lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSKRKVTFVDGIEEEEDDQQKKRKLPDVMGGPGSRFKGKHSLDSDEEDDDEETSDGRSAKYDILAPEDVEGQENATLESEGGVPITPFNLNEEMEEGYFDSEGNYFLRKEEEIRDHWLDNIDWVRVKERTEPAVATDDYSDSEEGRAPLSKKVLLEGILQLLHPGETVAKGIQRLGGTGGKKTTGGHKARQRQSAAVRREKRGTKQEGDRKQEDNTESKMDEGEQESGDRSEEGKEREQDNGKQGTAQSRVMAEEPEGENKSEDRPKPLELLISLADQMVALGVYEIYQDTYEKVSYRLKTIAPPVELDMFADEVEEQTLEKAAESQLSDDVMWEYKWENKDGLELYGPFSSTQMQEWVDQGYFAEGVYCRRVSGSEGQFYNSHRIDFELYM
The following text describes a protein:
Function:
Transcription factor that binds to the promoter of target genes. Regulates fate specification and/or differentiation of multiple cell types arising from the embryonic mesodermal (M) lineage and the ABp(l/r)paa precursors. In the postembryonic M lineage, regulates cleavage orientation, cell proliferation and cell fate specification. Regulates hlh-1 expression to specify coelomocyte fate in the mesodermal (M) lineage. In AWC neurons, initiates expression of ceh-36, leading to the expression of terminal differentiation genes. Regulates ventral cephalic sheath (CEPsh) glia differentiation and expression of transcription factor hlh-17 in CEPsh glia. Promotes terminal differentiation and morphogenesis of the epithelial duct and pore cells. In the duct cell, cooperates with the EGF-Ras-ERK pathway in turning on the terminal differentiation gene lin-48.
Subcellular Localization:
Nucleus.
Sequence:
MPTSVMNLPIDMTTMSSQERLEKMSQLPKIELMEEEEEEEMKPSSDNKIKFNISELLEDDRKPTTQSSPSASSEDSTNEIEQTAFNFNFDPKMNPISALLQLQQTFLNVGNQQNMISPLTMFPFFGLPTAQLMHFKNMSNPDVNIQSDNGEEKDEKSEGKDGETRDSTGGSPLESDAEDDDDIGRGSDDEANSSDPSQNRKKKTRTVFSRSQVSQLEMMFECKRYLSSQERSNLAQKLHLTETQVKIWFQNRRNKFKRQAQTDDTNISLQMHRANVFSIPATTALTSPILTIPTTSAGVNMRNMISSPMDASATAAARFLFGFGTLQAQQNLNASAQAQNM
The following text describes a protein:
Function:
Probable GTPase-activating protein which stimulates the GTP hydrolysis rate by GYP5 of YPT1 and SEC4. Involved in ER to Golgi trafficking and polarized exocytosis.
Miscellaneous:
MISCELLANEOUS: Present with 2010 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Bud. Bud neck.
Sequence:
MNSNEDIHEERIEVPRTPHQTQPEKDSDRIALRDEISVPEGDEKAYSDEKVEMATTNASSNFGSNESAKDGESIGAFSNPHEALMQSKLREESQSKTILPSDDLSQQLETEESKVEEALKRITSPPLPPRADCIEESASALKSSLPPVLAGNKNDQAPLDRPQLPPRQVVNAETLHLKAPHGNATPSKSPTSAVGNSSSSTPPTLPPRRIEDPLDLAAQKHFLASTFKRNMLFYKSEDNSIKCDLDKNILNLKEDSKKINNNEIPEEVSSFWLKVIGDYQNILINDIETLHFQLSRGIPAAYRLVVWQLVSYAKSKSFDPIYETYLTEMAPFDVQEFENQLKMMDEVPSEYVKRISNVLKAYLLFDPECEFSTDIAYIINMILDVCEEEANAFGLLVRLMKVYGLRLLFLPSASEIDILCYKFDRLVEEFYPEIHNHMVEKGVRSSMFLPGFFTTLFQKKLPTEIQPRIGDMVFLEGIDSIMRILATLLSNSRDHLLKMGFDDMLELLKSGLLDAYIKQNDGTRGDTLLSNECMDKLLQDSMMKVAITPKTMKKYSSEYEEIHRLDNEKEVQYKSITEKNLHLQKHVRKLENDYTSLNREHVTIANELVKNRLNIESVLNENNGYKLQILDLKKKLDSEKKKQVLGVYVPNDLKKDLEETMKKNTQVMDENLKLQDRISELERLIEEIKTANKNGTLFEYSNSKNNPLGAGWSGFKKVFK
The following text describes a protein:
Function:
FMRFamide-like neuropeptides. Involved in mediating arousal from the sleep-like state called lethargus, which occurs during molting between larval and adult stages, in part by regulating touch sensitivity, and working in concert with neuropeptide pdf-1. Involved in neural modulation of systemic mitochondrial unfolded protein response; [SPREPIRF-amide]: Acts as a ligand to FMRFamide peptide receptor frpr-18 in vitro; [LRGEPIRF-amide]: Acts as a ligand to FMRFamide peptide receptor frpr-18 in vitro.
