lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in chromatin organization.
Subcellular Localization:
Nucleus.
Sequence:
MSSSLPTPEGEDLPSQPASKRDPEVPDKEESEEEEEEEDEEEEEEEKEKSLIVEGKREKKKVERLTMQVSSLQREPFTIAQGKGQKLCEIERIHFFLSKKKTDELRNLHKLLYNRPGTVASLKKNVGQFSGFPFEKGSDQYKKKEEMLKKFRNAMLKSICEVLDLERSGINSELVTRILNFLMHPKPSGKPLPKSKKTPSKGSKKERSSSGMSRKAKRTKCPEILSDESSSEEEKKEKDSSEEEDKESEEEPPKKTSKKEKPKPKTPSKSKKSVKSANVKKADSSTTKKNQNNSKKESESEDSSDDEPLIKKLKKPPTDEELKETVKKLLASANLEEVTMKQICKEVYENYPAYDLSERKDFIKKTVKELIS
The following text describes a protein:
Function:
Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.
Miscellaneous:
MISCELLANEOUS: Present with 1440 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MILTTARLNCRPVTVPRLFNRSFSQSFIILKKKSSTPTEKVEEDEIDVNELLKKAETQFKKTLEIQKQKMNEIKQGNFNPKVFNSLVFKNNRKFTDIATTSLKGKNALLITVFDPKDVKTVISGVLAANLNLTPERVPNNDLQLKVSLPPPTTESRLKVAKDLKRVFEEYKQSSLKDSLGTIRGSILKEFKSFKKDDAVRKAERDLEKLHKDYVNKLHDQFQKVEKSIVK
The following text describes a protein:
Function:
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MDKKLNKMPKSTKRAAKLEPQSSDDEEDELEMERNFALLSKKRMNQAPAEDEEDMRDEGESAEEEDEAPEEVEEDDAASDEDESDSEHEDEGNSKTQSHMEGNIKKELSTMSFEEIMALQNKVGTKVYNKIAYGDTKQKKKNEPMKRLNKHRPQEISSKQRVPFLRKVVPVKKMISRDPRFDDLSGEYKPEIFNQTYKFIKNIQEKEAQEVRKQLKKTKSKAKQEELKALLRRMDNQQRARQRQEQEREKELEFKRKQRELVGQGHKPFYLKKSDKKKLELAEKYSELKKSGKLENFLSKKRKRNATKDRRKLPSKHKTR
The following text describes a protein:
Function:
Low-affinity nitrate transporter. Involved in nitrate removal from xylem sap. Not involved in oligopeptides transport.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDQKVRQFEVCTQDGSVDRHGNPAIRANTGKWLTAILILVNQGLATLAFFGVGVNLVLFLTRVMGQDNAEAANNVSKWTGTVYIFSLLGAFLSDSYWGRYKTCAIFQASFVAGLMMLSLSTGALLLEPSGCGVEDSPCKPHSTFKTVLFYLSVYLIALGYGGYQPNIATFGADQFDAEDSVEGHSKIAFFSYFYLALNLGSLFSNTVLGYFEDQGEWPLGFWASAGSAFAGLVLFLIGTPKYRHFTPRESPWSRFCQVLVAATRKAKIDVHHEELNLYDSETQYTGDKKILHTKGFRFLDRAAIVTPDDEAEKVESGSKYDPWRLCSVTQVEEVKCVLRLLPIWLCTILYSVVFTQMASLFVVQGAAMKTNIKNFRIPASSMSSFDILSVAFFIFAYRRFLDPLFARLNKTERNKGLTELQRMGIGLVIAIMAMISAGIVEIHRLKNKEPESATSISSSSTLSIFWQVPQYMLIGASEVFMYVGQLEFFNSQAPTGLKSFASALCMASISLGNYVSSLLVSIVMKISTTDDVHGWIPENLNKGHLERFYFLLAGLTAADFVVYLICAKWYKYIKSEASFSESVTEEEEV
The following text describes a protein:
Function:
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTPGEVRRLYFIIRTFLSYGLDELIPKMRITLPLRLWRYSLFWMPNRHKDKLLGERLRLALQELGPVWIKFGQMLSTRRDLFPPHIADQLALLQDKVAPFDGKLAKQQIEAAMGGLPVEAWFDDFEIKPLASASIAQVHTARLKSNGKEVVIKVIRPDILPVIKADLKLIYRLARWVPRLLPDGRRLRPTEVVREYEKTLIDELNLLRESANAIQLRRNFEDSPMLYIPEVYPDYCSEGMMVMERIYGIPVSDVAALEKNGTNMKLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEHPENPKYIGIDCGIVGSLNKEDKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEEFEFAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYVEGVGRQLYPQLDLWKTAKPFLESWIKDQVGIPALVRAFKEKAPFWVEKMPELPELVYDSLRQGKYLQHSVDKIARELQSNHVRQGQSRYFLGIGATLVLSGTFLLVSRPEWGLMPGWLMAGGLIAWFVGWRKTR
The following text describes a protein:
Function:
Plays an essential role in assembly and/or stability of the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation. Overexpression impairs BMC formation; The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
Miscellaneous:
MISCELLANEOUS: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate. BMCs can constitute up to 10% of total cell protein.
