lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines.
Subcellular Localization:
Cytoplasm, myofibril, sarcomere, Z line. Nucleus.
Sequence:
MGQEISQHTEASNDMQDESIEASSSISQILGESYSAETKIHQESIEQSLSISSSHSYHHSVCSNRVDDLCEADDLTDLSAFLNQEELDQSVHLARQAIDQDGNQKAVQIDIKCPPKEQSRPVVRPPVTRPSKPTLSDREQEFYQGQVIKGSNNSTEGTKDLKKPQRTTPYGIETESKKEFLNKAADFIEELSSLFKANSSKRIRPKTLKNRRSKRDLKSGTLEQDISNYTSQLENRERQNYTPEKTEINTSISEEANSLEALDPESEKESLQVENDTQCSSFYFKEPVGQPPNFIQKLKSREVTEGSKVQLDCIVVGFPPPEVRWYCEGKELENSPDIQIQKSGDLNSLVITEAFEEDTGRYSCFASNIYGTDSTSAEIYVEGASSSESEGDTIKTEADQADPSAPETNVSNADTYQEMNNPPSNIQTMQPTVIQQCQSPSTYLQGLDGRPLIAAPVFTKSLQDLTACEGQLVVFESRVKGSPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVISEDSGMFTCTASNKYGTTSSIAYLTIKGSNENTSTAPLSISTINIDAFKREPLPSTPEPVAIVNPPPKPKLEGVLVNHNEPRPSSKIEKRVHFKLPEDDKGSETSSEEGVTSQKHLGPDLPDMTNGQTLGSLGPSFKEPPPVFAKPKLDPVKLQQLHNQVMIEQQQQPSTPVSLAKDTTYSTPVQNSTGAQPYMFARPQQFIFGPDPINSTPVSSKFTFSTTGTRPWISNRENIPEVSTEVGPSTAKTEPSTATESIFSSPPSALKRQFQAQIVSPTPISPPRIQNPAAFLSSVLPSLPSSPPPTPTNAMGLPKTSPLSAPGAAKKNLKTVRFESEDQIQENKDFVVKELERKLSFRASTPQYTPRQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIHHDEIPTGKCIAPIFDRRLKHFRVVEGTSVTFTCKVVGIPIPKVYWFKDGKQISKKDQHCKMQREADGTCALYIEAATNDDDGNYTIMAANPQGRISCSGHLLVQRAPFRPRSLLPVQSHRVRPRLPEAESEIVEERFFRPYFLQAPGDMVAHEGRLCRLDCKVSGLPTPDIMWLLNGRQVKLNATHKMLVRENGIHSLLIDPLTQADSGTYTCIATNKTGQNSFSLELSIVAKEVQKAPVFLEKLQNCGVPEGHPVRLESRVVGMPPPVFYWKKDNESIPANRQRISMHQDNTGYVCLFIQPARKEDAGWYTLSAKNEAGIVSCTARLDIYAQWYQQIPQSIKKTRPTGSRYSMFSALDAIISHPPVITPLSYSSKTLEVVESEEL
The following text describes a protein:
Function:
Large subunit of the propanediol dehydratase-reactivating factor (DDR), which reactivates suicidally inhibited adenosylcobalamin-dependent propanediol dehydratase (diol dehydratase, DDH) found in the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation. Reactivates inactivated DDH in the presence of ATP, Mg(2+) and free adenosylcobalamin (AdoCbl), by mediating the exchange of the tightly bound damaged cofactor AdoCbl for a free intact one. This subunit contains the adenosine nucleotide binding site; The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
Miscellaneous:
MISCELLANEOUS: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate. BMCs can constitute up to 10% of total cell protein.
Subcellular Localization:
Bacterial microcompartment.
