lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm. Endoplasmic reticulum.
Sequence:
MAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVLSPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGSGSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLRILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPFRSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGGPSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSPTAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTSTGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPERGGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQSAESSDSLSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTLGLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQCPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSDALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGALEETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPNSAFLHTLDQQKPRVSKSWRKIKNMVHWSPFVMSFKKKYPWIQLAGHAGSFKAAANGRILKKHCESEQRCLDRLMVDVLRPFVPAYHGDVVKDGERYNQMDDLLADFDSPCVMDCKMGIRTYLEEELTKARKKPSLRKDMYQKMIEVDPEAPTEEEKAQRAVTKPRYMQWRETISSTATLGFRIEGIKKEDGTVNRDFKKTKTREQVTEAFREFTKGNHNILIAYRDRLKAIRTTLEVSPFFKCHEVIGSSLLFIHDKKEQAKVWMIDFGKTTPLPEGQTLQHDVPWQEGNREDGYLSGLNNLVDILTEMSQDAPLA
The following text describes a protein:
Function:
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
Subcellular Localization:
Host nucleus inner membrane; Single-pass membrane protein. Note=Also localizes at the transient membrane of perinuclear virions.
Sequence:
MAGLGKPYTGHPGDAFEGLVQRIRLIVPSTLRGGDGEAGPYSPSSLPSRCAFQFHGHDGSDESFPIEYVLRLMNDWAEVPCNPYLRIQNTGVSVLFQGFFHRPHNAPGGAITPERTNVILGSTETTGLSLGDLDTIKGRLGLDARPMMASMWISCFVRMPRVQLAFRFMGPEDAGRTRRILCRAAEQAITRRRRTRRSREAYGAEAGLGVAGTGFRARGDGFGPLPLLTQGPSRPWHQALRGLKHLRIGPPALVLAAGLVLGAAIWWVVGAGARL
The following text describes a protein:
Function:
This protein may be a precursor of secreted proteins and peptide hormones.
Subcellular Localization:
Secreted.
Sequence:
MASVKLFFIAILVVALSLNTSAAVLNPSSTAKPRFETKDRKLSAGALQSLAG
The following text describes a protein:
Function:
Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes (By similarity). Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes (By similarity); [Circumsporozoite protein C-terminus]: In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Cytoplasm. Note=Localizes to the cytoplasm and the cell membrane in oocysts at day 6 post infection and then gradually distributes over the entire cell surface of the sporoblast and the budding sporozoites.
Domain:
The N-terminus is involved in the initial binding to heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes (By similarity). The N-terminus masks the TSP type-1 (TSR) domain which maintains the sporozoites in a migratory state, enabling them to complete their journey to the salivary gland in the mosquito vector and then to the host liver. The unmasking of the TSP type-1 (TSR) domain when the sporozoite interacts with the host hepatocyte also protects sporozoites from host antibodies (By similarity); The TSP type-1 (TSR) domain is required for sporozoite development and invasion. CSP has two conformational states, an adhesive conformation in which the TSP type-1 (TSR) domain is exposed and a nonadhesive conformation in which the TSR is masked by the N-terminus. TSR-exposed conformation occurs during sporozoite development in the oocyst in the mosquito vector and during host hepatocyte invasion. TSR-masked conformation occurs during sporozoite migration through the hemolymph to salivary glands in the mosquito vector and in the host dermis; The GPI-anchor is essential for cell membrane localization and for sporozoite formation inside the oocyst.
