lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
GTPase-activating protein (GAP) for rhoa and cdc42.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton.
Sequence:
MATRRAIVPEQQQEPSSPASEISKNKDWQEQSEMVSPTEEEGFCWPGPKSVALRRASEGFGFTLRHFIVYPPESAVHTSVKDEENGNRGVNAGRPRNRLEPMDTIFVKQVKEGGPAHEAGLCTGDRIIKVNGESVIGKTYSQVIALIQNSDSTLELSVMPKDEDILQLAYSQDAYLKGNDSYSGNAQNIPEPPPLCYPRVQPEASVMAQPVEVLPSGTSLATQQSSCPLRTATTQPERSYRVEIQVPPSPTDIVKSNTAVCVCNEAVRTVIVPSEKVVDLSSNRTNRAGPLHRTGLADPSILKRTTSPSSSTPNVPMVPSTRHFDSAGVIGKPPSYGGLAENMFSTRPAAHAEESPSPTNHYASPGSHQHIDWRDYKTYKEYIDNRRMLMYGCRTIQERLDSLRAASQNTTDYNQMLPNRSSGQVRRRSTSHDRVPQSAQMRKRSVSQERLEDPVLMKEWPRSASQDTLTSPAVASRNHRSELWDYLTRKGDFDQFIVETHSNGERNTNYQWSGFTEQDDRRGINERPRQHAFHMSLRSPNFTMAPVPFTSSDNRRGGARVLASAHPLQMVHPDMKTIQPTRNFQNSSRAPHPRPALSDRSGFAISKSNSVKIPTPYAAKPHSPSVRSDDGIVRDQKPVNYLHVGGPQNCQRKTQTESALGFHLDSIKTSMSASSSSPSTSQKVDVKITQSPEANAGDSNAVLSPVDQVVLRERPSPGQQTSPPIRQQSYIFAVNEQEGASDTTCWLPNDARREVHIKRIEQRKASGSNSPGDSLASIPFIDEPTSPSIDHEIGNIPASAVISISAQPLPTITTVPPSPTSPVPLMRRHFSHDHDSIRPIVLEVNSKTERSKSCDEGLDDYKEDGKLCLKQGSSLKGIKARENVQSSEDSESRKDSSSDVFSDSNKEGFLYFRQLTTEKGKRVSGSIRPWKQMYVVLRGSALYLQKDKKEQTGHSSAQSDEEQLIGINGCLIDISYSETKRKNVFRLTTSDREFLFQAEDRDDMLAWIKAIQENGNLNDEQTDQASRVLISKRIKEYNTMMSSSSNKTEPSPKAQRQTLSIRQQFRAGKPDDDISPPKDKGSWRRIMKKPFEKKPTTGGTFGVRLDDCPPAHNNKYVPLIVDVCCKLVEDRGLETTGIYRVPGNNAAISSMQEELNKGNTDIDIQDDKWRDLNVISSLLKSFFRKLPDPLFTNEKYNDFIEANRKEDPVERLKTLKRLILDLPDHHYETLKYLSAHLKTVADSSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQKHDWFFSEESADEPITTVHEESTVESQPVPNIDHLLPNIGRTGLSPGDVSDSATSDSAKSKGSWGSGKDQYSRELLVSSLFAAASRKRKKQKDKPQPSSSEDELDNVFYQKELSQVEFQKPDKQNVDKDMDLKAKANALSLKDADNVKGTNIIKEDKLEKDIMYSEPTSPCPPKLLEPPIANHGLQAPSNDKNIPQINFQMEESMSDSGTMLSTSSQASVQGSKPKVVSPEFKGSDFLTADVSSITSDYSTTSSTIYMTGLDSILISPEVQSVAESKGEEADDERSELVSEGRPMETDSENDFPIFASSLAFDRRHQSKAEEPSRNVQVNSEGSPSCTEGSITPKMDRRRFSSHKLIECDTLSRKKSVQQKTDSDCSAESKTEETLSDAQEAVKKGRSLSIVDPTGNNEPEEPAWRIKITERLKLRLKASADDMFGIGSQKANAAETRKKKNIRRRHTLGGHRDFAEISVLNAWKINEPSSKEAELSAVDRLKPKCPSQDLSISEWLVRERLRTSTSELSTVEPEEKHISETTGQKESASASPPPSSPSQVSTAVLPAGSDSPSHETAPQPDDQMNGDSFQSKNKNNFSPAVDAHPHKLSGTQVVRSRFYQYL
The following text describes a protein:
Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
Sequence:
MADGLGDFEDQPAQQQQEEDPAAAFLAREQDELAGIEDDDVAGSQEETPAAPAQVPSAMDDNLDFLSGGGGDSGSGAADWEGEQQNGDIFGADQGGPQSNGPVPTPAPRREEPEKIRKWREEQKAMLEKKDAEAERLREEWKKEAADELRKWYAQREEQLEKTKASNRVANKELLKQLEDDALATHTRRSRTSAEEAFREEVAESNPGQEWERVARMCDFNPKSSKGSKDTGRMRSILLHLKQEGLQR
The following text describes a protein:
Function:
Involved in glutaminase-dependent acid resistance. Exchanges extracellular glutamate (Glu) for intracellular gamma-aminobutyric acid (GABA) under acidic conditions. The protonation states of substrates are crucial for transport. Selectively transports Glu with no net charge and GABA with a positive charge. Also efficiently transports glutamine and, to a smaller extent, methionine and leucine. When the extracellular pH drops below 2.5, can import L-glutamine and export either glutamate or GABA. The ability to survive the extremely acidic conditions of the stomach is essential for successful colonization of the host by commensal and pathogenic bacteria.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
Contains a unique C-terminal C-plug that plays an important role in substrate transport. The C-plug forms a folded domain and completely blocks the path to the putative substrate-binding site. Under neutral or basic pH, the C-plug probably remains closed and prevents substrate transport. At acidic pH, the C-plug may be displaced, allowing influx of Glu and efflux of GABA.
Sequence:
MATSVQTGKAKQLTLLGFFAITASMVMAVYEYPTFATSGFSLVFFLLLGGILWFIPVGLCAAEMATVDGWEEGGVFAWVSNTLGPRWGFAAISFGYLQIAIGFIPMLYFVLGALSYILKWPALNEDPITKTIAALIILWALALTQFGGTKYTARIAKVGFFAGILLPAFILIALAAIYLHSGAPVAIEMDSKTFFPDFSKVGTLVVFVAFILSYMGVEASATHVNEMSNPGRDYPLAMLLLMVAAICLSSVGGLSIAMVIPGNEINLSAGVMQTFTVLMSHVAPEIEWTVRVISALLLLGVLAEIASWIVGPSRGMYVTAQKNLLPAAFAKMNKNGVPVTLVISQLVITSIALIILTNTGGGNNMSFLIALALTVVIYLCAYFMLFIGYIVLVLKHPDLKRTFNIPGGKGVKLVVAIVGLLTSIMAFIVSFLPPDNIQGDSTDMYVELLVVSFLVVLALPFILYAVHDRKGKANTGVTLEPINSQNAPKGHFFLHPRARSPHYIVMNDKKH
The following text describes a protein:
Function:
May act as an important regulator of the cell cycle that participates in the maintenance of genome integrity.
Subcellular Localization:
Nucleus. Chromosome. Nucleus speckle. Note=Excluded from nucleolus.
Sequence:
MAASRKGKAVKAVKQEDLRRLMQETRRDSGRQKRVESPFARYSGAGQLMCALCDAPVKNALLWQTHVLGKQHKDKLQELKSRTAPAHTPAPAHTPAHTPAAASSSSSTLKRAAEPPPAPGKRAKLQTGAGAGLGLLAGHYDDDDDDEGGAGERKTAPPTDSALPADFFDSGPAPAPPISHSGSVSKAEQQESQEPPENRPESLPEGFFDDPVRDAQVRQVDTPKDQLEREWEEFQKEMRQVNSASDAIVAEDDEEGRLERQMDEIEEQMQCLRRVEELRAKQETARSRRRSQRREEEPMQEEEPLEEEEELMHILTQDWRAKGALA
The following text describes a protein:
Function:
Transcription activator, when associated with BHLH2/EGL3/MYC146, BHLH12/MYC1, or BHLH42/TT8. Involved in the control of flavonoid late metabolism in developing siliques. Plays a key role in determining the tissue-specific activation of leucoanthocyanidin reductase (BANYULS).
Miscellaneous:
MISCELLANEOUS: TT2 activity is tightly linked to the presence of TT8.
Subcellular Localization:
Nucleus.
