lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Degradation of glucosinolates (glucose residue linked by a thioglucoside bound to an amino acid derivative) to glucose, sulfate and any of the products: thiocyanates, isothiocyanates, nitriles, epithionitriles or oxazolidine-2-thiones.
Subcellular Localization:
Vacuole.
Sequence:
MENGDKACDGYHKYKEDVQLMVETGLEAFRFSISWSRLTPNGRGSVNPKGLQFYKNFILELVSHGIEPHVTLYHYDHPQQLEDEYGGWLNRRIIKDFTAYADVCFREFGNHVKFWTTINEANIFTVGGYDGGNTPHGRCSTCLSGNSSTEPYIVAHNLLLDHASASRLYRQKYKDTQGGSVGFSIFAIGFRPSTNSKDDEMAIQRFKDFFFGWMLGPLTYGDYPEGMKRILGTRLPVFTKKESEQVKGSSDFVGVIHYLAASISNAQSQPSLPGNSAFFTDIGASLTYSGNFSAFEYEVAPWAMEVVLEYIKQSYGNPPVYILENGKPMKQDLQLQKKDTPRIEFLDAYIGAVLKAVRNGSDTRGYFVWSFMDLYELLSGYKFSFGLYSVNFSDPHRNRSPKLTAHWYSAFLKGNTTFLGSQGITQCAMLKLETHSGPRNVESDHARIVEVVPHVDADLKHTAAKVVEKAKGICESKSEDDLHHRELSNHHYSRKEEGRDLSRTSHRSEPQEKRGRSASGREESISGPVPRNPTARGIPLQSDKVPATQTIFDEAVEEVREAMIQYTQCADPTESAARRERLRLAEEKGELEEAASLMIQARLETENGTLTGNPREEEELPLTERIPATLRLGPMAPLSLYDEEGPSAERIPAALRLGPVEIPQNRTAMQITTTKEKRKPGRPPAKKRTITSPQGTKASSSRKRKIQQAKPPPARRRLLAEPEKGQTSRARADKPRSSRKTTRTTTSSANSDDQPICNMIPRATRRKMDFQDPSHLVP
The following text describes a protein:
Function:
The specificity (S) subunit of a type I restriction enzyme; this subunit dictates DNA sequence specificity. The M and S subunits together form a methyltransferase (MTase) that methylates A-2 on the top and A-3 on the bottom strand of the sequence 5'-AACN(6)GTGC-3'. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated. After locating a non-methylated recognition site, the enzyme complex serves as a molecular motor that translocates DNA in an ATP-dependent manner until a collision occurs that triggers cleavage.
Miscellaneous:
MISCELLANEOUS: Type I restriction and modification enzymes are complex, multifunctional systems which require ATP, S-adenosyl methionine and Mg(2+) as cofactors and, in addition to their endonucleolytic and methylase activities, are potent DNA-dependent ATPases.
Domain:
Contains two DNA recognition domains, each specifying recognition of one of the two defined components of the target sequence.
Sequence:
MSAGKLPEGWVIAPVSTVTTLIRGVTYKKEQAINYLKDDYLPLIRANNIQNGKFDTTDLVFVPKNLVKESQKISPEDIVIAMSSGSKSVVGKSAHQHLPFECSFGAFCGVLRPEKLIFSGFIAHFTKSSLYRNKISSLSAGANINNIKPASFDLINIPIPPLAEQKIIAEKLDTLLAQVDSTKARFEQIPQILKRFRQAVLGGAVNGKLTEKWRNFEPQHSVFKKLNFESILTELRNGLSSKPNESGVGHPILRISSVRAGHVDQNDIRFLECSESELNRHKLQDGDLLFTRYNGSLEFVGVCGLLKKLQHQNLLYPDKLIRARLTKDALPEYIEIFFSSPSARNAMMNCVKTTSGQKGISGKDIKSQVVLLPPVKEQAEIVRRVEQLFAYADTIEKQVNNALARVNNLTQSILAKAFRGELTAQWRAENPDLISGENSAAALLEKIKAERAASGGKKASRKKS
The following text describes a protein:
Function:
Transcription factor required for yeast cell adherence to silicone substrate.
Subcellular Localization:
Nucleus.
