lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Shows partial colocalization with the cytoplasmic pool of F-actin.
Sequence:
MESRPGSFQYVPVQLQGGAPWGFTLKGGLEHCEPLTVSKIEDGGKAALSQKMRTGDELVNINGTPLYGSRQEALILIKGSFRILKLIVRRRNTPVSRPHSWHVAKLLEGCPDVATTMHFPSEAFSLSWHSGCNTSDVSVQWCPLSRHCSTEKSSSIGSMESLEQPGQPTYEGHLLPIDQNMYPSQRDSAYSSFSASSNASDCALSLKPEEPPSTDCVMPGPGPIKVTDDQANVSENSGSSHSTSEDHVTSTSHASSYSDEGHHSGPAKMARGPPEPPVRSDSLPASRAQLLNGEQHRASEPVDSLPQKEKPGLETVLPPRSSNQFCCLSGQDQVTDEDHQNCELSKPSESSQDDCEHLLIEDSSKALDSPKAHDKGSNKEFGLLKEASADLANTLNFGAIPHLRGTMEHRHSAPEQLLASHLQQVHLDSRGSKGMELPIGQDGHQWTVSPLHNNPKGKKSPSLPTGGTQDQTRKERKTTPLDDKLMASVHQSQSDVLLGEVDGHPNRAGRASSDLTSQQPSATCSSVQQTRDFLSAHKIVDHTEASEEGDNEPKECGRLGGRRSGGPRGRSIQNRRRSERFATNLRNEIQRRKAQLQKSKGPLSQLCDTNEAVEETQEPPESPPLSASNASLLPSYKNVPSPGDKVFNKSMILRARSSECLSQASESSKARGGVEGRMSPGQRSGQSSLALNTWWKASDSSTLDTEKANAHHGVCRGHWRWSPEHNAQPQVALSTEAPSNPDDSKELKTSTPQAGEEAVLMPFADRRKFFEESSKSLSTSHLPGLTTHNNKPFIQRQKPIDQNFQSVSYRDLRCHPLDQSYHSADQSYHAADQSYHSLSPLQSETPTYPECFATKGRDNSLCCKPVHHGDCDYHRTCSHPCSAQGTVRHDPCICCSGEICPALLKRNLLPKCHNCRCHHHQCIRCTGCCHGPQHSAHEDSSMAPGNAWKSRKAAIQEFPVDKWKPITGNRKTSHSGREMAHSKAGFSLSTPFRPCIENPALDLSNYRAVSSLDILGDFKRASNKPEESSVYEDENSVASMPRPLRSRAFSESHISLEPQNTQAWGKHQRESFSKGSETQPDTLGARKKVFPPPRPPPPNWEKYRLFRAAQLQQQQQQQQQQQQQQRCEEEEEKEQEEEGEKEEDLPPQYFSSELTGSCAPNTEEQPQSLKMGHQEASRQGSQSLQEQEAFALHPSNFVPPVRGCTVPQPEKAQHPCYYGTHGLWRTTEQEATVTPKQEFQHFSPPKGASGIPTSYSAYYNISVAKAELLNKLKQQPEMAEAGLGEEGVDYELAQKKIQLIESISRKLSVLREAQRGLLDDINANAALGEEVEANLKAVCKSNEFEKYHLFIGDLDKVVNLLLSLSGRLARVENALNSIDSESNQEKLVLIEKKQQLTNQLADAKELKEHVDGREKLVFGMVSRYLPQDQLQDYQHFVKMKSALIIEQRELEEKIKLGEEQLKCLKESLHLGPSNF
The following text describes a protein:
Function:
May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm. Note=Colocalizes with keratin filaments.
Domain:
All members of the FAM83 family of proteins share a conserved N-terminal DUF1669 (domain of unknown function 1669) domain of about 300 amino acids. This domain mediates the interaction with casein kinase 1 (CK1) isoforms. Therefore, it has been proposed to rename DUF1669 the polypeptide anchor of CK1 domain.