Sequence:
MKKCTILVVASLLLVNSLLPGYGQNKIIQAQRNLNELCYNEGNDNKLYHVLNSKNGKIYNRNTVNRLLPMLRRKKNEKKNEKIERNNKLKQPPPPPNPNDPPPPNPNDPPPPNPNDPPPPNPNDPPPPNANDPPPPNANDPAPPNANDPAPPNANDPAPPNANDPAPPNANDPAPPNANDPAPPNANDPPPPNPNDPAPPQGNNNPQPQPRPQPQPQPQPQPQPQPQPQPRPQPQPQPGGNNNNKNNNNDDSYIPSAEKILEFVKQIRDSITEEWSQCNVTCGSGIRVRKRKGSNKKAEDLTLEDIDTEICKMDKCSSIFNIVSNSLGFVILLVLVFFN
The following text describes a protein:
Function:
Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSFYPILRGPAKQESPPPPPAPKKRRKTARACLHCQKAHLTCDEGRPCARCIKKNMGDQCVDGKRKQAKYLVGLPPTPPGQATQQKQQQQQQQQQAVQHGMGPPDTDFGSSAANLEYSILSNILGRGDTSSPPDFFPAQSPHMPSPMSIPGLHMEEEGSQTAGTPQGSPTDIYTSITKPYAYTTGFHALIAYLKSRFEKKELLDVVKSMAFYRPSFIATTQTLQYEDLVFMEKCFQRTLLEFEKYISLSGTPTVLWRRTGQIAAVGKEFCVLTMRSQADLLSQFIIECMDNKSVVQYFDVFSELAFEDSRGTITTTFGLTKPSGEVVNTACSLTIKRDVFDIPMMIVGNFLPIL
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MSRKRITVKAKHPNPLFERWLIEWRDKAKENDSKMQHCFSMALKSLKNYPLPLETGKDCKILKGFGEKLCKMLDDKLKQFKANENTDIVTKVTTPKKTKPKEYIPQPGSGAFAILLTLYEKSLEPNYPGHLTKADVIKFGQHLCNVSFTKAGPDTRYTAWSSMKTLLEKNLVVKRGNPAKFSLTEEGTVLADKLFVQKKIEEFQNQDNSLPGPSCSSLSKTNDNKEQHVSPTPCSASNEAVILAPNSFDIILLVDNQELNGSNGDVETDPIIMELKKLNVRFETRNLKVGDYAWICRDFISNHELILPYIVERKRMDDLGCSIKDSRFHEQKFRLKQCGIPNLIYLVESYGKNEHVGLPLTTLYQAATNTLVQDNFIVRFTNDTKASCGYLASLTKFLEKLFKPKTLVGCQKDDLQEFTLDDDLIQLMRFADFNISSSKTRHFKIKEMFVKQLLKIKGVSVEKALAVVEKYQTPKNLKLAYSEISEVEGEKLLSTLQFGANKKFGPVLSKTVYKFFCNNY
The following text describes a protein:
Function:
Protein adapter that acts as an essential executor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells. Recruited to young transposons, which are specifically marked with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3), via its association with SPIN1 chromatin reader, and associates with the de novo DNA methylation machinery and repressive chromatin remodeling complexes. Following this, PIWIL4 engages with nascent transposable element transcript to direct piRNA-directed DNA methylation. Not required for piRNA biosynthesis.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MSQAGDVEGPSTGDPVLSPQHNCELLQNMEGASSMPGLSPDGPGASSGPGVRAGSRRKIPRKEALRGGSSRAAGAAEVRPGVLELLAVVQSRGSMLAPGLHMQLPLVPAQGRALTSKRLQVSLCDILHDSCPRKLCSRSAGLPERALACRERLAGVEEVSCPRPREARDGGMSSLGCDRRSPTLSKEEPPGRPLTSSPGPVPVRVRKKWRKQGAHSECEEGAGDFLWLDQSPRGDSLLSVGDPPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGSPCGPVRFPVPSGGESLGSAAQAPPQSAALCLGASAQASAEQQEAVCVVRAGSDEGRAPAQDQEELEAKAQPASRGRLEQGLAAPADTCASSREPLGGLSSSLDTEASRACSGPFVEQRRSKGTKNLKKGPVPCAQDRGTDRSSDNSHQDRPEEPRPGGCPRLEEVKIPHGVKLVCYLGSGPVIQLLGAISHGQAGGQLPPKLEVLEDLMEVSSPSPAQRLRRKKRPVVQGPAGCQVFQPSPSGGTAGDPGGLSDPFYPPRSGSLALGDPSSDPACSQSGPVEAEEDSLPEQPEDSAQLQQEKPSLYIGVRGTVVRSMQEVLWTRLQELPDPVLSEEVVEGIAAGIEAALWDLTQGTNGRYKTKYRSLLFNLRDPRNLDLFLKVVHGDVNPYDLVRMSSMQLAPQELARWRDQEEKRGLNIIEQQQKEPCRLPASKMTHKGEVEIQRDTDQTLTLEDLVGPQMFMDCSPQALPIASEDTTGQHDHHFLDPNCHICMDWEPSNELLGSFEAAKSCGDNIFQKALSQTPMPAPEMPKTRELPPTEPQDRVPPSGLHVPAAPTKALPCLPPWEGVLDMFSIKRFRARAQLVSGHSCRLVQALPTVIRSAGCIPSNIVWDLLASTCQAKAKDVCVIRLCPHGARDTQNCRLLYSYLNDRQRHGLASVEHMGMVLLPLPAFQPLPTRLRPLGGPGLWALPVSPLLSPGLEVTHSSLLLAVLLPKEGLPDTAGSSPWLGKVQKMVSFNSKVEKRYYQPDDRRPNVPLKGTPPPGGAWQQSQGRGSIAPRGISAWQRPLRGRGRLWPEPENWQHPGRGQWPPEPGLRQSQHPYSVAPAGHGFGRGQHFHRDSCPYQALLRHLESLVTMSHQLQVLLCPQTNSSIPRPLQHLSSALAAPEPPGPAPDSSLGPTDEAGSECPFPRKA
The following text describes a protein:
Function:
Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MRDDDPPKSTTLIVSRTFHPKKYCGYLDDFPFETSEPTKGFAITQTEIEARIIDRCDKLIQFYQYQLESLPDVTAANIISFNNAALADRRRQVFYSILLAINNSPKQIALKAFSDLYNLRKLWINKRYYNTFVAVPQTKILCKCCKFEDCINPALYGSDFCYWHILNDPNQQMYEKCPNCGQPKLFSTLCKSCSKSKANITIYPIISNGNPPPPPPIKKSIIPTVTPITPVSRTVLPQEQKARSYKQPVHFVSPEKFVLPPASIIHPVNHGDILSGPIYKLKSNRDLTEDERKMIAAAALDFKPRNPN
The following text describes a protein:
Function:
Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity.
Subcellular Localization:
Cell junction, adherens junction. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line.
Sequence:
MNDISQKAEILLSSSKPVPKSYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDEEEVSSKIEKAYVPKLTGTVKGKFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLVTVVPVKSHKTSGKIKKNFEDLEKEREEKERVKYEEDKRIRYEEQRRSLKEAKCLSLVMDDELENEAKKESFSPGKLKLTFEELERQRQENRRKQAEEEARKRLEEERRGFEEARRQMVNEEEENQDTENIFKAYRPGKLKLSFEEIERQRREDEKRKAEEEARRRIEEEKKAFAEARRSMAVDDDSPEMYKTISQESLTPGKLEINFEELLKQKMEEERRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFELSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEEDVDVKPAKKSEAPFTHKVNMKARFERMAKAREEEEQRRIEEQKLLRMQFEQKEIDAALQKKREEEEEEEGSTMNGSTIEDEEETRSGAPWFKKPLKNTSVVDSEPVRFTVKVTGEPKPEITWWFEGELLQDGEDYQYIERGETYCLYLPETFPEDEGEYMCKAVNNKGSAASTCILTIESKN
The following text describes a protein:
Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MASALSINELFTLRDAQVPEGSCSPEHLTVSSSSGICVCVTTGEAANLTVVNTVNPQATKTFPIQAQHAIQHRKNPNIVVLRTPVLLQTLDVSTMTPYGRFDFPNPIGVDYWGWATDEKLALVCPDAVYFWNCMTGEFSPGFARDVSLTSTYSNSRITDLAVSSDADWVAITALGTDQANHTQGMIQLYCFSRAYTRMLSGQCVTFVDWQLDATRPKTTLLAYAHKPTGSQEITINIMEPAPQVGADGASISGFTTKAVQATVSAALVGVDHPLFLRGKEKYGFLYMFSKQGNVTLVDIYSGLLIYQGPISGEMVFAIGTCYEGGTFSDTHDFIGITTDGRCYGIGVDKINLVNYVMTKRGQPDVAYAIALRTGIRGADSLFQQKLDGYLGQYQWSEAAELVKIAPAGVLRTKATIDRFLAGAAFTAPGAPTPIMIYLTRMLENDGKLAIEEESMELAKFLVQTSNVSTIETYIKEKRFFATEGLGDYLASVGLEQPSFTTYANAGCHEKAIAWLIAHNQYAIIPQYAQKFPEYTPDYPRIISQALKQAEQRPDGASTIESIYQFSLSITQALDATTDGDKILDIADCFADIGRVNEATTILLEVCKRYNYSDDTVIYQSMVIELNRGVNQAVVDAIQAKGVLARINRAEITKRSEESGLYQRAFEFCDSDAECRRIASTYAAKLGKSIFSSPRWYGAYIKRASRFSNPTDDVIKSLFAFQQQMLEITIGGERIYADHVAMGFALSPIVVSNVSLCVTVVKVFEKYGMGNSEALYLFLSMIAPTCLDSSIHNFLLRTILQLDSKTLELTHIVAEDQYLDPNECFTIMTTTTPASPDAFLQAFLTFCERFHLGKKLGLFLTDSITNKVLGKDTFFTLNAATIVEAFIGGHGVAQAHDLLFGLFEGGVLAVPERPALDAVFSADMLSKLMEKPAVQAGCDINKVVDACFTSSRTLKVGRSLLEKRLASGTTDTFVHTAFAKLHMEERNGNAKRLLMEDPYIDHALIGTFILESPTHRTDDFLVDLAMTSLTIGAFGPTTAGADFSDHIINGECARMLVLVAYAGSAYKELAERLLLHKCSELWQLALVGVMNEDPASDVIKAITQGGMRPMSMHRDMLLQVLAHSPPIPLDTLSDAQIFVLSSSILAIKNESDAIPRYLQAILEKIITSPGSVHASNPGMQNLLIVTALNTKDYPKVSALIRSADMCYDQDVIAKACVETAKKNEYPPLYEDAFEVFHRAGRPIDAIRVLLDNISIDRGITYANSVGLPEVWSLVGSAQLEKASAYASEDNGRFALKFACDAIASYLTGRWTADYRNLIITSFKVSKAFMHTHSVEVRSELAALLEYLRMARVVVAQKGETSSQAEIDTAVMYCLARLDDYGALSEFLESVNPRDSTVIPNRGGIKEVGEKCFAEEHYKAAKYFFEFVGDWSRLSLTLVKLRCLKEAVEAATRAADPECWKAVAAECLEIRDFELAKSVFLNLVLVESELPSIVQYYEEYGFIEELLEVLEAGAEQPQAATYTSMETNIFTILAILYCKYMWIVRKTDPQRLQTYIKTHGNKIHIPTLLHWTRETRLWGEYAYLLAASRDFDKAVVEMIAHPPSSFNHDVMKKVIGRVSNPELVAQVVSFYIEYSPEYLCDFLKACQLGVPNADGSPGIPAALDPIRVIAMVRSYDCVPMIKSYLELFVGAHNQEINETLIKIYLESYDDEGLRRLIAATTAYDAHALLDNLVSEDQTDDMRKLAVGLYGRLNRYDEGIKFGLQNWFYEDAAECAADSGQIEHCEALLRLVCSSQFPTPKIRKEVFAVILIRCGHCIRPDVVMELAWVNRMTDYMMPYMISTLQRYGSAVRTLAGSIAEARGMIPAQQAPQQH
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as a non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVMAQNTTMLVNVGVVLDLEHLAGKKGLSCIKMALSDFYATNSHYKPRLVRHTRNSMEDVVGAAAAALINSNFSFESPFRNTALTLIKNVELQAIIGPTTSTQAGFVIELGQKAHAPIISFSASTPSLASIRRTYLFRATKNDSTQVGAIAALIQAFGWREAVPIYVDNEYGQGVIPYLTDSLQAIDTRIPYRSLISFSATDDQIAEELYKLMSMQTRVFILHMLPSLGSRLLTKSKRANSCKITQELSMLSRAFTNYGHMMLLLHLAIDKAGAAKIDFQKANTSSNSTIDLTTFGVSLNGPDLLQALSNTGFRGLAGDFLFVNEQLPSSTFQIINVIGDGARGLGFWTPQKGLIKKLNSVAVTNLYSTSESNLAPVIWPGDSSSILKGWEIPTKGKKLRILVPVKEGFSEFVKVTRDPRTNTTTVRGNCIDVVNAVSMSRRAVFNRRRRRGRLQQNPTPFLGFLYLQMGFIFAKQKLLPFTAEVGDTAIIANKSLYVDFIFLYTESGESMIVPIKDNNRERVVSNLARLVVMIWCFVILILTQSYTTSLTSLLTVQQLMPTVTDVHQLINNGEYVGYQEDSFVLGILRGLGFHESKLKVYNSTKECNELFVKGTENGSIAAALRKYYTRSCS
The following text describes a protein:
Function:
Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MEVLGLFRLEVSGPMVTVALSVVFLALLKWYSTSAFSRLEKLGIRHPKPSPFIGNLAFFRQGFWESHMELRKQYGPLSGYYLGRLMFIVISEPDMIEQVLVEKFSNFTNRMATGLEPKPVADSVLFLRDKRWEEVRSVLTVAFSPEKLSEMTPLISRACDVLLAHLERHAQSGEAFDIQRTYCCYTTDVVASVAFGTEVNSQEAPEHPFVEHCRRFFASSIPKPLLVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVQDVRHSAATVGVEKFDIVRQVFSATKCPANPPRRHSPRPLSKPLSVDEVVGQAFIFLIAGYEIVTNTLSFATYLLATNPECQEKLLEEVDCFSKEHLAPEYCSLQEGLPYLDMVIKETLRMYPPAFRFTRVAAQDCEVLGQRIPAGAVLETAVGALHYDPEHWPNPENFNPERFTAEAQQRRRPYTYLPFGAGPRSCLGVRLGLLELKLTLLHILRKFRFEACPETQVPLQLESKSALGPKNGVYIRIVSR
The following text describes a protein:
Function:
Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Lysosome membrane; Single-pass membrane protein.
Sequence:
MKLPLSPSTEPVATEPLGMALLSSILAAWSYISENPERAALYFVSGVCIGLFLTLAALVMRISCHTDCRRGPRRRCLQDRECSDSSDSEDGSEDTASDLSVRRHRRFERTLNKNVFTSAEELERAQRLEERERIIREIWMNGQPEVPGTRSLNRYY
The following text describes a protein:
Function:
Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis.
Subcellular Localization:
Apical cell membrane. Cell projection, filopodium. Cell projection, microvillus. Cell projection, ruffle. Membrane raft. Cell projection, lamellipodium. Membrane; Single-pass type I membrane protein.
Sequence:
MTITWTIIVLGAFLHDMAYAQSETTIPTASESHSTSNRSVVTDATVSTTVHKATNAQTTEAQTTSIPAGPTSQATHPPTSAPTTQSDPNNNQGSTALPSTSTLYMQNVSSAQVIPTGVDPNTSFSPTTQYTLTDSPKSVTQPHSSDQASTSNPDNLNTPTSTSERTTQRVSTEQTTAYSPAKQDRPTISDPATPANSTTELITSKPDITTDKKTTTGTTTQLLTTAKPNARSFVSQSLQTTIVPQSTTAPIKTSQPSDLRKNFTHPVYDLSSSSSSTERNIVRETCKKLGQNLKGNCSVEVEINNNQLIATITINANQAIPLENYNPPETNENENSNKEPVQDTIPDTLIAILASCGALVLILCGFAAYCTYHRRSYRKNQQHLTEELQTVENGYHDNPTLEVMEVQPEMQEKKLALNGEFNDSWIVPIDNLLKEDIPDEEDTHL
The following text describes a protein:
Function:
Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina.
Subcellular Localization:
Nucleus inner membrane; Single-pass membrane protein.
Sequence:
MVGDGEEQAPPHAPELKHRRKSPRFAAEAEPDSGGAQEGGEPAFGSPGSLTRPPIRACRVVGGSSSSFLPESPAKEKVNDYDVSEPKNPAGDQPNAYTPLKESKADFSEKTQEYHATKSQSRSKFRDQPSTGKQSQHLAKKDGSQSGFPKGWTLLLVLLVSISLFSILWIKGLNLPDATLSIRNTQILQAFRTRMKKLRNTYQSQDPNLWKRTHVFLERHLNTSHLHLEPAILLFTAGQEAEKALRCLSDEIANAFAFSQNGTTIKINGADKAILDSDVVKLEVDDELSSGFREGKKVAVVHRFELLPAGSTLIFYKYCDHENAAFKDVALLLTVLLDEQSLRRSLTLKEVEEKVRDFLWTKFTSSDAPSSFNSIDTDKLSGLWSRISHLVLPVWPEKGLPIEGCT
The following text describes a protein:
Function:
Catalyzes the reversible NAD(+)-dependent oxidative deamination of L-phenylalanine to phenylpyruvate.
