lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation. May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MLYLGWMFLWLVSGERIKGFNISGCSTKKLLWAYSTRSEEEFILFCDLPEPQKSHFCHRSQLSPTQVPDHLPFTDSKDLPDVQWYRQPSNGDPLEDIRKSYPHIIQDKCTLRFLTPGVNNTGSYICRPKMIKSPYDLACCVKMILEVKPQSNASCENSASHKQDLLLGSTGSISCPSLSCQSDAQSPEVTWYKNGKLLSMTRSNRIVVDEVYIYHQGTYVCDYTQSDTASSWTVRAVVQVRTIVGDTKLKPDILDPVESTLEVELGKPLTISCKARFGFERVFNPVMKWYIKDADLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRTFVCFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLVASALLYRHWIEIVLLYRTYQSKDETLGDKKDFDAFVSYAKWSSFPSEATSSLTEEHLALSLFPDVLENKYGYTLCLLERDVAPGGVYAEDIVSVIKRSRRGIFILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWTKMRYHMPVKNSQGFTWSQLRITSRIFQWKGLSTTETTGRSSQPKE
The following text describes a protein:
Function:
Plays a role in DNA damage repair as component of the ASCC complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction.
Subcellular Localization:
Nucleus speckle.
Sequence:
MEVLRPQLVRIGGRIYRKNPIQEQTYQHEEEDEDFYQGFVECAEDPCDAYEVVQTQQGFRCTVKAPSLLYKHIVGKRGDTRKKLEVETKTSISIPKPGQEGEIVITGQHRSGVISARTRIDVLLLTFRRKQPFTHFLAFFLNEAEVQERFLKFQEEVLEKCSMDHGVDSTIFQNPKKLHLTIGMLVLLSEQEIQQTCEMLQQCKEEFIDDISGGKPLEVEMAGIEYMNDDPGMVDVLYAKVHMKDGSNRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNGRYNLYTADGKYIFKERESFDGRNILKLFENFYFGTLKLNSIHISQRFTVDSFGNYASCGQIDFS
The following text describes a protein:
Function:
Catalyzes the hydrolysis of esters.
Sequence:
MSEASSKNLSETLFQNHKQAKETSSLTQYMPSSLELLDTRREQSSQAWYRNLRRLQWIWQGVDPVEQEEILARIASSKHSRTHDEWLDTVMGYRSGNWTYEWTRVGMLHQKQAAERQGEEAADQMFAAALYYSIAGYPHLRNDNLALQAQVLANNAYQEAAKLTGFVVKRLEFSYQNKKIAGYLHLRNTDSPKPVVLVSAGLDSLQTDMWRLFRDYLAKRDIAMLTIDMPSLGASSHWPLTEDSSCLHQAVLNQLADLPWVDHFRIGLIGFRFGGNAMARLAFLESDKVKACVSLGAPIHDIFTSPNKLAAMPKMYLDVLASRLGKNVVDVRSLSGQLMAWSLKVQGFMSGRRTKTPILALGLEGDPVSPYSDNQLVALFSQGGQAKKVKSKTISQGYEQSLDLAINWLEDELCK
The following text describes a protein:
Function:
Could be member of the two-component regulatory system YclK/YclJ. Potentially phosphorylates YclJ.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMKIKYLYQLLLSHISILILAFVIIISLFSHFVKEFAYQNKVEELTSYAVQIANEFQSGQVDMRRLYPYQDILSTRKTQFIIFNEEQQPYFLPEGFHHPPREQLKKSEWNKLKKGQTVTIRADGRFDDEVSLVAQPIFVQNEFKGAVLLISPISGVEQMVNQVNLYMFYAVISTLVITILVSWLLSKFHVKRIQKLREATDKVASGDYDIHLENSYGDEIGVLASDFNIMAKKLKQSRDEIERLEKRRRQFIADVSHELKTPLTTINGLVEGLNSHTIPEDKKDKCFSLISEETKRMLRLVKENLDYEKIRSQQITLNKLDVPLIEVFEIVKEHLQQQAEEKQNKLMIQVEDHVIVHADYDRFIQILVNITKNSIQFTQNGDIWLRGMEGYKETIIEIEDTGIGIPKEDIEHIWERFYKADISRTNTAYGEYGLGLSIVRQLVEMHQGTVEIKSEEGKGTKFIIRLPLTAKQQ
The following text describes a protein:
Function:
The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions.
