lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) or PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)) on the fifth hydroxyl of the myo-inositol ring, to form PtdIns(3,5)P2. Required for endocytic-vacuolar pathway and nuclear migration. Has a role at a late stage in endosome-related membrane trafficking, at a point when signal termination has occurred. Is not required for receptor silencing.
Subcellular Localization:
Endosome membrane. Note=Mainly associated with membranes of the late endocytic pathway.
Sequence:
MTSNNQNNSSSHQHLHSPSKLTEFARNFEDKPESLFGRVVNKIQNVYNQSYNTVNDISSGSSSSSSTQPVQVVGKSQFFSDSQTSTAEIADVETSSQSSVRPQPPTTLSIRTNSETRGTSTSSNTAAEDSETSDRVETLPLPTSEANQGRTVSNVLKHISNIVATKNNNDLRNYKDTELQRFWMPDSKAKECYDCSQKFSTFRRKHHCRLCGQIFCSKCCNQVVPGMIIRCDGDLKVCNYCSKIVLTFLKSSSSEMGQDMQELQQHLSNKLEVQDSGSSLAKHPQMQRAPLPRKTSVGYQEERFSSHPTYTTLSIDDRKNILQQSNSLITLHEEMQRDLPAQNCGQRLIEFLNSNNKSANEVQAVAILNAMLAAGFLEPIVPDPEQMDFDSSLHYKFSKSSSSDTSRTMSPQFEANPHAEPQPPKSMDQSAEEKEKELENELENDRCYTTATSKLLASYCEHEEQLLAQMLRAHNLDQEWDKVLQMLCSTAANHFKPEHCSNDLMDIRNYVNFKKVPGGRRKDSKIVHGVAFSKNVAHKDMATHVPFPRILLLQCPIVYERIEGKFVTIETVLLQEKEYLRNVCARIMSFKPNVVLVHKNVAGIAQDLLRSYEVTLVLDVKLSVMERLSRTLQCDIVSSIESNITMPKLGYCNDFYIRNYNGKTLMFFEKLTNPRGYTCLLRGGSNAELTRVKRVASALLFARYNWRLEMSFLLNEFAQPLSPKPSIFDSKETSPKTETEAELRSKRPIILERKSEDKITTIVSENVSDFTDPLRASQAEALSTSPCAPPVVEALAVEPRYDNRFRTALSSTLLSVSPFLTFPLPYLETEQGRKCKLRKLFPAELYFSKQWSRTGLERPDSMGDGEAGKSEPGNKENQMQLLPAHDFVLMKITAPASSRDIQSKLAEFRSFGGRLPKGKAPMLRPKKKNAEVIQRPQKVSEEQLYKDALDPQNHQRLPVLFCSFHYNPKGVSSFCKLPMLLDMKFYGQYDIMLEQFLQRYCCLFNSMCPSCNLPMLGHVRRYVHSLGCVHVYLTEDLTRSDPTRIYFTSWCSICNATTPTIPLSDAAKCLSLAKYLEMRFHGHAYKRRPPSTDAEQGGTVCEHSLHRDYVHHFSFRGVGAKFQYTPVEVWETDLPSLTVQLDLPQPFQSAQVQEEIKNFSIKGHEVYNRIHERIADLATEEENSPLVQHLKTMLTHDQFIFKQKIEIVHTLLTDNRATAYDTSDALAMARRALAESIELWGPRLQEIEKLTAKQAHHIDSGTICTEELRPEQVQTADSSKVTTSSLPKENDPLECPSEDTETGASNSQTVLDKNFSIDQMLASTVNVYSDKKSIRKILTQLLPSGNQVNPLQSPFPAQDHLTLPLGSIPIHVRETDLSSVIAYSLTSMDYQKAIDEAEANSNAAHSSPQLKRKIPLAESVSDAEDSPSLSRTSSNTSAAPNASVPSPATAASESEEKSKERIKQPPSPHITLAFQDHSCQFQCKIYFAREFDAMRSKSLKPPKLDKSLYRRLEKSKMREELRISQSRTGSEMELVRKPSDVGAPRTTEDDSNQEEDARIALARSLCKSVQWEARGGKSGSRFCKTLDDRFVLKEMNSRDMTIFEPFAPKYFEYIDRCQQQQQPTLLAKIFGVFRVSVKKKDSFVERSVMVMENLFYGCNIENKFDLKGSERNRLVDPSNQQGEIVLLDENLVQMSWSKPLYVLSHSKTVLRDAIQRDSSFLEKNLVMDYSLLVGLDKKNGVLVLGIIDYIRTFTLDKRVESIIKGSGILGGKGKDPTVVNPERYKQRFIDAMDRYFLTVPDRWEGLSKV
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.
