lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle.
Sequence:
MGEKITEDQVANLLAILRTDGSVDAKVNQINNIKSSIKQHNVPEPCILSLFEALRIALSSQHAALVNAGFSTLNHLLTRLSRQEPKYITKEAARTLPMINDKMGDQREKYRQLAAQCLTTFWKNAPMDVERIVKNAGLVGKNSRMKETSMNWIVQMHQEHGMPFKSFVTTLMELLEDADGMVRDTARNTVITLFHRNAPNGAKSDLKKQLKNFNVRPAIVSAITSQLIQAGPPVVVEQERPEAPMRNPLATSASAMNISRPATPEVRVEQVEPAYVNTQRELEETFQEMQQWFQDKESEANWLKREQSCTKLRRLNAGNAPSDYHDAFLAGIKSLLDGILKAVNSLRTSLSKEGCSLVQEVARTAGPGLDPMVEILLQNLIKLCGGTKKISSQNGNATVDIIISGVTYNHRIMQHIWLACQDKNVQPRTYATGWLKTLLKKEAQHKSHVEHSGGLELIEKCLKKGLADANPGVRENMRSTYWTFAQIWPARAEIIIEDLEPTQKRLLENSADNPNAPKKAAAVSTRPGLGFSKSSTGPPRPSLRETMLAQKKAQMANKNIPSRPGSAMSTFSPTRTVPTKSSSEAAPTRPYLEANASRGGLSVAPMRPSKSKRPELAPRPATAGPYSVRRTNQASSEANASPSSSTTARPPRSKTPVATSSPQARRAPVPRPNTSHTSHPTQSSQPTQSTYTSPAKTVPGKVTTASPRLAASPHISSPVRTRTKSVPGAPLSSPTRADEDFTMVVPTITGLERIQSEKSHQVFDSSNREEIKAPVNQPMKVYEDPFSSTDDTTTPRPTVTASVLEEVPVNEDAMNLSRNSIGELDGEGIKNPPMSPDKLKQTTKLLDSGIAKIRGKTLDVHGFRKLQTMIKDNKAVWGDGRFPALVMGLFEYLEEPLTNLSPAKVQDVKAQILATIKVLYKNYREYFRPHIAKGFHSILVTRSCYDARTHIVSGLELLADELVTLANPKDTISTILRSLSDEEMSLEGCRKLSMGLHILKQTLDVKSEVELDDAEIDSILALAAKCLESKESGVRLDAVVLCVSTHARIGEARFWSGIGGRVSGDPKSLITYYIVKRQRELEMGN
The following text describes a protein:
Function:
Involved in the glucose/cAMP-signaling pathway. Required for maintaining basal cAMP levels and for producing a glucose-triggered cAMP response.
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Septum.
Sequence:
MGFTSVEPPDFFDWTARAIFLLSTLRSRRNAKQIERENALLDQIKELLSIAIIQCHERNIPSIDLPPSFFNYVCEQLPRHPFAKIASSYIDTHTLFFQISISSFLCRFSNCSEDEIRLFKQHQSLDSFLLSLFDLLCSHHFSVEFTSISLIIKSSQWLFYTLSDYAHESLTGVEADITTKFLSTLADTWPEFEEQCTLSKHLFLLGDFSLISYVKVLCGVFNIPNYNAFILSVEDLLPENISFAAVADFQLSKYRAINDNSVLRSDDFSSKAVFDKYVERECYYSENAISKIFQNYPDLAVLFEELQYAEGNNDLLSAILNTNKYTLRPDDCAPYFYRLMDLCLRYCYSQSNEIGTNVLWSMTTSFINIWRIHPGTCCCVVLSIYWPYLEDKLLKFSDLGDIFEYFFSLIHDCDYAIWSVHDEHQFSELLAFYHRRALNDLVEELGSCPRSSDSCRAILDILNNYIFSCPLFLVTPEELEEQYTDFFKKLKEKYGEFFQNLLKKELTGKPESDLEGLRLVGVQLQATYENLKSNFSARIFNQLSVHSFFAEATCHLFLEKLPTITKTYVYSNCKEIPDHILEMINALYQQTRALVACTGYLSSDYPKIYEAFSGTFVYRNLSLIIDKGLANVLQTVLRESFIPKRSRFYSDSTKMILAPLQDCYDFLQKIDWPSSKDANRFYLHLGKLSENYIHYYVDSMYALFIYSTDIPLKAEPLVPDLPVKQLKEKASHFKRHSGDPNFLKLYRESFTLINTVSLVSGWLKMLHQRIDYKILTEKVMHFKDMEVPSATVIISIKMAHLLVTPKAPYSFSVLLQDPESEFCVHTRDVYDELVPNWKETYQMEITNVKRFKLIIYQRNIHTGLETVYGHATLEVDPDKLKQGHGKDVWLDITNKGQILIGLRVLLKRETPNYYCFAQMEYLTVTEVKMLNVLMISLSKFIRNSLRNSGLMDFVRYLDGDENDNAEAETKEKMDELQARCEKEQQSLLAELDDFFYWIYVNLLPKPLFYLLSRLWFGLLETFRDILVPPVTDSTLRRIPLNKRELKMVYSWLQLFYDFFRNFQDIAPFDFLNTDEYKSVMAIKDYYFVKSKDVKRVSS
The following text describes a protein:
Function:
Probably involved in the defense reaction of plants against pathogens.
