lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MITRTTLDSGNHAMLKNKNDNWGRKSHRERNISSGPELFRQLFRQLRYQDTSGPQEALVRLQELSRWWLRPDIHTKEEILDRLVLEQFLTILPGDTRTWVLLHHPENGKEAVALVKDVESHFEEQEMEVAAPAQVQDGNLWMGTTSLGASQESLPRPSLGDHFSGRPPSDAATAHLQDPLNVPPTPQVPAGPQEGSTGDLAVAGSPGARLQESMTFEDVAVYFSKAEWTLLSPAQQVLYRNVMLENYENLASLACPFPKPIVISNLEQASWDLQEALVQDLRNTYAGDESQKENKKLAPARESAEADPEASSPGGLQTCAPQQPEFEESAEHDHNREKPGGNSALEIVTGEERGSRYMLGKDVKATAGEAGESVESCYQSTPKPQKIYKCGECSMYFRHSWDLLQHQKTHSGENSLPCGEVGSAFSHTSGSSQAQRIKGENMPHKCKDCNKSFNHRSHLEHHQRLHTRERPYKCKECGKTFRWSSNFARHRRIHTVPKHYECQECGKEFTRISQYIIHQKFHFTKKLHIRNRYGRTFRHISTRNTHRKVHAGEKRYKCKECGKTFTRNRTLLDHQRIHSGEKPYRCNDCGKTFTRNRTLVDHQRIHSGEKPYRCNNCGKTFTRNRSLVEHERIHTGERPYECSKCGKAFNRKSYLFLHERTHNKKKPYKCDICGKDFRWGSGFARHRRSHTEEKYNEVNEQRGVFPHGSDVQHQRIPTEEKSYECQECGKTFTRKRTLIDHQRIHSGEKPYECSQCEKTFSCRPYLIAHQRTHIPKVHQKNQIMENYYKCSQCGKSFSQKSTLLIHQRLHTGERPYKCSVCGKAFRWKSNFIQHQKRHPGMKQHKCQECGKVFSQKDILLAHQMIHSGEKIFKDQYGGKKNRNTKRLIEYLQRRDCEKPYKCTKCGQSFSSASVFSLHCKIHTGGKTYENDNADIFPQNSSLTSHQEFQTREKVYKCNMCDKAFPKKSQLIMHDRFHTRERPYRCNKCGKKFRWSSNLSRHQKSHIAE
The following text describes a protein:
Function:
Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MGFAEELQCPNSHAALLRLQDVELRVMETMKKSFIQRAKSDKEYSNMLHQVSVQVEKLDHSPTPGLSEYSSQLNESWTTLVSQTENLSQILRKHSEDLNAGPLNKITILIREKQQLKKSYSEQWQLLNQDYIKTTQQDIEKLRCQYRSQVKETLQSKRKYQEACRDKDRDKAKEKYVKNTWKLHALHNQYVLAVRAAQLHHEHHFLYSLPTLHESMQSIHQEMVQILKNIMLEYSEITSLVQEEVASLHREIASSVIRISPAQEYDSFLQMNRSVSELPPIVTFDTSLLEETDDLEEELQLNDLTVESVQHTLTSVEEELASVTVAIESKEDIVKQLHSDIATEERTTDCKEKINLLAKRHALRDALLQYHMTLCNKNKVQGQREILKRKMNTIGSGDPPPALQLQDDNQSISSVERECAKKTLENIKNHISGIFRPKFSLPPLLPLVPDVQKPLSQQNWYHGAIPRTEVIGLLVKSGDFLVRESQGKQEYVLSVLWDGQPRHFIIQNVDNLYRLEGEGFPTIPFLIDHFLKTKQAVTKKSGVIINKAVVKDKWVLEHEEVILGERIGKGNFGEVFSGRIRADNTPVAVKSCRDTLPPDLKDKFLMEARILKQYSHPNIVKLIGVCTQKHPIYIVMELVQGGDFQTFLRNEGPKLKVKELIRMSENAAAGMEYLESKHCIHRDLAARNCLVTEKNVLKISDFGMSREEEDGVYSSTGGMKQIPVKWTAPEALNYGRYSSESDVWSFGILLWEAFSLGSVPYAVMSNQQTREAIEQGVRLLIPDNCPDEVYNLMLRCWEYDPKKRPNFSIVHQELVNIRKRYR
The following text describes a protein:
Function:
May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.
