lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MFKIVQKQTYTFLSHRYGILLIFSGIVLVIVSAFQFGEVAIEWSQDRYSRLFNIYHDNIANKAFENRMCLPIPIDAVYTWVNGSDAKLLRDLERVKRELESSTAQTPDNSTSSFHCRLKDCIAGAVMITNPFLDRLVTVNRLGVIEGSLLRINKISNITKEGGKTNSLLQFSKREEVDAVMKALQSLSLNNKNYTLSKGYITSDWTATGSVALNDRVLITGVEKDTTKEQVKLRIDQPYQEKIGEVLVENVHGLAIVFITDPDVINDLVSDAEKTNTTSTLKVSKAYLVWNMEHEESRPDEDYAPNRFEDNEELRYSLRSLEKHAPWIRRVYVVTNGQIPSWLNLDNPRLVIVSHDEIFRNQSHLPTFSSPAIESHIHRIPGLSKKFIYLNDDTMFGKDIWPDDFYTHASGQKVYLTWPVPNCAEGCPSSWIKDNYCDKACNNSECEWDGGDCTGVSAQGGAIGGIHGANTNMEQMYCNTGCANGWIADKYCDQACNVRQCGFDAGDCGKVNLPSIYSVLITASGMSVTLPKGLLVVYFNATPIFGEGSTITEGKYDNRDIVRTATIAQKFKTVHVLLYKNMSESVLTFHILGKRKDDSPLNVTFNVTVDTKENKNLEQELLALKRPDGEKEENKTRKVSEEEKEEAVFEFDDISDGRRSPKLPLAREKEVSVSFEPAEEELTEDVASQLKELTQQLQDGDITQRGHDRLRSKILAQYMLSPAYTKRRREVAQGLHQAGGKQPIIDNGLGLGIVQQPDGHGQGLGEGQGQGQLQGQVLGEGQAHGVFGGQNGQLGQGGINQQVVPQFGQAAQAGQGFRGQLENAGKQLGQGQAVFKDTDLGEIPRQQNLGQGQFKQQGQGVVGQGFGQGQVIGQQIEQGLQLGNEQLPVGQLGQVQNRGLGLGQLPLGQAPVQEGGILQGQVQGQMPVQPQGNVVFRNEARQGIFQDRLSKEQGQVVDPAQQQMQGQVPLDNAFARVQQGLDVDRGQPVLHNAGNQAFGQNLGNIGEGLGDNAGALKKEADAFDDEMFGGNKLKPGKNLNQGQAFGQGVQPGQGIHQELDNPLQPVQGQGQREAGAQIPDGNTGEIAGQGLHRGLGLGKQFGQGLDLGQAQVPLGQIPDTFGQGNQDGRPLEEQNVEEGGGMGQDNDLNNLGEDDQLGLQQGLGLKKQDPRLEETREKYKHIADKFDAQNGIKIPKDGGLPDAMVGQGHLNQPMEKENILNQPIGGQDKLNGLNQQVVFDAKPLAGVGQDLAPEDGLPLGKQPVVEHNDMNEGFGRGIDQNQPNLNPPVGLQGANDAQPAVKIQNDFANQFQNGNNLKEGNNQQVQDQLQNKDVVDLNPGNENDFMDNNNIGNLLKEQNNLPFQLPDAAEVDFDDDQGGGGGQNPQDDAGGVQGNDRGFRKLLAITDKEKVSLDSDVTQGLLKESRDILRSKTAWVEKAKQIMMRITSGVRDHDLKKKVISTEDLSTKQQVATDHEVKKWSGSVVERPLSLQEENAIAEADALRQKAEQDRKSSFLPWERTDSFNNLTKLLERQDAMQQYSAQTGPQRRLLDTFGDSLRHVNKLFNKKFGYQARKVPAHMPHMGDVGIMNDLQAEFAEEYDITASHRLRHPRDMQHAFSYFYYLMGTPKVVNVTEVFDEFDTDGSGVLSDREIRTLATRLYELPLDLKTLTSLESMIVHCADNVSSKLIAPAEDAIEKYYEEKMPQITKNLLMHCPPLIEKMQGSVKGQHMYKYEIMGEDEIAFKMIQTNVSQVIGQLDDIRKNPKKFVCLNDNIDHKSSDAYMVKAVLQDFYESLFPIPSQFELPRDYRNRFLHIDELRGWRKYRDWLRFWTHLSLGALITFSAVSFCSSRILALKRRCFGRRRWRGSGVAETIVSM
The following text describes a protein:
Function:
Transcriptional regulator. Recognizes and binds to the core DNA sequence motif 5'-GGGGG-3'. Binds to the col2a1a promoter and activates col2a1a expression. Binds to the sncgb promoter and activates sncgb expression, as part of a complex with sox9a.