Sequence:
MKAHLVLFLLMILVTFTSNVNTLSINPKSNSSIPQLTQQKRPDNETIYRVSKQLCWGCIAESLEFLFRHNLVRAAKWELPLMWDFQLEQYARWWAGERKADCKLEHSFPEDGFKLGENIYWGSGSAWTPSDAVRAWADEEKYYTYATNTCVPGQMCGHYTQIVWKSTRRIGCARVVCDDGDVFMTCNYDPVGNYVGERPY
The following text describes a protein:
Function:
Plays a role in olfaction.
Sequence:
MKTGSNNNHISASSSSSNNNNNSSLVQQQQQRSTTSVSVSSSHIVTEWEDGIIFDVDDPDFCNLATDKLNFIVPSAANMSIASVHGPQIADICSPLSHHNLGLSASLPDLVGSPLEISMDNVLTIEELRQHMGSCFTCGVSWTDDHVSLDCSECGGYSLERPCPLCDGQCGVQWKRDFAMSHACSQARWVGVCISYPEVVAGVQLPVGAGAGAATSCAAAAANQLRLAQELCSRLEQLSTSTASKSGRI
The following text describes a protein:
Function:
May act as a scaffold to localize and regulate type I phosphatidylinositol 4-phosphate 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3.
Subcellular Localization:
Cytoplasm. Membrane. Note=Localized to large cytoplasmic vesicular structures.
Sequence:
MATPSLRSHEIPAHSQEAGNKSISSGSRRGLLWHLRARQSRVGLFEVGPGHELHRMTRMMQEGLWAATQVSKNNPPTGPTTQKDYLEVMTQVHEEGFELGTLAGPAFARLRKSIGLTEEDYQATLGPGDPYLQFFSTSKSKASFFLTHDQRFFVKTQRRHEVHVLLAHLPRYVEHLQQYPHSLLARLLGVYSLRVAQGKKKYFIIMQCIFYPTSRISERYDIKGCNISRWVDPAPEGSPLVLVLKDLNFQEKTMRLGAQRSWFLRQMELDTAFLREVNVLDYSLLVAIQFLHEDEKGIHHSVFSTFKSIQGVSKSKGTGDQNCRMLPDLPNALHILDGPDQRYFLGLVDMTTVYGFRKRLEHVWKMVRYPGQSVSTVSPAHYARRLCRWAEVHTE
The following text describes a protein:
Function:
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
Subcellular Localization:
Cytoplasm.
Sequence:
MITVNTLQKMKAAGEKIAMLTAYESSFAALMDDAGVEMLLVGDSLGMAVQGRKSTLPVSLRDMCYHTECVARGAKNAMIVSDLPFGAYQQSKEQAFAAAAELMAAGAHMVKLEGGVWMAETTEFLQMRGIPVCAHIGLTPQSVFAFGGYKVQGRGGKAQALLNDAKAHDDAGAAVVLMECVLAELAKKVTETVSCPTIGIGAGADCDGQVLVMHDMLGIFPGKTAKFVKNFMQGHDSVQAAVRAYVAEVKAKTFPAAEHIFAD
The following text describes a protein:
Function:
Nuclear-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. RRP6 has 3'-5' exonuclease activity which is not modulated upon association with Exo-9 suggesting that the complex inner RNA-binding path is not used to access its active site.
