lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication (By similarity). Binds ds- and ssDNA. Binds the antibiotic griselimycin and its derivatives with high affinity (1.0 x 10(-10) to 2.0 x 10(-10) M sec(-1)). Binding occurs in a hydrophobic cleft between domains 2 and 3, which have been shown to be responsible for binding DNA polymerases and other DNA-modifying proteins.
Miscellaneous:
MISCELLANEOUS: Strains that are resistant to griselimycin occur at a very low frequency and are associated with amplification of a 10.3 kb chromosomal segment containing this gene as well as the ori site, suggesting antibiotic resistance may be due to overexpression of the wild-type protein.
Subcellular Localization:
Cytoplasm.
Sequence:
MDAATTRVGLTDLTFRLLRESFADAVSWVAKNLPARPAVPVLSGVLLTGSDNGLTISGFDYEVSAEAQVGAEIVSPGSVLVSGRLLSDITRALPNKPVDVHVEGNRVALTCGNARFSLPTMPVEDYPTLPTLPEETGLLPAELFAEAISQVAIAAGRDDTLPMLTGIRVEILGETVVLAATDRFRLAVRELKWSASSPDIEAAVLVPAKTLAEAAKAGIGGSDVRLSLGTGPGVGKDGLLGISGNGKRSTTRLLDAEFPKFRQLLPTEHTAVATMDVAELIEAIKLVALVADRGAQVRMEFADGSVRLSAGADDVGRAEEDLVVDYAGEPLTIAFNPTYLTDGLSSLRSERVSFGFTTAGKPALLRPVSGDDRPVAGLNGNGPFPAVSTDYVYLLMPVRLPG
The following text describes a protein:
Function:
Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
Sequence:
MHEMALCEGIIGIVEEEARKRAFAKVNVVCLEIGALSHVAPEALQFCFEAVAARTIAQGAKLEIVETPGTAWCMACSKSVEIKQRYEPCPSCGGYQLQVTGGEEMRVRELEVD
The following text describes a protein:
Function:
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons as well as basal forebrain cholinergic neurons in the brain. Its relevance in the snake venom is not clear. However, it has been shown to inhibit metalloproteinase-dependent proteolysis of platelet glycoprotein Ib alpha, suggesting a metalloproteinase inhibition to prevent metalloprotease autodigestion and/or protection against prey proteases (By similarity). Binds a lipid between the two protein chains in the homodimer. The lipid-bound form promotes histamine relase from mouse mast cells, contrary to the lipid-free form (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MSMLCYTLIIAFLIGIWAAPQSEDNVPLGSPATSDLSDTSCAQTHEGLKTSRNTDQRHPAPKKVDDQEPGSVANIIVDPKLFQKRQFQSSRVLFSTQPPPLSRDEQSVEFLNNEDALNRNIQAKRQNHPVHDLGEHSVCDSISEWVTKTTATDIKGNTVTVEVDVNLNNEVYKQYFFETKCRNPNPVPSGCRGIDSRLWNSYCTTTQTFVKALTMEGNQASWRFIRIDTACVCVITKKTDNL
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MNDADTNLGSSFSDDTHSVFEFPELDLSDEWMDDDLVSAVSGMNQSYGYQTSDVAGALFSGSSSCFSHPESPSTKTYVAATATASADNQNKKEKKKIKGRVAFKTRSEVEVLDDGFKWRKYGKKMVKNSPHPRNYYKCSVDGCPVKKRVERDRDDPSFVITTYEGSHNHSSMN
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Subcellular Localization:
Cytoplasm.