Sequence:
MQVSGILSALFLVLLAVIVSPFQFVQPKRILPIPTSRDQLLRGQLAYLKGTTVAQPAVNDNTLGIFEASAMAKRLRGEPIRFGKRSPREPIRFGKRFNPLPDYDFQ
The following text describes a protein:
Function:
Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (By similarity). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo (By similarity).
Miscellaneous:
MISCELLANEOUS: In contrast to its official gene name, it is not a regulatory subunit of protein phosphatase 1. This name was given due to its similarity with a protein that binds to protein phosphatase 1.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic (By similarity). Some fraction is nuclear.
Domain:
The ankyrin repeats and the SH3 domain are required for a specific interactions with TP53.
Sequence:
MMPMILTVFLSNNEQILTEVPITPETTCRDVVEFCKEPGEGGCHLAEVWRGSERPIPYDHMMYEHLQKWGPRREEVKFFLRHEDSPTESSEQGARQTQEQRTQRSVVNVPGEKRTENGVGNPRVELTLSELQDMAARQQQQIENQQQMLVAKEQRLHFLKQQERRQQQSVSENEKLQKLKERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLSQQLEDLKKGKLNGFQSYNGRLTGPAAVELKRLYQELQIRNQLNQEQNSKLQQQKELLNKRNMEVAMMDKRISELRERLYGKKIQLNRVNGTSSPQSPLSTSGRVAAVGPYIQVPSTGGFPLPGDPVKPQSLTIASSAAHGRSKSANDGNWPPLKQNSASVKSTQMTGDWKDSGMEGTLKQGAISSQPLPLSALGATEKLGIEIGKGPPPIPGVGKPLPPSYGTYPSSGPLGPGSTSSLERRKEGSLPRPGAGPPSRQKPAPLPPASNAPQPGSSQQIQQRISVPPSPTYPPAGPPAFPTGDGKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPPAHGTLNKSVKAVYGKPVLPSGSASPSPLPFLHGSLGTGTAQPQPPSDSAEKEPEQEGPSVPGEGSTVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGTPFYQPSPSQDFVGTLADMDNGNTNANGNLDEPFPPRPTAPLPEELAPSSDANDNELPSPEPEELICPQTTHQTAEPTEDNNNNVAPVPSTEQIPSPVAEAPSEEDQVPPAPLSPVIHPPAASASKRTNLKKPNSERTGHGLRVRFNPLALLLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKLGVMNKGTVYALWDYEAQNSDELSFHEGDAITILRRKDENETEWWWARLGDREGYVPKNLLGLYPRIKPRQRTLA
The following text describes a protein:
Function:
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
Sequence:
MITTIRNFLYDEKILPIRKVPGVEVICIGNVSVGGTGKTPAVHFFVKKLLARGRKVAVVSRGYRGKRKRDPLLVSDGMVIFATPQESGDESYLHAINLKVPVIVGADRYKACMFVKKHFDIDTIVLDDGFQHRKLYRDRDVVLIDATNPFGGGYVLPRGLLREDFKRAVKRASEFIITKSDLVNERELKRIKNYFIKKFHKEVSVAKHGISKLCDLKGNMKPLFWVKAKKLMIFSGLANPLNFEKTVISLAPAYIERLDFKDHHNFKTKDIALIRKKAEKMDADYILTTEKDLVKLPDNLNISNLYVLKIEFTMLEDNTLKDMKG
The following text describes a protein:
Function:
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (By similarity). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (By similarity). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (By similarity). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (By similarity). Within the MRN complex, NBS1 acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (By similarity). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to DNA double-strand breaks (DSBs).
Domain:
The FHA and BRCT domains specifically recognize and bind phosphorylated proteins.
