lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Vacuolar Fe(2+) uptake transporter.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Domain:
The cytoplasmic metal binding domain (MBD) is located between transmembrane 2 (TM2) and transmembrane 3 (TM3).
Sequence:
MAATEHRLSLEPEKKNLLRHHTEKHFTAGEIVRDIIIGVSDGLTVPFALAAGLSGANATSSIVLTAGIAEVAAGAISMGLGGYLAAKSETDHYARELKREQEEIIAVPDTEAAEVAETLAQYGIEAHEYAPVVNALRKNPQAWLDFMMKFELGLEKPDPRRALHSAMTIAIAYILGGVVPLVPYMFIQKAAEAVVFSVVVTLVALLIFGYAKGHFTGNKPFRSALETALIGAIASAAAFGLAKAFNP
The following text describes a protein:
Function:
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. CUL2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase.
Subcellular Localization:
Nucleus.
Domain:
The Cullin neddylation domain restrains the RING domain of RBX1 in the E3 ubiquitin-protein ligase complex; this restraint is removed upon neddylation of the cullin.
Sequence:
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYAETKIFLESHVRHLYKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQYIKKNKLTEADIQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQNILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQGIFVSPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHSECHSIIQQERKNDMANMYVLLRAVSSGLPHMIEELQKHIHDEGLRATSNLTQEHMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDKLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIRNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMSFSSKRTKFKITTSMQKDTPQELEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA
The following text describes a protein:
Function:
Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
Sequence:
MKLKEVTEGKVRIFVPDPTGYMVEGKFDPSWAPVFYNPKMTFNRDLSVIVVSILKPKIIVDALSATGIRGIRYYVESWKSEQLILNDKNPNATSLIQINAKNNGIENAKIYNKDANALLYEVKSDYIDIDPFGSPAPFILSSLNAATRNGIVAFTATDLSPLEGSSPTSCRRKYDAINHKLSSSKELGLRVLIGKIIREAAILEKTVYPLFSFYADYYYRLFVRVENGARKADDNINKHLKYFGECPRCGFQTFVEENCKTKCPVCGEIFSIIGPLYIGPLYSMEFLKRIMDLYSNFNYLTSFNRIQKLLNVIEKEARFKNVFYNISKLASKLKISAIPPIESILECLGDASRTHFAPTGIRTDKEYEEITKCIKSLR
The following text describes a protein:
Function:
Binds heparin.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MLLPGRARQPPTPQPVQHPGLRRQVEPPGQLLRLFYCTVLVCSKEISALTDFSGYLTKLLQNHTTYACDGDYLNLQCPRHSTISVQSAFYGQDYQMCSSQKPASQREDSLTCVAATTFQKVLDECQNQRACHLLVNSRVFGPDLCPGSSKYLLVSFKCQPNELKNKTVCEDQELKLHCHESKFLNIYSATYGRRTQERDICSSKAERLPPFDCLSYSALQVLSRRCYGKQRCKIIVNNHHFGSPCLPGVKKYLTVTYACVPKNILTAIDPAIANLKPSLKQKDGEYGINFDPSGSKVLRKDGILVSNSLAAFAYIRAHPERAALLFVSSVCIGLALTLCALVIRESCAKDFRDLQLGREQLVPGSDKVEEDSEDEEEEEDPSESDFPGELSGFCRTSYPIYSSIEAAELAERIERREQIIQEIWMNSGLDTSLPRNMGQFY
The following text describes a protein:
Function:
Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites. Affects intestinal epithelial permeability and adaptive immunity. In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells. Mechanistically, exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG. Receptor stimulation results in the rapid activation of JAK1 and JAK3 kinase activities leading to STAT1, STAT3 and STAT5-mediated transcriptional programs. Induction of differentiation genes seems to be mediated by STAT1 alone, while protection of cells from apoptosis depends on STAT3 and STAT5.
Subcellular Localization:
Secreted.
