lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator.
Subcellular Localization:
Nucleus.
Sequence:
MAPNAISMDILTPKEKNRLRKPVVEKMRRDRINSSIEQLKLLLEKEFQRHQPNSKLEKADILEMTVSYLKHSKAFASCPKTLQQDYSEGYSWCLKEAVQFLTLHSANTDTQMKLLYHFQRPQASLTTLQDLKPPSSSPLPPAALTKPAPRQSPSGSNLWRPW
The following text describes a protein:
Function:
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MVRVRAVVMARDDSSGGWLPVGGGGLSQVSVCRVRGARPEGGARQGHYVIHGERLRDQKTTLECTLRPGLVYNKVNPIFHHWSLGDCKFGLTFQSPAEADEFQKSLLAALAALSRGSLTPSSSSSSSSPSQDTAETPCPLTSHVDSDSSSSHSRQETPPTAPIATVESAAAFPLATRPQRRRSSAQSYPPLLPFTGIPEPSESLAGAGSQGWGSRGYEDYRRSGPPPPPLALSTCVVRFAKTGALRGAALGPPVSLPAPLTEAAPPAPPARPPPGPGPTPAPAKASPEAEEAARCVHCRALFRRRADGRGGRCAEAPDPGRLLVRRLSCLWCAESLLYHCLSDAEGDFSDPCACEPGHPRPAARWAALAALSLAVPCLCCYAPLRACHWVAARCGCAGCGGRHEEAAR
The following text describes a protein:
Function:
Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Colocalizes with SYCE2 in the central elements.
Sequence:
MATRPQPLGMEPEGSADLLHGPEGARGQYGSTQKIEDLMDMVKKLQKVGSLEPRIEVLINRINEVQQAKKKASEELGEAQTVWDNLQKELDLLREEKVRLKDILNRKEETLRIMQLHCQEKESEAQRKHSMLQECKERISFLNSQIDKEKAKLRKLRLDFEEHLETLMSQHKDTLEFHKPEHLTKEMCVLDSSKEQLLKEEKLMKVKLEDVRQRLCALGGPEGSSSLIEGLFLRSHEAAAAMQMFKDENKKAEEFLEAAAQQHEQLQQRCHQLQQKRQRLKEELEKHGVQILAHSTQNEEDSSWRMASPKPVEVHEETAQDQERPSSRT
The following text describes a protein:
Function:
Small multifunctional phosphoprotein involved in virion morphogenesis, egress and counteracting host innate immunity. Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway. Also acts as a viroporin and forms ion conductive pores allowing viral particle release. Impairs the generation of type I interferon by down-regulating host TLR3 and TLR7 as well as their downstream signaling pathways. Down-regulates the phosphorylation of host IRF3 via the interaction with host SIRP-alpha, thereby inhibiting IFN-I expression. Interacts with host microtubules.
Miscellaneous:
MISCELLANEOUS: The viral particles present in feces and bile are non-enveloped, while those in circulating blood and culture supernatants are covered with a cellular membrane (quasi-enveloped).
Subcellular Localization:
Host endoplasmic reticulum membrane; Lipid-anchor. Host cytoplasm, host cytoskeleton. Virion. Host cell membrane; Lipid-anchor. Note=The N-terminal region seems to associate with the cytoskeleton probably via one of its hydrophobic regions (By similarity). Present on the surface of the membrane-wrapped virions (By similarity).
Domain:
The PSAP motif is necessary for the release of membrane-wrapped virions from infected cells.
