYHAAVLLNLLLLPPIFHFYSYPFFFVDHPPLSSYSPFLWFYFFITIVGNFIPLFTPRVWYPLFPEDNYQPSAEQVCSMFNFACSYGYLNPLVLTAKRRVVEVDDTPVIPDYDKNKAWTYRFERMKTPSLFITIHKIFWRQILGMGVSSFMVSVCQFLSPIALNRLLKHLESPSSSSVNPLVWIVLLLTGPFLTSLFTQFYLFMSTRYLARSYTTLVQQIYNKVIRSRFVQNKSGDSKVGRSNNLISTDVDDIGEIREFIHIIVRAPVEIAGSIYLLQKLLGWSAYVGLALTVLTCSVPIVLGPLVAKLTLRANRATDSRIELMSELLQSIRITKFFGWELPMLDRVKQRRQVELNRTWKLLLMEICIQVLVESLPVFSMFATFVVFTTIMGQTITPSIAFTSISLFSFIRTQFSWIAYLMRQIVQIFVSIGRVSDFLNDPDEVDPVNTIEDTSQEIGFFNASLTWVSNPSPGDFCLRDLNIVFPRNKLSIVIGPTGSGKSSLISALLGELSLNKGSYNLPRSKGVSYVSQVPWLRNATIRDNILFDYPYIEERYKKVIQACGLLTDLQSFVASDLTEIGEKGVTLSGGQKQRIALARAVYSPTSIVLMDDVFSALDIHTSNWIYKHCFQSSLMENRTVILVTHNVHLFMDSAAFIVTVKNGSAFPVTDKSSPLLFLAEQAASASEAAAPDLAAIPIPNEVDDAEAADEKDGKLVEEEQRVTGDVVFSEIFSYMKHFGSGFYVAAVLLFFVTTQATSILIDLWVAFWTNSSVNSPDVNNNKFLFVYGTMLLAYSLLDFLRTVSYDRGAWWASRKLHDSMLESVFGTFASWFDKTPTGRIVNRFAKDIRSIDMNLSGWLFFSINCFLSVAGGILSVSSAMPIFMIPAVIVCLAGYYFGLLYTRAQVGVKRLISIYTSPIFSLLGESIVGVSVIRAFNRQTIFKQMFSERLDNLVRLQSTSYNLNRWVAVRTDGISGLVGAIAGLIALLQKDLSPGVVGFSLNQAVIFSSSVLLFVRSCNSLQAEMNSYERVLEYSKLPQEPAPTIAGQVPATWPKEGDIVFNHVSVSYSAAGPTILKDVNLHINPSEKVAVVGRTGSGKSTLGLTLLRFTHRISGEIYINGRETQSVNLNALRQRISFIPQDPILFSGTVRSNLDPFDELEDNFLNEALKTSGASSMIMAHTDDQKPIHITLDTHVASEGSNFSQGQKQVLALARAIVRRSKIIILDECTASVDDAMDQKIQKTLREAFGDATMLCIAHRLKTIVDYDKVMVLDKGVLVEYGPPAVLYHNNGHFRRMCDGSGITFLPPETRGSKSA
The following text describes a protein:
Function:
Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Sequence:
MVCDFFFPQPGGVESHIYQLSTKLIDRGHKVIIITHAYKGRTGVRYLTNGLKVYHIPFFVIYRESTMPTVFSFFPLFRNIVIREQVQIVHGHGSMSSLCHEAILHARTMGLRTVFTDHSLFGFADAGSILANKMLKFTLSDVDHVICVSHTCKENTVLRASLDPLMVSVIPNAVVAENFRPLSHDAQKGERTSGEIERRPSPAPIGPDDTITIVVISRLFYNKGTDLLIAVIPRILASHPNVRFIVAGSGPQAIDLEQMLERNVLQDKVELLGSIRHEEVRDVMVRGHIYLHPSLTEAFGTVIVEAASCGLYVVCTRVGGIPEVLPQHMTTFAKPEEDDLVLATEKAIAALRSNKVRTDRFHDQVKMMYSWTDVAQRTERVYKGITGDISPEEFYGYYPGQGWEANADRVRSFALIDRLKRYYGCGVWAGKLFCLCAVIDFLLYVFLEMWFPRSNIDIARSWPKKLGPNGEKSHHLNRARTSQERLAP
The following text describes a protein:
Function:
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of non-histone proteins. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones.
Subcellular Localization:
Chromosome. Cytoplasm. Nucleus.
