lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Purine-specific deoxyribonucleoside kinase that phosphorylates preferentially deoxyguanosine, as part of the deoxyribonucleotide salvage pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MFRRSLMFMISNNKNTNMVSSINTTNKVNNFSKIIILEGNISAGKTYLSSKLGDLLGYKVFLEPTATNPYLSLFYKEPSKYALIMQKWLLNQRYNTFLNALQYSLENEQGVILDRSVYSDWVFAENCRSEGLISAEGFKEYNSIRDRFLSNIPIPNVTLFLDVDPKQCLQRIQNRKRDCEQSIPLSYLSGLDNCYKKFLIEMKSKGSNVIILDWNNFGDINLVLNEINNDNFNNFNNSNNSKFNDVNYKKQQLISDIENEKNNLKEMKFFLNENNNNNNQEKIKS
The following text describes a protein:
Function:
May be involved in some transport function.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFSMSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYIKDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQVEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDNKTNEHMKENRRVEIVIKKSKTTSS
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MVMYELFCITRPAANATRTSSPTLAMNIAKNCGRAILDNKGVVVDVESMGLKELAKPIKKLNQSYSFGHWWSMTFYSNPTVQSEIQRILRLEPSVLRYMIVKKADKLSDLM
The following text describes a protein:
Function:
May act as a component of the auxin efflux carrier.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MIGIKDLYSVLTAVVPLYVTMFLAYASVKWWNIFTPEQCAGINRFVAIFAVPLLSFEFVSRINPYKMDLLFLAADGVSKILILVVLFCWANFSKTGSLDWSITLFSLSTLPNTLVMGIPLLKSMYGDDKEYLMIQVVVLQCIIWYTLLLFLFEYRETRTSVFSKFKESSFSLPEREKENFKGTAEKVGGNCSSEDEVINVIATTPSSQQTAQNVNKIAPDQSQRFKPMVAASVEGERNELHLFIWRCGCCISPATCESVQAGQREESSGKAVASEKQADVENSSIPSSLSSAMLLKILRKVWFKLVRNPNSYSSLLGLSWALVSCRWDIKKPQIMENSVTILSSAGLGMAMFSLGLFMALQPRIIACGTKLALYGMLARFITGPALMAIASVVVGLRGTALKVSIVQAALPQGIVPFVFSREYNLHPDVLSTAVIFGMIVSLPITILYYILLGI
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane; Mediates both low-affinity uptake and efflux of sugar across the plasma membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAGLSLQHPWAFAFGLLGNVISFLTFLAPIPTFYRIYKSKSTEGFQSVPYVVALFSAMLWIFYALIKSNETFLITINAAGCVIETIYIVMYFVYAPKKAKLFTAKIMLLLNVGVFGVILLVTLLLFKGDKRVVMLGWICVGFSVSVFVAPLSIMRRVIQTKSVEYMPFSLSLSLTLSAVVWFLYGLLIKDKYVALPNILGFTFGVVQMVLYVLYMNKTPVAVAEGKDAGVKLPSAADEHVLVNITKLSPALPDRSSGVHRATQMAAVPASSCAAEAAAPAMLPNRDVVDVFVSRQSPAVHVV
The following text describes a protein:
Function:
Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Acts by mediating symmetric dimethylation of 'Arg-118' of NDUFS2 after it assembles into the complex I, stabilizing the early intermediate complex.
Subcellular Localization:
Mitochondrion.