Sequence:
MAQAPGVNGLCGGTPASCSSACDRHGEEARGMSANGASVRVTGDTSDGGGGGSGETAAREGAPAAPLCVKCRAAPAEVIANQREPYCGACLRASLLYKVKTAINKHALVQAHDAVLLAFSGGHSSTVLLHFLSELQSHATTPLAAAADRGKTVFRLGLVFVSEAAVLSRPHYDGDADVERIRKLAAPFEKRGCRVHVVRLEELFLKGRSQAHQAAPEGTMPRGSQDSATKGVVRNDSGDQLEEGRPGYSVPHTDGLAGAWERLRAMVARVADATAQEDLVEMLRTEALQQVAVEHGYTKIATGVCASRLAAEVLTGTVKGRGFSLPADLQAVDRRRTVPVIAPLRDCVIKELATLCTLNRWPTTFVPSLDAGPTARPSLNRLTQDFLTLIEDDLPGRTLTILRTAGKLQPFPFNAFPALPPGHRARLQPAQGTEAAAEPADGVNLCALCRAPLTSAEVQDGGAGERGARGPESEPGQRLGADAGDGGNEGRDTAEQARAEQAEERRGAAAPAGDQLRENGAEVGSTGGESDGRGVEVASVGHEASNGDSRGSSGAGRGVVPPGPQSEARPGGVACCRSCREQVLGGTGGTANPAWLHDLPWLDRAGGRAAEEARRDRMRNKIQDFLL
The following text describes a protein:
Function:
Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MSKGFEVYPLTGSHKEVVINEALIRSAISFKPSLTTEDDRVRVVGNQEKALCEEKVQKEAAGIALEDVQTLLLSFRGIKRLENLSCLRSLTKLHLDNNRIRCIEHLESLVHLEWLDLSYNAIEVIDGLQALQHLNCLSLYANKITAVDGLTCLPELNTLSLGRNPLENIDETVHYLHHLPRLQVLTLKECPLAGLPNYRSRVLAFVRGLKFFDGHLVRHDEAAKAREAFRENLLTVDEEDEARAAAAKLQADQEIIASSYQQYNCPNEVMLFDELLHLDPEGRHMEAILRSEAVFSVAKEPLDRYQTEFNEQLRQLTAAMKDIRERRDADDAAYREAVTYTLRHSAAASLASMQRFEALAKGHIVKGVAQPVPGPAKRLPSQATRSLHAALDKLKKDLLEEEAHQYDVLEVLHNNTIAKWKSHSVEVVLQSSFEALLRLETDFQATVRHIFDAVFEERRKGDNAERAFRYVGQDDAMLAFLDNKEEYQRTVNEWYELRRKRVEELEMHHLKAEETLLNARANSILAAEQDRHRRRVHEVCQYVKEMSSRIDGCDH
The following text describes a protein:
Function:
Essential for mitochondrial protein synthesis and required for the maturation of small ribosomal subunits; Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. uS3m is essential for mitochondrial protein synthesis and required for the maturation of small ribosomal subunits.
Subcellular Localization:
Mitochondrion.
Sequence:
MQKNNLKNLITTIVTNAFFNQKANFSIPLKGVIGEKRPSILIGNININFKSDSLIEVSFPYYPLLNKNYPNPSIISNIIQKALSNHLLYSSKNYSFIVNIRALPISTPYGSSLIFSKYIAIIIGSNPKIASTLWIDPKRFINLPKLQSDSIFKILGLNVPKGWKGIHISLNLIKWNSLSSRGRITNIIKGSVPLTNNSNGYDESSLAIYSKMGTIQIKVRLSYSSNL
The following text describes a protein:
Function:
Probable transcription factor. Involved in modulation of cellular senescence; represses transcription of the tumor suppressor gene INK4A/ARF, perhaps acting via the Polycomb group (PcG) complex PRC1.
Subcellular Localization:
Nucleus. Cytoplasm. Nucleus, nucleolus. Chromosome. Note=Probably localized to nucleolus and cytoplasm in complex with 40S ribosomal protein S2/RPS2.
