lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Low-affinity, high capacity permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKPYEGLYSFYKILTRTKHVTLEGTGSSDLCRCLSTLDLVALGVGSTLGAGVYVLAGEVAKVDSGPSIIISFLIAALASVLAGLCYAEFGARVPLTGSAYLYSYVTVGELWAFITGWNLILSYVIGTSSVARAWSATFDELVGKKIGNFLGNTMHMDLPGLAEYPDIFAVCLIILLAGLLSFGVKESTAVNKVFTAINILVLLFVIASGCVTGNLKYWKMSKEDLWATKQSVSNHSIGNETGLDFGAGGFMPFGFSGTLAGAATCFYAFVGFDCIATTGEEVKNPQKSIPLGIVLSLSICFFAYFGVSASLTLMMPYHLLDSQSPLPAAFEYVGWNVAKYIVAVGSLCALTTSLLGSMFPMPRILFAMARDGLLFQPLSRVSSRQSPVIATIVSGVVAALMAFLFNLKALVDMMSIGTLLAYTLVSTCVLLLRYQPQTDFGKSPDGNLQEQNISSISHLPETPSVHSSALVTRCVIAITLLVCVASVVSTVGSQCLLSGRAWCLSLLVLSLLGIIIALVIIWRQPQNQSKATFMVPFVPVLPVVSILVNIYLMVQLSTDTWLRYAVWMAVGFVIYFGYGIRHSIERLHLKETCTQKMAISSTETLCKAQCLELQLGEAKPMD
The following text describes a protein:
Function:
Acts as a transcriptional activator.
Subcellular Localization:
Nucleus.
Sequence:
MASTIKEALSVVSEDQSLFECAYGSPHLAKTEMTASSSSEYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPNQVNGSRNSPDDCSVAKGGKMVSSSDNVGMNYGSYMEEKHIPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVDILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGATFIFPNTSVYPEATQRITTRPDLPYEQARRSAWTSHSHPTQSKATQPSSSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSNCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSMYKYPSDLPYMSSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPAAHMPSHLGTYY
The following text describes a protein:
Function:
The M ring may be actively involved in energy transduction.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Bacterial flagellum basal body.
Sequence:
MNRTLMQMKNKTSEFWKNRSKLQKILMVSALAAIIIIGIIISVFASNSKMAPLYKDLSAEEAGQIKEELDAKKVPNELSNGGTVISVPEDQVDSLKVQMAAEGLPKTGSIDYSFFGQNAGFGLTDNEFDMVKVKATQTELSNLINEMDGIKNSKVMINLPKDAVFVGEEQSAASASIVLQIQPGYTLDQSQINGLYHLVSKSVPNLKEDNIVIMDQNSTYYDKSDSDAGSYADSYSSQQGIKSQVEKDIQKHVQSLLGTMMGQDKVVVSVTADIDFTKENRTEDIVEPVDKENMEGIAVSAEKVSETYQGDGAANGGTAGTGEEDVTNYKADGENTESGNYEKNSNKINYEVNRIHKEIAESPYKVRDLGIQVMVEPPDAKNTASLSTERQDDIQKILSTVVRTSLDKDETQNQNLSDADINNKIVVSVQPFDGKVNLDTNTEESSGIPLWAYIVGGVLIAAIIVLIIMLIRKKRAQEDEFEEYEYEVPQEPINLPDINEEENETAESVRRKQLEKMAKDKPEDFAKLLRSWLAED
The following text describes a protein:
Function:
Endonuclease that cleaves only one strand of asymmetric DNA substrates thereby introducing interruptions into the template or coding strand.
Sequence:
MQFVPIKDAPGYLVNEAGDVFSTFTNKVLSRYIVDGYPAVKLQINGKQTSVLIHRIISHVFGDLYNLFDPELEVDHKDRDRLNLSKDNLQVLSKIEHQRKTNKDNGWSDSRVPCPLCGSLMLQRSVTCTNCKPKPTGRLIKPELSLDDITEKVLLMGWVKAAKELEVSESTLRRRYTKLTGLSPKVLTEQRKSK
The following text describes a protein:
Function:
Required for resistance to the phenazine antibiotic D-alanylgriseoluteic acid (AGA), an antibiotic produced by E.agglomerans itself, and thus protects the bacterium against phenazine toxicity. Probably binds AGA and acts as a chaperone that works in tandem with a membrane transporter for subsequent antibiotic secretion.