Miscellaneous:
MISCELLANEOUS: Present with 2160 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus. Nucleus.
Sequence:
MTSENPDVLLSRVINVVRAASSLASQDVDFYKNLDRGFSKDLKSKADKLADMANEIILSIDEHHESFELKEEDISDLWNNFGNIMDNLLEMSDHSLDKLNCAINSKSRGSDLQYLGEFSGKNFSPTKRVEKPQLKFKSPIDNSESHPFIPLLKEKPNALKPLSESLRLVDDDENNPSHYPHPYEYEIDHQEYSPEILQIREEIPSKSWDDSVPIWVDTSTELESMLEDLKNTKEIAVDLEHHDYRSYYGIVCLMQISTRERDYLVDTLKLRENLHILNEVFTNPSIVKVFHGAFMDIIWLQRDLGLYVVGLFDTYHASKAIGLPRHSLAYLLENFANFKTSKKYQLADWRIRPLSKPMTAYARADTHFLLNIYDQLRNKLIESNKLAGVLYESRNVAKRRFEYSKYRPLTPSSEVYSPIEKESPWKILMYQYNIPPEREVLVRELYQWRDLIARRDDESPRFVMPNQLLAALVAYTPTDVIGVVSLTNGVTEHVRQNAKLLANLIRDALRNIKNTNEEATPIPSSETKADGILLETISVPQIRDVMERFSVLCNSNISKSRAKPVTNSSILLGKILPREEHDIAYSKDGLPNKVKTEDIRIRAQNFKSALANLEDIIFEIEKPLVVPVKLEEIKTVDPASAPNHSPEIDNLDDLVVLKKKNIQKKQPAKEKGVTEKDAVDYSKIPNILSNKPGQNNRQQKKRRFDPSSSDSNGPRAAKKRRPAAKGKNLSFKR
The following text describes a protein:
Function:
May play a role in hearing.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MEIRCTEEGPGPGIFRAELGDQQQPISQSQRWCCLQRGCVILGALGLLAGAGVGSWLLVLYLWPAASPPVSVTLQEEEVTLSCPGVSSEEKLLPSLPKAVSFRINGEDLLLEVQVRARPDWLLVCHEGWNPALGMHICQSLGYFRLTQHKAVNLSDIKLNRSQEFAQLSARPGSLVEEAWQPSTNCPSGRIVSLKCSECGARPLASRIVGGQAVASGRWPWQASVMLGSRHTCGGSVLAPYWVVTAAHCMYSFRLSRLSSWRVHAGLVSHSAVRQHQGTMVEKIIPHPLYSAQNHDYDVALLQLRTPINFSDTVSAVCLPAKEQHFPQGSQCWVSGWGHTDPSHTHSSDTLQDTMVPLLSTDLCNSSCMYSGALTHRMLCAGYLDGRADACQGDSGGPLVCPSGDTWHLVGVVSWGRGCAEPNRPGVYAKVAEFLDWIHDTVQVR
The following text describes a protein:
Function:
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
Sequence:
MPPELTPTRRSILQATLRLGAGATAGQVAQEVGITKQAISQQVNILRKLGYLQPAETRYGPLQVTDRARAALGEGLPIYGQIAAGIPALAEQSPEDFTPSIEALLGLKAGDFLLRVRGESMTGIGVMDGDYVVVRPAPEVHDGEVAVVLVPGDNAATLKRLYHFGQDILLTSENPAMPRLSFPAEQVQVQGRMVGRVGVGAPRVSHRVTE
The following text describes a protein:
Function:
Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.
Miscellaneous:
MISCELLANEOUS: Present with 450 molecules/cell in log phase SD medium; MISCELLANEOUS: [Isoform Peroxisomal]: Produced by alternative initiation at Met-23 of isoform Mitochondrial.
Subcellular Localization:
[Isoform Mitochondrial]: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side; [Isoform Peroxisomal]: Peroxisome.