Sequence:
MARRSQSSSQGDNPLAPGYLPPHYKEYYRLAVDALAEGGSEAYSRFLATEGAPDFLCPEELEHVSRHLRPPQYVTREPPEGSLLDVDMDGSSGTYWPVNSDQAVPELDLGWPLTFGFQGTEVTTLVQPPPPDSPSIKDEARRMIRSAQQVVAVVMDMFTDVDLLSEVLEAAARRVPVYILLDEMNAQHFLDMADKCRVNLQHVDFLRVRTVAGPTYYCRTGKSFKGHVKEKFLLVDCAVVMSGSYSFMWSFEKIHRSLAHVFQGELVSSFDEEFRILFAQSEPLVPSAAALARMDAYALAPYAGAGPLVGVPGVGAPTPFSFPKRAHLLFPPPREEGLGFPSFLDPDRHFLSAFRREEPPRMPGGALEPHAGLRPLSRRLEAEAGPAGELAGARGFFQARHLEMDAFKRHSFATEGAGAVENFAAARQVSRQTFLSHGDDFRFQTSHFHRDQLYQQQYQWDPQLTPARPQGLFEKLRGGRAGFADPDDFTLGAGPRFPELGPDGHQRLDYVPSSASREVRHGSDPAFAPGPRGLEPSGAPRPNLTQRFPCQAAARPGPDPAPEAEPERRGGPEGRAGLRRWRLASYLSGCHGEDGGDDGLPAPMEAEAYEDDVLAPGGRAPAGDLLPSAFRVPAAFPTKVPVPGPGSGGNGPEREGPEEPGLAKQDSFRSRLNPLVQRSSRLRSSLIFSTSQAEGAAGAAAATEKVQLLHKEQTVSETLGPGGEAVRSAASTKVAELLEKYKGPARDPGGGAGAITVASHSKAVVSQAWREEVAAPGAVGGERRSLESCLLDLRDSFAQQLHQEAERQPGAASLTAAQLLDTLGRSGSDRLPSRFLSAQSHSTSPQGLDSPLPLEGSGAHQVLHNESKGSPTSAYPERKGSPTPGFSTRRGSPTTGFIEQKGSPTSAYPERRGSPVPPVPERRSSPVPPVPERRGSLTLTISGESPKAGPAEEGPSGPMEVLRKGSLRLRQLLSPKGERRMEDEGGFPVPQENGQPESPRRLSLGQGDSTEAATEERGPRARLSSATANALYSSNLRDDTKAILEQISAHGQKHRAVPAPSPGPTHNSPELGRPPAAGVLAPDMSDKDKCSAIFRSDSLGTQGRLSRTLPASAEERDRLLRRMESMRKEKRVYSRFEVFCKKEEASSPGAGEGPAEEGTRDSKVGKFVPKILGTFKSKK
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
MTESKKPEAAKEPVAKEEAKPQEPVADLLEADDLFEEFGTSEWQATKDDESVPMWEADWEDENVADDFTGRLKRELDGARMKD
The following text describes a protein:
Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular Localization:
Nucleus.
Sequence:
MEDSQATNVWEVPAATVAMYRNMFSQFFDSDFSGHEEKYYREAVDNAVNENKKRILINLDHLREFDRLNGHNITQELIKNPKLFQQAINEALNEYRKEVNAKGEQDLTFGITGPIGDHFVSPRQLNTRFLNHIVCLDGIVTKTSLVNPKLVTLVQFCPATNQRLRTQFHDATDLTARPSRFAIPNKDANDNPLEVEYGFSTFIDHQIITIQERPESAPAGQMPRNCDVIADADLADACKPGDRVKVYGVYRILPNKVQGTASGIYHPLLIANSIEVAAQTLQLNLTKSDVENIRFIAGYKENNQLDVEENTHVLDLLSRSIAPSIYGSSRIKEAIVLMLAGGCETNLPDGTHIRGDINMLMVGDPSTAKSQLLRHVLNIAPLAVHTTGRGASGVGLTASVTTDTETGERRLEAGAMVIADRGVVCIDEFDKMDEADRVAIHEALEQQTVTISKAGIHATLNARCSVAAAANPVWGTYNPNRSPMDNVGLPDSLISRFDLLFIVLDQHNPQVDAAIADHVLENHKWKSNGPSTTYSDDGIYLKSDAIPHVSQGEQQNYVTVEFLKKYITHCKDIKPTLTKEANELLVSPWADMRAVMTRKTQPITPRTFETLIRLSTAAAKIRLSSTITEQDANTAISLLKFSVYGEDEEPPKPRTKKLISNDDKKKKSKKTKKTKKDDDNDDSSEPEAVETDEELENSSEEQSAASESDAEEKEGEQVKEDELPKLVESYVGDELDEKRKAFQEVYKYYINQTDKVFVTLDQFIETVELQKGVVITRDELKILLSENKNVTFDDENIAF
The following text describes a protein:
Function:
Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSSGSVQIHHVWATNFDAEFHLLTQMLSYFSNVTIDTEFPGAIYPSRPPSFPSLQYSEKYYQSLKANVDCMNLIQLGITLTDNYGRLPKFDDHYVVWEFNFRDFDVSTDLQAPEAIQLLRSHGIDLEKTREHGIDSALFAQRMCESGLVHYDLASGTRLLHRSYYDIASGIRYLVRPRWICFQGGYDFAYLIKILSHGRPLPETINDFLDVMNHVFGAVFDVKHMMKCHGLYGGLERVAKTLGVVRSVGQTHCSGSDSLLTWQIFEKLCKCFGKVDWSEAMGVIAGLECHALNRRLQL
The following text describes a protein:
Function:
Catalyzes the oxidation of 1-deoxy-11-beta-hydroxypentalenic acid to 1-deoxy-11-oxopentalenic acid in the biosynthesis of neopentalenolactone antibiotic.
Miscellaneous:
MISCELLANEOUS: S.avermitilis does not produce pentalenolactone itself in vivo but instead a group of new metabolites that are neopentalenolactone derivatives.
Sequence:
MHLQPSTAVVTGAASGIGFALSARLAQAGARVVMTDIAGDGLAGAVEELAAHGADVTAVVADLTDPAAVQELADTAFGRLGDIDVVCNNAGVVGPVGMPLWSVPLDEMHAVFDVNYWAHVHVARAFVPRLLDSGRPSHLVQTASMSAFVVGAGTASYAASKHADLAAARSLRADLDGTPVRVSVLCPGRVDTPMTRGLVAPRNATGNTTISADEAADAVWNALGSDRFYIFTNADAQTRLGDQFNDVWRHLAREKYWTESSSPSVNSSRP
The following text describes a protein:
Function:
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MGLEAFLPVALVIGYLLGSIPFGLVLTRLAGTQDIRSIGSGSIGATNVLRTGRKSLAAGTLLLDALKGTVAVVIAGYIAGPNAAMAAGLGAFLGHLFPVWLKFKGGKGVAVYIGILLGLFWPAAVVFCLLWLATAFTTRYSSLSALVASFITPMFLWWFGHLALSALFAVLTLLLFYAHRENIKRLQSGKESRIGEKA
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Sequence:
MSALLSVTDAHVAYGKVEAVRSVSLEVGANQIVTIVGANGAGKTTLLSAIMGILPLKGRVAFAGQDLARLDIEDRVAMGLGLVPEHRELFVTMNVEDNLELGAFRIERSKSKASMERVYTLFPRLKERRKQLAGTLSGGEQQMLAMGRALMGEPKLLMLDEPSLGLAPIIVADIFRIVTELRTAGVSVLLVEQNAQAALKIADQAYVMELGEFVLSGKASDIAANERVAASYLGFQHEGASVL
The following text describes a protein:
Function:
Involved in the maturation of Asn-linked oligosaccharides. Progressively trims alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
Subcellular Localization:
Cytoplasmic vesicle lumen.
Sequence:
MPRRWSSLISITAIFLVLFFLLHRNTDTPRAANRATNGPANGFARQQSICPSTPPQPPYNRTSTGGFNWGEIPVRYPVSDFIPLSTNSPATLPRIQRSSFPLQSSITKSRQAAVKGAFQRAWTSYTTHAWKADEVRPITAGSRNNFGGWGATLVDNLDTLLIMGLDEEFAAAVDALADIEFSPHSSPSSSQSTINIFETTIRYLGGLLAAYDLTGCRETRLLDKAIQLGEMIYTSFDTENRMPVPRWNLHKAGNGEPQRAAVQGVLAELASSSLEFTRLSQLTGDMRYFDAASRITDLLDSQAGHTRIPGLWPVSVNLQKGDLTRGSTFSFGGMADSAYEYLGKTYRLLGGVGKGPQYERLARNALDAGIRHLLFRPMTPDHADILLPGVAHATSSSVGLEPRTEHLACFVGGMYALAGKLFSNQTYLDTGRKLTDGCIWYYDNSPLGIMPEMFTVPACPSVAECPWDETRGGIYTYVRDGHYFLRPEAMESIFYMWRITGDEKYREAAWRMFTAIEAVTKTEFGNAAVRDVMVEEGNVKREDSMESFWMAETLKYLYLIFGETDLVSLDDWVFNTEAHPLRGAGS
The following text describes a protein:
Function:
Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux. Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner. May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein.
Sequence:
MWAWALLPIAMAMLGTVGFWAVFGMAVSNGSVNLTREFPYISTCGTYNPQSCIFAQVLNLGSLMVVWIVLIRYQQIKDYGQSSRVNVAGLVLGFGCALGCSFVGNFQQSVLMGAHLFGAFLAFFVGLAYFWVQAYLTYTVAPRHGGRWIGPARVGLCSACTVLIVSMSVLHKQQYRSAAAGCEWAAAMTFFLLFALFAVEFRHVDCHRYHVQKRAVPAGGAMPAEVASQAQAP
The following text describes a protein:
Function:
Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
Subcellular Localization:
Secreted.
Sequence:
MTPQLLLALVLWASCPPCSGRKGPPAALTLPRVQCRASRYPIAVDCSWTLPPAPNSTSPVSFIATYRLGMAARGHSWPCLQQTPTSTSCTITDVQLFSMAPYVLNVTAVHPWGSSSSFVPFITEHIIKPDPPEGVRLSPLAERQLQVQWEPPGSWPFPEIFSLKYWIRYKRQGVARFHRVGPIEATSFILRSVRPRARYYVQVAAQDLTDYGELSDWSLPATATMSLGK
The following text describes a protein:
Function:
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MASKVKVGIIGGTGLEDPQILENARLIENVDTPYGKISDKMLEGSIHGVECVILSRHGRAHDINPSNVNYRANLWALADQGVTVIIASTACGSLQENVKPGDLLFPDSVYDRTFGRKITFFDGEDGHQPGVCHIPMHPLYHEPLRQILISTAKSLQSSMPDLALHEEGFGVCIEGPRFSTRAESRVFRSWGAAIVNMTMIPEGPLAKELGIPYAPVALITDYDCWKDDAEHVSVELVSATLRANADKAKRLFIEAIKEIAKKDWTEEVKELKASIRASVMLPSEVKIKHLDAGDH
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MGASSSSQERQVPEPEDLGQFRKNAGIRIGDTYLIPEIPAKRKVTDFKFTVVFGICLIILVPFLIYTFVQSDLDRFIHGYDKCGNICGEKNSRVGDVSCSGQDKTYQPFLRLIKNEHAYSDDDQLFIRDECVRECGSGYVELFNRCFPSKSNDSPRVNRDMETTFADIGRDINKSAGYIVLMCLLGLVFTVGMLFLFRYFVAVVVWVILIGSLLGIIALAIIFWVLNSREATGPNAASAQFFAIFFTILAVILTIVLICMFKRIKLIIRLFKEAIKVIFGIPIIVFEPLLTFVASSIVLIIFVYFLIVMSTAGVLQKTFFDVYEYTPNVAILFTMFFHIVICLWMWQFIIGCQHMVISGAVSSYYFARDKSSLVSPVYTSFYNLIRYHLGSVIFGSLIITVIAIVRALIRGLVNNKSARILVDCCLGAIEDFLKFLSKNAYILTAMHGQPFFKSGKRAVRLLAANALSTIALNSVGDFVLAMSKILIVVATILVGCLMADPTIEHFWAAILISAIVTAIVADCFFAVFETAIDTIFLCFCEDSCMNDGTERPYYMSVNLMQYVEEAKKATNNKN
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MATPSLARTIKNFLALGPREYIRQLWYICDPKPGAFRGSDEHGNKYYQDPSESMFRNRWVDYKVHDFNASQVSPEWHSWLQHIRKDPPHLDPIVVQSRQSWQMPHVENITGTRGAFKTYSTTLPKVQSWEPRVSERTSS
The following text describes a protein:
Function:
May participate in the coupling of lysosomes to microtubule plus-end-directed kinesin motor.
Subcellular Localization:
Lysosome membrane.
Sequence:
MSRGNELVFKAKKTSEKISENIHIFANDPSLAFFRVQEHVRKVTPAIFEKRDEVFQLQNNLQGHCYDMEYGIQALRTIEKSESIFENIQEMIKASIFLKQQLKYEESRKKVKKDSTKSSVYKRFSAHLALDLPDLPDFGGVMRETSQRMENMIGPGTATGRTEAQAATSSNPGELQRSYTTLH
The following text describes a protein:
Function:
May play a role in the process of sperm capacitation.
Subcellular Localization:
Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cell projection, cilium, flagellum. Note=Colocalizes with PRKACA and TCP11 on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm.
Sequence:
MTLSTEESIEMFGDINLTLGMLNKEDIVNKEDIYSHLTSVIQNTDILDDAIVQRLIYYASKDMRDNNMLREIRMLAGEVLVSLAAHDFNSVMYEVQSNFRILELPDEFVVLALAELATSYVSQSIPFMMMTLLTMQTMLRLAEDERMKGTFCIALEKFSKAIYKYVNHWRDFPYPRLDANRLSDKIFMLFWYIMEKWAPLASPMQTLSIVKAHGPTVSLLLHREDFRGYALGQVPWLLNQYKDKEIDFHVTQSLKQILTAAVLYDIGLPRSLRRSIFINLLQQICRAPEPPVKENEMKASSCFLILAHSNPGELMEFFDEQVRSNNEAIRVGILTLLRLAVNADEPRLRDHIISIERTVKIVMGDLSTKVRNSVLLLIQTMCEKSYIEAREGWPLIDYVFSQFATLNRNLEKPVKTNFHENEKEEESVRETSLEVLKTLDPLVIGMPQVLWPRILTFVVPAEYTEALEPLFSIIRILIMAEEKKQHSAKESTALVVSTGAVKLPSPQQLLARLLVISMPASLGELRGAGAIGLLKILPEIIHPKLVDLWKTRLPELLQPLEGKNISTVLWETMLLQLLKESLWKISDVAWTIQLTQDFKQQMGSYSNNSTEKKFLWKALGTTLACCQDSDFVNSQIKEFLTAPNQLGDQRQGITSILGYCAENHLDIVLKVLKTFQNQEKFFMNRCKSLFSGKKSLTKTDVMVIYGAVALHAPKKQLLSRLNQDIISQVLSLHGQCSQVLGMSVMNKDMDLQMSFTRSITEIGIAVQDAEDQGFQFSYKEMLIGYMLDFIRDEPLDSLASPIRWKALIAIRYLSKLKPQLSLQDHLNILEENIRRLLPLPPLENLKSEGQTDKDKEHIQFLYERSMDALGKLLKTMMWDNVNAEDCQEMFNLLQMWLVSQKEWERERAFQITAKVLTNDIEAPENFKIGSLLGLLAPHSCDTLPTIRQAAASSTIGLFYIKGIHLEVERLQGLQEGLESDDVQVQIKISSKIAKIVSKFIPNEEILMFLEEMLDGLESLNPTCTKACGIWMITVLKQQGAALEDQLLEILGTIYHHMPVLRQKEESFQFILEAISQIASFHMDTVVVNLLQKPLPFDRDTKTLWKALAEKPASSGKLLQALIDKLETELEDDIARVEAISVACAMYEVISMGTSVTGLYPELFTLLLKLVSCTLGQKMLTCPWSHRRHVMQQGEQQQIPDPCRLSTATLKCLQAQAMREGLAKESDEGDNLWTLLSSPSTHHIGVCSLARSMAVWQHGVILDIMEQLLSSLTSSSENYRITGAAFFSELMKEPILWKHGNLRNVLILMDQSAWDSNATLRQMAIRGLGNTASGAPHKVKKHKQLMLESIIRGLYHLARTEVVCESLKALKKILELLTDRDVSFYFKEIVLQTRTFFEDEQDDVRLTAIFLFEDLAPLTGRRWKIFFAEEIKKSLISFLLHLWDPNPKIGVACRDVLMVCIPFLGLQELYGVLDRLLDQDLPRARDFYRQFCVKLAKKNQEILWILHTHSFTFFTSTWEVIRSAAVKLTDAVVLNLTSQYVELLDREQLTTRLQALRQDPCISVQRAAEAALQTLLRRCKETSIPL
The following text describes a protein:
Function:
Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication. Connects the central plaque of the SPB with the half-bridge. Required for proper localization of CDC5 at the SPB and for proper M-phase progression.
Miscellaneous:
MISCELLANEOUS: Present with 922 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Associates with the periphary of the central plaque.
Domain:
The C-ter coiled-coil domain is sufficient for localization and homodimerization.
Sequence:
MNQEDNTGGGGIFGLFKWTKDALFGTDISPSMKYKDQEERRDRSRYAQDDTNFSMKFGNDSNRRSTNLSRSNSWSGLDSTLHRKYELLPEYNENGFNSIVNGDHHSKERIRSLRSPAPIVPREPLRNEPTDTFGHRLHTKRRTINELSNSQIPFIPPQEDDPLLSKLFNKDGVNEVRRSPYKLSVKDIPGKFPSPLTKRDEIDNYYVRDEDACHKNREYKKAYFDLFAQMDLNSRDLEDLCEDVREQREQFHRNEQTYKQAYEEMRAELVNELKKSKTLFENYYSLGQKYKSLKKVLDQTISHEAELATSRERLYQEEDLKNFEIQTLKQRLSDLELKYTNLQIEKDMQRDNYESEIHDLLLQLSLRNNERKDTSAGSNIFSTGQ
The following text describes a protein:
Function:
Probable zinc protease.
Sequence:
MKLLNIFTIATVASAMSLRRQEPISHVEPADTIFHIDPDLLQPHSSFSLSVKVPIPEGGAHYNRLQQRWYVHADPNARRDAESFFKKRSIGHIGEDIAAHGGLEGWTRDPTDVFKYLMRNDSSPIEAPSGFEEYKLVLTPSDVDMLDKALSSTPSLLYKGTAYRKLNVYDQQTGDVAASYRKVGWARIMVKKVPDEEPQVEGAWMVDDPTGLGVPGTVYHISDQESFRAMANADPDQSKAEMKLMKRALVDKPTSMLVWRESDAYTKDLESPTDYSFVTKEMTILSKRQSDIGGGGSSSGLALSSTIGDTSGCPNHKQIALIGAAADCNYMKDFNSTESVRANILANMNTISQLYEQSFNISLGLKALVLANSTDCPTTAVDSAPWNYECTATQPNAISDRLSAFSQWRGDRSSDGIAAWTLFTDCAQGSTVGLSWLGVLCGARASQQGNTWVAGTNVVAKTSLEWKVWAHELGHIFGAVHDCTSQTCSDGTVDKNDCCPMSTSACNANGQWIMNPASGQQETTFSECTKGNICAGIGRNSLNTSCLIDNTGGIKLLTENECGNGIVEEGEDCDCGGEEGCRGNTCCDPKTCKFRTGAVCDDANQACCNQCQFAPSTQECRSSKGPCDPAEFCTGNSSSCPPDLTTENGKSCEDPSRPGFGGLQCIAGLCTSRDLQCFTLMQNRTTLVGNTPANVTQACDQGRCSISCRDPNLPNVCFGSQYNFLDGTPCGRGGKCLRGQCSGNTNDYFRSWFDDAGGWISRNTGAFVGIIVGVVGGIIVLILIGCFRRWRHRKRAMPVYPVKNNYARRAPPPPPPMGGNRGPIGGAGGANMYPPPPPAQYPFKYESRQSQQYPSQDVYPPAAPPPSYSRQW
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein.
Sequence:
MFGFGMPEMIIILVIALVVVGPSKLPQLGQALGSSIKSFKKGMNEDEVKVINKTNEA
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MQMETYEKGREEYQRRYGKLKDYISSLKTKDTSEITKFDSSDFDLTKLQARLVDQAEKEKFEENIIGSTDIVEQVNHDFNVLVYGIGSKIELLEKAMKELMESNPQSYFFVLKGFKPLVNMKMFLQKMSEVLKIDSHVRNSEQIIKCIENTPQSIIIIAHSIDGRHLLNEQAQKLLGQLSNCPNVRMACSFDNYRYPMICKIQRAFFSCVHTNRPYVQEILQIFEDQVGKQKQEEGLWYVLSSMTQKQKNIVYYFAGKVLESRDGLNFQDLYDVLSDEMIVSSKIQLKDNLKELMDHKIIIEKGGKYTMQYSNTILQELSQKFDEVIKQ
The following text describes a protein:
Function:
May be involved in cytochrome c oxidase biogenesis.