Sequence:
MTDLAGPTITPNLQLVYVSNVERSTDFYRFIFKKEPVFVTPRYVAFPSSGDALFAIWSGGEEPVAEIPRFSEIGIMLPTGEDVDKLFNEWTKQKSHQIIVIKEPYTDVFGRTFLISDPDGHIIRVCPLD
The following text describes a protein:
Function:
Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MIKLFIKYVSIGVLNTALHWAIFALCVYGFQTSQALANVAGFAVAVSFSFFANARFTFGASVSTGRYLLYVGFMGVLSAVVGWTGDKCAMPPIFTLIVFSAISLICGFLYSRFIVFRNEK
The following text describes a protein:
Function:
Central component of the spindle assembly checkpoint. Has a role in the correct positioning of the septum. Required for anchoring mad2 to the nuclear periphery.
Subcellular Localization:
Nucleus.
Sequence:
MSSKLTVYQATTSMADSPRDPFQSRSQLPRFLATSVKKPNLKKPSVNSANETKNPKLASLEFQLENLKNDLKRKELEFEREQIELQRKLAEEHEQKNSLQLRLTLVEKQLEEQSTSYQKEIEEVRNEKEATQVKIHELLDAKWKEIAELKTQIEKNDQALSEKNHEVMVSNQALQMKDTNLTNLEKLFADSREQLETKCKELAAAEQQLQELSVHNQQLEESIKQVSSSIELEKINAEQRLQISELEKLKAAQEERIEKLSSNNRNVEILKEEKNDLESKLYRFEEYRDKVATLELENEKIQTELNSWKSLITNELPTPEAVSNKLVFLQNTNANLGERVSSLESQLSNKPANQPLGANEKDAAHITELETKLKELHEQNRRLQRQKSLATQEIDLLRENLKSYDDEEAILSEKNTDMKKLERIEGLVKLVDEYKLKLESMPVSLDVDETSDEVSLQKRRRKNEHKDAGYVTELYRKNQHLLFQVKEKTNIEAFLREQIITLESSIATLRQELAQVTEINSCRVLQHRSNPTLKYERIKAAQLEMLNAENSALKALLEDKKVDCLPIQSFKIAERKALDLKKEVAEREKRIQRLKEIFSVKSLEFREAVFSLFGYKLDFMPNGSVRVTSTYSREDNTAFIFDGESSTMKLVGNPSGPEFERLIRFWCDERKTIPGMLAALTLELLDKND
The following text describes a protein:
Function:
Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
Subcellular Localization:
Cytoplasm.
Sequence:
MLSLQEFVQNRYNKTIAECSNEELYLALLNYSKLASSQKPVNTGKKKVYYISAEFLIGKLLSNNLINLGLYDDVKKELAAAGKDLIEVEEVELEPSLGNGGLGRLAACFIDSIATLGLNGDGVGLNYHFGLFQQVLKNNQQETIPNAWLTEQNWLVRSSRSYQVPFADFTLTSTLYDIDVTGYETATKNRLRLFDLDSVDSSIIKDGINFDKTDIARNLTLFLYPDDSDRQGELLRIFQQYFMVSNGAQLIIDEAIEKGSNLHDLADYAVVQINDTHPSMVIPELIRLLTARGIELDEAISIVRSMTAYTNHTILAEALEKWPLEFLQEVVPHLVPIIEELDRRVKAEYKDPAVQIIDESGRVHMAHMDIHYGYSVNGVAALHTEILKNSELKAFYDLYPEKFNNKTNGITFRRWLMHANPRLSHYLDEILGDGWHHEADELEKLLSYEDKAAVKEKLESIKAHNKRKLARHLKEHQGVEINPNSIFDIQIKRLHEYKRQQMNALYVIHKYLDIKAGNIPARPITIFFGGKAAPAYTIAQDIIHLILCMSEVIANDPAVAPHLQVVMVENYNVTAASFLIPACDISEQISLASKEASGTGNMKFMLNGALTLGTMDGANVEIAELVGEENIYIFGEDSETVIDLYAKAAYKSSEFYAREAIKPLVDFIVSDAVLAAGNKERLERLYNELINKDWFMTLLDLEDYIKVKEQMLADYEDRDAWLDKVIVNISKAGFFSSDRTIAQYNEDIWHLN
The following text describes a protein:
Function:
Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. May have a role in cell-wall turnover.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDTTELVDLAVIFPDLEIELKYACADNITGKAIYQQARCLLHKDAITALAKSISIAQLSGLQLVIYDAYRPQQAQAMLWQACPDPQYVVDVTVGSNHSRGTAIDLTLRDEHGNILDMGAGFDEMHERSHAYHPSVPPAAQRNRLLLNAIMTGGGFVGISSEWWHFELPQAASYPLLADQFSCFISPGTQHVS
The following text describes a protein:
Function:
Involved in the maturation of [NiFe] hydrogenases. Along with HypF, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypE catalyzes the ATP-dependent dehydration of the carboxamido group attached to its C-terminal cysteine to a cyano group. The cyano group is then transferred from HypE to the HypC-HypD complex or the HybG-HypD complex.
Sequence:
MNNIQLAHGSGGQAMQQLINSLFMEAFANPWLAEQEDQARLDLAQLVAEGDRLAFSTDSYVIDPLFFPGGNIGKLAICGTANDVAVSGAIPRYLSCGFILEEGLPMETLKAVVTSMAETARAAGIAIVTGDTKVVQRGAVDKLFINTAGMGAIPANIHWGAQTLTAGDVLLVSGTLGDHGATILNLREQLGLDGELVSDCAVLTPLIQTLRDIPGVKALRDATRGGVNAVVHEFAAACGCGIELSEAALPVKPAVRGVCELLGLDALNFANEGKLVIAVERNAAEQVLAALHSHPLGKDAALIGEVVERKGVRLAGLYGVKRTLDLPHAEPLPRIC
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Sequence:
MADEEPVDPKREIEESICKPKCVKPLLDYQACVKRIKDDESGHKHCTGQYFDYWSCIDKCVAPRLFAKLK
The following text describes a protein:
Function:
Co-chaperone that binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). Stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. Involved in only a subset of Hsp90 functions.
Miscellaneous:
MISCELLANEOUS: Present with 672 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSVNANGGYTKPQKYVPGPGDPELPPQLSEFKDKTSDEILKEMNRMPFFMTKLDETDGAGGENVELEALKALAYEGEPHEIAENFKKQGNELYKAKRFKDARELYSKGLAVECEDKSINESLYANRAACELELKNYRRCIEDCSKALTINPKNVKCYYRTSKAFFQLNKLEEAKSAATFANQRIDPENKSILNMLSVIDRKEQELKAKEEKQQREAQERENKKIMLESAMTLRNITNIKTHSPVELLNEGKIRLEDPMDFESQLIYPALIMYPTQDEFDFVGEVSELTTVQELVDLVLEGPQERFKKEGKENFTPKKVLVFMETKAGGLIKAGKKLTFHDILKKESPDVPLFDNALKIYIVPKVESEGWISKWDKQKALERRSV
The following text describes a protein:
Function:
Component of the large ribosomal subunit.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm. Rough endoplasmic reticulum. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Sequence:
MGKIMKPGKVVLVLRGKYAGRKAVVVKQQDEGVSDRTYPHAIIAGIDRYPLKVTKDMGKKKIEKRNKLKPFLKVVSYTHLLPTRYSVDVAFDKTNINKEALKAPSKKRKALVEVKSKFEERYKTGKNKWFFTKLRF
The following text describes a protein:
Function:
Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex.