Subcellular Localization:
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MNTRWQQAGQKVKPGFKLAGKLVLLTALRYGPAGVAGWAIKSVARRPLKMLLAVALEPLLSRAANKLAQRYKR
The following text describes a protein:
Function:
RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (By similarity). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation (By similarity). Binds to beta-actin/ACTB and MYC transcripts (By similarity). Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, P-body. Cytoplasm, Stress granule. Note=Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules.
Domain:
All KH domains contribute binding to target mRNA. Domains KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 also contribute. The KH domains are also required for RNA-dependent homo- and heterooligomerization. The integrity of KH domains seems not to be required for localization to stress granules.
Sequence:
MNKLYIGNLSDHAGPADLESVFKDAKIPVAGPFLVKTGYAFVDCPDEGWALKAIEALSGKMELHGKPMEVEHSVPKRQRIRKLQIRNIPPHLQWEVLDSLLVQYGVVESCEQVNTDSETAVVNVTYSSKDQARQALDKLNGFQLENFTLKVAYIPDETAAQQNPSPQLRGRRGPGQRGSSRQASPGSVSKQKPCDLPLRLLVPTQFVGAIIGKEGATIRNITKQTQSKIDVHRKENTGAAEKSITILSTPEGTSAACKSILEIMHKEAQDIKFTEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQELTLYNPERTITVKGSVETCAKAEEEIMKKIRESYENDIASMNLQAHLIPGLNLNALGLFPPTSGMPPPTSGPPSTLTPPYPQFEQSETETVHLFIPALSVGAIIGKQGQHIKQLSRFAGASIKIAPAEAPDAKVRMVIITGPPEAQFKAQGRIYGKIKEENFVSPKEEVKLEAHIRVPSFAAGRVIGKGGKTVNELQSLSSAEVVVPRDQTPDENDQVVVKITGHFYACQVAQRKIQEILTQVKQHQQQKALQSGPPQSRRK
The following text describes a protein:
Function:
Directs RNA polymerase II nuclear import.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
SMATVIRVKRKRNAEPAEALLLACKRTKLNENFRDDGVTEKIQSAISTRNKLVSMYKPAVAASHPCKVLAGKLATQVKEEPPAKHKYKFISFCKGKEKSEGEKKRRRDSDPVSSSLCSKLFRHRANSSSDEEPKKPKSKKLTALLDVEENLVKNDTPPCDSDILCNTVAMLREKLTINPKKQAEDDFVYDLYYCQNTAKNWNVQDLLYVQPCRDLYLHIDPEWTDPDKLDDDDDSNDEDNWRNDYPDEEDSIDEDERRLLFDEEVDRYDSDDCEPCDYAEDLDNFDDVGFDSFNADAYD
The following text describes a protein:
Function:
Probable protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKDLRLQGPYRKYIPYNIFQQCGIGHLKTLDYIFAFLIVITNFTLIWKSHSSSFWNRPWDNNSEQELSQLIQFYLDKAFYIHELPPFTIQFYSIIRRLKIAENLRYVSLFLNSSTLGFLFLITRRINCSRLISATGLLILSNWETFRNEGTIISFDSLEWCLFSVVIYSFISISIAKLGTTNWFANVITLSISLGLAISSKFIGIVTWAFVILSFVRQFDRLISDVKVTTIQIIKFVILCLLFVLIIPGSIFIISYSNLLSNFKTDTPQFSKYMSTYFKSYLRGPQVQPSRLYYGSTITLRHLDSMVGYLASHDISYPSDVDEQLVALSFEEFAADNEWLIEHPTLNLSFSEVYHADQLIPVEFGQSIKLRHKSTGKLLRASTAKPPISEQDYDFQISCTKDSNYEGGMDERWDVLLIKDEINNDKKDNADDKYIKPLQSEIRFYNNGQRCGLLGHDLRLPEWGRFEQEVLCMEYPVIPRTTFLIDSVQLPVDFQVPMIEYYIGKISSSAEFNHTLSWSQFLYLFKEYIFKQYKYNYYIKYGKNKVTFEDAFAVEKWPITLDTDSPVWFNFAWYGSLLSMIIFMCVQCKRMISWNPWTTAEPSFSIKWEVYNEFGWECIVGWFLHFYIFTMSPHFNLGKKLYFQSFFFSVLCLLESLDCLAK
The following text describes a protein:
Function:
GTPase possibly involved in regulation of the MEK/ERK pathway.