Sequence:
MGSRPWALGLFCCCSSCFCLCCSRHRPVSRLAAVVGGAAAVPAVVSGVTGLILSPSQSPIFIQPTPSPRMSPLRPGLDLVFANPSDHSAPLGATRPSAPPLPHVVDLPQLGPRR
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MIGQWSKIFLIALALTSPALASFQADNAADLQLLCTAIALDGAEPTKLTTADSAETTIKHARALNMSAADETWQEIFVGGKSKNSWEAKKQKVTGEPFKSHWEADYDKWVEDKETVDSGTGQSKWLTLNPRPASAPALQAAAEKINSTLRQLLKQQAALETATTEATETYPNEAKDELIQALYGTGVTQPKFTDGKTIKHAATYANGCAKNAGLSIYGDVMCICGTQSADTSDQCADPVIAIKWSGGNDQSVISQLKAKCKTLKPAEYTAGDLEALVQRIVGRVRSAKGAGNDVIHYLGKVNLGTCTGANSQACAIYASDSGKHSAITGGLNIPWLNHLAKAAKALRKAEAAAKNTETSSKHIKILADAIQTAYSATRYNMMGKPAAAQTETQSKKTDGEDGKQHHCKQKTNQTKEECKKLGCDHDEKENKCKPKAGTEDKVAGTGDATTPNCASHTEKTKCEAENTGKSSPVCGWRKGKDGETEPEKEKCRSSSFLLNKKFALSMVSAAFVALLF
The following text describes a protein:
Function:
Orphan receptor. May play a role in brain function.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MACNSTPIGTYQHLLLNASNTLDPGATPLSAPLRISLAIMMLLMIVVGFLGNTVVCIIVYQRPAMRSAINLLLATLAFSDIMLSLCCMPFTAITLVTVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLIIVQRQDKLNPRRAKVIIAASWVLSFCISAPSFTGWTFMEVPARAPQCVLGYTEFPAERAYVVTLVVAVFFAPFGVMLCSYLCILNTVRKNAVRVHNQSDSLDLRHLSGAGLRRLRRQQQQASLDLSFKTKAFTTILILFVGFSLCWLPHSVYSLLSAFSRRFYYSASFYTTSTCVLWLSYLKSVFNPIVYCWRIKKFREACIELLPQTFQILPKVPERIQRKIQPSTVYVCNENQSTV
The following text describes a protein:
Function:
Part of the ABC transporter complex ArtPIQMJ involved in arginine transport.
Subcellular Localization:
Periplasm.
Sequence:
MKKVLIAALIAGFSLSATAAETIRFATEASYPPFESIDANNQIVGFDVDLAQALCKEIDATCTFSNQAFDSLIPSLKFRRVEAVMAGMDITPEREKQVLFTTPYYDNSALFVGQQGKYTSVDQLKGKKVGVQNGTTHQKFIMDKHPEITTVPYDSYQNAKLDLQNGRIDGVFGDTAVVTEWLKDNPKLAAVGDKVTDKDYFGTGLGIAVRQGNTELQQKLNTALEKVKKDGTYETIYNKWFQK
The following text describes a protein:
Function:
Involved in retrograde transport from early and late endosomes to late Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles.
Subcellular Localization:
Cytoplasm. Nucleus. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
Sequence:
MSSKRRQALRDFYNLPGSNSSSSTVSTTRKPSSSNTVSPVEETALDKVDPEFSDPNFDSNAYVSKFMEKATPAELLQRDKSLVASIQGLSVDHRSLVYNHYKHLLEASDAINSFCKNLNTLLPALNDAYQACPKPTRKNGNNDTYSAPQSFNGNEFSAP
The following text describes a protein:
Function:
Binds and inhibits voltage-sensitive potassium channels. Inhibits the vertebrate potassium channel Kv1.1/KCNA1 with low affinity.
Subcellular Localization:
Secreted.
Domain:
Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
Sequence:
DEEPKETCSDEMCVIYCKGEEYSTGVCDGPQKCKCSD
The following text describes a protein:
Function:
Involved in starch synthesis in endosperm amyloplasts. Plays a role in the elongation of amylopectin chains. Synthesizes preferentially amylopectin chains with a degree of polymerization (DP) of 7 to 11 by elongating chains with a DP of 4 to 7. Generates distincly chains with a DP of 8 to 12 chains from short chains with a DP of 6 to 7.
Miscellaneous:
MISCELLANEOUS: Three forms of soluble starch synthase were purified: RSS1, RSS2 and RSS3.
Subcellular Localization:
Plastid, chloroplast. Plastid, amyloplast. Note=Amyloplast or chloroplast, soluble.