Sequence:
MSAHMSGLEIMDEDQLIKDVLDKFLNCHEQTYDEEFLNTFTHLSQEDHVSKRGVFGTDSSENIFTSAKVTHKNEADDYHLRNKTIFLRTSSQCLEEQVDNFLDLEDLDMDEEIKPQMSEDLLLLPGEVEQDVSTSIPSCIPFVAQPPTCEVKPKPSVKRMDKQTEEILGDEVQLFSLDEEFDYDNVMLTSKFSPAEIENIKELCKQQKRKDTSPDLEKSCD
The following text describes a protein:
Function:
Positive regulator of brassinosteroid signaling.
Subcellular Localization:
Nucleus.
Sequence:
MPKRVAKLAAMDPNEWESSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSFHLLMADHDFPSSFPLEDPNLELMASHFSSSIPNFTHFLPFSTTNTEIFSQFPPNFPENNATSFTTSPVLPSHSVFPPAPTPSVSTTTHHHFHDINNKRKSMPMDVSESTSGISTPQVSESGFNTKYSSGKGKRLKSLEKEEEKSTREVVHVRARRGQATDSHSLAERVRRGKINERLRCLKDIVPGCYKTMGMAVMLDEIINYVQSLQNQVEFLSMKLAAASSFYDFNSEADAISKLQRAKAHEAKELERLMKEGYGGIACFHSNLPL
The following text describes a protein:
Function:
SNARE required for targeting and fusion of ER-derived transport vesicles with the Golgi complex.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Sequence:
MSSRFAGGNAYQRDTGRTQLFGPADGSNSLDDNVSSALGSTDKLDYSQSTLASLESQSEEQMGAMGQRIKALKSLSLKMGDEIRGSNQTIDQLGDTFHNTSVKLKRTFGNMMEMARRSGISIKTWLIIFFMVGVLFFWVWIT
The following text describes a protein:
Function:
Involved in a nickel transport system, probably represents the nickel binder.
Subcellular Localization:
Periplasm.
Sequence:
MLSTLRRTLFALLACASFIVHAAAPDEITTAWPVNVGPLNPHLYTPNQMFAQSMVYEPLVKYQADGSVIPWLAKSWTHSEDGKTWTFTLRDDVKFSNGEPFDAEAAAENFRAVLDNRQRHAWLELANQIVDVKALSKTELQITLKSAYYPFLQELALPRPFRFIAPSQFKNHETMNGIKAPIGTGPWILQESKLNQYDVFVRNENYWGEKPAIKKITFNVIPDPTTRAVAFETGDIDLLYGNEGLLPLDTFARFSQNPAYHTQLSQPIETVMLALNTAKAPTNELAVREALNYAVNKKSLIDNALYGTQQVADTLFAPSVPYANLGLKPSQYDPQKAKALLEKAGWTLPAGKDIREKNGQPLRIELSFIGTDALSKSMAEIIQADMRQIGADVSLIGEEESSIYARQRDGRFGMIFHRTWGAPYDPHAFLSSMRVPSHADFQAQQGLADKPLIDKEIGEVLATHDETQRQALYRDILTRLHDEAVYLPISYISMMVVSKPELGNIPYAPIATEIPFEQIKPVKP
The following text describes a protein:
Function:
Methylates caffeoyl-CoA to feruloyl-CoA and 5-hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers.
Sequence:
MCWVQPANEGSYDFAFIDADKENYVNYHEKLIKLVKIGGLLVYDNTLWGGRVSWPEDKVPPHFRPGRDAAIEFNKTITNDSRVEFALTSVGDGLNICRRIA
The following text describes a protein:
Function:
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Subcellular Localization:
Nucleus.
