lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates. Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity. May also hydrolyze long chain retinyl esters such as retinyl palmitate. May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border.
Subcellular Localization:
Apical cell membrane; Single-pass type I membrane protein.
Sequence:
MNGFALFLSLCLLLNTQSATLAQEEVSFLDDQPIITVYRNLHKQFFNYVGPNSENPERLKQARSQGKIQLPIPPDQPFPCPTEGMRSARVPTSVHELRPGDIDVVAALGDSLTAGTGVLATGILELIIENRGLSWCIGGQGTWRQYLTLPNILKVFNPNLNGYVVADSLSIDRASRFDVAEIAGMSQDLPHQARNLIKRMKADRSVSIKKDWKLITIFMGHNDFCSRICFLPKPEKALYQHEQNLLTTLRLLRKYLPRAMVNIVATIDVTVLRTFSPRPASCVTTHAFECPCVFGTRYASFQPRLEYIIHQWNRIQQSVAEREEFNNATDFVVNFQPFPEQLTLPTLQNGDTDAGIASVDCFHFSQRGHAIAANSYWNNLIDMEGNKTELVQREFERFSCPMKGRPFLATRKNSLKKV
The following text describes a protein:
Function:
ATP-dependent protein-folding chaperone for the eIF2 complex. Binds to the gamma subunit of the eIF2 complex which allows the subunit to assemble with the alpha and beta subunits.
Miscellaneous:
MISCELLANEOUS: Present with 4850 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSQEYTTFIDIPVTRAQVEHCSYSFWSSLYPKYVPKSIVLKSLPKKFIQYLEQDGIKLPQEENSRSVYTEEIIRNEDNDYSDWEDDEDTATEFVQEVEPLIDFPELHQKLKDALNELGAVAPKLNWSAPRDATWILPNNTMKCNEVNELYLLLNASNYIMHDLQRAFKGCVDGDDIKGLKFDLVLRQWCDMNPALEFRVFVKNAHIVGATQRDLNYYDYLDELSDTFKDLIDEIVHDVVLPKFPDKSFVLDVYIPRPFNKIFIVDINPFARKTDSLLFSWNEIAAIAPPKNDVEDYELRLVTRHNTGRFASKEHSENHVPQDLVEASLNPEAIRELTQKWKELLSQQAKEESSDSENET
The following text describes a protein:
Function:
Cardioactive peptide. Corazonin is probably involved in the physiological regulation of the heart beat (By similarity).
Subcellular Localization:
[Corazonin]: Secreted; [Corazonin precursor-related peptide]: Secreted.
Sequence:
MLHTRTIALLLVGLVVLVNAQTFQYSRGWTNGKRSPLSSSSSSPSSSAAMEPLTANQLLASALSSGGLNSLKPSEKALLRRFLRNPCDLRVASLLAAAHPTKELFPLAGNSFDSAESAGAAFVLPPFLMDPDESNGGIGGSNLANGRSMEDELRFKRGTATGFSDHRQKIA
The following text describes a protein:
Function:
Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for the translocation of the multiple pectic enzymes (Probable). This subunit forms the outer membrane channel (By similarity).
Subcellular Localization:
Cell outer membrane. Note=Most of the protein is in the periplasm which it traverses to contact proteins of the cell inner membrane.
Domain:
The N0, N1, N2 and N3 domains are periplasmic, while the secretin and S domains form a channel that is partially inserted in the outer membrane. The N1, N2 and N3 domains each form a periplasmic ring. The secretin domain forms a double beta-barrel structure; the outer barrel has a diameter of about 110 Angstroms while the inner barrel forms the central gate with a small pore in the closed state (By similarity). The S domain interacts with pilotin OutS.