Sequence:
MLLAMVLTSALLLCSVAGQGCPTLAGILDINFLINKMQEDPASKCHCSANVTSCLCLGIPSDNCTRPCFSERLSQMTNTTMQTRYPLIFSRVKKSVEVLKNNKCPYFSCEQPCNQTTAGNALTFLKSLLEIFQKEKMRGMRGKI
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Subcellular Localization:
Cytoplasm.
Sequence:
MCEAEEGDCGGGQLWRPLQRSRPLKCMKCKEGSPVLIIRVGDAFCKTCFKEYFIHKFRATLGKNRCIYPGEKVLLAFSGGPASSSMVRQVQEGLSQGAAKKLRFKPGIVYIDEGAVCGQSLAAREDIRNEVETILEATGFPYHLVHLEEVFDLPSSVLHSVSREIPDQSNSYKEAVDDFIKQQREKERDTAELSLRDQQGELSLQDASREEELIDPRKEMPAVSHTEKLINLFQTVKTLTAKEELLQTLRTHLILHVARTNGYGKVMMGDSCTRVAVKLLTNLSLGRGAFLAADTGFSDNRHGDVLFLRPMREYPAKEIAFYNRLFGVPSVFIPALDTKASERASIHRLIESFLYKLQSEFPSTVSTVYRTGEKLSGDAGGLSEPARCLFCLCLLDTNVVDGSSLQSTLLSEQLCKKGTPLSPGVDGCCGGTGDRAGCCQRPIVTRDSSPHTQLLPFLCYSCRLTAKDMNSLESLPPYIQSEAEHRQCRAAMKLEIQEFLLEDDPETS
The following text describes a protein:
Function:
Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. Possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of seven or more carbons in length). Appears to be the acyl-HSL acylase that underlies the ability of P.aeruginosa to degrade and utilize certain acyl-HSLs as growth nutrients, including one of its own quorum signals, 3-oxo-C12-HSL. Is thought to have a role in quorum quenching.
Miscellaneous:
MISCELLANEOUS: AHL-mediated signaling mediates quorum sensing in many species of Proteobacteria, regulating hundreds of genes, including many that code for extracellular virulence factors.
Subcellular Localization:
Periplasm.
Sequence:
MASPAFMRFLPRCGAAAAFGTLLGLAGCQSWLDDRYADSLPPTSGVQPIKGLAQNVSIRRNALGMPLIETGTFHDALFALGYVHASDRLSQMVSLRLLAQGRLAEMVGPGALEIDRFMRTVNLRQAAEIQYRNASPRLQRFFEVYARGVNAYLYRYRDKLPMDLAQSGYRPEYWKPEDSALVFALLNFGLAVNLQEEIASLTLAQKVGSDKLAWLTPTYPDENLPFDEAEKLKGLRLDGQVPGLAGVEGAARQVAALSMLGVAASNNWAIAPQRSRSGKSLMANDTHLPLSMPSVWNYVQIRSPKYQAAGVSIAGLPGVVAGFNGKLAWGMTMVLGDNQDLYLEQLRRQGNRLYYLADGKWQPTRERQETFFIKGQRPIREVIHETRHGPLLNSALGERKNILQPLPLKSGYGLAYRSIQQEADKTLDGFFDLSRAKTIEQAFDATREIRAMPLNIVFADEKHIGWQVTGRYPNRKEGRGLLPSPGWDGRYDWDGYADPILHPSDQDPQQGWLGTANHRTVQPGYGAQLSNSWYYPERAERIAQLAGASKSHDTQSMIRMQYDQTSLFVAKLQAMFDNPGMALPLRQAIDALPEAQRSRAREAYDRLMAFDGKLTASSSDAALYGAFLHESARQIFLDELGPEDGPAWKAFVETANLSYSAQADHLLGRDDSPFWDDTRTPQKEDKPAILARSLAAAVEFCEQRLGSERKAWQWGKLHTYEWQSDSSKMAPYLGAGERAGLGAIKGYLDRGPYPAGGDHTTLDVSAYGWGQDFDTWLIPAMRLIVDFGQSEPMIGVNSSGQSGNPASPHYADGIDAWLKGRYVSFPFQPQNLDRVYGNKRLTLTPAR
The following text describes a protein:
Function:
Involved in the degradation of pyridoxine or pyridoxamine (free, phosphate-unbound, forms of vitamin B6). Hydrolyzes 4-pyridoxolactone to 4-pyridoxic acid. Has lower activity toward N-hexanoyl-D,L-homoserine lactone, but is not active toward 5-pyridoxolactone and gamma-butyrolactone.