Sequence:
MPSGGDQSPPPPPPPPAAAASDEEEEDDGEAEDAAPPAESPTPQIQQRFDELCSRLNMDEAARAEAWDSYRSMSESYTLEGNDLHWLACALYVACRKSVPTVSKGTVEGNYVSLTRILKCSEQSLIEFFNKMKKWEDMANLPPHFRERTERLERNFTVSAVIFKKYEPIFQDIFKYPQEEQPRQQRGRKQRRQPCTVSEIFHFCWVLFIYAKGNFPMISDDLVNSYHLLLCALDLVYGNALQCSNRKELVNPNFKGLSEDFHAKDSKPSSDPPCIIEKLCSLHDGLVLEAKGIKEHFWKPYIRKLYEKKLLKGKEENLTGFLEPGNFGESFKAINKAYEEYVLSVGNLDERIFLGEDAEEEIGTLSRCLNAGSGTETAERVQMKNILQQHFDKSKALRISTPLTGVRYIKENSPCVTPVSTATHSLSRLHTMLTGLRNAPSEKLEQILRTCSRDPTQAIANRLKEMFEIYSQHFQPDEDFSNCAKEIASKHFRFAEMLYYKVLESVIEQEQKRLGDMDLSGILEQDAFHRSLLACCLEVVTFSYKPPGNFPFITEIFDVPLYHFYKVIEVFIRAEDGLCREVVKHLNQIEEQILDHLAWKPESPLWEKIRDNENRVPTCEEVMPPQNLERADEICIAGSPLTPRRVTEVRADTGGLGRSITSPTTLYDRYSSPPASTTRRRLFVENDSPSDGGTPGRMPPQPLVNAVPVQNVSGETVSVTPVPGQTLVTMATATVTANNGQTVTIPVQGIANENGGITFFPVQVNVGGQAQAVTGSIQPLSAQALAGSLSSQQVTGTTLQVPGQVAIQQISPGGQQQKQGQSVTSSSNRPRKTSSLSLFFRKVYHLAAVRLRDLCAKLDISDELRKKIWTCFEFSIIQCPELMMDRHLDQLLMCAIYVMAKVTKEDKSFQNIMRCYRTQPQARSQVYRSVLIKGKRKRRNSGSSDSRSHQNSPTELNKDRTSRDSSPVMRSSSTLPVPQPSSAPPTPTRLTGANSDMEEEERGDLIQFYNNIYIKQIKTFAMKYSQANMDAPPLSPYPFVRTGSPRRIQLSQNHPVYISPHKNETMLSPREKIFYYFSNSPSKRLREINSMIRTGETPTKKRGILLEDGSESPAKRICPENHSALLRRLQDVANDRGSH
The following text describes a protein:
Function:
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Sequence:
MKSPGAAEGRRLVGLLEEALVREARLWKVPVFRNGSIQGADISFSQHQQMILWLGEISRLFQFCPETFALGVCILNRLLSAVKAQPKYLKCIAFTSLVLAAKINEEDEVIGSVKDLVERSGCNFSTAEILRMERIILDKLHWDLYTATPVDFIHIFHALLVSGHPHLIPSIGLSPVVDSSPDPAALNCGSGHQKMPPGLQVALWTRQVQHCMACHQLWQFKGSTLALAIITLELEALTPDWFSVFTDLLKKAQVDSAEFIHCKEMVDEYLHSLDFSLPTNAVYIFDGAHIREQHQQRAWRPSRRLRMARRGRGGSQQGDLDEYYDGLRRLYNEETNPEEDGDNVKALFAPQKAVSPCPPLHPAVN
The following text describes a protein:
Function:
Exhibits lipoxin synthase activity as part of a bacterial evasion strategy to suppress the host immune defense. Oxygenates polyenoic fatty acids including eicosatrienoate and docosahexaenoate to the corresponding (n-6)S-hydroperoxy derivatives. In turn, this production of bioactive lipid mediators promotes bacterial persistence in host lung tissues by inhibiting the expression of major chemokines and recruitment of leukocytes.
Subcellular Localization:
Periplasm. Secreted. Note=Periplasmic with some activity further secreted to the extracellular milieu.