Sequence:
MATAAGMGIGAACLVAPQVRPGRRLRLQRVRRRCVAELSRDGGSAQRPLAPAPLVKQPVLPTFLVPTSTPPAPTQSPAPAPTPPPLPDSGVGEIEPDLEGLTEDSIDKTIFVASEQESEIMDVKEQAQAKVTRSVVFVTGEASPYAKSGGLGDVCGSLPIALALRGHRVMVVMPRYMNGALNKNFANAFYTEKHIKIPCFGGEHEVTFFHEYRDSVDWVFVDHPSYHRPGNLYGDNFGAFGDNQFRYTLLCYAACEAPLILELGGYIYGQKCMFVVNDWHASLVPVLLAAKYRPYGVYRDARSVLVIHNLAHQGVEPASTYPDLGLPPEWYGALEWVFPEWARRHALDKGEAVNFLKGAVVTADRIVTVSQGYSWEVTTAEGGQGLNELLSSRKSVLNGIVNGIDINDWNPSTDKFLPYHYSVDDLSGKAKCKAELQKELGLPIRPDVPLIGFIGRLDYQKGIDLIKLAIPDLMRDNIQFVMLGSGDPGFEGWMRSTESGYRDKFRGWVGFSVPVSHRITAGCDILLMPSRFEPCGLNQLYAMQYGTVPVVHGTGGLRDTVENFNPFAEKGEQGTGWAFSPLTIEKMLWALRMAISTYREHKSSWEGLMKRGMSSDFTWDHAASQYEQIFEWAFMDQPYVM
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that monoubiquitinates H2B to form H2BK143ub1. H2BK143ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and maybe H3K79me. It thereby plays a central role in histone code and gene regulation. Forms a ubiquitin ligase complex in cooperation with the E2 enzyme UBC2/RAD6. Required for the regulation of flowering time and defense against necrotrophic fungal pathogens. Involved in the control of seed dormancy and germination.
Miscellaneous:
MISCELLANEOUS: HUB1 and HUB2 are involved in the same processes, but are weakly or not redundant.
Subcellular Localization:
Nucleus.
Domain:
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
Sequence:
MASTGEPDRKRRHFSSISPSEAAAAVKKQPFFWPSSEDKLDTAVLQFQNLKLSQKLEAQQVECSILEDKLSQIKEKQLPYNSSLKTVHKSWEKLTASVESCSVRVSDSSSGAHRFVNKEDGSSPAVKNDFINRLLETGATESSSSNICSNQMEENGVNTSSQMTQTLYNLVAATEDLRCLKDELYPTVLRTNLGKDLCGQLALSELESEIKSFRGDLDDVLVKFKSLSRELQSHRDADAKVRVDLKRIRGELEDEVVELQQCNGDLSALRAERDATAGAFFPVLSLGNKLATSDRERDKQRDLQDMETVLKELTVLASGRLQQLKNLHEERTKMLGKMSNLQNKSKSVRCISSSQACLSLKDQLEKSKEAVFQYMALLEKLQVEKDSIVWKEREINIKNELGDVSRKTSAVTDSRMASLDSEIQKQLDEKMRIKTRLGNISRERGRKEIFADMKALISSFPEEMSSMRSQLNNYKETAGGIHSLRADVQSLSGVLCRKTKEYEALQLRSADYASQLGDLNATVCDLKNSHEELKLFLDMYKRESTDARDIAEAKEQEYRAWAHVQSLKSSLDEQNLELRVKAANEAEAVSQQMLAAAEAEIADLRQKMDDCKRDVAKHSDILKSKHEEHGTYLSEIQTIGSAYEDIVPQNQQLLLQVTERDDYNIKLFLEGITSRQMQDTLLIDKYIMDKDIQQGSAYASFLSKKSSRIEDQLRFCTDQFQKLAEDKYQKSVSLENLQKKRADIGNGLEQARSRLEESHSKVEQSRLDYGALELELEIERFNRRRIEEEMEIAKKKVSRLRSLIEGSSAIQKLRQELSEFKEILKCKACNDRPKEVVITKCYHLFCNPCVQKLTGTRQKKCPTCSASFGPNDIKPIYI
The following text describes a protein:
Function:
Probable transcription factor involved in plant development.
Subcellular Localization:
Nucleus.