Sequence:
MFRSPAAAAASALLRRLGPRVSGGGGGASTHRRFAPPVSTSILSRYSSAPTSSPSPPPPPPPPPSDAAADGDNRAESGEPGSSLSITIDRSGLYNPPEHSHEPSSDSELVKHLKSIIKFRSGPISVAEYMEEVLTNPQSGFYINRDVFGTSGDFITSPEVSQMFGEMTGVWAMCLWEQMGQPEKVNLIELGPGRGTLLADLLRGSSKFVNFTKALNINLVECSPTLQKVQYNTLKCEDEPIGDKTRTVSKLCGAPVHWHASLEQVPSGLPTIIIAHEFYDALPIHQFQKASRGWCEKMVDLAEDSSFRFVLSPQPTASLLFLSKRCGWASSEELEKVEHIEVCPKAMEITEQIADRISSDGGGALIIDYGKDGIVSDSLQAIRKHKFVHILDNPGSADLSAYVDFASIRHSAKEASDDISVHGPMTQSQFLGSLGINFRVEALLQNCATDEQAESLRTGYWRLVGDGEAPFWEGPDDQTPIGMGTRYLAMAIVNKKQGTPVPFE
The following text describes a protein:
Function:
Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine results in repulsion of the peptides. Consequently, MprF is shown to affect resistance and susceptibility to moenomycin and vancomycin, resistance to human defensins (HNP1-3) and evasion of oxygen-independent neutrophil killing and susceptibility to methicillin, oxacillin, bacitracin, gentamicin, beta-lactams and synthetic peptides (hBD3, CAP18) and other cationic antimicrobial peptides.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNQEVKNKIFSILKITFATALFIFVAITLYRELSGINFKDTLVEFSKINRMSLVLLFIGGGASLVILSMYDVILSRALKMDISLGKVLRVSYIINALNAIVGFGGFIGAGVRAMVYKNYTHDKKKLVHFISLILISMLTGLSLLSLLIVFHVFDASLILDKITWVRWVLYVVSFFLPLFIIYSMVRPPDKNNRFVGLYCTLVSCVEWLAAAVVLYFCGVIVDAHVSFMSFIAIFIIAALSGLVSFIPGGFGAFDLVVLLGFKTLGVPEEKVLLMLLLYRFAYYFVPVIIALILSSFEFGTSAKKYIEGSKYFIPAKDVTSFLMSYQKDIIAKIPSLSLAILVFFTSMIFFVNNLTIVYDALYDGNHLTYYILLAIHTSACLLLLLNVVGIYKQSRRAIIFAMISILLITVATFFTYASYILITWLAIIFVLLIVAFRRARRLKRPVRMRNIVAMLLFSLFILYVNHIFIAGTLYALDIYTIEMHTSVLRYYFWLTILIIAIIIGMIAWLFDYQFSKVRISSKIEDCEEIINQYGGNYLSHLIYSGDKQFFTNENKTAFLMYRYKASSLVVLGDPLGDENAFDELLEAFYNYAEYLGYDVIFYQVTDQHMPLYHNFGNQFFKLGEEAIIDLTQFSTSGKKRRGFRATLNKFDELNISFEIIEPPFSTEFINELQHVSDLWLDNRQEMHFSVGEFNEEYLSKAPIGVMRNEENEVIAFCSLMPTYFNDAISVDLIRWLPELDLPLMDGLYLHMLLWSKEQGYTKFNMGMATLSNVGQLHYSYLRERLAGRVFEHFNGLYRFQGLRRYKSKYNPNWEPRFLVYRKDNSLWESLSKVMRVIRHK
The following text describes a protein:
Function:
Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development.