Sequence:
MAAQKKYICAFCARAFTRSEHKQRHERSHTNEKPFHCLHCTSSFVRRDLLQRHCRTVHHTNLNPSTLPSNKSLKNPTTNPLDLSNNEGTTTTTKTGNRKNNSNKNGAKNDKSTNPNPAVSNDDNRSSVGDITTQLPFQVQFNTQLPYQQQQQQQQQQQYPILQNQGIPMKQSFSMESDQHSLTTFDSPTSSLGVSMTPSGSTNSEIVLQQQQQTTKRRKRSQENNSNNNTKLIAKELNHDLVHLLSITKKLTTLLQHYDNVKVNITDSFLIGYVHIQQQAKNFTIFEKILKDLVYYLNTYHINNLQQQNQFPPSQQQNHYTINHFKIGISYCVIALGFLIDHKPNRAIQFFKKSWNLLIKTLIPQYNSNNNLLDQIEILYNLFLLCYIYLQFNLETFDINEKQHEHHSYEQGDEHEDHHQEQVYINNQVILNYLNDISFIIASNLKDVATNNLIDHNLNLFWNIYILLSSYITKEPPKIHQILLNKNLKQNDTLVSLMQKFSKSFINMDMDDEQLKLVVVAALNNELKLYFNDTVDEFEPENSKNKRKFIYDNRNVLHNAIILINKSINFYNPSASLVNDAKMFELKLFELFKKNLIINSPMKYHELFNNYIFIPQHYYHWQLLTLTLKEINQNNVIFNQIHSILTTTTGSNVCFSFIDFENLLKNSFLNYKANPIVINNNLLIISYPIIILSNYLNLDNLMTSMGQMNQLQFINLNIFIIEWYLIMMKVLIIIWDDTLIDFEDNYILQTLMYILLDNKSCLLKRLNIDTSKLEYDVNCERLSFNQKWFWIIKLKFDSIFENWMNFLKNKNNNVTNNSNVTNTSTTGITNTNHNHNDSYLHHFNVNVSNFKFNLNKYLNEYFVTGDFKFREQLDQNDPDQFQGSMSMDEEPDFTTAMQTSQTINSFMPIHNHNSRNQVYQQHNQDTPMTSRRDSTNINENNIAQTSSFISNSNYQGSNSNNMINYNEFQDRNYKRSSSITLGILAQTV
The following text describes a protein:
Function:
Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. May be involved in lateral roots and nodules formation.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein.
Sequence:
MVSTSPSKEHQSIEKWTEGDPSRRAKWWYSTFHTVTAMIGAGVLSLPYAMAYLGWGPGTMVLALSWCLTLNTMWQMIQLHECVPGTRFDRYLDLGRHAFGPKLGPWIVLPQQLIVQVGCDIVYMVTGGKCLRIHGDDLRYLHTDQALPNFNSVAGVSLAAAVMSLSYSTIAWVGSLAHGRVDNVSYAYKETSGADHMFRVFNALGQISFAFAGHAVVLEIQATIPSTPEKPSKVPMWKGALGAYFINAICYFPVALIGYWAFGQDVDDNVLMALKKPAWLIASANLMVVVHVIGSYQVYAMPVFAMLENMMMKRLNFPPGLALRLLVRSAYVAFTLFVGVTFPFFGDLLGFFGGFGFAPTSYFLPSIMWLIIKKPKRFSAKWFINWASILVGVFIMIASTIGGFRNIVTDASTYRFYT
The following text describes a protein:
Function:
This enzyme catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.
Sequence:
MKKRLLVSFLVLSIIVGLLSFQSLGNYNSGLKIGAWVGTQPSESAIKSFQELQGRKLDIVHQFINWSTDFSWVRPYADAVYNNGSILMITWEPWEYNTVDIKNGKADAYITRMAQDMKAYGKEIWLRPLHEANGDWYPWAIGYSSRVNTNETYIAAFRHIVDIFRANGATNVKWVFNVNCDNVGNGTSYLGHYPGDNYVDYTSIDGYNWGTTQSWGSQWQSFDQVFSRAYQALASINKPIIIAEFASAEIGGNKARWITEAYNSIRTSYNKVIAAVWFHENKETDWRINSSPEALAAYREAIGAGSSNPTPTPTWTSTPPSSSPKAVDPFEMVRKMGMGTNLGNTLEAPYEGSWSKSAMEYYFDDFKAAGYKNVRIPVRWDNHTMRTYPYTIDKAFLDRVEQVVDWSLSRGFVTIINSHHDDWIKEDYNGNIERFEKIWEQIAERFKNKSENLLFEIMNEPFGNITDEQIDDMNSRILKIIRKTNPTRIVIIGGGYWNSYNTLVNIKIPDDPYLIGTFHYYDPYEFTHKWRGTWGTQEDMDTVVRVFDFVKSWSDRNNIPVYFGEFAVMAYADRTSRVKWYDFISDAALERGFACSVWDNGVFGSLDNDMAIYNRDTRTFDTEILNALFNPGTYPSYSPKPSPTPRPTKPPVTPAVGEKMLDDFEGVLNWGSYSGEGAKVSTKIVSGKTGNGMEVSYTGTTDGYWGTVYSLPDGDWSKWLKISFDIKSVDGSANEIRFMIAEKSINGVGDGEHWVYSITPDSSWKTIEIPFSSFRRRLDYQPPGQDMSGTLDLDNIDSIHFMYANNKSGKFVVDNIKLIGATSDPTPSIKHGDLNFDNAVNSTDLLMLKRYILKSLELGTSEQEEKFKKAADLNRDNKVDSTDLTILKRYLLKAISEIPI