Sequence:
MAYMCTDSGNLMAIAQQVIKQKQQQEQQQQQHHQDHQIFGINPLSLNPWPNTSLGFGLSGSAFPDPFQVTGGGDSNDPGFPFPNLDHHHATTTGGGFRLSDFGGGTGGGEFESDEWMETLISGGDSVADGPDCDTWHDNPDYVIYGPDPFDTYPSRLSVQPSDLNRVIDTSSPLPPPTLWPPSSPLSIPPLTHESPTKEDPETNDSEDDDFDLEPPLLKAIYDCARISDSDPNEASKTLLQIRESVSELGDPTERVAFYFTEALSNRLSPNSPATSSSSSSTEDLILSYKTLNDACPYSKFAHLTANQAILEATEKSNKIHIVDFGIVQGIQWPALLQALATRTSGKPTQIRVSGIPAPSLGESPEPSLIATGNRLRDFAKVLDLNFDFIPILTPIHLLNGSSFRVDPDEVLAVNFMLQLYKLLDETPTIVDTALRLAKSLNPRVVTLGEYEVSLNRVGFANRVKNALQFYSAVFESLEPNLGRDSEERVRVERELFGRRISGLIGPEKTGIHRERMEEKEQWRVLMENAGFESVKLSNYAVSQAKILLWNYNYSNLYSIVESKPGFISLAWNDLPLLTLSSWR
The following text describes a protein:
Function:
Required for plastidial pyruvate kinase activity. Involved in seed oil accumulation, embryo development and seed storage compounds mobilization upon germination.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MSQSIQFSTPSHTPHLLHLPHSQFNRPLSSISFRRFPLTTIKYTSIRASSSSSPSPDLDSSSSSSSSQVLLSPNGTGAVKSDERSVVATAVTTDTSGIEVDTVTEAELKENGFRSTRRTKLICTIGPATCGFEQLEALAVGGMNVARLNMCHGTRDWHRGVIRSVRRLNEEKGFAVAIMMDTEGSEIHMGDLGGEASAKAEDGEVWTFTVRAFDSSRPERTISVSYDGFAEDVRVGDELLVDGGMVRFEVIEKIGPDVKCLCTDPGLLLPRANLTFWRDGSLVRERNAMLPTISSKDWLDIDFGIAEGVDFIAVSFVKSAEVINHLKSYLAARSRGGEIGVIAKIESIDSLTNLEEIILASDGAMVARGDLGAQIPLEQVPAAQQRIVQVCRALNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRSDALMLSGESAMGQFPDKALTVLRTVSLRIERWWREEKRHESVPLQAIGSSFSDKISEEICNSAAKMANNLGVDAVFVYTTSGHMASLVSRCRPDCPIFAFTTTTSVRRRLNLQWGLIPFRLSFSDDMESNLNKTFSLLKSRGMIKSGDLVIAVSDMLQSIQVMNVP
The following text describes a protein:
Function:
Responsible for methylating the 5'-cap structure of mRNAs.
Sequence:
MPGYDPVRDAGGSDRSSSPPNYHSDHGSRPSPSSSTFAHRASAFHEDPSSPRRSVSDHSLRRRSDADPIHGRQSMNDGVADTSIVSPRSSTTTFPQHSRDYIRYGDQELAAAHRYEHSPRNSLHSETSVRPARRSASIADLIAASEMSEAEHDNHREAHRDSARYYEEQIADRSMSRSSSASGGFQGALPHSSSHPRIPQSLPYQFGRSERSPSMAHLLNDGTAGAISDRPRSSSHSSISSHVSHQPPQQYPTQMSPLGHPPAYAASLSASHVRDRSSTSNPAVAGSSSLNRGNSPTYAVGPQQPSLSTLNRGGSSPGLGPAHVPQPTERARYATQSVSASYGPPSRSASASYAHPSASSSPASHPPIHLQPSPSHRFAVPEVPFTRSPEHKRVPLPPSPSSMHSVHPRLSMSHVSASSWNGDEYDVPSQAGMPPPQVQASPRRGSLAGLAHQGQRYVQAAPGHSIPPTPGSLASHSGYPVTPGARSVPSHTPGTVHGHTGGDGYEESNYFPRMDDHALRGFDRLRERSSSLTSPTLRQYEQLRRGSVEYDSNIDHPFGQGDVRNPIRTPGSAIAEESILSNMHAPSALPPTAVSPSFGPQLYNSELGEDKNSVALNGRRISNEGAYDVEASHAHQTEERYSSSYDSREDTYHGSRRPHSVDPGRRYSVSHDANDVSPAISSPLRRGGTGSSGPTPDGTSAQQQDQKRPRRTSATSNTSNQHAKTTETSNAPQTEIVTEATQVDSNDDQETADAVAPLPRYAPTNRVSRPGQVMRPIGMEEINRKRAECRNPLRREWEQLHQSDSREALDEILRDFHTRLASQKDAIASSNGHEEPCLDAKKRPLGDSLEDAEEVADHYNKRREVGIHGREESPIIPLRKFNNWIKSVLVGLFARGRDPSLDGRMRARGGRILDLGCGKGGDLKKWEKVRPSGLVGADIAAVSIEQAIARHRDNNNGYPGDFFAFDCFSMALSQVIPRALLEPMFDNVTLQFCMHYAWESAEKARMMLDNVARYLRKGGVFIGTIPDSRELRDRMAARANPGDRSFGNRYYKVVFDQIERWPKFGNRYTFFLEDAVENVPEYVVDFDVFEDLAHEFGLRCIYRKNFSKIYYEESRHSEHGKLLEKMRVVDRHGTLSLDEEMWQAATLYLGFAFEKM
The following text describes a protein:
Function:
May be required for disulfide bond formation in some proteins.