Sequence:
MGKRATTSVRREELNRGAWTDHEDKILRDYITTHGEGKWSTLPNQAGLKRCGKSCRLRWKNYLRPGIKRGNISSDEEELIIRLHNLLGNRWSLIAGRLPGRTDNEIKNHWNSNLRKRLPKTQTKQPKRIKHSTNNENNVCVIRTKAIRCSKTLLFSDLSLQKKSSTSPLPLKEQEMDQGGSSLMGDLEFDFDRIHSEFHFPDLMDFDGLDCGNVTSLVSSNEILGELVPAQGNLDLNRPFTSCHHRGDDEDWLRDFTC
The following text describes a protein:
Function:
Essential for DNA excision. Site specific recombinase necessary for the excision of the 11 kb nifD element during heterocyst differentiation.
Sequence:
MQNQGQDKYQQAFADLEPLSSTDGSFLGSSLQAQQQREHMRTKVLQDLDKVNLRLKSAKTKVSVRESNGSLQLRATLPIKPGDKDTNGTGRKQYNLSLNIPANLDGLKTAEEEAYELGKLIARKTFEWNDKYLGKEATKKDSQTIGDLLEKFAEEYFKTHKRTTKSEHTFFYYFSRTQRYTNSKDLATAENLINSIEQIDKEWARYNAARAISAFCITFNIEIDLSQYSKMPDRNSRNIPTDAEILSGITKFEDYLVTRGNQVNEDVKDSWQLWRWTYGMLAVFGLRPREIFINPNIDWWLSKENIDLTWKVDKECKTGERQALPLHKEWIDEFDLRNPKYLEMLATAISKKDKTNHAEITALTQRISWWFRKVELDFKPYDLRHAWAIRAHILGIPIKAAADNLGHSMQVHTQTYQRWFSLDMRKLAINQALTKRNEFEVIREENAKLQIENERLRMEIEKLKMEIAYKNS
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
Miscellaneous:
MISCELLANEOUS: Dicyclohexylcarbodiimide (DCDD) binding to the active glutamate residue inhibits ATPase in vitro.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEHVNEILATVGVILQQTQTTQDVNASAKLGAYIGAGVTMIAGSTVGIGQGYIFGKAVEAIARNPEVEKQVFKLIFIGSAVSESTAIYGLLISFILIFVAGA
The following text describes a protein:
Function:
Transcriptional activator, essential for early embryonic development and survival of embryonic stem cells (ESCs). Supports cell growth and survival during early development by transcriptionally activating the expression of the translation initiation factor EIF3B, to sustain global translation. Activates the transcription of FLNC.
Subcellular Localization:
Nucleus.
Sequence:
MEHHGREEMDSKEESPQVWPDSAEQDQNAAQVHFVPEAGTVAQIVYSEEQERPSQQVVYTADGTSYTSVDTSEHTLVYIHPVEATQTLFTDPSQVAYVQQDATTQQVTVLLPAAAQSMNPTNLSVLGSVAESPQQMALEQGQQADRASLPVHNQVLPPMEAVDGSDPLAPLQNQMERMETKEEDDEDEEDDEDGEDTDMDEWDPDPPRPFDPNDLWCEECNNAHPSVCPKHGPLHPIPNRPVLTKARASLPLVLYIDRFLGGVFSKRRIPKRTQFGPVEGPLVRQTELKDCYIHLKVSLDKGDRKERDLQEDLWFELSSEALCNWMMFVRPAQNHLEQNLVAYQYGHHIYYTTIKNVEPKQELKVWYAASYAEFVNQKIHDISEEERKVLREQEKNWPCYECNRRFMSSEQLQQHLNSHDEKLDFFSRARGRGRGRGKRRFGPGRRPGRPPKFMRMEVTIENGEKCEEGTQDLLHFSSKGQFDEARQATLNGLEQQEQTPVPSETQSTLEQQSENHPLQIQPQHDESVVPTQSTMTADDMRRAKRIRNAALQHLFIRKSFRPFKCLQCGKAFREKDKLDQHLRFHGREGNCPLTCDICNKGFINSGSLESHMKFHMDQKTYSCIFCPESFDRLDLLKDHVAIHIIDGYFTCPTCKKRFPDFIQVKKHVRSFHSEKIYQCTECDKAFCRPDKLRLHMLRHSDRKDFLCSTCGKQFKRKDKLREHMQRMHNPEREAKKADRISRSKTFKPRIASTDYESFMFKCRLCMMGFRRRGMLVNHLSKRHPDMKIEEVPELTLPIIKPNRDYFCQYCDKVYKSASKRKAHILKNHPGAELPPSIRKLRPAGPGEPDPMLSTHTQLTGTIATPPVCCPHCSKQYSSKTKMVQHIRKKHPEFAQLPNTIHAPLATAVISSTPAVLTTDSTTGETVVTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSTTGLQQPQHIQLQVVQVAQATSPHQSQHSTVDVGQLHDPQTYTQHAIQVQHIQVTEPSPTAQSSSQVGGQPLSPSSQQSQQELSPSQMQTAASTQSQALQQQQGSSVQHTYLPSTWNSFRSYSSEIQMMTIPQGQYVITETAVGTPVTTVNTGQVKAVTQTHYVISEGQPDLDVKQNSSLSSEVQVGVSQPPTHTDTLESQTSNQQQTTQYIITTTTNGNGGSEVHITKPRTFSAEHE
The following text describes a protein:
Function:
Not known; suppressor of sulfoxide ethionine resistance.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MYSIVKEIIVDPYKRLKWGFIPVKRQVEDLPDDLNSTEIVTISNSIQSHETAENFITTTSEKDQLHFETSSYSEHKDNVNVTRSYEYRDEADRPWWRFFDEQEYRINEKERSHNKWYSWFKQGTSFKEKKLLIKLDVLLAFYSCIAYWVKYLDTVNINNAYVSGMKEDLGFQGNDLVHTQVMYTVGNIIFQLPFLIYLNKLPLNYVLPSLDLCWSLLTVGAAYVNSVPHLKAIRFFIGAFEAPSYLAYQYLFGSFYKHDEMVRRSAFYYLGQYIGILSAGGIQSAVYSSLNGVNGLEGWRWNFIIDAIVSVVVGLIGFYSLPGDPYNCYSIFLTDDEIRLARKRLKENQTGKSDFETKVFDIKLWKTIFSDWKIYILTLWNIFCWNDSNVSSGAYLLWLKSLKRYSIPKLNQLSMITPGLGMVYLMLTGIIADKLHSRWFAIIFTQVFNIIGNSILAAWDVAEGAKWFAFMLQCFGWAMAPVLYSWQNDICRRDAQTRAITLVTMNIMAQSSTAWISVLVWKTEEAPRYLKGFTFTACSAFCLSIWTFVVLYFYKRDERNNAKKNGIVLYNSKHGVEKPTSKDVETLSVSDEK
The following text describes a protein:
Function:
Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids. Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting.
Subcellular Localization:
Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Mitochondrion membrane; Single-pass type II membrane protein.
Sequence:
MRNQSKRQPSSRAFGSMNFRNRAISPGPHNVNILELRPGRWLRIQHILGKHQQGDDGDYSQGGSSSGQPNGSGPAQRHVSEGSTTMETKDLKQASNTTSNSRLRNHLPSGNNENMHNQSNSNTTAKKENHQPPSGKADAGSSSSSHSKVATKQRQSVQSKTSVNSEHVRRNRHTSKWSSQVSLISLMDEPGTVLFFLHGVGGCAEVWYHQLQYFQEAGFEIVVPDMLGHGFSRAPKQTAAYKFEELAEDVLAIFDRYAKKRNVLIGHSYGGSFCTLVAKERSRKVTKVVLISNGGPIPLSPEPCHLFCLPSCCLACIKPIINRTFARQAFHTKAERSAVDLRNAFDIPAYVLRATMQGQYWQEGGSDYHSSLSVGVLIIHGCEDELVPQKESETMQETIYASQLELVESAGHMVMVEQPQKVNKLLHAFILKDMTISLAMQRGHVTNHLTNPPDAAAFLPSPLQRHKTVPNFSIT
The following text describes a protein:
Function:
May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.
Subcellular Localization:
Cytoplasm, perinuclear region.