Sequence:
MRYIAGIDIGNSSTEVALARQDETGALTITHSALAETTGIKGTLRNVFGIQEALALVAKRAGINVRDISLIRINEATPVIGDVAMETITETIITESTMIGHNPKTPGGAGLGVGITITPEELLTRPADSSYILVVSSAFDFADIANVINASMRAGYQITGVILQRDDGVLVSNRLEKSLPIVDEVLYIDRIPLGMLAAIEVAVPGKVIETLSNPYGIATVFNLNADETKNIVPMARALIGNRSAVVVKTPSGDVKARAIPAGNLELQAQGRTVRVDVAAGAEAIMKAVDGCGKLDNVTGEAGTNIGGMLEHVRQTMAELTNKPSSEIFIQDLLAVDTSVPVSVTGGLAGEFSLEQAVGIASMVKSDRLQMAMIAREIEQKLNIDVQIGGAEAEAAILGALTTPGTTRPLAILDLGAGSTDASIINPKGEIIATHLAGAGDMVTMIIARELGLEDRYLAEEIKKYPLAKVESLFHLRHEDGSVQFFPTPLPPAVFARVCVVKPDELVPLPGDLALEKVRAIRRSAKERVFVTNALRALRQVSPTGNIRDIPFVVLVGGSSLDFEVPQLVTDALAHYRLVAGRGNIRGSEGPRNAVATGLILSWHKEFAHGQ
The following text describes a protein:
Function:
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Subcellular Localization:
Mitochondrion.
Sequence:
MLLKTGMSVCLTARHFQLTSMMRLMTTAAATSSKANLAKLRRKTGFSFVNCRKALEKFSNDVDQAEVWLREQAQKEGWSKATKLQGRVTAQGLIGVMCQTNSAIMVEVNCETDFVARNAKFQNLVSHVASAALFSKKGQHEDQNILKLPLSAEDLKSSVGDDGKTMEDLAALTIGQAGENMSIRRGLYLEAPQEFFIGSYVHSALQKSKEENQSKCTMGKYAALVVFKKLGETTTNFRPEVLGRRLSQHVVGMNPLRIGVYSPPDPEDLKSQEMAQPPQSDQSESDPSDEHASVPSSTETETDEMVNQEYLLDPSLTVGELLLQENVEVVDFARFECGESTGDS
The following text describes a protein:
Function:
Catalyzes the reversible NAD(+)-dependent oxidative deamination of L-phenylalanine to phenylpyruvate.
Sequence:
MSIDSALNWDGEMTVTRFDRETGAHFVIRLDSTQLGPAAGGTRAAQYSQLADALTDAGKLAGAMTLKMAVSNLPMGGGKSVIALPAPRHSIDPSTWARILRIHAENIDKLSGNYWTGPDVNTNSADMDTLNDTTEFVFGRSLERGGAGSSAFTTAVGVFEAMKATVAHRGLGSLDGLTVLVQGLGAVGGSLASLAAEAGAQLLVADTDTERVAHAVALGHTAVALEDVLSTPCDVFAPCAMGGVITTEVARTLDCSVVAGAANNVIADEAASDILHARGILYAPDFVANAGGAIHLVGREVLGWSESVVHERAVAIGDTLNQVFEISDNDGVTPDEAARTLAGRRAREASTTTATA
The following text describes a protein:
Function:
Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGDKPIWEQIGSSFVQHYYQLFDTDRTQLGAIYIDASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSITAEDHQPTPDSCILSMVVGQLKADEDPIMGFHQIFLLKNINDAWILLTLMEHSKYHTQICNTMASQQDL
The following text describes a protein:
Function:
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
Sequence:
MPQDRFVASDSIASRVQQLVDEINRHNRLYYDDAAPEITDLQYDQLLAELTQLENDHPDLRRPDSPTQLVGGDVVDQLVQVPHRVPMLSIDNTYSREELAAAMERIEKSLEGESVAWTMEYKIDGVAGSIRYENGELTLALTRGNGQVGDDITHNVRTIRELPRSIADAALAHPEVAGGNVPEVLEVRGELYMTDADLADLNVRQTDAGHEPFKNTRNVTAGTIRLLDPKIAASRNIRFFCHGSGELVGVRASDHMTFLQHVQALGIPIAPDVVRFENKEDALQAIAKLELEMPDLPFEIDGIVFKVDSFEQREKLGVRSKSPRWVIAYKFERYEAITTLEAIDVQVGKTGTITPVAYLTPVDIADTTVSRASLHNADEIERLDVRVGDTVVVEKAGKIIPKVVRVEKHARTKPLPKFEFPTHCPQCDEVLTRDEGGVYIRCTNPACPAQLRQRLVYFGSRTGMDIDGLGEEVVDLLLQKELVENYADLYRLNVDELAELTWPRLRKGKGDEMIEVQFGRKNAESLVAGINESRTRGLARVLSSISIRHIGPRVAKLITAKFWNLDLLRSAKAEDLAAIHEIGDRIAESLVKFIHSESGSQTLSDLDAVGVTMSETEPVATPDEEANLPLAGKNIVATGTLQHYTRDEIKARIEELGGRAASSVSKKTDFLIAGEKAGSKLTKAESLGVEVLSEDDFRLRYETEAT
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
Miscellaneous:
MISCELLANEOUS: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
Domain:
Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.
Sequence:
MAFIALGINHKTASVAVRERVAFTPEQMVEALQQLCRLTTSREAAILSTCNRSELYLEIDHPTADDVLAWLADYHRLTLDELRACAYVHQDEDAVRHMMRVASGLDSMVLGEPQILGQMKSAYAVAREAGTVGPLLGRLFQATFSTAKTVRTDTAIGENPVSVAFAAVSLAKQIFSDLHRSQALLIGAGETITLVARHLFEQGVKRIVVANRTLERASLLAEQFGAHAVLLSEIPEELANSDIVISSTASQLPILGKGAVERALKQRKHKPMFMVDIAVPRDIEPEVGELDDVYLYSVDDLHEVVAENLKSRQGAAQAAEELVGSGVAEFMQRLRELAAVDVLRAYRQQAERLRDEELGKAQRQLANGADPAEVMAQLARGLTNKLLHAPSVQMKKMSAEGRIDALALAQELFALDEGAPRH
The following text describes a protein:
Function:
Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAESGENFGHVLVLMFLLIGVWDVFQNVETNKCEMTYMWELPEYYKIPMQGNVSKQFSSYSLYIYGEGAYMKEAMKLKLDGIPVLFIPGHGGSHQQARSLGSVLLRKAMSGGFNNHFNVFTADLGEELTAFYGGNLGHQTKYIGHCIKRILSLYEYAKHKPTSVILVGHSMGGVIARGVFAIPDFNQNQVKTIIMLASPVLAPVLNVDRYMSQYYAKTNQYWLEHISKLRDVNTISIGGGPRDFQVSSGLTRLSSNQSNYLSTITTAVPRVHLSTDHQCIVWCKQLVMATVRYLFDITDPKSHQVVVDVQQRVRAMEYHFKKHPGYGSVANRDSPQKFKPSSAYTWKPVSDFLWSLNKEEAGSGSYFTFDITHFVKQFTYHLVARTDSVREKWVLACKQAVNEKCVEATDLSYSSTGMMRYRIIHLDLRVLEEQGFTYVVFPASKVKEGKVLGVNILSDHEISSEVGVPHVFSNLWTFGAGYKHSIAMHGAENRFYYKTVLKDFQAIYQVFKLDFPKGAVLKTEIPWDKGQEDIQKTSIVVKLRNTPHDLEDNVVVHIYMDTPGPVDLQIKVQYFEVLGQIVRYFYMMLPVFVLCNVMFTYCYQVNQMQLGKPCHSLYDAHSISSKPYKVQPFISLLKLFFGYQWFKLLWYNVGLPTPDSIILETDHRMWFTMAPLILFLYGFELFSITRVMQVYAIKLLGKIFGGFDNLLTGPKYLYLIFHSVVLSLLLQVNSSFALLYILLAYYGKLMLLYNVADMDKLNNTPYIKEDTTDKEDKADDGKDKDVANTDANKVKGKKEPKPTRLTEDEFSVNFIVVQLYLWLFIFTLPSFAGFIQNYRLNLPFSDPWKIQSAIGSMLFLLTNVHGTYDGIMASNLKQSSKFLLPIVVLMAVTSIFSLYRHISTLYCFILFLCCVCCFL
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MKRTANQLEQQQQEQEQEQQETERPTVQRVKFNLNSSDSEEEEEEQNNDENKENRAETTGFLTAKNPSDAYFLAHGKTNPTSTTLLSERKKHEQIQLTDYLDPFDPQPLRSAESNWDQWTAELIEGYSILFYGLGSKRSTLNQFVEKHLVASLGWEGLVVNGFQNGCELSNLLHDLEEIIDQNDSPDDHDDQGFTQPVANKRSSSLETLELRAQALCGRLAKKKKEEEEEGPECVLMIHNLDGIGFRNPRIQTILGLLTGQPTIHLIATIDHINAPILLSSHLSSARPTSLEHTNQLLESFPSTYNFLYHHLATPTPYTLESLLSGTVSSLLPASIFPSVMVGNQKTIKSEILNNGLPSLQATLHVLSSLTEKSKALFRLFAEYQLQQLLALPPLEATRVDHEIAGKTPADHDHQITPCVAISIIALYELARADFIASALSQLHALLVEFRDHSIIRSRFSPPPTSVSSSSATAANPNPVDLEPIDEQQEWIWIALSKADLEDILAQLDQL
The following text describes a protein:
Function:
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Sequence:
MSDKKMTSSRRHHLKSLILQVAQGMLEQEKADIEAAKEAYMAEHCPAPDMNGDQAALMEVCKKLHSALDKIDEDRYDAEAKVLKANKEIEDLKIKVVDLVGVKKPALKKVRMSADTMLKALLGSKHTVTMDLRANLKQVKKETKEEVKKCLSVWSLSWNKSVEYTPFFVFCSQQKLWVTGVRTLRTKLTGRRCSSLPNCSVAVCFFVSIISAVG
The following text describes a protein:
Function:
Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization.
Subcellular Localization:
Nucleus.
Sequence:
MVMILRRSLINQGADSGAHRTFIPELHTPKMSQGPTLLSCGIMENDRWRDLDRKCPLQIDQPSASIWECLPEKCQDGSLWHQEAVTACAVTSLIKDLNINDHNGNPSAPPSKRQCRSLSFSDEMSSCRTSWRPLGSKVWTPVEKRRCYSGGSVQRYSNGVSPMQRSSSFSLPARANGLSSPCHQSSLHHRFGGQPCQGAPGSAPCGQAGDSWSPDPHPVGGGRLDLQRSLSCSHEQFSFPEYCPPSANSTPASTPELARRSSGLARSRSQPCVLNDKKIGVKRRRPDEVQEQRPSLDLAKMAQNCQTFSSLSCLNMGVDDHSSQSPFALVSSTRSWTALLSASSPGGRTPAGTPVPEPVPHSFDDQFTCQEDLSCDESDGCSLDEDCCRKGDPATSWRDRGACTNSLCSLDGELDIEQIENN
The following text describes a protein:
Function:
Involved in the synthesis of glucuronoxylan hemicellulose in secondary cell walls.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MKCLALSDAMGSFSLECHILHLFLFSNICSKIHFLALPFSTAAAPLPERNVSAAGDGSRVVVGRHEILIRSWPHPDPAEFEQRSQYELKRPRIVIAITLTYVQTFQALHLTGVMHTLINVPYDLIWIVDRHKLELKMRLHALRYILIYRRVVREKKLDGIVMFADDSNMHTLELFDEVQKVMKWIGAVSVGILAQLGGPACNSSNHLAQLHTFDTRPFIDRRARYIGEWAVVLPRKLEWGVFVLNLRLFWEDMRDKIEFAEV
The following text describes a protein:
Function:
Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton. Note=Also exists as a soluble form in the cytoplasm. Associated with microtubules.
Sequence:
MDVNIAPLRAWDDFFPGSDRFARPDFRDISKWNNRVVSNLLYYQTNYLVVAAMMISVVGFLSPFNMILGGIVVVLVFTGFVWAAHNKDILRRLKKQYPTVFVMVVMLASYFLISMFGGVMVFVFGITFPLLLMFIHASLRLRNLKNKLENKIEGIGLKRTPMGIVLDALEQQEENISKFADYISKVNE
The following text describes a protein:
Function:
Involved in the biogenesis of the 60S ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAHYNFKKITVVPSAKDFIDLTLSKTQRKTPTVIHKHYKIHRIRHFYMRKVKFTQQNYHDRLSQILTDFPKLDDIHPFYADLMNILYDKDHYKLALGQVNIAKNLVDNVAKDYVRLMKYGDSLYRCKQLKRAALGRMCTIIKRQKQSLEYLEQVRQHLSRLPTIDPNTRTLLLCGYPNVGKSSFINKVVDTPGILDHPLEDRNTIEMQAITALAHLRAAVLYVMDLSEQCGHGLKEQLELFQNIRPLFINKPLIVVANKCDVKRIAELPEDDQKIFIDLQAEGFPVVETSTLTEEGVIKVKTEACDRLLAHRVETKMKGNKVNEVLNKLHLAIPNKRDDKERPPFIPEGVVARKKRMEIGEPKRKRERDIELEMGDDYILDLQKYWDIMNSSEKYDKIPEIWEGHNIADYIDPDIMQKLEELEKEEELRTAAGEYDSESESEDEEMLEIRQLARQIREKKKLKILQSKEKNTQGPRMPRTAKKVQRKVLENEMRSLGVDMDDKDNAHYAVQARRSRSVTRKRKREDSVPPSSVARSRSCSRTPRDVSGLRDVKMVKKAKTMMKNAQKKMNRFGKKGEADRHVFDMKPKHLLSGKRKAGKKDRR
The following text describes a protein:
Function:
Transcription factor that is vital to the development of multiple organ systems. Binds to the core consensus sequence 5'-WGATAR-3'.
Subcellular Localization:
Nucleus.
Sequence:
MDMTSTAEAAARSWYDSPRLGGGGSSGGGNGGGVSPQTNGLGSAGSSLAHSHHSLSSGASSAGSSVGVGSALGGGGGSGLDTSDMSAFYALESNGHHRRYYPSYHQHTSRMPSTHASPQVCRPHFHTPLSPWLTSEHKSFAPASAWSMGQFACPQEPQVEHKLGQMGQSHQTTAAGQHSFPFPPTPPKDSTPDSVQTGPSEYQAVMNAFMHQQATGSTSLTDASCALDIKPSIQNGSASGSSGSGTTHTSTPKQREEGRECVNCGATSTPLWRRDGTGHYLCNACGLYYKMNGQNRPLIKPKRRLTLQSLQSAAKRAGTSCANCKTTTTTLWRRNASGEPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKLSSKSKKKKGLGGGCLPIGGHLGMGDFKPLDPSKGFGGGFSASMAQHGHLSSGLHPAHAHMHGSWYTGGMGALGASSGLQGGFSTAGSLSGAVVPHSQPYHLGLSSMGTWRTDYT
The following text describes a protein:
Function:
Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.
Sequence:
MAARPASKPSSRSKGRTRPAVCALCQGPYRIPVVFKGQKFCRFCFDHLKNEGAINQPSLEDDSKVKREEVGKEEKDTKEKEVCSQCSEHGENLIWFCVQETMLLCEVCKASGDHAPHTVVPVEDAAQEYKGKLKHAVDLLKQHLEESEKQTYQEGKKTAIWKDAVHSQKERIMSEFYKLHAFLVDEEDKLLKELKEEKRQTLKKLHKNLEQLSVQRSSLKQLVAEVKRKNQQPDTELVKDVENILSRTRNVTRVETETVSVELKNVYNIPCIDVIELLTKFKVDITLDLATAHPSLVISENKKSVKHGGRQQPELLAKENNAERFDTYFIVLGSERFTSGRHYWEVEVGESTEWDLGVCRETVTRKGQVSIMSPLSGFWRLWLRNRDQYKAVISRPTLLPMKVKPTRVGIFLDYSEGEVSFYNVTDKTHIYTYVGTFYTPLRPFFSPSHYQKGEKAHPLAICPGPRNDTTGRKANLEA
The following text describes a protein:
Function:
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. The complex has been shown to be involved in the specific degradation of heat shock induced transcription factors such as RpoH and SulA. In addition, small hydrophobic peptides are also hydrolyzed by HslV. HslV has weak protease activity even in the absence of HslU, but this activity is induced more than 100-fold in the presence of HslU. HslU recognizes protein substrates and unfolds these before guiding them to HslV for hydrolysis. HslV is not believed to degrade folded proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTIVSVRRNGHVVIAGDGQATLGNTVMKGNVKKVRRLYNDKVIAGFAGGTADAFTLFELFERKLEMHQGHLVKAAVELAKDWRTDRMLRKLEALLAVADETASLIITGNGDVVQPENDLIAIGSGGPYAQAAARALLENTELSAREIAEKALDIAGDICIYTNHFHTIEELSYKA
The following text describes a protein:
Function:
Involved in nuclear mRNA splicing. The principal role of the U1A is to help fold or maintain U1 RNA in an active configuration. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP.
Miscellaneous:
MISCELLANEOUS: Present with 2950 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSALYFQNLPSRPANKENYTRLLLKHINPNNKYAINPSLPLPHNKLQISSQPLMLLDDQMGLLEVSISRSSKMTNQAFLTFVTQEEADRFLEKYTTTALKVQGRKVRMGKARTNSLLGLSIEMQKKKGNDETYNLDIKKVLKARKLKRKLRSDDICAKKFRLKRQIRRLKHKLRSRKVEEAEIDRIVKEFETRRLENMKSQQENLKQSQKPLKRAKVSNTMENPPNKVLLIQNLPSGTTEQLLSQILGNEALVEIRLVSVRNLAFVEYETVADATKIKNQLGSTYKLQNNDVTIGFAK
The following text describes a protein:
Function:
Forms chloride channels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane.
Sequence:
MTVGYMKIAATAKLGTFLRLLLRWRGSVWKGVWRELGAWLFIYNWISLLYRFYLRGTENGSRFERLVMGTDLLMSHARTALIFVLGFYVSHIATRWWNVFMEIPWPDTIALSIAAFLHSRPGMEKQDRTTRVNIMRYIVVSYVLVFRDVCERIRLRFPTLKHLKPSMITEEELKMLEQANDEYSFRMWMPIEWSLNLLKKCKDRRQISDVHFVYLTKEILKFRDRLQNIKSFDWINVPLVYSQVVSLSTTVYFLMCLIARQYIAIDHEDIRWRVDYILPYFTMGEFICLVGWLKCAQVMINPFGQDDDDFEVDTLIERNLAVSMSMVDDLYDRAPPLAKIDIKHLPGILDPNKKNPMVGSAVPMKMQVNDMKMVDPNQEKWIKTGAQVADAIYSGMDSSEAPIEDGLSKSGTHPGQSNVGLEDKTKSGEDTSYKKLLAGSPTGKAHQNSQEELEAKDDKGKRNQEIDDIMNKVLEKLYQEKHVLSADFIERDFEALLDKTQANSPKSSLPTTGNNNSNRPDKIKTPRPSGESMAEKEDKTPESVSAPATPVERTQMSVYTTKNTPIQSYVDMNAINDTPKKTPESMHGTTVLPRKTPTPQKNGIPSRVKFDDGLAQLIEKLRAKEQREKKHTKSTDSQWKETPGKTPNRRKGSTPATPKRSREKIDLTAKTVNSKDPLNPSKEATQGKTVTTSKDPIQSKEPA
The following text describes a protein:
Function:
Inhibitor of actin polymerization.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Translocates to nuclear foci during heat shock.
Sequence:
MAKIILRHLIETPVRYEQEFEARGLEDCRLDHALYALPGPTTVDLGKARAAQAPPVDAAEMPPQRGESRFQVLLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGIETKDLSAILCHDGILVVEVKDSAGTK
The following text describes a protein:
Function:
Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MGEKNGDAKTFWMELEDDGKVDFIFEQVQNVLQSLKQKIKDGSATNKEYIQAMILVNEATIINSSTSIKGASQKEVNAQSSDHMPVTQKEQENKSNAFPSTSCENSFPEDCTFLTTENKEILSLEDKVVDFREKDSSSNLSYQSHDCSGACLMKMPLNLKGENPLQLPIKCHFQRRHAKTNSHSSALHVSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSFNTYVQLARNYPKQKEVVSDVDISNGVESVPISFCNEIDSRKLPQFKYRKTVWPRAYNLTNFSSMFTDSCDCSEGCIDITKCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYECSLLCKCNRQLCQNRVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANTEKSYGIDENGRDENTMKNIFSKKRKLEVACSDCEVEVLPLGLETHPRTAKTEKCPPKFSNNPKELTMETKYDNISRIQYHSVIRDPESKTAIFQHNGKKMEFVSSESVTPEDNDGFKPPREHLNSKTKGAQKDSSSNHVDEFEDNLLIESDVIDITKYREETPPRSRCNQATTLDNQNIKKAIEVQIQKPQEGRSTACQRQQVFCDEELLSETKNTSSDSLTKFNKGNVFLLDATKEGNVGRFLNHSCCPNLSVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDYGYEAGTVPEKEIFCQCGVNKCRKKIL
The following text describes a protein:
Function:
Confers strong protection against cell death.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MEGSSRDLVEKFVSKKLSQNEACRKFSNNPNPMPYLMEPSTSERPGEGATQGIVEEEVLQALLEATEEFELRYQRAFSDLTSQLHITQDTAQQSFQQVMGELFRDGTNWGRIVAFFSFGRALCVESANKEMTDLLPRIVQWMVNYLEHTLQPWMQENGGWEAFVGLYGKNAAAQSRESQERFGRLLTIVMLTGVFALVCYMRRR
The following text describes a protein:
Function:
Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.
Subcellular Localization:
Cytoplasm, Stress granule. Nucleus, nucleolus.
Sequence:
MARGKRRNPSNRNQDYMPSSEPNSPTKTNMEYPNTPEKQDLVSKSYLIMMLEDFKKDLNTLREAQENINKQVKAYREESQKSLKEFQENTIKQLKELKMEIEAIKKEHMETTLDIENQKKRQGAVDTSFTNRIQEMEERISGAEDSIEIIDSTVRDNVKRKKLLVQNIQEIQDSMRRSNLRIIGIEESEDSQLKGPVNIFNKIIEENFPNLKKEIPIDIQEAYRTPNRLDQKRNTSRHIIVKTPNAQNKERILKAVREKGQVTYKGRPIRITPDFSPETMKARRSWTDVIQTLREHKCQPRLLYPAKLSINIDGETKIFHDKTKFTQYLSTNLALQRIINGKAQHKEASYTLEEARN
The following text describes a protein:
Function:
Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.
Subcellular Localization:
Cytoplasm.
Sequence:
MKLLYRKRDNDKMIIGLITEEDDDLWGVYNLLSLNDEIESYTSRKVQKDIGNNSYVTEIRKLMLTLCITKIDFDCENNSLRVSGKNVKANEYVKIGQYHTFDIGLNDKIKIMKKNWDHIHREKLEECTNIKNNCEIAILLIDCGRANMYLLTQQLYKTVFSINKIIHKKKDKNNSSSYKKSLENFFNIVLKNLYSSINFEKIKCIVLGGPGFFKNDFFSYLYEKSDMKNDKNILTLKNKFLIVKTSNIFKNSLNEILNDENMKKQILNLKVVSHVDILNKFYKIFEKNEDKICYGPDEVKYASKINAIDSLLITDKTFRSCDVKTRKEYVQVVQYVKNTGGQVYIFSDNHTSGEQLNSLTGIAAILKFPIFYDINQAHEKGQSTKEDYIKREDTQNGEHMTNI
The following text describes a protein:
Function:
Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins (By similarity). Acts redundantly with RPN5A.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEESRQLESSIDRLLNEEKQMRLAENVAGTRKAATEILKLCFEAKDWKLLNEQILNLSKKRGQLKQAVQSMVQQAMQYIDQTLDIETRIELIKTLNNVAAGKIYVEIERARLTKMLAKIKEEQGLIAEAADLMQEVAVETFGAMAKTEKIAFILEQVRLCLDQKDFVRAQILSRKINPRVFDADTTKEKKKPKEGENMVEEAPADIPTLLVLKRIYYELMIRYYSHNNEYIEICRSYKAIYDIPSVKENPEQWIPVLRKICWFLALAPHDPMQSSLLNATLEDKKLSEIPDFKMLLKQIVTMEVIQWTSLWNKYKDEFENEKNMIGGSLGDKAGEDLKLRIIEHNILVVSKYYSRITFKRLAELLCLTTEEAEKHLSEMVVSKALIAKIDRPSGIICFQIVKDSNEILNSWATNLEKLLDLVEKSCHQIHKETMVHKVALRA
The following text describes a protein:
Function:
Specific subunit of the TRAPP II complex, a highly conserved vesicle tethering complex that functions in the late Golgi as a guanine nucleotide exchange factor (GEF) for the Golgi YPT1 GTPase. TRS130 plays a role in the YPT GEF activity of TRAPP II in concert with the two other TRAPP II-specific subunits TRS65 and TRS120. Required for both the cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy through its role in ATG8 and ATG9 trafficking.
Miscellaneous:
MISCELLANEOUS: Present with 432 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus.
Sequence:
MDKEIYCGSVPVSYFDPFDLFESLRPEFQQILPLDNIHWKAFDGTVRTVNRLPIELIPEGRGEADKSNDEQPFIRFLIVNCISIDQYRAKVRPLVRQWLPNLESVSSSTGEKMIYKPIILLYANSEVVDSNLFKSVSLMEKFGKDFPHVQTLEVRSVYRSPKERQEFWNQFSQKIKASVLSIFQKRLTHLQHSLANLQKGNNFEEQLLTREKLYELYVVFNILEDASLELQKIKKEILRRNMNMPDGKLQVPFESSSKSDESLGSIIIEGTLDKFQLHKYFFIRRLRLLKLEDQTLTAFVGAFQLIKNFIESISIEYRKSVRLLEFKHYFITSMLSYFEFENVSNPLLCEIKAELLMLKRDNWVQGVMATSGYRLMDKNYPNSDVKYKFDLLKETFVDETVFQENFLTLTKEILSLFNKCEGKRQRIVDILSIEIGLLYYQGKKYEEAVSLFLSCYEYYTQTNWNSIGLKILQVFIDSLSHCPKLDVLQIDGESVSASAVLTNAFLNILKLCKDNDSKEIWWKKFMDLQMKNNIHLMYPLDGLFEVTLNSKVHLARANVSAIEVNLKSYGFPEDISTKTMRLSLKNMGGDVIVFGASDFLLKKGENKLILECRDIMYGEFSLLSFEIIVEGITFVKEFPENQDEFIVVPEIYCKESTKVLVKQAHNLNLGEYALELKSVQSDALESLQVEVEVQKNIGNMKNLPVSFSMDEIQARKRYNTPFENVRLEYYLLDQITAFDLIIKTSFTKKNDQGTFGETKKVRIQCYLQLSVSVEDIFKKDIFFFKFLLNSSVREEPVILYSSELSAPDTRNDYNIRGDYIATTPALITFDGNESFINCYEITANNNFDSKDIFNLKVRYNTLKEQLDCFITDAVLIEGDVEWFILFEKWKTFWELEILKKLKYDYDAFKENRIIRLLKTSIDLNKTKSKIRNLCIEKAVLDKILICLNKVSRGIAVCNTDMDEYVRNLVPKQLTVPVQLPGFEQFFHVQFEQMETSHDALHDTIATIGNSLSYTVIVENLSGQWGQDVIDDGGYIFEILSSNEWLIHGQKRCAIKEKRKEFEVHLIPLKKGYLNFPRVEITNINGKSCRVDHSNAFESILIF
The following text describes a protein:
Function:
Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLKTLLFIGMGSFTGGVLRYLISRYVQNFLTPSFPLGTLLVNVLGCFAIGLFYGLFERGNLMNPNLRMFLTVGFCGGFTTFSTFMNENFQLIKDDNFFYLSLYVGLSLFVGFIMLYLGYSLVKQ
The following text describes a protein:
Function:
Acyl-CoA-dependent acyltransferase involved in the synthesis of lupanine alkaloids. Can use both (-)-13alpha-hydroxymultiflorine and (+)-13alpha-hydroxylupanine as substrates. Lower activity with (-)-3beta, 13alpha-dihydroxylupanine, but no activity with (+)-epilupinine and (-)-lupinine as substrates. Tigloyl-CoA, benzoyl-CoA and, more slowly, acetyl-CoA, propionyl-CoA and 2-butenoyl-CoA can act as acyl donors.
Sequence:
MAPQTQSLVFKVRRNPQELVTPAKPTPKEFKLLSDIDDQTSLRSLTPLVTIYRNNPSMEGKDPVEIIREALSKTLVFYYPFAGRLRNGPNGKLMVDCTGEGVIFIEADADVTLDQFGIDLHPPFPCFDQLLYDVPGSDGILDSPLLLIQVTRLKCGGFIFAVRLNHAMCDAIGMSQFMKGLAEIARGEPKPFILPVWHRELLCARNPPKVTFIHNEYQKPPHDNNNNNFILQHSSFFFGPNELDAIRRLLPYHHSKSTTSDILTAFLWRCRTLALQPENPNHEFRLLYILNARYGRCSFNPPLPEGFYGNAFVSPAAISTGEKLCNNPLEYALELMKEAKSKGTEEYVHSVADLMVIKGRPSYFYNDVGYLEVSDLTKARFRDVDFGWGKAVYGGATQGYFSSILYVSYTNSKGVEGIMALTSLPTKAMERFEKELDDLFKTKDKSQILRSHI