Sequence:
MLRILFLLSLVILVASFPLINNWLSSKSGKTIIDKDTIISIVEEYIANYPQKVIDLLTRGQAQAENEEMSKNIKKYKSELEDSSYPSAGNKDSKIVFVEFFDYSCGYCKMMSEDMKQIIQDGKVRVIFRDFPILGEASLKAVQAALAVHLINPSKYIEFYHAALNHKQQFNDESILSLVKSIGIAEEDFKVSLAKNSDTIEKMIQSTKELAQNINIRGTPAIIIGDTFIGGAADISTLRSKIDEQG
The following text describes a protein:
Function:
Dephosphorylates several organic phosphate monoesters including 3'- and 5'-nucleotides, 2'-deoxy-5'-nucleotides, pNPP, phenyl phosphate, glycerol 2-phosphate, ribose 5-phosphate, O-phospho-L-amino acids and phytic acid, showing the highest activity with aryl phosphoesters (pNPP, phenyl phosphate and O-phospho-L-tyrosine), and to a lesser extent with 3'- and 5'-nucleotides. No activity toward ATP, phosphodiesters, glycerol-1-phosphate, glucose 1-phosphate, glucose 6-phosphate, NADP, GTP or 3',5'-cAMP, ADP or ATP. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds. Capable of transferring phosphate from either pNPP or UMP to adenosine or uridine. Does not exhibit nucleotide phosphomutase activity.
Subcellular Localization:
Periplasm.
Sequence:
MRKITQAISAVCLLFALNSSAVALASSPSPLNPGTNVARLAEQAPIHWVSVAQIENSLAGRPPMAVGFDIDDTVLFSSPGFWRGKKTFSPESEDYLKNPVFWEKMNNGWDEFSIPKEVARQLIDMHVRRGDAIFFVTGRSPTKTETVSKTLADNFHIPATNMNPVIFAGDKPGQNTKSQWLQDKNIRIFYGDSDNDITAARDVGARGIRILRASNSTYKPLPQAGAFGEEVIVNSEY
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of 2-phosphoglycolate.
Sequence:
MACKVLVVDLDGTLTLGRNTYELSAEALLALRRARDAGIRVVLATANGLDFALTVARYLGIRDVIAENGCLVHLDGVTYELCSGDMAEVDRLVLSTGVVKPSHQNKCRKYDLAYIPLREDAVERLRDVLGPGYVVESSGYAIHVRPAGVDKGTAVKWLCQRLGVPCFQVASVGDSDVDVGMLSVSWGFAVGNATPAAKKAAKVVVDGPSGIGFKEAVEIILSGGACAP
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MIPQRPPEEQYKDLCHFLSPHLESFNWAVNTGLQKIPEWIPEQFVKRDGDDRILHFHVKELTLTKPYDARGNKIYPYMCRLGGQTYGGSLNIILEAAINDLPPKKFSVVANNIPVMVNSDLCHLKGLTPQEKGALMEEPTEAGGYFIYSGYEKLLRLLILNRQNYVFALNRPSFHSRGPTFTNFATSFRSMAPDCSSITTNVHYQNTGNMVVLIPIQRRMFFVPLPILLRALVEVDDRTIYESICGQNPDSFYSDRVIATLRYASELDIHTRAGARDFLGAHFRTVLQCPRHFTNEECCEVLLKRNLFPHLSDEAPSKKFDLLIYMTRRLLQLVKGEILPDNMDANSAHELLTPGTLWLPALSDAITDFLKATAANVYKDEKNAIDDFDALQTILKKNASGVENRMRYLFSTGSLRGNSTLGLSQTEGLSIIAERINYCRYLAHFRSVHRGAFFTTMKTTAVRYLLPESWGFMCPVHTPDGGLCGLLTHLARFCEIVTGDSQGFKEIVQIFTNYGMVPFLGSGDMVPVIVDGRVVGSIRERLSSAAVEALKTARRKGIIPKMAEIADLPAGSFTRSIYVFLNQQRMMRPVFNVKAQEQEYAGPLEQIFMDIASNPKDESKAYREIHHTAMLSLIASLTPFSDYNQSPRNMYQCQMAKQTMGYPSHREAASTEVKTYHVHYPQRPIVRTMEQDSHALEDFLLGTNACVAVLSYTGYDMEDALLINKCSVERGFGHGCIYKTHRYTAEEIESNSYFCNTKDGVIVDPDLDADGLPFVGQRVSKGCKLLRVYNPKENKERIMSYKDGEDGFVDKVITTTSDDGKRVLSVVLKFRMVRTPTIGDKFSSRHGQKGVFSFPWPQENMPFCENGITPDVIINPHAFPSRMTIGMLIESMCGKLRASQDCAFFDATPFTHDEKNRITDEVGQMLAKEGFEYYGNEAMYSGITGEQFKADIFMGVVYYQRLRHMVGDKYQVRATGKMNNITRQPLKGRKKGGGIRLGEMERDGLLAQGVTFLLRDRFMWCSDGHVAKLCNRCGSFMFTQTKHDENGVEETYCTYCKKSGNCTSVYVPYVLRYLCAEFAAMNIRMKFSTEEHSHAHVEEEIKEE
The following text describes a protein:
Function:
Cohesin cofactor dispensable during the meiotic division but playing an important role in DNA repair by homologous recombination (HR) probably by helping SMC5/SMC6 complex. Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication (By similarity). Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MSDSDKELENQIIEAGEKLIDPPSSLDELLSFLDKLFVSLAEVEQSPPDSMQNALTPLMKGLVGGKLFKHSDVDVKVAVAACISEITRITAPDAPYDDDQMKEVFKLIVSSFEDLVDKSSRSYAKRISILETVAKVRSCVVMLDLECDALLIEMFQHFLKAIRDHHSGNVFSSMENIMTLVLEESEDIPSEMLSPILHSVKKDDEISQVSRRLAEQVLSNCASKLKTYLTEAVKSSGVPLDKYSNIVASICEGTFSALQQDQVVANEKEDSQGHIKRETEVEKAAEISTPERTDAPKDESGKSGVSNGVAQQNDSSVDTDSMKKQDDTGAKDEPQQLDNPRNTDLNNTTEEKPDVEHQIEEKENESSSVKQADLSKDSDIKEETEPAELLDSKDVLTSPPVDSSVTAATSSENEKNKSVQILPSKTSGDETANVSSPSMAEELPEQSVPKKTANQKKKESSTEEVKPSASIATEEVSEEPNTSEPQVTKKSGKKVASSSKTKPTVPPSKKSTSETKVAKQSEKKVVGSDNAQESTKPKEEKKKPGRGKAIDEESLHTSSGDNEKPAVSSGKLASKSKKEAKQTVEESPNSNTKRKRSLGQGKASGESLVGSRIKVWWPMDQAYYKGVVESYDAAKKKHLVIYDDGDQEILYLKNQKWSPLDESELSQDEEAADQTGQEEDASTVPLTKKAKTGKQSKMDNSSAKKGSGAGSSKAKATPASKSSKTSQDDKTASKSKDSKEASREEEASSEEESEEEEPPKTVGKSGSSRSKKDISSVSKSGKSKASSKKKEEPSKATTSSKSKSGPVKSVPAKSKTGKGKAKSGSASTPASKAKESASESESEETPKEPEPATKAKSGKSQGSQSKSGKKRKR
The following text describes a protein:
Function:
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction (By similarity).
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Chromosome. Note=Loaded onto the nucleosomes of condensing spermatids (By similarity). Nuclear import is mediated by IPO4. Nucleolar localization requires the protein to be phosphorylated.