Subcellular Localization:
Early endosome membrane; Single-pass type IV membrane protein.
Sequence:
MEYNGGTTADPNQLAQCITSNIQKITQCTAEIQRVLSQLGTPQDTHELRQQLQQKQQYTNQLAKETDKYIKEFGSLPSINLQRQRKIQKDRLVNEFTTALTNFQRVQRQAAEKERDFVARVRASSRVSGGTTDESFREGTLVSWDSQPQTQVLDEEITEDDLRLIEERESAIRQLEADILDINEIFKDLGMMIHEQGDVIDSIEANVETAEVHVQQANQQLSRAADYQRKSRKKICILIVVLVLGVTVLGLVIWGATKE
The following text describes a protein:
Function:
Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome.
Sequence:
MNDTDLSTFTGRSLLIDQLSSVTQGTPVLDFIDKLRIHFYTTIRQNLLKIDLKNICSLHDLTDQLSDFWLVYEQSVLESPILSPELDRILTCFRCLCRRYLPISVIESVLTEYLDQVLKVWLESKTNPCLDMEKFFQLCEKFKQLGLSSVLKERFVYVLQLHVGSLLTTRYAMSWEQSVYHEALEWIRTEFGVLVEHVFSLSNPAVLVQLDHLVSQILAHLRSDNILDIVLHYPNSLGAIEDLRLVARQKQQRQYLTETFVKDCTSSILTASSDSSYILLFYVSTIRCFVALDPPGVLLDKAAKPIRSFLNEREDAYKCLVSLLFVDGEKGLRSELSQIPTENIDSTTDRFDNYHWMPDPIDAAPDFKKPTDRDVVGSLISIFKSKEPLVKELQLLLADRLLQLTDYHYEVEAKNIEFLKYRFGETVLQMCSVMLNDIENSRFIDQSIHMENYVSKGLHVTILSRLFWPTLSVRYFHLPGPLKKELDAYAEEYRERKRKRELVFLPNLGSVELEIELEDRTLTLTVTPEQAAFISLFEETSTLHIEKAAELLDQPKEIVERHLKFWLHHRVLTDIGDDRYRVRETEAETATETVLDEIQGVSAVQSEAESSAAEMRVYWSFVVGMLTNLGALELERIHNMLTMFIPPPNGYTRTQSELREFLALMIKEEKLEFTGGAYKLK
The following text describes a protein:
Function:
ATP-dependent transporter of the ATP-binding cassette (ABC) family which transports various molecules including bioamines, neurotransmitters and metabolic intermediates. In the eye and probably in association with w/white, required for the transport of the eye red pigment precursor, guanine, into pigment cell granules. In Malpighian tubules, involved in guanine uptake. Probably in association with w/white, involved in aging-induced intestinal stem cell proliferation in the midgut by regulating tetrahydrofolate transport.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MQESGGSSGQGGPSLCLEWKQLNYYVPDQEQSNYSFWNECRKKRELRILQDASGHMKTGDLIAILGGSGAGKTTLLAAISQRLRGNLTGDVVLNGMAMERHQMTRISSFLPQFEINVKTFTAYEHLYFMSHFKMHRRTTKAEKRQRVADLLLAVGLRDAAHTRIQQLSGGERKRLSLAEELITDPIFLFCDEPTTGLDSFSAYSVIKTLRHLCTRRRIAKHSLNQVYGEDSFETPSGESSASGSGSKSIEMEVVAESHESLLQTMRELPALGVLSNSPNGTHKKAAICSIHQPTSDIFELFTHIILMDGGRIVYQGRTEQAAKFFTDLGYELPLNCNPADFYLKTLADKEGKENAGAVLRAKYEHETDGLYSGSWLLARSYSGDYLKHVQNFKKIRWIYQVYLLMVRFMTEDLRNIRSGLIAFGFFMITAVTLSLMYSGIGGLTQRTVQDVGGSIFMLSNEMIFTFSYGVTYIFPAALPIIRREVGEGTYSLSAYYVALVLSFVPVAFFKGYVFLSVIYASIYYTRGFLLYLSMGFLMSLSAVAAVGYGVFLSSLFESDKMASECAAPFDLIFLIFGGTYMNVDTVPGLKYLSLFFYSNEALMYKFWIDIDNIDCPVNEDHPCIKTGVEVLQQGSYRNADYTYWLDCFSLVVVAVIFHIVSFGLVRRYIHRSGYY