Sequence:
MKRRSVLLSGVALSGTALANDSIFFSPLKYLGAEQQRSIDASRSLLDNLIPPSLPQYDNLAGKLARRAVLTSKKLVYVWTENFGNVKGVPMARSVPLGELPNVDWLLKTAGVIVELIVNFVASLPASAAAQFERIATGLSGDLEAARQVHEALLEEAKNDPAAAGSLLLRFTELQTRVIAILTRVGLLVDDILKSASNLVTQRGQGDGLNRFRAVFGTLRLPEVADSFRDDEAFAYWRVAGPNPLLIRRVDALPANFPLGEEQFRRVMGADDSLLEAAASRRLYLLDYAELGKLAPSGAVDKLLTGTGFAYAPIALFALGKDRARLLPVAIQCGQDPATHPMFVRPAESESDLYWGWQMAKTVVQVAEENYHEMFVHLAQTHLVSEAFCLATQRTLAPSHPLHVLLAPHFEGTLFINEGAARILLPSAGFIDVMFAAPIQDTQATAGGNRLGFDFYRGMLPESLKARNVDDPLALPDYPYRDDGLLVWNAIRQWAADYVAVYYASDGDVTADVELAAWVGEVIGSGKVAGFRPITGRSQLVEVLTMVIFTASAQHAAVNFPQPSMMTYAPAICAMSAAPAPDSPSGKSEADWLKMMPPTLVALEKVNIYHLLGSVYHGRLGDYRQTGFPYAPVFSDRRVTASGGPLERFQARLKEVEATIRTRNQARRRPYEYLLPSRIPASTNI
The following text describes a protein:
Function:
Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Theses interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediates inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity).
Miscellaneous:
MISCELLANEOUS: Knockout mice display alterations of the extracellular matrix, and decreased axonal conduction velocities in the CNS.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Domain:
The EGF-like domains mediate interaction with CNTN1. The fibronectin type-III domains 3-5 mediate interaction with BCAN. The fibronectin type-III domains 1-2 and 7-9 mediate interaction with SCN2B (By similarity).
Sequence:
MGIDGETVVLKNMLIGVNLILLGSMLKPSECRLEVTTERAQRQTVEEEGGASSYNTSSKEQPMVFNHVYNINVPLESLCSSGLEASAEQDMSAEDDTLAEYIGQTSDHESQVTFTHKINLPKKACPCASSSQVLQELLSRIEMLEREVSLLRDQCNTNCCQESAATGQLDYVPHCSGHGNFSFESCGCICNEGWFGKNCSEPYCPLGCSSRGVCVDGQCICDSEYSGDDCSELRCPTDCSSRGLCVDGECVCEEPYTGEDCRELRCPGDCSGKGQCANGTCLCQEGYAGEDCSQRRCLNACSGRGHCQEGLCICEEGYQGPDCSAVAPPEDLRVAGISDRSIELEWDGPMAVTEYVISYQPTALGGLQLQQRVPGDWSGVTIMELEPGLTYNISVYAVISNILSLPITAKVATHLSTPQGLQFKTITETTVEVQWEPFSFSFDGWEISFIPKNNEGGVIAQLPSDVTSFNQTGLKPGEEYIVNVVALKEQARSPPTSASVSTVIDGPTQILVRDVSDTVAFVEWTPPRAKVDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTNESEASSTQFTTEIDAPKNLRVGSRTATSLDLEWDNSEAEAQEYKVVYSTLAGEQYHEVLVPKGIGPTTKTTLTDLVPGTEYGVGISAVMNSKQSIPATMNARTELDSPRDLMVTASSETSISLIWTKASGPIDHYRITFTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITAERGRQQSLESTVDAFTGFRPISHLHFSHVTSSSVNITWSDPSPPADRLILNYSPRDKEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTVTSEPIVGSITTGIDPPKNITISNVTKDSLTVSWSSPVAPFDYYRVSYRPTQVGRLDSSVVPNTVTEFAITRLYPATEYEISLNSVRGREESERICTLVHTAMDSPMDLIATNITPTEALLQWKAPMGEVENYVIVLTHFAIAGETILVDGVSEEFQLVDLLPSTHYTVTMYATSGPLMSGTIATNFSTLLDPPDNLTASEVTRQSALISWQPPRAAIENYVLTYKSTDGSRKELIVDAEDTWIRLEGLSENTDYTVLLQAAQEATRSSLTSTVFTTGGRVFSHPQDCAQHLMNGDTLSGVYTIFLNGELSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLDNIHRITAQGRYELRVDMRDGQEAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAMSYKGAWWYKNCHRTNLNGKYGESRHSQGINWYHWKGHEFSIPFVEMKMRPYIHRLTAGRKRRALKF
The following text describes a protein:
Function:
Member of the two-component regulatory system GlrR/GlrK that up-regulates transcription of the glmY sRNA when cells enter the stationary growth phase. Activates GlrR by phosphorylation.
Miscellaneous:
MISCELLANEOUS: Not required for the regulation of the glmY-glmZ-glmS regulatory cascade by glucosamine-6-phosphate depletion.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKRWPVFPRSLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAALVNRTTLIDARRSEAMTNAALEMERSYRQYCVLDDPTLAKVYQSQRKRYSEMLDAHAGVLPDDKLYQALRQDLHNLAQLQCNNSGPDAAAAARLEAFASANTEMVQATRTVVFSRGQQLQREIAERGQYFGWQSLVLFLVSLVMVLLFTRMIIGPVKNIERMINRLGEGRSLGNSVSFSGPSELRSVGQRILWLSERLSWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVSILDSSSRNLQKLIEQLLDYNRKQADSAVELENVELAPLVETVVSAHSLPARAKMMHTDVDLKATACLAEPMLLMSVLDNLYSNAVHYGAESGNICLRSSLHGARVYIDVINTGTPIPQEERAMIFEPFFQGSHQRKGAVKGSGLGLSIARDCIRRMQGELYLVDESGQDVCFRIELPSSKNTK
The following text describes a protein:
Function:
Involved in negative regulation of abscisic acid response in seed germination; Involved in resistance response to the pathogenic bacteria Pseudomonas syringae.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MGTQRSMFIVSFLFKLFLFLSVHVRAQRTTTNFAFRGFNGNQSKIRIEGAAMIKPDGLLRLTDRKSNVTGTAFYHKPVRLLNRNSTNVTIRSFSTSFVFVIIPSSSSNKGFGFTFTLSPTPYRLNAGSAQYLGVFNKENNGDPRNHVFAVEFDTVQGSRDDNTDRIGNDIGLNYNSRTSDLQEPVVYYNNDDHNKKEDFQLESGNPIQALLEYDGATQMLNVTVYPARLGFKPTKPLISQHVPKLLEIVQEEMYVGFTASTGKGQSSAHYVMGWSFSSGGERPIADVLILSELPPPPPNKAKKEGLNSQVIVMIVALSAVMLVMLVLLFFFVMYKKRLGQEETLEDWEIDHPRRLRYRDLYVATDGFKKTGIIGTGGFGTVFKGKLPNSDPIAVKKIIPSSRQGVREFVAEIESLGKLRHKNLVNLQGWCKHKNDLLLIYDYIPNGSLDSLLYTVPRRSGAVLSWNARFQIAKGIASGLLYLHEEWEKIVIHRDVKPSNVLIDSKMNPRLGDFGLARLYERGTLSETTALVGTIGYMAPELSRNGNPSSASDVFAFGVLLLEIVCGRKPTDSGTFFLVDWVMELHANGEILSAIDPRLGSGYDGGEARLALAVGLLCCHQKPASRPSMRIVLRYLNGEENVPEIDDEWGYSKSSRSEFGSKLVGYVSSTSITRVSSTSRISQ
The following text describes a protein:
Function:
Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization (By similarity).
Subcellular Localization:
Mitochondrion.
Sequence:
MQSLRAAFRRRTPIFLKPYEFSTNVFGLRCRYYSQVRHNGALTDLEYHRVADDTLDVLNDTFEDLLEEVGKKDYDIQYANGVITLMLGEKGTYVINKQPPAHQIWLSSPVSGPKHYEYSLKSKTWCSTRDEGTLLGILSSEFSKWFSRPIEFKKSEDF
The following text describes a protein:
Function:
Hydrolyzes ribosome-free peptidyl-tRNAs (with 1 or more amino acids incorporated), which drop off the ribosome during protein synthesis, or as a result of ribosome stalling; Catalyzes the release of premature peptidyl moieties from peptidyl-tRNA molecules trapped in stalled 50S ribosomal subunits, and thus maintains levels of free tRNAs and 50S ribosomes.