Sequence:
MDTKMQSLPTTHPHPHSSSRPQSHTNNQCACSHHCRSCSQAGHPSSSSSPSPGPPTKHPKTPMHSRYSPSRPSHRGSCPKNRKTLEGKVSKRKAVRRRKRTHRAKRRSSGRRYK
The following text describes a protein:
Function:
Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in the adult visual system to innervate the lamina layer; specific targeting of R1-R6 axons (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MTARMISIYGLVLASMMASVLASSSRFQRLPQSQSVVENESVKFECESTDSYSELHYDWLHNGHRIAYDKRVHQIGSNLHIEAVRRTEDVGSYVCIATNLASGAREASPPAKLSVIYIESASVQLLGSNRNELLLKCHVEGASGDSEPLEIEWYRNSEKLSTWRNVQLDQHRLIVRQPGSDDDGLYRCTASNAAGRVMSKQGYVYQSSVKCLPRLARRKSQKVMESWDKQTFLCRGKRGGAAGLEALPAAPEDLRIVQGPIAQSIIKEGEPTALTCLYELPDELKNQRIQLRWRKDGKLLRQVELGGSAPISGHSFDSGKDALLREDARLVLHKQNGTLSFASIIASDAGQYQCQLQLEAHVPVSSSPGVLEVIEQLKFVPQPTSKNLELDAVVAKVHCKAQGTPTPQVQWVREGENNTLPDQVEVDANGTLIFRNVNSEHRGNYTCLATNTQGQINATVAINVVVTPKFSVPPVGPIETAELGTVVIHCQAIGDPKPTIQWDKDLKYLSENNTDRERFRFLENGTLEIRNVQVEDEGSYGCTIGNSAGLKREDVQLIVKTTGDGFAPEESGGDGFLVTRAVLITMTVALAYIVLVVGLMLWCRYRRQARKARLNDLSTKEAGGDQPDATGNGKGSEQEPCLSKQHNGHSKSRSKSSGDAQKSDDTACSQQSRASKKSAHIYEQLALPRSGLSELIQIGRGEFGDVFVGKLKATLVTSPSDKDADTEKQHSNSENGSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQEQHNQSGLEQLVLVKALNKVKDEQACQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFLLATAGKVNTATAGSSSPPPLTTSQVLAVAYQIARGMDAIYRARFTHRDLATRNCVISSEFIVKVSYPALCKDKYSREYHKHRNTLLPIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQATKLPHEELTNEQVVQRSQAGSLEWSVAESTPDSLREILLSCWVANPKERPSFSQLGAALSKAMQSAEK
The following text describes a protein:
Function:
Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.
Sequence:
MIKYNKNEQAVRKVPRWVPPSTSRRDEPGSRDQQDLVFRRVRGILNKLTPEKFDKLCLELLNVGIHSKVILKGIILLVFEKALEEPKYSSMYSQLCKRLDEDAPDFEPAGSNVKTFRRLLISKCQDEFENRSRAFAAYDKQNGPLTPEEQDQRGQAKAKMLGNIQFIGELGKLGMLHESILHRCIKQLLEKKSRESLGEKAEDLECLCKIISTVGGRLDHDKARTWMDQYFDRMTRFSENMELPSRIRFMLQDSLELRDNEWKPRRRQTDHGPRTIRQIHQEELKREQQSNQAMGRFTPDFFNINGGGSGAWPARGGLGDLFLQDTMSGRVGAGPGVISDELSPNPGFGSYSPRTQHRQMGQQQQQQQQGQQGQQRGSNNRSDSGDRQRDQGNQQGGYQNQAPRFQQRGGNQQRGNRNDDNQQQQRYQQRGGHDQQRGGYDHQRGSGNQQHHQGRNMNQQGQQQQHYQQYPPPQQQQRDYNQGGYNNKQQNKQYYNNENQDYGGRGGSGERDRDRDWDGDRGGRMGNRGGGMDQGRYGQQRQDRGQQDKPYGGGQQRDGGGGGGGRQRDDVRESRPPRINKLDTGEINLRPSGNMVLKPQVPRFLPPSATSNSPNSSPPRGIAPIHGLLPTNPPPNNVQQPPPLQTGYPGLPVKHSAAGSLGGGTGGAPAGERRIERKKQPTKEELLKSMEELLTTYLESKDDEAVIKSFKGLLAPKRHVPALLTYVMTHCIQQSDTERESAANLLSVLKKEGCITGNNFMDAFTSFLESSKELESEVPLIKSHTAGLAARAVTDEVVSLADIADPLENGAFYPLFLLILQRIAKAKSKDGLVALFNESKVAMLKMLPESDRNKERMMEILEGKSLSFLFPLLRMQADVTKQLQSDSNPSALYKWIKENVSVTIHKDKGFINALTASVIKFIVAETSLPEGADPAVLPDKSLQEKETALLERFAPVLQKFVHVSIDLQLGALYALQTQCYNLSFPKGMLLRFFVNLYNLEAIEEEAFIKWKEDITDEFPGKGQALFQVNQWLTWLATAEEDSDSDEEVDD