Subcellular Localization:
Nucleus. Note=Nuclear rim.
Sequence:
MDGNEIAHAKKLVYDLYSGSLSPSAIAATEKELQKAQRSQQGWNIGLFMLQSKDVYEQFFGALTLQMKINTQLETLSDKDLVQLFVQLLQKLLWDDGLPALVERKVICTLASLTIKYELEKKEEASLKVIYCLFCNKLEFFNADMNAASVLNNLFPPASSRNAQLTASYINELLLELSFSIYTKENEDALFNNVFRPCSNIIVSVLVFIFTNYSLDLSKEKNVAALEEALNCMIAISSYLAKASVSVQSVLPAFTECMDLTVNCIALDEVSEKAMNCLADLLANYSNFITQPTIERLWTILTGPWGETHLQQELEDPDSGEENDYSFLNIVIGFAEAMLPQIIDHIQEEKSIRLLYILASLLSFPGYAIVEEKVSWRTLEFWTTLIEDFSMSKAATDPSKDEIFKQIAFSVVEKAWWKMLLPSPEQWNSWPSSSRDSFNSYRRDLGDLLESSYSIFGERLYAMYITTIENFFSDGTGSPQSLEVSFYCLCCILEYDTNDSDTLDAWLTRLFETSFAIKASAFQNPQLLKTCSQLLSSCSCFLQNHPQYLNISLPVLFDALHISETSIQMTVSRSIHTLCTTCASHLLTEIDGFMAVVEELTPKLVYVPSVLEKIYSSVGYVTQRIEDIELRISYLMRLLNCILAQLQPSLYPNLEIFENVLKSCLQSVAGVALSQSPIGESPIIDVEQSTQETTFWQQSCIAEFQAKLISFLTHSESMALQYSDVVGLICKIMIAGLNEVEPSPFSLPIVTTIQYFCDRFTEFPAAVLLTLGSAILTCPYGQTDIIDKVLIDMCSSIQNSVVIINEESFMNNIDITVELYHFFSIILQKHPSFLETMYPDFTQLILNRAINLLGKPERLLESAAGQFIISFITSEKSDLLNTHTDFVNAIRSPLIAKILLGFGGNASRSSLPLLSDILGKLKAQNFSATRACLTQSLEEEGFPSRNVSNEIKRRFLTDLLKARIKDKVKQFWILCKGLESTPYGNSSWTF
The following text describes a protein:
Function:
Probable carboxypeptidase.
Subcellular Localization:
Secreted.
Sequence:
MKNGKFGCFFLLFLGCFRSAFANQNNDRITWLPGQPDNVEFAQYSGYVTVDKSAGKALFYWLTESPSNPESKPLLLWLNGGPGCSSIAYGSAEEIGPFHIRNDGKSLYLNPYSWNKEANLLFLESPVGVGFSYSNRSSDLYTLGDSRTAKDAYKFLVRWFNRFPQYKHREFYIAGESYAGHYVPQLSQLIYRRNKGIAEPEINFKGFMVGNAVTDDHYDYIGTFEYWWTHGLISDSTYKRLKTSCSGSSQHPSITCNTALADADSEFGNIDPYSIYTRPCNSTASLKRSLRGHYPWMVRGYDPCTERYSNEYFNRPEVQLAMHANTTKLSYPWSTCSDIVGTYWSDSPESMLPIYRELIAAGLRIWVFSGDTDSVVPVTATRYSIDALRLPTVANWYPWYDNGRVGGWSQVYKGLTLVTIKGAGHEVPLHKPRQAFILLNHFLKNRSMPPQSL
The following text describes a protein:
Function:
Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
Sequence:
MHELSIAHNIVTIASDAAAEAGVDRISAVHLRIGALAGVVADALRFSFAIAAEGTPLAGAELIIEEVPVVVFCPDCNAEVTLTNPRLFRCPRCDRPCGQIVHGRELELVALETP
The following text describes a protein:
Function:
At low cell density, in absence of AI-2 (autoinducer 2), LuxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to LuxU, and ultimately to LuxO. At high cell density, in the presence of AI-2, the kinase activity is inactivated, and the response regulator domain has a phosphatase activity (By similarity).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNIRPSQIKHKQRIASFITHAVVVVMGVLIVSVLFQSYQISSRLMAQEGQRTSVQTSSLIQSLFDFRLAALRIHQDSTAKNASLINALVSRDSSRLDEFFSSVDELELSNAPDLRFISSHDNILWDDGNASFYGIAQQELNKLIRRVAISGNWHLVQTPSEGKSVHILMRRSSLIEAGTGQVVGYLYVGIVLNDNFALLENIRSGSNSENLVLAVDTTPLVSTLKGNEPYSLDYVVHSAKDAMRDSFIVGQTFLEVESVPTYLCVYSIQTNQNVLTLRDNFYFWMAFALISMIGVSIASRWWLQKRIQREIETLMNYTHKLMDLDTKSEFIGSKIYEFDYFGRTLEQSFRRLANKEKQFEDLFNFALSPTMLWNTSGRLIRMNPSAQIQFLREDAQNHFLFEILERQLLPTITNAAQGNNPSDVTTEVDGRVYRWNLSPIMVEGQIISIITQGQDITTIAEAEKQSQAARREAEESARVRAEFLAKMSHELRTPLNGVLGVSQLLKRTPLNDEQREHVAVLCSSGEHLLAVLNDILDFSRLEQGKFRIQKNEFRLKELVCAIDRIYRPLCNEKGLELVVNSNITTAAIVRSDQIRINQILFNLLNNAIKFTHQGSIRVELQLIEGDPLAQLVIQVVDTGIGIREQDLTVIFEPFMQAESTTTREYGGSGLGLTIVHSLVEMLSGQLHVSSEYGIGTRFEIQLPIELVEKPDAPQQLLPAPDPQPLFDKTLRVLLVEDNHTNAFIAQAFCRKYGLDVSWVTDGLQAIEELKIHDYDLVLMDNQLPYLDGVETTRTIKKVLHLPVVVYACTADGLEETRQAFFHAGAEYVLVKPLKEQTLHKALEHFKHHHGQKNAGLN
The following text describes a protein:
Function:
Transcriptional activator which may be required for calcium-dependent dendritic growth and branching in cortical neurons.
Subcellular Localization:
Nucleus. Note=Localizes to nuclear bodies.
Domain:
The MFD (multi-functional domain) domain is involved in transcription transactivation, nuclear body targeting and dimerization.
Sequence:
MSVAFASARPRGKGEVTQQTIQKMLDENHHLIQCIMDYQSKGKTAECTQYQQILHRNLVYLATIADSNQNMQSLLPAPPTQNMNLGPGGMSQTGPSQTLHSQGNLSEALGSSLPPSSIMQGQISNGPNHVSMQQSGQTTLPTTTMSMAVSTHGSAPGYSHTVPSSQNVPMQNQGSIGNYVSRANMNMPSNPVTMMHQQATSSHYTSAQAGSQHYQGQPSIAMMNQSSQGSSMMGQRPLGPYRPSQQGSSQQYLGQEEYYSEQYGHSQGSSEAMTPQYYTDAGHGDYSYQQSSYGEQSYERTFEDSSQHYYEGGNAQYSQQQTGYQQGSGQQQAYSQQQYSNQQNYPGQQQGYVPAQGASSQYSGYQQGQGQQYASYRTSQTTSTAQQQRPYGYEQGQYGNYQQ
The following text describes a protein:
Function:
Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.
Subcellular Localization:
Cytoplasm.
