lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MHGHSVAEQAVASEPKQATGRLESDDPLASSLIFLASYHGRAVSREALLGGLPILDGRLSVPLYDRAAQRAGLQTEAVKRDIADIPALVLPAVLIMKNGTTLILLGFDKSGSSVKVLNPSLKAGIPELHAIQTISAGYTGYAFFVRATVESNARAVAAGDLPRSHWFWSVVKLHWRGYGHIALAAFLINMLALATPLFTMSVYDRVVPNGALPSLIALSIGMGLAIAFDFIFRTVRSRMIDVTGKTIDVILAANIFEHVMGVKMAQRPASVGILANQLRDFDSVREFFTSGSVVSATDLLFAMLFVGILFVIAGPLAWIPLVMLPVMLLIGLALQRPLDRAMKRQQAEAAARHGVLVESLSGLETIRATGAEARMQTAWERSVAATARSGEDVHFWASLALTSANTAQQLTSLALIVVGVFLILDGKLTVGALVAANMLAGRVLAPIAGIASVITRGTQTLSSLKAIDRIMSLERERSPARAYVSRQIREGAIAFDGVSFTYPNAPGKALDKVSFKIEGGEKVGIIGRIGSGKTTVGRLLLGFYEAQEGRILVDGVDSRQYDPSDLRSGVGFAMQDTELFFGKLRDNIALGKPEATDEEVLAAARLAGVETFVAGHPMGYDMPISEGGRSLSGGQKQAIGLARVLIRKPRILFLDEPTAHFDIRSEAEFLERLRALREEQITILISTHRLSLLNMVDRLLLFDNGRLIADGPRDKVLALLQGKPAPSTPSQTPMPAAAEQPVSPMARTNVV
The following text describes a protein:
Function:
Interacts with pom152 in the core structure of the nuclear pore complex (NPC). Involved in the export of mRNA.
Subcellular Localization:
Nucleus, nuclear pore complex.
Sequence:
MGDYLLSWSWILDAFETSDENLSQNKFEELLDARIAAFQQIESPVTGTLNSNKTTEGEEAKLSIYDSSHSISKSQLESVKKISDITGYNEAQVAYVLLVHQYELNTQYFSQLDNDSVLAQEFQRRYYAEIISCWKVLAFLLQACTDADSKWHKMATRLIVSIFQTAQRSGENAQSTTPSIFCVRIIDYLSKMTSQAAPASLTFNGEEAISQWYFFHFNLQLQLLRVIFLSTYSLVVCNSEMAISWFNCMKKTRYLHDQEFMHLDIDTGFSMCKEITNVAIIISINFISLEKQVLSFKDNPSFFMLSGNTIISLHDMITQLSNDSIGAAVSLTWGIALHLLSNSPDNIPLIQNSSVVSSKILQNPQNSFQALIIAALKYDPFTLIHRIISSLEDDPYIDGYSKIMATLFSSAVSYVKFSDSTMLCATTLFKTPQVYQLFENNDSVTRLLNFARARFPFEYSQFVLLLIPTFACLTSKQLVSSELLHMTTFTQSLPSGFKAYEIIPEPNVTGNALIELQESLHLDSYGFFFPNAERSLPKGTRGRIVSVDTYPPVVMWDLNYSLWEAVGISLNYIVRNGLINSHKSFVLTVLSSSVPLFQTDVSGACELVHLASEGLDGELDFINVICDLLDYFLSLSVIEDADYQICVSSLRLLREFTRFAATDVWAYVTRSLVCVGSEKGISLEDVIFDYESINGVYDFTLAFFDLYEILLDNCISTSVVPDDFSIRLKTDFVKRAMRFLCEVFANYLDWKYARIIQQYQIGHRFASLITKLLNVTFGIEYFNPKTTVNKKTLPLRELSHYIVQRFLVQQDSNRYLHPLLSVMDLINLLYTDIFSTISSPRAKAAKMWLISSFCAMKTLICLRGFLNLKPSELERELFSRSPDLFNCLPRLLCCIAPILQLLSALILAPWPSETPSLLAYMINSTDIVGRVCIQILTNPIQSTNIEGSVWKFLSSIMKGQQQGLAVLLFSGKKFPLDRMKSLNHNVDVQLTSKSLISLAEKRLDSFSINDILSQVPVFEFIFLSRNFWTASLGNLQQEANFWNRIVDAIKLPLTVKLDGLSSVAQADLYILAAHATRITAIQLHMSKLNKSNSSKKIIIDPLKDSMKDLVQHAFTITAYDSNIHNALTRAFKHENGDLHISDLRNTGLFPLRYGDNYFYNIKLAKNMLLNTEDTSFKISMMMSANENLSLLDAQAALLRSWSIFICAFVEFVKEDATLSILELKIMKWVLKSLAEDTIDVNVVQELSAERAALVFRISQQTLAIPISNEVKEHLQSILLLTWKAITTTKFSIYEDSNGEMAYYRPLLHVLYNTLNRLLSEEKENLSLSVGFVSGLLQLCHRKLSQLFEKAVINPTIEVYGDIVLLNSLHKCIVNSHLIRGLQSLYISYINDSFSVDNCLRLFSWSHSLLVDGQPYFADAALSFLLICSSSPAGAEQIVMNGFFYSIMESPLSTALSTGGLGLDGSSIQYKIWIRGILPLLFNIVKFLGNRIMNDMREFVLLAFPQIQYALLNWCQPPSSISLASIDESFMIVLLFDLLQQFNPALLQEIRLAELKIEMLEASTI
The following text describes a protein:
Function:
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Sequence:
MGRMHAPKGLSQSALPYRRSVPTWLKLTSDDVKEQIFKLAKKGLTPSQIVILRDSHGVAQVRFVTGNKILRILKSKGLAPDLPEDLYHLIKKAVAVRKHLERNRKDKDAKFRLILIESRIHRLARYYKTKRVLAPNWKESSTASALVA
The following text describes a protein:
Function:
Regulates plasmid DNA replication by modulating the initiation of transcription of the primer RNA precursor. Processing of the precursor of the primer, RNAII, is inhibited by hydrogen bonding of RNAII to its complementary sequence in RNAI. ROP increases the affinity of RNAI for RNAII and thus decreases the rate of replication initiation events.
Sequence:
MTKQEKTALNMARFIRSQTLTLLEKLNELDADEQADICESLHDHADELYRSCLARFGDDGENL
The following text describes a protein:
Function:
Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MKKKSDGDTRNFTPIRFALLCTAILLSMALLLGRVAWLQIVTPSKLVKQEDMRSLREVTTASPRGMITDREGRPLAVSVPVNAVWADPKTIISKGGVGYNERWQALASALHLSLSTLAERVNSNPAGRFIYLARQVSPQQAEWIDKLNLPGINLREESRRFYPAGHVAANLIGFTNIDGQGIEGIEKSFNAQLTGKPGSRLVRKDKFGHVIENITEVNPVPAHELQLSIDERLQTVTEDALDNAVIWNKAESGAAVLINIPTGEILSMASYPDFNPNNREGAQLDDFRNRAISDTFEPGSTVKPLVIMTALQQGIVQPDSVIDTHPFTLDGHRIRDVGYYPELTLTGILQKSSDTGVSHLSLAMPVQKLMDTYKSFGFGVPTGLGLTGESSGLLPKRRYWSDLDRATFAFGYGLMVTPLQLAHVYATIGSFGIYRPLSITKVDPPVIGTRVMPEELVHEVEHMMESVALPGGGGTKAAVRDYRIAVKTGTAKKIGDDGKYVDKYVAYTAGVAPASNPRFALVVVINNPQNGAYYGGAVSAPVFSQIMGDVLRLENVEPDGMPADSDHLLVMHGSHVAVPGS
The following text describes a protein:
Function:
Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).
Sequence:
MTTSAASQASLPRGRRTARPSGDDRELAILATAENLLEDRPLADISVDDLAKGAGISRPTFYFYFPSKEAVLLTLLDRVVNQADMALQTLAENPADTDRENMWRTGINVFFETFGSHKAVTRAGQAARATSVEVAELWSTFMQKWIAYTAAVIDAERDRGAAPRTLPAHELATALNLMNERTLFASFAGEQPSVPEARVLDTLVHIWVTSIYGENR
The following text describes a protein:
Function:
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Subcellular Localization:
Cytoplasm.