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MDYKDCYGYLAALTFVVSLCSGAPLTDNDPVAEQISDLCKEKFYVETLIQNLKQRVQSTAASIKDMEKLKATWEKAAAATSDAAKKCLFSALEHKADAELLRELPKIEEATEAVTTAQIALSEHVGMLGATITLAKTKLDSGSSNHGNAGTGSIRIALSRTTATTDLCNEPATISDIKPGVSEIQPDKLFKLKLTKPTDLHKHMFVDWLTIGGLTSCTAHTSYDQNFDAALSGCNYKTAATAEAKQATTKPTYGTTEVTLFKNNDPEQQCEVTDLPAGGAADKHKKLQHSLCRALQLGNVNGRSLRQLNGAALQSDHVVANTIRNCDPVFQKLTTATDGEGTTELKKYIKEAYGSSASEFAEKFITNAEKLQMTLRLNDKIETKDLSAVSPGEQTAAALSHIQGLHNKRELEAGKKSTSAAAVDPQKSEDCKGEKDETKCNKKDGCEFKDGECLAKVTTAAGTDGKTNTTGSNSFVIHKTPLLHVCLLL
The following text describes a protein:
Function:
Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans such as biglycan, syndecan-4 and glypican-4. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Consequently, facilitates inductive processes in the developing embryo, such as posteriorization, mesoderm induction and neuronal differentiation. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
Subcellular Localization:
Cell membrane. Secreted. Cytoplasm, cytosol. Note=Predominantly secreted. Also found associated with the plasma membrane.
Sequence:
MTMLWLAVLLTCGAPAALLPTSGVGCPARCDPSSCSPAPTNCQSGETALRCGCCSVCAAAENERCGEGPEDPLCASGLRCVRNGGVTRCQCPSNQPVCGSDGKTYSSLCRLQAESKAVQGRGVAAIIPIQRGDCQQGQKDPDSPRYKYNFIADVVEKIAPAVVHIELFRILPFFKREVPAASGSGFIVSEDGLILTNAHVVTNKHRLKVERSDGSTYDAQIIDVDEKADIALIKIKAKGKLPVLLLGRSEELRPGEFVVAIGSPFSLQNTVTTGIVSTAQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVVGINTLKVTAGISFAIPSDKIRKFMAESHNRQSTGQGTKKKKYLGIRMMSLSQGKLKELKEQVKDFPENTSGAYIVEVLPDTPAEEAGLKEGDIIISISGKTVTSSSEVSEAIKKEGTLQMVIRRGNEDIPISVTPKEIEF
The following text describes a protein:
Function:
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MAALRSSSARVFAAASRPAFRPVVAARGMANLADGATQSQQASSEQSPKLKTFQIYRWNPDTPTEKPRMQSYTLDLNKTGPMVLDALVRIKNELDPTLTFRRSCREGICGSCAMNINGTNTLACLCRIPADNSAEMKIYPLPHTYVVKDLVPDLTLFYKQYKSIKPYLQRDTPSPDGKEYRQSKADRKKLDGLYECILCACCSTSCPSYWWNSEEYLGPAILLQSYRWLADSRDERTAERKDALNNSMSLYRCHTILNCTRTCPKGLNPGLAIANIKKELAF
The following text describes a protein:
Function:
Regulates the size of the shoot meristem by modulating the CLV3-WUS feedback loop. Can repress WUS but is under negative control by CLV3.
Sequence:
MSLVVCQPQINESFYQKDDMGGLSFLQSMSDITSIAQTKEDKAYVHPMEKRSVSKLNEKSLEMCTESLGTETGSESGDELSLLAFEATTTPRAPPRQLKPQEDTNLPDKTPPMSRNNSFPPPIKFVEDSKYNRMVRWLGEDGRIVVQAIRVSSPPSCFVSERGEGRLRLILTSESSLLSHNHEEEEEEETEEGIDEETSENLEGKSGNKKFSRFSRRCKENGREPKPMLTWKQQQFWVAT