Sequence:
MKSVKKATSTAHSKASNSSRSKKLRRKMEDGRQEEEEEQEEEAAEEEMEEEADEDSGQPLAHVDPKNMLLKMEPTEQEVTESQVTDQEKAAQSADQMTGMEEEKGLPHTVKSEPNIEASSDGQTVNKISYDLARWEMPSSRKTATFKSKAPKKKYIEGHGSQEGQEDSSSSSEGPATLHDCSGEQPVSSVIVSEERCHSVRSSSTDTASEHSAELEEETEKTHIDIAPSFGPGTDPGFHHLRPQRILVRREDSFQLCQVKQFRQNQVGVQFPGEQSLTFVDITQHLVLLDKIPQPGEVEVGMPVCFCMCPDDTVFREGIVVEIAQNPLSYKVCIQPSPGRREREYRLVPHSCIRLLCSPWCKESVLATPQIAEEKKQQATGRFATALPLDQPSGSSIELPVSPRGTEQKHLEDAEVSKISFSMPVSEEKLSSIQQRILSPPKSPAFGIMLGHLPEQPSPLLSPDAGSRSSCSSVSLDKCSTPGSRSRTPLTAAQQKYKKGDVVCTPNGIRKKFNGKQWRRLCSRDSCMKESQRRGYCSRHLSMRTKEMEGMSEGRVGREGSAEFEWDDTSRDSEVSSIRTDSRPRLVAPTDLSRFDFDECEAANMLVSLGSSRSGTPSFSPVSTQSPFSPTPSPSPSPLFGFRPANFSPINASPVIQRARSRHVSASTPKGGTVLTPEMLHHAHHRERQAVGILPSFQTNLTFTVPMSPSKRKPDSHHGSVSSAADFQKSDSMDSGVDSVSHTPNPSTPAGFRSVSPAPIFSRSQQASPSQLVSPPAGLTSDPSPSVRRVPAVQRDSPVIVRNPDVPLPSKFVEKLSDGTSRNIGGAASGSSSPRRISKVCSKDHPSKTQLQIPVPINATQMQSAARTLPTGQQSSGEPVTCTSAASTEHPPTVFSISSPFQPVAFHPSPAALLPVIVPTDYSSHPVPKKEIIMGRPGTVWTNVEPRSVAVFPWHSLVPFLAPSQPDSSVQPSEAQQPVNHPGASNQSKEPPESASVAHETVPVASFEDERCTVPHTDIVAPPPTEEPAKQSQHQESLTQGTTGDHRGDSETESDHDDAFFPIGPPDLQLPMLGGKRRTQSLSALPKERDSSSEKDGRSPNKQREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKKSSSDVKQVMPGPWGVHKEMRERSMSETGTMIAAGAAAEVPPSGLLLGSESKLGASTSALATGLPTSSSSSTQISRPRAFSHSAVQSIEHRDDSQALQELKQMCSNRPPYPVQKTAFGGPDSTSFSVPAHSESPTCPASRACSSLPGSYHPQRTASEDMTSDEERMVICEEDGDDDVIADDGFGCPDIDLKCKERVTDSDSDGRSGDEVEDKVQPQRVFSPVIRTSSVSGTFPVSNEGLKSERQQNMAESPKSSDHPQTSYPHGYPPLPPAKPPPRPSTQHQTKRNPEVRFTLVDPIASYERKHSTTVQYSTQSVISSGPPQPLVLPSLPFNHPSSSMYSSAPMSYEGHRGMPDSRPPLPTLGTVLVSGPQGILPSGLKPASTVVTNVVKPVSSTPVPIASKPLPVSRSSSDLSESRIPGSHVGIGVLYAHDRKPMQQLPSPANSPHSQSKPAGGIVTNLVVGASSYGQPAPTTGNGTAHAPVTALQFITQNPAGNSNGAVPLRILQPQELLPAAASKRGSITQVQYILPTIPQQLPGGTAASIHFTLPSANAKMIATPQALPIVQPGPPASPSLGIVSAAGKAQSVSPAPLSGSSTQLLSGPGILSPNAQVQGKMLVPMGTPHVTVRTGSAAPIPLVTPPFPMQNGAQPTNKIIQITPMPMVQSPAPAQSALVPPGNSPLQNAIPVTMATAAVMAATSQPQKVVLPSSTRITYVSSAGVPTVPLVTSSSHSHTAPSGSAPCVQSMALGFTAIGPNGQTIVQPLITGQSQLLAQGQLAVSPASTPPVPQTCSGQVLTAIYPSVGSNALTVPAPPAAQSVVYTVSSTSPISTIPATILPKAITSPQTINSPPAPCIAGSSSTPATAASVTFSLVTSKSPRNLPKPPQKVKATIASIPVGSYEATSPSPCVRNTARPSPLPPCEETPEPRYIAESRGSSMGREPSTESYSVSPFPPAHVREPAQAKQRLSTAEDRASREIWAKNMTDDRSSAPPLPDDKREPPHSPSIKKEPGCSSDFKVTETRLDSNPPTGLPTPSSPVPLPPAQSGEAAKAGTSLSEASERKDGPVKKVKVRPPPLKKTFDSVDNRVLSEVDFEERFAELPEFKPEEVLPSPTLQSLATSPRAILGSYRRKRKNSTVWSPNLDLDSSTEDPVSPKRKMRRRSSCSSEPNTPKSAKCEGDIFTFERTGSEAEDLLGEMEYDKAPYSSLRRTLDQRRALVMQLFQEHGFFPSSQSTAAFQSRYSDIFPTKVCLQLKIREVRQKIMQTATPTECLFAEHPSPSTSEAGPSDMQPPQDPALRSSEPAETSWEEGQEPPETSRSR
The following text describes a protein:
Function:
Binds specifically to the 3'-terminal U-tract of U6 snRNA.