Sequence:
MAASEVQGLPVDPREAGVRGVRGGIGHTDHEGHLGSFQLLATINKAAMNIVEHVSFLPVGTSSGYIAASSGITMSNFLRNRQTDFQSGCTSLQSHQQWRSVPLSPHPHQHLLSPEFLILAILTGVRWNLRIALICISLMIKDAEHFFRCFSAIWYSSDSKDCILEPLSLPESPGGTTALEGSPSVPCIFCEEHFPMAEQDKLLKHMIIEHKIVIADVKLVADFRRYILYWRKRFTEQPITDFCSVIRINSTAPFEEQDNYYLLCDALPEDRILREELQKHKLKEVLDQQQRERNDTSFHGVCMFCSEEFRGNRSVLLNHMAREHAFNIGLPDNIVNCAEFLCTLQKKLDNLQCLYCEKTFRDKNTLKDHMRKKQHRRINPKNREYDRFYVINYLELGKSWEEVQSEDDRELLDLQEDDWSDWQEYPVSAVCLFCEKQEETIDKLYVHMKDTHEFDLLRIKSELGLNFYQQVKLVNFIRRQVHQCKCYSCHVKFKSKADLRTHMEDTKHTSLLPDRKTWDQLEYYFPTYENDTLLCTLSDSESDLTAQEQTENVPVISEDTSRLCALKQSSVLNQLLLQGCLEN
The following text describes a protein:
Function:
Required for ubiquinone (coenzyme Q) biosynthesis. Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex. May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSLLIQAVLAAAETGINRVLRLDGTALPRLRRLSAKVIEVDCLSPPLRVFILPAGDGLHFAAQHEAEVDCTLRAPAGNLLHLALARDKTRILHSPEVSMDGDSAALLELAGILQSLELDWEYELSRWLGPLATQVLGSSLRDASRWSAQSLHSLRLNLADYLAEESRTLVGQHEAEARFAELDQLKLALDRLDARVGRLSQKTKPDA
The following text describes a protein:
Function:
Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Involved in the integration of FimH in the fimbriae.
Subcellular Localization:
Fimbrium.
Sequence:
MRNKPFYLLCAFLWLAVSHALAADSTITIRGYVRDNGCSVAAESTNFTVDLMENAAKQFNNIGATTPVVPFRILLSPCGNAVSAVKVGFTGVADSHNANLLALENTVSAASGLGIQLLNEQQNQIPLNAPSSALSWTTLTPGKPNTLNFYARLMATQVPVTAGHINATATFTLEYQ
The following text describes a protein:
Function:
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
Sequence:
MVMILVGGMQGGTMVSLASAASVVSAGTSANRGSSEVPYSPVRKIAFPRGKHWSSVKRWHCKYSVTTTDFIAEHTNAVSLDSNNGYGGDKDDDNEILLKPAPRPVVKPSDAKTNSVGLEPSRPSRDSSVETLDGLENKNNVLESLDEVLEKAEKLEKSNLGRQASKKEGGNVNKSTPSGTSANPRNGVWRKGDNVAAVQKVKFPMDSPDSNKVIDDPESQKVEEHDEPRASLRPAQPPLRLQPKLQAKPSVAPPPALKKPVILKDVGAAPKSSTVDDEANLIDKFATKKPVVDPLIAQAVLAPTKPSKGPASGKFKDDYRKKNASAGGPRRRMVNDDIEIPDEEASELNVSIPGAASARKGRKWSKASRKAARLQAAKEAAPVKVEILEVGEQVMLIEDLAYNLATSEGEILGLLYSKGIKPDGVQTLDKEMLKMVCKEYEVEVIEADPIKVEEMARKKEIFDEDDLDKLEDRPPVLTIMGHVDHGKTTLLDYIRKSKVAASEARGIMQGIGAYKVLVPVDGKLQPCVFLDTPGHEVILLHILTSLQFGAMRARGARVTDIAIIVVAADDGIRPQTSEAIAHAKAAGVPIVIAINKIDKDGASPEWVMQEPSSVGLMPEDRGGDIPMVQVHLFLWMGSVFSSCCASSWCLTVLCAILRISALKGENVDDLLETVMLVAELQELKANPHRNAKGTVIEAGLHKSKGSTATFIVQNGTLKRGDVVVCGGAFGKVRALFDENGKQVLEAGPSIPVQVIGLNNIPIAGDEFEVVGSLDTAREKAEARVESLRNERISAKAGDVKVTLSSLASAVSSGKLSGLDLHQLNIIMKVDVQAPGSVKSYADNKGVEIRLYRVIYELIDDVRNAMEGLLESVEEQEMIGSAEVRAIFSSGSGRVAGCMVTEGKVVKGCGIRVVRKGKTAYVGILDSLRRVKEIVKEVGTGLECGIGMEDYDDWEEGDIVEAFNTVEKRRTLEEASASMTAALEDVGIKL
The following text describes a protein:
Function:
Functions as a negative regulator of mitosis. It interacts with the C-terminal of nim1, thereby inhibiting its kinase activity which phosphorylates wee1.