Subcellular Localization:
Nucleus.
Domain:
C2H2-type zinc-finger domains 6 and 9 are important for binding to the GGGGG motif in target DNA, and for the interaction with sox9a.
Sequence:
MDSPPECMLALSCEPPLSPPSMPSLDHSPQFLPQSPQSTPSSPQTELYAPVSPCPLPEASLQDEEEEDEELSTPPSPTPAVALFPGELELGSPSSESSPPATPLAPFPSFGALEKAISSGQSTTCNDELDLQLFNNESIAVTGGTSSGPGLRFPCHVCGKRFRFQSILSLHARAHSLDRERRASAPYRTTHSKLQQNHESNSMIQNPLSGSFQKSMNEDMVPEEPLQTASSPQFLFEGTTALTPPLTEEAPISTSFSPLGHAQLEDNTPSPAAPAFRCHACKGKFRTASELARHVRILHNPYKCTMCPFSASQEERLAAHLQESHPPEDPPAEAVFPSGAIKAPPETPVPQMSVIPAFRCETCGQRFTQSWFLKGHMRKHKDSLDHKCQVCGRGFKEPWFLKNHMKVHLNKLGLKAGLGNLGPPGADQSKGPASSQVLGALYSNLLLARSMAGGGGSGSRTERSDASAGSSKSSILGYLGLPKDSSNGSCMERLQAVAQVAEMGNGGGRGGDSADGADQAAMWQLVARSLVAAQHNQQQQQQQRSHSLHQHPSSRATVAGEAKNMRAYLGGLGSREELDGSSAPWECPDCGKLFRSLQQVVAHAHVHVQKTQKGQSARGGMSREEDIINRVSGTQATGGAGQRTGENESRQEGKQLPSGVGASGSFHSVISHLSGQNGLRGSSPSSSSPRERVRGTGMKDCPYCGKAFRSSHHLKVHLRVHTGERPYKCPHCDYAGTQSGSLKYHLQRHHREQRNAMATSPNSPSPSLPSLTGSPREGAKKRRLPSMSQQSSFGRVPGEAPSSRHTQSWTIGLSEKKEGSSASAHHREGDLESQYRGLSGMMGALLPSGLEQSWIGEVTLPKVPKVSRRKPQITSRMVSANGFQDKMTSQEGGFEPLDLSRRPLQDEGGVSQSGSGPSSGSKGGNDILNQCVFCPFRTSSVELMAMHLQVNHTSKSRRKRGAPISSNNHSQKLARPDRDPLALWKFLGVEDGVASPEDWVSARAENGVSPENRETEDNLELASGAMGSFRSRKKKPQMSEHVDEEDEEIDEEENDLEANGSFANVPQNQSRRAQSVSSDLPDDDLPKEEEGVLGE
The following text describes a protein:
Function:
Key regulator for male fertility expressed transiently in round spermatids where it recruits IZUMO1 at the endoplasmic reticulum (ER) membrane and coordinates the oolemmal binding multimeric complex (IZUMO1 complex) assembly. Upon complete assembly of the IZUMO1 complex, its ER retention is released, facilitating IZUMO1 complex export to the acrosome. Through the interaction with SPPL2C, inhibits its intramembrane protease activity directly accessing the catalytic center of an I-CLiP.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MVRTMPGALYPRAGLSLFLLYLVLAAVLLRPQPLRPQRSVPEEFSAPLELSQPLSGLVDDYGVRPKHPWPRGPRPLLSRAQQRKRDGPDMAEYYYNAHL
The following text describes a protein:
Function:
Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MRNRQLLSGLLLTLAFVSLQKLCYCDDQTVLYESFDEPFEGSWIVSKNGDYEGVWKHAKSEGHDDYGLLVSEKARKYGIVKELEEPLNLKDGTVVLQYEVRFQEGLECGGAYLKYLRPQDAGWTAEGFNSESPYSIMFGPDKCGATNKVHFILKHKNPKSGEYVEHHLKFPPSVPHDKLSHVYTAILKPDNEVSILVDGEEKKKANLLSGEDFEPALIPDKTIPDPEDKKPEDWDERAKIPDPSAVKPDDWDEDAPMEIEDEEAEKPEGWLDDEPEEVDDPEATKPEDWDDEEDGMWEAPKIDNPKCETAPGCGEWKRPMKKNPAYKGKWSAPLIDNPAYKGIWKPRDIPNPDYFELDRPDYEPIAAIGIEIWTMQDGILFDNMLIAKDEKVAETYRQTTWKPKFDVEKEKQKAEEEAAGSADGLKSYQANIHLFISVHDCLQKVVFDLLNKVADISFLSAYKSKITEVIEKAEEQPNLTIGVLVSIVIVFFSLFIKLIFGGKKAAATVEKKKPEVGESSKSEDETEKKEETAAPRKRQPRRDN
The following text describes a protein:
Function:
Catalyzes the transfer of sulfur from 3-mercaptopyruvate to a thiol-containing acceptor to form an intramolecular disulfide releasing hydrogen sulfide and pyruvate (Probable). May be involved in the enhancement of bacterial growth inhibition by serine.