Sequence:
MEAEQQEFAVKQFIDLCNNLGANCSTTTATSPSTSSSSASSTQNLIAVVPPQLQQLQVQLPAPGGGGGAGAGGGGGGGGGAAPVRRHISHTTAVKFLYARKFDIPRAVSLYEQHEQIRLKEYLYNIDPDVEPLRSELQTGKFTILPARTSSGAAIALFTANRHSPLSVSHTTTLQGIVYQLDSALQDSETQRAGLVFIYDMSGSKYSNFDYDLSQKILTLLKGGYPARLKKVLIVTAPLWFKAPFKILRLFVREKLRERVFTVSVPQLALHVPRKALPIHLGGTLEVDHATWLLSCRQSMTNREDELLANIVGVGGGSGSGSAAGSAAIVSTNGTETEAATTAATIISAVHQLGDNNTTVVTVSNGVGPAGSASGGATTAASAATEPNENITINGLSPSHRQAANNSSSSSSSAATVANPLKLNTSGSADNNSTITNATTAAGAAGAAAGTTTNGGGEFWSENPPSSASSGFSDDDSLAGQEGDPKPIDQIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSRGMLQTVDLAGFDEREPDSE
The following text describes a protein:
Function:
Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MADSDAESFASALDDFDDSQVVTPAAEPAAGAPAATATDAATEVGAAKDSANSEEDGVPQAPYPLHRACWNGQTALVRRLAAGLGKEQFKELDGQGNTALHIAVMRRRPACVAALLEAGCPAGPRNARGWVPLMEAVELGDKPLALQLARAEVAQMRQAVKSKKAALLGLLRTQLPDFSLQIKWELGSGMPGVGALVRRYAPHDTYTLWKKGGRIRVDGSLMGVDESSPSLVPGWKRGHFSLLYDASGDKAKSVFVNHTKKTWIDVKAARKKLGVDEGAALEAEVDMLMTSEVLQHKKLKSVDFRFKPVAGWLSKEVREKVEGWNTRLYEAAGRMVAISRYKMPYGLAPTTTFDQYLAATYEPDPVVESAVNPLNPASLKDRGMNPAKAAAKAAVAAKHQRIAAAAAQAEDERAATVAAAAAARAAAGAMRALAPRIDVDEDDDEEDGQGGGEGEGDEELDRAAAELAAAELAEANGNGEKGAKGKKGNGSSSKKKLGTSGSSGFSGMFKMQSAGGAASRKSGGGAATAADGGGTVVHATAAADADGASPSPPPPPPAASPSKQTALSTGGTGAGAGDAAASAAKAMDVDALLKEDLTAWAAQVAADAAKANGGAAADGDGDDEQAAAAAARRSGGGAGPGPGSSSSAAAAAASTVGKTSVSSGGGGSSSSMFGSWGFGKKKEGGGAAPPPAPSTGAGTGTGAGAGGGSGAPAVSAAVVKKSRKITGRCWMAESFPISLNQLLPLLEVVGTANKAFAKVARFMRKYGDLDMFPVKVQIPLLLTVYMMLSFKQFTLLDSSSGSNVGSGVPAAAAAAAAAAAAAASGGKGKGGKDNGGGPHSAPAPDDSFFEIPEGYTQGKLEDESARGMRQGGDGQEEEEGEEEEEEAEGGKSSGDGDGEGGGAKQEKGEAGKGAGDSKAERGGAKDGSDLETVESLRASQFKMKKKKQQQQEEKKKKKKDGGDEGPSLRLLKGTTEDDEMGLGGLDYDD
The following text describes a protein:
Function:
Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDSVFGFKGKDFVCLVADTVFKHSILVLKECADRTVKIHEGQGMIVTGEDGDVLQFTDYIKHSLKLRSLRQGYTPTVKSSANFIRTELARAIREGPYNVYVITGGVDAAGPQLYYMDYLGTMGEDNFCVQGYSMYFLLSVMSEYWKPDMTKQDALDLIKHCIDALGRRFLLQPTKFTASFIYQSLTEKEFINYVPQSIDPTKQQLPNIM
The following text describes a protein:
Function:
Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals. Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A. Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages.
Subcellular Localization:
Cytoplasm.
Sequence:
MATEPRLEEKTFEDETSQDSFQTDQNGNTGGNGLGEDDEAFANDSFIHPGFDRTSIFIEGASDSECGDGKDGSSHGHSDMGDDNSAQGYIHHTISPDQITFSITPGRCNMPDPTNIDHATLTLETECPTTNSKEVKRYRCTYSDCNRSYSTAGNLKTHQKTHTKDYTFVCKQQGCGKAFLTSYSLKIHVRVHTKERPYSCDAADCEKSFNTLYRLKAHQRLHSGETFNCDSDGCTRYFTTRSDLMKHLRTHTGEKPYKCTENSCGKAFAASHHLKTHIRTHTGEKPYSCEKEGCQRAFTTQYSLKSHIKTHAKKGMSSLGCSGEDIQIITTTTGEIAQWSLGSQFVLASSGELGQGDANSLLEQINQQVQAQDSMGLPISTDMLTPIYTDQQGNQIVALGPDTGVAVTTQQPAFVTAGTGGATQVQQSDYSSMGGPVEMLQPSPGQQLPGQQAPLLLPPDLQLQPQTNLIPPTILMNVPVVQSAGEGQPDNSQVFTLKELKMPSAGTSTQPVQDVSSAQVDTQIASLLQHMSQQVQT
The following text describes a protein:
Function:
Binds preferentially DNA with A/T-rich content.