The following text describes a protein:
Function:
Involved in the transport of the cationic amino acids (arginine, lysine and ornithine).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MARGLPTIASLARLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGMVGSGLYVLTGAVAKEVAGPAVLLSFGVAAVASLLAALCYAEFGARVPRTGSAYLFTYVSMGELWAFLIGWNVLLEYIIGGAAVARAWSGYLDSMFSHSIRNFTETHVGSWQVPLLGHYPDFLAAGIILLASAFVSCGARVSSWLNHTFSAISLLVILFIVILGFILAQPHNWSADEGGFAPFGFSGVMAGTASCFYAFVGFDVIAASSEEAQNPRRSVPLAIAISLAIAAGAYILVSTVLTLMVPWHSLDPDSALADAFYQRGYRWAGFIVAAGSICAMNTVLLSLLFSLPRIVYAMAADGLFFQVFAHVHPRTQVPVAGTLAFGLLTAFLALLLDLESLVQFLSLGTLLAYTFVATSIIVLRFQKSSPPSSPGPASPGPLTKQQSSFSDHLQLVGTVHASVPEPGELKPALRPYLGFLDGYSPGAVVTWALGVMLASAITIGCVLVFGNSTLHLPHWGYILLLLLTSVMFLLSLLVLGAHQQQYREDLFQIPMVPLIPALSIVLNICLMLKLSYLTWVRFSIWLLMGLAVYFGYGIRHSKENQRELPGLNSTHYVVFPRGSLEETVQAMQPPSQAPAQDPGHME
The following text describes a protein:
Function:
Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.
Sequence:
MAAQGVGPGPGSAAPPGLEAARQKLALRRKKVLSTEEMELYELAQAAGGAIDPDVFKILVDLLKLNVAPLAVFQMLKSMCAGQRLASEPQDPAAVSLPTSSVPETRGRNKGSAALGGALALAERSSREGSSQRMPRQPSATRLPKGGGPGKSPTRGST
The following text describes a protein:
Function:
Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGVKSKKKAKTRLDAYYRLAKDQGYRARSAYKLIQLNRKYDFLAKSRVLVDLCAAPGGWCQVAAQHMAIGSKIVGVDLVPIAPIRGVKTFVGDITDDKTRKMIVTYLKKEPVDCVIHDGAPNVGGVWSRDLFDQNALVLASAKMACSMLKANGWFVTKVFRSPDFHNLLWVFKQLFEKVEATKPQASRMESAEIFVVCAGFKAPKNIDPAFFNPQKVFAEVGQEKIVSASGMLVTPKSNVPTGYEEFATVSHHVASFSDFLNADDPKGFLKTHHELRFSDDADKEYLTSKSSKKELVYLCGDLQQVGEADLRRMLRWREQLLREKIHRIQVDAAGTEEDGDVDSMAGGNGSDDDDDDDGEGKRDYHFDFDSPEGVTQIARELLEIRKKKAKELKKKQKKVVDRKLKQIKGLINYDPNMSAEHMTETDGFAYKGTNTDAFDDDGDAAAGGEDGEADELDHFTVEQLGLIPEKELAHIMDKTWIEPEDRGNDPLNPVMSVNLAAQDDWDLGDKKDGDESEAEGDADGVLHSTQLVEGEEHFMDVDNYGNYVPAQRSTRVTLYEAGLEGYEDSNDAEAADETPVSKKKRAKTEKDAAQLDEAGKSSKWERHQLNIEKVLNDTFPKPKDHDRAKNKKQQRTLEEERIIMSAPTEMADPDKRKHVRTRFENKDNDDDSDDSVSELSAELSDGDLDDYEINRGREDSRRKRKLIPDIGKVTTQELIRQQRKQTLCDNKEVRKQNKRNKNNANSGRNSSGKQDTEFEEIPIAMTDPDIRARTLAIAQKMLDPKARREILDASVNRYVFNDDDDLPDWFVKDEQRNCRVVLPVTAEEIEEQRRRFRELNARPSRKVMEAMGRKRRKAQRMLRSLIDKGKADPRAREKAENLSVRKLMRSQVVKGQGKKRHKYLDRQLMGRMRREKQKLKRRK