The following text describes a protein:
Function:
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
Sequence:
MRAKVRAALDALYMKRLVRELEGRPRPQHIGIMLDGNRRWAKMSGIDDPREGYRAGGAKVLDFLRWCDSAQIEHVTLFMLSDDNLARPEEQLNPLIDIIAEVVEQLAAPGNPWPVEAVGALDLLPAESASRLKTATAATQGRKGGTKVDVAVGYGGRREIVDAVRSALTEHSSQGGDIDEFIETFTMEHISKHLYSKTRSESDLIIRTSGEQRLSGFLLWQSAYAEVHFCETYWPDFREIDFLRALRSYSLRERRYGR
The following text describes a protein:
Function:
CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin).
Subcellular Localization:
Cell outer membrane; Peripheral membrane protein. Membrane.
Sequence:
MRALAGLLCGLLGLVPGAAAYEPDVFGTTGQVAGQAVYDLGGSGLPCRGGPPPTELSLEEAIERILCHDPQTRLAWANAKAQAAQVGIGKSAYLPRLDGRLDASRGYSDMDYRDAPYLSGDGHRHRRGASLQLSWVLFDFGRRSAALRNAQQLLLAANASQDATLQNTFALAAQAYYDALAAQRSLAASRQVAELAAQNLEAADAKYRAGAAALSDRLQAQTALSQASLAQVRDEGALSNALGVIALRMGLAPDTPLRLSGELEAQPDTGFVKAIDEMLAEARREHPALLAAQARLKAAAASVEESRAAGRPSLALSANLARSHSDQAMAFNGDTRERDRSIGLQLNIPLFEGFERTYQVRNALARREASEAELADTEQQVSLEVWNNYQSLSVETRSLARTRELVEQSRQSLEVVQGRYRSGVGSMIELLNALTAYASAEDQHIRALGNWQTSRLRLAASLGRLGFWSLR
The following text describes a protein:
Function:
Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. May be involved in lateral roots and nodules formation.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein.
Sequence:
MKNSVSDHSFYIDSDEEVDAGKDLDKDEDDNDGNVSDSSDSSAENQQQTKPGSYNTSWPQSYRQSIDLYSSVPSPSIGFLGTPTLSRLGSSFLSSSLTRRYTPETLPTVTKPLLDEQQQQQRRSSHSLLPPIPSRRSSIRKDEKPSKVSHELPISHQCSYGQSVLNGINVLCGVGILSTPYAAKEGGWVGLSILFVFSVLSFYTGLLLRHCLDSEPGIETYPDIGQAAFGNAGRITISIILYMELYACCIEYIILESDNLSSLFPNAHLSLGAVELNSHILFALLTTLAVLPTVWLRDLSVLSYISAGGVIASVLVVLCLFWVGLVDGVGIQSKGTTLNLATLPVAIGLYGYCFSGHAVFPNIYTSMARPGQFPAVLLTCFCICTLMYAGVAVLGYKMFGESIQSQFTLNMPQGLVATKIAVWTTVVNPLTKYALTMSPVVMCLEELIPSNHSKSHIYSVCIRTTLVVSTLVVGLVIPFFGLVMSLIGSLLTMLVTLILPCACFLSILRRKVTRFQVVLCIIIITVGVISSAIGTYSALSKIVESLRH
The following text describes a protein:
Function:
Could enhance the fertilizing capacity of bull spermatozoa upon interaction with heparin-like glycosaminoglycans present in the female genital tract. Exhibits both simulatory and inhibitory actions on the release of pituitary gonadotropins.