Sequence:
MSAPHHLSYGPKTAVFTNGYGLPTTSYPSPEASYEEITQNPQFFLDKLQTFHSLFGTKFKIPIIGGKSLDLHRLFIEVTSRGGIEKIVSDRRWKEVMAVFKFGPTITNASFVLRKYYLSLLYHFEQVYYFRKKTPSIIPPGRRVVEVGGEVTGTIDNRFEHGYLVSVEMGSEKLSGFLYHIPSEASVGSHGSHNNNMYQYQLALREASPDLEAVDTSGYDVFFTEHYVRLKPLYHGQENVIRKRIQVLWNTLTEEEKQVYQETGSRGKER
The following text describes a protein:
Function:
Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MPSLSLSLSRSLSLSLSLLWQRFSDGQQGAVTPPPQRSAISGLVAGACSGTASVLLLQPLDVLKTQVQTQHNQRYVQLVRNIYQTRGVPGFWKGVMPSLYRTVPGVGLYFATLHTWQKISPLNGHRFHSMLDGALARSLASIALMPFTVIKTRMESNHFQYRSVSHAVIDIWRSQGIRGLYRGTFATVVRDAPYSGLYLQLYRWSTQAIEPWTGTQTMAQSFVGGLMAGLLASLVTQPMDVVKTRLQIDVLAVSTWRTLVNIWQQDGVNGLLRGAVPRIARRACVAAISWTVYERVVLLWGHRT
The following text describes a protein:
Function:
Could reduce the 13-carbonyl of daunorubicin to produce (13S)-13-dihydrodaunorubicin. Could also be able to reduce the 13-carbonyl of doxorubicin (By similarity).
Sequence:
MTVPTPRHGTPHGGLPGRTVLITGATSGIGRAAALAIARQGARVVLVGRDPERLRTVTNEVARTAGPAPDAFRADFAELRQVRELGERLRDRYPRIDVMAGNAGGMFWSRTTTQDGFEATLQVNHLAGFLLARLLRERLAGGRLILTSSDAYTQGRIDPDDLNGDRHRYSAGQAYGTSKQANIMTATEAARRWPDVLTVSYHPGEVRTRIGRGTVASTYFRFNPFLRSAAKGADTLVWLAAAPAEELTTGGYYSDRRLSPVSGPTADAGLAAKLWEASAAAVGDTAR
The following text describes a protein:
Function:
Contributes to floral scent emission.
Subcellular Localization:
Plastid, chloroplast stroma.
Domain:
The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+).
Sequence:
MAFCISYLGAVLPFSLSPRTKFAIFHNTSKHAAYKTCRWNIPRDVGSTPPPSKLHQALCLNAHSTSCMAELPMDYEGKIQGTRHLLHLKDENDPIESLIFVDATQRLGVNHHFQKEIEEILRKSYATMKSPSICKYHTLHDVSLFFCLMRQHGRYVSADVFNNFKGESGRFKEELKRDTRGLVELYEAAQLSFEGERILDEAENFSRQILHGNLASMEDNLRRSVGNKLRYPFHKSIARFTGINYDDDLGGMYEWGKTLRELALMDLQVERSVYQEELLQVSKWWNELGLYKKLTLARNRPFEFYMWSMVILTDYINLSEQRVELTKSVAFIYLIDDIFDVYGTLDELIIFTEAVNKWDYSATDTLPDNMKMCYMTLLDTINGTSQKIYEKYGHNPIDSLKTTWKSLCSAFLVEAKWSASGSLPSANEYLENEKVSSGVYVVLIHLFFLMGLGGTNRGSIELNDTRELMSSIAIIVRIWNDLGCAKNEHQNGKDGSYLDCYKKEHINLTAAQVHEHALELVAIEWKRLNKESFNLNHDSVSSFKQAALNFARMVPLMYSYDNNRRGPVLEEYVKFMLSD
The following text describes a protein:
Function:
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSPTTQAWSINNTVVKENYYTEILSCITTFNTLNFLIVIISVVGMAGNATVLWLLGFHMHRNAFSVYVLNLAGADFLYLCAQTVYSLECVLQFDNSYFYFLLTILMFNYLAGFCMIAAISTERCLSVTWPIWYHCQRPRHTSATVCALFWAFSLLLSLLLGQGCGFLFSKFDYSFCRYCNFIATAFLIVIFMVLFVSSLALLAKIICGSHRIPVTRFYVTIALTVLVFIFFGLPIGICVFLLPWIHMMLSSFFYEMVTLLSCVNSCANPIIYFFVGSIRHHRLQRQTLKLLLQRAMQDTPEEEGGERGPSQKSEDLEVVRCSS
The following text describes a protein:
Function:
Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
Subcellular Localization:
Mitochondrion.