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKRAAAKHLIERYYHQLTEGCGNEACTNEACGSSPGFQRMDNNAAAIKALELYKNNAKLCDPHPSKKGASSAFPENSAKGAHNFSACSNGKMNHKDLPPTREDFRDLNFLTEDKVYEILSICSETEDYSPLIRVIGRVFSSAESLVQSFRKAKQHTKEELKSLQAKDEDKDEDEKETASGSSTAMEVEPEASASSGDGSSHGENNVQKLGPVEVSVDIDAVRRVYDRLLSNEKIEAAFLNALVYLSPNVECDLTYHNVYAADPNYLNVFIIVMENSNLHSPEYLEIALPQFCKAMSKLPLPALAKLARLWSQYGVDQIRRLVETFQQLITYTVISNEFSSDNLVNEDDGVVAATKCLKIVYYANVLGGDLDTDHNEEDDDEPIPESSELTLQELLGEERRNKKGPRVDPLETEMGIRASDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETESKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITALYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFENEGQFTLIGIVLGLAIYNNCILDVHFPMVIYRKLMGKKGTFRDLADSHPVLFQSLKDLMEYEGNVEEDMMITFQISQTDLFGNPLMYDLKESGDKIPVTNENRKDFVALYAEYMLNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEESTEYDGGYNKDSRIIRDFWETVHSFEQEKKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDSDRLPTSHTCFNVLLLPEYSTVEKLKERLLKAITYAKGFGML
The following text describes a protein:
Function:
Involved in vesicular recycling, probably as a GTPase-activating protein for Rab family protein(s).
Subcellular Localization:
Cytoplasm, cytosol.
Domain:
The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.
Sequence:
MWLKPEEVLLKNALKLWVTEKSNDYFVLQRRRGYGEDSGGLTGLLVGTLDTVLDSTAKVAPFRILHQTPDSQVYWTIACGASLEEISQHWDWLQQNIVRTLSVFDSGEDITSFVQGKIRGLIAEEGTSAGDEEDPERFREAVLRFERLFGLPQREKLVTYFSCSYWRGRVPNQGWIYLSTNFLCFYSYMLGNEVKLVYPWDEVSRLERTSSVLLAESIRVRVRGEDHFFSMLLRLQQTYLIMQQLADYAIVRFFDKETFHAEHPLANPLHITQRALEIHARNQSFRSFFRLPQEENLCEVYESFLWVPFSHVNTLGKICVSENYLCFASQDGSQCHLIIPLWEVFSVELPDRSSRALTVCLRGKRALRFSEVRDFERLAATIRRKCGTLGSPQHCITNPDEEGVMVGQSQAVSTEALMNVFHPHDAENLDPKMLKERMKEQSWQIHFAEYGRGTGMFCTKKTRDLIVRGVPETLRGELWMLFSGAVHDMISHPGYYGRLLEDCMGSSSLACDEIERDLHRSLPEHPAFQSDTGISALRRVLTAYAHRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGALVDQAVFEELIREHLTQLTEHMTDLSFFSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAVLDYNMDNLLCCNDDAEAVTVLNRFFDSVTNKDSPLPATVQQASATANDKSIQKVDISDLIKEAYEKYGDIRTEEVENMRKRNKLYVIQTLEDTTKQNVLRVVAQDVKFSASQLDELYLLFKNHDPSLPYLDQYQLDQSQFSSLFNLLQPWTTHTHSRSLARSAFHLLDENGDGLVNFKEFICGLDILYNRSFTEKLKLLFKLHLQPDSAEDGVIRKCPERGRAKVDLQEYLKQWQEDLQRREENIKDLPRINQVQFISLTKTLYSVFHGDEEEESLYRAVARVTSLLLRMEEVGRKLQDSSPQKTPQTTPTSTSQPESSPTKPTSPESETPAESRSTHDQPESPVSQHETAPSHSDITPNSTSHPSTPTSSPTETSSPVLDTPTDTPSSPCTVRDGDWSFSFEQILASLLNEPSVVRFFERVVNTDTLITRARKNQLKDAH
The following text describes a protein:
Function:
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
Subcellular Localization:
Cytoplasm.