Subcellular Localization:
Bacterial microcompartment.
Sequence:
MNGETLQRIVEEIVSRLHRRAQSTATLSVTQLRDADCPALFCQHASLRILLIDLPLLGQLADAETGDAAARKIHDALAFGIRVQLSLHSQLLPVIPVKKLARLPLVFTDEHGLPLVLHAGSVLSYRDVALLSRGRVVVHRKCIVTAMARDAANARNIQLIKQE
The following text describes a protein:
Function:
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKSLTVLSEKTASLVNSTDQQLEFDTLNPSSYLGLGIAVDSDSHHVYVALHSAADSTQPNATIAIYRISEHENAPFDIARINLDSDTALLHNPTIAGMQYLADSCSLCIALHSGDIFLARFDHSQNNTLSPTVECVGIIDSGIKTMSWSPDLELVLFVTGSGTILEMTQEFEMISEAPIHVDSHGEVIHLNRIFVAIPVSVGWGKKETQFHGKAGKQAAVESTLPVTDAIHISPDDTMAPSLTWRGDGNFFACSSVNESKQMRTICIYDREGVLQSTSEYVAQLEHPLCWRPSGNLIAASQRLPHRHDIVFFEKNGLRHGEFTLRNAQDIVLDLQWNSDSTVLAICVEQVVDEHRVTVVQLWVCNNYYWYLKQEIFPTSTHASFVSILWDPEISTKLHVLCANGDYRRFQFSSDVLTSSSLSPENEAVVAVIDGANVLLTPFRSKNVPPPMSYSKVVLPCSAKHISFSPSVPVNRMSVLLANNTIQFWDNIHQDTASLEMIGQLVLSKCEHQIRQISWVESNVLVALAYDTSLHTDRVIAYTFDHSTTNFTVIDTKEISYQKQYMEVLRLYNSISDKVLALQLLSGTILQIKKIGDSWCAVDVLTFPSVCTWMACVCLGESKDTKEMAWIGLSERNKLFLNDQILSVDCTSFLIHKEFLIITTLTHTARFLSLSLPLYEFKFDEHTHNTVFNELHRRVERGSHIIVADVSDVKLVMQMPRGNLESVFPRALVLSTIRHAIDRLDYKTAFIACRKHRIDMNFILDHAPDAFWLHIEDFVRQVDDIDHLNLFISSMRNEDVTKTMYSAKKTMVDVDVKDKVNMVCQRMKAVMDTIDATKYIQPILTCAACHQPPDIESAMRRIYTLKTTHSLSAAETALMYLIFLVDVDKLYDVALGMYDFGLVLMVAQHSQKDPREYLPFLKGLQVLPMYYQRFSIDDHLAKHASAIRNLSQAGDEHFEELIAYLKRHKLYQISITLYPKDSAKHKTMLLEFAEFHSNNGQFDEAAMLYDMAGAYPQALEAYTNAGQWQEAYTIAINTSISEFELTQMAETLIEILTERREFQSVARICLDILNDCQRAVEALVAGFFWKDAILVLTVHKQPSLKESMVYPSVIKAYDHTLMEVEEMTVTFDKQRSRLAQVRREKQRQQASAAAGGEPTDDRLDDIDMFSDTSSMATTRISGSVTNSRASMMSSRTGRTSKQRRKMARRRAAGKEPAFEDEFLIASLCKIVKRSTVLSQDISLLIRALGSFNEMDRASKVQGYFNELLNVIKRGYKEIFIVEEAQQTKDEKPAVVVFGGKDKSDAVDRDVILPVPIVIEKPPMVSDKWWTDSFSMDTIAKSL
The following text describes a protein:
Function:
Glycerophosphocholine acyltransferase (GPCAT) that utilizes acyl-CoA to acylate glycero-3-phosphocholine (GPC), forming lysophosphatidylcholine (LPC). Shows broad acyl specificities with a preference for 16:0-CoA, polyunsaturated acyl-CoA, and the hydroxylated ricinoleoyl-CoA. Also catalyzes the acylation of glycero-3-phosphoethanolamine (GPE) with acyl-CoA. In addition to acyl-CoA, GPCAT