Sequence:
MWILESELFDGKRLWLRPGKTYLFGRTVAEAGQLTISDKTVSRKHLTIHIDNVPEGGGRNLRSRSNVIVEDLESKKGTLVNGVQIRGQKTTLTEDVNEIKLGLCPKTLKIRWHPIVLSFSFTSKELRADPWTNLRDSLEQLDIKYSAEYEPTTTHVVSKKRNTSKGLQALINGRYIVTDSFINAIVQATEIPEGEEGASSALEQDFEANWPNPLDHLPPRGEEPGNHTTETYAPDARRQEVFDGYTFIFYEKKQYDNLFPAISAGKGKALLKEVVPNRTRVDEFVRYVKSVAGEKGLGSFEDGSEGKGVVVVRYTPKGEDSAWYAEFFTKFAQQLDHRPIDQKEFLEAILACDASMLRRPLEAMSQPVSVSASVEPQSSEKVRPAVEDRKEVEQSAPKQLQPSAEVPATEESAPAPHRRERRTGRSRFKGFDFDDDDIIIETPQAQSSTQVPALPQVPSASQDSLFVSQREPSLAPSEPMLEEEAPCNTRTTRQTHRKRVLSPLPEHDNSALLDEIAPITAAVKRRRIEAGQDPVPPLPEPEPEREDEDVEMVEESPPRKGKKGAATTAKGKGKKIKQEDEENVLELARRRREEAEAAAAAERQRLAQLGDDDIDYAAIRRLHIIEEIEVRQPEPHGPNRTREQDIADGRWDPRWNGRKNFKRFRRQGETGVRMPVQSVIVPLEEVRTKEYGIGDDYWLEDEEGRVPRRPKETQTQERSTIGSVRDGSGFAAAAASGKGKEKDKENEKEVGRPGSSAAAAKQRSKPAPRRTVLTLDSSDEDEDEPSPHAPGIDTISDSEPEVVSSFPSVIPASEPSRSRAAKAAERANALRSSAHSSQSQTQQHRESQLSTGSSKIQLTLAPGSSSLSFSRSGTAAGRNENGKRPFGSFVSGESTASGRGMSVESGSVRGESASKRQKQGSSGGGSFLATRRKDDGSEEESEDDELKFRFGRRR
The following text describes a protein:
Function:
Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSFVDDFVSPNKNASSTEHSAWSRYQHGSPVIALYILVYSLVFILCVLGNLAVCWVVAKTRKLHTATFYFIFNLAIADLLVAIFCMPFTLVSHILVEYQFGDFMCRLTALIQGLSVAASIYTLTAIAADRYVIFNPLKDIHPTTIIDVYIYKAILFPHDGPMSIDTMKKVLVSIWVASLVVMVPQVFVIQVRDSSFMIQDQHVDRCVEVWPDLVYKKIYSVTVVMLIYILPLMVMSFLYVRIAKKIWFQADLQRGSGSDTVRRREFIGSVPKRRKRVIKMLIVVVTLFMVSWLPLYTCWMLDEFGNMPNWQVEIVHQYVYPFAHWLSYFNSCVNPIVYGLFNRDIRKNVDWGKFSLMTRSTITTDTRCRSRRRENHQSPAEQICACVELQMETAL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MEPGTNSFRVEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLSSYTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLEGNPTVLCQKLNHGSDHQSPSSSSYNGLVESFELGSGGHADFPKAQELRDGENEEESTKDELSSQLTEHEYLPSNSSTEHDRLSTEMASQDGEEGASDSAEFHYTRPMYSKPSIMAHKRWIHVKPERFEQACEGMDVHAPYDEHQVTESINTMQTEHSVQPSGVEEDFHIGEKKVEAEFDEQADESNYDEQVDFYGSSMEEFSGERSDGNLIGHRQEAALASGYSENIEMVTGIKEEASHLGFSATDKLYPCQCGKSFTHKSQRDRHMSMHLGLRPYGCGVCGKKFKMKHHLVGHMKIHTGIKPYECNICAKRFMWRDSFHRHVTSCTKSYEAAKAEQNTTEAN
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length.
Subcellular Localization:
Cytoplasm.