Sequence:
MRICHSRTLSNLKDLPITSRRAMHSAIVNYSTQKAQFPVETNNGEHYWAEKPNKFYQNKRPNFQGITFAKQQDLPSLPVPELKSTLDKYLQTIRPFCNDVETFERQQLLCKDFSEHMGPILQDRLKEYANDKRNWMAKFWDEQSYLQYNDPIVPYVSYFYSHMPLPNHLSKIDNDPLIKATAIISTVVKFIEAIKDESLPVEIIKGMPFCMNSFSLMFNTSRLPGKPEDNQDTNIFYSVYENNFVTIAYKGKFYKLMTHDGNDKPLSENEIWRQLYSVVFQGSQSDPKLGGIGSLTSLPRDQWREVHLELMKDPISQDSLETIHKSSFMLCLDLDQSPVTLEEKSRNCWHGDGINRFYDKSLQFLVTGNGSSGFLAEHSKMDGTPTLFLNNYVCQQLNKLDVDDFMRKVITPSSTVAMKPMELPFIITPKIHKAIESAQLQFKETIGEHDLRVWHYNKYGKTFIKRHGMSPDAFIQQVIQLAVFKYLKRQLPTYEAASTRKYFKGRTETGRSVSTASLEFVSKWQNGDVPIAEKIQALKHSAKEHSTYLKNAANGNGVDRHFFGLKNMLKSNDDQIPPLFKDPLFNYSSTWLISTSQLSSEYFDGYGWSQVNDNGFGLAYMLNNEWLHINIVNKPAKSGASVNRLHYYLSQAADEIFDALENENKRKAKL
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MTSSEAIAYTVVASDPSSDVIELSTQDLRNNLQRGSDEVKLETLRHIIVSTLNGSPQPTLLMPIIQYVLPSRNKQLKKMLHFYWEVCPKLDEKGNLKQEMILVCNAIRNDLQHPNEYIRGSTLRFLQKVKEPELLEPLIPTIRQCLEHRHSYVRKNAVFCVYSIYQQNESLIVDAPELMETFLAAEADTTCKRNAFVLLCHTAPERAVQYFLGLGDQAASQDELMQLAIIELIRKHCRGDSPNRARYIRAVSELLSAPSHSVKYEAATTLTTLTQNAAAVKATASTLIELIVKESDNNVKLIVLDRLDALRTKHEHVIDPLVMDLLRVLSSPDMDVRRKALRIALEMVSSRNIEEVVLLLKKELMKTVDSSQSQDKNLEYRQLLIQSVHTCAIKFSEVASNVVHVLMEFLGDSNNPSAVDVIAFVREVVEKFPDLRSSIVDKLLRTFTDIKSGKVFRGALWIVGEYCASIQDVKEAMQQIRKVIGEVPILAAEERLLESSTAETDGTKEEADAASSYSALAAAKPTSSAANRVRADGTYATETAFSSETNQAARLEAVKNASKPPLRSLLLLGDFYTGSVLASTLTKLVLRFAELSSDAGAKNSLRAEAMLIMTSIVRVGQSNFAASPIDEDSTERIMACVETLASSAEEAQPESKEAKQVFLHDTKQAYTKMVEHEQAKAAEKLAKETKKVKVQPDDLLSFRQFSKQAADDAVEEYERELTQATGTAEAAKDDFISKLARVVQLTGFSDPVYAEAYVNVHQFDILLDVLVVNQTSETLQNLSIEFATLGDLKLVERPSNYTLAPYSYQSIKATIKVSSTETGVIFGNIIYEGAAGTGTQSAGDAKCVVLNDIHIDIMDYIAPAYCNEAQFRAMWTEFEWENKVNVNTSITDLRDYLAHIMKSTNMSCLTPEASLAGECGFLSANMYARSLFGEDALANLSIELLPDGKTIQGHVRIRSKTQGIALSLGDKITLAQKAASKD
The following text describes a protein:
Function:
Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MAPAGKQKSIVFFHPDLGIGGAERLVIDAAVGLQNRGHKIVIFTSHCDPKHCFDEARDGTLDVRVRGNWLVPSSILSRFSIICAILRQLHLIVWAYFTSEISDLKPDAFFVDQLSAGLPWLRFFYPNTRIFFYCHFPDLLLAQGRTHWLKRAYRIPFDFLEQWSMSYAESIAVNSGFTKSMVEQVFPDLAREKDLQIVHPCVDVNPKKTETKDDAVPVWQDRIILLSINRFEKKKDIGLAIKAYAGLGKHGRQGVRLVLAGGYDNRVMENVVYHKELDKLATGLGLKTATTKTIVTALNVPDDVDVLFLLSVPNTLKEMLLNSARLLIYTPSNEHFGIVPLEAMLAGVPVLAANTGGPLETVVEGKTGWLCPPDDVERWTAVMDKVLYKMTDEQVKKMGVAGTERVKNEFSDVKMAEKIDGLIDGMANVPRKSALQLSSFLMTIGIVLLDITYWCAGQNESNLAIGIYVQDEKGVF
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MLFEAAGEGTIVEGSRICGQDADPLSLPLVEDGAIEEEQAAPIQTIHRTVFAVPRVPSPSPVSTSGANLNLKTENAATATPQRKISTSSRFMNAFSQLYGGGNSGPSCGHVEQHNEEPGDLSANRTPTKGMESKLVAMWHNVKYGWSGKMRQTSFSKEQPVWLLGRCYHRRFTPPVSMESSITELPSGADTTPDNATSAFDSIQATSTSTSLYPALNPQQIDEIVVPQELGMDAVENQVGEQPWEEGIEGFRRDFYSRIWMTYRREFPIMNGSNYTSDCGWGCMLRSGQMLFAQGLICHFLGRSWRYDSESQLHSTYEDNMHKKIVKWFGDSSSKSSPFSIHALVRLGEHLGKKPGDWYGPASVSYLLKHALEHAAQENADFDNISVYVAKDCTIYLQDIEDQCSIPEPAPKPHVPWQQAKRPQAETTKTEQQQHWKSLIVLIPLRLGSDKLNPVYAHCLKLLLSTEHCLGILGGKPKHSLYFVGFQEDRLIHLDPHYCQEMVDVNQENFSLHSFHCKSPRKLKASKMDPSCCIGFYCATKSDFDNFMESVQLYLHPMRCASGATVDKAAGSHHTTPQSSHQTEQTEMNYPLFSFSRGRCMDHERDEMSDSLYKPLIKQVASLAQELGAQLAPPQHGDEHDQDDSESEEFVLL
The following text describes a protein:
Function:
Probable transcriptional regulator.
Subcellular Localization:
Nucleus.
Sequence:
MYSPSSPQSSEPMSPESDYGGGNSINNSNSSNNSSANQSPQFSVGKMKVDSEEKVKKRQVRLLKNRQSAALSRSRKKEYIANLESKAQELTHSTQELHVQYNKISSTTFETKSRLEFLEKSLRSLRMENEFLRTKFEDINNNNIKSHSRSNSSSSSLSSSPTTPNTTTTTTTSTTPVQLIINNHKSESSPLLLNSTNSSPTIASTLINTKDIINVSQNKNNNNNNNNNNNNNNNNNNNNNNNNNTTNLLDQQQQSPTPVLESLIKKDREREILIGINKINHFKFNNNNINNINNINNNNNNINNIVNDEEDEEKCKINSVEESNSNHLNNNFSNLSFSSPNVNSQPIYLTRVRSSSYHPSNYLGMESPTINAGHHMIIPTESLILSSNHHHHHHNNINNNSNNHYHHESSTASSSSGGNKLPSLYSITNNLGGGNSSSPSSSSTSSPSTSSPSTPKSMGFPSPIFIGSSGSGPSSSGSQINHRSSIIGLSKLKSYNNNNNSNNNNSPILYPISTNQYPSLINNNNNNNNY
The following text describes a protein:
Function:
Actin-binding adapter protein. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G-actin. Controls pseudopodium number and motility in early stages of chemotactic aggregation.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell projection, pseudopodium.
Domain:
The SH3 domain mediates the control of pseudopodium number.