Sequence:
MALKTCKDIKSIKEEIHLKKLEIMKLKNKQYFEVTVGFVPTMGYLHQGHISLVEKAKSMNDIVVASIFINPTQFNANEDLSTYPVDLESDSKLLNQAETDLLFLPTPDIVYPKGFSTYVQVESMSDVLESKSRPGHFRGVATVVTKLLLIVNPSNLYIGQKDAMQCICISRLVQDLNIDTNVHICDTIRENTGLAKSSRNSYLSQDEQQQASKIYQILTDFKNRISSFNDRNHFIDEITKLLESNPNVKVEYVSLASHENGLEILDQFPPPPKSNLSIALFFNGLKRKTRLIDVIIL
The following text describes a protein:
Function:
Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTDIRHRKKGSVADPDESATSIGLFPTDKKPIGKAISSDLYLAVDQSGNELVSNFALFFVTALAVLTRTWMLHYPGEVVFDEVHFGKFASYYLRREYFFDVHPPLGKMLLAGVGYIVGYDGHFLFDHIGDNYAENNVPYLALRLWCALCGAAVVPISYMTLREIGVSVMGAALGALLLVFDNALITQSRLILLDSMLMLFCTMCIYFWVKFYKQRHKVKMVGLFTMGAIGIATLFDLWEILDIDRGVTMRKVIKHFAARTLCLIIVPFGLYLLPFYIHFSILTKSGPGDAFMSMRFQEGLTNNNNTAGAIAVMYGANITLVHGSTNHYLHSHYHNYPLRYDDDRVSSQGQQVNAYAHSDVNSLWNMVPVDPDLYSLAKKYVPTKKEEERDIRYVRHNDIVRMYHVSTKAYLITHDVASPMTTTNMEMTVVRDAESERRYNETLWRVAIEDADPGDKLKSKKFLVKLINVIHNVALMTNKGALPDWGFKMQQTNGNKNIKDKSNIWRVDKVEHERIVNGTELGEETQKEKSGKPPLSFMAKFIELQVQMVAHNSKLTKPHPYSSPPSHWPFVVRGISFWEKKDGIRQIYLIGNPIVWWLSIASVLFYVILWVVDRICLRRGIDDFGHSARRWWDRAIGFLIIAWAMHWLPFFLMGRMLFLHHYLPAFIFSTMVFAAMFDFILRVAFSGSYIPIRSTSDGGDDKIIKSATKKQEKLTSIWFAQAATPGMVYYILALVIFCAFGYVFWDFSPFCYGSGFPSVEILRAHKWMTSWDLQYA
The following text describes a protein:
Function:
Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.
Sequence:
MVIDFNRLNPGSTPATTGRTGSTAAGRPDATGADKAGQAATSAPKSGESVQISETAQNMQKVTDQLQTLPVVDNDKVARIKQAIADGTYQVDSERVASKLLDFESQR
The following text describes a protein:
Function:
Transcription repressor required for the formation and development of tiller buds and panicles. Required for tiller formation and female sterility. Required for the early developmental stages of axillary meristem formation. Plays a role in maintaining the axillary premeristem zone and in promoting the formation of the axillary meristem by promoting OSH1 expression. Does not seem to be involved in maintenance of the shoot apical meristem (SAM).
Subcellular Localization:
Nucleus.
Sequence:
MDHMQQQQRQQVGGGGGEEVAGRGGVPVCRPSGTRWTPTTEQIKILRELYYSCGIRSPNSEQIQRIAAMLRQYGRIEGKNVFYWFQNHKARERQKKRLTTLDVTTTTAAAADADASHLAVLSLSPTAAGATAPSFPGFYVGNGGAVQTDQANVVNWDCTAMAAEKTFLQDYMGVSGVGCAAGAAPTPWAMTTTTREPETLPLFPVVFVGGDGAHRHAVHGGFPSNFQRWGSAAATSNTITVQQHLQQHNFYSSSSSQLHSQDGPAAGTSLELTLSSYYCSCSPYPAGSM
The following text describes a protein:
Function:
Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CGAS and SNAI1. The ECS(SPSB3) complex catalyzes 'Lys-48'-linked ubiquitination of nuclear CGAS in cycling cells, leading to its degradation. Recognizes and binds nucleosome-bound CGAS: ubiquitination and degradation of nuclear CGAS during G1 and G2 phases is required to promote low intranuclear CGAS abundance before the next mitotic cycle. The ECS(SPSB3) complex also mediates ubiquitination and degradation of phosphorylated SNAI1.
