lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Central component of the spindle assembly checkpoint. Thought to recruit MAD2 to unattached kinetochores. During checkpoint activity, MAD2 is relayed from the MAD1-MAD2 complex to the mitotic checkpoint complex (MCC). The formation of a MAD1-BUB1-BUB3 complex seems to be required for the spindle checkpoint mechanism.
Miscellaneous:
MISCELLANEOUS: Present with 656 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MDVRAALQCFFSALSGRFTGKKLGLEIYSIQYKMSNSGGSSPFLESPGGSPDVGSTNGQSNRQIQALQFKLNTLQNEYEIEKLQLQKQTNILEKKYKATIDELEKALNDTKYLYESNDKLEQELKSLKERSANSMNDKDKCIEELRTTLQNKDLEMETLRQQYDSKLSKVTNQCDHFKLEAESSHSLLMKYEKEIKRQSVDIKDLQHQVMEKDDELSSVKASKMINSHPNYSTEEFNELTEMNKMIQDQVQYTKELELANMQQANELKKLKQSQDTSTFWKLENEKLQNKLSQLHVLESQYENLQLENIDLKSKLTKWEIYNDSDDDDDNNVNNNDNNNNNKNDNNNDNNNDTSNNNNINNNNRTKNNIRNNPEEIIRDWKLTKKECLILTDMNDKLRLDNNNLKLLNDEMALERNQILDLNKNYENNIVNLKRLNHELEQQKSLSFEECRLLREQLDGLYSAQNNALLEVENSETHASNKNVNEDMNNLIDTYKNKTEDLTNELKKLNDQLLSNSNDVETQRKKRKLTSDQIGLNYSQRLNELQLENVSVSRELSKAQTTIQLLQEKLEKLTKLKEKKIRILQLRDGPFIKDQFIKKNKLLLLEKENADLLNELKKNNPAVETVPISVYDSLNFELKQFEQEVFKSNKRFSRLKQVFNNKSLEFIDVVNSLLGFKLEFQQDSRVKIFSCFKPEKYLIADLNENTLKSNLDADIEGWDDLMNLWVEDRGQLPCFLATITLRLWEQRQAK
The following text describes a protein:
Function:
Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. Promotes floor plate development and prechordal plate development. Required for lens development as early as the stage of lens field formation, partly through regulation of gene expression of the cell cycle inhibitor cdknx/p27(xic1). Required for formation of the neural crest downstream of multiple signaling pathways, and acts at the neural plate border via both DNA-binding dependent and independent mechanisms. Also acts via repressor-dependent and repressor-independent mechanisms in early gastrulae to establish the prospective anterior prechordal mesoderm identity in the Spemann organizer; induces specific genes independently from direct transcriptional regulation, and represses the genes specific for neighboring tissues through direct transcriptional repression. Modulates lateral inhibition during notch signaling and regulates the cell context dependent effects of notch (which can have inhibitory, permissive or enhancing roles in muscle or neural differentiation). Inhibits myogenesis (By similarity).
Subcellular Localization:
Nucleus.
Domain:
Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG); The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins. The WPRW motif is also required for the inductive function, independent of transcription regulation activity (By similarity).
Sequence:
MPADSMEKPTASPIAGAPASSAQTPDKPKSASEHRKSSKPIMEKRRRARINESLGQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRVQMTAALTADPSVLGKYRAGFNECMNEVTRFLSTCEGVNTEVRTRLLGHLSSCLGQIVAMNYQQPPSSQQPLHVQLPSSTPAPVPMPCKVNPAEAISPKVFQGGFQLVPATDGQFAFLIPNPAYTTSPGPVIPLYANTNVTSPGGPQSQSPVQGLTTFGHKMPHMAQAVSPLGGSTGADSAESVWRPW
The following text describes a protein:
Function:
Serine protease that cleaves preferentially after Arg residues. Can also cleave after citrulline (deimidated arginine) and methylarginine residues.