Sequence:
MTLTAERHDTAQPENAGVFERTDFPTDTAHEQVTFFQDPATGLKAIVAIHDTTLGPALGGTRFYPYADEAAALKDVLRLSRGMTYKSAIAGVDLGGGKAVIIGDPATGKSEALLEAYARFVQTLGGRYITAGDVGTNSDDLDVMGRATDYVVGRNTSAGGSGDSAPMTALGVFQGMRAAAQAKWGTASLAGRTVGVEGTGKVGYQLIKLLLADGASVVATDVNAAALDRVARDFPEVKIASSVIGQELDVYAPCAMGATLTDESVAAITAQVICGAANNQLAHPAVEHDLGERGITWVPDYVANGGGLIQVAGERLGTSADDVRAQVEKIFATVVQILDVAKRDGILAGAAADAVAEARIAAAR
The following text describes a protein:
Function:
Thioesterase that has relatively broad substrate specificity, hydrolyzing primarily medium- and long-chain acyl-CoA substrates to free fatty acids and CoA.
Sequence:
MSDILNNLIHLLKLEKIDDLIFRGESQDLGFRQVFGGQVVAQALSAAMQVAPEDRILHSCHAYFLAPGDSQYPIIYDVETLREGRNFSALCVKAIQHKNTICHVTASFQVPEKGFEHQNTMPNVGAPEDFTDENVMLQKVAQTLPEPLNEKFAAERPFEVRTKYLNNPFNGTKLPAEQYSWFKTNGETPLDIKIQQCLLAYFSDFHCILTALHPHEKGFLQKGMKVATIDHSIWFHRPFDLNHWHLHAIESNNAFGGRGLAQGQIFSQDGQLIATTQQEGLIRFSE
The following text describes a protein:
Function:
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Subcellular Localization:
Nucleus.
Sequence:
MPKYYCDYCKSYLTHDTMSVRKSHLQGRNHIKFYCDYYEAKAKETNIWNPSSIPYEITLEKLNRYSDAKKSNGSSEDNMDIDKKENSSDHNKGNVVNHSDAGNDNDDDDDEMIFLPPPPNLSGLPLPPPAVYNNQKEYQKAILRQTLTKS
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors.
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane; Multi-pass membrane protein. Note=Central core structure of the nuclear pore complex.
Sequence:
MKIQAGQLGLDDNDVPGPLPDTDSKPSSQSQNDTPMFKLGNFESPVLKELSRRTVNKEMETQRIMTNVIAFAFWNLLVKFIKFFWNNTHVGRQFCNRLSRIHLYMLTFHTLKKANIIYHTTFSWLNAELLDYLFHLLISLNILFSLWKLLSTVKVSDLNLTDRQKKLLGVDMQSSVDTGLQPQHPHYVSTSKISQMAQNKTHIPQTNLKNHPAYLFKGLETPLKARQREMAEEQTKLQSQSLHTKNVFGTLQRHSGISSTLVSANNDNNSPHTPVTRKGYIPSSKYAYMMNSQSPRGKI
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MQQPARRTWTDQELAISGFERFALELEFLQCLANPLYINWLATKQYFDNPAFLNYLKYLQYWKQPAYAVHITYPHCLFFLDLVQDADFRNAIKDFSYAEHIRQAQDSFFRNFHSNRVAEAEGKATAAPAADGDGGAGDAMD
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of dicarbonyls. Exhibits narrow substrate specificity, with preferential activity against the dicarbonyl substrates methylglyoxal and phenylglyoxal. May play an important role in the detoxification of methylglyoxal.
Miscellaneous:
MISCELLANEOUS: Identified as a multidrug-resistant tuberculosis (MDRTB) immunogenic protein.