Subcellular Localization:
Cytoplasm.
Sequence:
METMQSRTYAGLTKLNTTTALLNKKDGNDDDKAEHSKRSGYHGLSPLDALALKHRDLNRKLNLRAMMSKSEDNLQILKETTSGSSSDLLNIESPASPAEASSPFTVRTPTVHDPEHYFVAQKLSSVFGTPDLEDETDFFDYFSAAPDVHPNDIFDSYNSNNIAESFDDDNYYNSLLPPNAPYYHEIEPPRTASNTSPTPNSIKSAHPAEPPKRPAFTRSATSPDKILPTRIKSKDTVSSGDSTPLSGSSSSKGMLMSMSTSENHSLSSNPELSNSNLLAKNESPADVSNNESGNESSKEPDKEHSTPIHPTTPVSRCARPSSRQQTISILQAQSPFLKKSDKERANLNKTMVSINKSINIHQSIHEISCPHHSSSDNCLFILISLMDRLHSPVLKQLDVSLQSLTMTAIRYIDLNYVDVQYTNLRGGAYGNGNNSESSDNAQLKKEEHLNLAIHFHLLNDHDKCFWHTGMASSYEDYTATFIYGLYLRHGLACSPKTHVSFLFLLKTATQLLNKLVECLHSSDLGLNDTTPNEKLSTEYNQQRLLLALILYELGVCFMHGWGITRDRYLALHLIKLSGAWGDADAQFEAGLQMSLGAVSDKDSHMAAYYYRLAGFQGISPPSKCKWVYKSKYSLAANHKVPAASEVAYVSAIVENLESHSLKFSTKPKAKLRSLITSVRYL
The following text describes a protein:
Function:
Has a role in regulating chromatin structure via global deacetylation of histone H3. This function is associated with the activity of a histone deacetylase.
Subcellular Localization:
Nucleus. Note=Associates with chromatin.
Sequence:
MRKNSSHENQSSENIIEFPYVDFEELNVHSNIFSELEHAKPSTQQQQQQQNISNETTSTGPRICISRDEFKAVNLLTKEEINVRVTPKKEEFSRGLDFISDLYDQTARKSGAVRVIPPDNWKCPLTINTTTFKFLTRKNNPSSMSLVSNYPLDAISSQQKFHGNDKTLEKNSAKATINKSNSTAETSSTATVEPYDSNDLYRIFDRPDAVVLSYIFVLGKAVDLLQIKQWLQLSKQKNLLEFEFWSQAAQHYKLDVNSLRNAYNLYAETGVTTRTGNDGGSPINRPAKRVKRQNHIPKCKLCAQEGSSLVTCCICQSNYHYACVEAPFAPFSDIHYWTCNSCIPSSLKILWKEVDYHCISSFLQSSNELASSLKKQLPSFLAQTPLTLPSNTKTPPASARQSSRRTRSTSGKGFETKISINLDSDIKLLNTLSPLETFFWCCSFPSTASTSSPFSYYPESLPTPLLGRAVNTTAFPTSRQNAYYNDPWNLYFIHFSKLSPLRFTPPGILTSTISLGQPLTCQGWQRDSMSLFGMHYHHYGAQRIWYVIPEVDGPKYEKLLNDLSPSFIQEKPETLIKSKILLPISMLISNGIQVLTFVQNSNEFVITSPNTYYTVLDTGFSLSESVPFATKEWIQDMHAENSFNMYKNLHISAPFSLDHILLANATLDKTVHSAYWLMTCLKDRVDRELTLRNEFRKRHPLLTWIPTPLESSVMACAFCKTFAYLASIEEKNGTKTACLSHKDECFPNTDSDLTVLVRYDDNALLAAYSKVVERAHKADTWLENYKEALGSDNSRPSLKVLKTLLNEAETICCPLQEVSLVRNLVKTAQQWLDKFAIIFKKKSMVKKEKRKPKRGSATHSHLESPSEEVEDLNSSNINEADLLINLVEEAEQFTFDFPEMAVAFEKAESLKIFREKANAMKERSLSYEECLAIVEEGESLQLKTPELLYFKQYMEKTEWIDSFNQISQKTDSTMEELVELIERGEKIGLTSDNENMATALLLKEKSENWMKQVEGLLSQETLSTSKLFQLKSEANSICINRGLLEQLNEVLQKSENFHTQLVSLISRARDPDYYSRPTIEEAKTVLAESENLTNKPEEYTVAQKLLTQTYEWVRRGKRLFGKANAPLEIFNQHLEFVEQRNTNAMVDEGSDAPFHVGNEYYVIAGSDPSDFHYCFCRQPEAGMMIECELCHEWYHAKCMKMSKKKLRADEKFICPICDYRVEVPRHSHRPPLIELQKMVDDIPTLPFQPIEIELLKRVVKQAEEFKNKMQSEVCDPTQLSEKDVPLLQFYLRKLEGSEILFTEELNVFRQKLHEFMPVAPQPPPFIGESRSNRKPRPTKRQREIMEQVESGKLTSAEGAAAIAATQTRNQNNFISKPFNVHTLSTTLSPWAMKSLAQAAISPNPMPSAHDLLPTSNPAELFTNISPEIKELSVDSTSTLGGLNSSHLVSDQNASVICLCRQPFAISDGTVQCHNCLEWFHYECVGLSSDIVSTLSNYACPDCCSKEGKLYPWNTRPRSTPSVWLSQAYSPSVLQGTTENVAFLNKAFSASANLFDVLPVSNTPSHFSKMDYVLEDRKPDLFTETYLSM
The following text describes a protein:
Function:
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
Sequence:
MINPELPSICLIVSSKEIPEKLEIALKAGIKWIQYREKELPRKEILKYAFWVKEITKHYNALLTINDYLDIAITIKADGIHLGQNDLPIEVAKKFFSGIIGISTHNLEEALDAQKKGAHYIGYGPIFYTTTKKDALEPKGYDMLSLICKKIKVPVVAIGGIKKQHLKDLKAMGCKYVAIASGILVGDVKSNVKDFLELFQ
The following text describes a protein:
Function:
Protein involved in the remodeling of chromatin thereby regulating various processes including transcription, chromosome synapsis and genome integrity. Mainly binds genomic loci carrying trimethylated histone H3 'Lys-36' (H3K36me3) or 'Lys-4' (H3K4me3), and acetylated histone H3 'Lys-9' (H3K9ac), 'Lys-27' (H3K27ac). During meiosis, required for the presynaptic pairing of homologous chromosomal regions outside of the pairing center and for the progression of chromosome synapsis. Essential maternal factor required in postembryonic germline development and in maintaining germ cell identity. Plays an important role in maintaining genomic integrity in primordial germ cells (PGCs) during meiosis by regulating DNA double-strand break (DSB) repair and synapsis. Also, required for chromatin-based transcriptional silencing in PGCs and for silencing of X-linked genes in the maternal germ line. By retaining histone acetyltransferase, cbp-1, in euchromatin, promotes the anchoring of heterochromatin at the inner nuclear membrane in intestinal and hypodermal cells.
Subcellular Localization:
Nucleus. Chromosome. Note=Concentrated on euchromatic regions marked by H3K36me2/me3 and probably enriched on autosomes.