Sequence:
MEFHVQYPQLSSCHTRTQTVSQIDMENQQHYEGCSAGCSLQSSQSLEDPVCMDPTCRAPSRVDSCPDMDTRPPLTPELNIMDLDGDVPGEGFHMQELLSELATLEEPLELRPSLDCLNETSNNPLEEQQEGQAECEPCPLHIAMGKGLTQKLRRVSESEILLSNSRGLFLTDAGSEELLHLFQHEEGVLADVGSAVPLARLEELPKNKSSVSCSLQEAGAGSFEEVKQKSSSYTSNLCREDSFSSLEEVPDVESLDTPSATSSIAKVPGPCDPEDLQDGVIFGAQYLGSTQLPGEKHPVASTRMRQAQEAVERIKAPDGESQPMTEVDIMVSTRRVKVLSADTQESLMDYHLHTISYTADIGRTVVLMARRKIPHTQDHSPTQRKPNKILCHVFQSDDAQLIAQAIGQAFGLAYQKFLRSEKAGPLTSGTGQREEQLYNADLPHFSKSDNCREVYIQKQRGEMLGIAVVESGWGSLLPTVVIANLMHGGPAERSGDQSIGDHVTSVNGTSLVGLPFSTCQSLIQDVKGQSEVILSIVRCPPVITAIIQRPSVSHQLGFCIEDGVICSLVRGGIAERGGIRVGHRIIEINGQSVVATAHEKIIQTLMDATGEVHIKTMPASTYRLLTGQEIPVYL
The following text describes a protein:
Function:
May be involved in vacuolar sorting and osmoregulation.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
Sequence:
MAATSRLKGPTEASWIATLLLLAALAWSAYNFSSRTPSPLPFDAPLNSFSEGRARRHLDHIASVGPHPVGSPALDSVHNYLLQELEWIEEHASGKVVVEVDVQEGENGVSQLSVGPFSGKSLAYQGLRNVVVRVRGAQWGVKDETSESWHAVLLSVHTDSVYPSPGASDDAASVAILLELIRTFSLSFPASVGANALLFLFNEGEEEGLDGAHAFITKHRWSDNVRVAIDLEAMGSGGPHTLFQAGPSNWLLNHYVESAPHPAGNIVAQDIFLNNLINSATDFQVYRDVGGLSGLDFAYIKRGHVYHTKNDRPEYVQPGALQHSGDNLEALLRRVVVSTELAEQERVFPPEGSSKPVPYENVFFDFLGLKLISYPFAQAASSYLTLSAILPVLVLLPTIFPSQKGPAYARVTIPRAHFFLVPLTAFLTQALTLVGGLVMAGSRAYLLAVSKPWPNPAYARPWLVVPLYGGAALAGAIGVQGLGAAALRKVLAKTPSISVESVLFRASLLQWFALLVVMTRAGVGSAYIPLLWALAGTLACTVRPKVRMEASLLSTPGFAATALAASLTATAAIGLTDVMNSSAGRFDKSPGASPVYLLEVVISILVAVFALLATSYFLPYAHSKGLKSSFTIAAFFLAVSSIAAGLVTWDVFPPFTAEAALPINLVHVYDTSAQQSYISLSSLAPGRSVEGLVAGLGARFNVSRGSGPDFVTYEVGYGARTVDAVPPPPGVKTEAPSFALLFDHHVAHELETGVKEIDVGMHAGGSRRWALGIDVRRVQGFSISSVTGDGRLDRSSAKVLVPMTVDPVASDSKAGWHIVQFAAGSGPADDFVMKLRIHPDAHVERLNSDAGGAYHTEGRPLLKLRTDFDVTTPHLQAVLDELPVWTTEFGKSTSPYRLAYLASFDFE
The following text describes a protein:
Function:
Catalyzes the interconversion of L-alanine and D-alanine. Provides the D-alanine required for cell wall biosynthesis.