efficiently utilizes LPC and lysophosphatidylethanolamine (LPE) as acyl donors in the acylation of GPC. Contributes to the maintenance of phosphatidylcholine (PC) homeostasis and might also have specific functions in acyl editing of PC, such as transferring acyl groups modified at the sn-2 position of PC to the sn-1. Involved in postsynthetic PC remodeling that produces more saturated PC species.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MYKLDNNDIDDETNNSVSLTSLLEFLDPIASKVVSKYYHGSHLSKAEQKLRNFEGFRRRKPHHEHDSHHPHHLNRSRSFLQLEDFKVRALQRIRNLDKPLDSIFFKNSSRLEKAFYPFTLFNIFFIGFLMGRFPEWFHVYYTILFFVLMPIRFYTYYKTKNHYFLADFCYFVNMLCLLFIWIFPYSYSLFQSCFAFTFGTLCFAVITWRNSLVIHSIDKTTSCFIHIIPPCVMYVIYHGLPLEYKIERFPGAIIQSELDIKKNILWTSLYYLVWQSLYHYFITLKKSSKIKSGERMTSFEYLTTHQFKNFWAVKLRSPWPMIIYTLSQYFYQLFTMLLCGIWIRYKLAAALFLTIVFLWASHNGATYYIDHYGKNFEKEVDRLRLEVENLQQKLQPDSDAVISDASVNDKDYLNVNRDEDFDDSSSVSSKSD
The following text describes a protein:
Function:
Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity). Controls adaptive responses to salt/osmotic stress. Acts as a key glycosylation determinant for EFR function during plant innate immunity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
Despite low primary sequence conservation between eukaryotic catalytic subunits and bacterial and archaeal single subunit OSTs (ssOST), structural comparison revealed several common motifs at spatially equivalent positions, like the DXD motif 1 on the external loop 1 and the DXD motif 2 on the external loop 2 involved in binding of the metal ion cofactor and the carboxamide group of the acceptor asparagine, the conserved Glu residue of the TIXE/SVSE motif on the external loop 5 involved in catalysis, as well as the WWDYG and the DK/MI motifs in the globular domain that define the binding pocket for the +2 Ser/Thr of the acceptor sequon. In bacterial ssOSTs, an Arg residue was found to interact with a negatively charged side chain at the -2 position of the sequon. This Arg is conserved in bacterial enzymes and correlates with an extended sequon requirement (Asp-X-Asn-X-Ser/Thr) for bacterial N-glycosylation.