Subcellular Localization:
Nucleus.
Sequence:
MARRARSSRAWHFVLSAARRDTDARAVALAGNSNWGYDSDGQHSDSDSDPEYSSLPPSIPSAVPVTGESFCDCEGQNEATFCNSLHTAHRGKDCRCGEEDEDFDWVWDDLNKSSATLLSCDNRKVSFHMEYSCGTAAIRGTKELGDGQHFWEIKMTSPVYGTDMMVGIGTSDVDLDKYHHTFCSLLGRDEDSWGLSYTGRCCLGYGWGWQCHRPPRLTPLLLTGLLHHKGDKTSFSSRFGQGSIIGVHLDTWHGTLTFFKNRKCIGVAATRLQNRRFYPMVCSTAAKSSMKVIRSCASSTSLQYLCCYRLRQLRPDSGDTLEGLPLPPGLKQVLHNKLGWVLSMNCSHWTSPAPPPGTAAPAAERDSRETRPCQRKRCRRS
The following text describes a protein:
Function:
Mediates feedback control of cholesterol synthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MPQWKDTKLSRCVQRSAAGPMPRLESGAWSCSCAARARHAARPGEAAPKADAMQSPSPSAGRAEREASGGAATTWRQHLVQRSVVLFVVGAFMALVLNLLQIQRNVTLFPDEVIATLFSSAWWVPPCCGTAAAVVGLLYPCIDSHLGEPHKFKREWASVMRCIAVFVGINHASAKLDFANNVQLSLTLAALSLGLWWTFDRSRSGLGLGITIAFVATLITQFLVYNGVYQYTSPDFLYIRSWLPCIFFSGGVTVGNIGRQLAMVIIV
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLESELSRKWDQCLADAVVKIGTAFSSGTGLGMAYSNCQHDFQAPYLLHGKYVKEQEQ
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVQTTDFYNTCLSDFKEITHKPTNFLQISDPLCEKIKTSLKKCYDYAKAEEITRTDALPQLNVKNFDLEQIWQQIELQNENLTTKSVTCVSRLIAGKSRLLFKNLDKSGISDDGSEVEENDDGSEVEENSEHSDTSGDESNDLNDVESSDDEVETTETSKPVKRSIVDDDFFKLDEMERFLREEEKKEEGVDSGNDSESEASVDLFEADSDDSEDHAKTAKYKDFFVQNEEKPSTFELRQKRLAKKIEEIEEEAIQDKTWQLKGEITAEKRPQNSLLEEVVEFDMTTRPPPVMTEQTTMQLEDIIKRRIKDKVFDSVERKAKPVENLLDYKKKIVLDQEKSKESLAQIYEKEFLQAQEPEDREKEEPELHKEINSLMRKLFTKLDALSNFHFTPKPAVPDLKIISNLPAISVEEVVPTAVSDATLLAPEEIQKKPKGDLVGVKERTTTDKKRERRKKKLKQKIHAKNKKEPVKKAKNVNLMEDKGKRIKSSKEFFNQLQEQVQVSQIKRKAAPTTNKKSAKKLKL
The following text describes a protein:
Function:
Plays a central role in chromosome cohesion during cell division by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms.
Subcellular Localization:
Nucleus. Chromosome, centromere.