Sequence:
MEESQLPVYIHSAEYVELCDNLLSKVPRRASMVHSLIEAYGLLKEMRVVKPKVASMEEMAAFHTDAYLQHLHKVSEEGDNDDPETLEYGLGYDCPITEGIYDYAAAVGGATLTAAEQLIEGKTRIAVNWPGGWHHAKKDEASGFCYLNDAVLGILKLREKFDRVLYVDMDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDIGLGKGRYYSINVPLQDGIQDDKYYQICEGVLKEVFTTFNPEAVVLQLGADTIAGDPMCSFNMTPEGIGKCLKYVLQWQLPTLILGGGGYHLPNTARCWTYLTALIVGRTLSSEIPDHEFFTEYGPDYVLEITPSCRPDRNDTQKVQEILQSIKGNLKRVV
The following text describes a protein:
Function:
Serine/threonine kinase that acts as positive regulator of brassinosteroid (BR) signaling downstream of the receptor kinase BRI1.
Subcellular Localization:
Cell membrane; Lipid-anchor. Endomembrane system.
Sequence:
MKSSHKGKNHSTNLAFASPQYLHLGILIRESVTHSFGTLILDLMSGRHIPPNHALDLFQSKNYLMLMDSALDGQFFDENRRELMHIASRCLKTEPEERPKPLKLTPFGDASLRVDLCTIHELLEKLGYGEEDGVAHMHGDAAFRAKDFDMAIELVCQCYLMSEMFSEAMQAQLASLEWPIALYLQAGFFFKLEMEAEAQEALRYGSDLEPY
The following text describes a protein:
Function:
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MADNEAKARQKMAEGRKKLQGGGGFFSKVFGGGGGSGEAADLFIQVNNSSVVRDGLRNRSSDDEEEASSSEIECSYAGCLFIASNLLEYEEHYASHSFQCCECGTRFDTAHRLEVHHDEQHNPFFQIQLQRQPDSAHFKCLHPTCELKFCNTRTRDEHSRVVHFIQGDSSRRRRFDEIGTVLSNSMGGMSIDDEEGSGWTGGGNLFKMAKNWKEAGEAFLEAAEFYAKQGDSKHDCATQYAEAANCFRKIQPEVEVFQAKCLVLIMHYFQRAVQCLEKTSEIYTDMGRFTMAAKNHVSIAELYETELPDKEQCVKHYQQAADYYKGEEQKSSASKCLVKVAMYSAELEKYGQAIAVFEEIAFYEADHSTLKYAAKGHFFQALLCHLNIDPINTQQALQKYENASPSFSDSRECKFVKELLAAIEEKNEETFTECVANFDKISRLDNWSTSLLLKVKRTIEGGDDDEDDLR
The following text describes a protein:
Function:
Involved in a F420-dependent anti-oxidant mechanism that protects M.tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. In vitro, catalyzes the reduction of both benzoquinone and naphthoquinone analogs; since menaquinone is the sole quinone electron carrier in the respiratory chain in M.tuberculosis, the physiological electron acceptor for Fqr-mediated F420H(2) oxidation is therefore likely to be the endogenous menaquinone found in the membrane fraction of M.tuberculosis. Is able to use F420 species with two and five glutamate residues in its polyglutamate tail. Cannot use NADH or NADPH instead of F420H(2) as the electron donor; Is involved in the bioreductive activation of bicyclic 4-nitroimidazole prodrugs such as PA-824 and delamanid developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It converts PA-824 into three primary metabolites resulting from reduction of the imidazole ring at C-3; the major one is the corresponding des-nitroimidazole that generates lethal reactive nitrogen species, including nitric oxide (NO), which appears to be responsible for the anaerobic killing activity. Ddn uses the reduced F420 produced by FGD1 to activate PA-824. Delamanid (OPC-67683) is also reduced by Ddn to its des-nitro form.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MPKSPPRFLNSPLSDFFIKWMSRINTWMYRRNDGEGLGGTFQKIPVALLTTTGRKTGQPRVNPLYFLRDGGRVIVAASKGGAEKNPMWYLNLKANPKVQVQIKKEVLDLTARDATDEERAEYWPQLVTMYPSYQDYQSWTDRTIPIVVCEP
The following text describes a protein:
Function:
TIR-NB-LRR receptor-like protein that confers resistance to the pathogen Hyaloperonospora arabidopsis isolate Noco2 (downy mildew disease). Confers resistance to H.arabidopsis isolates Emoy2, Emwa1 and Noco2.