Sequence:
MTGESGAAAAPSITLNDEHTMPVLGLGVAELSDDETERAVSAALEIGCRLIDTAYAYGNEAAVGRAIAASGVAREELFVTTKLATPDQGFTRSQEACRASLDRLGLDYVDLYLIHWPAPPVGKYVDAWGGMIQSRGEGHARSIGVSNFTAENIENLIDLTFVTPAVNQIELHPLLNQDELRKANAQHTVVTQSYCPLALGRLLDNPTVTSIASEYVKTPAQVLLRWNLQLGNAVVVRSARPERIASNFDVFDFELAAEHMDALGGLNDGTRVREDPLTYAGT
The following text describes a protein:
Function:
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
Subcellular Localization:
Cytoplasm.
Sequence:
MLGNLDKYQIILASNSPRRKELMSGLGVDYVVRTLPDVDESYPADLAGAEIPEYISREKADAYRSIMQPGELLITADTIVWLDGKVLGKPEGREGAVEMLRSLSGKSHQVFTGVCLTTTEWQKSFTAASDVEFDVLSEEEIRYYVDKYQPMDKAGAYGVQEWIGYIGVKSISGSFYNIMGLPIQKLYGELKKL
The following text describes a protein:
Function:
Required for assembly of the mitotic spindle. Interacts with spindle microtubules to produce an outwardly directed force acting upon the poles. Following spindle assembly, CIN8 and KIP1 apparently act to oppose a force that draws separated poles back together. This force seems to be mediate by KAR3 (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Note=Spindle microtubules that lie between the poles.
Sequence:
MLEQAEKLMKRNSSGAMSAPQSKPLARSRSSTMPTTTQKRVRSSQQSEGEPEYNIKVYVRCRSRNEREIREKSSVVISTLGNNGREVILTNPGTGSNKTYTFDRVFGVESDQESMFNQVARAYINEMIEGYNCTVFAYGQTGTGKTYTMSGDITMMGSSEDDPNFVLLSEHAGIIPRVLVELFRELREVSEDYSVKVSFLELYNEKLRDLLVDDKDVSLEDHNFNGMAPPESIRIYDSLKTDRTSPNGYSIFVKGMEEMYIRSAQEGLKLLMDGSLKRKVAATKCNDLSSRSHTIFTITTNVTKIHPISGEQYVKVGKLNLVDLAGSENINRSGAENKRAQEAGLINKSLLTLGRVINALVDHSQHIPYRESKLTRLLQDSLGGKTKTCIIATISPAKISMEETVSTLEYATRAKSIKNTPQVNQLMAKESCIIEYIQEIERLRKELRASHSKEGIYITQEKFETYESNSILVEEQQAKIDNLQEQLRRLKEKFLEQTKLIKEKDGQIKELDVANRKYLEQSKDLTIYINGIHSKLEDYEHTMIGIHNNNMKLLEDINDNRGNIHEDLLAKVDHIETCNLIISREITSLISIRNVLQAYSDRFKTVLGGVFEELQEKLTQVGRTTEESQLDVDLSFVDEKFEEVTDIIKATCENLVRTMDEHVSNMKLETTDLTSSCASLLEKECQALHGKLQKYVESMKQELNSTLQEMVRDLDMKASSMLNVVQCTKDGLISHKKELEADLESQKREHFDIAQTMEEQLQKIVGKERQNIQESMKASYDFLMKQMVETELRQKNFEESIVSKVKGLLSHSNNGMSKMSSYAVGRLYDSAIGGVNSIENTVSSATFSMKNDLQEFQMDISPICDSRRFGDEFTAVETRISEAIREELTPKLQDITSKACNLIGLGVQDINQKALGVSDDQRRELRSVINNTNNHADRLRSEIGTLVNYVSQEHRDNIMQISQTQDEILQEQIASIGRTFDVLGNINKPDANVRTSVPIEHELNSAINELPPLYMPQRPLSLCSHGRQLLDEAYSGNENLSPSTGKFSNFPTPCGDMSAQTPTTPMPVPDQPLTKMPVPQTISSLRSLRRLTMDICEHSADMTLGSIHESQKAMDSSRRYTLEPRLFEK