Sequence:
MAALESPLPGTPTAMRNAFGNVLSVLILVLIGVLAFSIRLFSVIKYESVIHEFDPYFNYRVTQFLSKNGIYEFWNWFDDRTWYPLGRVIGGTVYPGLTLTAGTIWWGLNSLNIPLSVETVCVFTAPVFSAFASWATYLLTKEVKGSGAGLAAAALLAMVPSYISRSVAGSYDNEAVAIFALIFTFYLYIKTLNTGSLFYATLNALAYFYMVCSWGGYTFIINLIPMHVLLCIVTGRYSPRLYIAYAPLVVLGTLLAALVPVVGFNAVLTSEHFASFLVFIIIHVVALVYYIKGILSPKMFKVAVTLVVSIGMVVCFIVVAILVALVASSPTGGWSGRSLSLLDPTYASKYIPIIASVSEHQPPTWPSYFMDINVLAFLVPAGIIACFSPLSDASSFVVLYIVMSVYFSGVMVRLMLVLAPAACIMSGIALSQAFDVFTGSIKYQLGASSNSTDDAEDNTSTNNAPKDDVSAGKTDKGEEIVKERSSKKGKKKEREPADKPSVKAKIKKKALVLPLEASIVALLLLIMLGAFYVIHCVWAAAEAYSAPSIVLTSQSRDGLHVFDDFRESYAWLSHNTDVDDKVASWWDYGYQTTAMANRTVIVDNNTWNNTHIATVGTAMSSPEKAAWEIFNSLDVKYVLVVFGGLIGYPSDDINKFLWMVRIGGGVFPHIKEADYLRDGQYRIDSEATPTMLNSLMYKLSYYRFVETDGKGYDRVRRTEIGKKHFKLTHFEEVFTSHHWMVRLYKLKPPRNRIRGKAKKLKSKTSSGLSSKSAKKNPWV
The following text describes a protein:
Function:
Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MWRRRRRRRMVMERGGVRRAAAPRGRSRLPWRRGGAEGAGRREQGEEGAEEEEEEEEGPAGPDGAVGVRAAEREAMEGAAGPGSRTAAFPFFGRRRRRRERERERERERGPGRSSRPPPPPGPGPGPERSPPPAPPAPGPGPGSGSSSAAGGPGEAWGGWGGRSRGFFSLLLRRGGPAAAPPGEPPAPALGRQKRGLRAVLGALRWPRRPKDRPGDRTPRAPAPPDDDDDDDDDEEPPGGPRPGPPTAPAGHGPPEIPEAGAEEEEERERAEEAAPTAEAPPRPRPPGGPDRPAAAGDPPSEPSLDRICLLLADVASLKSFDSLTGCGDITADPEDEAGPPGAPGAPGAPGAPGPDRARPAPSPKKPKAPAFQGGGEGLATPDGRQMPRTPGTRGAGKGDADRPPDGPRDGARDGAPDSAPDRAPERARDGPPDGPPDRAPDRVPDAAPDAAPDGAQDGAPDGSLDKASDRPPERPSDGPPERPPDGPPERAPDGAPARAPAVGAREGSAAARPRLHRIPIPVPHKEDPADREKEPQEGVPNSDEGYWDSTTPGPEEDGAHRLQKEGLPRDSCSGDALYDLYADPDAAPDPEAPGGGPRSKPASPGPVTGSLKTPGGALKDSKIPISVKHLPAGHHVGHHLPPRSEAPRTKIPVSKVLVRRVSHRGLVGTALRPATACHDSAKKL
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA.
Sequence:
MRMEVTRENFYRRLDKFLRNQLKDVPLSVIYKLIRKGKVYVNRKRVKDPSFDLEEGDVVELRYVNLENLPKRSEKKDLTPVPMKLDVLYEDDHYLVLNKPPNIAIHPGKGVHVATLIEGLLYYGQEKGFSPFLVHRLDKETSGLLVVAKNREAARILTELFKGRNIEKEYVTLVRGVPENNMKITIPLDGQEAVSEIVSVKPLKDVSLLRVKIHTGRKHQIRRHLSQIGFPVVGDDTYGDRHFNREFRKRYGLKRQFLHSYRMKFIDPWTEEEKDFRAPLPDDLLSVLNLLEERSDEWLEEFLS
The following text describes a protein:
Function:
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.
Subcellular Localization:
Chromosome, centromere, kinetochore.