Subcellular Localization:
Nucleus.
Sequence:
MLPLYLLTNAKGQKLFIELKNGETIEGELVNVDNWMNLTLQSVVHAGSDQTLQLPEIYVRGSFIKYIRLQDDIIEKVKQQLNSGKDGSGSNGQQRDRDGRRYNGRREGNAGGRFGNQEHQRKRGGGFQRRDGQYGGSRRGRSGQSGGAGFVQYQQSQQWQSSASQVQS
The following text describes a protein:
Function:
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Subcellular Localization:
Cytoplasm.
Sequence:
MFLSLVGDALQFPHVLFRMFFAQRMLFPLACPPPKSVIKFCVFLTVHRFFSTPSTLITKVCSAVRIISGGEGGAENGDYFRKSLNIMTDASKTTKSVENANIPTLTFVTGNAGKLREVQACLGGYVTTESVKLDLPEIQASSVSRVSREKALLAYERLKKPVLVEDTGLSFEALGGMPGPYVRWFLDAVGPIGLAKMLNGFESRSAQVDCVFTYCASPGEVLQFIGSSRGSISMVPRGEGGFGFDTIFMPDDGNGQTFAEMSASTKNTISHRARALVEVRKHFENSK
The following text describes a protein:
Function:
Polynucleotide 5'-kinase required for both rRNA processing and heterochromatic gene silencing.
Subcellular Localization:
Nucleus, nucleolus. Nucleus. Chromosome. Note=Nuclear dots.
Sequence:
MVKRQRIESSNVPLSAFAVRQLTLSKAARKKDNSSGKKRSVSEEESQDKYEDEMKTEGEFPSYKHTLVQVVVPGVDHRTKLHSESSKNDSEITPDINRSKVNPQEYSEFSVASPQTISPSLPLNLDDETVSENVPHSPQSSNDAIPVIKITEENSFRVKDTLYVGLHKDQKLAMVGTFIFRSVRGKFQLFGATYSSACMSWFPLNAPLAFATPVFSAIDNALPAMQISEYEEDSLNLRSFAVPSYSPKEHEYELEPKDILPNFETVIAFRENENGLSKIARVLPFAKRLFSFKNLLQDASSISNNFEITPESWCSFSNQLLFSTSKSDYVVPRLMVCGPKGSGKSSFSRYITNRLLQQYRHIAYLDLDPGQPEVVPSGHISLYYINSPLQGPVFARMLFPTYMLRLHLGDISPQKDPDHYIACVTRLFAEYKDYIFNQEISQKEIIPLIINCPGWIRGGGAELLSSIVDICQPTEVVYMSREDMKSSHREKKSIYQHKEYMPDFLSSRDEFQLTLLESTWQYLPDPNVNKVTSADNRMLGLLSYLYFNCNLQRWDFTTSLTACQPIATAFKGSSKGIDAVNIIGEPLNVNDVAKTINGTLMALYACDTASLDNSNTQRIVSSPEGIPLIINDGLPLDPNTSHCLGLIVLRTIDLKRNEFHFVGPLNLELIKDAYAKSLKIVLERGRLELPVYAMLDHRLAQYSELPYLDRNHDRVAVGAHRRRVRRNIIRRSTFVG
The following text describes a protein:
Function:
Tubulin-folding protein; involved in the second step of the tubulin folding pathway.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MTNSHSPCQIGDRIESGGYIGTVKYVGPIEGKPSIWLGIDWDNPQRGKHDGRVNGVQYFTTRNPTSGSFIRPEKVNCGKSALASIESRYGQIEDEFTAKINKQKQLLIQQNMNAPFLEMVGFDKVFHKQSDFTALRIVNLRDQGINSAGPPLRLGETCPNIEELDISKNLLVSWESVFEICRQLPRLFWLNVSENLLDLPTISESFPNVTTLICGCMDLDWGHICQLGRIFPSVEEFRAPNNKIRGLSTPEGFFTKLKLLDLEGNNIEFWTEVCKLGDLPHLEQLILEDIGLQLIEFEGDSPKVQVFRAMKKLCVVKNLIREWRSVAELNRLESLENLRFSKNPITESEEPDTIHQIIIAKIANLKILNGVEIEATERRGAEYDYMKKYGLEWLEAKGTNKEADFLKTHNRYLELIQKYGELEESELVSKPKIIKNTLVQLSIIFEDFTIEKKVPLTMTVQKLIVLTQKLFSLSGRPHLIYASKSDPEIEILLEDEMKEIGVYSMQNGDKIIVKDKV
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MADLERLNISCNLTRTPAPLRPSCDPPPTLLAALVVLVFWLWGNLHLPPLPDGAPDPDHQIPAIPEDADEAEVEAAAIPPDGAGTPPRSEREPYGDGGGVSGSGRQEAAPAAAAHFRRDPSSIRYQETEGAAALPSAGTPPRGEREPYGAGGGASCSDRQEAAPAAAAHFRRNPSITYHEVAGADSVDMIRGGSCECDAGACVEVERRAFVHATFDRSGEAAGILQKMVDGFGTILLSADDVEESTIHLANRHLVEALESAHAIGCTADFLSQMLDGWACKLEGDARRIWQGEKCRVYIFLFSNAYDVLLIMRGRGAAFSNEELESMLSAMFRRYKASYLDECWAPLMNHLDRLDKFSAEFCIICRRQMTCKVNANLRYKLRKEIVGLIVPPYQVSFLAQRKNQSRLSRVLHCRKRVMAGKQKMRTAEELEMVINDLFEG
The following text describes a protein:
Function:
Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus envelope.
Sequence:
MSQSLKSQNTNMSDSGCRDPVGDSQNVLENDPSINSQTQDTRVTPNNTAEAQPLQPTSDLKEDHHEIGARAQEHTDTGDRSESPEEPALEKPPLDKAELESSPSSQDTELGHHPHSEHGGGDALDLDPNCSQSDLGGRADAHLESSSVASPEGAGDRGEADEHLESSSAAPTEGAGDRGEAGQELLAEDSTDGQSLGHSNTGPGNQDSLRRRLPVPEAGSHEEETELVKEKQEVAQDTLRKTDKKSLWTYGSVFLGCLIVAVVLSSVNSYYSSPAQQVPQNPALEAFLAQFGQLKEKFPGQSSFLWQRGRKFLQKHLNASNPSEPATIIFTAAREGKETLKCLSYHVANAYTSSQKVTAVSIDGAERALQDSDTVKLLVDLELSDGFENGHKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEEETLEASVSPREIEEKVRDLLWAKFTNSESPTSYSHMDSDKLSGLWSRISHLVLPVQPVRNIEERGCLL
The following text describes a protein:
Function:
Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.