Sequence:
MSSKKNFEVGENVACIYKGKPYDAKITDIKTNSDGKELYCVHFKGWNNRYDEKIPVGEEKDRIFKGTASEYAEKHNAELPTTALKPKKKSLAAEAPRDDRDDTPGTSKGKKAKSVTIAPVMTADDMKVELPKPLRKILIDDYDLVCRYFINIVPHEYSVDQIIEDYIKTIPVSNEQMRTVDDLLIEYEEADIKITNLALICTARGLVDYFNVTLGSSYQLLYKFERPQYNDLVKKRAMEKGIDITNPTALQDSGFRPSQEYGIVHFLRMLAKLPDYLKLTQWNDHVINRIMIGVHDLIVFLNKNHGKYYRGSSDYQGASNDYYRRSLAADDGVGANQ
The following text describes a protein:
Function:
Acyltransferase required for the fatty acid remodeling of phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI). Mediates the conversion of lysophosphatidylinositol (2-acylglycerophosphatidylinositol or LPI) into PI (LPIAT activity). Has preference for saturated and mono-unsaturated fatty acids as acyl donors and sn-2-acyl lysoPI (2-acyl-sn-glycero-3-phospho-D-myo-inositol) as acyl acceptor. Contributes to the asymmetric cell division of epithelial cells. Asymmetric cell division is the fundamental mechanism by which multicellular organisms generate cell diversity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MRIPCLLRPLLGWFFGLCILFSALFGNYIITLFLGLPILGRHKQWRNLMDRAISYWMTIPMGLLEFLMGVRIRVSGDEIEFGSPAMIVMNHRTRLDWMYMWCALYQINPWLITSNKISLKAQLKKLPGAGFGMAAAQFVFLERNAEVDKRSFDDAIDYFKNIDKKYQILLFPEGTDKSEWTTLKSREFAKKNGLRHLDYVLYPRTTGFLHLLNKMREQEYVEYIYDITIAYPYNIVQSEIDLVLKGASPREVHFHIRKIPISQVPLNEQDASRWLTDRWTIKEQLLHDFYSEEQPINRQFPVERGDGVWRSWKEPRRHFYVKLTSLMFWTLVISFCSYHIFFVRTLQLGFLYFFVISFYLSWRYGGIDKYIIFKWQESRKSLQKSPSSSSI
The following text describes a protein:
Function:
Catalyzes endohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan with retention of the beta-configuration of the glycosyl residues in xyloglucan degradation. Cleaves the backbone of the 3 major types of natural xyloglucans (seed galactoxyloglucan from tamarind kernel, dicot fucogalactoxyloglucan from lettuce leaves, and solanaceous arabinogalactoxyloglucan from tomato fruit), to produce xyloglucan oligosaccharides.
Miscellaneous:
MISCELLANEOUS: Gut bacteria supply the human body with energy from dietary polysaccharides through glycosidases that are absent in the human genome. Xyloglucans are a ubiquitous family of highly branched plant cell wall polysaccharides present in the vegetables we consume. Enzymes involved in xyloglucan degradation mediate the conversion of otherwise indigestible plant polysaccharides to short-chain fatty acids.
Subcellular Localization:
Cell outer membrane; Lipid-anchor. Note=Cell outer membrane localization is predicted by analogy with the archetypal sus locus.
Domain:
The BACON domain was initially thought to act as a carbohydrate-binding domain. However, it does not bind carbohydrates and may rather be required to distance the catalytic module from the cell surface and confer additional mobility to the catalytic domain for attack of the polysaccharide.