Sequence:
MIRRLFSTLIADYPPAGEFLPSAPSNRQPSTGSGSGGADVVPPAFRTSSLQSLSWLHAISPCFPVSGDRIEVIREPGTFYNTLLDKCSVAQRRIMLASLYLGTGSLETQLVAAIHENLRNNVQLKVDVLLDFTRGTRGERNSKTTLMPLVKETDNFRLSLYHTPVLRGLTKRLAPPRWNELLGIQHMKLYLVDDTVIISGANLSNDYFTNRQDRYVMIEDRRLADFYANFLGKVQEFSLTVGRDGATRLHDTWTMLPYKCAQLEFATEARDRIRAYYRSVMDEQRAVCERDEAQHADTWIFPLIEMGQLGIHHDSLATKQLLSGCLAGSQLRLATGYFNLTETYMNTLTNECQAQCNILMAHPNANGFLGAKGPAGGIPAAYSLLARKFLEMLKSSGQSHRVELLEYERPGWTYHAKGLWYYLPDSSLPNVTLIGSSNFGERSVNRDLEAQICVVTNNATLQRKLETEYQNLLQHATTAETELINRPVPRWVRAVVGLFRNFF
The following text describes a protein:
Function:
Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
Sequence:
MESFPSLTVTQRDQILVEQQVFNIYKAFYDMPPSSQSLMLELQRENHVEYLTNGLKHLGPSFCVLDANRPWLCYWIIHSIALMDEFLDPELEDNTIDFLSRCQDPNGGYGGGPGQMPHVATTYAAVNSLVTLGGDKALCSINREKLYTFLRRMKDPNGAFRMHDDGEIDVRACYTAISVASLLNILDDDLVQDVGNYILSCQTYEGGIAGEPGSEAHGGICQFVACGIASIQYEKASTSSDNLFIRYTFCGLATMILINEVDRLDLSSLIDWVVFRQGVEAGFQGRTNKLVDGCYSFWQGGVFALLKRLQSTKGEQSVPMGDGEDSGAGSPQTTASSDATGAEGLNEDSSQAGSHFEQGEPHDASCPVVVENIDHNSSKRRAKVEPLFNCLALQQYILLCAQEPGGGLRDKPGKSRDHYHTCYCLSGLSVCQHSWSEDEDSPPLPSAILGSYSNLLEPIHPLYNVVLDRYQEAHEFFSRS
The following text describes a protein:
Function:
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The PAL motif is required for normal active site conformation.
Sequence:
MILSSLSVIYINTPSTKAAGEAALSSTYQVFTISDDQSKAASLGLSLVNGLVIVSVIGLMTFLIVILYKFRCMKFLLGYMILATTVLLGFLGSQMFTVAINKYQLPIDKLSFYLTMYNFAIVGTLAVFYQKGVPTIVNQGYLVANSTIVAWQLSYFNDWMAWALLIMLALYDLFAVLTPCGPLKALVNLMSKEDAPAMPGLLYEAELPVNAVRPGRGRRRKWRHQRYSAKTKSRKKRQNTQQSTTSSNNEDEMTQSDNQEQPVIQMMEEVPKECEDDEKGGNTIKLGLGDFIFYSVLVSKAAENGFAAFVACFLSILTGLGGTLVLLAVYHHALPALPISIFLAVVFFVLTIYCMEPWIQDMWQVPYYF
The following text describes a protein:
Function:
Functions as a GC-rich promoter-specific transactivating transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MAQHDFAPAWLNFPTPSSTKLSLNSEKHSENLLWTENRYGANHRRYNSSDGLDPNIGQPNGVHFRRKEKNGWHSQGRNGAENINHHGGYHGRGSRTCTSTLYCGKSQGLYENNVPDNETGKKEYKEVPKQFEAEDFPSLNPEYEREPNQCKPLAAGVWDYSLNPQSSSPRMLVIKKGSTKELQISGFPVVESLHLQTVKNGTGTSVYKGLVPKPATPPTKPTQWKNQENENKLENPFPHEYAYGNFSPFKLTARAFPVSQNLVKESNRSNSSSPIDKVGQLRLTKLTRMRTNKKSKFLKALKQDIVEEDEDENHAGQEKVIFIISVVDPAVTSFRLNVTYVLCGYNQLLRHAGLKPMGWDSTRPNAESCTLATITPGNLQKNGLRKNGILKNGLIYDFKFSPWKNSTFKPSLENEDSETSSSDTSDDDDV
The following text describes a protein:
Function:
Protein-L-histidine N-tele-methyltransferase that specifically monomethylates RPL3, thereby regulating translation elongation. Histidine methylation of RPL3 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus, nucleolus.