Sequence:
MLGKGIKKSWGWLGLTVLLLGSPCGWAAEFSASFKGTDIQEFINTVSKNLNKTVIIDPTVRGTISVRSYDMMNEGQYYQFFLSVLDVYGFSVVPMDNGVLKVIRSKDAKSSSIPLANNEQPGIGDELVTRVVPLNNVAARDLAPLLRQLNDNAGAGTVVHYEPSNVLLMTGRAAVIKRLVDIVNTVDKTGDREMVTVPLTYASAEDVAKLVNDLNKSDEKNALPSTMLANVVADGRTNSVVVSGEENARQRAVEMIRQLDRKQVVQGGTKVIYLKYAKALDLIEVLAGNGTSGNRNSSSSNASRPSSPRSGSSSNSNSSSGSSGSSSGSSSSSSSSSSMGFGSAFGSTSSSGGRTITIQGKEVTVRAHDQTNSLIITAPPDIMRDLEQVINQLDIRRPQVLVEAIIAEIQDADGLNLGIQWANKRAGMTQFTNTGIPISTAVIGTDQFRSNGTLTTAYASALSSFNGVTAGFYRGNWSMLLTALSSDSKNDVLATPSIVTLDNMEATFNVGQEVPVLTGSQTTSADNIFNTVERKTVGIKLRVKPQINEGDSVLLQIEQEVSSVADSNSSTNSSLGVTFNTRTVNNAVMVTNGETVVVGGLLDKTSVESNDKVPLLGDIPWLGSLFRSKSQEVRKRNLMLFLRPTIIRDPGQFQEASINKYRSFNNEQQQQRGEGNGVLDNNTLRLSGGNTYTFRQVQSSISDFYKPEGR
The following text describes a protein:
Function:
Polyglycylase which modifies both tubulin and non-tubulin proteins, generating polyglycine side chains of variable lengths on the gamma-carboxyl groups of specific glutamate residues of target proteins. Involved in the elongation step rather than the initiation step of the polyglycylation reaction. Polyglycylates alpha-tubulin and beta-tubulin. Polyglycylates non-tubulin proteins such as nucleosome assembly protein NAP1.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme.
Domain:
Gln-246 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate-chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation.
Sequence:
MGSSQEEGLPCQPSQPDHDTGGHGGPDLEGAGRVSTTPGPPGLLTSHPPADSDDTDATGPPAALLEGLLLGDGKPSPHSTRPGPFFYIGGNNGAAIISSYCKSKGWRRIQDSRREDYVLKWCEVKSRDSYGSFREGEQLLYQLPNNKLLTTKIGLLSTLRGRAWAMSKASKAPGGTQARLGKDATAPTLEDLPWTSPGHLRPQRVLRMEEFFPETYRLDLKHEREAFFTLFDETQIWICKPTASNQGKGIFLLRNQEEVAALQAKTRRAEDDPIHHKSPFRGPQARVVQRYIQNPLLLDGRKFDVRSYLLIACTTPYMIFFSHGYARLTLSLYDPHSSDLSGHLTNQFMQKKSPLYVLLKEDTVWSMERLNRYINTTFWKARGLPKDWVFTTLTKRMQQIMAHCFLAAKSKLECKLGYFDLIGCDFLIDDNFKVWLLEMNSNPALHTNCEVLKEVIPGVVIETLDLALETFQKSLRGQKMLPLLSQRRFVLLHNGEADVWPRLGGSCSLRRRLPPPTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGTGDRHPEQEPSPGTAKEEREEPENARPWGGHPRPTPHAPATLPAFRDL
The following text describes a protein:
Function:
Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MNRIYLYLLIVLILAGCSSPGGRYDMSDDQAPDTPLSVEHIEDAHPQYEPYSFGGNKDYNLRGKSYRIIKNPKGFTESGKASWYGKKFHGHLTSNGEIYDMYSMTAAHKTLPIPSYVKVTNTDNGKSTVVRVNDRGPFHDGRIIDLSYAAAYKIGVVQAGTANVRIEVITVDKPTKPRPKSKNNALEYVIQVVSSQHIERVRTLAQNLGQNLSAPSFVESTNNTHRLFLGPFTDDDLTQTLLEQVKSAGYDSAFIKTINKRAK
The following text describes a protein:
Function:
Has porin activity, forming small water-filled channels. Also has a structural role in determining cell shape and ability to grow in low-osmolarity medium.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Domain:
The N-terminal beta-barrel domain (residues 25-184) when reconstituted into lipid vesicles is blocked at both ends.