Domain:
The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.
Sequence:
MAKRDYYEVLGIDKSASENDIKKAYRKAAMKYHPDKFANASDAEKKDAEEKFKEINEAYQILSDSQKKQQYDQFGHAAFEQGGAGFGGGFNAGGFDFGDIFGDIFGGGGFGGFEGFSGFGGSSRRSYVEPGNDLRYNLEITLEEAAKGVEKTIKYKRTGKCENCHGTGGEDDKMKTCPTCNGQGTIRTQQRTILGVMQSQSVCPDCHGTGKVPEKKCKHCHGTGTAKETVEKKVNVPAGIDDGQKLKYAGLGEASQNGGPNGDLYVVIRIKSHDIFVRDGENLYCEVPISYSTAVLGGEVEIPTLNGKKMIKVPEGTESGKLLKVKGEGIKSLRGYGQGDIIVKITIETPKKLTDKQKELLQKFEESLNEKNYEQKSSFMKKVKKFFKDIID
The following text describes a protein:
Function:
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. May be important for growth and survival.
Sequence:
MADILKSVKRIVVKVGSSILVDNQEIAAHRIEALCQFIADLQTKYEVILVTSGAVAAGYTKKEMDKSYVPNKQALASMGQPLLMHMYYTELQKHGILCAQMLLAAYDLDSRKRTINAHNTIEVLISHKVIPIINENDATALEELVFGDNDRLSALVAHHFKANLLVILSDIDGYYTENPRTSTNATIRSVVHELSPDDLVAEATPNNRFATGGIVTKLQAAQFLLERGGKMYLSSGFHLEKARQFLLGGSHEIGTLFYSRVSS
The following text describes a protein:
Function:
May have a role in DNA double-strand break repair following gamma-irradiation.
Subcellular Localization:
Nucleus. Note=Localized to the nuclei of proliferating germ cells.
Sequence:
MASSSNTMEFEEDDSTVTQTSLPTTTSVLDKSRSLFGNSAVISTPARDSTPDGHIVDSSVITKSSVIIEAEDEPDVAADVTALDKEKAEDEPQCSAGKDAKSGESMNDSEKSESPIEEGEGETFEKKIISMDTSDDKLDIAESISVSNDTEKPEENEEKVVGDEDEEDIDDVQEDDEDEAPKKKTKKAVSTSDDDDLHEDDSPKGGSVSDEKEEPENEDDTEEPENEVEVESPVKEQADSGEPIENVNDDKASEPGVGEISQDSVDDSQKIGLDSKSPDGESEANEENQESQSSSRSTRRAKRVSATVSSTPSSNTPRRGGRGQKSEVNADETKTPIVSNSTPRRGRSSRGGDRDEVIDPTENVVGDSGVEETSPRKGRSRRSVATEDTSVTEEVENTEHPTEEETPKQGRGRRSAASSSATSSAVPTPRSTRGRGRKSQANEENLQEKETEDPTKTHDTNQAKSTRTPRGRRSNADAETMESVEAEKVETPTSSRRSTRAKPPAKSAPVTPAVTNKRTTVRGRKKQGSITEDPIEEADETIEETLPQKKGRGAAKSAPSSSKKSAEYDPYDLDTEMEHHPEPLKNIHMEVHNFGAVKYAKLGNSESKYSMTEKAAESRIAELQSSPAAKNRRSLADMTPGKDKMKHRVSSVGTSGRRSRAKKEEEHHENDIEMEDAPATATPASSNRGRKRKSEASDIKTPPAKKEPVIPLKNLSDEDQLLVDHPQDDNEPHAPGARVYAVFQKMFYPAVVLSERDGLGRYKVQFTVDNVIKDVPNSGIIPLRALSPGKTAVYNESDVRLDSGPNDISAAEWKKGKLTISIMDEDGEPTDEVKVVDWYDVSFDHSEWRDYVKSKDQSATAIVTSNITTISEATRARKPTTVSNQAKPKGRKKKGVDLVSSRGGSASPAEEEEKLLPMNEEAIGKNIFTGKVFMLTSANRSNSASVPSMFKKKNLMNFITQNGGIVTEQLNSFQERYSNYEPLLISDTYYRTHKYLAALARGVPCVNNTWLQACGEQGKCVDYTDYVLPAGASIFDESQDMPAPKNPSELLKGTTIYVHSTHSAREVTQTGPGGTFIEIWKPILELLGADVVDGDWETLDETGLKFDVVLVDGTFRDEVMEYADTIGASRVTSEWVIQTIILGKAPEPNAHPKFDPYRLHHRTRH
The following text describes a protein:
Function:
Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins.
