lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.
Sequence:
MTDTTTAAKKRFIGKSGGAATKNNSTRTAAKKRTNEVPREILENELLNRLIQECLPKTYNFELHKTIHQVIQNQVTILGLQMPEGLLQFSLTISDLIRKFCPDCQHVVVLGDVTYGACCVDDFTAKALGCQMLIHYGHSCLIPVDQTSIKTLYVFVEIGIDRSHLTDTIRANFPQCLREEEAEAEVAEGGLKHLSIEHEDSNPGEQELHLAIVGTVQFVSAVQALKHELELPTSTLPLAQQPKQITHQTIPDDALQPAPKASSCRFRVTVPQVKPLSPGEILGCTAPRLASDVDAILYLGDGRFHLEAIMIANPSIPAFRYDPYEKKITREGYDHVQMRRVRASAIHLARHSLRTGPVSSPNNTPKEDLSSSCLDQEEGASDRAWAVVLGTLGRQGSLSVLKSITSGLGAKSGPKKLAVPLLVSELSALKLGPLTAHIDVCVQTSCPRLSIDWGHDFLCHRPPASQAGAADGHRTARVVPLLNPYEAKVALGQAVGFHLESLNDSADRSLLDSYPMDFYADESLGDWTPRHGRNIRPRRAPVVPPVQ
The following text describes a protein:
Function:
May regulate sister chromatid cohesion during mitosis and couple it to DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MATRATRAASEVAKTKAATNLPSIRKRKSIENEEEESKHNTSINDDGELDSDIDEEDESKFEKEFTVKKRQKKSPAKTQQQPQKSITTPTKPTPTKTTSKPTKPSATTSPSQQKQSSQSSQNTSKKQATSSSSQQSTQQKKKETKIKYNLKPINIERLATYDQHMSGTLSNEKIIKRLKKLDEYLQDKKRGNTEGLEIVLEVLIDPKFADNKIFEIRLMTSCCLSEIFRIYAPTLPFDMVVLKVVFKLFTEQVLQGDKVDKKLFPQYFQMLERLSVIKVFALLALVDSSMLTPFFKDCLSRVHGDKEHQPMDIMFSTLLNTILESLEEVPTSLWNELLESLIEREKGGVPTSKAIFTHDLIETNSRFLQVHFDLFLQDLLEPEILAGGQQQQQQDSSLSNNGISKQLKKKKNEILFEMFNILPEFIYPALQNLEFDLEDVNASIRKGAAIVLSRCYSTESASDELIAQRPTLYTTFLNRFHDVDIKIRTVMMEFSEHFTTTSDLEMERVLKSVRDRFRDSEPDIRIKAIQIFQKYIIKNPELMNPELMSEYLERVRDKDSKVRKDAEISLSTVWRSVREKYGPIDDWSNTLIDCFSTIPNTLIHCLGLYDDDKYRIEIAFDSILLPQHSDVKNRSQVFLEIYKYLDESNKQLFKKYLEEKKSLRQEFLALIQFLKNPKVVGGSTTPTSKKSQPPQQQQQQQQQQQQQLQQPENDIEVYITHVDNLLPKFIGESSKKLVRQLITPSNKKILDLLVLISDINTTFQEQYNIKISIISKAQNESSFSEFIKYMVNKLAYSIVGKENIKYLLRGLRSDLGLDNFDKNNPIDLLEEFNEKIYEKEVKDGVPETLEVLLMLSQVYANIFDDYGDQLVGFLTCSKSIVYPVLQILSNSWKTLKLSKKTLKSTLDMLLRLTQVPQPTLARLAFKTFIKFATPALTSINSTNGKVDNNKLVVTLKDLANNLFDQLEDKSKNLLSILEVIGCLAKGYSLVLSEHLDTLDILLIKKIMTGVCTLDFNQKVQLNKSVEHHLNTSYSKDVLIKIAAIKCMSNYLLGLREITKKSHEMVNMLFEFYIGLDKNKTYNDLEKSHLKIHIAIGLLRVFQRSQYEKEITPQQFILICNSTSITTKQRGDPLIRRLIEKLAKVMILNRLPMKYMAAFGMAAQQPYSVLALVRKHSTSIIKTRRMVISRLAASLSMAKNLTEFYPESSMPYFLYVVSHREDFERDAPDYIESACYLNFFIDLLVEEADNYSIIHTIFTKLKRSTDALDKKSKNHIIAAELGLQILTHQYQQKKWKPQKHPIVIVLPEKFYIIHDDQDEMSIDDEVTSIKLPSLLPKRFKLPPLPSITDQNNNNNNNNTNSTNNDESEKDENNNNKNDNDNDNDNDDNSTTAVPQKSIISKPPAKKVSKKAAAKQKSPKKKTNKKKKQSSSEEEVSSSEEEDESQDEEVEN
The following text describes a protein:
Function:
May be involved in the establishment of the daughter fate.
Miscellaneous:
MISCELLANEOUS: Present with 922 molecules/cell in log phase SD medium.
Subcellular Localization:
Bud neck.
Sequence:
MPRKFLGNKIEKNVDAVRPSSLTLTADDLKYIPPIPQDFEDEDDKVLRTSNGGNRLSKRFGGTLKLKKRLESVPELFLHDFKKRPRSQLEVIREKKFTDMQVPKGPVCPQSTILPLRERKKVKSLPIQRKSLRRPTLSKPAVVQSLGHKTHSDHIIDKVFVSRPAPIVMPVKALTPINPVSLMQTQTQDCCRKNKYGKSGSEILFDEILSAYENVSTSDSTALNSEIDRIIDICASKQIAKKNEAFQVPYVVCPDDTETLFSSTTPKLKPVNSNTLNDVISSPEYTTSGCSTYSDQSNSDEELSEVESIVWNTNKRTMRSSIVSESTSEEGYCTAAETLPSTVSVEDLDIHNKLPKVAQTSSCNTLLNKLSIRKLKKVILDPPKIMHVMTFDDDSDDGDDNDDEDRALNILQKKIDCIEIASCSSSIYSE
The following text describes a protein:
Function:
Functions as a negative feedback regulator of mTOR function.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MYYAVDYYADMGQISQDCFAATQTGASDFDMDELDDLDQVTQVIGYHPQFHDHFLATQNFIMKGDGPLPNDYRYYLAIIAAARHQCPYLVKRYEKEFINQGGDSAWLGGLDFIPAKLRAIYDINKILAHRPWLLRKEHIERLTKGKNSWSLSEVVHAMVLLSHFHSLSSFVFSCGLTQKLDGLSSPKLKSPPAAVAALAPTILITPTSPTEPQKGKPVLAEISLNNANPDYDSQTAASSNGGAPPDSANAVADGPDATTLNGYLATAQQLPQQHGISVETLMERMKVLSQKQDECSEAELSSRFQKVEQQTAELAAVTPEAAVGVPTNLSHYVDDANFIYQDFARRGTESINTFRIQDYSWEDHGYSLVDGLYNDVGIFLDAKFRAAYNLTYCTMGGIKNVDTSKFRRAIWNYIQCIYGIRHDDYDYGEVNQLLVRPLKMFIKTACCFPERITTKDYDSVLVELQDSEKVHVNLMIMEARNQAELLYALREIMRYMT
The following text describes a protein:
Function:
Contacts the emerging nascent chain on the ribosome.
Sequence:
MFPGKVNPRMLKKMQKMMKDFGMETEDLDVRKVIFVFDDEEWVFEEPKVQVMDILGVKTYSITGKPKKIKKEKVEEEEEVKVEITEEDVELVAKQCNVSKEEARKALEECNGDIAEAILKLEEEKEEN
The following text describes a protein:
Function:
Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate (P5C) to L-proline using NAD(P)H. Proline is synthesized from either glutamate or ornithine; both are converted to P5C, and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCR3 is exclusively linked to the biosynthesis of proline from ornithine.
Subcellular Localization:
Cytoplasm.
Sequence:
MDQLRVGFIGAGKMANAVAQAILLAGRTRSTLPSSSEAKSPKDNFGRYHGFSHRKLLRSQAEQLGAHHPGGQLRLFRSQNHVESQSQTSQDAASHLRSPGMGSTSYARSTAQYPKTKYWRPDGDVKAVNIFASAPSNRNLEKFQTLSCRTTHSNLEVLQNCSFVFLATKPHILPTVLHEIAPAVTPEHVFISMAAGVTLETLEERLPAGTKVIRIIPNLPCVVQSGAIILSRGSCVGEKEVDLLKKLLSPSGLCEEAPESYIDIHTGLSGSGVAYVYMFAEALAEGAVKMGMPGPLANKIAAQTLLGAAKMMLETGEHPAALRSAVCTPGGTTIHALHELEKGGLRATVMNAVEAATNRAREMGKR
The following text describes a protein:
Function:
Transports the metallophore pseudopaline, which is involved in the acquisition of nickel and zinc, and thus enables bacterial growth inside the host, where metal access is limited. Is probably involved in the export of pseudopaline (By similarity). Essential for iron acquisition during the interaction with airway mucus secretions (AMS).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MVLDLLKSGVLLAVLASFTFSVMNALVKEASATLPAAEIVFFRSAIGTLLIYLLMRQAGVALSRQGVPMLLVRGVMGALYLVCYFYAIAHIPLADASILAHMSPFFVILFSALFLGERIPRAVYWLLLVVVLGALMIVKPFSYSSYSVYAVVGLLSAVFAAGASVAIRQLSARHHTYEIVFYFLAVATLVAIPLMWNDFVVPATLREWGLLLAIGVVSLLGQVFLTRAFSHESATIVAVTRYIGIVFNAGWGWLFWSEVPDALTIAGGVLIVVACIALSRTKKG
The following text describes a protein:
Function:
Probable zinc transporter involved in Golgi membrane trafficking through the regulation of zinc homeostasis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein.
Sequence:
MNVNSSAFERTNRFPSFPVLKDDQKTSSDSIAAAKKKDLLSLISSKSLLSSETLGWFSVICAFSITGSGLEVNTMSIPFYLIFGIFAFVSFTTQYLGIYSFSFQPFQLLNVIIASLSMVFITLGAFVLGTLDTTCLLLLAFKLFFIRNDPTPFNARSANLKNYIAFPICLFVINHILILLGYFQCSYSVFYASVFYILLGVFIRVFYLVNKEKFEKKELAFLFSSIVVACLIQFNVLPLGTINLSVTRFTILCFMQIFCINWDGIARIQFYLGKFDISLIMALISAIINKTASQNSIKIISCLYQVGFCFFKIGSSITANLKLPDNSRIYRLYNDFIVNGVLADKESRSIFYFFLLNVSYMFVQVIYGLWTNSLGLISDAIHMAFDCIAILVGLVATTLAKMPLNYAYPFGFAKIEALSGFTNGIFLVLISFSIVGEALYRLFHPPQMNTDQLLLVSFLGLVVNLVGILAFNHGHNHDHGSHHHHSHSNHSMCLPNTTNDINIFEEFEEEKDNVEAQKMGYTNDDHVSQHEHTHENSQEHHHEHNHNHDHIHKYNEKCDHESISLQNLDNDHHCHHHHENHNMHGIFLHIIADTMGSVGVIVSTILIQWFSWTGFDPLASLIIAALIFVSVLPLIKDSAKNLLSVTDPESEYLLKQCLSNISLSNSVISLSNPKFWTNERGEVYGILHIQVSIDGDLNVVRNEVFRKLSIAVPNLKHICIQSERPNNCWCGK
The following text describes a protein:
Function:
Probable pheromone carrier.
Subcellular Localization:
Secreted.
Sequence:
MKAVFLTLLFGLVCTAQETPAEIDPSKIPGEWRIIYAAADNKDKIVEGGPLRNYYRRIECINDCESLSITFYLKDQGTCLLLTEVAKRQEGYVYVLEFYGTNTLEVIHVSENMLVTYVENYDGERITKMTEGLAKGTSFTPEELEKYQQLNSERGVPNENIENLIKTDNCPP
The following text describes a protein:
Function:
Probably participates in a plant defense mechanism.
Domain:
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Sequence:
GIPCGESCVWIPCISSAIGCSCKNKVCYRN
The following text describes a protein:
Function:
Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
Subcellular Localization:
Cytoplasm.
Domain:
ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site; The C-terminal coiled-coil domain is crucial for aminoacylation activity.
Sequence:
MTENSQQPQPAPSTELPTQYTPAEVEGQLYERWVERGYFEADAKSDKPPYTVVIPPPNVTGSLHLGHAFEHTLIDALTRRKRMQGYETLWQPGMDHAGIATQNVVERELGKEGKSRHDLGREAFVERVWQWKSESGGQISGQMRRLGDAVAWSRERFTMDEGLSQAVQTIFKRLYDDELIYRAERIINWCPRCLTAISDIEVEYQDDDGELVSMKYGEGDETIVVATTRAETMLGDTAVAVHPEDERYKHLVGKLIKLPLTDRSIPVVADEHVDPEFGTGAVKVTPAHDPNDFEIGQRHGLPAIAVMDEHAVITAHGPFQGQDRLEARSAIVAALRAEGRIVAEKRPYVHSVGHCSRCKTTIEPRLSMQWWVKVGPLAKAAGDAVRDGKVKIHPQEMEKRYFDWVDNLHDWCISRQLWWGHRIPVWYGPEGEVVCVGPGEEPPSGEGWYQDSDVLDTWFSSGLWPFSTLGWPEQTESLAKFYPNSVLVTGYDILFFWVARMMMFGLYAMDGTPPFHTIALHGMVRDQNGKKMSKSFGNVVNPLDWMDKYGSDALRFTLARGANPGVDVPIGEDWVQGSRNFANKIWNATRFALMNGATVEGPLPDASRMSSTDRWILSRLNSVVAEVDAYYEDYQFAKLSDALFHFAWDEVFDWYVELSKTTFQAGGEAAEVSKRVLGEVLDVTLRLLHPVVPFVTETLWTTLTGGESVVIAEWPTDSGFRDAGAEREIETVQSVITEVRRFRADQGLQPGQRVPARLTLAGSALAAHEAAVRQLLRLQPEGDAFTATATLPVAGVEVALDLSGVIDFAAERKRLAKDLAAAEKEKAQANAKLGNEAFLAKAPDQVVDKIRGRLAKADEDITRITAQLEKLPEA
The following text describes a protein:
Function:
Necessary for the splicing of pre-mRNA.
Subcellular Localization:
Nucleus.
Sequence:
MPPSTVNQEVNSILFIKNLSFKITAEEMYDLFGRYGPVRQIRLGNTVQTRGTAFVVYENVQDARRACEKLSGYNFMDRYLVVHYYNPERAKVDGQDLAARYAALEQVKQKYGVQL
The following text describes a protein:
Function:
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. rrp4 as peripheral part of the Exo-9 complex is thought to stabilize the hexameric ring of RNase PH-domain subunits (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVTILKPEEFYVSSEADIVNDVSMTEMEDEIMEDEQMGLVDGEDVLEEFDKSIHQNLVTPGQLVTDDPQFMRGHGTYFEDGGIYASVAGSVQRVNKLISVKPLRSKYVPEIGDLIIGKIAEVQPKRWKVDIGAKQNAVLMLSSINLPGGIQRRKLETDELQMRSFFQEGDLLVAEVQQYFSDGSVSIHTRSLKYGKLRNGVFLKVPPALVVRSKSHAYALAGGVDIILSVNGYVWVSKHNENQHSSVSITRLEEEASESIYSNENDEIDGYTRLNISRVSICIKGLASRSLPLTQASITNFYESSLVFSNLQDLTVPKNMDQIAMEAMQ
The following text describes a protein:
Function:
Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ).
Subcellular Localization:
Nucleus.
Sequence:
MVPLKRRKLSDTGKSGTNTSGGTEPSKFPRVVLFLLERKMGASRRAFLSQLARKKGFQVEELLSEKVTHVVCENVSGEDGRAWLRSQGGSRPPPHLLDVSWFTDSMRAGRPVEVLDRHQLQNPNVSLCPQELQAGEPEVEVFSVPSYACQRRTSLENHNAPLTDALSLLAENAELNDEEGRGVAFRRAAALLKTLPSAVMSASQLRGLPCLGEHSLREILETGTSTEVESTKGSERFKALKVLTGIFGVGAKTADRWIREGIHDLHQLRASGQHYADINQPVTRAEADAIEAIVEKAVSSVLRGAQIVLTGGFRRGKPSGHDVDFLITHPEEGREEGLMPKVVSWLEKTTRNSYLESKDGPGRPPSNMDRFERCLSIFKLPGAAETPQRAWRAVRVDLVVSPISQFAFALLGWTGSKLFERELRRWAGHERGMSLSSHALYDNKQVNEGAASEEEIFAHLGLEFVPPSERNA
The following text describes a protein:
Function:
Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.
Sequence:
MSINKLSRGLIQVYTGDGKGKTTAALGQSIRAAGHGLKVLFVQFIKGNSFTGEFLFLKNSQNITFWQFGRDCVYSSGIRENIVECNNCYECFIGKEGPSEMDIKVVRGGWERVKSVIEDYDLIVLDEISLAIFYKIISAEEIIEFLKNKPEKLEIILTGRYMPEAIMDLADLITEMKEVRHPYSKGISARWGIDY
The following text describes a protein:
Function:
A structure-dependent 5'-3' DNA helicase that unwinds a number of substrates that resemble intermediates in DNA repair, recombination and replication. Translocates on ssDNA with 5'-3' polarity; Unwinds G4 DNA (planar arrays of 4 guanine bases stabilized by hydrogen bonds) with both 5'- and 3'- ss-tails.
Sequence:
MSESVSMSVPELLAIAVAALGGTRRRGQQEMAAAVAHAFETGEHLVVQAGTGTGKSLAYLVPAIIRALCDDAPVVVSTATIALQRQLVDRDLPQLVDSLTNALPRRPKFALLKGRRNYLCLNKIHNSVTASDHDDERPQEELFDPVAVTALGRDVQRLTAWASTTVSGDRDDLKPGVGDRSWSQVSVSARECLGVARCPFGSECFSERARGAAGLADVVVTNHALLAIDAVAESAVLPEHRLLVVDEAHELADRVTSVAAAELTSATLGMAARRITRLVDPKVTQRLQAASATFSSAIHDARPGRIDCLDDEMATYLSALRDAASAARSAIDTGSDTTTASVRAEAGAVLTEISDTASRILASFAPAIPDRSDVVWLEHEDNHESARAVLRVAPLSVAELLATQVFARATTVLTSATLTIGGSFDAMATAWGLTADTPWRGLDVGSPFQHAKSGILYVAAHLPPPGRDGSGSAEQLTEIAELITAAGGRTLGLFSSMRAARAATEAMRERLSTPVLCQGDDSTSTLVEKFTADAATSLFGTLSLWQGVDVPGPSLSLVLIDRIPFPRPDDPLLSARQRAVAARGGNGFMTVAASHAALLLAQGSGRLLRRVTDRGVVAVLDSRMATARYGEFLRASLPPFWQTTNATQVRAALRRLARADAKAH
The following text describes a protein:
Function:
Catalyzes the cleavage of beta-carotene at its central double bond (15,15') to yield two molecules of all-trans-retinal. Exhibits the highest activity for beta-carotene, followed by beta-cryptoxanthin, beta-apo-4'-carotenal, alpha-carotene, and gamma-carotene in decreasing order, but has no activity on beta-apo-8'-carotenal, beta-apo-12'-carotenal, lutein, zeaxanthin, or lycopene, suggesting that the presence of one unsubstituted beta-ionone ring in a substrate with a molecular weight greater than C35 seems to be essential for enzyme activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGLMLIDWCALALVVFIGLPHGALDAAISFSMISSAKRIARLAGILLIYLLLATAFFLIWYQLPAFSLLIFLLISIIHFGMADFNASPSKLKWPHIIAHGGVVTVWLPLIQKNEVTKLFSILTNGPTPILWDILLIFFLCWSIGVCLHTYETLRSKHYNIAFELIGLIFLAWYAPPLVTFATYFCFIHSRRHFSFVWKQLQHMSSKKMMIGSAIILSCTSWLIGGGIYFFLNSKMIASEAALQTVFIGLAALTVPHMILIDFIFRPHSSRIKIKN
The following text describes a protein:
Function:
Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched on hermaphrodite X chromosomes and during mitosis. Involved in dosage compensation by repression of X-linked gene expression in hermaphrodites. Plays a role in growth and body fat regulation downstream of the TOR complex 2 pathway.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MKVAAKKLATSRMRKDRAAAASPSSDIENSENPSSLASHSSSSGRMTPSKNTRSRKGVSVKDVSNHKITEFFQVRRSNRKTSKQISDEAKHALRDTVLKGTNERLLEVYKDVVKGRGIRTKVNFEKGDFVVEYRGVMMEYSEAKVIEEQYSNDEEIGSYMYFFEHNNKKWCIDATKESPWKGRLINHSVLRPNLKTKVVEIDGSHHLILVARRQIAQGEELLYDYGDRSAETIAKNPWLVNT
The following text describes a protein:
Function:
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane.
Sequence:
MATSLSSLPSVSKLSGLGSCSTAARALGASNGAAVVARVGTKKVATTVKKAAAKVASKAPRPAASRRPASGPDRPLWYPGVQAPEWLDGSLPGDYGFDPLGLAKPAEYLQIDLDGLDQNKAVNKAGDVIGKVQKKAQLVDTKNAFQPYDEVFGLTRFRETELIHGRWAMLGVLGAVAVEALTGVHWQDAGKVELVDGASYLGLPLPFDLPTLTIIEVLLIGYIEFARNGVTDPEERIYPGGYFDPLNLASSPEKAAQLKVAELKHGRLAMVSALGFAVQAFATGTGPLDNLAQHLDSPTTNTIFDTLSK
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MNISIFLIGFVFFMGGISVWLMPTFKLGIFFLEWDFLSLKFNFYFNSILFSFILFLVTFSVLVFSTYYLNSELNFNYYYFVLLIFVGSMFSLNFSNSIFTMLLSWDLLGISSFFLVLFYNNWDSCSGAMNTALTNRLGDYFMFVFFGLSVFSGYYFLSFSMFSSYMSLLLLLTAFTKSAQFPFSSWLPKAMSAPTPVSSLVHSSTLVTAGLILLMNFNNLVMQKDFISFVLIIGLFTMFFSSLASLVEEDLKKVVALSTLSQMGFSMVTLGLGLSFISFIHLVSHALFKSCLFMQVGYIIHCSFGQQDGRNYSNNGNLPNFIQLQMLVTLFCLCGLIFSSGAVSKDFILELFFSNNYMMFFSLMFFVSVFLTFGYSFRLWKSFFLSFNKVMNHYSSTVFMNFLSLVLVIFSISFLWWMNFNLLNIPSLFLYVDFFGPLVFLFMMIFLSFLILKMLFKELMYKFLVDYLAKNSIYKMKNLKFMDLFLNNINSKGYTLFLSSGMFKNYYLKSLNFNSVVVLIFIFFMIC
The following text describes a protein:
Function:
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTATATTVGEPDRTQPQTTPASRAVSRLARLLPAAAAALSGVLLYISFPPRTLWWLALPAFAVFGWVLRGRGWKAGLGLGYLFGLGFLLPLLVWTGVEVGPGPWLALAAIEALFVAAVGAGVAAVSKLPGSPVWAAAVWIAGEAARARAPFEGFPWGKIAFGQADGVFLPLAAVGGTPVLGFAVVLCGFALHEAVRLAVRARRGDEVRRGAAAVALLGVAVPVVGAVAARPLVSDTAEDGTATVAVIQGNVPRAGLGFNAQRRAVLDYHARETQRLADEVKAGKVARPDFVLWPENSSDIDPFANADARLVIDRAAKAVGAPISVGGVVERDGKLLNEQILWDPDKGPVDTYDKRQIQPFGEYLPLRSLIGAINDEWTSMVSRDFSRGTEPGVFTMAGTKVGLVTCYEAAFDWAVRSEVTDGAQMISVPSNNATFDRSEMTYQQLAMSRIRAVEHSRTVTVPVTSGVSAIIMPDGRITQKTGMFVADSLVQEVPLRSSETPATRLGIAPEIALVLVAAGGLGWAVGAGVRGRRARDV
The following text describes a protein:
Function:
Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site (By similarity). Binds to and inhibits the endogenous nicotinic acetylcholine receptors (nAChR) (By similarity). This neurotoxin is lethal to mice by intraperitoneal or intravenous injection.
Subcellular Localization:
Secreted.
Sequence:
MICYNQQSSEPPTTKTCSEGQCYKKTWSDHRGTIIERGCACPNVKPGVKISCCSSDK
The following text describes a protein:
Function:
Transcription repressor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Regulates, probably indirectly, the activation of defense-related genes during defense response (By similarity). Modulates plant innate immunity against X.oryzae pv. oryzae (Xoo) (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The WRKY domain is required to bind DNA.