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal region is the non-catalytic domain; the C-terminus contains the active-site cysteine residue and the CGSGVTA motif probably responsible for substrate specificity; Contains two rhodanese domains with different primary structures but with near identical secondary structure conformations suggesting a common evolutionary origin. Only the C-terminal rhodanese domain contains the catalytic cysteine residue (By similarity).
Sequence:
MSTTWFVGADWLAEHIDDPEIQIIDARMASPGQEDRNVAQEYLNGHIPGAVFFDIEALSDHTSPLPHMLPRPETFAVAMRELGVNQDKHLIVYDEGNLFSAPRAWWMLRTFGVEKVSILGGGLAGWQRDDLLLEEGAVELPEGEFNAAFNPEAVVKVTDVLLASHENTAQIIDARPAARFNAEVDEPRPGLRRGHIPGALNVPWTELVREGELKTTDELDAIFFGRGVSYDKPIIVSCGSGVTAAVVLLALATLDVPNVKLYDGAWSEWGARADLPVEPVK
The following text describes a protein:
Function:
Participates in both transcription termination and antitermination.
Subcellular Localization:
Cytoplasm.
Domain:
Contains an N-terminal region that probably interacts with RNA polymerase and a C-terminal region composed of 3 RNA binding domains, S1, KH 1 and KH 2.
Sequence:
MNIDMAALHAIEVDRGISVNELLETIKSALLTAYRHTQGHQTDARIEIDRKTGVVRVIARETDEAGNLISEWDDTPEGFGRIAATTARQVMLQRFRDAENERTYGEFSTREGEIVAGVIQRDSRANARGLVVVRIGTETKASEGVIPAAEQVPGESYEHGNRLRCYVVGVTRGAREPLITLSRTHPNLVRKLFSLEVPEIADGSVEIVAVAREAGHRSKIAVRSNVAGLNAKGACIGPMGQRVRNVMSELSGEKIDIIDYDDDPARFVANALSPAKVVSVSVIDQTARAARVVVPDFQLSLAIGKEGQNARLAARLTGWRIDIRGDAPPPPPGQPEPGVSRGMAHDR
The following text describes a protein:
Function:
Controls the expression of genes important for virulence.
Sequence:
MVIVGFPGDPVDTVILPGGAGVDAARSEPALIDWVKAVSGTARRVVTVCTGAFLAAEAGLLGRTPSDDALGLCRTFRPRISGRSGRCRPDLHAQFAEGVDRGWSHRRHRPRAGTGRRRPRHRDCPDGCPLARPVSAPTRWADPVRGSGVDATRQTDLDPPGAGGHRGRAGGAHRIGELAQRAAMSPRHFTRVFSDEVGEAPGRYVERIRTEAARRQLEETHDTVVAIAARCGFGTAETMRRSFIRRVGISPDQYRKAFA
The following text describes a protein:
Function:
May interact with a ClpP-like protease involved in degradation of denatured proteins in the chloroplast.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
DPALERRFQPVKVPEPTVDETIQILKGLRERYEIHHKLRYTDEALVAAAQLSYQYISDRFLPDKAIDLVDEAGSRVRLRHAQLPEEARELEKELRQITKEKNEAVRGQDFEKAGELRDREMDLKAQISTLIDKNKEMSKAETEAGDVGPVVTEVDIQHIVSSWTGIPVDKVSTDESDRLLKMEDTLHTRIIGQDEAVKAISRAIRRARVGLKNPNRPIASFIFSGPTGVGKSELAKALATYYFGSEEAMIRLDMSEFMERHTVSKLIGSPPGYVGYTEGGQLTEAVRRRPYTVVLFDEIEKAHPDVFNMMLQILEDGRLTDSKGRTVDFKNTLLIMTSNVGSSVIEKGGRRIGFDLDYDEKDSSYNRIKSLVTEELKQYFRPEFLNRLDEMIVFRQLTKLEVKEIADIMLKEVFERLKVKEIELQVTERFRDRVVDEGYNPSYGARPLRRAIMRLLEDSMAEKMLAREIKEGDSVIVDVDSDGKVIVLNGSSGAPPETSTPEEVVV
The following text describes a protein:
Function:
Threonine aldolase involved in threonine degradation to glycine. May play a role in the removal of L-allo-threonine.