Subcellular Localization:
Nucleus.
Sequence:
MESHLQKRKDSRKPLRIKVISMGNAEVGKQSCIIKRYCEKRFVPKYQATIGIDYGVTKVQIKDREIKVNIFDMAGHPFFYEVRNEFYKDTQGVILVYDVGQKESFESLDAWLAEMKQELGPQINIDNLDNIVFAVCANKIDSTKHRCVDESEGRLWSESKGFLYFETSAQSGEGINEMFQAFYSSIVDLCDNGGKRPVSAINIGFTKEQADSIRRIRNSKDSWDMLGVKPGATRDEVNKAYRKLAVLLHPDKCVAPGSEDAFKAVVNARTALLKNIK
The following text describes a protein:
Function:
May be involved in microtubule organization and stabilization.
Subcellular Localization:
Cleavage furrow. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus.
Sequence:
MENQKEALRKIIKTLAVKNEEIQSFIYSLKQMLLNVEANSAKVQEDLEAEFQSLFSLLEELKEGMLMKIKQDRASRTYELQNQLAACTRALESSEELLETANQTLQAMDSEDFPQAAKQIKDGVTMAPAFRLSLKAKVSDNMSHLMVDFAQERQMLQALKFLPVPSAPVIDLAESLVADNCVTLVWRMPDEDSKIDHYVLEYRRTNFEGPPRLKEDQPWMVIEGIRQTEYTLTGLKFDMKYMNFRVKACNKAVAGEFSEPVTLETPAFMFRLDASTSHQNLRVDDLSVEWDAMGGKVQDIKAREKDGKGRTASPINSPARGTPSPKRMPSGRGGRDRFTAESYTVLGDTLIDGGEHYWEVRYEPDSKAFGVGVAYRSLGRFEQLGKTAASWCLHVNNWLQVSFTAKHANKVKVLDAPVPDCLGVHCDFHQGLLSFYNARTKQVLHTFKTRFTQPLLPAFTVWCGSFQVTTGLQVPSAVRCLQKRGSATSSSNTSLT
The following text describes a protein:
Function:
Quinol dehydrogenase involved in several anaerobic electron transfer pathways. Acquires electrons from the membrane quinone pool and mediates their transfer to several periplasmic terminal reductases and redox shuttles, including the fumarate reductase FccA, the small tetraheme cytochrome (STC), the c-type cytochrome MtrA, the nitrate reductase NapA (either through NapB or directly), the nitrite reductase NrfA and probably also the DmsE subunit of dimethyl sulfoxide (DMSO) reductase. Required for growth on fumarate and on DMSO, and for the reduction of iron(III), manganese(IV), nitrite and nitrate. Not essential for growth on trimethylamine-N-oxide (TMAO).
Miscellaneous:
MISCELLANEOUS: To simplify its purification, a soluble form of CymA was produced by removing the N-terminal membrane anchor. The truncated form is active and can complement the deletion mutant.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Sequence:
MNWRALFKPSAKYSILALLVVGIVIGVVGYFATQQTLHATSTDAFCMSCHSNHSLKNEVLASAHGGGKAGVTVQCQDCHLPHGPVDYLIKKIIVSKDLYGFLTIDGFNTQAWLDENRKEQADKALAYFRGNDSANCQHCHTRIYENQPETMKPMAVRMHTNNFKKDPETRKTCVDCHKGVAHPYPKG
The following text describes a protein:
Function:
Involved in the daf-2/insulin receptor-like transduction pathway, which controls longevity and prevents developmental arrest at the dauer stage. Phosphorylates and activates sgk-1, akt-1 and akt-2.
