lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Subcellular Localization:
Cytoplasm.
Sequence:
MMKQEEEYKKEFISIHIGQTGINLGNSCWELYCLEHGIQPDGMRSTTEDEDDDDRDYRFRTFFSETSSGKFVPRALFIDLEPIGGKIIDECLDRIRKLVDDCSNLSGFVIFNAVSGGTGSGFCSLLLESLSTEYEPKEKIAFTVYPSPDDEFSPSILDSYNTILASYSLNEHSNVTLMFDNVSVYDICRRSLDIENPTYVNMNRLVSQAISSLTVSMRFEGSTFNQNLRSFCDSIIGFAGCSYVPVLSAAKEVQHKQHSFVELTNAALEPSSYMVKHDPCKGNYMNNLIVYRGDDVDFDDVDNAVSMARTRTGFDYFDTAYRSGINYVPVTVYPGGDLATVQREVCVVSCTTSIQDVFTRISHKFNQMYAKKDFLHSYFCEGMEEYEFSEAYEEIAIKLVKLCQVYENEDP
The following text describes a protein:
Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MGDWNLLGSILEEVHIHSTIVGKIWLTILFIFRMLVLGVAAEDVWDDEQSEFVCNTEQPGCKNVCYDQAFPISLIRYWVLQIIFVSSPSLVYMGHALYRLRALEKERHKKKVQLKVELEESEALEEHKRIEKELRKLEEQKKVRKAPLRGSLLRTYVFHILTRSVVEVGFIVGQYMLYGIGLTPLYKCERDPCPNSVDCFVSRPTEKNIFMIFMLVISGVSLFLNLLEIFHLGVKKIKQTIYGSMYSDDDSICRSKKNSMVQQVCFLTNSSPQKQLHLTHTSLAMAPDGQMVPLPIYMQTAGHVVSNINPNGSVQPLRQDRLPSQPEIQVLQQLGIKERRSIPDNRLQSCSSEDSGPKGSEPPKYSQQPRASFRASHIEIPAALRKHSRVSQCKDFSEESDSVESGNYPTARKASFMSRGLSESPSESAASKSGSDTEANRITQGESPAMTPPPAAGRRMSMVRKF
The following text describes a protein:
Function:
Possesses phosphatidylinositol (PtdIns) phosphate kinase activity (Probable). Phosphorylates PtdIns(4)P and PtdIns(3)P in vitro. Doesn't phosphorylate PtdIns(5)P nor PtdIns(3,4)P2 in vitro. Does not exhibit phosphatidylinositol kinase activity in vitro.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing PI5K2 exhibit severe dwarfism and are enriched in the plasma membrane of the root meristem; MISCELLANEOUS: [Isoform 2]: May be due to intron retention.
Subcellular Localization:
Cell membrane.
Sequence:
MMREPLVSEEEEEEATEVLLVEKTKLCKRRGDEEKTEERRDDLLLLALTPMVRSKSQGTTRRVTPTPPPVDVEKPLPNGDLYMGTFSGGFPNGSGKYLWKDGCMYEGEWKRGKASGKGKFSWPSGATYEGEFKSGRMEGSGTFVGVDGDTYRGSWVADRKQGHGQKRYANGDYYEGTWRRNLQDGRGRYVWMNGNQYTGEWRNGVICGKGVLAWPNGNRYEGQWENGVPKGSGVFTWADGSSWIGSWNESSNLMRNFFDGIEKNELIVATRKRSSVDSGAGSLTGEKIFPRICIWESDGEAGDITCDIVDNVEASVIYRDRISIDKDGFRQFRKNPCCFSGEAKKPGETISKGHKKYDLMLNLQHGIRYSVGKHASVVRDLKQSDFDPSEKFWTRFPPEGSKTTPPHLSVDFRWKDYCPLVFRRLRELFTVDPADYMLAICGNDALRELSSPGKSGSFFYLTQDDRFMIKTVKKSEVKVLLRMLPSYYKHVCQYENTLVTRFYGVHCIKPVGGQKTRFIVMGNLFCSEYRIQRRFDLKGSSHGRYTSKPEGEIDETTTLKDLDLNFAFRLQRNWYQELMTQIKRDCEFLEAERIMDYSLLVGVHFRDDNTGDKMGLSPFVLRSGKIESYQSEKFMRGCRFLEAELQDMDRILAGRKPLIRLGANMPARAERMARRSDYDQYSSGGTNYQSHGEVYEVVLYFGIIDILQDYDISKKIEHAYKSLQADPASISAVDPKLYSRRFRDFISRIFIEDG
The following text describes a protein:
Function:
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
Sequence:
MSDNFVSFGEQGAQLTYGSYLRLPQLLEAQHLESDPPAHDELLFITIHQVYELWFKQLLHEVSAARDAMLGGEAGGRLWWAQHLLTRVHVIERVLVQQIDVLETMTPQEFLEFRQRLAPASGFQSVQFRELEFLSGAKDPAYLERFRGITPAEKARLDARLSEPTLWDAFLAMLRSFGFAADSDAEVSAALRTAAHDRTRYAVVWALSEGLLQHDELAANWRARHVVMVERMIGSKSGTGGSSGSSYLRSRLPVQYYPLLWGLRSEL
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localizes mainly in the nucleus.