Sequence:
MPQNGAMGTANVWWEDYQSAAHVSLTGGMSINPLFISAGPFPTPANLPTLGSLQKKHRARVFPPNNNVVNRGFAQYDVFGTGSHDATGERQTSVLIECSWKDVTSVLQLPPYNSDTVMHIRAVPGDMKSAAYNIYRELQTLSGFVEGLKTGEVLWCLEENATPLTTTVSNFIQEFTELHVKKPALQKVQNEADINSPMHSMLLPPRKDLDFTEALWEKLLGCSGYQELVECLQLVCTALQQGKIQPMVHRSNQSELACLVRESFKGAMRAPDLDGLLPVRLLAEIGVEKMKRDYTHFFIAEELTTLSQLSAYLKTDASLEDNLALLHKLHVILEMVAACKAFLDLPHENLRTLLGMALQHYGNHCHDDGHTFQLPLSAGACVKRVYERSQAAVWRLEQTSGGKDDQVTSVCQISTRPLYDHAVCDVGDMTLGDPMADTQPNFLTTVQQSRVSFT
The following text describes a protein:
Function:
May be involved in vacuolar sorting and osmoregulation.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MKLTKAVFRFRRTNLSTLLVITYLVITTLYVWDHFRYHFTLPSDYNYAQMLADAWLDLEIITQYPHPYASHANDKVHDYLLDRVKEITRDSMFAEISDDYGMGLRTLFRQEDAISGTKESTVVYYESSNVLARVQGRNSALDGLLLSAHYDSVPSGYGATDDGMGVVSMLAILTHYVKNQPERTLVFNFNNNQEFGLAGASAFFEHPWSKEISYVINLEGTGAGGKAVLFRTSDVSTAQVYAEAVRQQPFGNSMYQQGFYNGHIGTETDFQVYEDQGLRGWDIAFYRPRNLYHTAKDTVLYTSKQALWHMLHTALQLTDYMAINKPDMEDTSNAVYFDLFGKWFVVWSARSLFYWNCIILALFPSILAILFLVAYDMQLLKFNFWDAMLRLPVSVCLAYFCVKLFQVLVGQLNPYVFSRDYVSPILAEASMFIFMNYVILSSWERLRPLRDFKTVALVEVSMVLWIYLISVTRWLRDSDYTATGLYPFTIGYTFVSIGAIIGVFCATFKAKLNPEDDSYVGDSKVDIEQQQMLMQHQYQQHSQKHSNQHSPHHSTHHSAQHSVHHSPRQSIHQVPSSEQRQRDASETPHVIISVDHTAGHQEDSEVTPLLNTGTVAPFPKPVPERVSRKSFLRNVVTSILNYDWSIQFMVVTPWVTYFTWICLDLIMGAMNQTIQESAKGTTFVTHMALIGSLLLSLPMLPFTYKLHSFAGMLFLLLAVTTAVWTIVAPPFTESSPLKLRFLQTIDLDKNNSSSVYLYGRERTFMEPILDDIPSVTKYRCVEYAGDGVDICEYNGMPPRMFNNHHEAESDWTKIMTLEILKDDRNSTSRTPYQPITAELKINVEENRVCTLNFNSTAFKNWKQGVSPLREVVILHENPSSNVTPSFYNTAMKNGYYQDEFGNDHYRWNNGITELQLHKLDFKRGYYKIGLEWIPQLLYRGYDPATSSSEEDDALGVSVTCYWGEYDTDSITDGFATTNVPAYDELRKYSPKNIIYSSKEKGMVSVTKYVEL
The following text describes a protein:
Function:
Member of the dosage-dependent hierarchy effective upon white gene expression.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSAPTDQPPRSEGAQTNSSERSSQQQEQPQQSQSQNVPAKLLQHFQTNRIDSALWALRLLVIFFTVSYVLPIFTSQQSAFSKVMLANAAISALRLHQRLPAFAFSREFLARLFAEDSCHYMMYSLIFFNIRPSLLVLIPVLLYSVLHASSYSLKLLDLIGQNSWWGARFIISIVEFQAANILKATAFCEIFIMPYAIVLAFMNHAGLMTPVIYYHYLVMRYSSRRNPYPRNAFAELRITFEALAARSPPAFAKIIRGGIGFVNRLAPQLQPAAAQE
The following text describes a protein:
Function:
Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.
Subcellular Localization:
Nucleus.