Subcellular Localization:
Cytoplasm.
Domain:
The PIF-pocket is a small lobe in the catalytic domain required by the enzyme for the binding to the hydrophobic motif of its substrates. It is an allosteric regulatory site that can accommodate small compounds acting as allosteric inhibitors.
Sequence:
MEDLTPTNTSLDTTTTNNDTTSDREAAPTTLNLTPTASESENSLSPVTAEDLIAKSIKEGCPKRTSNDFMFLQSMGEGAYSQVFRCREVATDAMFAVKVLQKSYLNRHQKMDAIIREKNILTYLSQECGGHPFVTQLYTHFHDQARIYFVIGLVENGDLGESLCHFGSFDMLTSKFFASEILTGLQFLHDNKIVHRDMKPDNVLIQKDGHILITDFGSAQAFGGLQLSQEGFTDANQASSRSSDSGSPPPTRFYSDEEVPEENTARRTTFVGTALYVSPEMLADGDVGPQTDIWGLGCILFQCLAGQPPFRAVNQYHLLKRIQELDFSFPEGFPEEASEIIAKILVRDPSTRITSQELMAHKFFENVDWVNIANIKPPVLHAYIPATFGEPEYYSNIGPVEPGLDDRALFRLMNLGNDASASQPSTFRPSNVEHRGDPFVSEIAPRANSEAEKNRAARAQKLEEQRVKNPFHIFTNNSLILKQGYLEKKRGLFARRRMFLLTEGPHLLYIDVPNLVLKGEVPWTPCMQVELKNSGTFFIHTPNRVYYLFDLEKKADEWCKAINDVRKRYSVTIEKTFNSAMRDGTFGSIYGKKKSRKEMMREQKALRRKQEKEEKKALKAEQVSKKLSMQMDKKSP
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Sequence:
MKVDREMEILLNEIPLLHHVGLLGGSEAGADDDADLSFLIHELAAMGLVDGDDELPAPGAATGYGFPTKGENLVAMHSFSMASHYAHMRSLFVPVTFDDAAAADGWDIRCSPPPYVPLPSPATPRARCKSVRRKNGSVMTTSPKKCGAAAAAKWHGESLAGLRGVMYHMARDQHGCRLLQQRLDDGKREVDYIFAGVSRHAAQLMVDPFGNYLMQKLLAVCDDGQRMTLVLTLTADPFALVRISLNVHGTRAVQKLIERLSAREEIGLVMDALRPGFLELIKDTNGNHVVQKCLHSFASNDNKAIFAAAALHCVDIGMQIHGCCVLQRCIARSRGEHRDKLVAAIAHNGFKLAEDAYGNYVVQVVLDLKIPTANSSLAQQFGGKYIHLSMQKFSSNVVEKCLKVFKEVDKAKIILELLATPHLEQLLPHCYANYVVYSALKNSKGSLHSALINAILPHEELLRTSPYCKRIYSKFFLKN
The following text describes a protein:
Function:
Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity). Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments (By similarity). NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity).
Subcellular Localization:
Secreted.
Sequence:
VVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCWNFCQAGKELRAKDLMEKGWNNHKKGKDCSKLGKKC
The following text describes a protein:
Function:
Protein O-fucosyltransferase that specifically catalyzes O-fucosylation of serine or threonine residues in EMI domains of target proteins. Attaches fucose through an O-glycosidic linkage. O-fucosylation of EMI domain-containing proteins may be required for facilitating protein folding and secretion.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MIKSEARLLCLLLLLSCLSLLLYPSLFDPKPGPPQPCPHTPQKNISILLWHWPFGQSYSLKGDKCLTAYNISHCFLTDDTDALPSADVVVFHHQELSRGASALPRHRSAWQRWVWMSLEPPVNNANLRQLNGVFNWTMSYRRDADIPVPYGVTVPGVQRLNVQAATNRSYFACWLVSKYRPSQARAGVYQSLKREIPIEVFGRWKKNPLPDHMLLPTISKCLFYLAFENSEARDYISEKLWRNAFQSGAIPVVLGPSRATYEAVAPPHSFIHVSDFRSTAELATYLKHVAADRQVYEGYLQWHHTHSIKTLTDWRERLCQICARYPSLPASKVYQDLEGWVHS
The following text describes a protein:
Function:
Acetyltransferase implicated in the O-acetylation of Nod factors.