Subcellular Localization:
Cytoplasmic granule lumen. Secreted. Note=Stored in cytoplasmic granules and secreted as active enzyme in response to stimulation of neutrophils.
Sequence:
MVPGTGGGRDCLTLVVATALTQLLWLPGCCGSHIVGGHEVKPHARPYMASVNFEGHHHCGGFLFHAHWVLSAAHCFSDRDPSTGLVVLGAHALLTPEPTQQVFGIAAVVSHPDFEPTTQANDICLLRLNGSAVLGPAVRLLRLPRRGAKPPVAGTRCRVSGWGSVSDFEEPPPGLMEVEVRILDLSVCNSSWQGQLSPAMLCTHSGDRRRRGFCSADSGGPLVCGNRAHGLVSFSGLWCGDPKTPDVYTQVSAFVSWIWDVVRASPTPGSMGCSLRAV
The following text describes a protein:
Function:
Under salt stress, appears to prevent the accumulation of reactive oxygen species (ROS) in roots and required for the maintenance of cell wall integrity (cellulose, pectin and lignin composition) by interacting with importin alpha (e.g. IMPA1 and IMPA2) and binding to the promoter of several ROS- and cell wall-related genes to regulate their expression. Necessary for cells organization in meristems and root elongation zones as well as for root elongation in high salinity, but not upon osmotic stress.
Subcellular Localization:
Nucleus.
Sequence:
MDYDDSDFQNQNLHLAGEANNKFPPVLQPYALPKFDFDDTLNTHLRFDSLGESEAFLGIEGNEDNNWIEDFSRGSSGIVFSSGATESCAISRHNNVWSEATSSESVAMLLNSVGQDEVIVREDTIKKSDTSHELGCTMETVEPGQTSHERSLSKEETVNLQPNPSVDDTPGESSVVKTDDGQEQVLVKDDSPTAVEEASVEEKNSILTSNTATVEAIDTTDLGKIGTETTDNLLDQTEEKANVESRMEDDCSDGNVQTIITCSGELNNQSTLLPETSNDENVISDHIQSSYNRNDLTADARSILVEGHSDSHIDSASEVEKVEAENIGKTAKPDLKEIELSDVTVLERGDQAPSTLEVGGQDVSGTECQDLLVSTVHTSVAVEASLELAGELTTITNSVSIEKPELLSHQHMEVITSEHESTFQIETETYPQIHVFETSESVYISTMDSMVEAREGGVSKKSDNEGSARTSNLEQSMELPVNANDRDQDVKNSQILSESVVSGSVGYVSGGSTSELAESESQSDSIPTDKSETMIDSSLNLEELQPLSQDGAPAVSLTSSIDLHMVKTSSDDSDQGSYSETKKVYGEPENGQTVPPVDASCSGSQMDQEARKRAEGTKQSTYSVEGCPRSEGSKDAVDADGVGQVLQQQSEELIFEENVVTEAVKAPETLSVLDKDNKNEMPITSSLPILGSEAGKDGQEEDNTAASGGIMAAGTPVTHPKGDAIVLGDSRASTCSESSVKSYVTAIEDAATNLKTPLDSFPTVKTSELQFNNTETNSVKKPEDQNISGFMSAGSPVLNRNETSSSEMNLTPDQLKAGKISKAVIFSQATLVSPIVVGSPSTSSLDKTAAKSSKAKSERKPRRTSKSVGKETSRKGTSVKGATPIEQFQSGGKTNAVNQSLASHIQITQSTEKQRSLQSPALKAFGSLSTPTASLPDLNSSALSSILRRPFTDLQQVQLRAQIFVYGALIQGTAPDEAYMISAFGGADGGKGSWEKSWRTCVVRAQKSLVATPETPLQSRPGKTETPSAGHTNSKESSGTNPMIPLSSPLWSLSTSVDTLQSSSVQRGSAATHQPLLSASHAHQTPPTQNIVGHNTPWMSPLPFRNAWLASQQTSGFDVGSRFPVYPITDPVKLTPMKESSMTLSGAKHVQSGTSSNVSKVTPTLEPTSTVVAPAQHSTRVKSRKRKKMPVSVESGPNILNSLKQTELAASPLVPFTPTPANLGYNAGTLPSVVSMTAVPMDLVSTFPGKKIKSSFPSPIFGGNLVREVKQRSVLSEDTIEKLKEAKMHAEDASALATAAVSHSEYVWKQIEQQSHAGLQPETQDRLASAAVAIAAAAAVAKAAAAAANVAANAALQAKLMAEEASLPNASDQGLPKSYDSILPGQGTPASILKGEGAVVNSSSVLIAAREASKKRVEAATAATKRAENMDSIVKAAELASEAVSQAGILVSMGHPPLLNKLVEAGPSNYWRQAQESQEVQPCKTVVLEKETVSTSEGTFAGPKIVQTEFGGSVNTADGVSGPVPATGKLKGQEGDKYADLAKNNDVVFEPEVGSKFSIDAQQTIKATKNEDIKEGSNVEVFKEEPGLRTAWYSANVLSLEDDKAYVLFSDLSVEQGTDKLKEWVALKGEGDQAPKIRPARSVTALPYEGTRKRRRAALGDHIWKIGDRVDSWVHDSWLEGVITEKNKKDENTVTVHFPAEEETLTIKAWNLRPSLVWKDGKWIECSSSGETISSSHEGDTPKEKRPRLGTPALVAEVKDTSMKIVDDPDLGKPPQTGVLNLGVSENTFNIGKSTREENKPDPLRMKRTGLQKQGSKVIFGVPKPGKKRKFMDVSKHYVSEASTKTQERKEPVKPVRSIVPQNSGIGSWKMPSKTISIEKQTTISRPKTFKPAPKPKEKPGATARIIPRKDSRNTTASDMESDESAENRGPGSGVSFKGTVEEQTTSSSHDTGSKNSSSLSTNKGRVAPTAGRLAKIEEDKALAENSSKTSEGMEPRRSIRRIQPTSRLLEGLQTSMMTSKIPSVSHSKSHLSQSKK
The following text describes a protein:
Function:
Vesicle trafficking protein (Probable). Functions in uterine cells to promote basement membrane (BM) mobility and BM gap formation during tissue remodeling.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MLVSPTAAATSIEQQTIRDLRSIVPQIDNLNDGYVLRWLRAKEGRFDETAESLKKHVTFRNAWHLDKIEQWTPPECLEKYCGYGLLGDTEGRPILMSLLGNVDVEGLLRSVASLDYIKFSLAAIEKGMKLCEEKAKESGRPFEQMTLVFDLENITSAHFSCKQFASSFTTLVSLFQDHYPLFLRKILIIRAPEMARIAYASITAILQDPITRLVEMPSESDWKWSLAQIVNLDAWPMYWGGNLVENGDPKCPSRIKYGGGAVDESYFVDPKKAMADYDQLTTVYAGDKHLIQIKVKRPSRISWTYMTDEDDIGFEIHYDKTGSCDKLTEMETVYPYIRLECTNVPITGHLDVTDVGNYVLEFDNYYSWFSAKQLRYNIEIEDL
The following text describes a protein:
Function:
Member of the two-component regulatory system ArsS/ArsR that regulates genes involved in biofilm formation and acid adaptation by acting on major ammonia-producing pathways. Upon phosphorylation by ArsS, functions as a transcription regulator by direct binding to promoter regions of target genes including ureA, amiE and amiF to positively regulate their expression in response to acidic pH. Negatively autoregulates its expression.
Sequence:
MIEVLMIEDDIELAEFLSEFLLQHGIHVTNYDEPYTGISAANTQNYDLLLLDLTLPNLDGLEVCRRISKQKHIPIIISSARSDVEDKIKALDYGADDYLPKPYDPKELLARIQSLLRRSHKKEEVSEPGDANIFRVDKDSREVYMHEKKLDLTRAEYEILSLLISKKGYVFSRESIAIESESINPESSNKSIDVIIGRLRSKIEKNPKQPQYIISVRGIGYKLEY
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome; Forms part of the polypeptide exit tunnel.
