lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MAGKSPAAGNAGGGSAAKKAKKAGASDGNSGAKPVAAAKGRPSVGKPAKTAPAKQPSGSGKPAAKGAGPAAAAKPSRKAPAAAAVGAGGPAKKRKRGPAFWDSLPGWEEVEVGEDFLLGAEEGGFAGLEVLDDPAVLEQYMLEGGAGGGGEGSEGGSDGEDGGLSGGSGDGDGDEDWEGFDAHSDKKAEGAAKEEKKEKKGKEAEAEDAEAGDDPAAAAAAAEERKQKQKERAKAKKARRKERRLARLAGGGGVSGSGSEGADEEDEEDGDGGGAKAAAPAAKRQKQDAAAAAAAKKQEAAAQKQAKQEQQKQAKQEQQKQSKEAAKAQKAAAAAAADEDDDDEDEDEDEDVDLEDMDEAALAELLGEDDEEDGGGGEDEGEDEEGDEGEEEQEDEELLAGLLGLESGSGEGEEGEEGEGEEGEEEEDEGMEGLTGSEEPGTDDGGGGGTEDADEAEEDAPQQQQEEEAPDMSAWEEFELAGGVLAGLAALGFANPTPIQRECLGPAIRARADIIGAAQTGSGKTLAFGLPILHVLAAERAEREAARGWEEQEGGEEAGGAAGVSGSEDPFTSEGEDDELGTGSGAGTEEGEEEEAAAAGGGKGGAKGGAKGLSKAEQRRLKARQRMRAKKLAAKKKRAAARQQQQGKGQAQGQQWPKPEPGPLRALILTPTRELAMQVCSHLQAIGRPCGVRVLSIVGGISDVKQARQLAARPAVIVATPGRLWDLMCRPPSTDRYGPLAAAHLADLSRLSFLVLDEADRMVAQGLYKELTSILELLPHPANNKQVTEDAEFAELRQQKEADRAARRAEKEAAAAARKAQQQQGGSEEGEEEEEDEDEEEDAMETDEGAEGEEHSGSGSGAGTEEGEEGEDEEPEAVGDAEGEAEGEAGDQLDQQDQDQDQPKKRKKHLMQTFVFSATLTLPLFLKKRVSKRDRGGGAGGGAATLESLMDRVPFRKSPAPRVVDLTPHSRLADRLTEASISCLDDERDELLYYLLAAHPGRTLVFANAVSAVRRLGALLALLGLPVYALHAQQQQRQRLKALDRFRANPNGVLVATDVAARGLDIPNVSTVVHYQIPPSADTYIHRCGRTARGISCDGIAIALVTPREAARFSGLCRLLERPGPPASFPVDASLLPAVRQRLRLAARLDDIERAERKQRAEAAWRKSNAAAIGLDVSDDEEGGSGSDDDGEGGGRRMRNGRQSQTSAQAAALRQQLSAMLAQPLAPKMSRRYFTGGLAAALATRTKQQPAPGGAAAAKPKSGGPGAAAPSAAVAAVPRAVALASRMAAGQQAAAAAADAAKARQAKRAKKNASKAAAAKGGAGAGAGAGVRAGLAKAKGKAKVDTRLLVSRNQMKKQNHRGMVVIPQAFGRDAAAPNALEALRTRMAALGAGGGATGAAAAFVSAGGKGAGGRGAGGKGGAGGKGGGGGGGAGAGGRKQGKKQSAKGRKAAKGRKGRK
The following text describes a protein:
Function:
Active in the repair of DNA damage and in mating-type switching. Probably involved in the repair of DNA double-strands breaks. Has a role in promoting S phase completion.