Sequence:
MARLNEQAMSSVALSTDNLELLRRKFLRQNRDIARVNSTQSLRIRGLENECARLLSENLELRGQVLRLEKELQDNAARRVADHALEVKAKMETQLAELSSLLASLGEPPSKRRLSEERRYAQPRPSVHRSPPLRRARQEADQELLAEQEGRLPPIYENKTYARATMNSEEILALCMQADDSNDSPDIGPPPVSRFVEDDMVIPCSPSPNKNAEAEETETTEQVEESPRALQVPPSLSPPKLDYDRRPNMILFSPPKESRVAEPSKMFSPPPMEPPKQSTSAVPSETIRAGLKRKLNGDNQNEPNKATKLQQGKENGNETGIKKGLSARDPHKRKSIKETATKPRAPLSAKSTNEHIVSPKKPAKPHQVADDFKPVKVHKASKGKEKVDLPAPDKKSAVEETQGNSTSAFTKVEILPPALEPTPEVAEIPETDILITPGTPERASESTVVTHDTPPPAHISSNGETSRPSRRARAAISYTEPNLRDKMRRPTKELFDAVSGEGKFLHRPTSQQQQQQRKGDESAPTSVSKVKVEPSPAVDISSLTSSALFEKEKEKEPQPDEGILSPNGILPSSVDLGRRRRASSFSTAAPAMTIPSVQEQSTLNLPAADETDENAAVEAQIQKELSNSITTRPRGGKGRQSMSRSVPTIPTENYEHEDAQLSTNSASVDLYDFASCASPDSAAPQLEATTGDVPVNKKAPKGSRRASSAASTETTATASAKPRSSRKRASMLVPKKSLWAEELAQEEEDEEDVGNDSGGSLSKGRASRRRSMML
The following text describes a protein:
Function:
CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition.
Subcellular Localization:
Nucleus.
Sequence:
MTSIIKLKVFSGAKDEGPLCYLLQVDNDYILLDCGWDERFELKYFEELRPYIPKISAVLISHPDPLHLGGLPYLVAKCGLTAPVYCTVPVYKMGQMFIYDLVYSHLDVEEFQHYSLDDVDMAFEKVEQVKYNQTVVLKGDSGVNFTAMPAGHMIGGSMWRICRITGEDIIYCVDFNHRKDRHLSGCSFDNFNRPHLLITGAHHISLPQMKRKDRDEQLVTKILRTVRQKGDCMIVIDTAGRVLELAYLLDQLWANQDAGLSTYNLVMMSHVASSVVQFAKSQLEWMDEKLFRYDSSSARYNPFTLKNVNLVHSHLELIKIRSPKVVLCSSQDMETGFSRELFLDWCADQRNGVILTARPASFTLAARLVELAERANDGVLRNEDKHLSLLVRKRVPLEGEELLEYKRRKAERDAEETRIRMERARRQAQANESDDSDDDDIAAPIVPRLSEKDHRSFDAIENDSHCFDIMAKWDNQQKASFFKSTKKSFPMYPYIEEKVKWDDYGEVIKPEDYTVISKIDMRKGKNKDEPVVVHKREDEEEVYNPNDHDEEMPTKCVEFRNRIEISCRVEFIEYEGISDGESTKKMLAGLMPRQIIIVHGSRDDTRDLYAYFTDNGFKKDQLNTPVANELIDASVESFIYQVSLSDALLAEIQFKEVSEGNSLAWIDARIQEKESIDNMLVAGASQLTIEDSLQEDAVEVVEEDVIPMETFQDDQNKQEASEENVAEGEKSNGQSKENDENASSIPIETQPKIRGTLILTPLPKKQIPVHQAIFVNDPKLSEFKNLLVDKGYKAEFFSGTLLINGGKCSILVERLDSKWRVLSQKTFTNFGSCSTTSLLFCK
The following text describes a protein:
Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Subcellular Localization:
Secreted.