Sequence:
MKLKNTLGVVIGSLVAASAMNAFAQGQNSVEIEAFGKRYFTDSVRNMKNADLYGGSIGYFLTDDVELALSYGEYHDVRGTYETGNKKVHGNLTSLDAIYHFGTPGVGLRPYVSAGLAHQNITNINSDSQGRQQMTMANIGAGLKYYFTENFFAKASLDGQYGLEKRDNGHQGEWMAGLGVGFNFGGSKAAPAPEPVADVCSDSDNDGVCDNVDKCPDTPANVTVDANGCPAVAEVVRVQLDVKFDFDKSKVKENSYADIKNLADFMKQYPSTSTTVEGHTDSVGTDAYNQKLSERRANAVRDVLVNEYGVEGGRVNAVGYGESRPVADNATAEGRAINRRVEAEVEAEAK
The following text describes a protein:
Function:
Involved in the maturation of specific proteins in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MISLRYTRNLFLRSFCIVYLFAFISFYIQIPGLYGDNGILPAKSLLENSKHKTLSAKVHYQPTLLWLAPYLGLDVNYALDVLALLGSFLAFTGFISQKFCTIPLFAGLWSLYFSLYQVGQVFVSNNYDEFLLEAGFLVLLVAPLLPGRRKGSKVLPSDSISFWLVRWLLFRFLLTCGLLKFISGCPKWWTLSAFNYYFETLPLPTPLSWYFHQIPSWYLKLFGVIANVCEIGIPFLFFVPIRAVRITSFMIQIFLQISIVLTGNYNFTNLLMVTLLLSLLDDQFFYGRRKPFTKWTFIEKVINILTYGALLLAVVKLYSLKLDGTIIESNIAFTKDQFEYVLKQGLTITIYLGLISLAVTILRALSISLFDVQGSKVFTIITTILYSGIAVLLFFASTVPLASLHTASNSTVHPSVRTVYNRLHKLHAVNQYGLFPKMMGVDGRPEVILEGSDNVEGPWLEYNFLYKPGNVNHSLPFVAPYSPRLDWQMFWAAYNTYDKQPWILSLTHRLLTGKAEVLALLDRHHSPFNQKPPKYIRGILYKYKYSSWSQRSQPSWWVRQKVGEYFPAYTKESPALVDYLKARNLLPTSSKQTVNPIWKQILDGVRYITGHLEATLLLWSVFTAGCAIITTSAKK
The following text describes a protein:
Function:
Essential protein required for cell fate determination during embryogenesis. Involved in sister chromatid cohesion. Forms a complex with SCC2, which is required for the association of the cohesin complex with chromosomes.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Associates with chromatin, especially during telophase, prophase and interphase. Mostly localized in the nucleus during interphase and preprophase stages, but not in the nucleolus. During prometaphase, metaphase, anaphase and telophase, mostly cytoplasmic.
Sequence:
MEGAAVAEGLWGLADHHQKLGEIGKTIKCLEAICQSQISFLPLVEVKSRLRLAALLLRYSHNVNHAKSHLERSLLLLKSIPSSYDLKFQNYSLLSHCYHLLASFPPQRNLLVKALELASSVPQDISAYLWSCNFNSQLANTFIIQADFPSSLSALESGFLSASHICFPELQMFFTASMLHVHIMQWTDDYSVEKAVQRCDEIWQTISSDKTDRCPGLFFYNEMLHVFYRLRLCDYKNAQHHVDRLDQAMNAHSHKMQEIQQLLDELSSLNLSLSRYDLPSRERSALSARQSQLQDRVNALSPSSSTVNSLEPAYFGNIDRGWTEKLLLSPSPIDGEWLPKSAIDALVHLMVVISGRPKGLFKECSKRIESGLQIIQDELIKLGITDEVREADLRHTAIWMSRVFLMLQMQFLENRVALELTRSDYVEAEEALVDMKNWFTRFPTILQASECMIEMLRGQYSHSVGCYSEAAFHCIEATKLTESISMQASCQAFAAVSYLTIGDAESSSKALDLIGPLNGMTNSLSGVREEASILFAYGLLLMKQRDLQEARNRLAKGLQIAHNHMGNLQLVAQYLTLLGNLALSLHDTVQAREILRSSLTLAKKLYDIPTQLWVLSIFTALYQQLGEKGNEMENEEFRKKKWDELQSRLAEARGSIHHIELVAKARIELYQIDNNPQEQSLVASAQSMQGNLDIPESVGIEGPSPAPSSSRLVGLDTGKRWGKRRM
The following text describes a protein:
Function:
Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high-temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the decarboxylation of N1-(3-aminopropyl)agmatine to yield spermidine and urea. It can also use agmatine to yield putrescine.