Subcellular Localization:
Secreted.
Sequence:
MALQLGLFLIWAGVSVFLQLDPVNGDQDEGVSTEPTQDGPAELPEDEECVFPFVYRNRKHFDCTVHGSLFPWCSLDADYVGRWKYCAQRDYAKCVFPFIYGGKKYETCTKIGSMWMSWCSLSPNYDKDRAWKYC
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSDTSMSAFKKQASIWLPITAVLAILGSSLYLLLFRRYAKLMVMATIVGSVGFGVLFSIVCFATGAVPFGIILLIMTALTALFYWWIRGQLRMCADLLAIAGRGLTENLGLVPAALGIKLAGLCVLVYGAAGFFAALNIGHAGPSMSVVSYVDEGVEQRVCLDAALNQVSCCAFYTKGWAGAYAFFAWCFVAWSAMLIMQIKLYTVADTMAQWYFSAASGANSSAAVGSAAQTAGSVKLALKHCLTSSFGSVAFAAAILALIRMLRRAMERAARNNVICCILNCVMQPLLALAEKFTRFATIACAITGQPFVPAAKAVFDTLKRNFLQTYSLWWVPDTVLQFAVTLMSLTWAGIVFFASYGAAKGGLGQDAWGMAFGVAFCAFGIMFYTLLFVAGLLLDVVNTLYICFALDKDQRRVTHPEIHAIYNQVPGLAVQQPDGNIVYGAPEPHHAPSPAQPPAYPSYPPAGGYAAPGGYATATYPAPGAYPGGPYPGGGAADYASSYPAAYPPAPVVQPPPQPIGGYGAVPSKDQI
The following text describes a protein:
Function:
Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation. May be required for the formation of ADY3 and DON1-containing protein coats at the leading edge of the PSMs during meiosis II.
Subcellular Localization:
Prospore membrane. Note=Localizes to precursors of the PSM and to the leading edge, which cover the ring-shape opening of the PSMs during meiosis II. Some fraction colocalizes with DON1.
Sequence:
MRSSGTYENDPSGEITSTSPKQSKQKKPTKFRERMRRWLQNGKNNNHQGEEDVPEIFNKNFYPQTGMTAFNNNDNGEVQDVTNNFFLPSEDESGPVQSSVKTFLTGNNDEDSNFQQNQNPKQKSELPKSPYRQKPTQEIALLKDLFVTNKYDDPYLNSSTRFGNITSTFPSSLSLRTVTLQTIKKRIDCISAKKKEVWKTEEKFLKDILMWLQSSNFEDPDTISLIHEIEKIFEEDIHFEQNVSDCLKEISNNFEYICMRETQLINEGNILKNDLKKYAKAREHKGEKHEDTEVLREKVISSQKSFDVTKRHYKHAISITTRQLFMNLAFEYYENCSDMKDISRKYLQESLSTLQTIDTLSFSEELEKIRKRRFDKFWAKTNPDPTNNIQKFVNMRTGVAGFNDSLMNHLYGKLSFGVAPVEEELQNSQPEHTDVPENVWNEVLSDYNSMDGNPITSNKFLSAKELEPDQLVELLAQEKEEKEAKNISSSTAEVPSISQPEIKKENLESNDSLILRSTKRNVNVNAASLRNLSIKKTQVKPESASEESKVLAAALNDAKQNLDENVWRTPI
The following text describes a protein:
Function:
Proposed to be involved in DNA replication and to participate in the activation of the pre-replication complex (pre-RC). May be involved in chromosome condensation.