Sequence:
MALWTRLLPLLALLALWAPAPAQAFVNQHLCGSHLVEALYLVCGERGFFYTPKDRRELPDPQGESSPLTPRSHPKGTGYLASVDPSQSQDQHLCGDELVNALTITCGDRGFYNPMAPLEQDDLQEEEVEMDEGGLQALTLEGLLQKRGIVEECCTNVCSLYQLERYCN
The following text describes a protein:
Function:
Molecular chaperone which mediates the proper assembly and functional expression of the nicotinic acetylcholine receptors (nAChRs) throughout the brain. Essential for the proper folding, assembly, function and surface trafficking of alpha-7 (CHRNA7), alpha-4-beta-2, alpha-3-beta-2 and alpha-3-beta-4 receptors. Stably associates with ribophorin-1 (RPN1) and ribophorin-2 (RPN2) (components of the oligosaccharyl transferase (OST) complex) and with calnexin (CANX), both of which are critical for NACHO-mediated effects on CHRNA7 assembly and function (By similarity). Facilitates the proper folding and assembly of alpha-6-beta-2 and alpha-6-beta-2-beta-3 receptors and acts at early stages of the nAChRs subunit assembly. Promotes the expression of the alpha-4(2):beta-2(3) stoichiometric form over the alpha-4(3):beta-2(2) form (By similarity).
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Shedding may lead to a soluble peptide.
Sequence:
MASPRTITIVALSVALGLFFVFMGTIKLTPRLSKDAYSEMKRAYKSYVRALPLLKKMGINSILLRKSIGALEVACGIVMTLVPGRPKDVANFFLLLLVLAVLFFHQLVGDPLKRYAHALVFGILLTCRLLIARKPEDRSSEKKALPESAEEQPSLYEKAPQGKVKVS
The following text describes a protein:
Function:
May function as a coactivator for aryl hydrocarbon and nuclear receptors.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Detected in the cytoplasm at stages I- II. Detected in the nucleus and the cytoplasm, except for the germ plasm, of almost all cells in cleaving embryos (By similarity).
Sequence:
MESISQLQPPMGVNFLNIAPTYIPNTKVECHYTTPFGMKRSTRDWIGIFKVDTSSIRDYETFVWAVPPESSGERSVSHCSVQFQAYYLPRPGEQQYHFRYVDQYGSVRGCSDAFVFGEPRPMEELVTLEDEDSCMDMLLVVPKATFLQNQLEMAQQERNDLMRARLALEEEVILKEKRINHLEATLETSEKSCFSLKEQCQDLVMREQLAIEEQSLLSCQEAELRERILQLQGEIKIMNKKMQEKDRELEGTVAIKLSLENKKVVLKQHLAETTVEIKRYQLQVDSLREKLRSTQDMLSASQQKALLMGEELAAISSIRDRTISDLHKSRLETADLAIKVSDLSVKYKEGMGQWWQEKTALNHSMEAKRDQIVNLKAEKLSLENSLQAERSQRQALQCKLNQETDARQVQLSENRRQLSELKSALKVAQMEKQQLREERQGILQYARSLEERLDKLADELWKEDKMLMEEITDLNPPTLPVDHSDSDDESPGDERVSQQLEACSLDEQDLTINLPGFPCELYKVVINQPAPIACQLQPLPEDNSDSW
The following text describes a protein:
Function:
Appears to function during host infection, and may play a role in suppressing the host immune response.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Host nucleus. Host cell membrane.
Domain:
The CFEM domain is involved in heme-binding and contains 8 cysteines and is found in proteins from several pathogenic fungi, including both human and plant pathogens (By similarity). The CFEM domain adopts a novel helical-basket fold that consists of six alpha-helices, and is uniquely stabilized by four disulfide bonds formed by its 8 signature cysteines (By similarity).
Sequence:
MQFSIVVMAALASLASAQSMDGIPTCALQCLAQAVVTGGCEASDQACQCGPAREAITAAATPCLLSACTDAADLATAASVGNGMCDKYKMGGDDAAPSPSVNTPAAAAPYPTAPAPNGTVPIGTAAAPSPTANTNETTTVATGSAPQNVAGGLAGIFGLVVAAAFAL
The following text describes a protein:
Function:
Plays a critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has replication fork regression activity, unwinds stalled or blocked replication forks to make a HJ that can be resolved. Has a DNA unwinding activity characteristic of a DNA helicase with 3'-5' polarity (By similarity); A deletion mutant does not display the same phenotypes seen in an E.coli recG deletion and is not affected in DNA repair in response to UV light or quinoline antibiotics; however this gene complements an E.coli deletion as well as the endogenous E.coli gene.
Domain:
The wedge domain within the N-terminus inserts into the replication fork junction, where the lagging and leading strand split (By similarity).