Sequence:
MDAAWRGGVGCSPVCLDLCVGLSPVREPSAARHELLDRPAGCRGGGDSKSMTNDEAKILEAKVTQMSEENRRLTEVIARLYGGQIARLGLDGSASPPRPVSPLSGKKRSRESMETANSCDANSNRHQGGDADHAESFAADDGTCRRIKVSRVCRRIDPSDTSLVVKDGYQWRKYGQKVTRDNPSPRAYFRCAFAPSCPVKKKVQRSAEDSSLLVATYEGEHNHPHPSPRAGELPAAVGGAGGSLPCSISINSSGPTITLDLTKNGGAVQVVEAAHPPPPPDLKEVCREVASPEFRTALVEQMASALTSDPKFTGALAAAILQKLPEF
The following text describes a protein:
Function:
Secreted immune-induced peptides induced by Toll signaling. Has a significant role in resistance to infection by the entomopathogenic fungus B.bassiana R444 and weak antifungal activity against M.rileyi PHP1705. In adult males, activity appears to be important for neuromuscular processes that mediate correct wing posture upon Toll activation.
Miscellaneous:
MISCELLANEOUS: In some wild flies and common laboratory strains, the BaraA locus has undergone a duplication event to produce two identical paralogs, BaraA1 and BaraA2. However BaraA copy number varies within these strains indicating that the duplication event is recent and not fixed; MISCELLANEOUS: The name 'Baramicin' derives from the Japanese idiom Bara-Bara, meaning to break apart, and refers to the multiple peptides produced from the precursor protein.
Subcellular Localization:
[Immune-induced peptide 24]: Secreted; [Immune-induced peptide 6]: Secreted; [Immune-induced peptide 12]: Secreted; [Immune-induced peptide 10]: Secreted; [Immune-induced peptide 5]: Secreted; [Immune-induced peptide 8]: Secreted; [Immune-induced peptide 13]: Secreted; [Immune-induced peptide 22]: Secreted.
Sequence:
MKSFGLIALAICGVICVAAEPQHTYDGRNGPHVFGSPGNQVYIRGQNEGTYSVPGVGGQFQNAPQRGEHVYTDEAGNTFVNRKNAGGPASHTISGPNFSAKNLGPNGAKSVGIPQRARRSPQFHVERPGRTVDVGNGGFYIQRGRRSPQLHVARPDRTVTIGNGGVYIQRSRRSPQFHVERPDRTVDFGNGGFSAQRFRRGINDARVQGENFVARDDQAGIWDNNVSVWKRPDGRTVTIDRNGHTIVSGRGRPAQHY
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MRILTNALNKILAGCCCIILAVMVACVSWQVAARFIFNAPSSTLDEFTQILFMWMILLGGVYTAGLKKHLAIDLLAQKLSRTPALMLDSIIQVIITVFALIFMVYGGDIIVEKAAHVSQMSPVLKWPMDKVYWVMPISGVILVYYTIVNVIDNYHQRHLR
The following text describes a protein:
Function:
Guanine exchange factor that acts as an activator of arf1 at the trans-Golgi net-work and is thus involved in vesicular budding and traffic between compartments of the Golgi apparatus (Probable). Activation of Arf (ADP-ribosylation factor) GTPases is essential for vesicle formation via recruitment of cargo adapters and coat proteins necessary for Golgi trafficking (Probable). Involved in tunicamycin-induced ER stress response and subsequent apoptosis.
Subcellular Localization:
Cytoplasm. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, COPI-coated vesicle membrane. Cytoplasmic vesicle, COPII-coated vesicle membrane.
Domain:
The homology upstream of Sec7 (HUS) box is necessary for the allosteric activation of Ssec71; The homology downstream of Sec7 (HDS) domain 1 is required for recruitment to the trans-Golgi network via its interaction with activated arf11.