Sequence:
MELMDDDGSSSLLEELMAPLRRGTPTTTPEDLWLQAYPMMMSPMCGDGVMLGDLLVGGGNARNTLASPPPPSFPLPVPLTTTTPCPPLHEVSFEFDSIDCLGEVCNPYKRSGGAVRATAAAQVMVAAMDPRREAASSAVAVAAVEEEERCKARRGAGGGGDSGELAPMFVFGGGGGAAASVRPRSCRPPQPGAPSKNLMAERRRRKRLNDRLSMLRSVVPRISKMDRTSILGDTIGYVKELMDRIKNLQVEAATGDSSSSSTENLSMLKLNTLKPPPSSSSGEETPLIRNSTRFEVERRENGSTRIEMACAAIPELLPSTLAALEALGVEIEQCVISCFDDFAMQASCLQDDKKREMTRDTEEIKQTLFRSAGYGDGCLI
The following text describes a protein:
Function:
Functions redundantly with Npc2b in regulating sterol homeostasis and ecdysteroid biosynthesis, probably by controlling the availability of sterol substrate.
Subcellular Localization:
Secreted.
Sequence:
MLRYAVIACAALVVFAGALEFSDCGSKTGKFTRVAIEGCDTTKAECILKRNTTVSFSIDFALAEEATAVKTVVHGKVLGIEMPFPLANPDACVDSGLKCPLEKDESYRYTATLPVLRSYPKVSVLVKWELQDQDGADIICVEIPAKIQ
The following text describes a protein:
Function:
Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MCPTTRPAFVLALAIALTNEVAESRDFNILAQNGLPDAAKGPGLTAASGKLCQLCEQYSTEALLYLKQNETQTEILSILHHECASLAPLKQQCITLVNYYVPLFFLEVSMVNPEKFCESVHLCKQGMKISLPTREGTCGLCHHVIVEVLVMLKDPNTQLEVIDLLLKTCSKAQNYEQQCKRLVLKYTPLILVKGQKFLETNDVCSAIHACRTGTQASMENIPLSATL
The following text describes a protein:
Function:
Stimulates smooth muscle contraction in isolated rat stomach strip.
Subcellular Localization:
Secreted.