Sequence:
MNNLNVFTNEDNEMNVMPPPRVCPRCYSDQTRFSYFNNNKKSQPRYKCKNCCRCWTHGGVLRNIPVTGICDKSNLPKIDQSSVSQMILAEIQQGNHQPFKKFQENISVSVSSSSDVSIVGNHFDDLSELHGITNSTPIRSFTMDRLDFGEESFQQDLYDVGSNDLIGNPLINQSIGGYVDNHKDEHKLQFEYES
The following text describes a protein:
Function:
Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
Sequence:
MSFMEDVSDVSESSNYDEWITSFCSRFGHEFFCQVPTEFIEDDFNLTGLSAEVPHYRRALDLILDLESLSEEDEDGVAASAGAASNGGDHSNGTSVRQAAHADGQPINKSIIDHCAEQLYGLIHARYILTKQGLQAMAEKFDHKEFGTCPRYYCGGMQLLPCGLSDTLGKNTVRLYCASCQDLYLPHSSRHLCLEGAFWGTSFPGVFLKHFKELEDYVEQKNKNVYRLRIFGFPVAKESISGPRMEWLRQYPSTEAEWQEFEKCEYEILKLEDQE
The following text describes a protein:
Function:
Carboxylate--CoA ligase that may use 4-coumarate as substrate. Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioester.
Domain:
Both substrate-binding domains (SBD1 and SBD2) are involved in the substrate recognition, and are sufficient to confer the substrate specificity.
Sequence:
MQRDAIAAARNAGCSSGRISQPPPPPFYSAATGIYSSIHPPVALPTDPSLTLVAHLFARLPLADPGAPTLVDAATASAVSRADLRRLVASLAAGLRRRHGVRKGSVVLLLLPNSVAFPVSFLAVLAAGAVATTMNPSSSPAEIAAQARATGACLVLASRDGAARLPPLAAPVVLVPEILDHSAAADDGDDDQRVFAAFRAMLDGGGGDGTETAVPVVGQDDAVAILYSSGTSGRSKGVVLTHRNLIAMTELFVRFEASQYHARGARENVYMAALPMSHVYGLSLFAVGLLSIGATVVVMRRFDAGDAVAAIGRYKVTHMPLVPPIMAAMVRAAAAGGVPPSQVASLVQVSCGAAPITAALIHEFLQAFPHVDFIQGYGMTESTAVGTRGFNTSKHKKYTSVGLLAPNMHAKIVHLESSSCLPPGFSGELWLHGPGIMKGYLSDDDDACTRKDGWLRTGDIAYFDLDGYLYIVGRLKDTIKYKGFQIAPGDLEEVLIHHPEILDVAVTSAEDEEAGEIPVAFVVRRSGSNLSCKQVMEYVAKQVAPYKRVRKVVFVEAIPKSPAGKVLRRLLRNSHDTAAAATSSCSISSKL
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Sequence:
MKILTFGEALELQEEISRDAAGRLNMLGRQILSRGFARTYIAPSLDHLSRGKGVPGLFSSDGLQGAWFDRAEHYAQMLTAVARSGEQRPVATLVQELATQGGRRREHMYATLLHNLRFAFSTLQGCAQPAPTAAPAAALLQTPSLELQGPNEPLEAGCTRLHAALTQSFGSIAEFRTLLLNSSLAQSGDGFTWLVARCAGDTGDALAYDKLFVFNTYNAGSPHAVSRVEHFKRVVKTETEPKPMDGTKEAVQNLQYKATTRYYPLLAIDASPKSWLHDYGVFGKAAYLDRVWESTNWTAVESRLPQQRSETFI
The following text describes a protein:
Function:
May have a role in meiosis and sporulation.
Subcellular Localization:
Cytoplasm. Note=Barrier septum.
Sequence:
MMTRMELRPLEIGFSKALTEVAPVTCQCECWDHNLCSSQASEMDLIYQSQDTHSCASKQDAVFQLLSETKIPVPNRYRKISHRLSTLSNKKTLKSQLDRFLSSSKKLHNDDVNRGDYCFLLSTPVECSASTNSHSYDCLWNFSCNSFPEYSSYSASETSSVASYSYYSGPNPATPSSSSCNLVNANSLDIYLNINNLKKSKSVPRLRGQFMEPVEHNHPLSKSLEEQSSFLEQSKDASSNLTACNRSGSSLSSNFYSSRLSKKTSLASLNKSRASLQHKIMSLSRNIIRRVFHKPEVHLDPSASILNLSSSHGESNLTNGLLCQNFKLFQDDWLMEDCAPDANFTLYTPLQPWEKRSVKPEIRRPRLNPNFFRVFVLEAQMRRAGKLSANTAGRAQLIYLPKPAVTFSTSPLHVEL
The following text describes a protein:
Function:
Binds 23S rRNA. It is not essential for growth; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. Contacts trigger factor.