Sequence:
MTEVEKMRSSQLADMSAPELQVRFEHAKKLLAIMRGLSTYDDGYRELLEELVPGIPETSVICPPFHCDHGDGIKLGEHVFVNANCTFLDGGYITIGAHTLVGPCVQIYTPHHPMNYLERRGSKEYAYPVTIGEDCWIGGGAVICPGVTIGNRCVIGAGSVVTKDIPDDSVAVGNPARLIRKQA
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MYNRYIPPPKPAGGAAAPVSSSQPVSQAPAQPARIVFGDDDFVANKQSKTVAEEPIQQVEEPKSKSKKSKKQRDTDDAEEPPRKKTKTDDNDDEQQQQQDEAQPEAATSDTLPIKKEPKKPKREKKKKESVLEKPADLEDDHIRQRHRSVFEKVEKALKLKELQGDEKEDTPEPEEPVYDLGPLPQPAPVVVDSSKLTYETLPPWLANPIRVTTETRKPFTDLGISAEAAKILATKGFKDAFAVQTAALPLLLPNPDLQGDVVVAAPTGSGKTLAYVLPMVQDIALSQTTKLRGVIVLPTRDLVQQVQQACEACAAAFAGSSGGKRVKVGTAMGNRPFKEEQGVIMGTEQEYDLKGYQKWLERQKQLVDLDEDSEQEEEELDLQLKRPLPYHVIQHVPKVDILICTPGRLVEHITKTKGFTLDYVRWLVVDEADKLLAQDFQQWLDVVNEKLAVSKPGARDFAANNKTGPRKVILSATMTRDITLLNGLKLSRPKLVVLEGAKAGDLAIPATLKEYAIKITEPSLKPLYLVDLLQSKYMVPVNGEDVAAGSESSSSSSDSSSDSSSDSDSDSDSEAEPTTRKAKSVSKPTTSKARAAAFPTTALIFTASNQSALRLSRLLSLLLPPSFAPLIGTLTSSTKTSVRLRTLRAFTSGKLRILVASDLVSRGIDLSNLDHVINYDLPLSETSYVHRVGRTARAGREGKAWTLVEFAEARRFWREFVGEGQGAVCNVKRAEGRTVERVRVTEGMDEGGEKKKNGGFSEERVKELEKALEVLRVEATKRG
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 2200 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MPRLTVGTKNMLYPLQKTLAVGSCKPEQVPIRSLASVVESSSKILDKSGSDREVDINVSEKIYKWTKAGIEQGKEHFKVGGNKVYFPKARIILLRPNAKHTPYQAKFIVPKSFNKLDLRDYLYHIYGLRAMNITTQLLHGKFNRMNLQTTRFREPQIKKMTIEMEEPFIWPEEPRPDENSFWDSTTPDNMEKYREERLNCLGSDANKPGTAFDGVVGPYERVAQPFIPRFLKREIDNKRERHAAELQRADKLIALNRYIEDLH
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MTSLEDPNGQAQATYFQESVSTTGNSTPTVTQSNDPQHHHHHQQQQQQHHHHHVGSYYQDSPSSTYTYEVEGDYLENHPNVTSTSAEQGTGTMPTYVDNDNIHGGVGVGMGVETEEEDDDDTNGASIGNGSGSGGGSGGGEQPFYVNAKQYHRILKRRIARAKLEENLKIARTRKPYLHESRHKHAMRRPRGQGGRFLTAAEIAELEKAKQQQQQQQQQQQQQNEQSNQENNNENGNEIKKENQHVDDNNEIKNGDNNINKENIIENNKEEIDPNNVIIKKENNNNEVNHEMNNIENEQSSNEDFNQNNNNNINNNNTTISNNDNENGNTISSSKSNELQESIKNDNNNNNNNNGNDLQEEEER
The following text describes a protein:
Function:
Nucleotidase that shows high phosphatase activity toward non-canonical pyrimidine nucleotides and three canonical nucleoside 5'-monophosphates (UMP, dUMP, and dTMP), and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6-phosphogluconate. Appears to function as a house-cleaning nucleotidase in vivo, since the general nucleotidase activity of YjjG allows it to protect cells against non-canonical pyrimidine derivatives such as 5-fluoro-2'-deoxyuridine, 5-fluorouridine, 5-fluoroorotate, 5-fluorouracil, and 5-aza-2'-deoxycytidine, and prevents the incorporation of potentially mutagenic nucleotides into DNA. Its dUMP phosphatase activity that catalyzes the hydrolysis of dUMP to deoxyuridine is necessary for thymine utilization via the thymine salvage pathway. Is strictly specific to substrates with 5'-phosphates and shows no activity against nucleoside 2'- or 3'-monophosphates.