Sequence:
MQAATVVINRRALRHNLQRLRELAPASKMVAVVKANAYGHGLLETARTLPDADAFGVARLEEALRLRAGGITKPVLLLEGFFDARDLPTISAQHFHTAVHNEEQLAALEEASLDEPVTVWMKLDTGMHRLGVRPEQAEAFYHRLTQCKNVRQPVNIVSHFARADEPKCGATEKQLAIFNTFCEGKPGQRSIAASGGILLWPQSHFDWVRPGIILYGVSPLEDRSTGADFGCQPVMSLTSSLIAVREHKAGEPVGYGGTWVSERDTRLGVVAMGYGDGYPRAAPSGTPVLVNGREVPIVGRVAMDMICVDLGPQAQDKAGDPVILWGEGLPVERIAEMTKVSAYELITRLTSRVAMKYVD
The following text describes a protein:
Function:
Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
VRNEECALSHSSLCIIARAVRGTPSLMINVILHSIVNQDADGGRRFDEYVHTDEFPNPLETAARLRREKRERHKKMCNIWVWAEIFFFVFILGLLGLVVSYHQKLHAKNECGMTYIYRPMIFNPIPVQGNNVDKYTLLRYHEGYRDESVLDVDIPVLFVPGSSGSGKQVRSLATTIINSTAELGDKFKYRFVFYACDFDEEFSFLSGATLIRQREFVVKSIETILNTYSPTGVKKLLLMGHSFGGTILHSLPAHPRADPKWMDLVITLGAPINAPPFKSDFYMEAFYENTMKAWNNRKDELSHITLISYSGGIKDFMVPDHLARNPFKYTKEMGVIAGTRDSRVLYRPSWSLRDVATDVDHNCLAWCNQLIKHISGLSIRYGMEWKMPKGGVMKASRQVVKEFYVQKIGAENKVESRKDPQPLFNNSIYIQEEKRKVKFTEEYPYVKIDLDLRQYDMIAYIRARALTCSQGITARHADLTFRSSENFTTYSIQEGEWMYMRIFPVFPETERLKGILRIGGTPDCEYEIESHYEVIGTMYRRLMDSTSLPFFVFYVLFIFAMIPVISLNRVPPPFDYIYGDLPDYFYTGLFLTGAIGSALLTVTLRYEVERNFLTYWVWVGGTRLISVLICLPAQPVIRLISRRITRCGLQMRAVGRVVLTVISLSIASHNINLGYASFLFINLFKVGTHSKNGIAFIIFSISILMSIGLAGNVRDGPSGVFQRSISEGTANSYVQGVLNVFYEHPHPLLFSFVTLSFCSLLNFSHMLRAVDDSAKEKITGVFYCMLSVSVFRVTNLEAMAVVTTYYILLFESMKDYKGLKAGDGKNVD
The following text describes a protein:
Function:
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Subcellular Localization:
Cell membrane, sarcolemma; Single-pass membrane protein. Cytoplasm, cytoskeleton.
Sequence:
MVGNGEEVAEPGIHLTAGLLGGLPEARGQQILNLLVGRLFVHSLEPAAFLGVEDHAGPVPHEPMTFHPHLLDHPDLPQWLRYTQRTPHQSGFLYGSPTQTDRGRLVIEVTAYNRRSFETARQRLVLDIGDPTGPRLPLEAEFLLCSHDVEEALAPPTTRRFLEALQGLWAPGDLQLLNVTSALDRGGRVPLPIEGRKEGVYIKVGSASPFSDCLKEARTPSNLQRCQQGQQPVLSCYDSFGPQFRIDWCNISLVDKSVLPPPTAGPTWGDGILEQDPHFNPPTEAPSRSFLAEALLTLLLPLLLALLLTLLLAYIMCCRREGVIKRDLATSDIQMVHHSSILGNTEELRQMAASRVVPRPLSTLPMFNVRTGERMPPMYDGARVPLIQAQH
The following text describes a protein:
Function:
Binds specifically to the 3'-terminal U-tract of U6 snRNA.
Subcellular Localization:
Nucleus.
Sequence:
MINIFPLSLLLTAKGSDVVIEVKAGDTYDGKLELLDKFMNAKLTNVKHTSKDGNSFHGIKELLIKGNSIKYFRLNPDAEKKAQEEAEIYEQQQQQKQQKQNEQKQQRKAQNQKSRGKSYPQKQPQQRR
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular Localization:
Cytoplasm.