Miscellaneous:
MISCELLANEOUS: In T.kodakarensis, two kinds of synthetic pathways from agmatine to spermidine are predicted. One is the pathway via putrescine (pathway I), and the other is that via N1-aminopropylagmatine (pathway II).
Subcellular Localization:
Cytoplasm.
Sequence:
MEFLYTYETLKLEFPLVEPEKARFILLGVPFDGTTSYKAGARFGPTLIRQATLNLESYILDYDLDIAELPIADIGDIAVVAGDPRKTADRVRETLEELKKANPKAIPILLGGEHSQTLGAVEALKPASYVVFDAHLDLRNSYEDNPYNHACVARRISELGVKEAIFGIRSGTKEEVDFARERDIPWVHARDYSFDAFVDLVEALPEPVYLSIDIDVFDLSMVPSTGTPEAGGLRFWEVVEAIEWLVEKKEIAGFDIMEVAGEKLGDPTALTAAKLLFYSIGAMAKFGR
The following text describes a protein:
Function:
Required for male fertility through its role in axonemal doublet stabilization which is essential for sperm motility and fertilization.
Sequence:
MNNSLDYLAYPVIVSNHRQSTTFRKKLDFGHYILHKNRVQIVKPAVDTKPPMAHTHYILKLSKIQGEQKRIDKIEYENRQLCQKIANAYRGPAKVDCWNEYLSKSLNRESRNRELVRITMENQGILRRLSDRKPNYDRRSSEMDWQNSRRYIRNTTRYLLFQED
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MDKDRLAAGPCSWLDMHHFIGDLMAASATVTGHPMAERRTEETLSSWPKVPHPPQSIPSRQNPVKNAVRFGVQSEEREPRHNESHAHRRTCTCPGCPLSSTPSSSSFQTLKPKASSASQIQPPSSTQSTPLQQAKEPSTAPVSLGLCLGLGLSLDEENTGSSSTSRPPQQEDKGTSTHSPIPQSNPESPGVSPAQAFPCVCCHRGFQTCSQLLSQQKDPESQIAHHYYHHHHHHCPLSSCTSCTHPSFPCLSCQRTFPTCAQLLRHEQGHAQQDGLQQLSCMHCNASFPRPSQLLQHQRTQHATKAGGFLCAECGRAFNSHSNLRIHLNVHTGARPYICTNCGKSFSQSGALKIHRRIHTGERPYTCSYCGRGFPHLAGVRAHQRIHTGEKPYICGQCGKCFTQSGALKIHTRIHTGERPFVCGLCGKSFSNRSGIRFHHRTVHGIVMEPNSVGRPSLAASASSQVSDIQRVQVSAVNQIHFRQIEERNLPSKELVQPSKEQLSGNADKLALPYACEDCGQRFPDAPSRNRHQTLQHYSLEEQEKEDTGSSKTND