Sequence:
MEKQSFSDGLFSPLGIKRVIFMLVLLTTSFISCSNSDEKGGSLEVAQEYRNLEFDARGSRQTIQIDGPAEWHISTSESWCKSSHTIGEGKQYVNITVEANDTQKERTATVTVSASGAPDIIINVKQSLYSVPAYDEYIAPDNTGMRDLTSMQLSALMKAGVNVGNTFEAVIVGNDGSLSGDETCWGNPTPNKVLFEGIKAAGFDVVRIPVAYSHQFEDAATYKIKSAWMDKVEAAVKAALDAGLYVIINIHWEGGWLNHPVDANKEALDERLEAMWKQIALRFRDYDDRLLFAGTNEVNNDDANGAQPTEENYRVQNGFNQVFVNTVRATGGRNHYRHLIVQAYNTDVAKAVAHFTMPLDIVQNRIFLECHYYDPYDFTIMPNDENFKSQWGAAFAGGDVSATGQEGDIEATLSSLNVFINNNVPVIIGEYGPTLRDQLTGEALENHLKSRNDYIEYVVKTCVKNKLVPLYWDAGYTEKLFDRTTGQPHNAASIAAIMKGLN
The following text describes a protein:
Function:
Plays a role in processing non linear or branched viral DNA intermediates in order to promote the production of mature packaged unit-length linear progeny viral DNA molecules. Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single-stranded DNA as substrate. Exonuclease digestion of DNA is in the 5'-> 3' direction and the products are 5'-monophosphate nucleosides. Additionally, forms a recombinase with the major DNA-binding protein, which displays strand exchange activity. Also acts as a cytoplasmic RNA endonuclease that induces degradation of the majority of the cellular messenger RNAs during early lytic infection. The resulting inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and evasion from host immune response. Internally cleaves host mRNAs which are then degraded by the cellular exonuclease XRN1. Bypasses therefore the regulatory steps of deadenylation and decapping normally required for XRN1 activation.
Subcellular Localization:
Host nucleus. Host cytoplasm.
Sequence:
MADVDELEDPMEEMTSYTFARFLRSPETEAFVRNLDRPPQMPAMRFVYLYCLCKQIQEFSGETGFCDFVSSLVQENDSKDGPSLKSIYWGLQEATDEQRTVLCSYVESMTRGQSENLMWDILRNGIISSSKLLSTIKNGPTKVFEPAPISTNHYFGGPVAFGLRCEDTVKDIVCKLICGDASANRQFGFMISPTDGIFGVSLDLCVNVESQGDFILFTDRSCIYEIKCRFKYLFSKSEFDPIYPSYTALYKRPCKRSFIRFINSIARPTVEYVPDGRLPSEGDYLLTQDEAWNLKDVRKRKLGPGHDLVADSLAANRGVESMLYVMTDPSENAGRIGIKDRVPVNIFINPRHNYFYQVLLQYKIVGDYVRHSGGGKPGRDCSPRVNIVTAFFRKRSPLDPATCTLGSDLLLDASVEIPVAVLVTPVVLPDSVIRKTLSTAAGSWKAYADNTFDTAPWVPSGLFADDESTP
The following text describes a protein:
Function:
Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole (cvt). Involved in the formation of nucleus-vacuole junctions (NVJs) during piecemeal microautophagy of the nucleus (PMN). NVJs are interorganelle interfaces mediated by NVJ1 in the nuclear envelope and VAC8 on the vacuole membrane. Together, NVJ1 and VAC8 form Velcro-like patches through which teardrop-like portions of the nucleus are pinched off into the vacuolar lumen and degraded by the PMN process.
Miscellaneous:
MISCELLANEOUS: Present with 5680 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole membrane; Lipid-anchor. Note=Localizes at sites of nucleus-vacuole junctions.
Domain:
Comprises a flexibly connected N-terminal H1 helix followed by armadillo repeats (ARMs) that form a right-handed superhelical structure; the H1 helix directly interacts with ARM1 and hinders the dimeric interface. ARM1 serves as a binding interface for the formation of the 2-fold dimer of VAC8, which is crucial for heterotetramer formation with either NVJ1 or ATG13 and subsequent PMN and Cvt pathways; The highly conserved innergroove formed by the ARMs specifically binds the extended 80 Angstroms-longloop of NVJ1. The ARMs domain also binds the he 70 Angstroms extended loop of ATG13 in an antiparallel manner.