Sequence:
MPASFKRYVEVGRVVLVEEGPSAGELAVIVEVIDQNRAIIDSPSTGVTRQAFAFKHLTLTKLTVPGLPRGAGSTAVKKFFDKAGVAEKWAQSGWAKKRAAIKVRRSLSDFDRFNVMLLKKQRRSVVSPATKKASA
The following text describes a protein:
Function:
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MAEFANASHEVINVTLGTTLAATTKLVMPTPAKPILPVQTGVQAQQEEQSSGMTIFFSLLVLAICIILVHLLIKYRLHFLPESVAVVSLGIIMGAFIKIIEAQKLANWKEEEMFRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFSVFGTAISAFIVGGGIYFLGQADVIYKLNMTDSFAFGSLISAVDPVATIAIFNALNVDPVLNMLVFGESILNDAVSIVLTNTAEGLTRENMSDVSGWQTFLQALGYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFGMMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFMCETCVFAFLGLSIFSFPHKFEMSFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYALSLHLGLEPIEKRQLIGTTTIIIVLFTVLLLGGGTMPLIRLIGIEDSKARKRNKKDVNLSKTEKMGNTIESEHLSELTEGEYEAQYIKRQDLKGFMWLDAKYLNPFFTRRLTQEDLHHGRIQMKTLTNKWYEEVRQGPSGSEDDEQELL
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MQESLFPGRKGRAEWRNGDIVIPGGGGPVISSPLDQFFIDPLFGLDMGNFYLSFTNESLSMAVTVVLVPSLFGVVTKKGGGKSVPNAWQSLVELIYDFVLNLVNEQIGGNVKQKFFPRISVTFTFSLFCNPQGMIPFSFTVTSHFLITLALAGVRIFLMRIIQA
The following text describes a protein:
Function:
Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. May be involved in lateral roots and nodules formation.
Subcellular Localization:
Cell membrane. Endomembrane system; Multi-pass membrane protein.
Sequence:
MSEELSCKSSLDVPLLPQWNHLDEKANIASHHSTKNTIVSLFAPALMDSMQYQHVDERCMDKNSNIKTYPNIGELAFGKTGRLIISVSMYMELYLVSTGFLILEGDNLSNLFPIGEIQIAGLAIGGKQLFVILVTLIILPTVWWDNLSLLSYVSTSGVFASAFIILSISWTATFDGVGFHQKGTLVNWNGIPTAVSLYAFCYRAHPVFPTLYNPMKNKHQFSYVLFACFLLTTVGYASMAIICYLISKLAIYTTLVNPISKFALMVTPITDALKELLPSTYRNKVTSILGSTVLVMSTAIVALIVPFFGDLMSLVGAFLSIMASILLPCLCYLEISGTYKKFGYEVVAIVAIIIIGIVMGISGTTTTK
The following text describes a protein:
Function:
May be involved in collagen fiber assembly.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MWPLWLLASLLALSQALPFEQKAFWDFTLDDGLPMLNDEEASGADSTSGIPDLDALPPTFSAMCPFGCHCHLRVVQCSDLGLKAVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKISRSTRRPSAPDGLKLNYLRISEAKLTGIPKDLPETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLSRVPAGLPDLKLLQVVYLHTNNITKVGVNDFCPVGFGVKRAYYNGISLFNN
The following text describes a protein:
Function:
May play important roles in cardiac development and/or cardiac function.
Subcellular Localization:
Nucleus.
Sequence:
MGNTIRALVAFIPADRCQNYVVRDLHEMPLDKMVDLSGSQLRRFPLHVCSFKELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPEVVCELSLLKTLHAGSNALRLLPGQLRHLQELRTIWLSGNRLTDFPAVLLHMPFLEVIDVDQNSIRYFPSLAHLSSLKLVIYDHNPCRNAPKVAKGVRRVGRWAEETPEPDPRKARRYALVREESQELQAPVPPPPLPPTNS
The following text describes a protein:
Function:
Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
Subcellular Localization:
Nucleus.
Sequence:
MATFEPGAVLKEFQDNNFKLEDAAVGDACANMAQSFGLTPEELVESWEVFYLNMKVKTNNTVTKGALENFRKHLERDRVEAFKKKQPAVHFYTKDDLEDVDMDQPSTPWKSGVKPTTGLSPQPTGRSSGIPTTQKPIAADPGSPVTPLFPAPATPSKTLFQATPASAFKQRTNSGAVQLIFDQPLEGESASGMEVDGEASEQPCQIEAARNWASESYRYMYDRVEDKANALEKRLLAFGAALARAEDCSTSHQVYAASQDTVTVVGRICCDTEGGRINEHSVLLEGSQEHSNGERVKLDLRNVPHFSIFPGQTVGVEGQNPSGHCLVASRLFDALPPPPASATADTGVNGNTSARLPSMMVAAGPFTAADNLAYEPLEELLSVAKARRPDVLLLLGPFVDREHPHVRQGTVDAHLEDVYAEQVQKKVEAFCEEVGSGVKVVVVPSVRDSHHDAIFPQPPFSLDWKDPGKEITFLSNPGVFTANGVRVAVTTMDVLKHLSSEEAARVAPGAASDRMARLAGHILGQRSFYPLFPPALGTPLDLSLAPNALELTSLPDVLVLPSDLAPFVKVLSAESKEGGQSSQPAQVLCVNPGRLSKGTSGGTFSYIQSKASRGVAGKANPAKVEIIRI
The following text describes a protein:
Function:
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
Subcellular Localization:
Nucleus.