Sequence:
MGSLPDQSSCEEFTDSQQDKMTKLLAMQLGPEYISRRSGPGGGSVTYLEAWKAIELANEIFGFNGWSSSIQDIHVDYVEETKEKKFNVGISVIVRVTLKDGSFHEDVGYGSIENCRVKALAYEKCKKEGTTDALKRALRNFGSSMGNCLYDKRYIQKILKMAPAQAEFNYDNLLRANKRPYARFAQKVSTPIESHANKSVKLEHKNSIEKKISNVDKPISDLIENDIHESLPALQNPPIQSHSETDLYADEELDSILMHHERPPIPESPRVEEFEELLNQFEGDEKVSVDKIDAHDKMTEAQVVKIPPVQFMNARVAAAENPHIKHEGMAFQLHKKSNSILKSSNIDHNRSMPIRRPSLTSNNSANTFSTK
The following text describes a protein:
Function:
The main replicative DNA helicase, it participates in initiation and elongation during chromosome replication. Travels ahead of the DNA replisome, separating dsDNA into templates for DNA synthesis. A processive ATP-dependent 5'-3' DNA helicase it has DNA-dependent ATPase activity.
Sequence:
MQFVDKLPCDESAERAVLGSMLEDPENIPLVLEYLKEEDFCIDEHKLLFRVLTNLWSEYGNKLDFVLIKDHLEKKNLLQKIPIDWLEELYEEAVSPDTLEEVCKIVKQRSAQRAIIQLGIELIHKGKENKDFHTLIEEAQSRIFSIAESATSTQFYHVKDVAEEVIELIYKFKSSDRLVTGLPSGFTELDLKTTGFHPGDLIILAARPGMGKTAFMLSIIYNLAKDEGKPSAVFSLEMSKEQLVMRLLSMMSEVPLFKIRSGSISNEDLKKLEASAIELAKYDIYLDDTPALTTTDLRIRARKLRKEKEVEFVAVDYLQLLRPPVRKSSRQEEVAEVSRNLKALAKELHIPVMALAQLSREVEKRSDKRPQLADLRESGQIEQDADLILFLHRPEYYKKKPNPEEQGIAEVIIAKQRQGPTDIVKLAFIKEYTKFANLEALPEQPPEEEELSEIIETQEDEGFEDIDF
The following text describes a protein:
Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes (By similarity). Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Endosome membrane. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or Mycobacterium.
Domain:
Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drives interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.
Sequence:
MLEEDMEVAIKMVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIQVNDEDVRLMLWDTAGQEEFDAITKAYYRGAQACVLVFSTTDRESFEAISSWREKVVAEVGDIPTALVQNKIDLLDDSCIKNEEAEGLAKRLKLRFYRTSVKEDLNVSEVFKYLAEKHLQKLKQQITEDPEQTHSSSNKIGVFNASVGSHLGQNSSSLNGGDVINLRPNKQRTKRTRNPFSSCSVP
The following text describes a protein:
Function:
Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA.
Subcellular Localization:
Nucleus.
Sequence:
MHEKVLFGGDYILLNLRTRASSGIRGPPSSTPQGKTQNPRHVPRAPAAPQTTRSWAWLTIDYFGLGAERRAHAPAAIGEAWRRGAGYAGKSGGREAAGSSRWAAAPAAAAGGSRMVKLTAELIEQAAQYTNAVRDRELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSILRNPVTNKKHYRLYVIYKVPQVRVLDFQKVKLKERQEAEKMFKGKRGAQLAKDIARRSKTFNPGAGLPTDKKKGGPSPGDVEAIKNAIANASTLAEVERLKGLLQSGQIPGRERRSGPTDDGEEEMEEDTVTNGS
The following text describes a protein:
Function:
Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN).
Sequence:
MKRFVIGIGGVTNGGKTTLAKSLQKHLPNCSVISQDDFFKPESEIDIDENGFLQYDVLEALNMEKMMSAVSCWMENPGSSAGPAALESAQGVPILIIEGFLLFNYKPLDTIWNRSYFLTVPYEECKRRRSTRVYEPPDPPGYFDGHVWPMYLKHRQEMSSITWDIVYLDGTRSEEDLFSQVYEDVKQELEKQNGL
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Subcellular Localization:
Nucleus.