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MYWVVVLLTVLHSCHRALGKEDIVNQKEFEALCRMINWAEERLEHIKVTKRVTQEALKIGVRYLEVAGEEECRHIAKAQEDSCTKKMEDRKRNCGLYKNFWEEAQKAVKERAFSGEKLERKIDALGEHTVDEIKKKGMYGADIYHDVEAKRPSGNMRKMEEHLIKALYGMEYFSEDIKGGDSDRSRVCGQNLRNNKATGGWSLAVDLLCLCATHNSWKGRKKVCCADCSTGENRDEWNPESNEAPRWDFLKQKCAGRHRNRHDMIEKLSEAEENLMKTVTKIGTIPYTHTYVLGTAVNSRIKPCGADINKQQEICVHYGSDNGTKLPWLKALQKVEKEMKLTLKDKQDKSAKLKRMEELNQEIESLIRGDTGRGGQRGRQKRSVNPENSVPETPADPSDPTQSVPHTNEKKRSVRKPISTGNGATKSYNSEEDDSYEYECEGENSACSDSPAKPTVKNSKSAINCPLGLILLLV
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLFRFRAQQAADLGIIDIGRTRRPKAITSVDSIPSCEKWRGQVLKEISRKVSRIQEPSLSDYQIRDLNDEINKLMREKWAWEMQIRNLGGPNYMRGSGRVYDDEGREIPGGGKGYRYFGRARELPGVKEMFEAAARRGRRPPEEEEEEEGKGRGGDIATKKVDANYFGYGLDEEDGSLLAYERQKEKEAVEYLRGQKDSDAEDGWEPLPGDAGDGVEWRLPTLEEVQEELVDRRRRRLLDKIS
The following text describes a protein:
Function:
May act as a transcriptional regulator. May play a role in neurogenesis and neuroendocrine cell differentiation during embryonic development.
Subcellular Localization:
Nucleus.
Sequence:
MPRGFLVKRNRRGAVFYRSHSQSTSERPGTTEEGALNEATRAEKPGLRGVESAESRKDSAGVSEAWSPHIESTLEAEAERRAQLPDTEEEVSVVDVLGLDGDLSCFYAPPPPNGVTLIESCSSVKPVSARLLEHQKHISFTGSCLTSSPVPEVPDLAFLSNPTPTAIPASIEKLLGDSSRPFTQPHGITDKYEISHMHVFPPLTLVTPEQQHAARKRSFLQEPHSKHHSKQGNPSKKPKINRKLNFEDEVTTSPVLGLRIKKESPEVRRQRETTSTPTAQPLGEFICQLCKEEYPDPFSLAQHKCSRIVRVEYRCPECDKVFSCPANLASHRRWHKPRPVISQGVETNRMRAADSPPSSLLLRNGDPHERADVLPPPSLTHPHLSNPPFIQALTEEEVYECRYCGKKFRRQAYLKKHLVTHEMSRPTSSYNQKVNGSQSQQVFLCHLCGARFPSVEIRDKHRLWHHQQIFTCKYCPSTFFSSPGLTRHINKTHPTENRQVMRLQMTVRP
The following text describes a protein:
Function:
Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
Subcellular Localization:
Endomembrane system.