Sequence:
MSDTKVYLLDGGSLVLDGYHVFWNRGPGGEVRFPVYSILIEHAEGRFLIDTGYDYDHVMKVLPFEKPIQEKHQTIPGALGLLGLEPRDIDVVVNSHFHFDHCGGNKYFPHAKKICHRSEVPQACNPQPFEHLGYSDLSFSAEAAEARGATAQLLEGTTRANSTFEGIDGDVDLARGVKLISTPGHSIGHYSLLVEFPRRKPILFTIDAAYTQKSLETLCQAAFHIDPVAGVNSMRKVKKLAEDHGAELMYSHDMDNFKTYRTGTQFYG
The following text describes a protein:
Function:
SNARE promoting movement of transport vesicles to target membranes. Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking. Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Recycling endosome membrane; Single-pass type IV membrane protein.
Sequence:
MSMEDPFFVVKGEVQKAVNTAQGLFQRWTELLQGPSAATREEIDWTTNELRNNLRSIEWDLEDLDETISIVEANPRKFNLDATELSIRKAFITSTRQIVRDMKDQMSASSVQALAERKNRQALLGDSSSQNWDAGVTDRYGRLDRELQLANSHFIEEQQAQQQLIVEQQDEQLELVSGSIGVLKNMSQRIGGELEEQAVMLDDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQWCAIAILFAVLLVVLTLFLVL
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MNVLLIAILIDSMMMSHVFTQSVIYSTQFQQDGRYSVSPISPDNRMLLQQQDRLLHPNFFVTASAVVRPDTVYRVDFVVLPGAPDLVFKALITKGSGQHVTSASSDSVDAGTIESSPAQSAFSLSLKHHILWQLILLDSTTEIHTNVQIPASISAGDYRLKLEPQLGYDVQHPQKAVLIKESPLRFRIILTQMDLKPYTDPITIFILDPQGFIVRRWPSRNPTNGVVSLTYQLPPNPSVGARRSASIRVEAMQQVHQHQFGVEHYYIPFFVVVPSAPAYVLLRDLLSPHAIRRQWQSDRSRLRQASQQYDGRLPTCCRRTFSMEQNHEFTYDVNLGDVKSAIRSRSLDSWVIRVTTVLHSYFMGEARDGFIETRVIHAQLKFKFSGAKTAVFKPGMPFEGHVYFMYDDDQALTSDKLAGATITLRPVVTSTNGQMKTLSEIKVPAKGEYLNHHQQEDGNKYRKEYDNWMEHQIEDVKFNQFRATGVYNFRFSVPKDAKSMRISATYKDGDGDKATAELQAVPFYSAKEMYAHVETSTEYGQLGENVVIHLRSNFGFQVYSYVECGRHQLEFVLSRRSGSKILTIGGAAILATVGGSVVLAKTSDGFRKFSEKNIPGTSFLFNLLLGPSVSHLPKLEHPVKVKEDGLLKKKLEREALKKKDEELPINPVEESSLQELPISLIDLPPPDFDVIKSVEEFCENDQSSVEESLNLDPEVKTDENIKVANESEPDSSAVEVLEKVSVNLSELTAAEFGDLLKELHAKASDAVKEAVAAQDMAACSIKKHVELVFKSLEKIYEPGQTHENIWEPVFMATHDKNEAVHVAESRAHDARMAVAQLKEAVAHGLKNDQSIQTPDLITFDESVARALYSLETAKARVEAAQSEAKVMDEYRELVDTARHNLQMELSSIRPELAPSFKTEGSKLGEEEINILMAHAYWKIITLQKELARQQSCEQQRLKGALDTQRKEDHSVLESRLRVELERQYYELKAKYNQDISFHEKTLSDQFTQQLKLQAAAYTDHLNDTLKTQRLELKRTFDAERELEVAKLLASHHENLAKLHGMGKGIQDAIHDRAEKDRVSRQVRELWIAAQSMIESLRSNNSVHLPWNEQRHPLNLSSLNKALNNNDEFARAVIESIPPTALDQGILPQGALKERFLNVERVCRRVALIDENGGSILRYALSYLQSMMVVKVDARPQSKDEEINLADLNTFDILARTRYHLEKDDLEQALRYMNLLKGEPQNVANDWLRELRIHLETVQAVNAILTYAAVQAIESM
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Sequence:
MEKGKSDQDDHVVRKLNRQISNSTTRNPYAGEPFRSGGGASPSLDPILSDEAKNSTSSNLSDPSNTQDVKCPLVQEANSGNHRRASTMTAGQDALNSPDDRSLASAFKAMSFKKRIEFDLTIPSFEHNPASFRYAVLHNSEHLNKSSSMPESSEMPIRMPTMPNGVDLPNLEAKGYSSFITRDDSSMCNRTLDGHCDASSCKLNFCAPRYQTPNSVLACHNEQWQSYTGYPSDMPVNPGKQTFSSPGVLAQGFQLPTTFLNQDYVDAPSHAYASYCQQNQPNVGWCDFEDERNYINNSQYLYFQQLENQHLEGHVQRGRNSATGHLSGCSTQPYFHMPIPHQAGLAYPNSYESDDVANSRCNQLYDILPSRNHGRYHRNGYPSFSNSSVVPQRLKLSSHSGSTVSSHGDQVPDFFCKLTSHGVNPLRTSIGSHQLPKHADNTSRMFPDDGANSYNGRRDGSLNLGIQRSLSSSSDGSDQRHDPESSHLQYDSLDNLSGRIHMLAKDLCGHCFLLKTLDKRERGNVDKIFVEIISHVAELMIHPIAHHLIKKLVEVCTEQQLTHITDKISERTDQLPRICCDQHGTSVVQKIIKTVKSPELYFNIAEALKPGILSLMKNINGSQVAQYCLRYLPPESKEFLFDVAVANCIELARDRQGCCVIQKCLSDLEGEQKNDLLFKVTSKAHALSQDPSGNYVVQLILDQQIPWATSRILDQLEGHYGTLSVQRYSSNVVEKCLKLVRDDQCDNIIRELINDPCFVQISQDPFGNYVVQTARRACKGELIIAFLEAIRPHIAELRASSFGRKVLSKTYHNG
The following text describes a protein:
Function:
Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiV, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.
Sequence:
MELLCPAGNLPALKAAIENGADAVYIGLKDDTNARHFAGLNFTEKKLQEAVSFVHQHRRKLHIAINTFAHPDGYARWQRAVDMAAQLGADALILADLAMLEYAAERYPHIERHVSVQASATNEEAINFYHRHFDVARVVLPRVLSIHQVKQLARVTPVPLEVFAFGSLCIMSEGRCYLSSYLTGESPNTIGACSPARFVRWQQTPQGLESRLNEVLIDRYQDGENAGYPTLCKGRYLVDGERYHALEEPTSLNTLELLPELMAANIASVKIEGRQRSPAYVSQVAKVWRQAIDRCKADPQNFVPQSAWMETLGSMSEGTQTTLGAYHRKWQ
The following text describes a protein:
Function:
Member of the two-component regulatory system YrkQ/YrkP. Probably activates YrkP by phosphorylation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSSEEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIYSESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLIIVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKLKAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKALQLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPETYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPESNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Sequence:
MFHEKPDKLLLSSIESFEIEPDLLTLRRIEEVINKTNQYRSNTIENYETKLNTMKSEFQSLMSEINLLTKVSGINYENLKLLGNGNEESMGDLSNKNIFNVMNEKSIELDNLKLSLAKNLNDLESQINSMNITKKDLMEKYELVKMKNDNLINDNILKNPDSKAIKINIYKNLGVEIESGEEGETENKQDKVIIYNKETNLSSILNIDDKYSEYFITNYIWDRLQGY
The following text describes a protein:
Function:
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Subcellular Localization:
Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasm, cytoskeleton.
Sequence:
MGKMRQMEQKYDLSKCHTYNEKSSFAFWVVLVLLFCLALGNLCLTLSITAILRIYRGMENIELIQDADSIKFYGNIDFDRVYKQDGLLESFYDEPLELAGDDGDISINLVNRNGNTHNKIQLTRTGTFLKGINHFDVKDPATGRQVFGTLRPHYNMPQGAMILQAHLVNSGRIAAPINDTLKLQTRNKLTLKGTEGIRMEAKELLWSADQNIFLKSDNGSTMLVGGNGVWVNVNNLPVVKSEHGLRTGSAGQYKLCVCHPQGRIFRMAVPKSHNARVNCAHFSGKENPCA
The following text describes a protein:
Function:
Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
Sequence:
MNATPKFAFDSPEEAIDALSRRIGTTGVQRVEIGESHDSLRSLHRRVLATPILADRDSPAADVSAMDGYAIRESDLLNEGPIEVTGESVPGSPPPSASDTGVIRIFTGAIVPVGCDRVIQREHTDETAPASASDSHSLGQIQWTDQAKSIPAGANIRRQGENLSAGSIAVEAGLELTSPRLAALTNFGVQQVDLHKPVRVAVLTTGDELASGTAPDQSPLPPWKIRNSNASALLGLLTNQPWIDCAPPMHAVDEPAALLTAVQHAIEHHDVVLMTGGVSMGDYDYVPRILREAGAEIVFHKLPLRPGKPILGAVHQSDSKSTLILGLPGNPVSATMGARRFAMPLIRKLAGMTNWEEFPPLVTLEEVSEKTLPLHWLRGVRLTQPGRAALVIGKGSGDVATLAGTDGFIEMPPHANHAGPWPYFAW
The following text describes a protein:
Function:
Telomeric DNA-binding protein, which binds to single-stranded C-rich repeat sequences, with high specificity to the 5'-GCCTAA-3' sequence. Repeat sequence binding can be at the 5' or 3' telomeric end. May have a role in protecting the 5' end of the C-rich strand of the telomere. Acts redundantly with pot-2 to negatively regulate telomerase-mediated telomere extension. Also regulates telomere length by the telomerase-independent telomere maintenance pathway called ALT (alternative lengthening of telomeres). Through sun-1, anchors telomeres to the nuclear envelope in embryos.
Subcellular Localization:
Nucleus. Nucleus envelope. Chromosome, telomere. Note=More highly expressed in meiotic pachytene nuclei than in diakinesis-stage oocyte nuclei. Also expressed in mitotic nuclei.
Sequence:
MQYTYQHIQDLVPGPTPQNFYGKIIFIKKKINQIVVLIKDETQSIYLRVIPKEDQELEFQLRQVVRVHRCKIQSILNSKEGIAQIGLFGCHLIAWSQSGKVDNPVIISSRSWTKSDEDSERLQTLRKLGKSRRKSGRKTSVDTMANKLIERREAMFADTFIKSLFNKIALSRKEHLSRNARELFYHRPGDIVETQNLLEIDDSWFNDENSEQFVQYVLNCTTCHVEYNHVEYAQNNIPTNCRFCQEAMESFHAAFRIRISIETYGVFLTIPLELIKTELDICEDWDSESNIVEEEEKVTRFKKNIQEKVRDASIVHIKGISSLLLIIMLNINSISLVNNITENKRILLQKSNVPSSLQLKILITPFVIVVVRFFGITWIYSGSSCIEEVLNLIDNCSRRR
The following text describes a protein:
Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSKVSSIFDTPAPDPRPATTENGAAAKPAARKKKSPAAATKKQLIDQLIREMSQDEDNNDSVDQAPPAKKSRKKADSSGNNNTSKSSVKDKPAKPKKPKTAGLKIKLQDHRKHKEKLRKSLQGVENSRQAAASTSMLEASFNGDSLKDRSNHSTPVHHKGAKAAKKNKNKSHIMPLPLTFTPSKVVVKQEPKTPRRPTMLNVEASSGSLDSVEIGREKFSWVIGPSTTVDEFMAQFWEKKPFLVQRNDPTYYANLLSRGKIDEMLRNNNIEYTKNLDVTSYREGVRETHNPDGRALPPDVWAFYEEGCSIRMLNPQTYLPGVYEMNVKLQEFFHCMTGSNFYLTPPNSQGFAPHYDDIEAFVLQVEGRKHWKLYSPRTASEVLARVSSPNFTQEEIGVPILEVTLEPGDLLYFPRGIIHQASTVPGHHSLHVTMSVYQKNSWADLLELYLPHALSQAAENHLELRRGIPQDLHQHFGIVHSDNETPTRKDLIKKIKSLVDKIFSEEAIDVAVDQLAKRFQHDALPPLLTDQERAQTAYGANYAFNPDGTVPLQTAFTERTTIRLLRRNIVRLVNEENTLRLYYHTENSREYHEYEPNFLEVDQDAALGVELLVKIYPETVAIGALPVEDKVEFAKSLWEKGLIVARGE
The following text describes a protein:
Function:
Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end (By similarity).
Subcellular Localization:
Secreted. Bacterial flagellum.
Sequence:
MSLGPMGMNTGFDINGMVSKIVSAERVPKQQRIDNERTNIDTSISAYGRLRESLDTMKNLMTQFRQEKAFAVRKVDTSNEQVVSATATTEAIAGNYSVDVLQLAQSHKIASEVLDKDAKFGPGKLHISLGDKSFTLDVQGNSKLVDIVRGINGEKSNPGVRASIINDVEGPRLIVASNVSGKDHSVKMSAQAEPGNPLKQLEYKTLEQRVRDLEKARAQAQQLIAPLTPEQQKVAAKVAEKIGDAARLVDQEVAQEIRSAAQSAQGAAGEALNAGELTESAVKAAANAASEAKKYIRPEDRIPGWTETASGTLLDSYWEPEEELDAQGQKKAADVPGWSNTASGTLLDSYVTPQEAQQKLEQKLAQEKAQIEAAIRSGKMTPEEAKAQARAKLSPEERAYIEQVEKAQAALNAAQSAFDGYGGMTEVQSAQDSMVVLDGVATLSSNNNIIENAIEGVNLTLKGKTDRNQPPAEIGIEYDRERVRNDIEQFVAAYNQFFQTSKELAGVDPRTGQAGPLAGDSIVRSADSRLKTVFSSSIEQAPENLKSLTEFGITTTRQGTLEINYAMLDRQLNNNFTKLGEFFGGNQGFAKRVEDAISSMTGVTGSIRTREKSLNEQTYRLDDDQRSLDRRMESLEKRTHAKFSAMQDATSKMQSQLAGMMNALGG
The following text describes a protein:
Function:
Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MTDRVIVGSNKSPSNPTPLSAPQEQQVRDLYYKNVRAKCASEIESSSLLPPSPIPSHPPLTMPSAAFAQCALGRTFTMIYACRAPRLAMNSCMLQYQNQDELDKARAEWFKLAGERKKAREEHQRRLEDARSKHKEWWNLDESGQLQGKRVEGDVGGRREENRVDERGVTRGGIYRGT
The following text describes a protein:
Function:
Plays a role in the apoptotic process and has a pro-apoptotic activity.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MMKRAAAAAVGGALAVGAVPVVLSAMGFTGAGIAASSIAAKMMSAAAIANGGGVSAGSLVATLQSVGAAGLSTSSNILLASVGSVLGACLGNSPSSSLPAEPEAKEDEARENVPQGEPPKPPLKSEKHEE
The following text describes a protein:
Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MRTPVVMTLGMVFAPCGLLFNLTSTLAPGWRLVKGFLDQPVDVELYQGLWDMCREQSSSERECGQQDKWGYFEAQPVLVARALMVTSLAVTVLGLLLASLGVRCWQDEPNFVLAGLSGLVLFVAGLLSLIPVSWYNHFLRDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGGFSLALSFAPWCKERHKAPSAGPRRSSVSTIRVEWPEPELTPAIKYYSDGQHRPLPAQHRKPKPKVGFPMPRPPPKAYTNSVDVLAGEGWEAAQSQDSTSCSSHPCGSTLPCDSDL
The following text describes a protein:
Function:
Binds specific group II introns in chloroplasts and facilitates their splicing. Acts on subgroup IIB introns. The substrates of the subgroup IIB also require the CRM domain proteins CAF1 or CAF2, with a simultaneous binding of CFM3 and CAF1 or CAF2. May influence the biogenesis of the mitochondrial small ribosomal subunit (By similarity).
Subcellular Localization:
Plastid, chloroplast stroma. Mitochondrion.
Sequence:
MAMASSPACHFRHPPRLRLLLPLSTSAPHPWLYSWSHPRQRGRLRAPPAALDLRPEPSPSSDSDDEDAVGASRSSGRSTMSLILSRLRRAGYSGEDPRAAAPPHPPRGSVEDVFRADDGVLPNARGGFDADDEERALGDARFPWERPMPPPEAAPRSARSPTWMAELTLPAAELRRLRHAAIRIKSRTKVGGAGVTREIVEKIKEKWKTEEVVRVKVSGTPALNMRLFHEILERKTGGLVIWRSGTSVSLYRGVDYDEPEPTKKSKKNSQSLAMDFPIKGSSNPSLLPTETANSVRDSNVALVSNAAKEELVVQAPEIKYEDEIDKLLDELGPRYTDWPGSDPLPVDADLLPANMPGYKPPFRVLPYGVRPSLSRRDTTNLRRLARGLPPHFALGRSRQLQGLANAMVKLWEKSSIAKIALKRGVQLTTSERMAEDIKKLTGGVMLSRNNEFIVFYRGKDFLSSELAEVLLERERLAKSLQDEEEARRKAASYFSSAETYAQPTVAGTLGETLEANSKYGTKHDENHADKMARTIEAARHADLVRKLEWKLSLAQKKMEKAERVLGKVETALRPTEDSRPPETITDEERFMFRKLGLRMKAFLLLGRRGVFDGTIENMHLHWKYRELVKILVKAKSFADVKRIALSLEAESGGILVSVDKVSKGYAIVVFRGKNYRRPSSLRPRNLLSKRKALARSIELQRHQALSRHFAKLNRKVERLKAELVQMEDVKEQGDEELYAKLDAAYSSDDEDMEDEDDEAYLKRFDNEVAGATADDDGSDDYTSAADEADYPDSDDEAGDCSEDEGEDDEDEAAAGVSDAGFHGEVVGFSSDTDRRNHDVNEY
The following text describes a protein:
Function:
Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.
Sequence:
MTDSNETTEQPVKKYAQLLFGPSDAEKSDYIDGFIQYFGEIQRDYILLNLDPTTSIKSEYFRDDIRNDIFETYDYSTHENRYLEYCLNCINEVFESQEWVDRTFNEADCPYFIINFPTSISISINYDEISRIMSYLHEINFNFVCINLIPANCINSPKDVFASFLLTTSTFIEPIIHQCPILNVICGYNLVHDNHAEFIDELAIIPIADMLNKVNEEFSIVEPLSTNIARVFDSFDAFSKLFIFNSHDNQNIKEFVSITDDILECVFEEGEY
The following text describes a protein:
Function:
Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MTLALILCFCDQQARETETWVPSGQPTEESLEDLASGDSPNSSDFAFQAEDDLESYDDDENDDDDDFSGSGDEDFPELHGSSPSNDVVDSSPFPQPDIIDNRIPDQSKPDQPKDNVNENDIVAQNEVGHGRMRPEDVNTNVLMSHSAEESIFNKTEVLAALIAGGAVGLLFAILLILLLIYRMKKKDEGSYDLGKKPIYKKAPTAEIYA
The following text describes a protein:
Function:
Acts as a sodium-dependent hypoxanthine transporter. May show xanthine-hypoxanthine exchange activity.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSRSPLNPSQLRSVGSQDALAPLPPPAPQNPSTHSWDPLCGSLPWGLSCLLALQHVLVMASLLCVSHLLLLCSLSPGGLSYSPSQLLASSFFSCGMSTILQTWMGSRLPLVQAPSLEFLIPALVLTSQKLPRAIQTPGNSSLMLHLCRGPSCHGLGHWNTSLQEVSGAVVVSGLLQGMMGLLGSPGHVFPHCGPLVLAPSLVVAGLSAHREVAQFCFTHWGLALLVILLMVVCSQHLGSCQFHVCPWRRASTSSTHTPLPVFRLLSVLIPVACVWIVSAFVGFSVIPQELSAPTKAPWIWLPHPGEWNWPLLTPRALAAGISMALAASTSSLGCYALCGRLLHLPPPPPHACSRGLSLEGLGSVLAGLLGSPMGTASSFPNVGKVGLIQAGSQQVAHLVGLLCVGLGLSPRLAQLLTTIPLPVVGGVLGVTQAVVLSAGFSSFYLADIDSGRNIFIVGFSIFMALLLPRWFREAPVLFSTGWSPLDVLLHSLLTQPIFLAGLSGFLLENTIPGTQLERGLGQGLPSPFTAQEARMPQKPREKAAQVYRLPFPIQNLCPCIPQPLHCLCPLPEDPGDEEGGSSEPEEMADLLPGSGEPCPESSREGFRSQK
The following text describes a protein:
Function:
Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Vacuole membrane.
Sequence:
MGANTKYSFQNERVQQDGNTGDLRPGHFQPAGSPQGEPMLPTHNEKSARRYGIFRVDTAGESGRSGFHPVHFFAVCFKSTCTLSMLVNILWPFVPAAIAIHFARKDLHIWIFALNYVAMVPSANLLGFAGGELARKLPKVLGILLETTLSSVVEIVLFMVLIHNDRGGNLIPVIQAAILGSILANLLLCLGLCFFFGGIRRHEQSFHEAISEVGSGLLLVAGFGLLIPSAFYAALSSSSTKAIITPEDLDHSTLVISRSTSVILLVAFIMFLFYNLHSHHSIFDEVLEKDEQRDEDREEELQRTKLTLTECLVAIAFSLTFVCMSAVFLVEEIEYIVETGVSDNFMGLILVPLVEKAAEHLTAIDEAWDNQINFALFHCLGPSIQTALLNAPLAVIVGWCLDKDMGLNFEIFMIVLVVLSILVVGNFLRDGKSNYLEGGLCVLVYVIIAVTTWYYPKVEGELGGHSGHPTE
The following text describes a protein:
Function:
Acts as a component of the general transcription and DNA repair factor IIH (TFIIH or factor B), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase activity and DNA-dependent ATPase activity, and is essential for polymerase II transcription (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDDEGARKVDEKCPLCQADRYLNPNMKLLINPECYHKMCESCVDRIFTTGPAQCPTPGCNKILRKAKFREQTFEDAQIEREVDVRKRISRIFNKGQQEFDSLQAYNDYLEEVEILTFNLIYKIDVEETEEKVKQYEKQNRDSIAANSARAAAEARILAQNEILLKRQKQEAREAAIREHQKEKERREQVEQQIIFDLATSGKDPNKIIQLSDSLKKQQENIASSVSNISRSSSILLSDVQQVAEDTTPFSPLAGEKDGSKYFSYSKNTYQDLYLEKVSHEPGRKCGFRIEDCHLRCLYEAFSGIDYDLESLKKLEVAS