Subcellular Localization:
Cytoplasm.
Sequence:
MKVVIGLGNPGKKYEKTRHNIGFIAVDNLRKKFNISDEREKFQALVSEKNIDGEKVIFFKPQTFMNLSGNSVIEIINFYKLDPKKDIIVIYDDMDLSFGDIRIREKGSSGGHNGIKSIISHIGEEFIRIKCGIGAKERDAVEHVLGEFNQTEQKDLDEILEKINNCVIEMLSVQNLDRIMQKYNKKKEISK
The following text describes a protein:
Function:
Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy. Required for both micropexophagy and macropexophagy, but not for the cytoplasm to vacuole transport (Cvt) or autophagy pathways. Required for functional micropexophagic apparatus (MIPA) and relocation of ATG11 to the peroxisome-sequestering arms of the vacuole. Binds palmitoyl-CoA but not oleyl-CoA.
Subcellular Localization:
Peroxisome membrane; Single-pass membrane protein. Note=Localization to the peroxisome is ATG30-dependent.
Sequence:
MSESIDRVFVKAIGTIRTLSSRTGYGGLPRPPIENRVKLYGLYKQATEGDVAGVMERPLGDSPEAEAAKRKWDAWRSEQGTSKTEAKRQYISYLIDTMKQFASDTTEARELLSELEYLWNQISDVSPNDSSDSESNAGPAQLLQNHAQLLSRDISVVDDPITSSGMDPMYNPSFQRHNSSRFINASTAERLNSLSNYYSNLNPTPPLSSRRYQGSVTPRNVDFIKWQNDINNSINKLNHDLQLLANRRLQSSASDPLYSKRGSDLTHDDFVNDISSSSSNRRFRARRNQPLVSKVLLGTISLLLKLIKTVIKHVAIDAVIIAVLVAVIKRSIIIPNLISNEISLQKIHHSELESNSSIKGDSNGGRLTIVLPFINGKDFFQENSLLGKLLKVFHDYVDHVSRIRLIKRN
The following text describes a protein:
Function:
Involved in mRNA and protein export from nucleus.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.
Sequence:
MEMYVEDVPMPDIGPDSVLNTPIRPKYEILKSKKKTQNENDPEPMDISMSPDEKNLKKSTVRRKLRKSKPNSSSNQVSSRTRALTKRSNSSNAIIKANNQDSVYVSDWTNVHRDIPIVVSGYLQLMFNACVASIFLYFLFKIVFGIQNDVRNRVEYHKILQEEQAADCQREYLSINCDSPGPAIFEVCQKLKQCKMESSNNVGSTKLAALVFAEIIDAFISHISYKTMVFSLILVFGSLLTSNYAFGLYRARHSQNIHDYAANAIPAMIPSSRFLPSNLSDISNRNLIEAASQEEEI
The following text describes a protein:
Function:
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families. Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus.
Sequence:
MRTLTLDRQGGRKAKALACLCVRSAAPEALLPGVRRAGTVCARHAPADMAAEAPRSQAVPGPGRLLLLLAAASVPLARAQGDEFRPGQWGAAAAGGGATAAAQGRRYLLYDVNPPEGFNLRRDVYIRVASLLKTLLRTEPWVLVLPPWGRLYHWQSPDIRQVRIPWADFFDLPSLGKNIPVLEYEQFMAESGGPFIEQVYVLQGYAEGWKEGTWEEKVDERPCIDQLLYSRDKHDYYRGWFWGYEETRGLRVSCLSVQGSASVIAPVLLRNTSARSVMLDRAENLLHDHYGGKEYWDTRRSMVFAQHLRAVGDDFRSKYLNSTDEADKMPFAEDWTQMKVKLGTSLGGPYLGVHLRRKDFIWGHREDVPSLQGAVKTIRSLMETHKLTRVFVATDAVRKEAEELKRLLPEMVRFEPTWEELELYKDGGVAIIDQWICTHARMEASSFGASPAFGFVSDLCSVDAGSGLKGPWSFWGTERTFQMEKQPTLGHRALDGEAAYLGTQSTGLGA