Sequence:
MFFNGFLDFSNFLSLFFFNGWSFLETSSTCHGINSQIIWISTLNSSTMVARTVDLRSDTVTKPTETMRAAMATAEVDDDVLGADPTAFRLESEVAKITGKEAGLFVSSGTMGNLISVLVHCDIRGSEVILGDNSHIHIYENGGISTIGGVHPRPVKNNEDGTMDIDSIEVAIRDPRGELVFPTTKLICLENSHANSGGRCLSAEYTDRVGELAKKNGLKLHIDGARIFNASVALGVPVQRLVQAADSVSVCLSKGLGAPVGSVIVGSKSFITKARRLRKTLGGGMRQVGFICAAAFVALKENVEKLDGDHKKAKELAEGLTQIKGLKVDVAAVETNIIYVDIVEGSKITAEKLYKNLEEHGVLVMPKGLSRMRIVLHHQISSSDVHYTLSCFQQAFTGMRQEIGSYSISTSRDVSYA
The following text describes a protein:
Function:
Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions.
Sequence:
MNVTIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIDRLGYRPNAVARGLASKKTTTVGVIIPDISNTFYAELARGIEDIATMYKYNIILSNSDQNKEKEFHLLNTMLGKQVDGIVFMGEDITDIHIEEFKKSPVPIVLAASFDEQNETPSVNIDYTQAAYDAMKHFIEQGHKRIGFVSGPFIDKAGSAKKLQGYKKALEEAGISYDENLVIDGDYTYDSGIEAFEKLWSNDEKPTAIFVSSDEMALGVIHAAQDAGLNVPTDVEVLGFDNTRLALMVRPQLSTVVQPMYDIGAVAMRLLTKYMNKEKVEDHTVILPHRIQFRDSTK
The following text describes a protein:
Function:
Catalyzes the transfer of an acyl chain from an acyl-[acyl-carrier-protein] (ACP) to a Kdo(2)-(acyl)-lipid IV(A) to form a Kdo(2)-lipid A.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MHKEKNDATGFIPVFQKTFLHPRFWGVWLGAGAIAALAYIPPKFRDPLLAGIGRLAGKFAKSARRRARINLLYCMPELPESEREHIIDQMFATAAQPLMMMAELCFRDPKKVLTRVHWHGQEILDELQQQERNVILLVPHAWSIDIPAMLLAEQGKPVAGMFHHQRNPLVDYLWNSARLHFGGRIHARESGIKPFISSVRQGFWGYYLPDEDYGPEQSEFVDFFATYKATLPAIGRLMKVCRAAIVPMFPVYNYREHRLDIYIRPPMDDLADADDAYIARRMNEEVELLVKPNPEQYTWILKLLKTRKEGETEPYVRKDL
The following text describes a protein:
Function:
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Subcellular Localization:
Cytoplasm. Cell membrane; Single-pass type II membrane protein; Extracellular side.
Sequence:
KERAMHVGRKKGQIVDTVVQEQRPSVLLELGAYCGYSAVRMARLLLPSARLLTIELNPDNAAIAQQVVDFAGLQDRVTVVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGCGRFECTHFSSYLEYSQMVDGLEKAVYKGPGSPAQP
The following text describes a protein:
Function:
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MADKPDITEVSRFDKTKLKKTETQEKNTLPSKEIEQ
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Sequence:
MDPNCSCATGVSCACAGSCKCKECKCTSCKKSECRAISRNLGLWLRLRGNPRLTVSASFWGTGISLPLLPFHSLSRLSALSSDGAGKHFSLGTQTPTVPPWFQNRAVPDKKSILWVWRLSSSQACYWGREVPGPVYCHLSLSPSSPGCCSCCPMGCAKCAQGCVCKGTSEKCSCCA
The following text describes a protein:
Function:
Acts as a guanine nucleotide exchange factor for small G protein GTPases like rap-1 and rap-2. Required in the hypodermis, especially in the seam cells, for proper formation of the cuticle.
