lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.
Subcellular Localization:
Secreted.
Sequence:
MVHVMGDAGCWLLLGLTLLPIAVLGSQDDGKVIHISRVQHQAVRVGLGEPVALPCLFLLHPSASLGPNEPPDPPRVKWSKVRSASGQREDVPILVAKDNVVKVVKAYEGRVSLPGYARDRYNGTLLLRAARASDAGLYRCEVVAGIDDEQDLLPLEVMGVVFHYRPAGARYALTFAAARRACMDNSAVIASPQHLQAAFEDGYDNCDAGWLADQSVRYPITLSRPGCYGDRNSLPGVRSYGQREPGELYDVYCYARELQGKVFYATAPGRFTLSGARRHCRGRGAALATTGQLYLAWREGLDQCDPGWLADGSVRYPILAPRRKCGGEAPGVRTLYRFPNRTGFPLPASKFDAYCYKGDAAGAPDSSAEQRELEPLGSDNVLVEHEDMATSGDSPRAGVLPQLGAAGPGGAEDEQLRLASSVTAAWRGDIPGGSSMASASSPSSSVRPLEDEALNAVDPALRGSPRELFGTSPAPALREFPDPTEPLFTLHPQTQSPAQEVTSLPPAAPALGTVPIVAAETPGTPKQSSYAGLNGRYFQLQQQSRDPSVVQDPTVAGDHTVAEDPVGTVTQAPILALEVKGAAANAVETWSITRPSAESPHRGGPYPLSNEVEEEVGHKLLAPSTIPVPPSRRDLPQWSPPTSPHGPGGPTRTSLPSSPPTLMAPGDTSHHQDISTGEAQPRGDSPQPPADVIEDFSGDVAPKEDDSPIPPWPPLPPAPLVAEGPGTAAQPSSDSSGALGDGSLERQRKAVTFVLPPVGLPGSPSPTALSSPHPQSRLSPTVPQGALKMGAEPTHEHLDVGTGPWDEAAITSVAPDVPSAPPTDSEVTPGLGSEWPSEGSGRVGDGPTAAPQHPNPSVPGLEGEEYPPHPLDPQQPPSPGEEDTSGEAKSDPPPSTATHSPAPPDTHWPSPTAPHPWVPEGPEAPSAGPLFEPTTPGEAGGALLLDADSGSGEEPVLEERELLVWADTSNSSQHAPADPCQTNPCLHGGTCHANGSICGCSCAPGFTGENCEIDIDDCLSSPCQNGGTCIDEVNAFVCLCLPSYGGSRCEKDTEGCDHNWHKFQGHCYRYFSRRRSWEDAERDCRRRAGHLTSIHSQEEHGFINSFGHENTWIGLNDRIVEQDFQWTDNTGLQYENWRENQPDNFFAGGEDCVVLVSHEIGKWNDVPCNYNLPYICKKGTVLCGPPPEVENAFLVGKKKERYSIHSSVRYQCEEGFTQRHIPTIRCHSNGKWDRPKLLCTKPRRSHRARRHHRHRHSHPHHQHHHHKPRKERRKHRKHLRLDWMEEGHYF
The following text describes a protein:
Function:
Required for septate junction assembly, possibly by organizing the preassembly and transport of septate junction proteins such as dlg1/disks large 1 and Nrx-IV/Neurexin-IV. Involved in paracellular barrier functions of trachea, hindgut and salivary gland mediated by epithelial cell septate junctions. Involved in paracellular barrier functions of the hemolymph-brain barrier (insect blood-brain barrier) mediated by glial cell septate junctions. Required for maintenance of septate junctions in imaginal disk epithelial cells. Involved in the epithelial cell wound-healing response. Directly or indirectly mediates cell-cell adhesion during septate junction formation.
Miscellaneous:
MISCELLANEOUS: The name coiled reflects the excessively long and convoluted tracheal dorsal trunk phenotype of mutant larvae.
Subcellular Localization:
Endosome membrane; Lipid-anchor, GPI-anchor; Lumenal side. Endoplasmic reticulum membrane; Lipid-anchor, GPI-anchor; Lumenal side. Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Cell junction, septate junction.
Sequence:
MKSWEIAVVLVAAVYLCSQVNFVAGLECYVCSNQTGNTEKCLNTIKTCEPFENVCGTEIRWGSQPYFSEGALKQYYVSKRCMTKEQCQSKRKRYMQLYCTHIWYEDWACNECCKGDRCNYFVISGAPSRQGYGVCLTLLTALLGLGSWLIPRS
The following text describes a protein:
Function:
Mitochondrial protein that contributes to the enhanced virulence of C.glabrata strains that acquired azole resistance.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MSDSREIKKPWWFKKAKEWADEFYTRDQKLEDSDRRDLSKKYATISKASVVGAATGLSAGLGGPYAYRYYTTGALKGVKLPRTILLGVVSMVIMRNVAAKIAWDKELKKLDPSGELKQNYKSAHKTVDDVSLSDNSTSVQKKYGMMKFLKYRTAPRWAMYFEGTYQHPDRKFPNPDQMVQDLKGSRRAFPPFFSKADKFWHQIDRKDNDHT
The following text describes a protein:
Function:
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
Subcellular Localization:
Nucleus.
Sequence:
MAGTFGCGFIIINLKMESESHEITSTSDKTTSQEVNNVVQSWIIDYYFATLCRLFRERSSVEFRKELKLFEGLVDELESHSSQRTVCCFLARVMDGENLDVRYDHVARITPLMSAVPVWESLKDFSDPTLHGKIQTLLMVQKGYDKLAKETLQWLEEQTDVPEKLQRKLATIVNKKDAYDQILMNFSFDKLMETIDTFLEAFNQQYASVFLLEAASKVVQARHERSELEETEETPPSLQSDKSESENEEHEDPLVVNIRPKRRLLPKQNDPWKPETAKKAHATLKRTSICKVSRRSNTPSELHSNITVSRHSRKKWTDVEDKKLKAGVKKHGVGKWSKILNDFDFDNRTTVNLKDRWRVLKKQNLVS
The following text describes a protein:
Function:
Binds to intron-containing transcripts and is involved in quality control for the export of spliced mRNAs from the nucleus. Binds to pre-mRNAs until splicing is completed or until faulty mRNAs are degraded. On correctly spliced mRNAs, GBP2 and HRB1 recruit MEX67 to allow nuclear export. On faulty mRNAs, GBP2 and HRB1 associate with the TRAMP complex that guides those pre-mRNAs to the exosome for degradation. Binds single-stranded telomeric sequences of the type (TG[1-3])n in vitro. Influences the localization of RAP1 in the nuclei. Involved in modulating telomere length.
Miscellaneous:
MISCELLANEOUS: Present with 2540 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Chromosome, telomere. Cytoplasm, P-body. Cytoplasm, Stress granule. Note=Nuclear at steady state. Export is dependent on active transcription and the export of mRNAs in general. Depends on MFT1 and HPR1 for nuclear export. Becomes predominantly cytosolic after exposure to hypoxia.
Domain:
RRM 1 and RRM 2 recognize preferentially RNAs containing the core motif GGUG. The atypical C-terminal RRM domain (RRM 3) does not interact with RNA/DNA, but is crucial for interaction with the THO/TREX complex.
Sequence:
MERELGMYGNDRSRSRSPVRRRLSDDRDRYDDYNDSSSNNGNGSRRQRRDRGSRFNDRYDQSYGGSRYHDDRNWPPRRGGRGRGGSRSFRGGRGGGRGRTLGPIVERDLERQFDATKRNFENSIFVRNLTFDCTPEDLKELFGTVGEVVEADIITSKGHHRGMGTVEFTKNESVQDAISKFDGALFMDRKLMVRQDNPPPEAAKEFSKKATREEIDNGFEVFIINLPYSMNWQSLKDMFKECGHVLRADVELDFNGFSRGFGSVIYPTEDEMIRAIDTFNGMEVEGRVLEVREGRFNKRKNNDRYNQRREDLEDTRGTEPGLAQDAAVHIDETAAKFTEGVNPGGDRNCFIYCSNLPFSTARSDLFDLFGPIGKINNAELKPQENGQPTGVAVVEYENLVDADFCIQKLNNYNYGGCSLQISYARRD
The following text describes a protein:
Function:
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. Involved in post-translational modification of various type-I polyketide synthases required for the formation of both mycolic acids and lipid virulence factors. Acts on Pks13, Mas, PpsA, PpsB, PpsC and PpsD. Also acts on AcpM, the meromycolate extension acyl carrier protein. In addition, is involved in the activation of the acyl carrier protein MbtL and the nonribosomal peptides synthases MbtB and MbtE, which are involved in the biosynthesis of the siderophore mycobactin; Required for the replication and survival of Mycobacterium during the acute and chronic phases of infection in mice.
Miscellaneous:
MISCELLANEOUS: Identified as a drug target.
Sequence:
MTVGTLVASVLPATVFEDLAYAELYSDPPGLTPLPEEAPLIARSVAKRRNEFITVRHCARIALDQLGVPPAPILKGDKGEPCWPDGMVGSLTHCAGYRGAVVGRRDAVRSVGIDAEPHDVLPNGVLDAISLPAERADMPRTMPAALHWDRILFCAKEATYKAWFPLTKRWLGFEDAHITFETDSTGWTGRFVSRILIDGSTLSGPPLTTLRGRWSVERGLVLTAIVL
The following text describes a protein:
Function:
Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism.
Subcellular Localization:
Secreted.
Sequence:
MPMAPRVLLLCLLGLAVTEGHSPETAIPGCHLHPFNVTVRSDRLGTCQGSHVAQACVGHCESSAFPSRYSVLVASGYRHNITSSSQCCTISSLRKVRVWLQCVGNQRGELEIFTARACQCDMCRFSRY
The following text describes a protein:
Function:
Has antibacterial activity.
Subcellular Localization:
Secreted.
Sequence:
GLMSVLKKAGKHVAKNVAVSLMDSLKCKISGGC
The following text describes a protein:
Function:
Part of a complex that plays a role in tracheal liquid clearance. In both larvae and adults, contributes to the behavioral response to salt. Probable role in sodium transport.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSDVPGEDSPTHFYPVNFENYLRPKQSIKCQPLQRFKKPNERATNLYRNLKRLKILRWYNRVSKRFEEFPLPKFLGFLQARNDDGLCKRKTGFEIYCEMASIHGFHIFVGAKTWQRILWWLLICNAVLLSFTLVIMSLSMSKETPTIRFIDTMMKPTAEVPFPAVTICGFNTKEWMNSSQIVNQRNASWLELLEDLALPICPQIKICQWDNRMVNCLDQLQPIWTLDQRLCCSFNYNKQLFSSYLGVSFVLRSNDEILQSSKSAGFEVLIHESHEIPNGATPRVFVPGESDAHIMLRPYINRFTKNLKGLSLQKRGCYFSTERRLILSDVYNQINCLAECRTESILKSCGCIPPKSPIEKSWLICDLKQMQCVIDFDHDEIISGEQKNCDCLPPCEFNRYEFQSDIRFIKGMINNSIVNTSNQETTNEVRVRVYYDSAIAEELLLDVYENWLTFIGTFGGITGLFMGCSFVSVFELIFFSCVRPTCNWLTRQQILWRRRRNQRVGITESRSLGPAN
The following text describes a protein:
Function:
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR. Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation. In the WMM complex, anchors component of the MACOM subcomplex in the nucleus. Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B).
Subcellular Localization:
Nucleus speckle. Nucleus, nucleoplasm.
Sequence:
MSKIRRKVTVENTKTISESTSRRPSVFERLGPSTGSTTETQCRNWLKTGSCLYGNTCRFIHGPSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDSESQKRNTEEPSSPVRKESSRGRHRDKEDIKIVKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMDKREEIIIQKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKASSAGKKERKAAVVASPLLDQQRNSKGNQSKKKGPRTPSPPPPILEDIILGKKYKEKYKVKDRIEEKPRDGKDRGRDFEKQREKRDKPRSSSPGQHHSPLSSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPSLRRSASPYPTHCLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREETRGKRDREKDTREERESEHDHRDDREPRDSRDRRDTRDRRELRDSRDMRDSREMRDYSRDAKESRDPRDSRSARDVHDYRDREARDAHARDVRDARDARDARDARDIRDVRDVRDVRDVRDVRDVRDVRDVRDVRDARDVRDVRDARDVRDVRDVRDGHRKEDVYQEEARSYGRNHLREESSRVELRNDSRNESRSEIRNDRMGRSRGRGPELPEKGSRGTRGSQMDSHSSGSNYHDSWETRSSYPERDRYPERDTRDPARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRSEELERDERREERRIDRVDERRDDRVRDRDRDREREREREREREREREKERERELERERAREREREREKERERERERERDQRDRDHDREREREREREREKEREREREERERERERERERERERERERERERERERERERAREREKERERQREWEDKDKGRDDRREKREDIHVREDRIPRDSHEERKSKKRYRNEGSPSPRQSPKRRREHSPDSDTYHSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKSERKESSRRYEEQELKEKLSCGDRQREQAESVDSSRVRAQDLLSHRQAEDRDRDGSDRAHDEKKKAKAPKKPVKKKKEEDVGVERGNLETHEDSQVFSPKKGQKKKNIEKKRKRSKGDSDVSDEEAAPQNKKKRGPRTPPLAIKEELADISTDKDGVLEDPLKKENTAFSDWSDEDVPDRTEGLEAEHTAATATPGSTPSPLSSLLPPPPPVAAASTAATALASSAVSATTSATSSSSAATSNTNGSEDSHRKCHRARGEKVEVSHVTLEDTPHRKLVDQKRSSSLGSNRSHRSHTSGRLRSPSNDSAHRSGDDQGSRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERDRRDPRQREWDREAEKEWPRTRDRDRLRERDRDRDRRRDLDRERERLISDPMERDRERERTFETSQLESGKRSEVKLESEHERDLEGSSRDSVALDKERMDRDLGSVQGFEDVSKAERTESLEGDDESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQEEEKMPDPLDVIDVDWSGLMPKHPKEPREPGAALLKFTPGAVLLRVGISKKLAGSELFTKVKETCQQLVEKPKDADSLFEHELGALNMAALLRKEERASLLSDLGPCCKALCFRRDSAIRKQLVKNEKGTVKQAYTNTPMVDNELLRLSLRLFKKKATCHAPGQEKTEDGKLGPCSIQQELCVS
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MILRLLLCFLLPVSLYAARDTGYYSAIVRVERLLLAERKMVGKIKHYISQGGEVTGDLRSFVDSYEDSWLHPTRDDPLHFAHHPVGAYLLIKRLSQNHMEDIFQQAQDLIEKPSILVDLPDKDDLEMSAFALVRLQVVYSLDISSLVFGQVVMTVTSPHKGPQWIAITDVEPTLTLDLTDTMFIGDVAVKQNHFEDAISWYNFNLISANGPAEKAKVLSRIAIAHSKLKQHERALAIYEEALQLDPDNQILYADYDDAKLLAANDDTPTEEIPAEWIAQRDKSQHLCRLDVLQMQAPPRRGLKCRYIRDSPHLYLSPAKMEVLHRKNPRLVMYHDVISQNEARTLRSTAFPKFSRALSMDDEGRIFIDKYAISESGTILDTEDAFIEKMSKRVGHVTGLDTELPYAEPLMVVNYGLGGALQHHLDYMAEAYRHITDVVGNRMMTFLIYLNEVEAGGAVVFPEIDLITPAVQNAALMIQNLKKSGDFVPLTLHAACPVLIGSKWTAVKFIREFGNEFKWPCGLTPAE
The following text describes a protein:
Function:
Involved in protein precursor import into chloroplasts. Part of the motor complex consisting of a co-chaperone (TIC40) and a chaperone (HSP93) associated with the import channel (TIC110). Causes the release of bound transit peptides from TIC110 and stimulates ATP hydrolysis by HSP93. Involved in reinsertion of proteins from the chloroplast stroma into the inner membrane.
Subcellular Localization:
Plastid, chloroplast inner membrane; Single-pass membrane protein.
Sequence:
MASSSLLRQRLLCGGSLGLHLARSKERLCSATGAQWFHSQCYRSTGLPFLLGRQPRRHRAGVISMDGGASKAKRQSTAATAGGEAEPDHSLRSSIASRAGEAPAEEALEEQETEGIAEEEDYEEEVVIVQRPVRQRNGASYQASVRQEAVPSPPSSSYPGSPLFWVGVGVALAVAGSWIGGKVKEQAVNAAWKAMTSGAGNGGQPGFNPMGGPGSNPFGMPGGAGPNPFNFPGMPPMPPPPSGPQPPKATVTDTTATPVQPAPKAKQPATQAAQPAAAAKAEESTVKPKRASFRDVNQEELKIEEQKIKEEPTRANFQEAEVINEGTSTSGGAAFGSGASGSNMTVDMLEKMMDDPMVQQMVYPHLPEEMRNPETFKWMMQHPMYRQQMEEMLSNIGGNEQLMKGLDINSPEVKEQFDKIGMTPEEVVGKILSTPDVAQAFQNPRVQAAIMDVTANPMNIIKYQNDKEVMNVFDKISTLFPGMP
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MLNKCRVCLGFSENMKHVTHGDPLATMYTSLTKFEWIRDENIASSLCPECETTLEKCHTFLEKCKKSHAILLKEIEEKSEIKEEENDFDDESESEGKNKSHLEQISVEEVEKAIFEYQERQKGGTYTCIVCNYVLISLRALSGHMSMKHKDVRANWCHICNQTFDNLAEHNHRLLESCPFCEKTIAKKYFVEHLKAHAGIRTIQCCFCTNKFATYSALQWHYSTKHSDEMKNDIATTKRKFCQICNKRVRSLPRHNSQLHEKTSAPKTHICHFCTKELKTESGLKTHLKLHKSDGRHTCSYCGKPHRDRATMIQHERTHTGEKPFICSVCGKGFAQSSGLNTHMKLHTGRPEACHICEKRFCRPSELKLHLRKHAGEKPFLCTECGKAFKQKSHLTEHMNAAHSDVRPFECHYCHKAFKLKSLLTSHLQRHSGYKPFQCESCSYACFTQYRLQQHMKQHNKEVKREIGYVCPVCEKGFSSQAMFNTHVTSAHNAIL
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDIIQLVLFSLLGSLLVDGSTKANGNKHVKTIIGAIVDERSRIGKEERIAMEIAVDDFNSTSNQSFILHIKDSRGEPFNAALAAQDLINTQEVQVILGPQTWEEVSLVADISSQNSVPLLSFADNIPKRGAERWPFLLQASPNKYAQMKAVAAIVQSWNWFRVTVLYEDSMVDGVIPHLYDALRDVGAEISRVIALSPFDSSSSSSLSEDLEGLKQEDCRVFVVHASLSLAVRLYERAKEMNMMEEDYVWITTDPFTSLVHSINSSIISSMQGIVGVKSYLPEAGQYFQDFYNRFRSRFNRQYPEENNSDPGIFAVQAYDAIRMVALATHEGNYRGKDLLERVLLTDFHGLSGKVQFINMKAAPAYRFQIINVVGKLSYRELGFWSNGLGFSKTIDDGATRSSSMDDLGPVIWPGGSRHTPRGWSLPTSSNPLKIGVPAGSGYKEYVKVENSLGNKPSFTGFAIEVFEETLKRLPFNLPYNFIPFNGTYNELVEQIHLKEFDAVVGDVAIVSNRYQHAEFTHPYTETGLVKIIPTRPTSCSAWLFLKPFTKLMWVLIAAINIYNGFVVWLIERNHCPELKGSIANQIGVLFWLSFTTLFSLHGEKLHSNLSRMSMVTWLFMALVITQTYTANLASVLTVRRLEPDAVNANAMVGYCRGSFVQRYLVEVLNYQPQRLKNYTTIEEYGQALKSKEIAAAYLEAPLANLFLAKYCKGFAKVGPTYKVGGFGFAFRRGSPLLASMNKALLEVSESGKLLELEDGIIVSNDQCKDMELEDENPSLGPGCFRVLFIITGGTSSIALLLLILHKVDSVFKHTSMWKFMWDVLKHLSFPRNRFVRKVSDSEIHGNTFSNTSNTQSGIQIC
The following text describes a protein:
Function:
Ap4A phosphorylase catalyzes the phosphorolytic degradation of bis(5'-adenosyl) tetraphosphate (Ap4A) into ADP and ATP. Can also use other Np4N' nucleotides (where N and N' stand for A,C,G or U) as substrates, but prefers A-containing substrates. Cannot catalyze the reverse reaction. Additionally, this enzyme can also catalyze the phosphorolytic degradation of adenosine 5'-phosphosulfate (AMPS) into ADP and sulfate, the reversible exchange reaction between inorganic phosphate and the beta-phosphate of a nucleoside diphosphate (NDP), and the synthesis of Ap4A from AMPS plus ATP.
Miscellaneous:
MISCELLANEOUS: Present with 1770 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MIEENLKQKIHDKFVAAKKNGHLKVTHAESKKLKDPQTTTQYWVTFAPSLALKPDANKNSDSKAEDPFANPDEELVVTEDLNGDGEYKLLLNKFPVVPEHSLLVTSEFKDQRSALTPSDLMTAYNVLCSLQGDKDDDVTCERYLVFYNCGPHSGSSQDHKHLQIMQMPEKFIPFQDVLCNGKDHFLPTFNAEPLQDDKVSFAHFVLPLPESSDQVDEDLLAMCYVSLMQRALTFFQDWTNESPELTKSYNVLLTKKWICVVPRSHAKSGPPLMLNINSTGYCGMILVKDREKLENLTEDPHLVDKSLLQCGFPNTAGQKPTEYHY
The following text describes a protein:
Function:
Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Required for normal glycan strand length distribution. May function as a terminase for both classes of peptidoglycan (PG) synthases (aPBP and SEDS-bPBP synthases) by cleaving PG chains as they are being actively synthesized.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Note=Access to the inner membrane is important for in vivo activity.
Sequence:
MKKVLLIILLLLVVLGIAAGVGVWKVRHLADSKLLIKEETIFTLKPGTGRLALGEQLYADKIINRPRVFQWLLRIEPDLSHFKAGTYRFTPQMTVREMLKLLESGKEAQFPLRLVEGMRLSDYLKQLREAPYIKHTLSDDKYATVAQALELENPEWIEGWFWPDTWMYTANTTDVALLKRAHKKMVKAVDSAWEGRADGLPYKDKNQLVTMASIIEKETAVASERDKVASVFINRLRIGMRLQTDPTVIYGMGERYNGKLSRADLETPTAYNTYTITGLPPGAIATPGADSLKAAAHPAKTPYLYFVADGKGGHTFNTNLASHNKSVQDYLKVLKEKNAQ
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
Sequence:
MGLGGGGGEGVLAVVPMEAIPMAEPQIVAGGKIVGLRADLLDCHNCRLPLKPPIFKCDAEHLVCSSCRGLHGEACGGRAAVHSALADIFAAAATVPCGYERYGCDAGGVVYHEAADHRRACQHAPCCCPDRAGAAGIGGCGFVGSRQDLLDHISGPDHSRPIIVVRYGQPWNLSLPLSRRWHILVGEEDKAVAAAAGAERHRNLFLVSLGERGATTAVSLVCVRVDGTAPSAPQFACKLAVESDGCRLTLESPLVCSSSLSGGLPAEVKCLPVPKDFLSGDSVPLSIHIEKLPAPPAPPLGLGVAPACTSPVAATPPPCPAATIPPSRPSSGSSDNVAVKTVITDQSYKKRKSANPRKL
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MAGRRISKSLIDWAAFAERVPPHQMDYFRAFKSKSDLFVSKVHRYPENIPKIDFAFYKSRIANTALVTEFERAYSAVSVPFPKDKNNLRAVVDEEEKEAMAESKKLIENAQKTISESKDLLAKIDSVPHLEEMTVDLHAYYFPDDAHNPEKPAFWPFTKSYQPENDPHTIK
The following text describes a protein:
Function:
Metalloreductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLFARLVLLLVYLAPGSLAKPASTKKRTQWDQIAIDACAKELESHKFDTDVKGRHATLCTYEPALGSWLHCAKDVLDSRKKSKKIFEKTFSKINQYCHDYHKDEVVSNEEYYRIFANASLFIRPLDEVKENIRYPVTPNKASLDRWVWAYFGPLDNIDKGNVYGVTICLYWIGVLFIAAVYHFLNFSRLKQTVFKNKVSAFLRGHYVLPALVHNHAMSVGRWFFIGLVPTRLETLVLFGYVLLHGFLLSSYNFDHNELLSDRRSQVLIFLSDRAGILAFAHFPLIVLFGGKNSTMTWLTGIRYTAFITYHKWLGRFMLVDCTIHAIGYTYHAYIENYWKYVKYSDLWTSGRHAMIIVGILVFFSFFFFRRHYYELFVITHIILAIGFFHACWKHCYKLGWGEWIMACALFWIADRILRLIKIAIFGMPWAKLKLCGESMIEVRISKSSKWWKAEPGQYIYLYFLRPKIFWQSHPFTVMDSLVEDGELVVVITVKNGLTKKLQEYLLESEGYTEMRVLAEGPYGQSTRTHLFESLLFIAGGAGVPGPLSMAIKAGRQVKSNDSHQMIKFVWSVRNLDLLEVYRKEIMVLKELNIDTKIYFTGERKDESNTEEGAIANMSTEGRLLTTSKSAEMITDFGRPNIDEIIEEAVSGAKSLLVTCCGSEGFVDKTRELTAKRVLEHGDKWIEYVEEFQNW
The following text describes a protein:
Function:
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.
Subcellular Localization:
Nucleus.
Sequence:
MSVETERSSTESSAASGLDFEDTALTLRLPGSSSSSSSSSSSSSSSSPSEPDRKRASATDDDPDNRLGSTATESPPSPKARVVGWPPVRAFRKNALAALAAASSSKAKFVKVAVDGAPYLRKVDLEAYRGYDQLLAALQDKFFSHFTIRKLGNEEMKLVDAVSGNEYVPTYEDKDGDWMLVGDVPWKMFVETCQRLRLMKSSEAVNLAPRSA
The following text describes a protein:
Function:
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MHFRRRKRLQWNRILFLVSAMFLCSLYQLSVNHNVGAGPWTETELEDHISVREIQEKELISMSVRDLGNQSITTTTSTSTSTPTTEKIRERTKIRHCVDVEPDPITPPIKPRPTTTVTTTTTEKTKSPTKPPLPHAKGEYPEDLFSIEERRRGWVSLHIFGMMYVFVALAIVCDEFFVPALGVITEKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLIMLIIFFLDNVIQWWESMLLLLAYGLYVGFMKLNVQVERLVKGQLSKQRRLVKVMALEDTSKKGNGAVAQDEPKPVEDNNRLRLKPFLTRGGSSASLHNSTMRSTIFQLMIHTLDPLGEASNLNQCRPCYPENGAKFKDKAEIMNNLAKAKVETEAKKGLKAKDDKDETDVPNTVNVEVTPPTGSEPSGDAEDEVMDKDDIKRGRGEGGGGGDSSGSSGDESDDDSDDEDSDDDDDDDDDDDDDDGEGEEEEEADEPLSLEWPETKRKQITYLFLLPIVFPLWLTLPDVRTPKSRNYFVLTFLGSIMWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWFLFSVFNGFSPVPVSSNGLFCAIVLLFLMLLFVIFSIAACKWKMNKFLGFTMFILYFVFVIVSVMLEDRIIVCPISI
The following text describes a protein:
Function:
DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MASERCEDAITEAENNGTSQASSKSIQKSPRPNACTVTPFVTELMSNSRSKRPNSFPTSSPPPKKIANSNPFFPGSAGLGVYLSDPSSHPASRVIYHTPLFVAIHDLYPKSSVHTLLIPREEKWYNMHPIAALSNPEFLEMVRPEAEKLKGIVASELRRRYGSESAQDMEREKILSGEVNLEDDAEMPDGRDWKRDVMVGIHMHPSMEHLHIHVLSVDRYSSCMRKRKHYSSFATPFFVNLSEFSLSEERQEALSRSGQAKAWLQGDMKCWSCGLNFGNKFAKLKEHLELEFIEWKKK
The following text describes a protein:
Function:
Metal transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYSLDGFSKDSIELNETQHFQLFGEEVTLVKRAFLSFDAVCHVEAYPLKMVSVNRAEKRYDWNHIREFRMDQEMRSQDERINFFFCTEPRATEFSQMVTITEGQDFQMVYLMMPLLALCLIMSATFSGLNLAIMSFSINDLKLIQGSDSNLRNRQRAGDVLRLRRHSNYVLVTIIFGNCFCNTSITLLLNYFGDVYGFGEFGYVELTATILLLIFTEILPSLIFTKNALPIASGMQYFVIFAMIVTMPISYPLSKLLDRILGKENADEAAPMEVDSVQLVAMIDEKLDDGEVGMMNVVQRALDLRKKRAEDVMTPITEVEVISEDMVITKEFLTDSFDRGFSRLPVHDKDNENKICGVLNLFDAMLLMDDQGRGLTTDLTAGTLLSVLEKRRKHCFVLNSLPVQQFMVELQRGCTMAIVVQYLGDKSDVDAEERLEELEKKELEKLKAKEETYVEVEEDESEREKEKMAKALRRESYQVIGIITMEDYMEEVIGEIMDEKDKKEVKTK
The following text describes a protein:
Function:
Part of the tripartite efflux system MdtEF-TolC, which confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzalkonium.
Subcellular Localization:
Cell inner membrane; Lipid-anchor.
Sequence:
MNRRRKLLIPLLFCGAMLTACDDKSAENAAAMTPEVGVVTLSPGSVNVLSELPGRTVPYEVAEIRPQVGGIIIKRNFIEGDKVNQGDSLYQIDPAPLQAELNSAKGSLAKALSTASNARITFNRQASLLKTNYVSRQDYDTARTQLNEAEANVTVAKAAVEQATINLQYANVTSPITGVSGKSSVTVGALVTANQADSLVTVQRLDPIYVDLTQSVQDFLRMKEEVASGQIKQVQGSTPVQLNLENGKRYSQTGTLKFSDPTVDETTGSVTLRAIFPNPNGDLLPGMYVTALVDEGSRQNVLLVPQEGVTHNAQGKATALILDKDDVVQLREIEASKAIGDQWVVTSGLQAGDRVIVSGLQRIRPGIKARAISSSQENASTESKQ
The following text describes a protein:
Function:
3'-5' DNA helicase that may play a role in the repair of DNA.
Subcellular Localization:
Nucleus.
Sequence:
MDFDSDSDGSHVSATPPRDSFPSSPPQLQSPAKHVPPVSRKMTSSSSRSKPKAPTHPPPNPSQEAPVPSPYPPPPPPSPLFTNLPFRICQSQPARFSSSVSSFSRLCSRASFTSVEKLKSDGVDFVPEPPLVEVIAPPKSVRRKPPNLITDTITSPPVKPMVFRSNGNGEGNFVKLNLNGKRGKKFPSKYKGVSKSRSSYSFRGKRYKKKEADGDGESLLEEESDLQKQIEDEANGFISSVEDAILAVKTEASDENLTKLLNLVYGYDSFRDGQLQAIKMILGGSSTMLVLPTGAGKSLCYQIPAMILPGITLVVSPLVSLMIDQLKHLPSIIKGGLLSSSQRPEEATETLRKLKEGIIKVLFVSPERLLNVEFLSMFRMSLSVSLVVVDEAHCVSEWSHNFRPSYMRLKASMLFSELKAECILAMTATATTMTLQAVMSSLEIPSTNLIQKSQLRDNFELSVSLSGANRMKDLLILMESPPYKEIRSIIVYCKFQYETDMISKYLRDNNINAKGYHSGLPAKDRVRIQESFCSNKIRVVVATVAFGMGLDKGDVGAVIHFSVPGSMEEYVQEIGRAGRDGRLSYCHLFYDNDTYLKLRSLAHSDGVDEYAVGKFLTHVFSTETKQHEKICSLVIESASQKFDMKEEVMQTILTHLELGEVQYLRMLPQLNICCTLNFHKSSPNTLAARSAIVAAILKKSHVKQGLHVFDIPAVASSICVATTDVLAEIQALKMKGEVTYELKDSAFCYTILKSPKEICSLSSHLTKWLTEIESCKVRKLDIMSSAAVAAISVSNTSELSSGAKQTRSLQSRIFDYFNGDEKCDSPSKATQNCAFLRADIKVFLQSNRQAKFTPRAIARIMHGVGSPAFPNSVWSKTHFWGRYMNVDFRVIMEAAQTELFNFVDRNAALAT