lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.
Sequence:
MSDIPPTNESNSDSTLINQKNNDNNDNKETGKDISSTHTHHRVTFAEQQPISTSSRKSSLLRKHSSNNTSSDSDKRPSIISRNSNPDIHRDSLPPLNRGPSYNGNYTRSHSSRNVNANNTINTGVTSDSNSNNNVDSNAPISSPTTPAISSPPANGKYFNLVLPAGKSREKSPGRHSKEGHTRSRSFTKQQHGIGSTSSQSSSQYLAQEKAYLRKMRNQSVDDYYSKGIPGAHEVSKADDNDDEDDDDEEHSSFDGGDNANLLAAIDDDKYQIDYSMALSLMKNSNVNLRKIANLNTDDTDDPAIIERLEWQSMLTSVLTGDVVRSEKTKIININNPDSTQESYLHATFKENLWFGIRAKIFNRTEDEQRKIVAYRRTLVDQLIDDVMKFEIDYENSTDNPIRDQVKTILDRYDQACSLWKTLEDMYSDKPACRSEEFQNRIDALTAWLTITDAISRETKSLRLWIGNDELDITKSPVEVSSSNAATSTSKIVKKIFDEDNKSLAERLMKEKDVQTIFRKRIFKPIAPWMIKSKDTYIRLGVIFENMKLPDYLHDLLQICIIPVRLIKEIVIVRLGYAMKLQNPTLMMIDQMLDDFKSYITVALEVKSGISEYKEPDEDRKWLISDLFDSELEDFDNVILRCVRYFLVLLNRKLLDSSRSPTTFRTFKEPEELEEAWNFLKPLGHYVDGGSVVVAEEITMLASRLIHRLMAYFNHQIREPTYNGVPQDLIRWYSSTSENFGQLRRKLARFMGEISRDFKNSVVFDIPSQSNCTKTLLEILRSSNHFLVYTGTVETQGTYFFASPELLGNEQEILKILTGSCVGLDPSTDNSHFTDLLHLIRSGSEEHLRYNDDDLDSYDDSNGAYAYVLALCPMKPIVWDGLVVNVDIDSVPITDMKNGELLLVSKLSYYDLHIVRNRFLEVASEVSLGNAGLKQVEYRCSLAKVNQELKKMNRVVFKMCSSVLESVQVIKTRIAELDPVGEYQALINSYFIYARDYGKNSVRTLDPQRKSTIIMKMIQLSIDWVSFICDDCIPTDRKTFRWCVLALEFSMEMIRGINIFLLTEEQFTKLKVKVARCMSLLISHFDIMGARSSEAEKNKLLKWTAQRHNIASSQNDDEYLNKVYHEEVMGQINKIEERRRNLQEEFQSIGRVLDVSDSEYQFLTLLASSFSSVSIRWQKGACIGRGTFGQVFSAVNLDTGGVMAVKEITFHDSQSVKTIVPSIKEEMTVLEMLNHPNVVQYFGVEVHRDKVYIFMEFCEGGSLAGLLTHGRIEDEMVIQVYALQMLEGLAYLHQSGVVHRDIKPENVLLDHNGVIKYVDFGAAKVIASNGRTIGGMTNSSLRKSVKRDGHNNLNSMTGTPMYMSPEAITGTSTDRSGVVDIWSLGCCVLEMATGRRPWANLDNEWAIMYHIAAGHKPQLPSPEQLSEPGRTFLARCLEHDPTKRPSAVELLADPWMVEIRHMAFGNSDVTTTPLSEVAGPVSE
The following text describes a protein:
Function:
Transcription factor that binds preferentially to the octamer motif (5'-ATGTTAAT-3'). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAGRRSSNVFPLSGNSGGGLEVDTPTWLSSQAATSRLMVRPSMGPGICPGPEVWGVPLGSSPYEFRGGIAPYRACEARAWSQSSSEDTCPGPYIALRYMPNLALPEDVSAIQKEMEQLAKELRQKRMTLGYSQADVGFAVGAMFGKVLSQTTICRFEAQQLSLANMWKLRPLLKMWLEEVDEKNLLGICRMEMILEQARKRRRASRERRIGSNLEKLFLQCPEPTPQQISYIAGRLRLQKDLVQVWFSNRSQMGSWPTNDTSRREDVGATGSPFPGPPVCFPMAPGLHFDFTHYEGSCLTPLYSSTPFPVRGALLSAPTTTLGLPRLSS
The following text describes a protein:
Function:
Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little to no effect on actively-growing cells. PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity; Stimulates growth of stationary phase M.bovis (a slow-growing Mycobacterium), reduces the lag phase of diluted fast-growers M.smegmatis and Micrococcus luteus. Sequential gene disruption indicates RpfB and RpfE are higher than RpfD and RpfC in functional hierarchy.