Sequence:
MGSCCSCLKDSSDEASVSPIADNEREAVTLLLGYLEDKDQLDFYSGGPLKALTTLVYSDNLNLQRSAALAFAEITEKYVRQVSREVLEPILILLQSQDPQIQVAACAALGNLAVNNENKLLIVEMGGLEPLINQMMGDNVEVQCNAVGCITNLATRDDNKHKIATSGALIPLTKLAKSKHIRVQRNATGALLNMTHSEENRKELVNAGAVPVLVSLLSSTDPDVQYYCTTALSNIAVDEANRKKLAQTEPRLVSKLVSLMDSPSSRVKCQATLALRNLASDTSYQLEIVRAGGLPHLVKLIQSDSIPLVLASVACIRNISIHPLNEGLIVDAGFLKPLVRLLDYKDSEEIQCHAVSTLRNLAASSEKNRKEFFESGAVEKCKELALDSPVSVQSEISACFAILALADVSKLDLLEANILDALIPMTFSQNQEVSGNAAAALANLCSRVNNYTKIIEAWDRPNEGIRGFLIRFLKSDYATFEHIALWTILQLLESHNDKVEDLVKNDDDIINGVRKMADVTFERLQRSGIDVKNPGSNNNPSSNDNNSNNNDTGSEHQPVEDASLELYNITQQILQFLH
The following text describes a protein:
Function:
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.
Subcellular Localization:
Cytoplasmic granule. Nucleus.
Sequence:
MVDSQRNVIQPLDLAWVESSRVNLPAVQRRAATHLKRRSVKKDWQAAWFLRAVTCLDLTTLSGDDTETNVSRLCFKANNPIRQDVLESLQLKDLKITTGAVCVYSSRVKDAVTANKNNHSQVPIASVAAGFPDGQTPLPQRLDEIKYAVEAGASEIDIVITRSYVLSGNWQALYDEVAACKKACGNALLKTIIATGHLGTLTNVYKASLVSMMAGSTFIKTSTGKEAVNATFPVALVMIRAIRDFYQRTGYKVGFKPAGGIRSAKDCLSWLALMKEELGDEWTQPNLFRIGASSLLGDIERQLYHFQTGRYAALYQFPMS
The following text describes a protein:
Function:
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MARSSIEQLTSFLRSVNGRAKKALSQNFLVDGNILRKILTTAEVQPGDWVLEIGPGFGALSEVLLSQGANVIALEKDPMFEESLSQLPMDIEITDACKYPLTSLEDKGWKGKGRIVANLPYHITTPLLTKFFLECPYRWKTVTVMIQDEVARRITAKPGDKDYGSLTVFLSFFADVQYAFKVSPNCFYPKPSVHSAVVHMRVHEQFALADSEIEEFFTLTRAAFGQRRKLLANSLKNLYPKDKVFQVLEQLGFSEKTRPETIFLEEYLKIFHLLKDI
The following text describes a protein:
Function:
Involved in response to drought stress.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing LEA19 display enhanced drought resistance under field conditions.
Sequence:
MASHQDQASYRAGETKAHTEEKAGQVMGASKDKASEAKDRASEAAGHAAGKGQDTKEATKEKAQAAKERASETAQAAKDKTSGTAQAARDKAAESKDQTGGFLGEKTEQAKQKAAETAGAAKQKTAETAQYTKDSAIAGKDKTGSVLQQASEQVKSTVVGAKDAVMSTLGMTEDKAGTDDGANKDTSATAAATETTARDH
The following text describes a protein:
Function:
Could possibly oxidize fatty acids using specific components.
Sequence:
MRRRAMTKMDEASNPCGGDIEAEMCQLMREQPPAEGVVDRVALQRHRNVALITLSHPQAQNALNLASWRRLKRLLDDLAGESGLRAVVLRGAGDKAFAAGADIKEFPNTRMSAADAAEYNESLAVCLRALTTMPIPVIAAVRGLAVGGGCELATACDVCIATDDARFGIPLGKLGVTTGFTEADTVARLIGPAALKYLLFSGELIGIEEAARW
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MERDFMGLNSKEEAIEAGDSRRTGNHSGVQVQQRSPVQLTIFYKGTVNVYDDMSPEKAQAIMLLAGNGVHVSQPMTTAPSSPVSISPSTGTGSRAAMDATKAMSSLRRVMQSAVPQMRGASLARFLEKRKERVMASAPYNLGKSTLPGSSSRMNKDDKK