Sequence:
MKAKELREKSVEELNTELLNLLREQFNLRMQAASGQLQQSHLLKQVRRDVARVKTLLNEKAGA
The following text describes a protein:
Function:
Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MDDGAPEPTTVGEQQPPSGKLNKTAFKLFKRRKSGGAMPSIFGVRSSKGKGDGGGAGGERAAVASPVPAPAGGLVRSKTHDGLAEVGLEGAVKKEKEAEEAEAPASPPSSSPSSSAAVGKSHSFFSLLRKNGGGAKGERPKGRGGGGLKGLFNSMRWSRRETHKPVGGKGEGGDGPGLMPGSLTASLECIKEEAPPPPKQPLPPSSGEGSPKASPSLLLDSDGDKAPELDDTWELMPALLSPLGEDLPGMLAQVKKGSGLESPPPLSGQQEKPQEEEEEEEEKAASAAITGCGDIIADHEGDAGGGGGVSGGGGGSSSSEKSVPGASKKPVSVGGVLTYQGGGEEMASPEQVGDTCAPEFWDVLSQTSRGKESPKASKEVNGAKGVQDGSASGQHVGFNHSHKEDQKSRDKEQQEAIPSGDEGYWDSTTPGPEEDTTNNIQKEVIPRDSYSGDALYDLYTEPEENTATTTSAEDVATGTCGKPLSPVTTTCPVKTHTTSLKDSKIPISIKHFTSPHSSHGPDTSNSHHIAHHHPTKSEIPRTKIPVSKVLVQRAGYRSLAGTTGKAATYHESAKK
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLSMVDFIFTHMAASVLQQSPSSPLRSLSPLSKSFPQIPCPRQRRHGGREKSRWNTASLTGEDWSSYSLSAATSHILLRSNHESNGIPMDDTNQSLPSCARSSNRAVLTVSTKTSKILMANDKACRLFEYSSPELIGMSLSQLIPASSHRVSEALEDELTESDGFSRVPGEVVEAVRRGGETITLCMWIRRIQNQCLLLLETVQQITATVSFRQDGRILSCDPTCARLYGYMEPEEVLGQHITDLLPTVNIPLQGREIPQNLRCQRLVGVTRDGANFPLSLNLSEASVDTGSHVEEYCASLSILSSINGLITLRPDGSIRGLNGSFSNSLFGYDRTQLLGKNITFLIPGFYHYMRSAGDEPSPLLTPLGETLDTSGSSDMISSNATKEKSSEHDTFHNPLSDGNWLQAPACCILQTSQTPLTRAVNNQEMAVSSAPENDYLQSVPTCCVSPGTPTQDEPWEREKYTRHDLDLESGITPLTHCLRTLSLSKSQSEKKEAHQHINSHQVFPTVEKAFSPVLSPCPSAVGEIHQPPNALGVSPPITVQVTRLPGSPSFLSETTSIPLRNVCSNAHHHGTLLQAEITHNMNETNAARSTPSANNIPVISSPPLCHHNPVIKTASVIHANNAGANNTPSSTLHNNLSLSPVSTVSFSEYIMQSTANTSCSPDKIPTIVDADSCPTSSVLSPLPTELSTENKDSESLVGGVFLYNRNSPTPNLSPCRSVEPDAVNRLSREESSPIPPSQEGESNRYSSETLSQVTSTPVKDDSPHSLQLESADLSHKELQVPFAGGEIREGIFNGSCYHRDGSRLFIQFDVQRTVSAGSYLFNVWVSKDLLQSQRDAIARTRLLLSSFASSSQSLLEQSERSLGELIRNSANAGYCTELQDLQIVGACNGQYALKYQTVSPLGKGAFGFVWSACGRDSAKEEVVVKFIRKDRVLDDCWVQDPELGKVTQEIAILSRVQHPNIIRVVDVFENDTFFQLVMELHGDGLDLFDFIDSQPSLDEPLASYIFRQLVSAVGYLHNQHILHRDIKDENIIIAPDFSIKLVDFGSAAHLHQGTLFSTFCGTTEYCAPEVLLGNPYPGPELEMWSLGVTLYTLIFGENPFCEVDEILEAELNPPFNVSQKLQVLISGLLQRDPEIRMTLDELLRDPWVTQPINLAEYTWEEVYPPASSHKDDDGPGLCPDSYKSEWNEEFQNQPQ
The following text describes a protein:
Function:
SNARE required for protein transport between the ER and the Golgi complex.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein.