Sequence:
MFKFNFDVKAESSEDPEAVKNDIFSKQENSEERESGITKDIDWYNSEKVQPLDNLISAMDFYELNAKEMEVGKMTIKHLVAGFLLEDLKEQSHLVNLDLRKSEENHSDLISGVYEGGAKIWECTEDLLLYLSEKYEDSFWKEKRVLDLGCGCGLLGIYAMKHGARVDFQDYNKDVLEYITYPNILLNLDDSLSEDEKLKFLDNSTTLYSGDWSHFAELSRDVAKYDLILTSETIYNIANQQKLLDTFAGRLKSDGVILVAAKSHYFGVGGGLEQFSENIRLGNVFQSESVWQADENLKRGILQLKFK
The following text describes a protein:
Function:
Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDSLHVSSTSVLVDVVEAVETATSLVVDTAEAVATEQATPTAVISNALARSAYAAHTSLSYLAWAFGLWFLRLIGWVCYGIPTYVLGLLGRTINISLQFSSLLLILIALVTVVVAVVRYKYLTVYSRLPQEQPRQEPEIDMYDESDNEDEKTGFANYFDEFLSAVKIFGYLERPVFHELTRHMQTWKLSADEMVPLDDEQGFSVVVEGTVQVFAKQSSFVQNPTSVPDSRKEDSIMFNGERYTLLSEIKNGAPLTSLFNILSLFTDDLQLHKNFDSAVNSPMTSASDVPNMSLSSDGSDDLQKGEPQFGEPRLSEKPAAKLSVTVRAATDSTIAIIPAAAFRRITKKFPQATAHIVQVILTRFQRVTFQTGHHYFGLTPEIFQTEVNLNSHARNELPGYLREGAVKKLNQVYDASQMGGRPKKYTVTLNKKNKGKGSRRQRFSVQLNNQGHLNSQSRMVSLDSLEAVGDHMNPGDLLTNVPLSRQGRPVFELSSVKHKASIQNLSFSGNDDENEDTALRTALVEAIFKVLGIDRDSIQSSIMAVKTMSNTASPMFTGATTGGSSGSLGEELRSRRTGQDSLGASHFGVGLPSERSQNSFYARSETSTSSVDEDSLMAAPFDTIRNDVAQYMDVVLFKKDSLLIKQDDPTPGLYYLIDGVLEVGYTDHHKIYHDLYTVQPGGVGGYIGSILGHRSFADLRARTDVYAGFLPRAAIERMSDKYPMVHLTMAKSLTKVLSRLLLHLDFAMEWVQVRAGQKIYKEGQEADAIYIVLNGRVRSVAETKGDSGIVGGESGDAKDGKSHRKNLTSIGEYGKGESVGELEVLTLTRRPSTLVAIRDAELAKIPRALFESLALHYPSITFEISRIVASRVRTLMEDSAPIPRRMHTFDMAAHHDSYLTIAVVPISQDVDVSEFGRRLYNGMQAVGREACHLNHASVLNHMGRHAFNPLGKLKLSGFLDDIEDRYQTVLYVADTPPGSSWTHTCISQADCVLLVADARSEPDIGEYERVLVKMRTTARTEMVLIHPERYVPPGLTSAWLKPRVWVHTHHHVQMDLPRHEADVLASIRKMKRTGTLANLKNKVQTIQEEFRSMYRPKANIYSTSSANKDDFNRLARILSGQAIGLVLGGGGARGISHIGIIKALEDSGIPIDFVGGTSIGSFIGGLYAKEYDLVPIYGRAKKFSGRVSSLWRMALDLTYPATSYTTGHEFNRGIWKAFGDSRIEDFWLRYFTNTTNITHSRMEIHTSGYAWRYIRASMSLAGLLPPLTDNGSMLLDGGYVDNLPVSEMKAQGASVVFAVDVGSIDDTTPMNYGDSLSGAWVMWNRWNPFGRHPNVPNLAEIQARLAYVSSVGALEKAKHTPGVIYMRPPIDDFATLDFAKFLDIYRVGNKYGHKFLTELREDGKFPAIPGMENVKTKHKRTIARRNSI
The following text describes a protein:
Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
Subcellular Localization:
Nucleus.