Sequence:
MDPRKPRQDPVNDARFYESLIKPPHLRTPDDIRNVYEQLRQLDTFSNLFIGPLKALCKTARYERHPAQYILFRDGDVARSWYILLSGSVFIENQIYMPYGCFGKRTGQNHRRTHNCLLLQESEMIVIDYPTEPQSNGMSPRTPPRGIHHSGEPVHQKTPRKSAPNMSVDSIAMPPPPVPPRPLRLPQTAAKGPAPLPPRGLPRTYPLDFPVDIPTTSSSSSNTSYNDQHRSQVYLNGLSADEDTLVRVKHRREKSNSVGGQAQNGISTARRLRGRSTASSTTTEGETASNEGADSDEDEGSMPSQESSSGGFMDLRDSVRECLEKEPSERNSEDLAVLLDFMQHMSAFAALPMSIKRQLCLKMVFAVVNDAGTVVLAHNEKLDSWSVIVNGCVEVVKPSGERVEYKLGDSFGAEPTPATQIHIGEMRTMVDDCEFVLVEHRDFCSIMSTIGDHIEKDRDGLTGEVVSEVERRTVGTHCGQVLIKGKPDKLIHHLVDERDHNVDPHYVDDFLLTYRVFIRDPTTIFEKLMLWFADSIYRDKVARLVLLWVNNHFNDFETNDEMWNLLERFEGALERDGMHSQLSLLNIACSVKAKPRQVILTRRKDDKMMMRLVGGQESGNSVYVAEVFPDTSAAREGVKRADEMLEVNQQSAKYLSAKKAEDLLTGSLSLTLMLKNNVLGYKETIGKIEHNKPKNGTSRSGAGIPMVIPVHKTSITGKKSSTTSSKSGMMEKLMTILKSSKEDSMDFTDEAKISSADLRPSRSNPDITSISQYYGPVRSECPEHVLKIYRNDQTFKYLPVYKETSAQNVVQLALQEFNMTAEGSPEWSLCECTVTIDGVIKQRRLPPQMENLAERIALNSRYYLKNNSRSEPLVPDELAPELLKEAQTQLLSLNAQVVAAQLTLQDFSVFSAIEPTEFLDNLFKLDSKYGSPKLEEFEQLFNREMWWVATEICTERHVQKRAKLIKKFIKVARYCRDLRNFNSMFAIMSGLDKPAVRRLHSSWERVSSKYIRMLDEIHQLVDPSRNMSKYRQHLAEVAQEPPVVPIYPVIKKDLTFAHDGNATYSEKLINFEKLRLIAKSIRGVMKLSSAPYEIASMAERSGGVVMDALLHMNSFENSNVATMRKGMSGKQNQPRKKVYEQALMVRKVKSYLEGLHVVDNEMELDSMSYDIEPQVQTAHRGANSSSTANIRRVPSPTPSSLSSQSAGSADQSSRHRLLFNGTGSISSAGGGSKFGVESPQAVQKMLSLVQNSKVKGAPPQITSPSTSARSSLQRNMPRVTGRQATSSAQGPVQLNEETSTVTTYYQSDNGRRQRSGSEGRFDNIPPSTFYLTSDGLTVSPRQSLSVVIPTHPHGHSPTSPRCRSRSPASSGCSSFSTIASIAATSMAAAPSAFVSNPYQHHQTVRGHVIGHRPMPIVTSGSATLPNHVSPRGLPPKSRPTILPGSHTNSSSRMGTIKEATFLTSEQVSRV
The following text describes a protein:
Function:
Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MGKSSKDKRDAYYRLAKEQNWRARSAFKLIQIDEQFDLFEHENPDKVTRVVDLCAAPGSWSQVLSRVLIKGESFGRRAWIEKKRKESEALKRIDHGSESESPAEEERKDDIAQLKPRRNVKIVSIDLQPMAPLEGITTLQADITHPSTIPLLLRALDPEAYDSASSPTPSAIQQPHPVDLVISDGAPDVTGLHDLDIYVQSQLLYSALNLAVGVLRPGGKFVAKIFRGRDVDLIYAQLRTVFEKVSVAKPRSSRASSLEAFVVCEGFIPPAIHDGSVGMDALKNPLFGGATIPPPVSPDGNIGIEVPDEDTASPREPLTVSEAATVSASDINQQTQIRMLHSQSSIPSLANKPQRFAVENRWIPPFIACGDLSSWDSDASYSLPPDYVNLDPVQPPTAPPYRRALELRKEKGGAYGKTKLGAVGRA
The following text describes a protein:
Function:
Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSAKRNTKLRHAPLEHAYVDDKSVRRNKRSKQRGRMQDDESVDAPLNEKQAQVIARQAQLQQNEEDVSDSEQTGQPVDIDVPSDDEGQADDLAQPEDAYRHFEIDEHDEVALRAFMPAEPAQRRTLADIIMEKIQGKRTEVASQVSQTGPRELNPKVIEVYQGVGQVLSRYRSGKLPKAFKIIPRLKNWEEIVYITEPENWTAASMYAATRLFASNLKEKMAQRFYNLILLPRVRDDIAEYKRLNFHLYQAIKKAIFKPGAFFKGFLLPLCEAGDCTLREAVIIGGILVRKSIPVLHSSAAMLKMAEMPYSGATSIFLRVLLDKKYSLPFRVVDAVVAHFYRFNADHRQLPVLWHQCLLVFVQRYKEDITSEQKRALLDVLRSHNHYAITPEIRRELVQSKSRDREMPLEESSR
The following text describes a protein:
Function:
This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
Sequence:
MMNAKALYKKKALRDRRKLRIKSKLLGDALRPRVSVFRSNRYFYAQAIDDVKQSTITHIDGRKMGFKNTQEDAKKLGALFAEELKKAGIERAVYDRNGYLYHGVVAAFAESLRENGIAL
The following text describes a protein:
Function:
Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. Catalyzes the conversion of leukotriene C4 to leukotriene F4 via the hydrolysis of an amide bond (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MRGLLVLSVLLGAVFGKEDFVGHQVLRISVADEAQVQKVKELEDLEHLQLDFWRGPAHPGSPIDVRVPFPSIQAVKIFLESHGISYETMIEDVQSLLDEEQEQMFAFRSRARSTDTFNYATYHTLEEIYDFLDLLVAENPHLVSKIQIGNTYEGRPIYVLKFSTGGSKRPAIWIDTGIHSREWVTQASGVWFAKKITQDYGQDAAFTAILDTLDIFLEIVTNPDGFAFTHSTNRMWRKTRSHTAGSLCIGVDPNRNWDAGFGLSGASSNPCSETYHGKFANSEVEVKSIVDFVKDHGNIKAFISIHSYSQLLMYPYGYKTEPVPDQDELDQLSKAAVTALASLYGTKFNYGSIIKAIYQASGSTIDWTYSQGIKYSFTFELRDTGRYGFLLPASQIIPTAKETWLALLTIMEHTLNHPY
The following text describes a protein:
Function:
Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Domain:
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Sequence:
MAAAAIRARLDNLVTSMFTTVSPPRRHPIPCTPRPCGCSGGWLTLLVHLRLRSCHVIHLGHAGREFPATAVDGREWHCSPGLRHRDDQPLHQRHQEDPQRHRRNQPVVDYDIVDVLVRQLKGCSYIVGAKKVNLSCMQFRRFYEPRSKERCLMALALAWNEFCEVRSKFEAMMQLEEQIAAYGPN
The following text describes a protein:
Function:
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MPGANYRAGSGAGAGARRPRGARDREEDGGGLEPAAVARDLLRGTSNMSFEELLELQSQVGTKTYKQLVAGNSPKKQGSRPPIQNACVADKHRPLEMSAKIRVPFLRQVVPISKKVARDPRFDDLSGEYNPEVFDKTYQFLNDIRAKEKELVKKQLKKHRSGEEHEKLQQLLQRMEQQEMAQQERKQQQELHLALKQERRAQAQQGHRPYFLKKSEQRQLALAEKFKELKRSKKLENFLSRKRRRNAGKDRRHLPLSKE
The following text describes a protein:
Function:
Converts ribose 1-phosphate to ribose 5-phosphate. Involved in ribose salvage via the pentose phosphate pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDPILQELVDEWFKLDQDETTRNEVSQLIKAEDYATLKQIMHPRIGFGTSGLRAEIGAGFARMNCLTVIQASQGFAEYLLQTVPSAAKLGVVIGHDHRHKSNTFARLTAAVFLQKGFKTYFFDHLVHTPLVPFAVKTLGTAAGVMITASHNPAAYNGYKVYWGNGCAIIPPHDKGIAACIEKNLTPITWDKNLVENHKLADRDFAVGLLKNYWSQLHEFHSENNFSLEMKSLKFVYTPIHGVGLPFVTSALHLFGEQGDMISVPLQDSPNPDFPTVKFPNPEEEGALDLAYEQADANGISYVLATDPDADRFAFAEKINGAWRRFTGDEVGCILAYFIFQEYKNVGKPIDDFYVLSTTVSSAMVKSMAKVEGFHHVETLTGFKWLGNKALELEKQGKFIGLAYEEALGYMVGSIVRDKDGVNALITFLHLLKRLQLQNLSITEVFEQMSKKYGYYTTQNSYFLSRDTPKLRALVDALRHYDTKSGYPATLGSKKITNVRDLTTGYDSSSTDGKATLPVSKSSDNVTFELENGEVIMTIRTSGTEPKLKFYICARGHSLEDSIKNATEVKQAIKSEWFHPQQNGLEEP
The following text describes a protein:
Function:
Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monooxygenase. Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation. Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity. Additionally, may play a role in protein biosynthesis by modifying the translation machinery. Acts as a Fe(2+) and 2-oxoglutarate-dependent monooxygenase, catalyzing (S)-stereospecific hydroxylation at C-3 of 'Lys-22' of DRG1 and 'Lys-21' of DRG2 translation factors (TRAFAC), promoting their interaction with ribonucleic acids (RNA).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MAEAALEAVRSELREFPAAARELCVPLAVPYLDKPPTPLHFYRDWVCPNRPCIIRNALQHWPALQKWSLPYFRATVGSTEVSVAVTPDGYADAVRGDRFMMPAERRLPLSFVLDVLEGRAQHPGVLYVQKQCSNLPSELPQLLPDLESHVPWASEALGKMPDAVNFWLGEAAAVTSLHKDHYENLYCVVSGEKHFLFHPPSDRPFIPYELYTPATYQLTEEGTFKVVDEEAMEKVPWIPLDPLAPDLARYPSYSQAQALRCTVRAGEMLYLPALWFHHVQQSQGCIAVNFWYDMEYDLKYSYFQLLDSLTKASGLD
The following text describes a protein:
Function:
Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation; Gamma-tubulin complex is necessary for microtubule nucleation at the microtubule organizing centers (MTOCs).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center.
Sequence:
MLHELLLALVGYTGDLIIDEREHHKSLGICLSPNAPISEQRSFKLASDISFIDPSERDLIEKLITLGFYYRELDRFATKSRNLSWIRAADVSPLDRASELSNPKSGKPSVYRRAIANGLVEILSVYKSAVLQLEQKLLSETMPILATVTQALNKFFVILPPLYELILEIERDDIRGGQLLNLLHKRCHCGVPELQACIQRLLWHGHQVLYNQLSSWMIYGILQDQHGEFFIRRQEDRDVEYGSSILDTSEKLAHLSTVDTSLTDWHLGFHIFLDMLPEYIHMRVAESILFAGKAIRVLWNPSPAIQFQDALSNQQTKKGSQKFHGSAVGVPFQKEAFLDVKTIGEELLPQSVADKIETMLLDLKESSEFHKRSFECSVDSIRAIAASHLWQLVVVRADLNGHLKALKDYFLLAKGDFFQCFLEESRQLMRLPPRQSTAEADLMVPFQLAAIKTIGEEDKYFSRVSLLMPSFGITVKSSQRDLPKTKAYTDGSSETSVGGWDGIALEYSVDWPLQLFFTQEVLSKYRRIFQYLLRLKRTQMELEKSWASVMHQEHTYFAKHRKDQMNCSISQPPQQCFRPMWRVREHMAFLIRNLQFYIQVDVIESQWNVLQSHIQDSHDFTELVGFHQEYLSALISQSFLDIGSVSRILDSIMTLCLQFCWNIEHQESSQNTSELERITEEFNKKSNSLYTILRSSRLAGSQRAPFLRRFLLRMNFNSFFEATARGVLNVVRPRPSLPVLNQQ
The following text describes a protein:
Function:
Catalyzes the cleavage of L-cysteine to form 2-aminoprop-2-enoate and sulfide. The former then spontaneously hydrolyzes to pyruvate and NH(3). May be responsible for the production of sulfide required for the biosynthesis of iron-sulfur centers in this archaea. Is very specific for L-cysteine, with no activity being detected with D-cysteine, L-homocysteine, 3-mercaptopropionate (cysteine without the amino group), cysteamine (cysteine without the carboxylate), or mercaptolactate (the hydroxyl analog of cysteine).