Sequence:
MNTTFNSALKQSTSIRKDLAALSSHELDPTSLTPAALGSLSASLTAFNRTIDEYNHLAKQELNAAKQEKAYERIRNFRSELHDFRTQLDSLKSKREEHMHAQNRAELLGRRPFVASTPENPYAGAGATATSSATGGGGYGISHARTNSLAESGRMQSSSSSGILGSGDASREQHALREQDFFRSTHSALDDYIARGQAVLGDLNQQREIMKNTQRKLYSVGNTLGISGDTIRMIERRAKQDKWIFWGGVVVFFLFCWLVLHYLR
The following text describes a protein:
Function:
May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation.
Subcellular Localization:
Cell membrane; Single-pass type III membrane protein. Cytoplasmic vesicle membrane; Single-pass type III membrane protein. Note=Predominantly on lateral parts of the membrane, at cell-cell epithelial junctions. Detected on cytoplasmic membranes in undifferentiated tumors.
Sequence:
MTSLLTTPSPREELMTTPILQPTEALSPEDGASTALIAVVITVVFLTLLSVVILIFFYLYKNKGSYVTYEPTEGEPSAIVQMESDLAKGSEKEEYFI
The following text describes a protein:
Function:
Decoration protein that binds to each capsid protein hexamer after capsid expansion and forms spikes at the surface of the capsid. Each of the 60 hexamers has three copies of the decoration protein gp12 in its center.
Subcellular Localization:
Virion. Note=180 copies of the decoration protein are localized on the exterior of the capsid.
Sequence:
MSKRIPRFLRNIQLPAGPQGPKGDPGPKGDTGAKGADGFGTEAQYNDIISRLEALEQSSGGGTT
The following text describes a protein:
Function:
Inner membrane component of the type IV (T4S) secretion system that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility. PilN/PilO heterodimers form the foundation of the inner-membrane PilM/PilN/PilO/PilP complex which plays an essential role in the assembly of a functional T4 pilus. PilP connects PilO to the secretin PilQ. In turn, the PilM/PilN/PilO/PilP/PilQ complex facilitates transit of the pilus through the periplasm and clamps the pilus in the cell envelope.
Subcellular Localization:
Cell inner membrane; Lipid-anchor.
Sequence:
MRARLILSSLLLASLAGCGGGSDFADLQSYMDEVRARPKGTIEPLPKFQPYEAFTYSAASLRSPFQPPVKIDLTVRQKGNKVIKPDETRVKQFLEGFNIETFEMVGTLSNAQGTFALVKGAGGVHRVRVGDYLGRNDGKVVGISEGKIDVIEIVPDGEGNWLERPRSLTLKERS
The following text describes a protein:
Function:
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Subcellular Localization:
Cytoplasm.
Sequence:
MTPDHAHTPEGTEPMTQKVAVLGTGKIGEALLSGMIGAGWAPADLLVTARRRERADELRARHGVTPVTNAEAAKAADTLILTVKPQDMGTLLDELAPHVPADRLVISGAAGVPTSFFEERLAPGTPVVRVMTNTPALVDEAMSVISAGTHATAAHLTHTEEIFGAVGKTLRVPESQQDACTALSGSGPAYFFYLVEAMTDAGILLGLPRDKAHDLIVQSAIGAAKMLRDSGEHPVKLRENVTSPAGTTINAIRELENHGVRAALIAALEAARDRSRELATGTKD