Subcellular Localization:
Nucleus.
Sequence:
MAAYPESCLDATVLNFVADLSLASPRHPLLCEFPPGVPFGDRTLGYREGRPGRLSQFDERYQEVEGDEVEYEDPEEEEEEGEGRGRVASLLGRPKRKRVITYAQRQAANIRERKRMFNLNEAFDQLRRKVPTFAYEKRLSRIETLRLAIVYISFMTELLQSKEEKEAS
The following text describes a protein:
Function:
Antimicrobial peptide.
Subcellular Localization:
Secreted.
Sequence:
GLWKTLKDSAKSAVTNVAVTMLDKLRCKLTGGC
The following text describes a protein:
Function:
Probable sugar transporter.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
Sequence:
MNLPERSRFVIYAVGIFVCYFLYGIVQEKLTRGRYGEEVQTDGSVGERFTYALALVWVQCLCNYVFAKVLLTIRPQKEDTTNAGSYVACSLTYLLAMVSTNMAMRWVPYPTAVVGKSAKPIPVMILGVLIGRKSYSWTRYACVLTIVLGVILFMYKEGKVSNLPAETTLLGEVLLFLSLSMDGLTGAVQERIRAASAPSGQQMMRAMNFWSTLMLGVAMVFTGEAKEFMYFTIRHPEAWTHLSLIAVCGVLGQFFIFLMVASFGPLACSVVTTTRKFFTVLCSVLLFGNVLIARQWLGAVLVFAALFVDMLYGKKAPLATAKKPPVEGKLSEEKKLNS
The following text describes a protein:
Function:
Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
VIDARIFALPCTEPRSSARVLSVKLSSDALVGSTLKASPIRIIFQGYDPAKPDPLPEFLLHPRIQTNSSSRIRVGFLGHNEAYCEDNYLVGGYLCRVDWSPGDVCSSTKSDLLPIYFIVSLGCYGLLMVGIGLMHFPTCPQEAVLLQQDIVEAKDFLKQRGVDVSSE
The following text describes a protein:
Function:
TIR-NB-LRR receptor-like protein involved in plant defense. Acts as a trigger of hypersensitive response (HR). Functions as a guard of CAMTA3, a negative regulator of immunity, during pathogen infection.
Domain:
The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Sequence:
MESSSPSSAEFDVFLSFRGFDTRNNFTGHLQKALRLRGIDSFIDDRLRRGDNLTALFDRIEKSKIAIIVFSTNYANSAWCLRELVKILECRNSNQQLVVPIFYKVDKSDVEKQRNSFAVPFKLPELTFPGVTPEEISSWKAALASASNILGYVVKEISTSEAKLVDEIAVDTFKKLNDLAPSGNEGLVGIESRLKNLEKLLSWEDLDTVHIIGIVGMVGIGKTTLADCLYGRMRGQFDGSCFLTNIRENSGRSGLESLLQKLFSTVLNDRDLEIGAPGNAHERFERRLKSKRLLIVLDDVNDEKQIRYLMGHCKWYQGGSRIIITTRDSKLIETIKGRKYVLPKLNDREALKLFSLNAFSNSFPLKEFEGLTNMVLDYAKGHPLALKVLGSDLCERDDLYWEAKLDRLKSRSHGDIYEVLETSYEELTTEQKNVFLDIACFFRSENVDYVTSLLNSHGVDVSGVVKDLVDKCLITLSDNRIEMHDMLQTMAKEISLKVETIGIRDCRWLSRHGNQCQWHIRLWDSEDICDLLTEGLGTDKIRGIFLDTSKLRAMRLSAKAFQGMYNLKYLKIYDSHCSRGCEAEFKLHLRRGLSFLPNELTYLHWHGYPLQSIPLDFDPKNLVDLKLPHSQLEEIWDDEKDVGMLKWVDLSHSINLRQCLGLANAHNLERLNLEGCTSLKKLPSTINCLEKLIYLNLRDCTSLRSLPKGIKTQSLQTLILSGCSSLKKFPLISENVEVLLLDGTVIKSLPESIQTFRRLALLNLKNCKKLKHLSSDLYKLKCLQELILSGCSQLEVFPEIKEDMESLEILLMDDTSITEMPKMMHLSNIKTFSLCGTSSHVSVSMFFMPPTLGCSRLTDLYLSRCSLYKLPDNIGGLSSLQSLCLSGNNIENLPESFNQLNNLKWFDLKFCKMLKSLPVLPQNLQYLDAHECESLETLANPLTPLTVGERIHSMFIFSNCYKLNQDAQASLVGHARIKSQLMANASAKRYYRGFVPEPLVGICYPATEIPSWFCHQRLGRSLEIPLPPHWCDINFVGLALSVVVSFKDYEDSAKRFSVKCCGNFENKDSSFTRFDFTLAGWNEPCGSLSHESRKLTSDHVFMGYNSCFLVKNVHGESNSCCYTKASFEFYVTDDETRKKIETCEVIKCGMSLMYVPEDDDCMLLKKTNIVQLSLKSGPSCSYDLDDVMDDVRPKRGLCQFVGGEEPGCKRRKEEKITVR