Sequence:
MGLEEELLKIGRRLERRFSEGNTDRILELLKELQAIEVNVTLLRSTRVGVTVNKIKKKSDERKVIELATAIIKDWKKIFESSYKDKGTKATSDVVKPTQSGPARISSPTSKNLHVERPSQCPASYKPSHTQQDIPKEPKLKRSYSEDVQPSIQTEKKKERSHSPTIQPSLQVVKKPERRHSTNDKSFLHATKKPERVHSTDVQSSDHTTKKPERSHSTDVQSSLHTAKKTERGHSTDVQSSLHTAKKPERSHSTDVQSSLLTAKKPERSHSTDGQSTLHTAKKPERNHPTNAQTTVEIPKKPERRHSLSSPLQSSASCKSPTNTKEERKFSAGSPVQPTRNGSTKLFSDAEKQGQTAKVSTQYQHIEFSLCPRRHSLSSPLQSSASCKSPTNTKEERKFSVGSPVQPTRNGSTKPFSDAEKQRRHSLSSPLQSSASCKSPTNTKEERKFSAGSPLQPTRNGSTKPFSDAEKQGASGGQMGSPVDIHSPSSCLLGPCYLTGDSVRDKCVEMVASALKTDDDYKQFGTNCERLAWEIEECIYSEVKVTDMKYRNRIRSRISNLKDPKNPNLRKNVLCGVVTPQSIATMTAEEMASDELRELRNTMTQEAIREHQMAKTGGTQTDLLQCEKCKKKNCSYNQVQTRSADEPMTTFVLCNECGNRWKFC
The following text describes a protein:
Function:
May modulate the function of nicotinic acetylcholine receptors. May enhance sperm motility.
Subcellular Localization:
Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome.
Sequence:
MRKMNTLLLVSLSFLYLKEVMGLKCNTCIYTEGWKCMAGRGTCIAKENELCSTTAYFRGDKHMYSTHMCKYKCREEESSKRGLLRVTLCCDRNFCNVF
The following text describes a protein:
Function:
Acts as a positive regulator of the mitotic cell cycle and as a negative regulator of sexual differentiation. May be involved in the transcriptional regulation of the cdc22 and cdt1 genes. Is an integral component of the DSC1-like complex.
Sequence:
MYNDQIHKITYSGVEVFEYTINGFPLMKRCHDNWLNATQILKIAELDKPRRTRILEKFAQKGLHEKIQGGCGKYQGTWVPSERAVELAHEYNVFDLIQPLIEYSGSAFMPMSTFTPQSNRKPTEAYRRNSPVKKSFSRPSHSLLYPYTSSNNMTSTSRMSGIHDALSLQSDFTRSPDMPSDSFTGSLHDIKASPFSSNNYAQSLLDYFLLPNTTQPPDFVYDRPSDWDVNAGIDEDGHTALHWAAAMGNLEMMHALLQAGANVVAVNYLQQTSLMRCVMFTMNYDLQTFEVVSELLQSAICMNDSFGQTVFHHIALLASSKSKMEAARYYMDILLQNLTATQSVDVAAQIINLQDDHGDTALLICARNGAKKCARLLLSFYASSSIPNNQGQYPTDFLSSKDMSFPENDDSPLNSKIEDNLIDNLKYPQSLDDHLSSKKPISYFSNKLTHQTLPNVFTQLSELSKCHEASLAEKQLTYNLAMEALEQTVRETETCQRLWNERTNNDENYLVNQREDLIHQCKKFLHTLKTARYYLETVQLHQLKKYVTYFSQIWSTDELADISETKNLVGHDTKTNRSSLSSKHEVDLFTAENEAAREKLVEQLCSLQAQRKQKINEILNLLSMGMYNTINTDQSGS