Sequence:
MKNARTTLIAAAIAGTLVTTSPAGIANADDAGLDPNAAAGPDAVGFDPNLPPAPDAAPVDTPPAPEDAGFDPNLPPPLAPDFLSPPAEEAPPVPVAYSVNWDAIAQCESGGNWSINTGNGYYGGLRFTAGTWRANGGSGSAANASREEQIRVAENVLRSQGIRAWPVCGRRG
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MMPQLMTCIRALQQGNSNVTNMLSKLVKEYLEDNSKPVVIDRNFVIDALPSGKINDLRKNIKLVMGVGFAKECYEVYCNWRRESLKECLINLLGLPEINVEEKSRLLEFENYILRRRIEAIQVALGTLIPSERRLCDSVFQGFSYVADLCFTDICRGTSIQLLNIAVVFARASPSYWRWFEIIGMFEAWRDEIPEFQSLFPESVVKKAMAIHDELGEASRDIFMKVINMIFHNPEAKIMVRAMDGKIKIDRIMKRLERKLVAESKHLGERRYFFMMNSWRLVELCAEKSGLDVDCFKKYTAKIQQNLKLYQRSSWNVVLDLLKLENDDRFVEPNANAESMKDKLKLFNNHFKDLCSIQSRWAAFDMQLREQIIMSLENILLPAYGNFIGRFQNILGKHSYEYIKYGMFDIQDQINHLFLETKPMSQRLLKFVSQVCSSKNTYV
The following text describes a protein:
Function:
Probably a connector protein for RcsB/C regulation of biofilm formation, providing additional signal input into the two-component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component.
Sequence:
MHQNSVTLDSAGAITRYFAKANLHTQQETLGEIVTEILKDGRNLSRKSLCAKLLCRLEHATGEEEQKHYNALIGLLFE
The following text describes a protein:
Function:
Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.
Sequence:
MYTFVVRDENSSVYAEVSRLLLATGHWKRLRRDNPRFNLMLGERNRLPFGRLGHEPGLMQLVNYYRGADKLCRKASLVKLIKTSPDLAESCTWFPESYVIYPTNLKTPVAPAQNGIHPPIHNSRTDEREFFLASYNRKKEDGEGNVWIAKSSAGAKGEGILISSEATELLDFIDNQGQVHVIQKYLEHPLLLEPGHRKFDIRSWVLVDHQYNIYLYKEGVLRTASEPYHVDNFQDKTCHLTNHCIQKEYSKNYGKYEEGNEMFFEEFNQYLISALNITLESSILLQIKHIIRSCLMSVEPAISTRYLPYQSFQLFGFDFMVDETLKVWLIEVNGAPACAHITFSPSLGYGFHQHVHMQQISPSVKKEPSLEASSCSGDSFFLLLSQTNFWKAVSTQAVFSSCILICTAVHSGLYTIPPP
The following text describes a protein:
Function:
Receptor for the siderophore ferripyoverdine.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MPAPHGLSPLSKAFLMRRAFQRRILPHSLAMALSLPLAGYVQAQEVEFDIPPQALGSALQEFGRQADIQVLYRPEEVRNKRSSAIKGKLEPNQAITELLRGTGASVDFQGNAITISVAEAADSSVDLGATMITSNQLGTITEDSGSYTPGTIATATRLVLTPRETPQSITVVTRQNMDDFGLNNIDDVMRHTPGITVSAYDTDRNNYYARGFSINNFQYDGIPSTARNVGYSAGNTLSDMAIYDRVEVLKGATGLLTGAGSLGATINLIRKKPTHEFKGHVELGAGSWDNYRSELDVSGPLTESGNVRGRAVAAYQDKHSFMDHYERKTSVYYGILEFDLNPDTMLTVGADYQDNDPKGSGWSGSFPLFDSQGNRNDVSRSFNNGAKWSSWEQYTRTVFANLEHNFANGWVGKVQLDHKINGYHAPLGAIMGDWPAPDNSAKIVAQKYTGETKSNSLDIYLTGPFQFLGREHELVVGTSASFSHWEGKSYWNLRNYDNTTDDFINWDGDIGKPDWGTPSQYIDDKTRQLGSYMTARFNVTDDLNLFLGGRVVDYRVTGLNPTIRESGRFIPYVGAVYDLNDTYSVYASYTDIFMPQDSWYRDSSNKLLEPDEGQNYEIGIKGEYLDGRLNTSLAYFEIHEENRAEEDALYNSKPTNPAITYAYKGIKAKTKGYEAEISGELAPGWQVQAGYTHKIIRDDSGKKVSTWEPQDQLSLYTSYKFKGALDKLTVGGGARWQGKSWQMVYNNPRSRWEKFSQEDYWLVDLMARYQITDKLSASVNVNNVFDKTYYTNIGFYTSASYGDPRNLMFSTRWDF