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. In addition to the protease activity, also mediates delipidation of PE-conjugated ATG8 proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MSQALSLRKLSELMHGTTSLSQHTICLLGKSYGDAGTGDQSKALDAEALEAMLGDFRSRMWCTYRKDFPALGPSLLTSDVGWGCTLRSGQMLLAEAMMRVALGRDWQRCSDNLEAVRPVVAALLDCAEAPLSIHRICDAGGPAGIVPGRWLGPWMLCKGLEALFSQLAGAQQEPLGLRLHVACGAGGGAPELHMDLIRAAMAPAAQSAATAGTGKAGTGKGSGAGADEGTGDKVGLEAAAGCSTGSAGPLRCERSRSQVEEDVGVACKQPEGCGCAKQEVPVRGLPADLGLEAHDCGHPGHTGTGGDRQVTASGPGGPDDAGQSSAQGHGDREAVAGSRLQGPQRTEGTVAAGQFCSEPCGSPTVADAAVAAPGSAGREIASDTAPEQESASSSTAASSCCGEAEDAAAHGRRCRGVAAGTCGRGHSLLLLVPLTLGMDKINPVYIPQLQQVLSWPQSVGIVGGRPSASLYVCGVQDASFIYLDPHEAQLAVRTPAATAAATAAAAVAAPAGGAAATVRAAAGGGGAGAGGQGGGATAWPPTGWLAAPQLGTYFCDVVRVLPSAQLDPSLAIGFVCTSSAELEDLFARLQALATQHSSAPLMTLTTGSGAAVGCGSDADFTDDVLEGGTGQQQLDEWELV
The following text describes a protein:
Function:
Stimulates smooth muscle contraction. Role in induction of hypothermia, stimulation of DNA replication and release of many gastrointestinal hormones (By similarity).
Subcellular Localization:
Secreted.
Sequence:
QQRLGNQWAVGHLM
The following text describes a protein:
Function:
Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
Subcellular Localization:
Cytoplasm.
Sequence:
MPDMTDDIAEGISFQAFEDDCRLLGSLLHDVLLQELGPGFVHLFERIHILAQSAVTMRGAGMVDTAAVVERQLEAELSAMSLEDSLCLARAFSHHLNLMSIAERHHRVRKSRSEVHLSKSCHDIFDKLIQGGVPPEELYNTVCKQGVEIVLTAHPTQINRRTLQYKHLRIAHLLEFNGRHDLNYEDREMLIEDLVREITALWQTDELRRHKPTPVDEARAGLHIVEQSLWKSIPRYLRRVSNALKKHTGKPLPLTCTPIKFGSWMGGDRDGNPNVTSKVTRDVSLMARWMAIDLYIRQLDSLSFELSIKKCSDKLATLANEILLKDSESTSEEKKASPWTKTGPEKNLKLQPGLGLPAQLPSGADLPSLAECNDSESQFRMVKLPWNPKHQGIQIPTERSEDSHSPVQSPGRRPGSSHMSRTPSGSQLRKMLFTESKIGRSSFRKLLEPSLSDKPGITPYRIVLGNVKEKMMKTRRRIELLLEDLPCDSDPTEYYETPDQLLEPLILCYESLQSCGSSILADGRLADLIRRVATFGMVLMKLDVRQESGRHTEALDAITSYLDLGVYSEWDEEKKLDFLTKELKGKRPLVPPYIEVNADVKEVLDTFRVAAELGSDSLGAYVISMASNASDVLAVELLQKDARLTVSGDLGRECPGGTLRVVPLFETVKDLREAGSAIRKLLAIDWYREHIIKNHNGHQEVMVGYSDSGKDAGRFTAAWELYKAQEDVVAACNEHGIKVTLFHGRGGSIGRGGGPTYLAIQSQPPGSVMGTLRSTEQGEMVQAKFGLPQTAVRQLEIYTTAVLLATLRPPQPPRDPNWRRVMEEISRASCAHYRRTVYDDPAFVTYFQEATPQAELGYLNIGSRPAKRKAAITAAGGIASLRAIPWVFAWTQTRLALPAWLGVGTGLQDARDKGRTEDLRAMYEEWPFFRSTLDLIEMVVAKADAPMAKHYDDVLVPSPDRRALGEELRRELAKAESCVLAVSGHTKLSANNRSLRRLIESRLPYLNPMNMLQVEVLRRLRRDDDNTKLRDVLLITINGIAAGMRNTG
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, flagellum basal body.