Sequence:
MQETDNLLKTLNVKSLLEALLVYTPKGYKDLNLLERFETGLSGVLEVGILEKRNYAKVLKIFAYSKRFYKNLELVFFNYSAFHHSQFKTGESLFIYGKLEQSSFNQAYIINTPKIITKFGKISLIFKKVKNHKKIQENLQKLISLENLKKEGVKENIAHLLLEIFFPTPHFVKDFETNKNFPSQHLNALKYIEMLFYMKNLERKKLQFGAKIACPNNNERLKAFIASLPFKLTRDQQNAIKEIQNDLTSSIACKRLIIGDVGCGKTMVILASMVLTYPNKTLLMAPTSILAKQLYNEALKFLPPYFEVELLLGGSYKKRSNHLFETITHVVIGTQALLFDKRDLNEFALVITDEQHRFGTKQRYQLEKMASSKGNKPHSLQFSATPIPRTLALAKSAFVKTTMIREIPYPKEIETLVLHKRDFKIVMEKISEEIAKNHQVIVVYPLVNESEKIPYLSLSEGASFWQKRFKKVYTTSGQDKNKEEVIEEFRESGSILLATTLIEVGISLPRLSVMVILAPERLGLATLHQLRGRVSRNGLKGYCFLCTIQEENERLEKFADELDGFKIAELDLEYRKSGDLLQGGEQSGNSFEYIDLAKDENIIAEVKRDFLKAASVSRGTFEN
The following text describes a protein:
Function:
Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis.
Sequence:
MASLGANLRRTPQGPGPGAASSGFPSPAPVPGPREAEEEEVEEEEELAEIHLCVLWNSGYLGIAYYDTSDSTIHFMPDAPDHESLKLLQRVLDEINPQSVVTSAKQDENMTRFLGKLASQEHREPKRPEIIFLPSVDFGLEISKQRLLSGNYSFIPDAMTATEKILFLSSIIPFDCLLTVRALGGLLKFLGRRRIGVELEDYNVSVPILGFKKFMLTHLVNIDQDTYSVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCRCKWGEKLLRLWFTRPTHDLGELSSRLDVIQFFLLPQNLDMAQMLHRLLGHIKNVPLILKRMKLSHTKVSDWQVLYKTVYSALGLRDACRSLPQSIQLFRDIAQEFSDDLHHIASLIGKVVDFEGSLAENRFTVLPNIDPEIDEKKRRLMGLPNFLTEVARKELENLDSRIPSCSVIYIPLIGFLLSIPRLPSMVEASDFEINGLDFMFLSEEKLHYRSARTKELDALLGDLHCEIRDQETLLMYQLQCQVLARAAVLTRVLDLASRLDVLLALASAARDYGYSRPRYSPQVLGVRIQNGRHPLMELCARTFVPNSTECGGDKGRVKVITGPNSSGKSIYLKQVGLITFMALVGSFVPAEEAEIGAVDAIFTRIHSCESISLGLSTFMIDLNQQVAKAVNNATAQSLVLIDEFGKGTNTVDGLALLAAVLRHWLARGPTCPHIFVATNFLSLVQLQLLPQGPLVQYLTMETCEDGNDLVFFYQVCEGVAKASHASHTAAQAGLPDKLVARGKEVSDLIRSGKPIKPVKDLLKKNQMENCQTLVDKFMKLDLEDPNLDLNVFMSQEVLPAATSIL
The following text describes a protein:
Function:
Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production.
Subcellular Localization:
Nucleus.