Sequence:
MAAPTGCYKCGLPGHWSRDCSSSSSNPAISTDQRNPNPNIKPWQKTSQLSANSNPSFKQKSPQTVKKAPRQRPKLTEELLLSEDGLGYVLQHFPRAMKIKGPGQEVRDLGNLIELYALWHSRLLPYFSFDQFVKRVEKVGATKRVRMCIRELKERVARGGDPSKLYELPVEPADQNNPPEDIEDSVPDLVEPPVENHEVDVINEEMFDEIYKQAVEEPPCQTSPHSDATINPSIESSEARNVTQGLGLLRLIGSPSYDGLPGSGQLTVILGLGSFGTRDPWSPLRQLQVGLLIF
The following text describes a protein:
Function:
Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MLCRVLSARRVASLLLILLLPYLLQNLRIWLSPRSLVSPANKQSGFFHVEKDENWRLKFQGTANPDVVDDVAEWLGVGKLGEKGLCAPGSFRLATMETCMPWLGCQEMSDEVTVQNMFARGKRKKVYNATWRGHTVAYSNLSNTQYTPHFLRDVEMLRNMQPTSHVVQLVGSCNATLLTQYHRLGSASKIDKIILDRKSNDVRTIFNVAISYIEAIHFLHNSPIGTRVMTDSVQLRHALSQFLVTDDLRLVLNDLDDIPEVNPEENLFIKCRSTRNNSSFIAPEHRRFPLDRPRMSACDEKSDIWKIPPVVDFLLGNVNGSDVVRSHLFEVHQRCQNLDPKQRPSAKVVLKEYKRIRNMLFPE
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSSPAQHLAEPLAQPPAQNLVQSVDWLAIAPPTITAVVGLVVLVTDLFVKDARKPLLGWISVAGLAASALMLLPLVNAERSTFCQAGEPGVCSYTADTFTLAIQCLVLGGALLTALLSVTAVKDADRRLPEGEFWFLLLSSAAGAALLPASRDLATLIVALEVASLPAFALVGLRQGDRRSSEAALKFFLSSVTATAVSLMGISFVYATTGTLYLTQVADRIQHVDGQFTTLAQTGVVLTLVGFAFKTAAVPFHFWVPDTYVGAPLPIAAYLSVIGKAVGFSGLILITVVALPSYADVWGPALAALAALTMTVGNVGALRQQATRAYSAVRLLAWSSVGQAGYLLVPIAAAAYSDDPEHSVGSTVAYALMYAAVNLGAFAVAALVGRTKALNRVADYRGLYASNPLTALLLAFFLLCLAGLPPGIIGLFAKVTVFSAAVDAGLGWLAVVMAVNVVIALFYYLQWTALLFRTPEDATAGHRAPAPLTAAITVTAVLAVALSGAPQLILRFADTGLF
The following text describes a protein:
Function:
Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.
Subcellular Localization:
Endomembrane system. Membrane; Multi-pass membrane protein.
Sequence:
MHKNKPFLGDKKMKSYRNYSENLNIFIKFFSATFGVLAIAGSGALLTHTKVMNKQFTTTLSSLVERLFLPSLIFTNFLKAVTISSLITLIPSIITTFCCLLFGYCIGLFSNKYWIKEKKLNSIVILSSANPHTTNIQLQLSYGLTTYLSKMTEQPEKQIEVKLVTIIIIQTVIVNALRWSIGKTILEQHESDQNQAEIELSDLRIALPEQQTQNKNEPKGEKSFWNMPLLSVLASLCCLVLYPIQDELINDTFLHSAIFLPLQTISKATTPSVLMILGSNLYLIYFNNSSQQEKTSTIIQIVANRLILLPFLGLATILLLDKLSIMTDICQLFILFITFCTPSAINILVMAKQYQQNAEDVVSLILLYGYIGCIITMPIWMIIYLAIFQST