The following text describes a protein:
Function:
Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway. Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G-siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end. Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs. Association with 26G-siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guanine residue at the 5'-end). May be involved in passenger strand cleavage of target 26G-siRNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MSYNNGGGGGGGGYRNDRDDRYHNNDRQNYRSSDQGRSGYNDDRRDNRYDDRRGSNNDRGCYDQHDRRGSSNDDRRGYRGYNQGGGGYQQQYSQDARYGSNQRNDNYGNNRGSHGGANMYSQNGGNRGGGGGRVGGGRTAAGMSNPGDLVGGADQPIHSVSKKSLRHNAQEFAVRPKTMVQDKGLGQKTTLLTNHTLVQLPQEPITLHVFNIEVFINGKSSNKRELCGPRFWEILKENKPTFGMPNQYIFNDVNMMWSTNKLRQSEGRTNNRRMNFVWKYVKQIKFGGNIEDEETMQLLSTLIDAIATQRARLPLAPPKYTVFKRLTYLICEEAYEPELPDVSLCHKLRIGTDARVGVSIAIRTNLRAGITACFDLGHTLFTRPAYPLVRLLCDIIEHSVVLDEAFEMKYDAALRACNVSDENLRVMTQILTKMTLQLSTETGDYVGEDGEVIVRPAPTIRNPGRNFKFVGLGAPADRYYFTSDGVELTVADYYLQKYNIRLRYPNLPCVLKKAPEQCGNKHSAMPLELVSYIVVPTRYGGFTMPDMRADMINKTTYTAQQRGKLLQHIIAQKSLSGIEPPVSNNDDYMKKHKLVMKREPIRVKATILPPPTLVYGDSVFHDEHHIGEWEAVTHDPPRQVLDGAVFRRKLYKSSEQPLMKRLMGSILLIQSPRQCRDFDYNQQGYHAIMRAIEDSGQPVLWADENKHSAVIQGELQFNQNQHGIEVIEQFLQNIKSTIGEYERDGEVIVPIVFAVFQARATVYSGNNNEYNDYNVLKYLADNKYGIHTQGILEKSLGVVGPSPKNCALTRLMVEKVLGKVGTTHRKLERGGAHKTWTIFTDPAKPTLVLGIDVSHPSTRDRETGNVLQKMSAATVVGNIDLDVTEFRASSRIQDTGVECLIDFSKEIDERIGEFIDHTGKRPAHIVVYRDGLSEGDFQKYLFEERVCIEERCLKIDTSFQPSITYIVVTKRHHTQFFLEDPSQGYESQGYNVLPGTLIEDAVTTNKYYDFFLSTQIGNEGCFRPTHYYVLHDTWTGKPDSFWPTVTHALTYNFCRSTTTVALPAPVLYAHLAAKRAKETLDGINTYKSVNNIYCDLESFGDLCEVNKDMNVNEKLEGMTFV
The following text describes a protein:
Function:
Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MNPDTYAVCEKLIPATYVQQGRESRRVRENKVKHLLEQRKWPEDGWDEETIEMLLRELSVMESNNFQGNCGVGEREGRVASDAVRRRHYGLAHGIGRSGDITAIQPKAAGSSILSKLTNSMALDVLRMTGVRSAASCFVVPMATGMSLVLCFLTLRQQRPKARFILWPRIDQKSCFKAIVTAGFESVVIENKLEGDELRTDIEAVSAKIDELGADDILAVFSTTSCFAPRVPERLEELAKICQEKDIPHVINNAYGVQSSKCMHLIQEASRIGRVDAFVQSTDKNFMVPVGGSIIAGFDREFMDRIGQTYPGRASASPSIDLFITLLSLGSKGYKNLLKERKELFKFLGEELAKVAEKHGERLLHTPHNPISMAMTVNKPDGDGKALTELGSMLFTRCVSGARVVPQGVSKEINGHPFQGFGSHSNNYPSAYLTAAAAIGMTREDVELFIKRLDKTLSKWKGKKDVTTDQVADESKDAVDEKV
The following text describes a protein:
Function:
Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces.