Sequence:
MASLDISDPDITKYIKLVQDGNPANRWIVFSYVPKSNNKIKFCDSGSGDLKELREELDDSSIRFAYIRFVINNMPKFVYIPWCGDGVNGPIKGAFSGHAIEFSKSFKPIHHQVNARSEEDIDEKAITAALNKATGASYDSGSKVQGATKGTFIPQSVSQGREAATKSNAEVKNVINKNDYNKIQESAEYWKQNQANKSEPAKPTRPEYNLSTERDDYWKQQQAEKQKQQQQQQQQQASRVNAPPPSRTVGNKFQEQVSKPTETAPPQPRPAPSKGSVLNRFPAATQQQQEPPAPSRPAAPVPSRVNKPAAPVQPVYQEPVHEEPQYEEPQYEEEQQQQYEEQPTEEQQYYQEEPQQQYEEQPTEEQQYYQEEQQQYEEQPTEEQQYYQEEQQQYEQPTEDQQYYQEEQQQYEQPAEEQYDQSGYLQAKALYDYNGENDGDLSFREGDIITILDQSDPDGWWQGSLPTGEQGFFPSNFVQQL
The following text describes a protein:
Function:
Part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSGPAIDASPALTFNQSSASIQQRRLSTGRQMWVLYRRFAAPSLLNGEVLTTVGAPIIFMVGFYIPFAIPWNQFVGGASSGVASNLGQYITPLVTLQAVSFAAIGSGFRAATDSLLGVNRRFQSMPMAPLTPLLARVWVAVDRCFTGLVISLVCGYVIGFRFHRGALYIVGFCLLVIAIGAVLSFAADLVGTVTRNPDAMLPLLSLPILIFGLLSIGLMPLKLFPHWIHPFVRNQPISQFVAALRALAGDTTKTASQVSWPVMAPTLTWLFAFVVILALSSTIVLARRP
The following text describes a protein:
Function:
Component of the cytokinin signaling pathway involved in cotyledons, leaves, and embryos development. Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Relocalization from the cytoplasm into the nucleus is induced by cytokinins.
Sequence:
MKSRVRKSKYTVHRKITSTPFDGFPKIVKIIVTDPCATDSSSDEENDNKSVAPRVKRYVDEIRFCDEDDEPKPARKAKKKSPAAAAENGGDLVKSVVKYRGVRQRPWGKFAAEIRDPSSRTRLWLGTFATAEEAAIGYDRAAIRIKGHNAQTNFLTPPPSPTTEVLPETPVIDLETVSGCDSARESQISLCSPTSVLRFSHNDETEYRTEPTEEQNPFFLPDLFRSGDYFWDSEITPDPLFLDEFHQSLLPNINNNNTVCDKDTNLSDSFPLGVIGDFSSWDVDEFFQDHLLDK
The following text describes a protein:
Function:
Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK. Mediates the deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation. Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytosol. Golgi apparatus.
Sequence:
MKGEEPVGNLSRFCCIPPGYTGKTKKGHLIFDACFESGNLGRVDYITEFEYDLFIRPDTCNPRFRVWFNFTVENTAPYQRVIFNIVNFSKTKSLYREGMTPLVKSTSRPRWQRIPAKNCFYYRCPDHRKNYVLSFAFAFDNDTDVYQFAYCFPYTYSRLQGYLDDIERRSLSYFKREMLCLTVQQRRLDLLTITSPDNMNSPLRKRVVFITARIHPGETPSSYVCQGLIDFIISNHPVAKVLREYLVFKVIPMLNPDGVVLGNYRCSLMGFDLNRHWHEPSPWAHPTLVASKNLLMELDSDSTAHLDFYIDIHAHSTLMNGFMYGNIYDEEERYERQAVFPKLLCANADDFSMSNTSFNRDAMKAGTGRRFLGSSLDPETHCYTLEVSFFSYNTNSTTSPYTEDGYYKLGRNVARTFLDYYKLNSLVVKSKNNQKSSTRRESSGASSRSNGQSTIDPNTLPYPMKFS
The following text describes a protein:
Function:
Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MAAPTRQACGGGGGRLFLFILRRLPAPPSPASRSYKVRPVPNWPRRPRFPDPEDPLTPTWQLTPQYAAKQYGRFGAASGLDPARLWPGPERLRELEAEEREWYPSLRDMQEALREKERLREEKRLARENLIKANMAKMPQMIADWRREKKERWEKAQADKLRRGRLLAEAREQLGYNVDPRSTKFQELVRDLEKKQRKQLKEQKQQQKLEARAAALQAAAAASPE
The following text describes a protein:
Function:
Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.