Sequence:
MKGFVDEPNYTIDLLEDGTTLGDVIDNHICEQALAEKNAFFVADLGDIVKKYTLWQNVMTQIKPFYAVKFNNSQAVIEILAALGAGFACTNKSEVALVLSCGVAPENILFTSLCKQLSHVTNAAKNGIDILVCDNETELRKIARCHPNARLLLQIATETHSEGEEMSMAFGSTLKNCRHLMESAKERGVQVVGVKFHISSSCKDMQAYTHALSDARCVFDMGEEFGFNMNILDIGGGFCGSEAQLEEIYRSMRPLLDVYFPPESGVSVIAEPGSYYVASSFTLAVNIIAKKVVARDQYDHPLDVEPSLNDEPAFVYYMNDGVYGSFASKLLEKAIAAPSVHKKSSKEEPVFASSLWGPSCDGLDQVVEHCLLPELEVGDWVIFNNMGANAMGGQSIGDFQKPPIYYLISACDWYEMQDAGVTLESAMKNFLAIPSCFQLGQEDRISAPA
The following text describes a protein:
Function:
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Sequence:
MGIKGLTGLLSENAPKCMKDHEMKTLFGRKVAIDASMSIYQFLIAVRQQDGQMLMNESGDVTSHLMGFFYRTIRMVDHGIKPCYIFDGKPPELKGSVLAKRFARREEAKEGEEEAKETGTAEDVDKLARRQVRVTREHNEECKKLLSLMGIPVVTAPGEAEAQCAELARAGKVYAAGSEDMDTLTFNSPILLRHLTFSEAKKMPISEIHLDVALRDLEMSMDQFIELCILLGCDYLEPCKGIGPKTALKLMREHGTLGKVVEHIRGKMAEKAEEIKAAADEEAEAEAEAEKYDSDPESEEGGETMINSDGEEVPAPSKLKSPKKKAPAKKKKVASSGMQIPEFWPWEEAKQLFMKPDVVNGDDLVLEWKQPDTEGLVEFLCRDKGFNEDRVRAGAAKLSKMLAAKQQGRLDGFFTVKPKEPAAKDTGKGKGKATKGEKRKAEEKGSAKKKSKN
The following text describes a protein:
Function:
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Subcellular Localization:
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Sequence:
MEEAATIGQDTGNSTVSEPMECPRLLQSIEVASLLVRPIHIVGDVLKVLRGCLFSMRGVKNVVNGAAADTAAGDAQACRKFLLDPTFLSPISIPQLSSSCTLVWMRADDVSLPAVLRDKLVLVSQGAESRAEPLQVALTTHTVDVTSKNFTMPELLQMLLPPGITALSGFEQIGHIAHVNLSAEHLPYKMAIGAVILSCNPTVSVVVNKVNSISSVFREFKMEIVAHRHCGGNSKGNSSTHRGGGGSVGVAGSGDHNPRTNAEEEEAQQQQQQLLLATVRQHGCTFRVPYDRVYWNSRLSHEHTRIVELMQRGDVLYDVMAGVGPFAVPAASAGVTVYANDLNPVAAEYLRINADINHIRKDSFHIFNIDGREFMNTILYNDVIANSSRCGRRHVTMNLPAIAVEFLDVFAKRPWIPEPGMKVRESKENPDKRVLFHVYCFSKNVEDFTGDAVRQVTRWLSFELRKENLELVHVVRDVAPKKRMVCVSFTLPDAFWRCRYDNMGTEKQMQTLKRAREG
The following text describes a protein:
Function:
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MRVMGVDPGLTRCGLSLIESGRGRQLTALDVDVVRTPSDAALAQRLLAISDAVEHWLDTHHPEVVAIERVFSQLNVTTVMGTAQAGGVIALAAAKRGVDVHFHTPSEVKAAVTGNGSADKAQVTAMVTKILALQAKPTPADAADALALAICHCWRAPTIARMAEATSRAEARAAQQRHAYLAKLKAAR
The following text describes a protein:
Function:
Acts as a decapping enzyme capable of hydrolyzing monomethylated capped RNAs (in vitro). Hydrolyzes monomethylated capped RNA after alpha and beta phosphates to form N(7)-methyl-GDP. Shows low activity towards unmethylated capped RNA.
Sequence:
MSYGVDILRGKTLYAGKCMLDLFDNNLISYQYRQHEAQLNLSLQEQGWSQIHLLHSNCCPCQNKDLKPLDQNYSKIKLATVAMLCDRDYNFLLTRRHSQMKTFPKSWVFPGGMVEGQQNLESECLREVQEETGLDVLPILSKMELKVMYESIYPTKLEDNQYPIKQTLCMFYEVKINQSYQNVTIKMEENEVDDYKWLSKKQMLEIMNGQTKDHSFLEIAGIYPNSYGSGIGEGHVKAFLHCYA