Subcellular Localization:
Nucleus.
Domain:
The zinc finger-like domain binds a zinc ion and is involved in self-association.
Sequence:
MGPAQKSGTDISIDDEEEILALEKLLGAAENENTKSAESEKAKPTAPILVPKLREDNSFANAFTFEKIVKPEKQKNAAIIKEPELDSSDDEEVKNFLERKYNEYGSDINKRLKQQQENAYESKVAREVDQELKKSIHVVTSTPQPLKNPHNPIKRQSAVSTTFQRPPPVAAAVASTSQSSAPVSAVFTDPVFGLRMINPLVSSSLLQERMTGRKPVPFSGVAYHIERGDLAKDWVIAGALVSKNPVKNTKKGDPYSTWKLSDLRGEVKTISLFLFKEAHKSLWKTAEGLCLAVLNPTIFERRAGSSDVACLSIDSSQKVMILGQSKDLGTCRATKKNGDKCTSVVNLTDCDYCIFHVKQEYGKMSRRSELQSATAGRGINELRNKVLGKNEVFYGGQTFTAVPARKSAKLITKERDRLSMLAGYDVSPFAHTANHTSKPKTAEPTKIPYAERGGPVSRLAGGVEASRKQRVQDLERLRLLKEENERFEKKKQAEGHVLGSDNKKESEAGTPAVSMPTTPVPDKFKNRGFSFDASLTPKLSGSENFSFEINVGSRQAQNAKLKAAALLKKKPLEKINPNSTRGSESGKRRAIDELNEKFSSSAKRQKIDEDDRELMRKSRIEKIMAATSSHTNLVEMREREAQEEYFNKLERKEAMEEKMLTTYKMPCKAVICQVCKYTAFSASDRCKEQKHPLKVVDAEKRFFQCKDCGNRTTTVFKLPKQSCKNCKGSRWQRTAMIREKKILTGRETLSVRGDEETFMGCLAGSANLNLLVPDEE
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing by facilitating excision of a subset of introns (By similarity). Plays a role during early embryonic development. Involved in the dorsal-ventral embryonic patterning. Probably acts as a negative regulator of the NF-kappa-B (Rel) signaling pathway.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MPKEKSKHRHRSRSRERRDHRSPDPRSSRNRDRDREREREKDRDHRDHRDKERDQRREREKDKSRDKKREHKSRRRRSSSSSSSPSSSTSSSVPGAPRSPLVKSPMKLLQTLEARRLVEQKDRQRKKEELKAHETPEEKRARRLREKQAKEQRRRERMGWDNEYQTYSNEDNPFGDSNLTSTFHWGKKLEVEGLSNLSTKTVEVLSLQKQLENRRELEKVKKRRQERELERQVREDDLMMQQRAKEAVQFREWQRQEDQFHLEQARLRSEIRIRDGRAKPIDLLAQYVAAGNEPLEECLEMQMHEPYVLLNGLPVEELEDLLVDIKVYEELEQGKHIDFWNDMITIVQDELQRQQKLEAENSSLNQRRDGIHQAVVKDVADIFRGKNAQQLEEMRHRIEAKISGRADGVDISYWESLLSQLKAHMARARLRDRHQALLREKLSLLKRENDNETLQEKVAPQVKEEEMETQDAEDPEVEEGSPEDEEDPLNELRKTVRLYQAGNYSPRYIREEDFTGRRAQNEDVDEPEAEGLLYEEEDDERRTQRQRLLILHPERVDNNQLTPQELRMRNEAKQGMQGDEAEFSVETTLDAVPQLATDKYRPRKPRYFNRVHTGFEWNKYNQTHYDMDNPPPKIVQGYKFNIFYPDLMDKSQTPQYFLTPCADNGDFAVLRFHTGPPYEDIAFKIVNREWEFSYKRGFRCQFHNNIFQLWFHFKRYRYRR
The following text describes a protein:
Function:
Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).