Sequence:
MSEFDMAVIKPEMIKSYIWLQTADGSIQQVEQEVAMFCPMICHEIIQKGMGSSKTYAISLPQRVNPCMLSLILDYCRFHQVTGRSNKERKSFDEKFIRMDTKRLCELTSAADGLQLKPLVDLTSRALARIIEGKTPEEIREIFHLPDDLTEEEKLEPLKNSTDDPRIRLLNRLYARKRKELKEREHLKEVDDNWTCHMFQNVETEEERVDDRSVEDLLSFINGGNGGIHASLEVRKLCFTDSKVLKTSKSKKKNRRRKEQQKNASVDESIESHGKDSNGLNFVCNGTGVDKLQPHPGETSTLPDVEDDTFPHKVEFDDGDIDDEIDPALREKIDREVEDFARRLNSDWPERMQEILSLGQERRPVNENGSLRRYTRPDPEWK
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere. Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MALKAAIDSVKGRIEDLKTSIPQQRTKNKECATVVSQHRLGGHILVHNRILGFHVEGGRGVKFTFKNINVDNPNEEFFFTIRLEDDIYTLLNCKPSVKDTDEVIHELNKTNGLFKFVRTMRKKFQEAVAQGSLSMTTNEHQESAFMSASAPVLSISTITEGNENQDEPIKGNAHLQKQVNRRRVKSPGSASSVCQSPRLKEMKRCGGCSPARYLILMRHAGSCRALIANKLTCKLRHTQVLDV
The following text describes a protein:
Function:
Exact function not known, component of the outer membrane of the vitelline layer of the egg. Seems to be able to synthesize N-acetylchito-oligosaccharides (n=14-15) from hexasaccharides of N-acetylglucosamine in a manner similar to the transferase activity of lysozyme.
Subcellular Localization:
Secreted.
Sequence:
MKVLTPAALILLFFFYTVDARTREYTSVITVPNGGHWGKWGIRQFCHSGYANGFALKVEPSQFGRDDTALNGIRLRCLDGSVIESLVGKWGTWTSFLVCPTGYLVSFSLRSEKSQGGGDDTAANNIQFRCSDEAVLVGDGLSWGRFGPWSKRCKICGLQTKVESPQGLRDDTALNNVRFFCCK
The following text describes a protein:
Function:
Has abundant triacylglycerol lipase activity. Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides. Additionally possesses acylglycerol transacylase and phospholipase A2 activities.
Subcellular Localization:
Mitochondrion.
Sequence:
MKHINLSFAACGFLGIYHLGAASALCRHGKKLVKDVKAFAGASAGSLVASVLLTAPEKIEECNQFTYKFAEEIRRQSFGAVTPGYDFMARLRSGMESILPPSAHELAQNRLHVSITNAKTRENHLVSTFSSREDLIKVLLASSFVPIYAGLKLVEYKGQKWVDGGLTNALPILPVGRTVTISPFSGRLDISPQDKGQLDLYVNIAKQDIMLSLANLVRLNQALFPPSKRKMESLYQCGFDDTVKFLLKENWFE
The following text describes a protein:
Function:
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.