Sequence:
MLSFTLRRAMSFTTRILKVRPESIQFVNDKPQISDNETLINLEIAAKELTTTHNAIGFPTETVYGLAGSALSDESVKSIYKAKNRPADNPLIVHISSIEQLKRKLINYEIPQVYLDLISHFWPGPLTILLPITKDSPISKLVTANQDTFAVRMPNHPVARALIAMSDTPIAAPSANASTRPSPTLAEHVYHDLNGKIPLILDGGACNVGVESTVIDGLVDPPMLLRPGGVSLEDIKRVGGKLWENIVVAKKTAGKLEPVKTPGMKYRHYSPTAKVVLFVNCGDGINAIENYLTNNKVDASTTKIALLKSKHFGEDHPHFIIKRLGTTGNEISHNLFKYLREVDEEDKVELIFVEGIDETNEGLAVMNRLSKAAMEVVNGGEA
The following text describes a protein:
Function:
Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MVASLGILFSHQASRYEYRTSFLTRLFGSKKIACAVFCCIIAILALFRFNTFYHAVTPQESWPLIDHMVIRTIGQVLTASGVVMATWAIVALNFYGYGFADSFDILMEERVTSFPFNVFNNPMYLGSTLEYVGASLVAASPTGMLLSALIGAMYLIALHFEEPFTAMIYADKANQNIRKEN
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLLVARFTTSVVYRSHCEKGPGKNLPFSVEIKWWLLVRMTLYFESGFAIPFFTFRH
The following text describes a protein:
Function:
Lipid phosphatase that may mediate dephosphorylation of mitochondrial proteins (By similarity). Protein phosphatase that may mediate dephosphorylation of mitochondrial proteins (By similarity). Does not dephosphorylate Akt.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MEMSAAMFARVSFYPTLLYNVLMEKASARNWYDRIDEHVILGALPFRSQANDLIEKENMKAVVSMNEDYELTAFSNNTEKWRKLGIEFLQLATTDIFESPNQEKLFRGVEFINKFLPLKQRIGGLSSSYQPENVGSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHILLHTKQWDALRLFYTNNVETKS
The following text describes a protein:
Function:
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MKKQRLEGIGKEIMRVISKVLLEEVKNPKIKGLVSVTEVDVTEDLKFADTYFSILPPLKSDEKKYDHEEILEALNEIKGFLRKRVAEEVDIRYTPEIRVKLDNSMENAIKITKLLNDLKV
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular Localization:
Cytoplasm.
Sequence:
MAASEESKVAFVEPKREIFQPQDVAKWESSQAYHDLVEFILLLGEAVKNKKTRVELNISEPLATNKGSISKMAASEEYKVAFVEPKREIFQPQDVAKWESSQAYHDLVEFILLLGEAVKNKKTRVELNISENCLKLIEVLDTMDKWIEEIPPVEQPQRFGNKAFRDWFDKMEEVLSKFPVIQHFVFGNLMSIEPAECFNKPPQPQ
The following text describes a protein:
Function:
May play a role in promoting maturation and morphological differentiation of cerebellar neurons.
Subcellular Localization:
Cytoplasm.
Sequence:
MSGARCRTLYPFSGERHGQGLRFAAGELITLLQVPDGGWWEGEKEDGLRGWFPASYVQLLEKPGMVPPPPGEESQTVILPPGWQSYLSPQGRRYYVNTTTNETTWERPSSSPGIPASPGSHRSSLPPTVNGYHASGTPAHPPETAHMSVRKSTGDSQNLGSSSPSKKQSKENTITINCVTFPHPDTMPEQQLLKPTEWSYCDYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEDYAKNLAKLSQNSLASQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHHIADLRKQLASRYASVEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI
The following text describes a protein:
Function:
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes (By similarity). In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo (By similarity). Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection (By similarity). Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways (By similarity). Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair (By similarity). Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo (By similarity). Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology (By similarity). Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length (By similarity).
Subcellular Localization:
Nucleus. Chromosome, telomere. Note=Colocalizes with telomeric DNA in interphase cells and is located at chromosome ends during metaphase.
