lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIGLKKHRAFLERLRWTLRAQHVFGVSSLIVDKRGNVRSGSAAPKFILAMLGLAISLAVWFILYHNESPVICRSKANQVRLFYYFVIIETLVAIAFNVICTIRIAWPASQHSLAQCWAQLIAKVQEIQIMFQCSIESKRPFQLFWLWIAVLSAAYGFLLTFMVLTSKVLFVSQTNHLILYGLRIYAYLSDTTVCASFGLFALLLRILIVEMRQLVRKTTINEQQLRSMIQLYRHILQIIESFCAVYGWVLILIFFEHFLILTDRSFFAIRMYRMPMGFSIQQVLSMMMTWVFPLALNDMLLVGACTATEKALQQFEQQLCEVGKMANTQNVECEQMITSFSLYVAEQKPKFRILKSINLSFNLIYASCGVIATYLTVFLQFDNGDSL
The following text describes a protein:
Function:
Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MNQSDGFATESSLNTAVVYTFKETCRLYKKKLKRLKHLHLNRLQQIRFDLDLKLGRDKKWQSSMSNNKSTELQHQHVNSGLKLKVKLDSQTSPSFLSINSRKLQEKPGIRRILLKRLLEQNLSGSNNNNNNNINNNDDNKNNNINNIKLSQLTCHYRKGFQCNELCLPLSIYCLKHILNDDKQVLYTKCLGDNTCTTPVLDISVVQACPQHFRDVLISELCQPTELRRPPHNCPQQNRDVPVSGSGSSRHFSDVLISRSSGLIIKEDGEAGTGDIKMEISEENEKVLDADVKEENNYIENT
The following text describes a protein:
Function:
Acts as a co-chaperone for HSP90.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSNFSKISHPEVLWAQRADKVYLTLALTNAKDISVKCEPQGSFNFSAVGPKDENVDFSLELYGKILPESCKTQMGLRNILCTVQKEEKGWWKRLLKSEAKPAPYIKVDWNRWCDEDEEPDNGTDDDDLKYTSDDDGSGSDDGMLYLPDLEKAIK
The following text describes a protein:
Function:
Methylates ribosomal protein L11.
Subcellular Localization:
Cytoplasm.
Sequence:
METWQELKVTVKREGEELVSNLLIELGAQGVAIEDSMDYMGNVDRFGEIFPEVEQQEEIVVTAYYPDTVDVTVVEADLQARLAELTDFMDLGEVKMGTTALAEEDWADNWKKYYEPARITHDLTIVPSWTDYEATAGEKIIKLDPGMAFGTGTHPTTKMSLFALEQVLRGGETVLDVGTGSGVLSIASSLLGAKEIFAYDLDDVAVRVAQENIELNPGMENIHVAAGDLLKGVEIEADVIVANILADILIHLTDDAYRLVKDEGYLIMSGIIKDKWDMVRESAESAGFFLETHMVQGEWNACVFKKTKDISGVIGG
The following text describes a protein:
Function:
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex.
Subcellular Localization:
Nucleus.
Sequence:
MHRAVDPPGARAAREAFALGGLSCAGAWSSCPPHPPPRSAWLPGGRCSASIGQPPLPAPLPPSHGSSSGHPNKPYYAPGAPTPRPLHGKLESLHGCVQALLREPAQPGLWEQLGQLYESEHDSEEATRCYHSALRYGGSFAELGPRIGRLQQAQLWNFHTGSCQHRAKVLPPLEQVWNLLHLEHKRNYGAKRGGPPVKRAAEPPVVQPVPPAALSGPSGEEGLSPGGKRRRGCNSEQTGLPPGLPLPPPPLPPPPPPPPPPPPPPPPLPGLATSPPFQLTKPGLWSTLHGDAWGPERKGSAPPERQEQRHSLPHPYPYPAPVYTAHPPGHRLVPAAPPGPGPRPPGAESHGCLPATRPPGSDLRESRVQRSRMDSSVSPAATTACVPYAPSRPPGLPGTTTSSSSSSSSNTGLRGVEPNPGIPGADHYQTPALEVSHHGRLGPSAHSSRKPFLGAPAATPHLSLPTGFSXXXXXXXXXXXXXXXXXXXXXXXXXXXRAAREDGEILEELFFGTEGPPRPAPPPLPHREGFLGPPASRFSVGTQDSHTPPTPPTPTPTTSSSNSNSGSHSSSPAGPVSFPPPPYLARSIDPLPRPPSPAQNPQDPPLVPLTLALPPAPPSSCHQNTSGSFRRPESPRPRVSFPKTPEVGPGPPPGPLSKAPQPVPPGVGELPARGTRLFDFPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQHEAGVAPPPPLKEPFASLQSPFPTNTAPTTTAPAVAVTTTTTTTTTATQEEEKKPPPALPPPPPLAKFPPPPQPQPPPPPPPSPASLLKSLASVLEGQKYCYRGTGAAVSTRPGPLPTTQYSPGPPSGATAPPPTSVAPSAQGSPQPSASSSSQFSTSGGPWARERRAGEEPVPGPMTPTQPPPPLSLPPARSESEVLEEISRACETLVERVGRSATDPADPVDTAEPADSGTERLLPPAQAKEEAGGVAAVSGSCKRRQKEHQKEHRRHRRACKDGVGRRPREGRAKAKAKAPKEKSRRVLGNLDLQSEEIQGREKSRPDLGGASKAKPPTAPAPPSAPAPSAQPTPPSASVPGKKAREEAPGPPGVSRADMLKLRSLSEGPPKELKIRLIKVESGDKETFIASEVEERRLRMADLTISHCAADVVRASKNAKVKGKFRESYLSPAQSVKPKINTEEKLPREKLNPPTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESLQEEKESEDEESEEPDSTTGTPPSSAPDPKNHHIIKFGTNIDLSDAKRWKPQLQELLKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDRHGVDYLTGSWWPILDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNVGPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKFCLLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYCNECDVEVFNILFVTSENGSRNTYLVHCEGCARRRSAGLQGVVVLEQYRTEELAQAYDAFTLVRARRARGQRRRALGQAAGTGFGSPAAPFPEPPPAFSPQAPASTSR
The following text describes a protein:
Function:
Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MDFIDFDTFTKDASGSDNDVFPQPQPPLSLPIASNLDQFSKKLSNLVLPGNILNNDNTKPSNEISEVDNVMEKYAKMSIDLIKRETGDVQLENEEDSKESSVRTSLSTRLSRVLNDSLSDATIREIFSNLQERFDKESNGYVVDLIESGIVGSMSRKKFKGRIESELIRNQSNILKQYQPIVKQLKQIEVKLNKLNELSVQTNDKINKNFDFSNKLNLEIKDLNDNKRLIGLKKNLLISFKEKFTLNEYEEFVLNSGDLNNEFFTTLARAERINENCSILLSLDNPQLGLKIIAKSNQMINRSIDRIVSYTNKTLGNMYSLSSKSRLATLHQCFKYLQNKLNYFNSIVNTFSESRSKVLVDEFNRQVQGDFEVNGQGRSSSISSDSRPIYMSAHDPVRFVGDLLAYVHSVSVNESETITSIFTMGDDNDKEFENIIQDVTDKILQSLSRPIKARVEQIVSTETKLSTLVQIFNLVELYNIMFTKQLGKAGNIVETVKQLIKVCQGRIFMIISNRLATIKNKNSTKLDLNLDLQPPEWIIEFYSDILPIVDQITTETILNLSPEENEKFLNLIVNEPIQVFNEHVDHNKVFSEKKDVLIIKSNFLDLILSKTIPVSLLSEKVLEVNEMIDKLTEEITQLELNNMLGQCGLYDYFNIINMICPFSDDFFEVSIYEPIKENKLYTKDSFVQVDEKVQEFFPSAMIEMQQSLLKLNSPIVVNQIIDNSFMQFVKFYCKLDLINKEYLDFSFTWSDMEIATLVGIEDVYSKDISIM
The following text describes a protein:
Function:
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.
Subcellular Localization:
Cell membrane.
Sequence:
METLLKVLSGTLLWQLTWVRSQQPVQSPQAVILREGEDAVINCSSSKALYSVHWYRQKHGEAPVFLMILLKGGEQKGHDKISASFNEKKQQSSLYLTASQLSYSGTYFCGTE
The following text describes a protein:
Function:
GTPase component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. The Dom34-Hbs1 complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Pelota-HBS1L complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. The Dom34-Hbs1 complex is also involved in non-functional rRNA decay.
Miscellaneous:
MISCELLANEOUS: Present with 2750 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MAYSDYSDGADDMPDFHDEGEFDDYLNDDEYDLMNEVFPTLKAQLQDYQGWDNLSLKLALFDNNFDLESTLAELKKTLKKKKTPKKPIAAANGSANVTQKLANISISQQRPNDRLPDWLDEEESEGERNGEEANDEKTVQRYYKTTVPTKPKKPHDISAFVKSALPHLSFVVLGHVDAGKSTLMGRLLYDLNIVNQSQLRKLQRESETMGKSSFKFAWIMDQTNEERERGVTVSICTSHFSTHRANFTIVDAPGHRDFVPNAIMGISQADMAILCVDCSTNAFESGFDLDGQTKEHMLLASSLGIHNLIIAMNKMDNVDWSQQRFEEIKSKLLPYLVDIGFFEDNINWVPISGFSGEGVYKIEYTDEVRQWYNGPNLMSTLENAAFKISKENEGINKDDPFLFSVLEIIPSKKTSNDLALVSGKLESGSIQPGESLTIYPSEQSCIVDKIQVGSQQGQSTNHEETDVAIKGDFVTLKLRKAYPEDIQNGDLAASVDYSSIHSAQCFVLELTTFDMNRPLLPGTPFILFIGVKEQPARIKRLISFIDKGNTASKKKIRHLGSKQRAFVEIELIEVKRWIPLLTAHENDRLGRVVLRKDGRTIAAGKISEITQ
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MVDQRILFCEECSNNVFGILYYLLYKNVKSPNNNSRQLSKPKIMSIQATKFSIPSHSKEIDMDIEQEEFINEPLLQTKCNQLGMLNQREHSRTTENNFTFEPFDQPSLTQVPPDHMQSHLSLMEECFTSLLESTIPDEILCRDQEKVLITRFIEDGIKNNGQKQALYISGVPGIGKTATVLEVKNKLHFKKLDFDFIYFNAMNIRAPEDIYPFLYEKITNKKETSRIKSCILLTELFNSEQDCIQKNKVILLDECDNLYTSDQQVLYNLVDWPQQRYAHLIVIMIANTMDFPERLKPKLQSRLGNHRIVFRPYNSTQIESILQQRMKTSKLKQLFASNTLNYLGKKIATISTDIRKTLSVCRTAIVLAREQLLRRNTFSQIEVDHIKLAYNIIYNKPQHNALQYFNAELKLLLIMIAIDIHVKGQNYACFHQVVQRMNQQQSLHNKKPLSYYQIKQALIKLSQMNLIEIKEEQILLTKSTWQQKIQNSLDQDRLFNLEDILIQLKINIDDIKNGLSKDDLFNEFSNLF
The following text describes a protein:
Function:
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAALNYARPIELNPAGEHKSTMIMLHGLGDTGDGWSDIGYMYKSSLPNTKFIFPHAPRRPITINFGMSMPGWYDIASLEEVNRSEDAEGLQESKRYIEELIAKEVAAGIPASKIVLGGFSQGGAVALMMLRSATQLGAVVALSAYVPLHTQQPVFSEANAKTPILMCHGDADQTVAFAFGQKSYQLLQSLGANVEFQAYVGMGHSACQREFDDVLEFVKPVLAA
The following text describes a protein:
Function:
Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling. Plays an important role during spermatogenesis by modulating the assembly and elongation of the sperm flagella.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MNTSDIREIVAHLNEPPFSMGLNLISFDNFTKDKLLQTLSDVLCYINDSPKIDIRSEPADQTAIRIMNALKIFKFKPPTDIEQLDEWRAGVVEGSPAAIHPVLFYLFENVDQLKTRAYLARFLVRVEVPQEMQDSDLHQMQEEVNELMDQFKEVHSRTQEISGESEHIEVLKNDLKTMESEKDQITRRIERIEQRVKNIPNVDKIVEFAARKRGESERIKEMEDRKTEIRQDMMKSEKKMQRRATDLAELQRAAEVIDPSGLIKELEAEIQTNSYLANGKLAREIEEQRPKIGVLSSLVQGPAVDEASIERLQKEIEEKTESNNRMKEERNLKEEDHDENFLMYRHQTKAVENKKDNAAQRLQEARQELEHIEAQIQEKKRELRDRTGEEEVVTTVQFRNYVSKMRIKTNEYKKKRKELDHMQNEINVLNRTSQIISAQWNQLKGKISDMGGEVMDVTIEIPSMTRPKTAAPKTNDIEELKAMIKQLNVEVSRKSDQLAPLRKEHQEKTDEFNTLMDTLREKKRDYDRKKAALQTGFEETKREVEDLENRKVKTEEKMKTAEEKLEMARVQKDRVDRERRGEEKPYVQELQERIQQAQEEQEVLQSHGGEQMNFEMARKQKAMWTGMQILFEAKMKAMKERDSSQPIGDRIARLS
The following text describes a protein:
Function:
Involved in the biosynthesis of carotenoids spheroidene and spirilloxanthin. Catalyzes the hydration of neurosporene to the corresponding hydroxylated carotenoids 1-HO-neurosporene and 1,1'-(HO)2-neurosporene and that of lycopene to 1-HO-lycopene and 1,1'-(HO)2-lycopene. Can also act on demethylspheroidene, spheroidene, 1-HO-3,4-didehydrolycopene and geranylgeraniol.
Subcellular Localization:
Cell membrane.
Sequence:
MRAAESGADARVRPVDRVEPADAPAGDAGGLRAAVPGDGGSAVRPGDARLDVLVPPGLVDEPAAGALPGGGQRAPGAGRADGGDVRPVGGRDADGAPRFDQPVPPGGYLWWYVDAVSDDGRHGLTFIAFVGSVFSPYYAWAGGPKADRADPENHCALNIALYGDAGKRWTMTERGRRWMRRSRDEFVIGPSRLHWDGESLLVEFDEVGVPIPRRVKGRVRVWPKALCRFVTSLDSGGRHRWGPIAPCSRIEVELDSPRVRWSGHAYLDSNEGDEPIDRPFREWDWSRATMADSSTAVIYDVRQKRDGDRVIAERFLLDGSTESFEAPPRQPLPTTLWRIGRTMRTEPGVPALVEQTLEDTPFYARSMVRSGLLGEVVTSVHETMLLPRVITLPVRLMLPWRMPRRA
The following text describes a protein:
Function:
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
Sequence:
MKDKFGREIRSLRISITNKCNLQCFYCHREGHDSNNDRYMTPEEIGIIAKTSTKFGVKKIKISGGEPLLRKDVCEIIENIKDERIKDISLTTNGILLENLAEKLKDAGLNRVNVSLDTLNPELYKKITKFGDVERVINGIKKAIDVSLTPLKVNFLAMSINIKDLPDIMEFCRDIGAILQIIEFIPLKEELKGYYYNISPIENEIKEKADKVITRNFMQNRKKYIVDGLEIEFVRPMDNSEFCMHCTRIRLTYDGYLKPCLLRDDNLVDVLTPLRKGENLEPYFIECINRREPYFKIK
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
Sequence:
MAILRANLSPKNKLNATLKGWLPILQSELEDLEEVLKQNALDNPLIKIENKRIKNFSDRFSAKKSSDHLENFATASKSLFETLEAQIIPPLFPTETSQKIAMDIISGLNNEGYFEENIEERARILGVESEVYEKVRKRFSYLNPAGIGAKDVKESFLFQLESRELDDNELYEETRKIILNLEKHHEFSKDFYYEKALKILKSFKNPPAIEFLEKEIEVIPELFIVEVDNGIIVRLNDESYPTISLEENRFKDSGYLKEKLKEAKDLIDALNLRKATIYKIGLMLLEYQYDFFKGKELRPLKLLDLANEFNHSVSTISRAISNKYLACERGVFPIKHFFSIALDNSETSNAVIKDYLLELIKNEDKKEPLSDAKILELIEEKFHLKMVRRTITKYRQLLNIASSSERKRLYLMRA
The following text describes a protein:
Function:
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
Subcellular Localization:
Cytoplasm.
Domain:
Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
Sequence:
MLFSKLFAPTLKEPPKDAVLKSHKHLAQAGYIYQVGSGIYNFLPLAKKVLDKIENITHKRMQEHGAQNILMSFVVLASLWEKSGRLDKYGKELLVFKDRKDNDFVLSPTLEENITEIAANFIKSYKQLPVHLYQIHTKFRDEIRPRFGLVRAREFIMKDGYSFHEDAESLDKEFLNTQSAYKEILSDLGLDFRIVEADSGAIGGSKSREFVVLTECGEDTIVVCQNCDYAANIEIAKRSKRPEPLNVPKAQLAKFPTPNTTSAQSVAEFFKTEPYFVLKALVRKVIHKDKETLACFFVRGDDNLEEVKALNALNIIGANALELREASQKDLDNVGLIAGFIGPYGLKKHVSYIIFDEDLKEGDCLIAGANEKDFHAVGVDLKGFENLVYADIVQVKESDRCPNCQGALKYHKSLEVGHIFKLGQGYAKSLKASFLDKNGKEQFFEMGCYGIGISRLLSAILEQKSDDLGCVWTKNTAPFDVVIVVSNWKDEAQKKLAFEVYERLLQKGVDALLDDRDARFGAKMRDFELIGERLALIIGKQTLESKEFECIKRANLEKQTIKDIELEEKILEMLESE
The following text describes a protein:
Function:
Required for sorting and processing of soluble vacuolar proteins, integrity of vacuolar morphology, efficient segregation of vacuolar material into the bud during the cell cycle, acidification of the vacuolar lumen, and assembly of the vacuolar H(+)-ATPase.
Miscellaneous:
MISCELLANEOUS: Present with 2270 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MVKKKTNNDKGKEVKENEGKLDIDSESSPHERENDKKKTEDDSLRATESEETNTHNANPNETVRADKFSQEESRPIEDSPHTDKNTAQESCQPSSAEDNVINTDITSLNEKTSTNDEQEKGLPLKISEGPFTISTLLDNVPSDLIYTCCEAYENHIFLGTTTGDLLHYFELERGNYMLVSQTKFDAESNSKIDKILLLPKVEGALILCDNELVLFILPEFAPRPNTTRLKGISDVVICNFSRSSKAYRIYAFHAEGVRLLKISADSLVLTKAFNFKLIDKACAHEETLMVSKLNSYELINLKSSQVIPLFRISETDEDLEPIITSFNEQSEFLVCSGGGSYDSGAMALVVNHHGDIIKGTIVLKNYPRNVIVEFPYIIAESAFQSVDIYSALPSEKSQLLQSITTSGSDLKISKSDNVFTNTNNSEEFKEKIFNKLRLEPLTHSDNKFRIERERAFVEESYEEKTSLIVYNNLGIHLLVPTPMVLRFTSCEESEIDNIEDQLKKLAKKDLTKFEHIEAKYLMSLLLFLMTLHYDHIEDEVMKKWCDFSDKVDIRILFYMFGWKVYSEIWCFHGLINIVERLKSLKLTNKCENILKMLLMMKNELKKKNKTGLLTNDFDDIMKTIDITLFKLRLEKKETITVDMFERESYDEIIREINLHDDKLPRIELLIEIYKEKGEYLKALNLLREAGDYISLVSFIEENLKKLPEDYIKERIADDLLLTLKQGDENTEECAIKKVLKILDMACINKNDFLNKIPAEETSLKVSFIEQLGVQNSNDSKFLFNYYLAKLREIINQSNIWSILGDFIKEYKDDFAYDKTDITNFIHIKLKHSLQCENFSKYYEKCENLKSENEKDDEFINFTFDEISKIDKEHILTLLFFPNELTNWVSSEELLKIYLSFNDFRSVEKYIGKQNLVAVMKQYLDISSLNYSVELVTNLLQRNFELLDDTDIQLKILETIPSVFPVQTISELLLKVLIKYQEKKEESNLRKCLLKNQISISDELSRNFDSQG
The following text describes a protein:
Function:
Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Also acts on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MRMLLNLSLLALGAAYVSAFAVENPMNRLVAETLTLLSTHRTWLIGDGNLMIPTPENKNHQLCIKEVFQGIDTLKNQTAHGEAVDKLFQNLSLIKEHIERQKKRCAGERWRVTKFLDYLQVFLGVINTEWTPES
The following text describes a protein:
Function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
Subcellular Localization:
Mitochondrion.
Sequence:
MNRILKQVSNTKGKGIRFYSSSSQLDSEYMFPSVRRLLVEYGINSSKEVTATGPQNRLLKGDVLAYIKTKNLSPVDRLSLIASSVKSSQPSSSSSPSIVDSPTLTSQIKDQIKIVTTITNDKNKSKVIYEDIPNNNIRRVIATKLSQSKQQVPHFYMTVECELDNVLAMRKSMPENVKISVNDFVLRACALALRDNPQANSKWSDEHGEAILNPTVDISFAVSTDRGLITPIITNTDKKQLLAISNESKQLALKARDGKLKPEEFIGGTFSVSNLGMFGITSFNAIINYPQAGILAIGTGRKVLRPPSTYQPIETNLNASYGSEGKSEIINTNGPLTTEQLEKLFDNTVSKKQDIKQQIINEQPQPPKYEQPKVANVMDVTLSGDNRVFDDEIAGKFLSSFKYYLSNPQNMIL
The following text describes a protein:
Function:
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP-GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1-P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcNAc and pyrophosphate.
Sequence:
MKGVILAAGKGERLRPLTDDRPKVVLKVANRPIIEYVLENLDPFVDEFVIIVRYQKEKLIEVLGDEFNGKPITYVEQLPGDGTAKAIESAREHVGDEEFIVANGDIYFEEEGVRELVAVFRREKADAALLVKHFEDLSHFGKIEVEGSLVKRVTEKPGKVPGYANLGVYIFKPEVFGFIERTPLSERGEYEITDTINLMIEAGKKVAYAAYSGYWNDIGRPWNLLELNEYLLKTKLKHEVRGTVEEGAVLIPPVEIGEGTVIRSGAYIIGPVKIGKNSRIGPNCFIRPYTSIGDNCHVGNAVEVKNSIIMDNSNAPHLNYVGDSIIGENCNLGAGTITANLRHDRGNIKVEIKGKLEDSGRHKLGAIIGHNVKTGINVTIYPGRKIGSGSLIGPGVIVDKNVPPRTLVVVKQEKVVKEL
The following text describes a protein:
Function:
Glycosyletransferase required for the proper composition and structural properties of released seed coat mucilage. Required for the production of highly branched xylan polymers in seed coat mucilage. Facilitates the addition of xylose residues directly to the xylan backbone. Xylan with xylose side chains seems to be necessary for pectin attachment to the seed surface. Essential for xylan synthesis in seed coat epidermal (SCE) cells.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MRQNLKKVAQIKVDESKKLFPYVFRVKTSCGNCAKRSKPKLIYLLIFSLISSCFVFAPQLLCFPYPSALFLIDSSIKEIENRVSESNIESPKTSQKEESISCDRTGYRSDICFMKGDIRTHSPSSSIFLYTSNDLTTDQVLQEKIKPYTRKWETSIMETIPELKLVTKDMKLFGDKRKCEVIHEVPAVLFSTGGYTGNLYHEFNDGLIPLYITSKRFNKKVVFVIAEYHKWWEMKYGDVLSQLSDYSLIDFNKDKRTHCFKEAIVGLRIHGELTVDPSQMQDDGTTINEFRNVLDRAYRPRINRLDRLEEQRFHARLAQRRKAKRPKLALFSRTGSRGITNEDLMVKMAQRIGFDIEVLRPDRTTELAKIYRVLNSSKVMVGVHGAAMTHFLFMKPGSIFIQIIPLGTDWAAETYYGEPAKKLGLDYNGYKILPRESSLYEKYDKDDPILKDPNSITKKGWQFTKGIYLNDQKVRLDLHRFKKLLIDAYAKSIR
The following text describes a protein:
Function:
Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used during anaerobic growth, and succinate dehydrogenase is used during aerobic growth. The QFR enzyme complex binds 2 quinones in or near the membrane; 1 near the [3Fe-4S] cluster (QP is proximal to the [3Fe-4S] cluster, on the cytoplasmic side of the membrane) while QD (the distal cluster) is on the other side of the membrane. It is not clear if both of the quinol-binding sites are functionally relevant.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MAEMKNLKIEVVRYNPEVDTAPHSAFYEVPYDATTSLLDALGYIKDNLAPDLSYRWSCRMAICGSCGMMVNNVPKLACKTFLRDYTDGMKVEALANFPIERDLVVDMTHFIESLEAIKPYIIGNSRTADQGTNIQTPAQMAKYHQFSGCINCGLCYAACPQFGLNPEFIGPAAITLAHRYNEDSRDHGKKERMAQLNSQNGVWSCTFVGYCSEVCPKHVDPAAAIQQGKVESSKDFLIATLKPR
The following text describes a protein:
Function:
Permease involved in cell wall peptidoglycan recycling. Transports, from the periplasm into the cytoplasm, the disaccharide N-acetylglucosaminyl-beta-1,4-anhydro-N-acetylmuramic acid (GlcNAc-anhMurNAc) and GlcNAc-anhMurNAc-peptides. Transport is dependent on the proton motive force. AmpG is also involved in beta-lactamase induction.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
Four hydrophobic segments are not embedded in the cytoplasmic membrane and form two large cytoplasmic loops.
Sequence:
MSSQYLRIFQQPRSAILLILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQAYVFKFLWSPLMDRYTPPFFGRRRGWLLATQILLLVAIAAMGFLEPGTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADKWLGWQGMYWLMAALLIPCIIATLLAPEPTDTIPVPKTLEQAVVAPLRDFFGRNNAWLILLLIVLYKLGDAFAMSLTTTFLIRGVGFDAGEVGVVNKTLGLLATIVGALYGGILMQRLSLFRALLIFGILQGASNAGYWLLSITDKHLYSMGAAVFFENLCGGMGTSAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPVAGWFVEAHGWSTFYLFSVAAAVPGLILLLVCRQTLEYTRVNDNFISRTAYPAGYAFAMWTLAAGVSLLAVWLLLLTMDALDLTHFSFLPALLEVGVLVALSGVVLGGLLDYLALRKTHLT
The following text describes a protein:
Function:
Structural component of the gap junctions.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MLGTFSKLKAAIKLKTTSVKITTPVFALHYRLTFLVLLTCSILVTSRQYIGEHIQCIQDAVAVPVKILNNYCFISSTFSIPRTTPIAKGEISLFGLGPYTEEDDVTYHAYYQWVPFVLFGQALMFYTPYYLWKMWEGTKVRNIIQGMHIFTIKEKIEVRDEKEEILTKYIVRNLHEHNGWAIRFFVCELMNLVNVIGQIFLTNRFLGGEFLRYGIEVVEFLDQDPETRVDPMARVFPRLTKCVFHKYGSSGTIQRHDALCILALNIINEKIYTFLWFWFIILAIITSIDFLVRVVIVMMPPVRMFLLRSRLSAPQKDDADVITQRCSIGDWLLVDFLSKNMDTMVFSNVVGKLAKELEYGRKFPGHVSESTPMMS