Sequence:
MVHQGIVQPLLTDLYQITMAYAYWKFNKQSQAAVFELFFRNNPFKGGYTIFAGLSDCIEFVSNFAYSKSDIDYVKSILPSSVEEEFFHFLSGIHGDQVTIAAVPEGSVVFPRVPLLRVEGPLATVLLMETTLLTLVNYASLVTTNATRFRLTAGNDKPLFEFGLRRAQGPNGGLSASRYCYIGGFNGTSNVLAGKLFSIPVVGTHSHAFVMSFSGLTDLCKTHVQYATGSDSKLFDLKCGTQKWLTQISPMLDVAEDEIIEGELAAFISIAIAFPTNFLALVDTYDVIRSGIPCFCAVTLALDEAGYRAKGIRLDSGDLAYLSRQSRCQFQLLAERLNKPWLSLLTIVASNDINVRTMNSLNQQGHQINAYGIGTHLVTCQEQPALGCVYKLVELDGVAKMKLTQERSKLSLPAKKKVYRLFGENGSPLADLLQKYDESPPLVDQQVLCCHPFQESERKYIVPSRVEEMNCNYWIKGKSCKEIPKLVDIRNYCQNQVNSLRRDHQLLSNLNTYKVFVSDALYQTMHKLWVGDTTMREPGSYHE
The following text describes a protein:
Function:
Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of a dividing cell. Overexpression leads to the suppression of the formation of cellular projections containing F-actin and to a defect in cytokinesis.
Miscellaneous:
MISCELLANEOUS: rgaA lacks rasGAP activity in vitro. rgaA expression is inversely correlated with the speed of cell motility.
Subcellular Localization:
Cytoplasm, cell cortex. Cleavage furrow. Note=Enriched in the cortex of interphase cells and translocated to the cleavage furrow during cytokinesis.
Sequence:
MNKEEYSDISDSESEEVHETNNHNEHEHEEEDDTPEIVVPERKFLKEDEDYSVPFPVMRECLVLLLQSRRILRDMMYYRFKMDRFLSGNLSVFEIQNLLHSQREDKESDWIAEIQELKRNLVSEVRRNHTLERDLNRLDKRIALLIKNRGNIQDVLADKAGLKAPKHKGDQKKPELINDPKKLEAYQNLFYLLQTEPKYLAGLVYLIQPEQMESFLGTVILTLFGDAFTPREEFLLLSLYRLSIQKEMANIATVGDFLKADTVVPKMIITYNKRKQGTDYLKAVIGPILSNVIKQELNLELKPNLVYAAIISEQEIRTGEKSTLDRNVSHEKALEVPEVTKTIKARVDQLISICEQFLDGIISSLNRLPYGIRWICKQIYQIAEKNFTKSTQDEILKVIGYFIYYRFIQVAMVSPEEYDLVGREIHPTARKNLINVSKVLQALFNFAQFGSSEKHFIPLNGWITSHMGDIKNYLQEIIEVGEPEDYLQVDKYMELTQKTKPVIIISLPEICNTHQLISKNLDSLVAKGEKDDPMRIIMKELDEFGPPPDIAADDDREVQLTLSNKFQKTIEEELSPGESLLSQTKEMVISLLRALPTLPEQKDQSDEPPNLVDVLNKARQADPSLEPEIKKILDNLKKLEEYNLTTSADNYSSFLKAVALEVVNRAEIREQQKKEKQRLTTSLNNLRKHQKYLNEQIAQYNQYLQDCRLKHYQNKSKKKKKGDGAKVGPFKFSFSELHKKGVIVDSEVPQITRKKIKFVISSDTVGVFDVSAKMAGIDVQTMRLELDDLLELNSIGTTTLELDQITLDVNMTIHLLNKLFLY
The following text describes a protein:
Function:
Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cell-mediated inflammation by activating ITCH and thus controlling JUNB degradation. Promotes pancreatic beta cell death through degradation of JUNB and inhibition of the unfolded protein response, leading to reduction of insulin secretion. Restricts the production of pro-inflammatory cytokines in effector Th17 T-cells by promoting ITCH-mediated ubiquitination degradation of RORC. Together with NDFIP2, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination. Regulates peripheral T-cell tolerance to self and foreign antigens, forcing the exit of naive CD4+ T-cells from the cell cycle before they become effector T-cells. Negatively regulates RLR-mediated antiviral response by promoting SMURF1-mediated ubiquitination and subsequent degradation of MAVS. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus where it mediates KCNH2 degradation. In cortical neurons, mediates the ubiquitination of the divalent metal transporter SLC11A2/DMT1 by NEDD4L, leading to its down-regulation and protection of the cells from cobalt and iron toxicity. Important for normal development of dendrites and dendritic spines in cortex. Enhances the ubiquitination of BRAT1 mediated by: NEDD4, NEDD4L and ITCH and is required for the nuclear localization of ubiquitinated BRAT1. Enhances the ITCH-mediated ubiquitination of MAP3K7 by recruiting E2 ubiquitin-conjugating enzyme UBE2L3 to ITCH. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate. Inhibits cell proliferation by promoting PTEN nuclear localization and changing its signaling specificity.
Subcellular Localization:
Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane. Synapse, synaptosome. Cell projection, dendrite. Secreted. Note=Detected in exosomes and secreted via the exosomal pathway.
Domain:
The PPxY motifs are required for E3 ubiquitin-protein ligase binding and activation and for ubiquitination.
Sequence:
MALALAALAAVEPACGTGYQQLQNEEEPGEREQTAGDAPPPYSSISAESAAYFDYKDESGFPKPPSYNVATTLPSYDEAERTKAEATIPLVPGRDEDFVGRDDFDDADQLRIGNDGIFMLTFFMAFLFNWIGFFLSFCLTTSAAGRYGAISGFGLSLIKWILIVRFSTYFPGYFDGQYWLWWVFLVLGFLLFLRGFINYAKVRKMPETFSNLPRTRVLFIY
The following text describes a protein:
Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins. Cleaves precursors of SUM1 and SUM2, but not of SUM3 or SUM5. Able to release SUM1 and SUM2 from conjugates, but unable to cleave SUM3. Protease activity mainly directed at deconjugating SUM1 and SUM2 from their target proteins. Regulates salt stress responses and flowering time. Redundant with ULP1C.
Subcellular Localization:
Nucleus speckle.
Domain:
The N-terminal regulatory domain is not required for peptidase activity in vitro.
Sequence:
MTKRKKEVIDVDCSEKKDFVIDWSSAMDKEDEVPELEIVNTTKPTPPPPPTFFSDDQTDSPKLLTDRDLDEQLERKKAILTLGPGLPDKGEKIRLKIADLEEEKQRRVLEGSKMEVDRSSKVVSSTSSGSDVLPQGNAVSKDTSRGNADSKDTSRQGNADSKEVSRSTFSAVFSKPKTDSQSKKAFGKELEDLGCERRKHKAGRKPVTRLSNGWRLLPDVGKAEHSAKQFDSGLKESKGNKKSKEPYGKKRPMESSTYSLIDDDDDDDDDDDNDTSGHETPREWSWEKSPSQSSRRRKKSEDTVINVDEEEAQPSTVAEQAAELPEGLQEDICYPTRDDPHFVQVCLKDLECLAPREYLTSPVMNFYMRFLQQQISSSNQISADCHFFNTYFYKKLSDAVTYKGNDKDAFFVRFRRWWKGIDLFRKAYIFIPIHEDLHWSLVIVCIPDKKDESGLTILHLDSLGLHSRKSIVENVKRFLKDEWNYLNQDDYSLDLPISEKVWKNLPRRISEAVVQVPQQKNDFDCGPFVLFFIKRFIEEAPQRLKRKDLGMFDKKWFRPDEASALRIKIRNTLIELFRVSDQTE
The following text describes a protein:
Function:
Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate, and MTMR6 binding affinity for phosphorylated phosphatidylinositols (By similarity). Positively regulates lipid phosphatase MTMR7 catalytic activity. The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels (By similarity). Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles (By similarity). Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6 (By similarity). Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine (By similarity).