Sequence:
MSLLPAVKVLPLGYLGIVLVFSLILRSAMVDFIQDAGKLERIDTYKREAQMIFGAPMWALGHLMGRK
The following text describes a protein:
Function:
Involved in the maintenance of cell wall integrity. Required for the replacement of the diacylglycerol moiety by ceramides during GPI-anchor maturation (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTEKTSSLVFSAQYVALVHTICSFAAFFIPLALALYTHYYQVVKNEFYGYPEEWFPSVSATIGDWYPERSVFQWLIALTATPRLLVLLLWFTLSGISRPSVIITTALGVLRTALCGGWVYVTSTDDHDWHDIFMIGYLISNAPWFILVSKCSPVNSMASRIRNIGSALFVLTIFPLIYWYIQHKFKHIPGAYTVYAFFEWSLILWDILFDSALYWDFKPLVFNLHTSKTYSNPSSFATRKKEKGEHLSYAEAAAVGTQAKNIKKDSNVKCSKKQILFSLLYFSSEVYLSFVFWSVLTSLGLLVWYFPLWHMGISGYEACILFELSPFLLGIPLLRKFASKVPVIFLFLNVIGIAAYKLEDPVHRLFVTAFSVCCECLAWTSLFSNISPENLAIERKISTFLFGLLASSIAKYSFFSNNPIWPILNETNGGKQIPALIVGIIACLIFAIFHVQQTTANAVEHFKLRKITALSAALSLGTVLFCLHTFLCDSTVLMTWSWDGYPIKGPQPYPHGAVSIVVSICAVLVAPYLYQSGAFMLIGFVLACFGSYFMYINHGWCSYLGGLIFTSYVLIYSFASIRISSFYSPAKVWGGAFLVYILYSLAHVWVVAYEFVPGGPILRERTSYILIFIGWNLAALVPAYSGESKEPNKADSSVVDIKQSDSSYRRRSFKKSLLTGFCLALMALKFAIQNMPPYDYTPYHPNEKLFTAGIWTIHFGLDNFMYASENRIRDAVRDMELDVFGLLESDTQRLIMGFRDLTQVLAHDLGMYADYGPGPDKHTWGAALLSKFPIVNSTHHLLPSPQGELAPAIHATLDVYGELIDVVVSHNGQYESQLDRRLQSTELARIMRESPRPLVFLGYVVSNVGQEPQTILTRDTGMLDIEPADYDRWCQYIFYRGVKRIGYARLHRSTITDTELQTGKFLVTKDLGRNVRIDKEHVPESHRYPSLFEGTGVNGHYYDNNLVVHEPWYYD
The following text describes a protein:
Function:
Component of the exocyst complex involved in the delivery of secretory vesicles to the plasma membrane. Also required for polarized cell growth and division septum assembly. The exocyst complex plays an important role in the targeting of rho3, as well as the two main hydrolases required for cell separation, eng1 and agn1, to the cell wall surrounding the septum before cell separation begins.
Subcellular Localization:
Cytoplasm. Cell tip. Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Note=Associated with the actinomyosin ring at the division site and at the cell tips.
Sequence:
MDTRGYSETKKGRYPVGKKSLESPNGYSNYGTSMDNELSSEYASRGMHIGDLENLVNEIEDEWKDLGREDYQPISTALELLDDSSFGRDYKSFLNVYDRISAALQTIAHTHKDDFTRGISAYGEIMEGIQKCNSRIIALKQSLEASQECIGNTNSKELQQTLARSSQYKKVISVLKELNEANQLFDNFHTLVDSKQYYHASDLIRRVWDELSRSDFDGILVVEQFKSRMTGLLSHLEDILSEELVSITFLKDAVAYPIVSYCSPNPLRETSNPYFLRDFLKNNANTSTLGQSEQLRYLEEALSLKLSDCLKMDYGRDSLRDIRIVLESLNLLGKLPNAISSLKSRTSAEMFTTVDSTSRAIVNKYSLGNNVSTVNPFSKSLYDIGLHAETDREHTMISEFLTNLFTKLRCVLMHYRGISEFMTKLETKTPKHASSSHKSSIMSVNSDPTSPKVSKFDTSDSTFPFDTLLQAFESEIRLMLKDYLISKEEYIENSGNFVVGTEMSIYNLPGENEEDKLFDVTNEIAVENKSNAFYARINELVNEKAPELILNKSNASVSTIELFSGSSKEIVRLAGHVVFVGPSVFHASSVLPQTVFFLEDSVSILKNPNIPPQFAVNFMKEFLRGSYIPQLYKFMSSHFDTIMKDVGAFQLHRDWKIYSKIPIFKCHVAIVQYFHDLQDYLPIVALNLVEFYELLHTLLVRFRNHCSDYLSDLCRTAVLKEYKHVNEDTEDVDDTVRVKLLHDDVTYPQFIKFLKQKNPSLEGLNELCRMENKRLLQYEDRAITSEVKLPVSVLSKDSDLVNSVSYLHNSMEWFLQRCFSRFMNGSRRMNVLQQNQANFGGDFLPIDNLLGNNSDLMKGAYKEVFDSLQRLQFDALLLIRMEVRLQYIHSINQSVNLPDYVVEYRGRPDASIMALNSTIVTTNLKLETCLNEWERRFVFQGLSELVDSSLYSIFYKIESMNRGSCLQMLKNMSAMIQILKTVKEIHGDVEFPKSSRVFGIYQNGAKKIIEHFIAAPKKELLPDVKQMVRIYYQRLMKDAKRNGRDDLYRQYQKKIGSVLTQFDNTVGGARKNP
The following text describes a protein:
Function:
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
Subcellular Localization:
Nucleus.
Sequence:
MESLLQHLDRFSELLAVSRTAHVRTWDPVTVRRALQWARYLRHIHRRFGRHGPIRTALERRLHNQWRQEGGFGRGPVPGLANFQALGHGDVLLSLRLLENQALGDAARHHLVQQLFPGPGVPDADEETLQESLARLARCGSAVHMLRFNGYRKNLNLQEDSLMKTQAELLLERLQEVGKAEAEGPSRFLSRLWERLPQNNFLKVIAVALLQPPLSPRPQEESEPSIHKTPGEGSQALVHWLLGNSEVFAAFCRALPAGLLTLVTSRHPALSPVYLGLLTDWGQRLHYDLQKGIWVGTESQDVPWEELHNRFQSLCQAPPPLKDKVLTALETCKAQDGDFEVPGLSIWTDLLLALRSGAFRKRQVLGLSPGLSSV
The following text describes a protein:
Function:
Major function may be to aid in digestion.
Sequence:
MKLFVFLALAVAAATAVPAPAQKLTPTPIKDIQGRITNGYPAYEGKVPYIVGLLFSGNGNWWCGGSIIGNTWVLTAAHCTNGASGVTINYGASIRTQPQYTHWVGSGDIIQHHHYNSGNLHNDISLIRTPHVDFWSLVNKVELPSYNDRYQDYAGWWAVASGWGGTYDGSPLPDWLQSVDVQIISQSDCSRTWSLHDNMICINTDGGKSTCGGDSGGPLVTHDGNRLVGVTSFGSAAGCQSGAPAVFSRVTGYLDWIRDNTGISY
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MTDIEVANYYNLPSAYPEEWPAELDQSEPSDDEEALGRTPSRARRSRYFALERSHSGKALSLGPFKGSNARENLAKVDEPDPLGSGDSVLQILKKRGLSLEDESRLRNRFLLSSTSFSPALFLSQVHSDASIESLLEGLNFLSRSIDQKSASLKVLVEANFERFVRAKATIDSVYTEMRNQGKEKHVPLTQAHRRSAGHLRSISGASRSAPLADDRPGKNALTKESDYGMKGIRVPLLEASVKAEEVWGPALGGREREQMLKSVVDTMEKHRDVYEIGGLLSKSIKLRDYDSVFEQYTKARTLAKSAKHIAHKATSSGRSLTDEETHAILAMGRMWMDVDHQIQAFKRDLWRRLSDAPTTSTTATADGTVEEYMELIGALLELGVDDNPIWVWLLSRYDFLKTKIGAFCGRCKMEIEILRRRLAGGDKPTPKAVASYLRLAPREESAELQGVLDTDQVVELWECILAYLNKLLASQGGLLGEVFDFWEVAQSFIDGSRQKLLPVGFEGESRRHHRLSESETRKLQTGVVELVNLIRENVLSLFADPPLDDASFLASPISPATPNSPISQGVTPTESRFKLDPKNMPIPTPKRGEFWEDYAFWPPFSNSLSGVHYLGQFMIIIGTAASEMAALNPVASGGNTHDLLKSLVSIARERSVRVACAAWGKDAEICKMLEDWTRDPESKDLTKMPGLFVAFESAILGRMQKILYISEAMAKSGAVDVVTQPPAKLLQMVRTQFVSSVYKALSGLVENAEHPVGLDEGSEWILAGSAVQVHGSDSTSPALAADTVDSQDRNVRILLTLSNIKALQAEFVPHLVTNFETSFSVKLTEEAKTIRDVLGQIDDRLFQSYTKPTVNKLNTMIVSGITDPEWEPSSGRPEQVRPYVYSVLLTLVLVHTEISTTIPSCVASGASRSPPAAPSPLLNMVLTHLLTQISTSLLNAFRSRPSYTLAALMQATLDTEFIAQTLSQYSTEEASTVQSQIYVELDQRTTHEARARLQSELGEMRSILKRLRERTKGEFACFKKPRSGTGHKAA
The following text describes a protein:
Function:
Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Constitutes the pore-forming subunit of the MAC complex: during MAC assembly, C9 associates with the C5b8 intermediate complex, and polymerizes to complete the pore.
Subcellular Localization:
Secreted. Target cell membrane.
Sequence:
MGCIKSSVSVLLNFPHPSIDIIISIGSMSRLLLLTGVLFTFGINSFVSTERIRLPRESNAPPPVECLLSNWSEWGPCNPCVKERYRSRSVLKYGQFGGKACLEPLGHRESCEPDVPCREEEVDCGKDFQCENGQCIKTRLVCNTEDDCGDMSDEADCEDNRPAPCRDRILDVSELGRIAGHGINVLGMRPQASPFYNEFYNGVCDRVRDGNSGIYYRKPWNVAVLNYETRGGKNFRAEYYADQVTALKEVLSETQQTFKSSLSLKMNPTEISEGNTSALTNLSTSFTTVHSSSIRDYLRESKGKEQLFLHVKSSIELGSFIMRTRDLRLNDWFLDDLKNLPTTYDRGEYFKFLETHGTHYARKGTFGGKYELLYVLDSETMKKEGVTITDVKTCLGYDVEFGIKTSDFDAKLPISKVKCTTDKMRQVSNKTTVSLINDVVSIVQGGKITVLIKLKEQLSKGNKVTNIEDYVEWAATLPDAPVIISQELSPISDLVPLKMPDSTIKKRNLDRGVEDYIAEYNVCKCQPCQNGGTVLLINGNCECGCTPYFKGDVCQTPTSTFVPGQVATNGGWSCWSNWSPCKEGQRTRTRQCDNPEPTAGGNPCAGSNSEIGYCSSAE
The following text describes a protein:
Function:
Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus.
Sequence:
MEEITKNKTVDKEESIETKTKKDVGTESVKSIDLPIKEFQKSFRLLNENFNIKDLENVLTPIEYAEYNSFLAYSICSIFYSYLKLSGDVLTNHPIKNELKNVQALMKEIKEKAKTNVEEKRSLTINKEASKRIIESSISYNKHIKKNKN
The following text describes a protein:
Function:
May bind F-actin and nucleates actin assembly.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MKFQHTFIALLSLLTYANAYDYFTTTLANQNPVCASVDVIQNVCTEVCGRFVRYIPDATNTNQFTFAEYTTNQCTVQVTPAVTNTFTCADQTSSHALGSDWSGVCKITATPAPTVTPTVTPTVTPTVTPTPTNTPNPTPSQTSTTTGSASTVVASLSLIIFSMILSLC
The following text describes a protein:
Function:
Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play a role in development or function of the auditory system.
Subcellular Localization:
Secreted. Cell surface. Cell projection, stereocilium. Note=Secreted protein which may bind to the cell surface via a membrane receptor.
Sequence:
MSALLSLCFVLPLAAPGHGTQGWEPCTDLRPLDILAEVVPSDGATSGIRIVQVHGARGLQLSVAAPRTMSFPASRIFSQCDLFPEEFSIVVTLRVPNLPPKRNEYLLTVVAEESDLLLLGLRLSPAQLHFLFLREDTAGAWQTRVSFRSPALVDGRWHTLVLAVSAGVFSLTTDCGLPVDIMADVPFPATLSVKGARFFVGSRRRAKGLFMGLVRQLVLLPGSDATPRLCPSRNAPLAVLSIPRVLQALTGKPEDNEVLKYPYETNIRVTLGPQPPCTEVEDAQFWFDASRKGLYLCVGNEWVSVLAAKERLDYVEEHQNLSTNSETLGIEVFRIPQVGLFVATANRKATSAVYKWTEEKFVSYQNIPTHQAQAWRHFTIGKKIFLAVANFEPDEKGQEFSVIYKWSHRKLKFTPYQSIATHSARDWEAFEVDGEHFLAVANHREGDNHNIDSVIYKWNPATRLFEANQTIATSGAYDWEFFSVGPYSFLVVANTFNGTSTKVHSHLYIRLLGSFQLFQSFPTFGAADWEVFQIGERIFLAVANSHSYDVEMQVQNDSYVINSVIYELNVTAQAFVKFQDILTCSALDWEFFSVGEDYFLVVANSFDGRTFSVNSIIYRWQGYEGFVAVHSLPTVGCRDWEAFSTTAGAYLIYSSAKEPLSRVLRLRTR
The following text describes a protein:
Function:
Part of ribonuclease P (RNase P), a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Binds RNase P RNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MRRNSKERKNRATRRSQGSYQEIIGRTWIFRGAHRGRVTRRNIIWHELIGLRVRIVGSTHPAFVGIEGYVIDETRNMLVIAGDRIWKVPKDVCIFEFEADDGTKIKIPGERLVGRPEMRLKKRWKKW
The following text describes a protein:
Function:
Involved in the translocation of the TcpA pilin.
Subcellular Localization:
Cytoplasm.
Sequence:
MSIDIKYLSRIDIDREEFFFKDSRLMCKKFDEEREVLTLLEFDTKFRVNLLKKDKVYKYFLVSDANHKLLIANLVTEQQAKDLSFIEKDIMKIASSATAYGASDIHFIREDRICKIKFRVNGTMIDYREILSSEADALMFVLYNVMATTKETTWNRKLPQDANIILVINEKAYRFRYAHMPLFGEGGKNYHAVVRIIYPSNNFVCTNYQDIGYNEADTDAIARILNTSYGLFIVSGTTGSGKSTSLKKYIELLFFNKYKGKGCFVTVEDPVEYLISGAQQSSIVADNDDKTKNPFADAVRSAMRRDPDVIMIGEIRDKPTVEALSSAVESGHYCLTTIHAGSVVSVLQRLSGLGMKADKIASPGFLAGITSQKLIPELCPSCKVSFVDERYQRAVFSANENGCEACNHSGFKGRLLLLETLVPTVEDLELVASENWVSLYRKYRERRFIKTGKKGLGEGFSIKDKAYYNVLKGKVCHEYFMLHFGQLDHEDENIIYENYLQEV
The following text describes a protein:
Function:
tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
Sequence:
METHCNFWLPKKKRFCANTLLKDSQFCGNHTQRSNGQWIPCPIHPSHSVLEENLQSHLKRCPFYKQAQSLLLQPYYQEGINAGKEQQGDQNFSSEMKRNAVHSMTPFQFSLLINKIKSLHASLCNDIRDSFKIPQACDIWTNRQVDRTLPFQEKHVMQQASILGNLEEFGVLKVKLETSVDDDDGVPAVVEFGAGRGYLTQVLTDCYGIDKILLVERKSYKLKADRSLRQKESVTLERLRIDIEDLKLDAVESLQGVPYLAIGKHLCGPATDMTLRCCIREQCDDSPSESTCPMIGLAIATCCHHLCQWKHYINKQYMLNSGISKDDFNAMTWFTSWAVDADHGSDLSGTDWSFDLQIRENEHVESDLNTYEVKDMVKNMKAVDRAVVGLMCKDIIDVGRFMWLKEHGLECELVKYVQSNISPENRLLVARQKS
The following text describes a protein:
Function:
Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
Sequence:
MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQTDDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDPPIPGHYKSVAIEITRKKS
The following text describes a protein:
Function:
Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MSLRRLSPSHLILGTLVLGVIIFNLYVLTSTHEDIKKVKGPTYHTSDNTKIQSHISNYDSEEYVDRLTAEIEDAKKEELISEIRKKLEIQEKPGVIQKLKTELRMKYIDDIKNHLKQEITEQYSNEIFKQYAFSFEIYSKKVDEYALQLENSLKPASCLAILQQAEKDTDSIPDLENYLTKANDKYFKRQEYWRYLLKDILLNNKPKCEPLTKEEKGEKLNPTYQWDARIISEQYLLGSKLTIPGEKFRALRSAHDQVVKQLKSLPDPPSQFISGHGIVVNGGGNMIGSALTAIANMRERGSQLPVELILDTKQEYDKQICEELLPKKLNGKCVIVEEQVGKEVFDIINEKFSRKIMGLLVSSFDHIIAMDADNLAIKNVDNLLFTEPYLSTKMILWPDLWVKLTSPLYYKIARIEPGEIVDRFGIPNDASFAEYITKDKQSEVHYHDLDNLPSTISVETGQMVFSKREHLKSLLLALYYNINGKDFYIDLLYQGAYGEGDRETIVPALHVMNERYSLTNHKVHILGYDAPNGKYSETTLGQTDPRDGFEFYQDWRKFLTSRKLDTRLNPFQSGGYTSDLMKQFHDYKRQIYQDKQYEDEAAVHRMITYKLPSILFLHCNHPKIDPLKNSKEADAEFGVYSRRNMGLPDKVEKLLEGKDWELRFHTISQWVACEAISKSSLYWEKIAGKSQQQVCESVGKYIEFLKKDTFDNEATKLTILNQLGEKSQPKQPEINNNNNNNNNDDDNGKNKQGAAS
The following text describes a protein:
Function:
Global transcriptional regulator that complexes with cAMP and binds to specific DNA promoter sites, causing DNA-bending, to regulate transcription. cAMP improves binding to specific DNA sequences, probably by altering protein conformation. Involved in the regulation of gntP and gntK genes, which are involved in gluconate metabolism. May form dimers which bind to the aceB promoter region in the presence of cAMP and repress the glyoxylate bypass genes. It could be a positive regulator of rpf2 gene expression during growth on acetate as the sole carbon source, however because the cytosolic cAMP level is elevated in the presence of glucose and low upon growth on acetate, it is conceivable that it is unable to function as an activator under acetate conditions.
Sequence:
MEGVQEILSRAGIFQGVDPTAVNNLIQDMETVRFPRGATIFDEGEPGDRLYIITSGKVKLARHAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSAVCVTEVHAATMNSDMLRNWVADHPAIAEQLLRVLARRLRRTNASLADLIFTDVPGRVAKTLLQLANRFGTQEAGALRVNHDLTQEEIAQLVGASRETVNKALATFAHRGWIRLEGKSVLIVDTEHLARRAR
The following text describes a protein:
Function:
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
Sequence:
MVQKKMLTHPELFSRLVDGPERIRESVQVPKPITGCPDGITKTVWDVLTRSAQLNPNAPLFGESVNGRHVYTTYREAVEEATIIGSGIVAIMQKNQSTNKLIGIAGIHSRKYMHTMHGISGFDLTTVPLYHQSKLETLCDIIDNCKLEIIFCENAKRAEGFLSSKLGDRLRSLKTLIILDKTTTLQKHDDVEVMSLDEFKEIGKRNKRNPVKPKPETTYVICHTSGTTGRPKGVEMSHGSLVTSVSGIFTSWTIAYKWKFGLEDTYFSFLSLAHIYEHLIQTLTIYFGGKIGIYDGNTATLIPQIQKLEPTIVSLVPRLLNKLYEAVHDGVAKKGFIARKLFDYAKKTKARQLQRGVLRYDTFFDKIVFKKLKLMLGGKLKVLTSGGAPITKEVKTFTRYAYGCPLVEGYGQTECSAAGTLTLPWDTTYGNVGGPAPWAQVKLVDVPEKNYFSMNDEGEVCFRGNAMMTGYFQDPELTAKTIDSEGWLHTGDIGKWLPTGGLQIIDRKNEMFKLSQGDFVSPIQIEAIYANSPLITQIYVTGKTERSFLVGIVVLDLPRFKQLPLVKALDGKESIEMIMENKEVKNAVIAELNKYAKQNGLQTIELIRNVHLTLQEFTEENGLITSTLKNRRKILEDYFAPQIAKMYKEVEAL
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
Sequence:
MSTLYLTQPDAVLSKKHEAFHVALKQEDGSWKKQPIPAQTLEDIVLLGYPSITGEALGYALELGLPVHYLTQFGKYVGSALPSESRNGQLRLAQFRAHEDPIQRLDIVKAFVKGKVHNQYNLLYRRGQVDNPLKGRGKLVMRQQTLEQVRGIEGLAAREYFASWQEMLGHEWTFTGRFRRPPTDPVNALLSFGYGLLRTQVTAAVHIAGLDPYIGFLHETTRGQPAMILDLMEEFRALVADSVVLTVLKQREIQRQDFTESLGAFRLTDSATKTFLGAFDRKLSSEFKHPIFNYKCTYRRAIELQARLLARHLQEGVVYEPLVIR
The following text describes a protein:
Function:
May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. May regulate ITCH and NEDD4 E3 ligase activity and degradation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MLELRQRSPALGGRAARVQAPRGRSRGRETRAGAGRRGGGGRGGGGRGGAGQRGGRGGSDGAGRRERREGGRAMWLLGPLCLLLSSAAESQLLPGNNFTNECNIPGNFMCGNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFQCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGIQYVASQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQGDLPPYRSRSGSTDSAGSQGASSLLSADDSSPPDGAAGPRDPEPGQAAARV
The following text describes a protein:
Function:
Required for DNA interstrand cross-link repair. This requires cleavage of cross-linked DNA to generate DNA double strand breaks (DSBs). This protein has 5' exonuclease activity on single-stranded and double-stranded DNA, which appears to be necessary for the processing of DNA double strand breaks prior to ligation.
Miscellaneous:
MISCELLANEOUS: Present with 259 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSRKSIVQIRRSEVKRKRSSTASSTSEGKTLHKNTHTSSKRQRTLTEFNIPTSSNLPVRSSSYSFSRFSCSTSNKNTEPVIINDDDHNSICLEDTAKVEITIDTDEEELVSLHDNEVSAIENRTEDRIVTELEEQVNVKVSTEVIQCPICLENLSHLELYERETHCDTCIGSDPSNMGTPKKNIRSFISNPSSPAKTKRDIATSKKPTRVKLVLPSFKIIKFNNGHEIVVDGFNYKASETISQYFLSHFHSDHYIGLKKSWNNPDENPIKKTLYCSKITAILVNLKFKIPMDEIQILPMNKRFWITDTISVVTLDANHCPGAIIMLFQEFLANSYDKPIRQILHTGDFRSNAKMIETIQKWLAETANETIDQVYLDTTYMTMGYNFPSQHSVCETVADFTLRLIKHGKNKTFGDSQRNLFHFQRKKTLTTHRYRVLFLVGTYTIGKEKLAIKICEFLKTKLFVMPNSVKFSMMLTVLQNNENQNDMWDESLLTSNLHESSVHLVPIRVLKSQETIEAYLKSLKELETDYVKDIEDVVGFIPTGWSHNFGLKYQKKNDDDENEMSGNTEYCLELMKNDRDNDDENGFEISSILRQYKKYNKFQVFNVPYSEHSSFNDLVKFGCKLKCSEVIPTVNLNNLWKVRYMTNWFQCWENVRKTRAAK
The following text describes a protein:
Function:
Not known, could be involved in the transport of ribonucleotides.
Sequence:
MRYSDSYHTTGRWQPRASTEGFPMGVSIEVNGLTKSFGSSRIWEDVTLTIPAGEVSVLLGPSGTGKSVFLKSLIGLLRPERGSIIIDGTDIIECSAKELYEIRTLFGVLFQDGALFGSMNLYDNTAFPLREHTKKKESEIRDIVMEKLALVGLGGDEKKFPGEISGGMRKRAGLARALVLDPQIILCDEPDSGLDPVRTAYLSQLIMDINAQIDATILIVTHNINIARTVPDNMGMLFRKHLVMFGPREVLLTSDEPVVRQFLNGRRIGPIGMSEEKDEATMAEEQALLDAGHHAGGVEEIEGVPPQISATPGMPERKAVARRQARVREMLHTLPKKAQAAILDDLEGTHKYAVHEIGQ