Sequence:
MPKKAKKSLGRTEGERLVQLHHRAQAEEEMSKKKEEMLALFLKDKLQKEQRNTAVNLLKVTDRWRSIQRQARVTELRGNIVVSRQMFEREVDELNFVIEKLMGDLQGAERQTAHVQASHLQQLDHLLAQDLKRMGCLHQDWGGGLQDLCSSYSSEKQQMFAQFEEQRDKLQSKVFSADQHHKDAMQEIKKTSTDRESWFSSHSDPKNVQMGLRDNLHESISNILGSWKHNINNVKKKEEEVALLLDYVTQQLKITMRLKNKAEQLRDRVKATEWEKEFMEENLTAYRNEMNLRFYQAQGQVASGRQATRKQLTQLAVQGDAAAEKQQAAIAQGEKVLRAAKMCLKLKLQHEDLPPLFAPLHLPPEEDTQGSEDVQHLQQRLTKAVLQRDALRKHKSDLSQENVQLQLLLGQHSFGLHEDCCPLPTSQAPIISAPAAGQQRHTVIEAAHIAKYCL
The following text describes a protein:
Function:
Involved in the early part of the secretory pathway.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein.
Sequence:
MSAIFNFQSLLTVLLLLVCTCAYVRAIYPSLLDKNKTGILGIFWKAARIGERKSPYVALCCMAMAASILFW
The following text describes a protein:
Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
Sequence:
MADHGFDGYDDPAPAQGYDQPPEYEAQNEDHFNEPLDHAENDFGAAPHHSNGPIMDDAFEPMANGNPLPPPEDLPPEESMVLREWRRKRAAELEEKTRTSQEKHAQILDHAAEDRERFYDQREKQVATSKTTNKEKEKVLLANLDSLMAKAGENYWEAVTGFINFDTQQDKKGAGKGKSATPRQSIVPEVKAGRQTDLARFRQILLKLKHTPPIRHSVAAA
The following text describes a protein:
Function:
GTPase involved in protein precursor import into chloroplasts. Seems to recognize chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis. Probably specialized in the import of nuclear encoded non-photosynthetic preproteins from the cytoplasm to the chloroplast.
Subcellular Localization:
Plastid, chloroplast outer membrane; Single-pass membrane protein.
Sequence:
TQGNTEEKTRILCEKLQDIRVKFVRLVHRLGQSADNGIAAQVLYRFALAEQLKGGKMRNSTSGYDKACAVAMEEEASSRDEELDFCCTVLLLGKSGVGKSATVNSIFGKPMASTSAFSSGTNKVEVIDGTMKGIRMRVIDTPGLSASMADRRYNERVVASIKRCIRRNPPDIVLYVDRLDSQSKDAALMRYIGDRFGPAIWFNAIIVLTHGASSPPDGPDGFPLRYDSYVGQRTRMFQQTVRSAVGDTRLLNPVTLIENHPACRTNRAGERVLPNGMVWRPELLLLCFSARILAEANTYLKLPESMPLTRLCERRSGSPMPVLLASMLQARSEVQQPDEEEYGEVDPDEDEDGEAEFDQLPPFRRLLQDELDALDEDNRQSYFEELALREKLFKRKLWKTQCRRWREMKNRGVEDGEDEQQQHRDMAPGISPDFALPTSFSSDDPSHRYRYVDDASWNVRPVLDSRWDHENGFNSANLDRSFHLAKNIPVSVSGQIVMDKKEYHVTFDGSAAIKHGPNRVSTGGLDIQTVGRDVCYSLWGGTTFKNHECNKTLAGMGVTMVGENAVVGVRLEDKVVIGKRAKILMSGATSLTRGDKAYGAIMEATVVGPDYPVDRTNCTLGLSVMNWTAKDIAYGINLHSQIHLGGTAMVVRGNANNRGTGQISIKVNSTDRIQLALLGLLPVIRSL