Sequence:
MAECLEDLKVRREKIVLEYWQLHQFLEEQERHFLAQLDELEKEMQKEQEEVVSQLDGTFSLLSSIISDLEKDCQRPDAEFLQNLKETYTRGEKAILKTVKSPPNMKQAINTISQKSIALRENIRKFKESLAVELKRERTSCQNDLPEEQPDHLQVLRTCEDAQKTSTEESVTLDPHTANTRLLLSPDGKTARHWGYPQALPNNPERFDLEPFVLGCVGFYTGRHSWTVAIEHGQSWAVGVARASVKRKGPLCLSPEQGVWAVEQCWGQFRALTSQWTPLPLAKVPRMIQVCLDCEEAG
The following text describes a protein:
Function:
May play a role in defense responses.
Subcellular Localization:
Nucleus.
Sequence:
MVELCGGEGEGQIMLATELAQLRAMARELEAKMDPDRVAARELCRALASSVDRSIRLAASCFPPPEHPPPAAGNAGRDAAFKKRKGMAKVRRQVRVTSVQDTASLDDGLSWRKYGQKDILGAKYPRAYFRCTHRHTQGCNATKQVQRADGDPLLFDVVYLGDHTCGQAAVAAAAQSAPPEHAGQEQQRQSSLLAAGTEGIHQQVVAEPMAAPFLFTSTAAGGVDDGYFSFISPANSDCQFSSDFSAGSVGVDMDHEARFEDLFSSTLEFFQSEIQNL
The following text describes a protein:
Function:
Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.
Subcellular Localization:
Nucleus.
Sequence:
MEDDQQFCLRWNNHQSTLVAVFDTLLENGTLVDCTLAAEGKCLNAHKVVLSACSPFFESLLSRHYDKHPILILKDVKFQELKAMMDYMYRGEVNISQDQLGALLKAAESLQIKGLSDNRKGGETDRKPAAPPPAPSKSPQPTSLPKVQGLTIEQRNRDDSREGSQSPGPRKKKRIRRKSEELDNHHDASNSSESHSNQTPAQNIPTMLPASKLIADVPEPVETKSEILTRHKQSDDVPQVPIIKEKIETHTELMLEPKSEYVEEMNEDSIEDLTLDDDDISNMESMDDGAGPSHGNAGEGSSQGFGGWHMGNQSQDEVFLAAQEAVGAHRDSQGLIEDPSLLTNSLDFQETLVEEIPSWTIHVIYPEDRTNEPLLPDTDALISVAETVVDESPKPPEPPPEPVEKAKKPTRDTLPFADCWTPKGYICPNCQKVYNARKNLARHVNSECGKEPQYSCPYCEYKNYRRNEIKKHAKNKHHLLFT
The following text describes a protein:
Function:
Peroxidase capable of degrading beta-carotene.