Subcellular Localization:
Mitochondrion.
Sequence:
MLPDLSPHLHTKECNMLIEFLQRCHSEKPIGKMIGKCSYWDEAVWQCTKKERIWRRDNNPAYKRRIVELRSLPEKYWTPALHKLKEDGVLIGGADQSQGCKI
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Domain:
The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
Sequence:
MAPRTKKKAAPKKKAPIKKKEVTEDNSSYVWIYGEPTIKEKCYEFHKDLQEHIEKVFLDKKPNCKVYIYGKIWVLDFAKMTEHNAQKQVTWPIKRVRTSQLKRLKCRGIAGTDYEVKPAHGFWQDDDHCNACYYKSTIPTRLSCGHVFCFQCLRCNWIHGRDCPTCRMQYSREMFVRPTRSDIDFHMECPPGYQEDCAGVLGPAPKTSARRNPPRGHGGEPEKYYWIYEGRHRPGWFRFDPRSEYMIEESFKRKKKTLLIYICTFRMTINFQKMTQTSQSHRVRESESFLTNSRAIKRIPAADYKKYVLRGIAGIRSLAYPID
The following text describes a protein:
Function:
GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes. Also converts Cdc42 to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death. Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins.
Subcellular Localization:
Cell membrane. Cytoplasm, perinuclear region. Endosome membrane.
Sequence:
MGLHPLEFSECYLDSPSFREKIKAHEAELDKTNRFIKELYKDGKNLINATKQLGMAQRKFAQCLGEFQFEYIGDAKTDDERCIDESVQEFSSFLKNLEDQRELMMRNITETLMKPLEKFRKDQLGAVRAERKKYEKETEKYYSSLEKLLNMSAKKKEPQLQEADIQVETMRQHFQEESLDYVCKLQEIQERKKFECVEPILAFFQTVFTFYHQGYELAKDFEYYKRSLQISIQNTRSRFEGARSEVYELMKRTKQAPQEYRQTSSISCEGYLYVQEKRPPPFGSSWVKRYCTFVKEQKILHMVTFDHRSGGKIGETESVTLKSCLRKTTDTLDRRFCLELDITDRPGTVFTVQALSEDDFKFWMQAMGGKEPTGGYLGRTLSKERGIDAQLDDVGLNFVKNSISAIEVRGINDQGLYRIGGVSSKVQKLLSLMIDEKSKEVDLSASEDWDIKTITSALKLYLRSLPEPLMTYGLYKEFISLAKGDSPESRIQAVHCLIHKLPERNRQVLGLLMKHLANVAAHSKQNLMTVANLGVVFGPTLMRPQEETVAAIMDLKFQNIVVEILMEHHEKIFTDAPELSSPASNEPVASAPTRQSKKVSRQSRPLAVYNPQVLDIQNAVGNNCSLATDETSMGSNESVSSQSSTASASEVSTEKTEHATLCSSLSSGSSSRSTTAAACSSAPEAPSESPPLASTAASEKDKEKPEESVTGRKAKAVYPCEAEHDSELSFQAGAIFNAVIQSREPGWLEGELEGKRGLIPENYVEML
The following text describes a protein:
Function:
Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.
Sequence:
MASPSLHWEKLGDKFWRSKEVCQLNWFGGNNSSGDDTLEMSCSATCLSLFAIEVDNSVHVFDRTGHFITKTAIDQKFGKLVKLAFTEDEDLVLVYTNGVEILKDWNVSDKISVPLVVDVDDTIWDYKSGVLILRNSKDIYQLIDNKLVLLHKNTENYEILVKDGWDCKNGDVVILDLDSVWRFDLRSHHFKKIIAGCHYHRLYLSYNGQLCLYNGKGDRLDFYSLKGDDLNRNITLQKAPRDIKWDFEGNLSVLYEDELFLYNSQSQYVSFWYPYGIVLLEIFLDGILVVTTNQLSFVTQVKESTSSIFKIGSVTAGALLLDAFKELETNLPKAIENLRSIDLSTAVVDCLTASLEESDVKVQKQLLGAASFGKESLPYKSFDSSFFVSICNKLKILNFLNSIDFFITNDEYDYYKIEGILDMLLKMGKYYESIKLLELANRPDLKPKVFVQWCIVKIRVSSDLEDIKILDIINKQLSVLNTKNNVPMATIAGYSYSEGRFKLARELCKMEKLTPTKVAMLMKLEDYNIAVQECLHEGSCALTISLLLELKDKLPASQFTKLLILEMRDTQLFPYYEQDNYEFLYDYFRQIDEYKDLAHVLRRSVNKNLSLQSIQPQILELYNTIPHKTEHLKQDISLIQREVKRNQYMTEINNKLGTNFEREPLNDVLAKLIELKQDRVAKDLVKKFDIPERNFHITTLKVLVKQKRFEELSSFMTGIRPAISYQYIFDYIKKRGHKLEASEYISHLHVSYSDKMALYLECKNYRAAVELAGREKDVMGLKDVYAKIPANEPQVKALANQILATL
The following text describes a protein:
Function:
Plays a role in the stress response to heavy metals such as copper, probably in a kgb-1-dependent manner.