Sequence:
MVSIMNKNELITEILKNEVVKALGCTEVGLIGYTVAKAKPEDLYSIKEIKLILDKGTFKNAFSVGVPNTNKFGILPAVVGGLLGREENKLEVFKDIKYDEKLEEFIENKLKIEVIDSDVYCKVIIKANKVYEAETKGSHSGKSLSDDLKNAYKSLTLKDFIDYIEDIPEEVIKIIKETIETNKNLSTPEVPEDFISLDLKDEILNHMLKKTVSAVYNRMIGINKPAMAIAGSGNMGLTATLPIIAYDEIKGHDEEKLTKSITLSALTTIYSAYHSSYISAMCGCVNRGGIGAVSGLSYYIFGFDRIEESIKSFTANLPGIVCDGGKIGCALKIASGVFAIYLSLFSKVPYTNGIVGKDFKECIENIGKIGKAMKPVDDEIIEILKNKK
The following text describes a protein:
Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MKKILIIVIKMIKMISKIIMLNRYHNFQCYKQLRIYKWIIVLMLIANSSILCMAGYNEKRLLHDLLDSYNILERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLVTNIWLKLEWNDMNLRWNTSEYGGVRDLRIPPHRIWKPDVLMYNSADEGFDGTYPTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDVSSFVTNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSDWVRVIFLYWLPCILRMSRPGRDLSMEYPPTPTSDSSERKAHIQDVELKERSSKSLLANVLDIDDDFRHNCRPLTPGGTLPHNPTYFRTVYSSSDDGSIGPIGTNRMPDAIAPPHTCFTSSADYELALILKEIRFITDQIRKEDEESDIAKDWKFAAMVVDRLCLIIFTFFTIVATIAVLFSAPHIIVS
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Involved in the integration of spacer DNA into the CRISPR cassette (By similarity). Acts as a ss- and dsDNA-specific endonuclease.
Sequence:
MDDISPSELKTILHSKRANLYYLQHCRVLVNGGRVEYVTDEGRHSHYWNIPIANTTSLLLGTGTSITQAAMRELARAGVLVGFCGGGGTPLFSANEVDVEVSWLTPQSEYRPTEYLQRWVGFWFDEEKRLVAARHFQRARLERIRHSWLEDRVLRDAGFAVDATALAVAVEDSARALEQAPNHEHLLTEEARLSKRLFKLAAQATRYGEFVRAKRGSGGDPANRFLDHGNYLAYGLAATATWVLGIPHGLAVLHGKTRRGGLVFDVADLIKDSLILPQAFLSAMRGDEEQDFRQACLDNLSRAQALDFMIDTLKDVAQRSTVSA
The following text describes a protein:
Function:
Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Plays a role in dendrite formation by melanocytes.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Single-pass membrane protein.
Domain:
The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds; The first C2 domain mediates Ca(2+)-dependent phospholipid binding.
Sequence:
MSGDYEDDLCRRALILVSDLCARVRDADTNDRCQEFNDRIRGYPRGPDADISVSLLSVIVTFCGIVLLGVSLFVSWKLCWVPWRDKGGSAVGGGPLRKDLGPGVGLAGLVGGGGHHLAAGLGGHPLLGGPHHHAHAAHHPPFAELLEPGSLGGSDTPEPSYLDMDSYPEAAAAAVAAGVKPSQTSPELPSEGGAGSGLLLLPPSGGGLPSAQSHQQVTSLAPTTRYPALPRPLTQQTLTSQPDPSSEERPPALPLPLPGGEEKAKLIGQIKPELYQGTGPGGRRSGGGPGSGEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLELAEQPPDRPLWRDIVEGGSEKADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAADPHGREHWAEMLANPRKPVEHWHQLVEEKTVTSFTKGSKGLSEKENSE