Domain:
The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Sequence:
MAASSSSGRRRYDVFPSFSGVDVRKTFLSHLIEALDGKSINTFIDHGIERSRTIAPELISAIREARISIVIFSKNYASSTWCLNELVEIHKCFNDLGQMVIPVFYDVDPSEVRKQTGEFGKVFEKTCEVSKDKQPGDQKQRWVQALTDIANIAGEDLLNGPNEAHMVEKISNDVSNKLITRSKCFDDFVGIEAHIEAIKSVLCLESKEARMVGIWGQSGIGKSTIGRALFSQLSIQFPLRAFLTYKSTSGSDVSGMKLSWEKELLSEILGQKDIKIEHFGVVEQRLKHKKVLILLDDVDNLEFLKTLVGKAEWFGSGSRIIVITQDRQFLKAHDIDLVYEVKLPSQGLALTMLCRSAFGKDSPPDDFKELAFEVAKLAGHLPLGLNVLGSSLRRRGKKEWMEMMPRLRNGLNGDIMKTLRVSYDRLHQKDQDMFLCIACLFNGFEVSYVKDLLEDNVGLTMLSEKSLIRITPDGHIEMHNLLEKLGREIDRAKSKGNPGKRQFLTNFEDIHEVVTEKTGTETLLGIRLPFEEYFSTRPLLIDKESFKGMRNLQYLKIGDWSDGGQPQSLVYLPLKLRLLDWDDCPLKSLPSTFKAEYLVNLIMKYSKLEKLWEGTLPLGSLKKMNLLCSKNLKEIPDLSNARNLEELDLEGCESLVTLPSSIQNAIKLRKLHCSGVILIDLKSLEGMCNLEYLSVDCSRVEGTQGIVYFPSKLRLLLWNNCPLKRLHSNFKVEYLVKLRMENSDLEKLWDGTQPLGRLKQMFLRGSKYLKEIPDLSLAINLEEVDICKCESLVTFPSSMQNAIKLIYLDISDCKKLESFPTDLNLESLEYLNLTGCPNLRNFPAIKMGCSDVDFPEGRNEIVVEDCFWNKNLPAGLDYLDCLMRCMPCEFRPEYLVFLNVRCYKHEKLWEGIQSLGSLEEMDLSESENLTEIPDLSKATNLKHLYLNNCKSLVTLPSTIGNLQKLVRLEMKECTGLEVLPTDVNLSSLETLDLSGCSSLRTFPLISKSIKWLYLENTAIEEILDLSKATKLESLILNNCKSLVTLPSTIGNLQNLRRLYMKRCTGLEVLPTDVNLSSLGILDLSGCSSLRTFPLISTNIVWLYLENTAIGEVPCCIEDFTRLRVLLMYCCQRLKNISPNIFRLRSLMFADFTDCRGVIKALSDATVVATMEDSVSCVPLSENIEYTCERFWGELYGDGDWDLGTEYFSFRNCFKLDRDARELILRSCFKPVALPGGEIPKYFTYRAYGDSLTVTLPRSSLSQSFLRFKACLVVDPLSEGKGFYRYLEVNFGFNGKQYQKSFLEDEELEFCKTDHLFFCSFKFESEMTFNDVEFKFCCSNRIKECGVRLMYVSQETEYNQQTTRSKKRMRMTSGTSEEYINLAGDQIVADTGLAALNMELSLGEGEASSSTSLEGEALSVDYMITKEQDEDIPFLDPVSDGTWRSFYSAE
The following text describes a protein:
Function:
May be involved in ciliary biogenesis or function.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Cell projection, cilium. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme.
Sequence:
MADVVLGVGTGVFIITLIWILTLALTIILSRATGPTKLGIIPVVLLALIITLVLVFFPRAAEVPAPQRAAQIVDMFFIGRYVLLSLVSLVFLAALFMLLPLHFLEPIYAKPLRTH
The following text describes a protein:
Function:
MKK3-MPK6 module plays an important role in the jasmonate signal transduction pathway through the negative regulation of MYC2/JIN1 expression. Activates by phosphorylation the downstream MPK6, MPK7 and MPK8. MKK3-MPK7 module acts as a positive regulator of PR1 gene expression. MKK3-MPK8 module negatively regulates ROS accumulation through controlling expression of the RBOHD gene. Component of the abscisic acid (ABA) signaling pathway that may act as ABA signal transducer in the context of abiotic stresses. Activator of the C group MAP kinases. Activates MPK7 in response to ABA. Mitogen-activated protein kinase (MAPK) that is specifically regulated by MAPKKK20 and mediates signaling that regulates cortical microtubule functions.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MAALEELKKKLSPLFDAEKGFSSSSSLDPNDSYLLSDGGTVNLLSRSYGVYNFNELGLQKCTSSHVDESESSETTYQCASHEMRVFGAIGSGASSVVQRAIHIPNHRILALKKINIFEREKRQQLLTEIRTLCEAPCHEGLVDFHGAFYSPDSGQISIALEYMNGGSLADILKVTKKIPEPVLSSLFHKLLQGLSYLHGVRHLVHRDIKPANLLINLKGEPKITDFGISAGLENSMAMCATFVGTVTYMSPERIRNDSYSYPADIWSLGLALFECGTGEFPYIANEGPVNLMLQILDDPSPTPPKQEFSPEFCSFIDACLQKDPDARPTADQLLSHPFITKHEKERVDLATFVQSIFDPTQRLKDLADMLTIHYYSLFDGFDDLWHHAKSLYTETSVFSFSGKHNTGSTEIFSALSDIRNTLTGDLPSEKLVHVVEKLHCKPCGSGGVIIRAVGSFIVGNQFLICGDGVQAEGLPSFKDLGFDVASRRVGRFQEQFVVESGDLIGKYFLAKQELYITNLD