Miscellaneous:
MISCELLANEOUS: The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.
Subcellular Localization:
Fimbrium.
Sequence:
MQIIFGEKCVSLLRLFFAAVLMLWCAQTAAYSGQCHTTQGNPYIGVNFGVKTLEEEANTAGVVKDKFYQWNESNDYYVSCDCDKDNVRSGRWAFAADSPLVYLGDNWYKINDYLAAKVLLQVKGSSPTAVPFENVGTGGDTRWHICDPGGQRLGGQGASGNSGSFSLKILQPFVGSVVIPPMALARLYECYNIPAGDSCTTTGTPVLVYYLSGTINSLGSCSVNAGETIEVDLGDVFAANFRVVGHKPLGARTAELAIPVRCNTGNAGLVNVNLSLTATTDPSYPQAIKTSRPGVGVVVTDSQNNIISPAGGTLPLSIPDDADSIARMNVYPVSTTGVPPETGRFEATATVRINFD
The following text describes a protein:
Function:
May be involved in extracellular digestion.
Subcellular Localization:
Secreted.
Sequence:
MNKALIALFTTVLLATTSYLSQEDPMRTLYSEWKQQYQARFASQFEDEYRFEIFKQNYNYYQEENSRQSSYKLGLNQFATLTDEEFESIYLGGLDDSHVQIDETIKSYNYPESIDWSTKLNPIKNQGQCGSCWSFSAVGAFEAYFIFTNGSNFSYSEQHLVDCDKYSYGCNGGFAGNAIDYLNRNGAILEKNYPYAMKDQDCQKATGDTKAKGRKTWTTAEQAYEAIAQYPISVSVHASNWKGYTEGVFNNCINTSTNHAVVAVGYDKKGNWLIRNSWGTGWGLQGHIWLESGNTCGVLRRLDQVI
The following text describes a protein:
Function:
Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).
Sequence:
MRLQAIRPLRSLLMSNAAASRSMHTTGARGFASALADKHLEGERITKVAELSNEQAVRVTFEDGATAKFHKLWLRDHCRCEHCMHPETLQRQLDTASIPMDTPFHRLQVTDAGGAVAIDWDAPVRGTPCTVSEFDAQWLRDHAYSLEGGNAEDAATSPYPKSYRQPRSTTKELWAGTDFKLPVHDYKTCVDNIEPFMRDLYSYGLVRVSNTPNTMEATEKFSKKIGFVLRTIYGTMWTTNPTNETEGYNDTASTNLELLHHTDGTYMRDPPGLQIFNCAAQAGEGGESRYVDSFHVVETLRSEDPEAFRVLSTTPLPYFTVDNDAHQATMEPLIRVDYANNVVQFRHNDYDRAPLTHLSFEEVGGFYKAHRKLLEVMRRPEMEFCTKLQVGDMVVVDNQRVMHGRHAFQGGDRALIGCYIGQTEYESRLRVLGII
The following text describes a protein:
Function:
Phosphoenolpyruvate/phosphate translocator that transports phosphoenolpyruvate (PEP), 2-phosphoglycerate and 3-phosphoglycerate.
Subcellular Localization:
Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MFALTFLNPNPRLPSPLFLAKSTPESALSRRSRAFSSSNSYPWRPNLRFNGFKLKSATVPENVEGGDLESGSLVKGLKLGGMFGVWYLLNIYYNIFNKQVLRVYPYPATVTAFQLGCGTLMIAIMWLLKLHPRPKFSPSQFTVIVQLAVAHTLGNLLTNVSLGRVNVSFTHTIKAMEPFFTVLLSVLLLGEWPSLWIVCSLLPIVAGVSLASFTEASFNWIGFCSAMASNVTNQSRNVLSKKFMVGKDALDNINLFSIITIISFILLVPLAILIDGFKVTPSHLQVATSQGLSVKEFCIMSLLAGVCLHSYQQVSYMILEMVSPVTHSVGNCVKRVVVITSSILFFKTPVSPLNSIGTATALAGVYLYSRAKRVQVKPNPKMS
The following text describes a protein:
Function:
May be involved in DNA replication and thus regulate cell proliferation.