Sequence:
MAFVTASWNPLGEAFYRKVELYEMCWSIRDGLRDSLVAAAPYGGPIALLREPLRRSPSSRPQLEIYSASGAAIASFPWKSGPVVQLGWSISDELLCVQEDGSVLIYDLFGSFKRHFSMGQEVVQSQVLEAKVFHSPYGTGIAIVTGSSRFTLATNIEDLKLRRLPEVPGLQGRPASWVVLTQDRQTKVLLSIGPELYILDNTSCTAVCPPGLSPHAGSIVHMSVSFSYKYLSLFTDSGHLWAGLSNLQDKLLEFDTKTTERPKQMLWCRRPKSQQPSVVLMWDRLLLVVGECNDTIQFPVEDPSVLVGEMDGVRIINSTNQELLQEVPLVCQDIFKIASMAPGALLLEAHREYEKSSQKADEYLREIKEQNVLEEAVRQCVEAAAHEYDPATQKSLMRAASFGKCFLTDFCSDPFVSTCRELRVLNAVRESGVGMPLTHTQFKQMTLQVLIDRLLFRQFYPLAIEICRYLKIPDYQGVSRVLKHWASCKVQQKDLSDEAIARAVCVKVGESPGVSYSHIAAKAYECGRTELAIKLLDFEPRSGEQVPLLLKMKRSHLALSKAVESGDTDLVYMVVTHLKNEMNRGDFFMTLRNQPVALSLYRQFCKLQEQETLKDLYNQDDNHQELANYYVTASYREKKLESSLSLLQNAVDEYNKAKNDFAAKATEEEMRLLRFQRKLDDEKGAGLLGLSLQVTMETLLSLGLHKQAEQLYRDFKVPDKRYWWLKLKSLAEKEEWEELEKFSKSKKSPIGYLAFVEVCMKYNNRNEAKKYICKVTPEQKVKAHLAVGDLESAADAAIEHKSESEIAAVLSRCSASDRLLVDRLNRASGAKK
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MSSTRTRDKENNNKKQQQQPQPGMLQLGNYELGRTLGEGNFAKVKLAKNLHSGHPFAVKILDKAKIIQLNITDQIKREIATLKLLKHPNVVRLHEVLASKTKIYMVLEYVTGGELFDRIASKGKLSESQGRKLFQQLIDGVSYCHGKGVYHRDLKLENVLIDAKGNIKISDFGLSALPQHIRGDGLLHTTCGSPNYVAPEILANKGYDGATSDIWSCGVILYVILTGYLPFDDRNLAVLYQKIFKGDAQIPKWLSSGARNMIRRILDPNPDTRITIAGIEDDEWFKQDYTPAVADDEEEDLYIDDEAFSMDEVASDGTRRPESPTIINAFQLIGMSSCLDLSGFFEEEDVSERKIRFTSNHSAKDLLARIQDIVTEMGFRVQMKNGRLKATQEHRGQKCHGSLSVAAEVFEISPSLYVVELRKSCGDSTVYRQLCKKLSNDLGVRQGQGLVYTQA
The following text describes a protein:
Function:
Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane raft. Postsynaptic cell membrane.
Sequence:
MTQGKLSVANKAPGTEGQQQVHGEKKEAPAVPSAPPSYEEATSGEGMKAGAFPPAPTAVPLHPSWAYVDPSSSSSYDNGFPTGDHELFTTFSWDDQKVRRVFVRKVYTILLIQLLVTLAVVALFTFCDPVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTVFTLSMAYLTGMLSSYYNTTSVLLCLGITALVCLSVTVFSFQTKFDFTSCQGVLFVLPMTLFFSGLILAILLPFQYVPWLHAVYAALGAGVFTLFLALDTQLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNRE
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in proline-rich peptide sequences of plant glycoproteins and other proteins. Hydroxyprolines are important constituent of many plant cell wall glycoproteins such as extensins, hydroxyproline-rich glycoproteins, lectins and arabinogalactan proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MAKLRHSRFQARKWSTLMLVLFMLFMLTIVLLMLLAFGVFSLPINNDESSPIDLSYFRRAATERSEGLGKRGDQWTEVLSWEPRAFVYHNFLSKEECEYLISLAKPHMVKSTVVDSETGKSKDSRVRTSSGTFLRRGRDKIIKTIEKRIADYTFIPADHGEGLQVLHYEAGQKYEPHYDYFVDEFNTKNGGQRMATMLMYLSDVEEGGETVFPAANMNFSSVPWYNELSECGKKGLSVKPRMGDALLFWSMRPDATLDPTSLHGGCPVIRGNKWSSTKWMHVGEYKI
The following text describes a protein:
Function:
As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.
Subcellular Localization:
Lysosome membrane.