Sequence:
MRLTYLPLFAGIAIQSASALPDFFKSSVLKPRRTNSLLINPDAQPDLPTAQQASTAAASVGLNLTDIQGDILIGMKKNKEMFFFFSIADATAFKSHLDSAILPLITSTQQLLTVATQPTTAVNLAFSQTGLNALGLASQGLGDSLFASGQFSGAESLGDPGTSNWVQAFAGTGIHGVFLLASDTIDNVNAELSQIQSILGTSITEAYRLQGEARPDDQQGHEHFGFMDGISNPAIDGFSTALPGQAVLSPGLFLLAEDGDGSSSSRPSWAKDGSLLAFRQLQQRVPEFNKFLADNAALTQGNADLLGARMMGRWKSGAPVDLAPTADDVDLANDPQRNNNFNFTHPDFTETTDQTHCPFSAHIRKTNPRSDFNPLNTANHIIRAGIPYGPEVTDAEASSNTSSTDASLERGLAFVAYQSNIGNGFAFIQQNWVDNANFFFGKTTPPGIDPIIGSNAAQNNFAPNSPRPVSGLDPTDSTTIVTLNTDFVVSRGGEYFFSPSLSAIQNTLSV
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as a non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells; Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MATGVRIAMFLFLAFSSAVAQNVTESKVQEFHVGVVLDLGTTVGKVAHTSISIAVEDFYAIHPNYTTRLVLHVRDSMSDDVQAASAVLDLLENYNVQAIIGPQKSSQAVFVSALGNKHQLPIISFTATSTSLSSPGLPYFVQATSRDSAQVSSIASIIKTYGWREVVPIYVNNNYGRGIIPDLANVLEGIDAHIPYRSAIDESATGEQITQELYKLMTMHTRVFVVHMSSSLGSLLFTKAKEIGMMSKGFVWIITDGLASLVDSLNHSVVEAMNGALGVVSYVPKSTELDNFTMRWYMRSRNDHPNDPTLKLSIFGLWSYDTIWAVAQAAEKAKVTEDKFERPPAIENYTSSKTLENSRNGPAVLKEILQTKFQGLSGYFDLTDGQLQISMFQIINVVGKAHRVIGFWTAQNGISQQSDQRRSNTTYWSTTPTRNLKTVIWPGESTEVPRGWEIPTDGKKLQVGIVIGAGYPKYIDANEDSLTGEIKASGLAIEIFEEAVKRLPYALPYEYVVFNTTENKYDIAVGDITIRYNRSLYVDFTLPYTESGVAMVVPVKESVDKNAWIFLKPLTPGMWFGTIILFIYTGIVIWLLELLGNNKNVQEEMVKRLTSRIVLVIWLFFLVVLKSSYTASLTSMLTVQQLQPTVTNVDELLKTGQSVGYARGSYIKGLLEELGFDASKIKPYDTPEGYHNVLSKGSKNGGIAALVDEIPYIKLFLAEHCMGYTMVGPIYKTAGFGYALRKGSPLVGDISQAILNITGGDTIIQIEKKWIGDQNNCQNVGTISGTGSLTFDNFAGPIIATGVASTTSLVVALIVYFCKKKQVGPQNGGSEQILPPENGGDEESQCQQAARDRGMHGQVNKVMRNGSPVICRGEGIHRSWVSSSARF
The following text describes a protein:
Function:
Transcriptional repressor of multidrug resistance genes, such as PDR5. Required for growth on non-fermentable carbon sources like lactate or glycerol.
Subcellular Localization:
Nucleus.
Sequence:
MASPGSTALPHKRQRVRKACVPCRERKRKCNGKSPCEMCVAYGYVCHYIDGRVPSASPQVQQVGETSPDTESRPFVLPGIHRNEQPQPINTQNVTSQNIVDPTKSRYTIQHSAVAFPRCLGLELRSTNPPRLHSFAWHCGIRPEENPNSHVLLSDLVTKEEYYRISKVYFSVVHPIFDVVNPEQLAKNVEKYWDGDVKTLEYGAVIAGVIALGSFFMGSLGHPREMDIVQYAKGILDDPTFSRIPTVEQVSAWVLRTIYLRATSRPHVAWLASCVTIHLSEAIGLHHEIDREDIAISNNVPPKRTTVVSEHTRRLFWCAWSINTILSYDYGRSSVTLNRITCKPVKETDGNFTAHLVALAHLIPQDSVNANAAQLLQALAAVHESPNAHPFLSLTKGDICLSLYRRLRLLNHILDKNVVLQIIDIGNTALSAAYALVKLDQAWWNVLSTSFQYVCVLLAIDTPESLSHVATAMKTLDNITQILGTRIAFEAQKTAKLLLEDSMKKKRQEIQQLEQATHQRSNLETTHLLDIDWDALLDPSDTLNFM
The following text describes a protein:
Function:
Subunit epsilon, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). May be essential for the assembly of F(1) and may play an important role in the incorporation of the hydrophobic subunit c into the F(1)-c oligomer rotor of the mitochondrial ATP synthase complex (By similarity).
Subcellular Localization:
Mitochondrion. Mitochondrion inner membrane.
Sequence:
MVAYWRQAGLSYIRFSQICAKAVRDALKTEFKANAEKTSGSSIKIVKVSKKE