Subcellular Localization:
Cytoplasm.
Sequence:
MKWDWIFFDADETLFTFDSFTGLQRMFLDYSVTFTAEDFQDYQAVNKPLWVDYQNGAITSLQLQHGRFESWAERLNVEPGKLNEAFINAMAEICTPLPGAVSLLNAIRGNAKIGIITNGFSALQQVRLERTGLRDYFDLLVISEEVGVAKPNKKIFDYALEQAGNPDRSRVLMVGDTAESDILGGINAGLATCWLNAHHREQPEGIAPTWTVSSLHELEQLLCKH
The following text describes a protein:
Function:
Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSTKREDHLRKGADVTPTEALVAGSIAGAISRAFTAPLDTIKIRLQLQPKGFKHRKSVVTIVKNLLENEGIIALWKGNVPAEILYILYGGVQFGSYSIISKSVSKLENNYRINLSSANHSLIVGIGSGIVSTLVTYPFDLLRTRLIANKNRGLLSMTGTIKDIIKLEGIRGIYAGIRPAMLSVSSTTGLMFWSYELARELSNNYQRVPFIEAICGFIAGATSKGITFPLDTLRKRCQMCSVVHGRPYTASHIFVTILKNEGVFGLYKGFGISVLKTAPTSAISLFMYEYSLSFIRKIRVIE
The following text describes a protein:
Function:
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MEKLFCCFPVSMVVEHAEFLKAGKEPGLQIWRVEKFDLVPVPKNLYGDFFTGDAYLVLNTIKQRNGNLQYDLHFWLGNECTQDESGAAAIFTVQMDDYLNGKAIQHREVQGFESATFLGYFKSGIKYKKGGVASGFKHVVPNQVSVQRLFQVKGRRAPRATEVPVSWESFNTGDCFILDLGNDIYQWCGSKSNHFERLKAVQVSKGIRDNERSGRAKVHVLEEGAESQKMLEILGPKPNLPQGPDDTTQVDTANRKLAKLYKVSNSAGAMSVSLVADENPFAQAALKSEDCFILDHGSNKKIFVWKGKQANPEERKAALQTATDFISKMGYPKETQIQILPENGETPLFKQFFKTWQDRDQTQGLGVAYLSSRVANVEKVPFDAATLHTSTAMAAQHGMDDDGSGKKQIWRIENSAKVPVDPSHYGQFYGGDSYIILYNYKHSNKQGQIIYNWQGADSSKDEIAASAILTAQLDEELGGTPVQACTGTRENAQCPLCLPLSDSPMPPTPVPPWEFSVPPICAPPRIPSAPHTWTPPKNPQGHPHLCPLENPAPIIPCSPHQSSPLSHLAFPLPLSTMSQCQTGLGAGPDVQWASKWVMGRRGVAHFLCFSMLHQSRVVQGKEPAHLMSLFGGKPMIVYKGGTSREGGQTAPASTRLFQVRSSSSGATRAVELTPAAGELNSNDAFVLKTPSAAYLWVGQGASEAEKTGAQELLKVLGVKSVSVEEGREPDSFWQALGGKASYRTSPRLKQKMDSHPPRLFACSNKIGRFTIEEVPGELLQEDLATDDVMLLDTWNQIFVWVGKDAEEEEKTEALSSGNFLVSIFTCDPFIRGHLGRERETRSYR
The following text describes a protein:
Function:
Chaperone that specifically binds and folds some, but not all, nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity. Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP. Able to facilitate synaptic transmission in the nervous system probably by activating G(q)-alpha (egl-30). Also able to activate the G(s)-alpha in synaptic signaling network. Plays a key role in asymmetric spindle positioning, a step for asymmetric cell division that generates cell diversity during development by activating G(i)-alpha protein goa-1 and gpa-16 independently of G-protein coupled receptors. While it acts as a GEF for goa-1, it has no GEF activity toward gpa-16. In addition to its GEF activity, it is required for cortical subcellular localization of G-alpha proteins such as gpa-16. Also required for the interaction of goa-1 and gpr-1/2, suggesting that it may act by generating G-alpha proteins free from G-beta-gamma subunits, enabling gpr-1/2 to mediate asymmetric cell division.