Subcellular Localization:
Secreted, cell wall. Note=Covalently-linked to the cell wall.
Sequence:
MRGAILATAAAFAGTAVADMHMRRHAHEGLHHRALHASSAVPEEECGCTTEVITYWGEPTTIPLSVPTSTVTSETTETVHSTSYSTVTVTATSSAAPVETPSETPSPTPEVTLPTAGVTSYSETGTYTIPATTITVTDTTTVCGATTTELPSGTHTYGGVTTIVETATTITCPYATVKPTGSTVTSVIETTTYVCPSAGTYTIAPTTTFVPTSTVVVYPTPETVTPGTYTNPGTTITVTRTEDVYVCPYTNGNVPTSVPALPTTSAASTTTAVPSSSTTTSSATSVPTGASGNKMGMTFTPYNNDGSCMAKNDVLEQVGLIKGKGFSHVRVYGTDCHTLEYVGAACSTHGLKMILGVNVEGSTGFDGARSQFKDITNWGQWDLVSLIVVGNEVVTSNIASAAQLASFVSEGASAFSAAGYTGQVTTAEPIDVWLSNGATLCPVVDILGANLHPFFNPEFTAAEAGTLVSNQIKDLKQVCTGKDVINLETGWPNAGSANGKAIPGQSQQTTAIKSLVEKVGDVSVFFSYADDGWKSKFATSDKYNVEQHWGCIDQF
The following text describes a protein:
Function:
Controls actin polymerization and depolymerization.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MESRIIEIDPNCVNEFEKLKKKYKIESIFLKLNDNFNLLYVEKTLSKISQDDFLESIPVDQPRLIIYKKYSNNKIIFIRWIPEIVQDTIEYSYSNASTAILELLIGINEYMEVKDLIQLSNL
The following text describes a protein:
Function:
Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
Subcellular Localization:
Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Endosome, multivesicular body membrane; Peripheral membrane protein.
Sequence:
MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTSPLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASSAPPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQPGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFVNRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVEGSPMHGVYMSQPAPAAGPYPSMPSTAADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAYSSYQPTPTAGYQNLMTTLPSQDASLPPQQPYIAGQQPMYQQGETHTRGPFSADRTRTQVSGQIRASASVDRKNREFT
The following text describes a protein:
Function:
Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MIPPVQVSPLIKFTRYSALLVGMIYGKKRYDYLKPIAEEERRIEAEEKKKREELERIAKELAEASEDSILK
The following text describes a protein:
Function:
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P receptor is critical for cell migration and epithelial integrity during vertebrate embryogenesis. Receptor for the chemokine-like protein FAM19A5 (By similarity). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTTCRLFAGFCQAVTMSKYSQYFNKTLIQVHYLTAKEMTAEELRDRIESKQSLSSLNILFVVICSIIILENLLVLIAVFRNKKFHSAMFFFIGNLAFSDLLAGSAYIANIFLSGPRTFHLTPVQWFIREGTAFIALSASVFSLLAIAIERYIAITKVKVYGSNKTCRMFLLIGACWVMSILLGGLPIIGWNCINNLDDCSAVLPLNTRYYIRFVVTIFSIILLSIVILYVRIYLIVRTSHQEATNSPAYALLKTVTIVLGVFIICWLPAFTILLLDTSCKMKQCPILNNAGIFFSFATLNSALNPLIYTLRSKDMRKEFLRVLCCWGLLNCGRPPHRCMVPLKSSSSMEHCTNKHEHQSIPIMQDCTTCV
The following text describes a protein:
Function:
Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MGGGLLAELALLGLLALGGAGLLVSGEPAAASAPCPRGSSWSSDLDKCMDCSSCPSRPYSDFCLGCTVPPPSAPLLWPVLGGSLGLALTLGVLSGLLVWRRCRRREKFTTPIEETGGEGCPGTALIR
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MESTNRLSAIQTLLVIQRWIGLLKWENEGEDGVLTWLKRIYPFVLHLPLTFTYIALMWYEAITSSDFEEAGQVLYMSITELALVTKLLNIWYRRHEAASLIHELQHDPAFNLRNSEEIKFWQQNQRNFKRIFYWYIWGSLFVAVMGYISVFFQEDYELPFGYYVPFEWRTRERYFYAWGYNVVAMTLCCLSNILLDTLGCYFMFHIASLFRLLGMRLEALKNAAEEKARPELRRIFQLHTKVRRLTRECEVLVSPYVLSQVVFSAFIICFSAYRLVHMGFKQRPGLFVTTVQFVAVMIVQIFLPCYYGNELTFHANALTNSVFGTNWLEYSVGTRKLLNCYMEFLKRPVKVRAGVFFEIGLPIFVKTINNAYSFFALLLKISK
The following text describes a protein:
Function:
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEKEQEQGSVASSASVTIPSTTSVSTSTSAGTLSNSSSRQQTVPQISVYGGITDRQTVQVIQQALNRQPSTVAAQYLQQMYAAQQQHLMLQTAALQQQHLSLAAVQQASIVAGRQSCSQHGSTSQQTVASQTTINLATSPAARHLISRAQSGSSVPVCIGQQAVLLGNSSTPTLTASQAQMYLRAQMAQQTNLVQVARSLGRAVPLSSQLIFTPTASVTAIQPEAPAPSINTPPTSGQVQNLALRSQQGALTSTLSQSQLQSLSVKQSVASVTGQSVARLKGLGAEPSPQGTAAKASPAETSSETTAKNDKTSDLTTSVCPSVTSVAGHPFISTAYTQIQTHQLLQQHKQQFVIQQQPQILQRGQAQLLEAAAIHPHTVQAVAIQSALPAQPQQCPIPLLPKVPVTCQQATIFHSTTVSQQALAQNGQAHILTHTKAPPLQLTAVKCQIHPVQIQQGVASQNVPDKDTPVLLEPQLLSIPIQEPTRTELRQSDKESQVKENTQGSVNVKAGVGSPPAMTSGSGNNAPTVTGSAPQNGESKPPPQAVVKPQILTHVIEGFVIQEGAEPFPVERPSLLIENLKQKQHHAYSDLQKHNADSEMEDLSLQELNNQPEPVRTCEFCGNVDFAFNFKRSKRFCSTVCAKRYNVGCTKRMGLFPGKSSPEDTKKPKASDESPKNCSTETRKRNPSIQTTTGASLLSPHPSHPSHGESSQCSDMSSYEEPISPLSNSSFGAPIEHEESFDHSRELTPLLTQHFLASDPTKWNVEDVYEFICSLPGCHEIAEEFRSQEIDGQALMLLKEDHLMSTMNIKLGPALKIFARISMLKDS
The following text describes a protein:
Function:
Phosphorylates both NADH and NAD(+), with a preference for NADH. Anti-oxidant factor and key source of the cellular reductant NADPH (By similarity).
Subcellular Localization:
Mitochondrion.