Sequence:
MKLFALLVSITLCYSFPAPLQTNVSEPFGLLQKVSEQVIDPDYNIPEVKDAPAIPYDERNSPTHAYSVDISFHTTPSDMDCLRDQGYKSVFVRALNPIGNTYFDRNALNTINNAFEAGLGSEVYITPNINSTRSGADQISLVYQNLLANGINVRSIWIQVTSPTNWVAPMAVRIEFIQDMIRSAKNLGLSVGIYTSFYDWLEITGGWNTFSSDVFLWYWHVLSMGTDGETTPTLEDFRPFGPWRQATVKQFGQVEKLCGMIVNRNVYSTGNQHLSQIVHFSTHQENSSSEKKLIRVGGIGF
The following text describes a protein:
Function:
Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
Subcellular Localization:
Nucleus. Note=Found in the nuclear body.
Sequence:
MFTMTRAMEEALFQHFMHQKLGIAYAIHKPFPFFEGLLDNSIITKRMYMESLEACRNLIPVSRVVHNILTQLERTFNLSLLVTLFSQINLREYPNLVTIYRSFKRVGASYEWQSRDTPILLEAPTGLAEGSSLHTPLALPPPQPPQPSCSPCAPRVSEPGTSSQQSDEILSESPSPSDPVLPLPALIQEGRSTSVTNDKLTSKMNAEEDSEEMPSLLTSTVQVASDNLIPQIRDKEDPQEMPHSPLGSMPEIRDNSPEPNDPEEPQEVSSTPSDKKGKKRKRCIWSTPKRRHKKKSLPGGTASSRHGIQKKLKRVDQVPQKKDDSTCNSTVETRAQKARTECARKSRSEEIIDGTSEMNEGKRSQKTPSTPRRVTQGAASPGHGIQEKLQVVDKVTQRKDDSTWNSEVMMRVQKARTKCARKSRLKEKKKEKDICSSSKRRFQKNIHRRGKPKSDTVDFHCSKLPVTCGEAKGILYKKKMKHGSSVKCIRNEDGTWLTPNEFEVEGKGRNAKNWKRNIRCEGMTLGELLKRKNSDECEVCCQGGQLLCCGTCPRVFHEDCHIPPVEAKRMLWSCTFCRMKRSSGSQQCHHVSKTLERQMQPQDQLIRDYGEPFQEAMWLDLVKERLITEMYTVAWFVRDMRLMFRNHKTFYKASDFGQVGLDLEAEFEKDLKDVLGFHEANDGGFWTLP
The following text describes a protein:
Function:
General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.
Sequence:
MSNSNINNKKFTGPNLNVTLICPDCKQFPPDLIERFSEGDIICGQCGLVLSDRIVDTRSEWRTFQNDDKNTDDPSRVGDASNSLYDTEDLTTMISYAPNSNSGSSKNSLNKIQQKSLVDKKNYALQTAYQKISELCNGYQLPKSASDAAKHLYKAVREDRLLKGKTQDSIMAATILLGCRRADVPRTLEEIRALTNVPTKQIAKVTGLIKKIIRSHLNNDDASTSIVDETSSLTTHSAEDLIRRFCSHLGLSLAITSASEYVARKCHDLGVLAGRSPTTIAATSIFLAAKSLGDTKLTQQQIRDKTGVSIGTIKNSYKILQENAKDLIDPAWEANSKVKRENTPKS