Subcellular Localization:
Cytoplasm. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Localizes to ruffles during EGF-induced macropinocytosis. Colocalizes with MTMR6 to the perinuclear region (By similarity). Partially localizes to the endoplasmic reticulum (By similarity).
Domain:
The GRAM domain is required for cell membrane localization; The coiled coil domain mediates interaction with MTMR9.
Sequence:
MEFAELIKTPRVDNVVLHRPFYTAVEGTLCLTGHHLILSSRQDNTEELWLLHSNIDAIDKRFVGSLGTIIIKCKDFRIIQLDIPGMEECLNIASSIEALSTLDSVTLMYPFFYRPMFEVIEDGWHSFLPEQEFEFYSSATSEWRLSYINKDFSICPSYPPTVIVPKSVDDEALRKVAAFRHGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRAGKRGYLIDTRSLNVAQQARAKGGGFEQEAHYPQWRRIHKSIERYHVLQESLIKLVEACNEQTHNMDRWLGKLEASNWLTHIKEILTTACLAAQCIDREGASVLIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIEREWLQAGHPFQQRCAQSAYCSSKQKWEAPVFLLFLDCVWQILRQFPCSFEFNEHFLIMLFEHAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNRPGELSKFTNPLFEANNLVIWPSVAPQSLQLWEGIFLRWSRSSKYLDEAYEEMVNIIEYNKELQAKVNVLRRQLAELETEDGL
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRFLGESPNGIYLYHDGRVKLLEGRRVVDCDDVSSVSQSEAGDEDRFSFTSSMVQSLDGNSSDLENSSEENCVSMSNLKKLKFLLKLGQLLGLAPVKFYVQKFYVVILAFLLTAGAIISLVYQAPVYKELTDIKLVLNILSDVTLWLSNVNSLTLTLKRKKWNLLFKTLTHDEPRKSSLVQLILTQAIFLMFVSYNIYVCQTVSNFEYFQRKILLMIQLYYLYFDVIVISTFLQLFLEHYEVINRQTLDTADVKTLTTVVEKECYKMKVTIDAFNDIFGWSFLLFTLYSSLLLLDYVSCVVALIILILQCGRVRSEVVKILNVLKKIALRRQTTNGDLDELIVTLSAHYFPVFSACDYFTIETKTVLDVLGVTVTYLIVIIQFDDKIVQV
The following text describes a protein:
Function:
May function as negative regulator of flowering transition.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing VQ29 have delayed flowering.
Subcellular Localization:
Nucleus.
Sequence:
MEATSQQFMSQSYLNAQETTTRATKNYLTSLHSTRKQPSKPLKRPAISSPLNPMHPHVYRVEPVNFKVLVQRLTGAPEHETVQAKPLKTSDDAAKQSSSSFAFDPSSSWGDFSFQNPANISRW
The following text describes a protein:
Function:
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MIYTLCDMAQLSGVWSACPFLKQVPPATKLLTITTVSVFILSRLGFLSPYFPYNQWSTLFQTWELWRPFTALIAIQGSAIPAFYTAYQMYSYSNDLEANHYGGITAKYAWWLTFISLFIWIGDYLLINSPFYTRAFMMALTYAWVQDHKYNQVSFYFVSFSAKFLLPVNLFISLLDDPSDLYPCILGIVAAHTFYFLDTIYPSVYPTYGKFRIVEPPQFYYTLLGTESSAYTSNMGTGSQAPTNPAGASNAWGLGGGPVGGAAADGATTTGASVRSEGSGSFSGRGQRLGT
The following text describes a protein:
Function:
Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
Sequence:
MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNGRPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALYGYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAYPRRSNLA