The following text describes a protein:
Function:
Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus. Required for microtubule nucleation at the cis-side of the Golgi apparatus. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. In complex with PDE4DIP isoform 2/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with PDE4DIP isoform 2, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Incomplete sequence; MISCELLANEOUS: [Isoform 3]: Incomplete sequence.
Subcellular Localization:
Golgi apparatus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in parietal cells. Recruited to the Golgi apparatus by GM130/GOLGA2. Localization at the centrosome versus Golgi apparatus may be cell type-dependent. Recruited to the centrosome in the presence of CDK5RAP2.
Domain:
RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Sequence:
MEDEERQRKLAAGKAKLARFRQRKAQYDGDIPKKQKKKRTSSSKHDSSLHTDQQSGELCSESSQRVDLAGNPDCSGPERKHGQVFSAEPESEISTTADECSSEINGCNSVMKPRKPTDPLREEEFSLDDSSSEQGAQSSQTCLQMVEKELAEKQHDIEELTQELEEMRASFGTEGLKQLQEFEAAIKQRDGIITQLTANLQQARREKDDTMVEFLELTEQSQKLQIQFQHLQANETLQNSTLSRTATDLLQAKRQIFTQQQQLQDYQKKEEDLQAQISFLQEKLRAFEMEKDRKIENLNAKEIQEKQALIDELNTRVVEEEKKTVELKNKVTTADELLGGLHEQLTQRNQEIQSLKLELGNSQQNERKCSEEIKELMRTVEELQKRNLKDSWLETSAVRRVEQETQRKLSHLQAELDEMYGKQIVQMKQELINQHMSQIEELKSQHKREMENTLKSDTNAAISKEQVNLMNAAINELNVRLQETHAQKEELKGELGVVLGEKSALQSQSNDLLEEVRFLREQVQKARQTIAEQENRLSEARKSLSTVEDLKAEIVAASESRKELELKHEAEITNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQPLFSHEEELSKLKEDLEVEHRINIEKLKDNLGIHYKQQIDGLQNEMNRKMESMQCETDNLITQQNQLILENSKLRDLQECLVNSKSEEMNLQINELQKEIEILKQEEKEKGTLEQEVQELQLKTEQLEKQLKEKEDDLQEKCAQLDAENNILKEEKRVLEDKLKMYSPSEQEERSIAVDPSTSKLADSRWQKEVAMLRKETEDLQQQCLYLNEEIEKQRNTFAFAEKNFEVNYQELQREYTCLLKIRDDLEATQTKQALEYESKLRALEEELLSKRGNPXAPKGKSSGIFPSETLEIGEVVEKDTTELMEKLEVTKREKLELSEKVSGLSEQLKQTHCTINSLSAEXRALKQEKEQLLLRCGELELLANPSGTENAAVCPVQMSSYQAGLVMGKVGDSGGSISKISKDLAEESKPMIEDKIPFKESGREQLLLPTRAQEPSHATVEPCESEKLQQELHALKAEQDDLRLQMEAQRICLFVVYSTHADQVRAHMEKEREEALCSLKDELISAQQKKIDELHKMHQCQLQNVKIQETGDEPLQVLIERLQKAVSEKCFHISKTLNNVFDECYTPLKCEMNIEEKENSGVYTSQNQSPELQEYRYEVQDFQESMQVLLGKVTEECRKLSGLQTRLGKIHEQQTDGVALEFAEQNAAEEEAGLLSGCSQSALQSTDVSLESKVSSLPASEKNRECERQVQELQSPVAAGQLQLTETEASHRAEIECLQQRLEAASEAPVQPSLSIDSVVFKGSGAQKPVYCGSCLREYVDGTAKFSDRFEVRQETNMVNLMEKQYQERLEEEIAKVIVSMSIAFAQQTELSRLSEGKENTIQSEQAHTLCSQNKHQLNDITSQSQVGLQTFEATDKBFKEEFKPLSKELGEYRKAVPLSSHDDLDDILKSEEHGLAISEEIFSKDETFIVRKSMHDEVLVSSMDTSRQLILNEQLEDMRQELVRQYEEHQQATEMLRQAHMQQMERQREDQEQLQEEIKRLNEQLTQKSSIDTEHVVSERERVLLEELEALKQLPLAGRKELCCELRHSSTQTQDGHDDQEVEEQTLKDKTLERSPEDALLDRNLSNERYALKKANNRLLKILLEVVKTTSAAEETIGRHVLGILDRSSKGQTASSLLWRSEADASATTCAPEDCARAMDESIPSYPGTAIATHDSIWSKVTEEGAELSQRLVRSGFAGPVIDPENEELMLNISSRLQAAVEKLLEAISETNTQLEHAKVTQTELMRESFRQKQEATESLHCLEELRERLQEESRAREQLAEELNKAESVIDGYSDEKTLFERQIQEKTDIIEHLEQEVLCMNNRLQELESDQRRVEEERQLLCRQREAMRAEAGPVEQQFLQETEKLMKEKLEVQCQAEKVRGDLQKQVKALEIDVEEQVSRFIELEQEKNAELTDLRQQSQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEHQLKAAPRIQPVSEHQAREVEQLTNHLKEKTDRCSELLLSKEQLQRDIQERNEEIEKLECRVRELEQALLASAEPFPKVEDQKRSGAVAADPELSLEVQLQAERDATDRKQKEITNLEEQLEQFREELENKNDEVQELLMQLEIQRKESTTRLQELQQENRLFKDEIEKLGFAMKESDSVSTRDQPMLFGKFAQLIQEKEIEIDRLNEQFIKLQQQLKLTTDNKVIEEQKEQIQDLETQIERLMSEREHEKKQREEEVEQLTGVVEKLQQEVVSTEQQREGARTLPEDEESFKHQLDKVTAEKLVLEQQVETTNQVMTHMNNVLKEINFKMDQITQSLCNLNKECASNEELPSLPKESVHMTVHELGSDNLQPEDAPAQDVTKPLEKQTSLTRLQESPEASRTQEIESLASSVGAKDVELTQCREQTETIQEQAQSETDRLQKKLTDLQRSLEKFAAALVSQVQMEAAQEYVPFHQEKQPVSSAPGSTDIQNANGLTGASTESLIPTVTLRLAEVESRVAEVHSGTMSEKLVGIVGGNASETEKRVIELQKLLEEAEERPEEGGEQSSRDGEVRESYMTSLQKDLGQVKDPLTEAKEKLSYSLEKEKRTGEQESREAPIPEPPSVEVGGCSGLTERTDKVSSSGNQTLQILLRDAAIQTDLQSESSQEEVRDTINQLTKKMEHIQELHAAEILDMESRHILETESLKKEHYVAIQLLTKECETLKEMTQCLRCKEGSSIPELADSVAYQSREVYSSDSESDWGQSQGFDTAIEGREEGETSADLFPKKIKGLVKAVHSEGMQVLSLSSPLCDDGEDRSIQQLSESWLKERQAYLNTISSLKDLISKMQVRRETEVYDRCHLSDWRGELLLACQRVFIKERSVLLATFQTELTSLSTRDVDGLLNSLEQRIQEQGIEYHTAMDCLQKADRRSLLAEIEDLRAQINGGKMTLEREQGTEKSSQELLDCSMQQKQSLEMQLELSSLRDRAAELQEQLSSEKMVVAELKSELAQAKLELGTTLKAQHKRLKELEAFRSEVKEKTDEIHFLSDTLAREQKNSLELQWALEKEKARSGHHEEREKEELEDLKFSLEDQKRRNTQLNLLLEQQKQLLNESQQKIESQKMLHDAQLSEEQGRNLGLQALLESEQVRIQEMKSTLDKERELYAQLQSREDGGQPPPALPSEDLLKELQKQLEEKHSRIVELLSETEKYKLDSLQTRQQMEKDRQVHQKTLQTEQEANTQGQKKMQELQSKVEELQRQLQEKRQQVYKLDLEGKRLQGLMQEFQKQELEPEEKPGSRGLVDQNLNEPATWNFTDDRTRNWVLQQKMGEAKDRNFTKLIEINGGELDHNHDLEMIRQTLQHVASKLQHVAQKACSRLQFETAGDDAFIWIQENIDGIILQLQKLTGQPGDEHSLGPPSSSCGSLTESLMRQNTELTRLINQLTEEKNTLRSIVIKLEELNRCYWHTGASRDCCSRFSFIDPADIEAIIASEKEVWNREKLSLQKALKRAEAKVYKLKAELRNDALLRNLGPDTDHAALQKIYNKYLRASSFRKALIYQKKYLLLLLGGFQECEDVTLGVLARMGGHLALKDSKTITNHPKAFSRFRSAVRVSIAISRMKFLVRRWQQVTSTSSININRDGFGLSPGIEKTDPFYHSPGGLELYGEPRHTMYRSRFDLDYPRSLLPLQNRYPGTPGDLNSISMASSQLHQYNPDKSLTDYVTRLEALRRRLGAIQSGSTTQFHFGMRR