Sequence:
MEEGEEGTPSGVRCGGGGDGGEGKKEDMFQQLIFMGFSPQLASISLSATSSKSIQHATDWILSNHHGPQSPQEAALEANVSVASTSVSGTVQQHKTLTGYFPSLSPKPPLLHQNPTSHESTLQTAKRQKTVSQSCISEPLSERMRPRGVDEVVGQDHLLGPNSILRSALSRDLLPSLVLWGPPGTGKTSIARAIAGSSTSSYRFVSLSAVTSGVKDVRAVVDNAVKQRKQWKRRTVLFIDEVHRFNRAQLDSFLPAIEDGSIVFIGATTENPSFHLTTPLLSRCRVLALHPLQQSHIAVILRRAMFDKERGLAASIRPAITFKIDEEAIDFLSLHCDGDARVALNGLEVAALLSATERGAESEVTINTDDMKESLQRKHLAYDRAGDEHYNLISALHKSMRGSDPDASIYWLARMLEGGEQPLYIARRLVRFASEDVGLADPFAMTHAVACYQACHFLGMPECDVNLAQCVAYLALAPKSIAAYSAINDAKKMVRASGGGNEGVPLHLRNAPTSLMKDFGYGRDYVYPPNHPNSPRQNFLPPSLLGHKFLHWP
The following text describes a protein:
Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Sequence:
MDGQGRTVDFRNTVIIMPSNLGAWHLLAGMVSKNSMEVARDLVMQEVDGYFHNEEETQYKKIIWEEMNKEYLEEQAAKEALAAELAARGIDPEAGKKKRKRNEDMKSSTPAETPAEATCNMLKRKGLGSKINVGAVDEFGVRPFGVSLLIAGYDDNGPQLYQVDPSGSYFSWKASAMGKNVSNAKTFLEKRYTEDMELDDAIHTAILTLKEGYEGQISSNNIEIGIIRADREFKVLSPSEIKDFMEEVE
The following text describes a protein:
Function:
Mechanosensitive cation channel involved in lysosomal morphology and sensitivity to food texture and humidity. Acts as a regulator of lysosomal morphology by mediating lysosomal mechanosensitivity. Mechanosensitive cation channel in multidendritic neurons (md-L) in the tongue required to discriminate particle sizes in food: acts by promoting activation of md-L neurons in response to mechanical stimuli. Also acts as a sensor of humidity change in olfactory sensory neurons.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein.
Sequence:
MVMSENSNISYCQAVANRTSFFTTAYNGIPETLILNTIFWVLLILLFTVLRHQAGDFGRLALVNSNGSKKRWTEIFYSRAASVVDPQPSTSTQVSPRPSTTSQGVPDSTPLSPIQPEEGLFGWIRVTLKLRKETILLHTGPDAVHYLSFQQHLMAVMALVTIVSLVIILPVNFLNGPKENPYDVNAFGRTTMANLSPDSPWLWVHTIITILYIPLVVLIMRRASGRNAFKKAATRTIMISNISSSDRNKTVVRNYMQELFPDVTIENVSIAYNISRLYVRNAEFERVHEARLYCEHHRNRDTLMVKPEMCSCKKENAYEYYQREERKLSGDVARLRASTMNEPLDIAFITVSTVQEAQNIVTHFTPGTYRQWHLVFAPSPDDLFWENLNVNKSHWYLKFFCVNAVLFLVLFFLSTPAMVVSLLNSRPWVKETEGKISPLVADFLPTLMLWTLSALMPVIVAISDKWMRHYTRSKQNYSIMTKCFGYLLMMIMILPSLGLTSAQALLEWGFLNQTDRWQCIFLPDRGSFYVNYIITAAFIGTALELLRFPELIVYIWSLLKAKSKAETPYIRKAILIEFPFGTHYAWTTLVFTIAIVYSVACPLIMPFAMIYICLKHFVDRHNLYFAYGPSNMISRKGGKIHSTAVTMTKFSVVILVLVMAMICFFRGDNGMARFLLLIISLAITLTLFTFMSPIKRCAATRRPSIVEIAGPAPIYVPDVLKDNGIRTSSVRPSAAAFGGYGSDSVSEYDSSQYSVNSVEA
The following text describes a protein:
Function:
Transcriptional activator that binds to E2f sites. Required for wild-type growth in mitotic and polytene tissues, Contributes to the expression of replication genes at the G1-S transition and Cyclin E. Activates cell proliferation in wing imaginal disk, which requires expression of vg.
Subcellular Localization:
Nucleus.
Domain:
The PIP-box K+4 motif mediates both the interaction with PCNA and the recruitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination.
Sequence:
MSKFFVNVAPINNSNSSSSHTTTSSNTQRHQQHQQHYGGSGTTGHTMVARRLNYDLHGGTTSINNNNNIVIKNESVDLDYDHVLSSSDSNSNGGVAAHLRDHVYISLDKGHNTGAVATAAAAATAGHTQQQLQQQHHHQNQQQRKATGKSNDITNYYKVKRRPHAVSDEIHPKKQAKQSAHHQTVYQKHTASSAPQQLRHSHHQLRHDADAELDEDVVERVAKPASHHPFSLSTPQQQLAASVASSSSSGDRNRADTSLGILTKKFVDLLQESPDGVVDLNEASNRLHVQKRRIYDITNVLEGINILEKKSKNNIQWRCGQSMVSQERSRHIEADSLRLEQQENELNKAIDLMRENLAEISQEVENSGGMAYVTQNDLLNVDLFKDQIVIVIKAPPEAKLVLPNTKLPREIYVKAENSGEINVFLCHDTSPENSPIAPGAGYVGAPGAGCVRTATSTRLHPLTNQRLNDPLFNNIDAMSTKGLFQTPYRSARNLSKSIEEAAKQSQPEYNNICDIAMGQHHNLNQQQQQQQQQLLQQPEEDDVDVELNQLVPTLTNPVVRTHQFQQHQQPSIQELFSSLTESSPPTPTKRRREAAAAAIAAGSSTTATTTLNSHNNRNHSNHSNHSNHSSSNNSKSQPPTIGYGSSQRRSDVPMYNCAMEGATTTSATADTTAATSRSAAASSLQMQFAAVAESNNGSSSGGGGGGGGYGSIAGAGANADPHQPYSHDRNSLPPGVADCDANSNSSSVTLQGLDALFNDIGSDYFSNDIAFVSINPPDDNDYPYALNANEGIDRLFDFGSDAYGP
The following text describes a protein:
Function:
Putative transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MDKCVITGHHFSVENMNHNNNNYDFDNKNNSIGGGGGGGGSSSSRSSSSRSSSNRSSSGSSGGSGSNSSSSINNIINSDNDFKTERKQTKSPPLTLPNIKTTTTTTTTTTTTTTTTTKNENISSSESENSSSRVGSPNCNKKVKKTKTITISPTGYNINSKDDINKFTTYGYTNEKSNARRDPKWINDIIERYNRLKSESLNNNYNGSSSNNNNINNINNNSNNTTSPCQSPSSNTATITSISSPTSSSSSLSSPSFSINNIVNQDVDENDGCDRMNYTLLSQNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTNTNNNGDECIVKPISLIQNKKSGQRSLKTKEHKEILEALYRVTLYPTSEETKTISQILGMTFGQVKSSFRHRREKLSKSGLFSYAKNLKNCGKSTAPLDNFFENCKYLTTKETEEFAAAYDVSFEQIKNYFKGKRAKLNKLSSKAIQDKDNQDNDNNNSNNNENNDDSYSDEGLF
The following text describes a protein:
Function:
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (By similarity). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (By similarity). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (By similarity). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (By similarity). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (By similarity). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (By similarity). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (By similarity). Regulation of transcriptional elongation by this protein is required for the expression of genes which control neuronal development.
Subcellular Localization:
Nucleus.
Sequence:
MSDSEDSDFSDNQSERSSEAEEVEENEEEEEQGSVAGSDKAEEEGEDLEDEEEYDEEEEEDDDRPRKKARHGGFILDEADVDDEYEDEDPWEDGAEDILEKEEAEVSNLDHVVLDEDHSGSRRLQNLWRDSREEALGEYYMRKYAKSSGGEHFYGGSEDLSDDITQQQLLPGVKDPNLWTVKCKIGEERATAISLMRKFVAYQCTDTPLQIKSVVAPEHVKGYIYVEAYKQTHVKAAIEGVGNLRMGFWNQQMVPIKEMTDVLKVVKEVTNLKPKSWVRLKRGLYKDDIAQVDYVEPSQNTISLKMIPRIDLDRIKARMSMKDWFAKRKKFKRPPQRLFDAEKIRSLGGEVSHDGDFMIFEANRYSRKGFLFKSFAMSAVITEGVKPTLSELEKFEDQPEGIDLEVVTETTGKEREHNLQAGDNVEVCEGELINLQGKILSVDGNKITIMPKHEDLKDPLEFPAHELRKYFRMGDHVKVIAGRYEGDTGLIVRVEENFVILFSDLTMHELKVLPRDLQLCSETASGVDAGGQHEWGELVQLDPQTVGVIVRLERETFQVLNMHGKVLTVRHQAVNRRKDNRFAVALDSEQNNIHVKDIVKVIDGPHSGREGEIRHIFRGFAFLHCKKLVENGGMFVCKARHLVLAGGSKPRDVTNFTVGGFAPMSPRISSPMHPGGGGQPQRGGGGGGGGGMGRGRGRRDNDLIGQTVRISQGPYKGYIGVVKDATESTARVELHSTCQTISVDRQRLTTVGGKERQGRSSTHLRTPMYGSQTPIYGTGSRTPMYGSQTPLHDGSRTPHYGSQTPLHDGSRTPGQSGAWDPNNPNTPSRPDDEYEFAYDDEPSPSPQGYGGTPNPQTPGYPEVPSPQVNPQYNPQTPGTPAMYNTDQYSPYAAPSPQGSYQPSPSPQSYHQVAPSPVGYQNTHSPASYHPTPSPMAYQASPSPSPVGYSPMTPGAPSPGGYNPHTPGSNIDQASNDWVTTDIMVRVKDTFLDGGVINQTGIIRSVTGGMCSVFLQDTEKVVSISSEHLEPVTPTKNNKVKVILGEDREATGVLLSIDGEDGIVRMELDEQLKILNLRFLGKLEV
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Sequence:
MSSSVEKGSGSLDPGERPASGSQPKACTACNTTKTPLWRGGPSGPMSLCNACGIRYRKKRREALGLDEPPKKRQPAAAASAAVAAACSEAGGESAEPDQQQQQPKKKTTTTKRGREVELRVVGFGKEVVLKQRRRMRRRRRLGEEEKAAILLMALSSGVIYG
The following text describes a protein:
Function:
Member of the two-component regulatory system YvfT/YvfU. Probably activates YvfU by phosphorylation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGMLLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKEKTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIELEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTKLEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVISPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGNGLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE
The following text describes a protein:
Function:
Catalyzes the oxidation of L-aspartate to iminoaspartate.
Subcellular Localization:
Cytoplasm.
Sequence:
MIERFILPFSEKDFEKEYDLIIVGSGIAGLISAYYAPENFKIALFSKDRLEESNTYYAQGGIAVALNPEDSPELHYKDTLSAGADFNEEKIVKIVVQEGIERVKDLIKLGVNFDKIDGLAFTKEAAHSKRRIIHAQGDATGYEVARTLINIVKDRKNTNIYEHYVLIDLLTYEDEVYGGVFFDTKERKIRIFTSKYIILATGGAGQLYLHTTNPLTATGDGIAIAFRAGARIMDLEFFQFHPTSLDVASPQRFLISEAVRGEGAYLLNAFGERFMLNYHPLAELAPRDVVTRAIFFEMLETQDRIYLDLRPIGEKKIKERFPNIYKKCMEHGIDITKELVPVSPAAHYFMGGIETDEYGRTNLKNLYACGETACTGLHGANRLASNSLLEGLVFGKRCIDAILNEDPAKNHSIPKHQNNLLNISLNEVNQGIKILKKILWDKVGIIRNETELKDAENIIDNLIEKLHNSFILDRSFVELKNMLLISKFMINSALIRKESRGAHFRIDYPKSKEEWKKHIIWEREKEVIFCEVNSLPSFKKNC
The following text describes a protein:
Function:
Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor. Inhibits cell growth and proliferation and may play a role in cell cycle control. Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MQGQEDGDSILPFAKCSRVVSRFSPCSLPPQNRRPMPQPYGDAFWENLSQRSSSNWMVEQYIPPILRATDCSRPSLHPLEGLPPPEKLWRRKRKKLHLERMQKGPGSIPARVRAVTYHLEDLRRRQGIINELKRAQWGSSDATPELPALEEGFELLSTTKYFDVEEERATYPQKETYSVTPRDQLLWTPWTPVGQQGTYASGQLSSLTYSTATARKNPVYDPQAMELESEE
The following text describes a protein:
Function:
Potassium channel. The channel is permeable for K(+), Rb(+) and Cs(+), while it is unable to conduct Na(+).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
In contrast to canonical tetrameric potassium channels, lacks the TVGYG selectivity filter motif and presents a completely different structure. The six transmembrane regions are tightly packed within each subunit without undergoing domain swapping. Transmembranes TM1-TM3 are positioned on the inner circle of the channel tetramer and participate in inter-subunit interactions that are central to the assembly of the ion conduction pore. The RxxxFSD motif within transmembrane TM1 coordinates a network of specific inter- and intra-subunit interactions with other conserved residues on TM2 and TM3 and plays a key role in the tetrameric assembly of the channel. Transmembrane TM4-TM6 are positioned on the periphery of the channel and do not contribute to contacts with neighboring subunits. Transmembranes TM1 and TM2 are linked by an extended strand-like tail and two short helices (H1 and H2) which protrude outwards from the main body of the transmembrane domain and enclose the external open entrance of the ion conduction pore in the channel tetramer. Transmembrane TM3 is bent into two segments (TM3a and TM3b) due to the presence of a conserved proline (Pro-102). Transmembrane TM1 forms the pore-lining inner helix at the center of the channel, creating an hourglass-shaped ion permeation pathway in the channel tetramer. Three hydrophobic residues (Ile-23, Leu-27 and Leu-30) on the C-terminal half of the TM1 helix form a bottleneck along the ion conduction pathway and serve as the selectivity filter of the channel. Ile-23 is probably responsible for channel selectivity.
Sequence:
MVEAPEQSETGRIEAFSDGVFAIAITLLVLEIKVPQHKIVETVGLVSSLLSLWPSYLAFLTSFASILVMWVNHHRIFSLVARTDHAFFYWNGLLLMLVTFVPFPTALLAEYLIHPQARVAASVYAGIFLAIAIVFNRLWKHAATADRLLAQKADRHEVDAITKQYRFGPGLYLVAFALSFISVWLSVGVCFVLAIYFALRSNA
The following text describes a protein:
Function:
Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
Sequence:
MPVKVNIRGQAAAPGSLADSLKDVKLKLVTISGKGGVGKSLVTTSIAVGFAMRGYRVGILDGDVYGPTVPKMLGLSDSTLYVDQKTGRIIPVVGPLGIKVVSIEFALPGDDTAVIWRAPLVNQALRDFISQVEWGPLDVLVVDLPPGTGDAPLTIAQSLQGGLDGSVIVTIPTEISRRIVLKSIDFSRKLNIKVAGVVENMCCFKCPDNGKVYYIFGKDAGKRIAEAAGVPFLGGIPIDPEFSQYLDSGRLHEFLGKDNETAKAVLAISDKLIEMYKDKLSQQTVPKEKPKRISLLKLPGEEEKENY
The following text describes a protein:
Function:
Catalyzes strongly the dephosphorylation of fructose-1-phosphate (Fru1P) and slightly the dephosphorylation of 6-phosphogluconate (6P-Glu). It has low beta-phosphoglucomutase activity.
Sequence:
MYERYAGLIFDMDGTILDTEPTHRKAWREVLGHYGLQYDIQAMIALNGSPTWRIAQAIIELNQADLDPHALAREKTEAVRSMLLDSVEPLPLVDVVKSWHGRRPMAVGTGSESAIAEALLAHLGLRHYFDAVVAADHVKHHKPAPDTFLLCAQRMGVQPTQCVVFEDADFGIQAARAAGMDAVDVRLL
The following text describes a protein:
Function:
Metallothioneins are small proteins that have a high content of cysteine residues which allow them to bind heavy metal ions through clusters of thiolate bonds. MymT binds up to seven ions of Cu(+), with a preference for four to six Cu(+) ions, in a solvent-shielded core. MymT protects M.tuberculosis from copper toxicity.
Miscellaneous:
MISCELLANEOUS: NO and reactive nitrogen intermediates (RNI) can displace Cu(+) from MymT.
Sequence:
MRVIRMTNYEAGTLLTCSHEGCGCRVRIEVPCHCAGAGDAYRCTCGDELAPVK