Sequence:
MEEPLRKTLRDESPYVRKTAALCVAKLFDLAPAMAIENGFIEQLQELVGDPNPMVVANSVTALVEIQETSPETRALAITPTTLKKMLLALNECTEWGRVTLLTTLADYKASDVKEAEHICERVVPQFQHVNPSVVLAAVKVVFLHMRYISPELTKSYTKKMAPPLDILSKEMRVFFCKYNDPPYLKMQKLEIMVRIANDKNVDQLLAELKEYAMEVDMDFVRRAVKAIGQVAIKIESASEKCVNTLLDLINTKVNYVVQEAVVVIKDIFRKYPGYEGIIPTLCQCIDELDEPNARASLIWIVGEYAEKINNAGEILGNFVDTFAEEFTQTQLQILTAVVKLFLKKPDQAQGLVTKVLQAATAENDNPDIRDRAYVYWRLLSSDPEVAKVRSTASVYHKPPEAFLGQGRFGAEAMQRAAIEEQEEEARENPIAAAAAAAAVTGKAPPTTNMENLLDIDFDGSAPASMQKAPSSGESGLEGLAGTPQRVASPAGNAPAQPQSNMDDLLGLFGDGGGAAPPASAQMSNDDIMGGFAGMSIQNNQPPPPAQQMGGEPSKKSNQDLLDLF
The following text describes a protein:
Function:
May be involved in cell wall biosynthesis.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MKDINRVLDLGSSKLTVLLSLSGFMILVLLVIEDVDILHWRALWVWKAMPSEQTRISAGSIDPSCVSRSSQHLYRANKVADISPTLLESWKRYGELHRKCAPSNWTEVLEESSHVNSSCKFMIYVETHEGLGNRILSLLSALLYSMITDRVLMIDSRKEVGKILCEPFQGSSWLLPADFPYGEPWFSSLWFPEIVKHAPDLGQAIDKNFSVPIVHLHLAHVQRETDKLFFCNEFQEPLSHVRTLAWSSNQYFVSSFFKVPWMWRKLVTLFPGSRLDIFAQLSSLAIAPANSIWSLVSRFYNSYLSCSKSRVGVQIRTHSRPDLASFDPLVNQIVSRCLTSHHLLPNLSSSSSPSLIEFEKQQQQQHQVDVSVFVASLQGKYYETLRDEFLQNGTASEELVSFHSLSSEGAEWHNLHQASLALAEMWLLSFAHHLATSEFSTFGYISRGLARTRPWMLKIRGTELHPEGDVCYLSQSSEPCTHFPQQPDCSSARNISTEHREWIKRHLGGCQDQRGGLQLLNL
The following text describes a protein:
Function:
Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3'. Mediates the transcriptional response to hypertonicity. Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17. Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA.
Subcellular Localization:
Chromosome. Cytoplasm. Nucleus.
Sequence:
MLFRGASPRPPAAALALPGCGAPPSAPAQCPAGGGAQIPVSGGGGGGDRQFSLRRSTKRTRWLSPPPCPRPEPPSWLAGNQPPWSFPLRLAAVSSVLGPVEVPALEEEAAAAALASPPPDRCPRSRRGGAAATAAPPPSRCPRAGLGRAAMPSDFISLLSADLDLESPKSLYSRDSLKLHPSQNFHRAGLLEESVYDLLPKELQLPPSRETSVASMSQTSGGEAGSPPPAVVAADASSAPSSSSMGGACSSFTTSSSPTIYSTSVTDSKAMQVESCSSALGVSNRGVSEKQLTSNTVQQHPSTPKRHTVLYISPPPEDLLDNSRMSCQDEGCGLESEQSCSMWMEDSPSNFSNMSTSSYNDNTEVPRKSRKRNPKQRPGVKRRDCEESNMDIFDADSAKAPHYVLSQLTTDNKGNSKAGNGTLENQKGSGVKKSPMLCGQYPVKSEGKELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGHNEPVVLQVFVGNDSGRVKPHGFYQACRVTGRNTTPCKEVDIEGTTVIEVGLDPSNNMTLAVDCVGILKLRNADVEARIGIAGSKKKSTRARLVFRVNITRKDGSTLTLQTPSSPILCTQPAGVPEILKKSLHSCSVKGEEEVFLIGKNFLKGTKVIFQENVSDENSWKSEAEIDMELFHQNHLIVKVPPYHDQHITLPVSVGIYVVTNAGRSHDVQPFTYTPDPAAAGALNVNVKKEISSPSRPCSFEEAMKAMKTTGCNLDKVNILPNALITPLISSSMIKSEDVTPMEVTAEKRSSPIFKTTKTVGSTQQTLENISNIAGNGSFSSSSSSHLPSENEKQQQIQPKTYNPETLTTIQTQDISQPGTFPAVSASNQLPNSDALLQQATQFQTRETPTREVLQSDGTVVNLSHLTESSQQQQQSPLQEQAQTLQQQISSNIFPSPNSVSQLQNTIQHLQAGSFTGSTASGSSGNVDLVQQVLEAQQQLSSVLFSAPDGNENVQEQLSADIFQQVSQIQNSVSPGIFSSTEPAVHTRPDNLIAGRAESVHPPTENTLSSQQQQQQQQQVMESSAAMVMEMQQSICQAAAQIQSELFPSPASANGNLQQSPVYQQTSHMMSALSTNEDMQMQCELFSSPPAVSGNETTTTTTQQVATPGTTMFQTSSSGDGEETGAQAKQIQNSVFQTMVQMQHSGDSQPQVNLFSSTKSMMSVQNNGTQQQGNGLFQQGNEMMSLQSGNFLQQSSHSQAPLFHPQNPIADAQNLSQETQGSIFHSPSPIVHSQTSTTSSEQLQPPMFHSQSSMAVLQGSSVPQDQQSANLFLSQTPMNNLQSNTVAQEEQISFFAAQNSISPLQSTSNTEQQAAFQQQAPISHIQTPMLSQEQAQPSQQGMFQPQVSLGSLPPNPMPQNQQGPIFQSQHSIVAIQSNSPSQEQQQQQQQQQQQQQQQQQQSILFSNQNTMATMTSQKQPPPNMMFNPSQNPMANQEQQNQSIFHQQNNMAPMNQEQQPMQFQNQPTVSSLQNPGPTQSESPQTSLFHSSPQIQLVQGSPSSQEQQVTLFLSPASMSALQTSMNQQDMQQSPLYSPQNNMPGIQGATSSPQPQAALFHNTTGGTMNQLQNSPGSSQQTSGMFLFGIQNNCSQLLTSGPATLPDQLMAISQPGQPQNEGQPPVTTLLSQQMPENSSLASSINANQNIEKIDLLVSLQNQGNSLTGTF
The following text describes a protein:
Function:
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
Subcellular Localization:
Nucleus.
Sequence:
MSFVYGAQNAWDMLSDEQSQKHITTGSGDLNHILGGGIHCKEVTEIGGVPGVGKTQLGIQLAINVQIPVEYGGLGGKAVYIDTEGSFMVERVYQIAEGCISDILEHFPHSHDKSSSGQKQLQPEHFLADIYYFRICSYTEQIAAINYLEKFLGEHKDVRIVIIDSVTFHFRQDFDDLALRTRVLSGLSLKLMKIAKAYNLAVVLLNQVTTKFTEGSFQLALALGDSWSHSCTNRLILYWNGNDRYAHLDKSPSLPVASAPYAVTGKGVRDAVSPNHKRVRVA
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MAPVQIGSDGQLVPAGGPTSTPQPPPGAPATQGVRLSLLIEFLLQRTYHEITLLAELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQAYLFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKAEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQVNYIHELVQSRLFGDDKPLQDMYTCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYIPAKCLTLSVWNQQVLGRKTGTASVHKVTIKIDESDGSKPLQISHEPPLPACDSKLMERAMKIDHLSVEKLLIDSVHARSHQKLQELKAILKSSNPNDNSFIETALPTLVIPILEPCGRSECLHIFVDLHSGMFQPMLYGVDQSMLDDIEKSINDDMKRIVTWLLQLKFWLGEQRCRQSVKHLPTLCTDTLHLSNLTTHPVGNLSKHRLFIKLTRLPQYYIVVEMFDVPSNLTELQYKYYFLSVSQMESEDGLPSAQLFRHFKPNLEELVQDISSCRMVRPGTKRKLSGEQSAVEPKKPKRSGEMCAFNKELAHLVAMCDTNMPLIGLRSELSNMEIPHQGVQVEGDGCSHAIRILKVPPCMAVGEETRKALERSLLDCTFRLQGRNNRTWVAELIFSSCPLNSTSIKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWNSISKLYECVLEFSRSLTEMPSYLSLFSEIRLYNYRKLVLCYGSTKGSSVTIQWNSVTHRYHLALGTVGPNSGCSNCHNIILHQLQEMFNKTPNVVQLLQVLSDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPISMEDTFMPHTQTQPPGRGVYPPLTSPPNPYHVPPSPSMITTQSPGTLDPSSPYTLVSASPRVGPWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDPSHSPRAGTSSQAMPPPRKLPQRSWAASIPTILTHSKLHVLLLPSPMPCPVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQLEPNLTIVNSNEPGVIMFKTEVLKCRVALNPKSYQTLQLKVTPENTGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPDQAAQLNWNVQFCLTIPPSAPPIAPPGTIAVVLKTKMLFFLQLTQRLPVPQEPISIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSSILRRFNEHHPPRPGECTIFAAVHELMANLTLNSGGRP