Sequence:
MIRAANGFRISVRNTAVCLAPNFRQLKGFSIINLGSLQYFRYNSVYSKSIRLVNTLENRIVPVYKECASPQSIGGKSNLKQLQWPKPPKNILILKKRMDERVDHCFETLVQHLQQTYPDICIITETDVAKKFSYLNLYTWTEISDLEQKVDAIITVGGDGTILHAASLFARSGMPPILSFSLGTLGFLLPFDFGSFQTAFADFYNSRSFVLMRMRLRVAMKTKLYNESIYAMNEMHIHRGLSPHMAVLKVFVNDKFLTEAVADGLIISTPTGSTAYSLSSGGPIVHPSINALLLTPICPNSLSFRPVLFPDTFKISIETSNKSRVRPQLSIDGRPLGLTDIGQRIDITSVKDNAIPCIIRSHKEDDWVSDIVSLLRWNHPFHRKGW
The following text describes a protein:
Function:
Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MNVEQVKSIDEAMGLAIEHSYQVKGTTYPKPPVGAVIVDPNGRIVGAGGTEPAGGDHAEVVALRRAGGLAAGAIVVVTMEPCNHYGKTPPCVNALIEARVGTVVYAVADPNGIAGGGAGRLSAAGLQVRSGVLAEQVAAGPLREWLHKQRTGLPHVTWKYATSIDGRSAAADGSSQWISSEAARLDLHRRRAIADAILVGTGTVLADDPALTARLADGSLAPQQPLRVVVGKRDIPPEARVLNDEARTMMIRTHEPMEVLRALSDRTDVLLEGGPTLAGAFLRAGAINRILAYVAPILLGGPVTAVDDVGVSNITNALRWQFDSVEKVGPDLLLSLVAR
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. ORC binds to multiple sites within the ars1 origin of DNA replication in an ATP-independent manner.
Subcellular Localization:
Nucleus.
Sequence:
MSAILQYDSVSKGTYSVKPKPTESLGNEFSEGLFVPLIGGKEPIEYVKLRENLCTKVLNELEEITTHTTYDSNARVLRQLCEHASEPVDETGLLRTAIVCDKSSNSMHLKFYEQLKDDMEKIGWKNFVVLNLKAHRDLKSCFRVIKGGSFGLGVLSYDIEKLDEKTVLVLEDVEDCDRRLLSSLVEALSSLVRHSKLQGCLYTIFNLKIPLEMFDTSLDSKFLSNVKTKVFNMKASTEILESLFTSIEESLSLKFGWRTRRFFRSMFYERSWSVERVIECIRYSILTHFYGNALSIIEHLIYQKDFHLISPLHLTTLRTVPSFQRHIEQRLEIGDLESINYVEKMLNDDTYFQEMVIQMCENLLYRERLLRTQAKIWHELEMAVKTTTRISFADYLETFLQGDWLSSPQYKSICQAILRMNSTKALACLDYLNENIFTGNQTMKCLEIHQELSELIRNSSTNYLEPVEVRMQNYSGTKHTRKVVESGFDKSIIDFSKILKKIVGLLDEEVQYGCLGTESIDMYPFYEVLFYDYCRPLNQAFASGHQRSVIHSSCMDPEYYVGDEKKIDSEFSNAEKDGKDLISWLPDLSILYKLYSESGALLNLYDWYIAFSEHLQAGKENLKEDDNHPRESPQGNLQRELNELDEDKRKLEEAKLQSRFLFGLEELRFLGLIKPTARKTDHVMKTIYHQ
The following text describes a protein:
Function:
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
SALWALRPHQAHSALHLPRRAAPSEPPIPAIALNLGGARPRSPPCPDLPLSLLEPRRRRRPRVLPQSGSLRLRPSHCRRSIVHHEPGSSSAAARGALPGAWRPRVFFGVIGRPKARSLGDGQGMSIYGETFPDENFKLKHYGIGWVSMANAGPDTNGSQFFITLTKPAWLDGKHVVFGKVLDGMTVVHSIELQATDDHDRPLTDCTIVNSGKIDVKTPFVVEVPDW
The following text describes a protein:
Function:
Confers resistance to heavy metal ions (e.g. cadmium (CdCl(2)) and copper (CuCl(2))) by chelating them at the plasma membrane of root cells, thus stopping their entry and reducing their accumulation.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Secreted, cell wall.
Sequence:
MYNAPSAQEMSYSDHVQRRHEEKGCLYACVFTALCCFCCYETCECCLDCLCCCCS