lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
High-affinity transporter for the intake of thiamine.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MEMNGAPTKSKSRLVPVGTWLLPTCLLCAYGFFANLRPSEPFLTPYLLGPDKNLTERQVFNEIYPVWTYSYLALLFPVFLATDYLRYKPVIVLQGASLIISWFMLLYAQGTLALQFLEFFYGIATATEVAYYSYIYSMVEPSLYQKVTSYCRTATLTGFTVGSIVGQLLVSLANWSLFSLNVISLTCVSVAFATACFLPMPTKSLFFHQNLLYPGDKEMYISDKIQVDSNDYALANTTEAEEIESRIALNSEIRSESDVKNCSPKNSNDLQSVLKTFRKYFLHCYSSRTLVCWSAWWALSTCGYCQVVNYAQGLWEQVAPSSHSDIYNGSVEAASTLLGAVAVFAVGYINTSWSTWGELLLAFFSVILTITVYIMDTIRNIWVCYVSYVFFRSIYMLLITIATFQIAANLSMECYALVFGVNTFIALLLQTFLTLIVVDSVGLGLDIFTQFKIYAGYFTAISLIFFYEWTLPCTEKMQKAANYGLIIGSLK
The following text describes a protein:
Function:
Shows weak esterase activity with the p-nitrophenol-linked aliphatic ester pNP-butyrate. Does not exhibit cutinase activity.
Subcellular Localization:
Secreted.
Sequence:
MNNRPIRLLTSGRAGLGAGALITAVVLLIALGAVWTPVAFADGCPDAEVTFARGTGEPPGIGRVGQAFVDSLRQQTGMEIGVYPVNYAASRLQLHGGDGANDAISHIKSMASSCPNTKLVLGGYSQGATVIDIVAGVPLGSISFGSPLPAAYADNVAAVAVFGNPSNRAGGSLSSLSPLFGSKAIDLCNPTDPICHVGPGNEFSGHIDGYIPTYTTQAASFVVQRLRAGSVPHLPGSVPQLPGSVLQMPGTAAPAPESLHGR
The following text describes a protein:
Function:
Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis.
Subcellular Localization:
Nucleus.
Sequence:
MEKERQDGLSDKHKFILQYIMCRTAGVDNEQVRELVQEQYGETATVEDVINELNNSLHNFDFKIKRVQDQLDGRLTLHFQNLSGDPVSQMATPYPPVQIELMRKIIEWIMKCDDYQYSLTTLQIQKLSRKEMGLAPSVIESHLHTFERDGWLRQREGIWTFTNHALAELDAYLHNEYESNLYECNACREIVIAGYVCDCGYCLHVYCCKHLAHVNCINCNTPWANATVIGRW
The following text describes a protein:
Function:
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The PCI domain is necessary and sufficient for the interactions with other CSN subunits of the complex.
Sequence:
MEDMQVEKNTEGSSSSSSNNNNNNSISNEFDLETYINNYSGFTKIHRLIFIADNCKQLEVEAYNMALKEVQKTPNLELYNTIINKSHGILELDPVYIENLSKKNSLQLDKLEQDLNTAKSNMVKDSIRFAQNDLGEFYYKIGDHQNALKCFIRTRDYCTTSKHVLAMCFNIIKLGVDTQNYTHAPSYIAKAEQSPDLDNVSNAKLRSVNGLYNLDGSRYKLAARKFIETPFEQSNVFSDIISPQDIAYYGGLCALATFDRNELKKKVIDDPMFKNYLELVPELRELINDFYNTKYGSCLKYLDKMKPILLLDIHLYKHVEILYQRIRSKALVQYFSPYQSVDMNIMASAFNTTVTLLEKEISKLIMENEIQARIDSHNKRLYARKADQRTTTFEKTVQVGSDFQNSSNSLLLRLEMLNNNISTVSNRKDNERGNWENPHHHHQMQHQMFGLFNNNNKF
The following text describes a protein:
Function:
Binds RNA and DNA sequences with a preference to single-stranded nucleic acids. Displays strong affinity to poly(G) and poly(U) sequences. May be involved in tolerance to cold stress.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing RZ1A have enhanced freezing tolerance.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSEDPEYRCFIGGLAWTTSDRGLRDAFEKYGHLVEAKVVLDKFSGRSRGFGFITFDEKKAMDEAIAAMNGMDLDGRTITVDKAQPHQGGAGRDNDGDRGRDRGYDRDRSRPSGGRGGGDCFKCGKPGHFARECPSESSRDGGGRFSSKDDRYSSKDDRYGAKDDRYGAKEDRYGAKDDRYSSKDDRYSSKDDRYGSRDGGGSRYGPDRSGERAGGRSRDGGSRGAPGGERHSRAPYDRPRAGGFH
The following text describes a protein:
Function:
ATP-dependent RNA helicase required for mitochondrial splicing of group I and II introns. Also required for efficient mitochondrial translation (By similarity).
Subcellular Localization:
Mitochondrion matrix.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MFRVTGIATARAVALQPFRAPLGVIRRFGISATASYEFQHGHDMQSRNGSRWDSRRQGDRRSSRWEGRGSDREDGERGSRGGMWRKPQGRRGRTDGAAREGFSLGPNTEVVRVADEAAGVESTPRTLVEEGVLSNELYEMLQSRGFDKLTPVQQKTLKPILQTEHDVVARAKTGTGKTLAFLMPLFQRLLEGPPSENVKAVVIAPTRDLAAQIFNEINEMRNANRKLRRFNAVVMMGGSSRTETFRSLERRRPNIVVATPGRLIDMLEACGPKYFTEVDFKVLDEADTLLEIGFKQALEQINDILNQLNQKGTTHIRTLLVSATLDDKVQSLANSIMNHAKCLFIDTVDPNEQATNENIAQKVVISKDFADNITASLYKIREEASANPKLKAIVFMPTIVAVEYWGELLQSQCRGTPVLLFHGGLSQGRRNSTMKRFRAMDSGILVCTDVAARGMDVSDVQHVYQVGVPTSPDNYIHRIGRTGRAGRKGSSTIFLAEHELCILDILRRKNNVVISDQETFDAAAQELSDVREAFSLDRDRLHDFLLKNLSFYRGSQGEYDFPLEAYISIARAYGTLLGDSNQRLTLSGRMLTTFVPNHPAVCSLFNIIGPVNSKSSYGFRDTNKRHRRGRLDDSGRLEYSKKRHSYARSYSPSISDGF
The following text describes a protein:
Function:
Transcription activation factor positively regulating trichomes development. Has a function nearly equivalent to that of GL1 and can complement gl1 mutants.
Miscellaneous:
MISCELLANEOUS: At least one of the two introns in the MYB82 gene is essential to the protein's trichome developmental function. The MYB-binding box (5'-TAAGCCAGTTATGTCT-3') located in the third exon of the MYB82 gene is required for MYB82 function in trichome initiation.
Subcellular Localization:
Nucleus.
Domain:
The N-terminal domain is necessary and sufficient for dimer formation. The C-terminal domain is responsible for the transcription activation function.
Sequence:
MECKREEGKSYVKRGLWKPEEDMILKSYVETHGEGNWADISRRSGLKRGGKSCRLRWKNYLRPNIKRGSMSPQEQDLIIRMHKLLGNRWSLIAGRLPGRTDNEVKNYWNTHLNKKPNSRRQNAPESIVGATPFTDKPVMSTELRRSHGEGGEEESNTWMEETNHFGYDVHVGSPLPLISHYPDNTLVFDPCFSFTDFFPLL
The following text describes a protein:
Function:
Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MRLLVWRALLAAGLALALVLAIQLGQQVLECQAVLGAPQNPWQAMRPEQEDLVMMGTDYVEYHCGKAMPHIFVGGVPLSCTTLMHVMLDAHLEAWSKSRGEKLRLDEASVTDQALEATMQAFILEVIAKHGQPAGILCNKDPFTLKSSVCLSRLFPNSKSLLMQLVLHPRCSLKLILNFLGITWSDAVLHYEDLIGKPGGVSLFKIEQSTVQVIKPVNLEALIKKTGHIPADMM
The following text describes a protein:
Function:
May be involved in membrane trafficking (By similarity). Required for tip growth in pollen tubes and root hairs.
Subcellular Localization:
Secreted. Golgi apparatus.
Sequence:
MAAFLVMFIFTIALFVALLWVFFKSLPWILRHSAGITLSFQFDGWNCLKDVALQFKKGSIESIVIGEFKANLSQSLVELCATAFIQDPKVIFSICDLKIVTRPSHSSKGPRKPKTRKSSSGGKGKLMLFANIGRFFSVSMTNMVVQTPKATAEIKELELDLSKDRGSGNFFMKLYLLPIFVQIGEPHVTSTHSPEMDSDICLARQTPSKTAEGSSSSSFHCEKISLSCEFGPNRKSSPSIKNVEVDLANAVLNLNEKLLLKNKSSTSAASKGEVIDSSSGNTTSEKPPKQPMNVLVAKHASKFPEKVLFDLTKLEIRFVHQEHDFSIANSIKGFQLRSAKSQSGEDGKEDTCLDFAMELQEMHLFRESEVSVLEMTKFGVFTKVYCPIQESLPVRAEVEIKLGGIMSNIIMTRFEPLLRLHFSRKKKMVLKEERPTIAKSETTGFKAVVWKCATSAPDVTVVLYNPGGSPIYQCGLDSFQATANNMSNRGTVVQMELNELTLCMVDEHKGCLKESLFGLESDPGSLINIRKVRSEWGKKEVLPEGDGSKGKQTLVVDVSEIGLLFSFRSVEALTVNAISSQAYIKSLTGSSSKNKQEKGAHRSKPPSGRGTQLLKLNVERFSLNFAGDSSLENTVIDDPKRVNYGSQGGRIIISVSADGSPRTASVFSTLSEEHEKLKYIISFEILKFGFTLNKEIQSTQVELETAKAIYQEFLEEPHQVSRVTLCDIQNAKFVRRIGGGKEVSICSLFSASNIAVRWEPDVHISMVELGLRLKSLVLTQKLKQHGNRNPEEASTVTGDKQKEEPTTTPNSLDKKKKKESIFAVDVEMLSITAEAGDGVEAEVQIQSIFSENVGIGVLLEGFMLGFCGCRIVKSSRVQISRIPSMPSTSSSVTPATGGTPWDWIVQGVDIHICMPFRLQLRAIDDAVEEMLRALKLVTNAKTKLIFPIKKESSTPKKPGSKKVGRIRFGIRKLIFDIEEEPLQGWLDEHYHLMRKEAYELAIRSKFLDELMSSGNQVPKTGGDESDGEKKISFEGEEIDPQDPAIIQMMNEKLYKQSFSSYYKSCQSLRLSDGSGACKEGFQAGFKMSTSRTSLLSVSVTDLDLSLTAIGGGEAGMIEIVKKLDPVAEEKDIPFSRLYGSNLRLNTGTLAVQIRNYTFPLLSTAFGKCEGCLVLAQQATAFQPQIIHDVYIGRWRKVQMLRSASGTTPAMKTYLDLPIKFQKGEISFGIGYEPVLADISYAFTVALRRANLSLKGPGLLQPPKKEKSLPWWDEMRNYVHGNVTLSFSETKWIVLGSPDPYEKLDKLHMTSGSVEIQQYDGRVHFSAEDIKIFFSSFEGLARHYPNSPVCPSSYPFLEVPRFSLEVRMDWECESGSPLNHYLFALPIEGKARDKIYDPFRSTSLSLRWDFTLRPENPSVSAVDQTKKVGSECKPEKSSFSPPTINIGAHDLAWLIRFWNMNYLPPYKLRTFSRWPRFGVPRIPRSGNLSLDRVMTEYNLRLDVTPICIKHMTLDSNNPAKGLTFDMTKLKYEICFSRGNQDFTFECKRETLDPVYQGIDLHLPKAFLRRDQHCSKPAQMSRTSSLSGSTDRVTSDNGTSTSDGTEKHPDDGFLFSSDYFTIRRQAPKADPERLMVWKEEGKIYREKVDARSTKEKQSEPEENSHSDPSDDDGYNVVIADNCQRIFVYGLKLLWNIENRDAVLSFAGGMSKAFQPPKPSPSRQYAQRKLLEGNQKHSESEVSQDEPTKQPSTGSGNLASQSKEPAEVLSPSSEPIKTENFASFPLGATKTGDSNDPEEEGTRHFMVNVVEPQFNLHSEDINGRFLLAAASGRVLARSFHSVVHVAYDMIEKAAQNENDHNPENGTDMTWTRMEVSMMLEHVQAHVAPTDVDPGAGVQWLPKIRRSSPKAKRTGALLERVFMPCDMYFQYTRHKGVTPDLKVKPLKELTFNSRNITASMTSRQFQVMTDVLSNLLFARLPKAHNDSLKLSGEEDDEVEEEIDEVVPDGIEEVELAKIELEAKERDRMMLLDDIRKLTQNESNSGNINLEKESDFWMISGGRPVLVERLRKAYLSVQQSRKTAYTALRTSVKNAAELRLLEKDKNKRPSSAMRISLQINKVIWSMVLDGKTFAEVEIDNMIYDFNRDYRDIGIAQFTTRYVVLRNCLPNAKCDTVLSAWNPPPEWGKKVMLQVDARQGAPKDGQAPYELFQVEIYPLKIHLTETMYTMMWEYIFPGEEQHSQRREEVWKVSTTSGSRRRKGSFAQEAAALLAASDLGQGSKNQSLKSSTIRGSGRELRRTSSFDRSWEETVAESVATELVLSSMEHQGESSKGKLKDSKTSKAGGRSVHEEKKGEKSLEDKKSRPQKIMQFQTIKISQVELLITYEGSRFVVNDMKLCMDTFHRVEFSGTWRRLFSRVKKHIIWGVLKSVTGMQMKKFKDKAHVPKDDIGLRDKDESGRTDQESGAWVKRPGDNAGDGFVTSIRGIFNTQRRKAKKFVLRTMRGEAEDNFPGEWSDNESDFSPFARQLTITKAKKLIRRHSKKFQNQNTTKGSKKTQLSPTLSPPKEEDQYESDSSSGSSAYEEFLDQNQI
The following text describes a protein:
Function:
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/NP monomer chaperone prior to the formation of the large oligomeric RNA-bound complexes (By similarity). Regulates RNA synthesis by modulating NP-RNA interactions and interacting with DYNLL1. VP35-NP interaction controls the switch between RNA-bound NP and free NP and thus the switch between genome replication and genome packaging into the nucleocapsid. Prevents establishment of cellular antiviral state, thereby suppressing host DC maturation. Acts by inhibiting host RIGI activation both by shielding dsRNA from detection and by preventing PRKRA binding to RIGI. Blocks virus-induced phosphorylation and activation of interferon regulatory factor 3/IRF3, a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition of host IKBKE and TBK1, producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the host interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR. Increases PIAS1-mediated SUMOylation of IRF7, thereby repressing interferon transcription. Also acts as a suppressor of RNA silencing by interacting with host DICER1, TARBP2/TRBP and PRKRA/PACT (By similarity). As a dimer, binds and sequesters dsRNA contributing to the inhibition of interferon production (By similarity).
Subcellular Localization:
Virion. Host cytoplasm.
Domain:
The interferon inhibitory domain (IID) binds dsRNA.
Sequence:
MTTRTKGRGHTAATTQNDRMPGPELSGWISEQLMTGRIPVSDIFCDIENNPGLCYASQMQQTKPNPKTRNSQTQTDPICNHSFEEVVQTLASLATVVQQQTIASESLEQRITSLENGLKPVYDMAKTISSLNRVCAEMVAKYDLLVMTTGRATATAAATEAYWAEHGQPPPGPSLYEESAIRGKIESRDETVPQSVREAFNNLNSTTSLTEENFGKPDISAKDLRNIMYDHLPGFGTAFHQLVQVICKLGKDSNSLDIIHAEFQASLAEGDSPQCALIQITKRVPIFQDAAPPVIHIRSRGDIPRACQKSLRPVPPSPKIDRGWVCVFQLQDGKTLGLKI
The following text describes a protein:
Function:
Actin-bundling protein. When linked to F-actin the actin filaments form preferentially anti-parallel bundles that associate into meshworks. Plays a major role in cytokinesis. Negatively regulates cortical localization of rapgap1.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MAGKDWEIVQEKAFTAWVNSVLDKRGEKISDVGKDLSDGVKLIFFLELISSKKFNKKYDFEPKARINMIQNVALALKFLDEELKIKVQGIGSEDFVDNNKKMILGFLWTLYRKYRIAVISEGDKSSEEGLLLWCKNTTTGYDGVNITSFTKSFRDGLAFLALSHKFEPESFKFQEFEAMDPIARLNAAFDFAEKGLGVPKLLEAEEVMRGTTDERSLVLYTSLFFHAYRAKEEKARLESSKNEMANRLAGLENSLESEKVSREQLIKQKDQLNSLLASLESEGAEREKRLRELEAKLDETLKNLELEKLARMELEARLAKTEKDRAILELKLAEAIDEKSKLEQQIEATRIRGAAEAQGLGLLRKNLDTHVHDLLKWQKLTMENSSSSSIDDQIIVEVSGLPFGEQVKHLATKLEAENLAIMKLLNQKEDDLKAQKLKSSKSKK
The following text describes a protein:
Function:
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Subcellular Localization:
Cytoplasm.
Sequence:
MSEIFDAKAFLKTVTSQPGVYRMYDAGGTVIYVGKAKDLKKRLSSYFRSNLASRKTEALVAQIQHIDVTVTHTETEALLLEHNYIKLYQPRYNVLLRDDKSYPFIFLSGDTHPRLAMHRGAKHAKGEYFGPFPNGYAVRETLALLQKIFPIRQCENSVYRNRSRPCLQYQIGRCLGPCVAGLVSEEEYAQQVEYVRLFLSGKDDQVLTQLIARMEKASQDLAFEEAARIRDQIQAVRRVTEKQFVSNAGDDLDVIGVAFDAGMACVHVLFIRQGKVLGSRSYFPKVPGGTELGEVVETFVGQFYLQGSQMRTLPGEILLDFNLSDKTLLADSLSELAGRRIHVQTKPRGDRARYLKLARTNAATALITKLSQQSTITQRLSALAAVLKLPAIKRMECFDISHTMGEQTVASCVVFDANGPLRAEYRRYNIAGITPGDDYAAMNQVLRRRYGKAIEESKIPDVILIDGGKGQLAQAKAVFAELDVPWDKHRPLLLGVAKGADRKAGLETLFFEPEGEGFSLPPDSPALHVIQHIRDESHDHAIGGHRKKRAKVKNTSTLETIEGVGPKRRQMLLKYMGGLQGLRNASVEEIAKVPGISQGLAEKIFWSLKH
The following text describes a protein:
Function:
Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues.
Subcellular Localization:
Secreted, cell wall. Secreted, extracellular space, apoplast.
Sequence:
MATDPADTRKQWLLSRDECRCCCSSTRPKILLSIAALALLVTAAVVIGASVGATRASARNHRHKKSSNAATFDENYNISWSGDHVRLLNGGLLADILLDKQSGAEFGSKRSYLFGHLKMQMKLVANDSAGTVTAFYMASHTENRDEFDFEFLGNRSGQPYALQTNIYVNGTGGREQRILLWFDPSLDYHTYSVLWNQYQVIFFVDDTPVRVFRNNSHLGVPYAFSQPMRIFGSMWNGEQWATVGGLEKTNWNYAPFIASFQDFAIDGCDPSSSPGDPGFCFSSGNRNHWWDEEKYRVLDVGQLDNLGSIVRNYTIYDYCTDTKRYSPVPPECGANP
The following text describes a protein:
Function:
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MNQNGEINTKNNEGKNKEQNKDGDKKKVKKLNYDKDELLENDVTKVAGEFDEEKEGNQEMKSFEKMTEKSKKKKDSKKMKNMKKMKKKKKLEKMKNLINSTNNSNNEKDENDFIETFKKKNKKNIKKDKKKTKDTDYEDTVVSSEIHDVITGAGDNSNIYINEEIDESDDEYNINTLGNFDLKHYEDFDIIGYDIEGKKIYKSDENLIDDFLNSQRDENHWRKIKDVKNNRVVQLTDADLQIIKSIRENKVATILNDANYIYENDKEEYKLYPSGIINQKKNEENGSVHERKKISKIMNYLRNKEKYPERYKDKKENDEDYIYDLWNNRIYDEFNNINEISLPHILPGHKYSYNPPPELMLSSSEKRKLLKNNKDAFIPQNFKNIRNIEYYKKTYFDLYQRCLDIYLCSRTLKNVLHINKEDLLPKLPSKKSLKPYPECAFVHYVSNVEEDEKTVDDINKKKMNKNISSYLYPIDINENDHCVYTIYHNKLYIFDILTSYNIATIDLLHYFKSVVPLKTKKKSIEEDIHNNIIIKVNKAYSILAISYTNVVFILHYESYVPPLKSKCETFVDNIYDTTNSDVKRKKPKNGEGNINKANKSKNDALEEESILEGDINDKDGSYHGNNNSDDDGDDNFDDDDENFDDDDDYFDEDDYENFDEDDDNFQSDESYDAGTNNNTENTNNDDISKKKKQVHINRNMVYYKTKGLLSVYHSNFKNSEDYCYSKDINVKWMLLKSNHKKIKYCVAIKHEGEIKDISWNNNGNYLSVTCMRNIGQYNDCYLHHMKTMKSIKLIKKYKHKRGNIISTMFFPRSPYFMVAFENNITIYNLKATNKKERIFKKLRGVQHITSMDVHTNESYILVSDSLGNVFIFDLDLSCNPYKKFHLQECPLKKVQFHKSYNLFYSLGDNGKINLFYSKFFQDYITNPVLLPIKEISNESKIVDMVWSEKKPWFFTYTQNNFSVLYT
The following text describes a protein:
Function:
Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. This receptor binds to the consensus sequence [AG][AG]AAGTCAA. Plays a key role in the establishment of non-metameric domains at the anterior and posterior poles of the embryo. It may also play a role in the nervous system. The maternal terminal pathway activates the tll gene in the termini; TLL activity then represses segmentation and activates terminal-specific genes in these domains. Involved in the regulation of early eye development. In the embryonic visual system anlage drives cells to optic lobe as opposed to Bolwig's organ fate.
Subcellular Localization:
Nucleus.
Sequence:
MQSSEGSPDMMDQKYNSVRLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMNFAQLLFVYESENANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDMYSQRKI
The following text describes a protein:
Function:
Involved in pre-mRNA splicing (By similarity). Functions in association with cyclin-dependent kinases (CDKs) (By similarity). Involved in induction of expression of heat shock protein hsp-16.2 in response to heat shock. Plays a role in male tail development, perhaps acting together with cell cycle regulators cdc-25.2, cdk-1, cyb-3, and cyd-1.
Sequence:
MASFVEMRKLAEAKVQNMIRTIVKPKEQNGNVEPKKEEDEKFESTYKQNENTQITPSSFGKRPLYSKVDINCDKWLMTLDEESRLKIDNPPSLVDGLSKETESELRYLGCELIQQGAILLKLPQTAAATGQILFQRYYYQKSFVRYHFEHAVQACLLLASKIEEEPRRPREVYNVFHRLERLHRLQQSGHDINKETTRGMKPPAVDMNYINTKQHMINSERRILATLGFVVHVKHPHRLIVAYGHTLGITQSRPDILQRSWNYMNDGLRTDIFMRYKPETIACACIFLAARTVENPIALPSTPFHWFEAFDTSDRDVEAIALQLVGLYARRTFPNWPRIKAELDALRSVKDAEMKAVKAKEIAENLAKMAPDGEKSTSTVTIGKDSRKVSPDRKNGTKDRGEADRGKKEKDRHRRRSNDRDGRGDRRDRDKDRGDRRKDEKKDRRKRTRSRSRDRKDKNRNRDVGKRYRKESSTPPRSRR
The following text describes a protein:
Function:
Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.
Subcellular Localization:
Lysosome.
Sequence:
MRLTSSALSFRLLILIFIFSCKALALKPRFLGRNTDQSFSQHRSVSYNTLYIDQQIDHFGFLENGTFKQRYLLNDQHWHKDGGPILFYTGNEGDITWFCNNTGFMWDVAEELGALLVFAEHRYYGESLPFGEESYSNAKYLNYLTSEQVLADFAVLIKALKKSQPGAEKSSVIAIGGSYGGMLAAWLRMKYPNAVVGALAASAPIWQFIVPCGEFYRVVTRDFTISGSNCSSSIRSSWAAIDRLSATGEGLQWLSQTFGLCGPLKSQEDVFGFKAWLQETWVNLAMVDYPYEADFLQPLPAWPVKVVCKNLQFNKGVSDKQLLNGVSQAVRVYYNYTGDAVCLNTSKTATGNLGFLGWFYQCPQILEGCMLCLSDASASFRHWLRRRDMRCSSCTEMVMPMCTDGINDMFEPQPWSFQAFSDECYNQFGVRPREDWAETVYGGRNIHAHSNIIFSNGNLDPWMSGGVTKSLSESLLAIMIDGGAHHLDLRYNNELDPQSVIKARSLEVQYFKQWIKHAATT
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm.
Sequence:
MPSLNQEETPKKTKNPYRKGHSRRQSRHSIPSDELNSNSSKSLNNDRISRTIENSLQKETNSDNKIKKLSKTKSNPTNPKSEEDPSQICQSFDESNIITPSKYLFPLSKDYSPNEGLFQTDMNEKNPHDLWNPTVPMAYLSRSLQGLTISKINETEQKFPLSSVHAYVEIGEGMFSMEIVTEQLRLLGATVHASLQMTEENPVSHAVLYDCSQETLKKISSAQVPIVCVSPKWVLACYSSKYLVDEEMYLVDPQDILQTKCLQTDDSELLNPLDPFTDTQMIQDPSDAFFFDTQAENLEPFVNGSPDSHCFNADSFLDQTLSDDYEFGLITCSDSNESSMSNDAQRENNPETISQISLSPTADLFSSFKITTDLEMTHLESAKKKYLAYKPLIGSPLKKKVSLIDF
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide. Involved in the behavioral responses to esters. Involved in the behavioral responses to pentyl acetate.
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDSFLQVQKSTIALLGFDLFSENREMWKRPYRAMNVFSIAAIFPFILAAVLHNWKNVLLLADAMVALLITILGLFKFSMILYLRRDFKRLIDKFRLLMSNEAEQGEEYAEILNAANKQDQRMCTLFRTCFLLAWALNSVLPLVRMGLSYWLAGHAEPELPFPCLFPWNIHIIRNYVLSFIWSAFASTGVVLPAVSLDTIFCSFTSNLCAFFKIAQYKVVRFKGGSLKESQATLNKVFALYQTSLDMCNDLNQCYQPIICAQFFISSLQLCMLGYLFSITFAQTEGVYYASFIATIIIQAYIYCYCGENLKTESASFEWAIYDSPWHESLGAGGASTSICRSLLISMMRAHRGFRITGYFFEANMEAFSSIVRTAMSYITMLRSFS
The following text describes a protein:
Function:
Multicopper oxidase; part of the gene cluster that mediates the biosynthesis of elsinochrome C, a perelyenequinone phytotoxin structurally similar to cercosporin. The first step of elsinochrome C biosynthesis is performed by the polyketide synthase elcA which catalyzes the formation of nor-toralactone. The starter unit acyltransferase (SAT) domain of elcA initiates polyketide extension by the selective utilization of acetyl-CoA, which is elongated to the heptaketide in the beta-ketoacyl synthase (KS) domain by successive condensations with six malonyl units introduced by the malonyl acyltransferase (MAT) domain (By similarity). The product template (PT) domain catalyzes C4-C9 and C2-C11 aldol cyclizations and dehydrations to a trihydroxynaphthalene, which is thought to be delivered to the thioesterase (TE) domain for product release (By similarity). The bifunctional enzyme elcB then methylates nor-toralactone to toralactone before conducting an unusual oxidative aromatic ring opening. The next step in perylenequinone biosynthesis is an O-methylation at the nascent OH-6 of the elcB product performed by the O-methyltransferase elcD. The oxidative coupling of the two monomeric naphthol units in perylenequinone biosynthesis is catalyzed by the FAD-dependent monooxygenase elcE and the multicopper oxidase elcG. ElcG might catalyze the first intermolecular coupling in a regio- and stereo-selective manner via a phenol radical coupling mechanism and the elcE could forge the second C-C bond intramolecularly via a hydride transfer mechanism. The fasciclin domain-containing protein elcF might also play a role duting this step (Probable). The last piece of the puzzle in the biosynthesis of elsinochrome C is the additional annulation by enolate coupling to afford the dihydrobenzo(ghi)perylenequinone system, catalyzed by the FAD-dependent monooxygenase elcH.
Sequence:
MACNILNFLTGLLSLSSTLPSTYFPSCIKPSNSHVSQNPVRFEVHLTPGRANPTGAGFRDVILVNGTFTGPTLRLSRGDNVEFLVRNHLREDTAVHFHGITQSLSPWADGTPGIAQRPIRPGAAYLYRWRADESGVFFYHAHSRGQLMDGMYGAIVIERGEDEPSPFHMISHEASDWELMREAEREVQTLMISDWSQFSFGEVMGVEREANIDFTCMDAIVVNGAGSEYCLERELLNEYTNPLVKFILSHTDEKEITDKGCVPPLRLFQGNYSLHLDTLPPEAFRKCIPGVGGGANHTVTVHSSNRWAALTFINPGGLYPLKVTIDNHPMHVFAVDGHYIYPQIVDQILVNNGERYSVFVKLDQEVGRYTIRIANDLLGQVLGGFAALSYNGVMDDPPHPKPLMNYAGGSLVKNIRVFDEFNTRPYPPKPPASVADRTHKFMVRKLAQPHGAYEWTMSGIEGLNMTTEDVASPFLFQDPSQIETSELMLTTKKNEWVDLIIEVEGPFAQSHPMHKHGNKAFIVGRGVGFFPWATVEEAEKHLPRGTFNFIDPPYKDTFKTLEGVNNNAWLALRYHANSPGAWLFHCHIQTHLAGGMGVVILDGVDEWPELPEAYAEWNGFEAPV
The following text describes a protein:
Function:
Required for the trans-splicing of intron 1 of the mitochondrial nad1 transcript encoding the ND1 subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I).
Subcellular Localization:
Mitochondrion.
Sequence:
MKRLFSKSLCTSAAGANLKPPPADSAAIAKLILSSPNTTHQDDQFLLSTKTTPWTPNLVNSVLKRLWNHGPKALQFFHFLDNHHREYVHDASSFDLAIDIAARLHLHPTVWSLIHRMRSLRIGPSPKTFAIVAERYASAGKPDKAVKLFLNMHEHGCFQDLASFNTILDVLCKSKRVEKAYELFRALRGRFSVDTVTYNVILNGWCLIKRTPKALEVLKEMVERGINPNLTTYNTMLKGFFRAGQIRHAWEFFLEMKKRDCEIDVVTYTTVVHGFGVAGEIKRARNVFDEMIREGVLPSVATYNAMIQVLCKKDNVENAVVMFEEMVRRGYEPNVTTYNVLIRGLFHAGEFSRGEELMQRMENEGCEPNFQTYNMMIRYYSECSEVEKALGLFEKMGSGDCLPNLDTYNILISGMFVRKRSEDMVVAGKLLLEMVERGFIPRKFTFNRVLNGLLLTGNQAFAKEILRLQSKSGSRLLRKFRL
The following text describes a protein:
Function:
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane. Cytoplasmic vesicle. Membrane; Single-pass membrane protein. Nucleus envelope. Nucleus inner membrane. Nucleus outer membrane.
Domain:
The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
Sequence:
MERSAWAGPGRGRTTAGQWAGGGGRGRGSGGGAVGEHAVGAGRAGAAGGAAAGRPGRAAAGPLRRRRRRPARRALPIPAPGRRPAGSPVRRAGPRAGLLQDHRGAAAPAPGTHPGGRGAAVGVRQRRRLDGVHVPAARLPLRVRAALRHRRGLQRPLSGRYWAEISDTLISGTFRQWKEGMTKSEIYYPGETVVHRPGEAAAVQWSAGTWMVEYGRGCIPSTLAFALADTLFSTQDFLTLFYTLRAYARALRLEVVAYFSGQGR