The following text describes a protein:
Function:
Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MNCSESQRLRTLLSRLLLELHHRGNASGLGAGPRPSMGMGVVPDPFVGREVTSAKGDDAYLYILLIMIFYACLAGGLILAYTRSRKLVEAKDEPSQACAEHEWAPGGALTADAEAAAGSQAEGRRQLASEGLPALAQGAERV
The following text describes a protein:
Function:
Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase mtq2, required for the methylation of eRF1 on 'Gln-182'. Together with methyltransferase trm11, required for the formation of 2-methylguanosine at position 10 (m2G10) in tRNA. Together with methyltransferase bud23, required for the formation of a 7-methylguanine in 18S rRNA. Involved in biogenesis of both 40S and 60S ribosomal subunits (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKVMTLNFLTCAVKNCKSSNDSFPLHPKEAELAKDDIEINPQLLINVLPRIDWAALRTTSTELGFPTLPEQPPSPEDLQSDEALLKELHELLMETQMMEGKLVCGHCGHEYAVKNGVANFLLPSHLV
The following text describes a protein:
Function:
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Contributes to CPC function by facilitating loading of the CPC onto chromosomes (By similarity).
Subcellular Localization:
Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transfers to the spindle midzone and midbody from anaphase through cytokinesis.
Sequence:
MPPKRNRKRLGTRGEGSGDSGVGMFERNDAVQEQKKEKIRLFMQDFVQQGKDRLAELKKDLESLSTTADKALEVELLKMPLAIRHMKVQDYLSLMGGDKTAVAAAAVKLDCSVDELSEPKLVRKSSKKVKVTTNVEYQDDIRTKVMTTTGKTRTVQKVPKSKSMLSLTGKNSKKTTALTRSVSATPIDKASKKLLVTNSSSKPAQRSSRTAMTPLSRSARSDAVFSFGDGTFLDEGVPFVKIPLADGQTVFSAGDDLDSLNVELLRGDTVQHIHNLVGQLTNLCAKASIQQHGNTL
The following text describes a protein:
Function:
Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
Subcellular Localization:
Cytoplasm.
Sequence:
MKDKLVKAIAKDGQVRIIGAITTELVNEGVRLHNCAPTAAAALGRMLTAGALMGTTLKSEKDTLTLQIHGGGIAKGVVITSYADGHVKGYIGNPTADIEPNSKGKLDVSGIIGKNGNLLVIRDMGLKEPYIGQVPIYTGEIGEDLAYYYTVSEQTPSAVGLGVLVDKDLSIKSAGGFIIQMMPGADEMLADLISYRLEEIPSITEMISKGMTIEEILEYIFEDMDLKILESIVPEYRCDCSREKVERALASIGQKDLKEIYDEGKEEELKCHFCNKAYVFSHDEVGDILENYYSEK
The following text describes a protein:
Function:
Involved in protein trafficking.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MFYKYNAWDPKLIIGQILSIQCLYYILLAGILYLLDSMFSSSLSLEQMFEYQSINTHSQSGRVVMTAFLINSLFGSFCLKYIVERSKKCLDHSATVTFIHFIIVWIVSGFPKTVVWWAIQLIGMVIMAMIGEYLCMRKELMDIPLQRGKDLDSTPITIPPSPHTSSPIMNPKNNSNGNSGSNNNNNNIFSNSINSSGGSSSSINSIGNSNNPYQPIELEILTHQDKQDEHDD