Sequence:
MANLPILDASGKEVGQYEIDTEQIANRVSKQLLHDVVVMYQANKRQGSHNTRTRGQVSGTNKKMYRQKGTGNARAGSKRTNVRRGGGVARTVKPRDYSYRLPKKAIKIATRMAIRSRIDDGEIVVINELKLDAPKTSQIAQILKNLGLANTTTLIATAGDDQIIYKSGRNISGVTVEPVRQLNALTLLTPKRVLFTQEALDRVKDGTFAGSTQNTNEAEAAA
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MAGDLNLKKSWNPALVKNQQKVWEEEQQKLDELKRIKERNQEYKQEQEYLELLKLQHGDQFQIKDLNKQQKLKISKLNWMYDDVPFEGNEKVEENSSGFIESNVEFTDGKSKVENLLKGNHVVGKKRDGSGTSDRINKIIGVGMTKSSKVSYSDDPLLKIKQQQQQAQRVARKQHPSDKHSHRSRHSSKSSSDRVHKSHEHERSRKHNSSHTRHKDGSPHR
The following text describes a protein:
Function:
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released (By similarity). Main acetyltransferase responsible for alpha-tubulin 'Lys-40' acetylation in germline cells during the early stages of oogenesis. Required for normal egg chamber separation.
Miscellaneous:
MISCELLANEOUS: In the ovaries of mutant flies lacking expression of this protein the plasma membrane barrier between germline cells and surrounding somatic follicular cells is compromised, allowing cytoplasmic material to leak from one cell into the other, thus the name leaky.
Subcellular Localization:
Midbody, Midbody ring. Note=Localizes to fusomes in germline cells during oogenesis.
Sequence:
MVEFAFDIKHLFPQSIIRVQAHSLRPKVTQCRRYAQTERGKSTMTSCRLSEILNIMGKLSADAQGLCHAVTSADKLASDQVVYLMADKAAGHWEITGLLKVGTKDLFVFDQGGCYRRLNQTPAILDFYVHESRQRCGQGKLLFEWMLEKQGWSAHKCTVDRPSNKMLAFMAKHYGLVRTIPQGNNFVLYEGFFDDPITTCKSASGLQATGSGCRSRSQGHYVRQEQDQAQIKHGQANRNTVQNDANSGPFRQDQKIVVGTSIYRRRWKSPRTLARAGCREVSGGRRF
The following text describes a protein:
Function:
Unidirectional NADP(+)-dependent cortisol dehydrogenase (in vitro).
Subcellular Localization:
Secreted.
Sequence:
MEERGQGLEGASSANKGPAGEMGVAVGQAVRQAVPAILSPAADPADSEPAMKVLLLTGLGALFFSYYWDDNFDPASLQGARVLLTGASAGVGEELAYHYARLGSHLVLTAHTEAFLQKVVGNCRKLGAPEVFYIAADMASPEVPGRVVQFALDKLGGLDYLVLNHLGATPAGTRSRSIQGTRWLLQVNLLSYVQLTSLALPSLTDSRGSLVVVSSLLGRVPTSFSSPYSAAKFALDGFFGSLRRELDVQDVNVAITMCVLGLRDRASAAEAVRSSTSPLSPLPLPELPGRRSFVFPEGSPPSSRPRAATPIETPLSRWPRPEPESSRQKRKTEKNLPAPGKSRSSEFASADRVPGTWSPTWKAFPQSSGPLWVTWLLLPFCR
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.
Subcellular Localization:
Cytoplasm.
Sequence:
MKTKVMRLDENNIDEHVISEAGDILRQGGLVVFPTETVYGLGANALDKNAVKGIFQAKGRPQDNPLIVHISKMKDIEKLVQKIPSVAEKLMDKFWPGPMTIILKKKDIIPNETSAGLDSIGIRMPSNKIAMKLISMAGVPIAAPSANLSGKPSPTDVETCIEDLDGKVNIILGGDNSEVGVESTVIDCTINPPCILRPGGITLEMVKEVDSNIYIDPAIMKKPDKDLKPKAPGMKYRHYAPKAPLKIIKGDLNKTIEKINEMVQNYIDAEKKVGIIATDETIDNYRKGDVVSIGSRKDLNTIAHNLFYVLRSFDEKNVDLILSEAFEEKDMGVAIMNRLKKSAGYDIINLD
The following text describes a protein:
Function:
Member of the two-component regulatory system TorS/TorR involved in the anaerobic utilization of trimethylamine-N-oxide (TMAO). Phosphorylated TorR activates the transcription of the torCAD operon by binding to four decameric boxes located in the torCAD promoter. Box1, 2 and 4 contain the DNA sequence 5'-CTGTTCATAT-3' and box3 contains the DNA sequence 5'-CCGTTCATCC-3'. Phosphorylated as well as unphosphorylated TorR negatively regulates its own expression by binding to box1 and 2.
Subcellular Localization:
Cytoplasm.
Sequence:
MSYHVLVVEDDLVTRSKLSGYFQNEGYQVTEAESGAQMREALELNDIDLVLLDINLPGEDGLLLTRELRSQSEIGIILVTGRTDSIDKIVGLEMGADDYVTKPVDLRELQVRVKNLLWRISLAQRERITDKHDDKLVHFGEWTFDVQRRALSRNGEPVKLTKAEYELLVALSSYPNQVLSRERILNMISHRVDAPNDRTIDVLIRRMRAKMEMDPKNPQIFVTVHGEGYMFAGD
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
Sequence:
MENYIVSARKYRPSTFESVVGQRALTTTLKNAIATQKLAHAYLFCGPRGVGKTTCARIFAKTINCMTPTTDGEACNECESCVAFNEQRSYNIHELDAASNNSVDDIRQLVEQVRIPPQIGKYKVYIIDEVHMLSASAFNAFLKTLEEPPRHAIFILATTEKHKILPTILSRCQIYDFNRISVEDTVNHLSYVAAKENITAEPEALNVIAMKADGGMRDALSIFDQVVSFTGGNITYKSVIENLNVLDYEYYFRLTDCFLENRVSDALLLFNDVLNKGFDGSHFITGLSSHCRDLLVSKDAATLPLLEVGASIRQRYQEQAQKCPLQFLYRAMKLCNDCDLNYRASKNKRLLVELTLIQVAQLTTEGDDVSGGRGPKQTIKPVFTQPAAAQQPQVASATSAQQTTVHTAPSPATAPSAANTAVRQPQVSVASGAAAPVNTASAPSQSAGISSISKEERKIPVMKMSSLGVSIKNPQRDQAAQNTAKNNVAQVQIQPEEDFIFNDRDLNYYWQEYAGQLPKEQVAIAKRMQVIRPVLLNNSTTFEVVVDNEIAAKDFTALIPELQTYLRGRLKNSKVAMTVRVSEPTETVRAVGRVEKFQMMAQKNQALMQLKDEFGLELY
The following text describes a protein:
Function:
Intercellular signal essential for a variety of patterning events during development.
Subcellular Localization:
[Warthog protein 1]: Secreted. Cell surface. Note=Also secreted in either cleaved or uncleaved form to mediate signaling to other cells; [Warthog protein 1 N-product]: Cell membrane; Peripheral membrane protein; Extracellular side; [Warthog protein 1 C-product]: Secreted, extracellular space. Note=Also secreted in either cleaved or uncleaved form to mediate signaling to other cells.
Sequence:
MMVMNPLTATFLAALIGTAASASCGSSGIPFRFEVLPSGQPVLGCGSPTCFGAENGGRDLRHDSSFMAGADGDDGFFRDGDLARVRVRDPDAPAQMANCPREFSSSSCSNPMTWVGGFKASDNGDLSLQCCHYEGLRFAQEVGRPVVHPGEVYSGGEVLRDGRQTGFDAISNVRKITSGDGTVAYEVTVTRMNCLPNPGEESNEVSFDIQRDIGRILDKVGETAASGVQTNHIEADQRLSPSTDVQSDSYVSPTEADPQEPVEQFVQVGEQVVPVTSAGYYYPVASGVPACFTGNSKVMTPAGEKSMADLSVGDMVMTYEYGKMTYTRVASWLHRLPDTKAAFIKLTTEQGAIIDMTPQHFIYKANCVTEEMELVYAEDMTIGDCLMVKENEKLVMTTISEKSTFYETGVYAPMTETGDLIVDDVYASCHNVVKANTLSHTFLNFATSVQQKMRSVLGSLEETGHLPATSEFFLNIIDVLLPHKY
The following text describes a protein:
Function:
Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions (By similarity).
Subcellular Localization:
Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles (By similarity).
Domain:
The RRM domain is required for the formation of the ASAP complex.
Sequence:
MDLSGVKKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRRSASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSPSRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGKIKMIDMPVERMHPHLSKGYAYVEFENPDEAEKALKHMDGGQIDGQEITATAVLAPWPRPPPRRFSPPRRMLPPLPMWRRSPPRMRRRSRSPRRRSPARRRSRSPGRRRHRSRSSSNSSR
The following text describes a protein:
Function:
Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.
Sequence:
MPVQAFWGTVFETPDRHTLNIIRNALVVVHNGTIEQVIDPATDAATYASVLEAASAAGHLTRLQKGQYLIPGLIDLHVHAPQWPQLGMALDKRLDTWLQQYSFPLEARYKDLVFAEKSYSSLVSALLANGTTTVAYFASIHLEASLLLARICLEKGQRAVVGRVAMDLADQCPEYYRDASPEESVAQSEDFVQQVRGLKGNTEGLVLPSLIPRFIPSCSDAALRGLGELAKNYGCHVQTHCSESDWEHNHVIERYGKHDALALDDFGLLTRRTVLAHCNYLSTEDMQLVKARGAAVGHCPLSNFYFSGAVFPLKKALDMGVHVGMGTDISGGPSASLFDACRYALAAGRALESGTDPCLSATERSQHSGARVSSVEAFFVATANGGISLDLKVGRIAPGYMFDALVIDTTLPNSSLIIFEGIDTLEDVFQKIVYNAAPHNILQTYVNGRLVSQH
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MRREISILVQPRCLLLFISLSILLIFAFSGAKREEEKIVEEEHEITHRVYLDVDIDGQRVGRIVIGLYGEVVPKTVENFRALSTGEKGKGAKGKALHYKGTPFHRIISGFVVQGGDIIHGDGRGSESIYGGTFADENFKIKHSHAGVVSMANSGPDSNGSQFYITTVKASWLDGEHVVFGKVIQGMDIVYMIEGGAGTYSGKPRKKVIIADAGEIPKSKWDEEA
The following text describes a protein:
Function:
Cell wall formation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSAASPLRWQLIEHAPLRALNTFHVDATARWLLNIHAPEALPDALAAPQIAGQPLLVLGSGSNVLLAGDPPGCVLCFDNRDITIIAHHADHAIVRAGAGVNWHGLVMYSLQQGLSGLENLALIPGTVGACPIQNIGAYGAQVSDFIHVVEAYDRGTEQFVRLNPAECAFGYRDSVFKQQPDRYLIVAVEFNLPLLHELRLDYAGIRDELARMGAELAGAADVAQAVINIRQRKLPDPEVLGNAGSFFKNPLLPSEQIAALQASFADMPVFPGEQPGQGKLSAAWLIEQCGWKGKREGDAGISEAHALVLVNHGSASGAQLLAFARQVAESVRERYSVILEPEPRVIGAHW
The following text describes a protein:
Function:
Reticulophagy receptor required for autophagosomal sequestration of endoplasmic reticulum (ER) membranes during ER stress (Ref.5). Confers resistance to ER stress by promoting the autophagic degradation of the ER (ER-phagy or reticulophagy) (Ref.5). Acts as a bridging molecule to mediate the association between atg8 on the autophagic membrane and the vesicle-associated membrane protein-associated proteins (VAPs) scs2 and scs22 on the ER (Ref.5). May play a role in meiosis.
Subcellular Localization:
Endoplasmic reticulum. Preautophagosomal structure. Note=Accumulates at the preautophagosomal structure when autophagy occurs.
Domain:
The atg8-interaction motif (AIM) is required for the association with atg8; The FFAT motif (AIM) is required for the association with the vesicle-associated membrane protein-associated proteins (VAPs) scs2 and scs22.
Sequence:
MNNPFKDMDCYEILQVNHDSDLQEIKANYRKLALQYHPDRNPGIEDYNEIFSQINAAYNILSNDDKRKWHEKDYLRNQYSVQIEDVLQHLQTIEKIPFESTSAFVERLRQDEKIAGSTDDLPTLGDTTWLWTYAKPIYQKWLRFSTKKSFEWEALYNEEEESDAATRRLMKRQNQRQIQYCIQRYNELVRDLIGKACDLDPRRKNVVKLSDGERYNSLQEASRKQSERDRRQYQETFKNQSIASWTIIDQEETSSDDESLSKEIVNSNPIMCMVCNKNFRSQNQLENHENSKKHKKNLRKMNQEIKKHAKEAQKNAESNKQPEDAPSESPYSNKVSSSDFYTRSFEEIEKTFTFVEISDNEFYTASEDGFLNEDDKLDQD
The following text describes a protein:
Function:
Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
Subcellular Localization:
Nucleus.
Sequence:
MANVKKAKFGDFSFGDERKEDEPSAKKKRKSRWANESESEKSILNGLPTKVPMVQLQIEEITRRLRTGELGIPEDVSRRSPSPQPEYGPDGKRTNTREVRVRRKLEEQRHIIILKVQKANPEYKPPMDYKAPNIKIIDKVFIPQDEHPSINFIGLLLGPRGNTLKQLVKETGAAIIIRGKGSVKEGKLGYKTLPGQDEPLHAYITSNDPDCIRQIIEEGIAVPDIENELRKQQLRELALLNGTLKEGDALSKLKQIAEAQTIVTNTIVCALCGGAGHITQDCKQKNGNVGDESSAPVSSSNSNSSDAATPSVMSQFCSSSTFTNYGNLDNEYLSLMAELNQTSSSSDSSSSKNKNNNNNPIVKNMNNNMSNINNNNNILPMNPLVLPPPRFHPVPPPFDSPSNNLAPGWPAPVLPLPQGPPVITPPAPLATPPQPPFYSWITKKLQNKENNDENNNSSSNSSMNLPPLPPWGPAGFCPPPPPFFPPFVPPFMGPPVPPFCGPSIDPNNPATNNNINNNSSSNNICDPNMPLMMAPPQMTNAPQHQQHQQHQLQQHPSINNNNMQQQLHHRPPNVHHHQQQQPQQHQQFRHQQLQQQRHQFHQQQQQQQQQQQHRHRNQQQQQHHDEEYSEYNGNYEHDNDYEGNNYEDGDYANDYDNNDNGHNNGNYDNNNYNNNNNNNNGDYYYSRHHHHQSIPSSPPLPSSPPPSSSSWQPPPPPSDDYYDIPPPPLPPF
The following text describes a protein:
Function:
Involved in olefin biosynthesis. Catalyzes the conversion of 2-alkyl-3-hydroxyalkanoic acids to beta-lactones in the presence of ATP.
Subcellular Localization:
Cytoplasm.
Sequence:
MGDNGRMTTLCNIAASLPRLARERPDQIAIRCPGGRGANGMAAYDVTLSYAELDARSDAIAAGLALHGIGRGVRAVVMVRPSPEFFLLMFALFKAGAVPVLVDPGIDKRALKQCLDEAQPQAFIGIPLAQLARRLLRWAPSATQIVTVGGRYCWGGVTLARVERDGAGAGSQLADTAADDVAAILFTSGSTGVPKGVVYRHRHFVGQIELLRNAFDMQPGGVDLPTFPPFALFDPALGLTSVIPDMDPTRPATADPRKLHDAMTRFGVTQLFGSPALMRVLADYGQPLPNVRLATSAGAPVPPDVVAKIRALLPADAQFWTPYGATECLPVAAIEGRTLDATRTATEAGAGTCVGQVVAPNEVRIIAIDDAAIPEWSGVRVLAAGEVGEITVAGPTTTDTYFNRDAATRNAKIRERCSDGSERVVHRMGDVGYFDAEGRLWFCGRKTHRVETATGPLYTEQVEPIFNVHPQVRRTALVGVGTPGQQQPVLCVELQPGVAASAFAEVETALRAVGAAHPHTAGIARFLRHSGFPVDIRHNAKIGREKLAIWAAQQRV
The following text describes a protein:
Function:
Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
Subcellular Localization:
Cytoplasm.
Sequence:
MSQLDLNALNELPKVDRVMALAETNAQLEKLSAEERVAWALENLPGEYVLSSSFGIQAAVSLHLVNQIRPDIPVILTDTGYLFPETYQFIDELTDKLKLNLKVYRAGESPAWQEARYGKLWEQGVEGIEKYNEINKVEPMNRALKELKAQTWFAGLRREQSGSRAHLPVLAIQRGVFKVLPIIDWDNRTVYQYLQKHGLKYHPLWDQGYLSVGDTHTTRKWEPGMAEEETRFFGLKRECGLHEG
The following text describes a protein:
Function:
May be involved in the regulation of cell differentiation.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MARDKEDQNNENPSIVQNMSFPFNTIFLISSAIFLVTAAFWFVAVMTLHYRTDECNRFVTTPGIFISFSLLAMSLTGFYAAYFKSDCLFRIHFFIFFLWMFVVVSKAIFVIFLHKETNPRLFPGTKIYEFRYEDYSGWVSRLVIKDDEWYRTRRCLVKDNVCNRLNHKMPASEFYQMNLTPIQSGCCKPPLSCGLNYEKPNNWTVSRYYNNLEVDCKRWNNSADTLCFDCDSCKAVIIADVHNTSFSITVNIIHIIFSLCIGMTGWFAWLRILRESQK
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Miscellaneous:
MISCELLANEOUS: Present with 2430 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Sequence:
MISDEQLNSLAITFGIVMMTLIVIYHAVDSTMSPKN
The following text describes a protein:
Function:
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity.
Subcellular Localization:
Nucleus.
Sequence:
MSNTMAFSAIAVIPGKSVKVFGKAIQCLSKVGDELYVQINENGIDLRTVNSSRSAYSRMEFKSRFFSTFRVRESDSGGSDSILKCKINMKPCLNIFRSSSTDKNVNSCSITLDGNENRLKFLLECRFGIRKAFDLLLQDCESLEAMFTKDDCPNAIVSLPKIFSNTICNFHASQEEITLVATKENIIIKNYVEDQAELIKMLYTEMNLATHEFLSYDVKTEGDITFCLKEFRAIVSFGEYTGQPISMHFESAGKPIMFHIAKENTFTADFVLASLVDTDTPSQRSNAFHQNTTNLDDSHCHIIEDSILEKSNLEDDSATQDKRSSAHLAQITQKSNEEEGRRYFSNGYRFRGRRVIDFLSWIFCGSQYLHDRRG