Sequence:
MTDLEIETVSRVSSNPDEVKGSSVVEEEPDSESTIKSRVSDEIDEHDSIPEQSNTEKSIEINDKNLEAEKDIESNLSLRPPEDDLDSRSIESEQTGTLSKQTTSTSEAPQDLKIWKNISNASNQNSGKLNPQLFVIEAFKHMSKAKATKRHKKLREAINNVQIELQKQPFLLPEVILEPLVMACQTNSTTLLTITLDCFAKLIDYNYFDSPTLNPSDITLMERVVNTIASCFCGESTPERVQLQIVKALLAAITSERTIIRHSFLLTAVRQTYNIFLLCKDSTTQAIAQVALLQMVDSVFQRLSTVLNHEREFSTINMNKSSSNGTPDRANSPIPSQLSENKLTLESFEHRKSFDQVREEAPLEEDSLEQQLLRDAFLLIRALCKLSIKNIPYEHEYDLKSQSMRSKLMSLHLIYHILRTYMNILSDINVKIRSPTSTPTPLIDAVKQYICLALAKNVVSHVLPVFEISCEIFWLILSELKNFFKSELEVFFTEIFFPILEMRTSSNQQKIVLLNIFHRMCEEPQTLIELYLNYDCISGNTENIYERAIVTLSRIASQSTSDPPPSFVFRDDQLVIDKPGFVYHTLNDIPQLNSSTIGSYVHSHNPPYFDYQIRLKSYRCLISTLSSLFTWCNQTFAPTVEITAKDDETESTSKGEEPQKSKSEPPSAGINSTSMDNLESSGQALATDDPSQFENLKHRKKQLQEAIQKFNYKPKEGIKILLSSHFIASKTPTDIAKFLISTEGLDKAVLGEYLGEGNDENIAIMHSFVDHMSFNDIPFVNALRSFLQKFRLPGEAQKIDRFMLKFAEKYIDDNLGVFKNADTAYILAYSIIMLNTDLHSPQVKNRMTCQDFIKNNRGVDDGANLSDSFLTEVYEEIQKNEIVLKDEQDPTSNFPEIPGTSNLSFAANISNALATVGRDLQREAYYMASNKMANKTEALFKDLIREQRERGKLSGNDIYYTARHFEHVCPMFEAVWMPILAAFSEPLQLSSDPALIQLSLDGFRLAMNVIFFFSMDLPRNAFMQTLTKFTHLNNTSELKWTNMHALKTLLEISLAHGDKLRDSWKDVLLCISQLERVQLISAGVDINSLPDVSTTKPLRKSLDKNIRQSRSGSISLKHSKSFQSASTHSTKSSSVEIVREYSSREVVMAVDMLFSNTRNLGSEGIYDFVKALIEVSWEEIECSLELSNPRLFSLQKLVEISYYNMRRIRMEWSSIWSLLGTYFTQVSCHENSIIASFALDSLRQFSMQFLEIEELSHFKFQKDFLQPFSHAMENSQDLKIKDLVLRCIDQMIKARYQNIRSGWRTIFHILAYASKIENLLVLQCAISVVSSLGHEHISCVLTQGAYIDLISCITKFAKLNGNQKFCLSCVDMLKNLEHELIKHLKHMKKESVYSKKLEEEYWLPFLLSFNEIICEASDLEVRSKALKVLFDCLYRHADDFDEEFWETVSNKALLSIFSILSITNSQRLYLAKNTEETEVWMLTTMVEALKAFIELIKNLFERLHFLLPKALNLLEKCICQENSMISKVGLSCFSQFVLKNKNQFKDVDWDEIINSINQLLQMTLPIELRDPSLYPQVNSDSSLEDVKENSFRPHEISRFNSQSVFKSKKHHLKSIVVKCTLQLLMLNCLWELFHSDNMLTNIPKRKMVKLLDILKQSWEFAESFNSDFEIRAKILSSGIVEHMPNLLSQEALCAKLYFYTAFECMSSLKSDSHDTEEYNDLMDVFQKKIYLASQLVLHGFQRVIGDNPVKGVAAFQPVIAALVSYINSLDEIQFSRGKSEFYQLLCAIVACGHIDQQLGTSLSNAFLRYAC
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDPTTAALAEYISNLTPTDIECRQAIRDFIHAGADTTITFKNLTTLEPSTPQLEESLKDQQNDSGSSLLHLAASRGNFECVQTLLQEAHLSWNILDSNNVSIGEVAKKAGFDSLYDRLVDEGVRTEFLLFVLGQRVVEDVVSNASYLTRKLIYSDGRLLDSDGNAVMMGWEAPLMLKHAQAILPKPGLDVLNVGFGLGIIDEYLQELHPASHTIIEAHPDVYQHMIDKGWDKKPGVRILFGRWQDVLENLETYDGIFFDTFGEYYDDLKDFHQVLPNHLREETGIYSFFNGLAGTNQFFHDVSCKMAQLDLAEIGLSTEFVELSVSELGDDVWQNTKRAYWSLPIYRLPISRIEL