Subcellular Localization:
Cytoplasm, cell cortex. Note=Localizes to the cell cortex. Excluded from interphase nuclei and becomes localized around what appeared to be kinetochore microtubules at the onset of mitosis, becoming more diffuse during anaphase.
Sequence:
MSEELHSDLIASIFGGKPAKIEEFFSKWNFANAAVSKFDMANSAKNELGDRICEVIENGELTHVLLETIKILSREKDGLEGLLNDPLCDKILAFAELSSNENNSKTVHTLMEAQKCLINTLFHSQRMRDRFYANPKTGENLQFFLGEFEENRRKTSSIDWIRLLNPVQAAEIWYFYHRIAFIATALGREFQKNWANDPKTIDSLLLAVEICTNRSENSTQDINRATEALKTFFNVFCHFHGDVKAIDHKNAAKTCQILRDAICSDVLTDDVVQSAIHCLSVPPLPMVLSVLCGKNSKNNGGENEEEKFFVEELSNMQLTEAILMHLDKQLTKVVALLLNDAPNQQQNPMLSAEASTLTDLVGPYFQVLARLCTDSKYVRRYCRIRVIPPLVSEEVQKRPEENNTLRGRIARIMMLPSSTKDVAAEFLFIICKRSVNRMIKYLGFGHSAGHLANLGLLGQINQPKHASDSEDSETEDYNQIKDSVNPVTGAIYPSDHGSALAGMSEEQKEYEAMKLVDAMNQMMETGIVKPGTIGDDGKIREVSHVLELLKNAPEPAPAENSDSDEE
The following text describes a protein:
Function:
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.
Subcellular Localization:
Cell projection, cilium membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Sequence:
MASEMEPLLLAWSYFRRRKFQLCADLCTQMLEKSPYDQEPDPELPVSQAVWILKARALTEMVYVDEIDVNQEGIAEMMLDENAIAQVPRPGTSLKLPGTNQMGGPSPAVRPVTQTGRPITGFLRPSTQSGRPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTASMLTSPDGPFINLSRLNLTKYAQKPKLAKALFEYIFHHENDVKTALDLAALSTEHSQFKDWWWKVQIGKCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAKVYISLDQPVTALNLYKQGLDKFPGEVTLLCGIARIYEEMNNISSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEVALRFYRRLLQMGVYNCQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQKSEAAFPDHVDTQHLIKQLKQHFAML
The following text describes a protein:
Function:
Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere.
Sequence:
MSTAGVQQNRPFSRAVRKIKVASTVNSLAKSWQSWANKHSDKQDTIPSGWMPDTIIEDAKEKQKEKNEMKLLVTPRVVSVVGEEATDDQIKTGIVTKAITPKCNEFGKDLVSVIKEKINTNQLTTEDTKNFLGNESPTRRRYCGGKAGTFVKAIGRKEGKSMGSRSSSLDADDSGLGEEASLSDNSDLNENEPKKHVNRHKIKVTTMGDLRSRWQRFAEDHMEGQKLNPFSEEFDYDHAMATRLHKGDAGYGRPKEGSKTAQRADRAQKHIYREMEEMCFIIRDMGQQDKQGQIWVTFGRLFDRYVKISDKVVGILLRCRKHKMVDFEGEMLWKGQDDDVIITLLV