Sequence:
MEAAQGRLGPEPELSVGAEHQAATFSGRPSRTPSKPPSVRTLSGEEEAESVGVSSRHPRASPKTWSGSIAHGPELDTWEDKPSSRATPSGARGRRGVPGSEHAPPPSSWYPEPEPSEDQPSALRVCRRGSPGGVEMNVELPQQEGDDDDDEDEEAAAGRAGRSFPSRLQDSRSLDGLSGACGGGGSSSSGETGAGGGRRATISSPLELEGTVSRHGDLTHFVANNLQLKIRLSGAPPPVPPASVRPCLTPAPTPTIPPIDPDVLRDLERLSRELGGRVDRLLRGLGGAVQELTALSVGCIQTYRDAVDSLGEAVDMSIKGMYTLLARCEELERALQPVQGLARQVRDIRRTLEVLEALCK
The following text describes a protein:
Function:
Catalyzes the oxidation of glyceraldehyde-3-phosphate to 3-phosphoglycerate. Uses ferredoxin as electron acceptor. In vitro can also use benzyl viologen, but not NADP or NAD, as electron acceptor. Probably acts as a glycolytic enzyme in place of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and phosphoglycerate kinase (PGK) in an unusual Emden-Meyerhof glycolysis.
Miscellaneous:
MISCELLANEOUS: Two zinc atoms per subunit with no known function have been observed.
Sequence:
MKFSVLKLDVGKREVEAQEIEREDIFGVVDYGIMRHNELRTYEVDPYDPRNIVIFGIGPFAGSVLPGSHRLVFFFRSPLYGGLFPSTMGGAGYQFKNVGVDFVEIHGKAEKPTVIILKNDGEKLSVDFYEIELEKLLDVWKEYKGEEGVYALTQYLLDNLASVFEGMEFRIAVVGPAALNTNMGAIFSQALRNGKRAVGSEDWAARGGPGSVLLRAHNVVAIAFGGKKRKREFPGEDISDVKVAKRVVEGIHKKAQRDVINESTVKYRYNPKLNTGGTFGGNYPAEGDLVPVLNWQMPYIPKEERIKIHELIMKYYWEPFNKESIQPKNWTTCGEPCPVVCKKHRKGHHVEYEPYEANGPLSGSIYLYASDISVHAVDAMGFDAIEFGGTAAWVLELVHKGLLKPAEVGISDVPEFTKDDLITKPVEASEKNAKLVAELAHSIAFGKTEVARIIGMGKRKASKILDEKFKDRLSYGESFKDYGVYTPLGDDGEINPTMYWAIGNFIPLPIQGRYWTFYQFGVFLEPEELAQKIVSSALWEFWYDNVGWCRFHRGWMKKVLKALFMEAYGVSIDMEEHAKKQIRKLIDYLKKAGYEPVFWDSMRVIDLVAKGSEEFGNENWAKKFKEDKIGTAKEYLKRVLDAYSQLIGTEWTL
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MRSAFQDHGLGFHQAITDGGGGGAGPATTAAPWWAAAPHQGCAAARFPIISSSSVSGDPDPRRHELKFHEPPGAAAMAAAAHPELLLHKYHHGRFDLSIGQSMMFSTNAIPDHHSYGTASYYPFYGAHALVCICHTDPFCLGCFSTRLVSHHSIYFYICKKKKKMKHGRVLLPPAIAADEPVYVNAKQFNGILRRRLARAKAACRDRRVSGGNRRKPYMHESRHLHALRRARGTGGRFLNTRSRDDGDPHKPPNEGSAASNKAKAKAAAAAATRLQQQEDRQADALFLSSLVNVAGGDGDGGEATAWPGCSAPSRGCCDLLRS
The following text describes a protein:
Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MASSGSGYDLSSSTFSPDGRIFQIEYASKAVENAGTALGLRCSDGVVLCVEKPLQHKMLVAATTGRRIHTVDEGAGVAITGFVSDGRQIVGRAREEASNYDETYGTKIPPHILANRLSTYVHYFTLHGALRPFGASTLIAAYDASTKKHSLHMVEPSGVSYEYYGCAAGRGRQPARTEMEKLAINPKLQQTGGGSAAEQLTVAEGVKQLAKIIYTLHDPAKDKPFELEMSWLCEGSGWKHVGVPRDVIGSAVEWAKKEIEEADEESEDDEEMEE
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
SLHFGRQRQAFAHVQKGDVKKVKMAVARAGVLGVQWLQRASRNVMPLGARTASHMTKDMFPGPYPRTPEERAAAAKKYNMRVEDYEPYPDDGMGYGDYPKLPDRSQHERDPWYSWDQPGLRLNWGEPMHWHLDMYNRNRVDTSPTPLSWHVMCMQLFGFLAFMIFMCWVGDVYPVYQPVGPKQYPYNNLYLERGGDPSKEPERVVHYEI
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Sequence:
MKTIVLMASNGDEFVVDVEEITNQSEMIRNLISDMGGADGLQVPLLNVTAPVLAKLLELLNVNAKNDAEEVTQIIKELIETDMNTMIDVLGAANYIEATSLFDFSCKVLADKFKAMSVEEIREFLDIECDFTDEELQRIRAESAWAFD
The following text describes a protein:
Function:
Acyl carrier protein.
Sequence:
MATLLTTDDLRRALVECAGETDGTDLSGDFLDLRFEDIGYDSLALMETAARLESRYGVSIPDDVAGRVDTPRELLDLINGALAEAA
The following text describes a protein:
Function:
Involved in regulation of meiotic recombination and repair of DNA damage. Inhibits RAD51-mediated recombination when the meiotic recombination machinery is impaired.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes as foci on meiotic chromosomes.
Sequence:
MQQRSNRRSCSYIPLGVHNNAEKSLCTEVAPARKNKRSITTSPIVNINVVERRLFNLELEKQQLRAKNLSENTGGGSPNGGAYLDAKKGVREQDQYQGGPSKELDRLQPPPSMKKSPPRKKKSLKDLIYETNKTFYQVDSNKVKYKVGLSKKQLLPSKTVDN
The following text describes a protein:
Function:
Binds calcium ions. May play a role in sequestering additional small ligands.
Sequence:
MSVYKVIDIIGTSPTSWEQAAAEAVQRARDSVDDIRVARVIEQDMAVDSAGKITYRIKLEVSFKMRPAQPR
The following text describes a protein:
Function:
Binds the poly(A) tail of mRNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAQTQVPPQAQMQVAISGANVAAGAAAGVPFNSLTSLYVGDLDPTVTDSQIFDLFNQFGQVVSVRVCRDIDTRRSLGYAYVNYNNPPEAARALEILNFTPMNGKPIRIMYSNRDPSTRKSGAANIFIKNLDKAIDNKALYDTFCVFGNILSCKLAMDRSGNSKGYGFVQFEKEDSAQVAIGKLNGMLINGKQVFVGPFLRKQDRDNTVYNVKFNNIFVKNFSETMTEDDLKKKFSEFGKITSAVVMRKGDGKSKCFGFVNFDNSEDAANAVDALNGKKFDDKEWYVGRAQKKSEREQELKVKYEQNIKETVEKNRGLNLFLKNIDDSVSDEKLKELFSDFGTITSCKVMRDSNGVSRGSGFVAFSTAEEAANALNDMNGKMIANKPLYVALAQRKEERSARLQAQFAHMPPVPMQPSGVPRMPMYPASGPGIGQQLFYGQTPPALISHQPGFGYQQQLLPGMRPGGTPFFMPFVQQGQQGPRPGGGRRPGPGGHIPMVQQQMFPRGGRMYRFPSGRNIPEMSIPGASGGMLSSPFDMGGFPGRDGAGISQPIPISALASSLANAPPAQQRMMLGETLYPLVGQIEQDMASKVTGMLLEMDQTEVLHLLESPEALKAKVSEAMEVLRNLAPQQHQNTPVDQLAGLSLNDGEA
The following text describes a protein:
Function:
Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.
Subcellular Localization:
Cell membrane. Cytoplasm. Endomembrane system; Peripheral membrane protein.
Sequence:
MFSKEEPCDVPTDSFWEIDSYKRVVKRSEDGLLLCNDLMKMIQERAEIELKYSNKLKVWSKKWVENIDKSTDYGTNKSVLINSMNEAECLANIHSEMKDSLLEVVNNVKKWRNETYTKTMVGVCKEVKQFEDDFKKAQKPWAKHMNKFLKYKKEYESNVKNEKILKNSLAQSTDEDKKLNERLEKCKKENENIIDKLEAIQKDLDSYKPIYIADMTEVFEKTQDFEEKRLIMFKNTLINMHKCLDISQNDKIPIIYIRWRKSIETSDAKKDLKWWSHIYGPDMSMNWPIIPSKYNVKLNPFMDEDDEAPENISTTQLPPKDETPSKKISYDPELNPFEEPMESADHSSNASSSAMVIAVYDYIAQEADELTLTKGDVFEKLSEKDDQGWCTGSKDGKIGLYPEKYAKPFEST
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Is involved in resistance to the arginine analog canavanine (CAN).
Sequence:
MVKKAKRKARGGAKERQNHVASPNPIAQQDTQNVNAPEDGVTAVNEKKTCPHIDKGIDVEKVSAKLGSSGPVRCEDCREGADNRRAAKGKGKHGKKKGGGESKSASKAIWVCLECGHFSCGGAGFPTTPQSHAVRHARQYHHHLAVQFENPQLRWCFPCDRLIPAEKVEHGTEQKDVFQDIAKMIKGRPSEGPSLDAEDVWFGRGSITSGIKSEASLDIGAYGKSGYIVRGLHNLGNTCFFNSIIQNLLAVNRLRGYFLELDECDGPLAAAFKKLFTETSIGDASRSAINPKSFFGSLCAKAPQFRGYQQHDSHELLHCLLDGLGTEELTARKKLKSSQDHGKSPTYVDAIFGGRLSSTVTCLECGHSSLVYEPFLDLSLPVPTKKTPSKKAQLVSRVKKAKHAPKRSGRVRLKINRDAASFNSQSAQESGSKSFCQVQSSAPIAEGTEVPSDCALVDSLDASSMADDMGLTSHNIYSSLKSKNEKNVDNVTGQPTSEDNFSWLDYLDQDVLPNGNEQNDDCVTGQSTSMDNFTCSEYLDQDIMPKGDDVASQADILSNQGCAAENIVQPNVSLQNDLNAPSDSKLTFGEEACSPDDLMRLDDQGQSKSPDCNIASQFGEEVEVKDWNAREVEHNSASSSRFLSVDSNLDSSARLEEVEAPLQVKDSEILLLPYKEETSTTNDVLKGESEVSPDAAGCEQDLLDFDGFGGLFNEPEPVAGPAEKPLLSGAASMANGFGEASSAIGNSSESDPDEVDSTDAPVSVESCLACFTKPELLSKTEHAWQCENCAKLLREQRMRLKKKLLKPESGDLGNAPEDSNSREIDQRATDGSPGKGLSDAFDGRLVYQNGTNGYSNCMPETSHGADEDPVSHPSEGGVHSSQDEACSLVNCDNQNNGVQLDERSANYESGESENETDSKGVKVERDATKRILIDKAPPILTIHLKRFSQDARGRLSKLSGHVNFRDTIDLTTFVDPRCLQREVYKYRLVGVVEHSGTMRGGHYVAYVRGGPKIAGKEKDAEDYVWYYASDAYVREVPLEEVLRSEAYILFYEEI
The following text describes a protein:
Function:
This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'-cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate.
Subcellular Localization:
Periplasm.
Sequence:
MLNKKLLAVMITAALGVSACGSDDEPIVQADLRVLETTDLHTNIMDFNYYSGKVDPTIGLVRTASLIHAARSESKNSVLVDNGDLLQGSPMGDYMAKVGLQMGDVHPAYKAMNLLDYEVGNIGNHEFNYGLDFLNKSLHGAKFPYINANVYCADDDGCWNGVKKGEHLFTPYIIKEKQIIDSEGNNQTIKIGYIGFVPPQILLWDKQNLTGKVTVEDIVATAKKYVPEMKAKGADLIIAIPHSGIGSTENPGDPMAENATYALTNVKDINAIMFGHSHSIFPDAKYADLPNTDVTKGLLNGVPAVMPGRWGDNLGVVDFKLERKDGKWSVLSASTKARPIYDGATKTPLVERDQEIIDAVAAEHQGTLTFVDQPIGIAAADMYSFLTLVQDDPTVQIVSDAQIANVKAKLPEALKNLPVLSASAPFKAGGRHGTTSDADQYVQVDKGALTFKNAADLYLYPNTMVAVKATGAELKDWLECSANQFKQIDPTQTAPQELINWDGHPTYNFDVLDGLTYKIDVTQPSKFDRDCAVVNASANRIVDLRYTDENGKVFTGEEFAAKEFIVASNNYRAFGGKFAGTGSDHVVLELPDTNREALAAYITAQSKYNEATGKYEGMVNPSADYNWDFKTINTNVTLDIRFQTQDSDKAATFIEANKQREMKKISKDELGFAVYSINLSQDKTK
The following text describes a protein:
Function:
Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency.
Subcellular Localization:
Secreted.
Sequence:
MALWRGSACAGFLALAVGCVFLLEPELPGTALRSLWSSLRLGPAPVPPGSLSPESRLAAAWDALIVQPARRWRRVAVGVNACVDVVISGVKLLQALGLSPGSGRDHAVLHSRSDLEEAFVHFMGKGAAAERFFSDRETFHDIAQAASEFPGAQHYVGGNAALIGQKFAANPDLKVLLCGPIGPKLHELLDDNVFVPPESLQEEDEFHLILEYLAGEEWGPFKAPQANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLEVVTSISDIPTGIPVHLELASMTNRELMSSIVHQQVFPAVASLGLNEQELLFLSQSASGPHASLSSWDGVPDVGMVSDILFWILKEHGRSKSRSSDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETIDTNRVSLRAPQEFMTSRLEPGSRIVLNPNKPVVEWHREGVTFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEAYPD
The following text describes a protein:
Function:
Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGPRAKAVCSLFILLQVLAEPAENSDFYLPGDYLLGGLFTLHANVKGTVHLSFLQVPQCKKYEMKVLGYNLMQAMRFAVEEINNRSDLLPGVLLGYEIVDVCYISNNVQPVLYFLAREDYSLPIQEDYSHYVPRVLAVIGPDNSESTTTVAHFLSLFLLPQITYSAISDDLRDKQHFPALLRTVAGADHQIEAMVQLLLHFNWNWIIVLVSSDDYGRYNSQLLKDRLATRDICIAFQETLPMPQPDQVVTEWERQRLEAIVGKLQQSSARVVVLFSPDLILHNFFREVLRQNFTGAVWIASESWAIDPVLHNLTELRQTGTFLGVTTQSVPIPGFSEFRIRRTPVRLPEPNRTSLEATCNQECDTCQDTTASFNSILTLSGERVVYNVYSAVYAVAHALHSLLGCTQACSKEVVYPWQLLKEIWKVNFTLLGHSVFFDKQGDVLMPMEVIQWQWDLSQNPFQSIASYYPKLRQLKAIHNISWHTANNTIPVSMCSKDCHPGQRKKPVGIHSCCFECIDCLPGTFLNRTADEFDCQPCPSYEWSHRNDTSCFKRRLAFLEWHEPSTIFVVMLTILGFLSTLAIMVIFWRHLHTPVVRSAGGPMCFLMLVPLLLAYAMVPMYIGQPTFFSCLWRQTFFTLCFTICISCITVRSFQIVCIFKMARRLPRAYGYWVRCHGPYVFVASFMVLKVVIVAGNVLATTANPTARPDPDDPNIMVLSCNYRRALLFNTSLDLLLSVAGFSFAYMGKELPTNYNEAKFITLCMTFYFTSSVSLCTFMSVYDGVLVTILDLLITVLNLLGISFGYFGPKCYMVLFYPERNTQVYFSSMIQGYTMGKD