Sequence:
MAAKRSRAAMEEQEKTSTRSDDREQAVNRWVLQFYFHQAVAAYRAGRNRDFRQLRDVMQALLVRPLEREPAVAQMLRVMQFLSRIEEGENLDCTFDKETELTPLESAIGILQLIAKEFSVPEKKIELIHKVLKEAAVIVCIKNKEFSKALAVLKRHMEKDTGNQKKRTELQTIIREKNRAHPIIRDFSYVNFQQYMFQFLKTYVDTSEPLLVTMMKSLNSERAEEPKRSSVTPESPSRTEDQEEAYEPLRRVKHSVGTLRRAETAGGVAGAPSCPEMAKDPTGAPEHVGTVKDAVRAPCPAESTEDSQGTPRCAETARDVMGAPSPSEMTKDLLGAPKCTETARDVVRAPSPAESTKDPVGTPGHAETARDVARAPSPAETTKNLPGAPECADTVKNTVRAPSPAERRKDLVRAPKRAETARDVVRAPSPAERVKDTAGASEPMKSASYPTASQPRIAAVKSSKVFSVPVEISEQPAAAAPVHAGVSSRDLERTPFRTVTTYGISVLREAFKMLSNSPDSDALFNKLDETDLPSPQQMSPSVSHRTKRRKEEKNQGSETLDSPEIPHKSKRLFTISKMIMDQGSQCSKSSESPDSSQERVVSSAYRPVQELPDQPVSTKRSSQQRWNSSYGEERKDSWSDEDELFTDAALTETSSNNSTVYGSKKQKWTVQESEWIKDGVRKYGEGRWKTISEKYPFQNRTSVQIKDRYRTMKKLGIA
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MIRSEGMSLYQLLIPRESSYDVMSELGQIDSVMIIDHQQHLLSKPFINQVQRCDEILNKVEYLLDQLNQIGQTIDHVYDFKLMLQEFDRVLSLKQIQKHTFINQIEEYITGKYQQVQQQIDTLSRLKSKLQNTREAKQAMIYARDWLGGAYFHSKSSTALDFDEQMIKSYHQHGGMMPSQKFTHFVGVMNSKDYQIFQRTVFRITKGNFMVNQTLLSVSRSCFLLIFPTFSLQSETWRKIKKLCDVLKVDHISLPLTEEQWDQRYCDYDKDIAEIENMNKLTHQLLQSILKPLLEDENTQPSLLFIRFFLVRERTLYENLNKVKMQQSIFLANLWVRTSEIQLLENILQTIKQKNPHIPAPQIKINEIVNQQPPTYFQTNQFNKLFQLITETYGIPDYKEINPSMFSIITFPFLFGVMFGDIGHGAAILIFGILLSMNKVFSPRSEQKKLREQRIQLGLQIKRQVNSKDFNDEDLNDFNLTQIIFDLRYMLLLCGAFSLYTGFIYNEYFGLSLNIFGSCMNIQDCTYPFGLDPQYEDLSFRNSYKMKLAIIIGFSQMLLGILCSGFNYLYFKKWINLFILFPARLLFFTLFIGYMVMLIIIKWSTFYADTSQAPSIITTLVDMWMHDGQVTLKTFESADYQSQLQKLILVICILCLPFLLFAPIIADSIAMIKQKKKESARFEMIPQNINSNLSNDDFVSKQSQHQSYIDIIVEHLIETLEFVLGCISNTASYLRLWALSLAHSELAKVLFDLTLKEPIANADLLASLLGMPAFLLSTFGILLCMDSMECFLHALRLHWVEFQSKFYKGNGYNFEIFSYRKEMKKYQDKMKT
The following text describes a protein:
Function:
Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus.
Subcellular Localization:
Nucleus.
Sequence:
MAVRGANTLTPFSIQAILNKKEERGGLAAPEGRPAPGGTAASMAAAPAVCCWRLFGERDAGALGGAEDSLLASPAGTRTAAGRTAESPEGWDSDSALSEENESRRRYADARGASGAGLAGGSLSLGQPVCELAASKDLEEEAAGRSDSEMSASVSGDRSPRTEDDGVGPRGAHVSALCSGAGGGGGSGPAGVAEEEEEPAAPKPRKKRSRAAFSHAQVFELERRFNHQRYLSGPERADLAASLKLTETQVKIWFQNRRYKTKRRQMAADLLASAPAAKKVAVKVLVRDDQRQYLPGEVLRPPSLLPLQPSYYYPYYCLPGWALSTCAAAAGTQ
The following text describes a protein:
Function:
Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MISAHILSRQATRPGHRGPRFTTHSTALLVQRSLGQGLPLAHRRTTRAWESTSSSTASTGSHKESGHIETAPHESLLFFNNLFPLKLSSILIWRPWTSEDLLQRFEQSSYSFIDPIRLVKRAINTHDQVPIEVTQIIPRLKDGGAFVKFTHPSDMSAAVVESKLSELLQNNPIKPWFNPFGRVKAGLVEGVPWLEDLYRLPRSRIRVEFVAAKDDASPAELSQETLYSIFRKFGKITEITSQPTDSKVLPRFAYIDFVLVRDAIMARNCMHGFVLREQGSKNATKLRLSYEQRVKAHHIWAWFTSHPRIVIPLVAALIAAFTVAVFDPIREFFVKAHVQKYFEFTNSRLYKWFKSQTSDILAFRRRKTEDAGLNALFTHRKDLIDSIQTGLLESVDTFTVVHGPRGSGKKELILDQVLKERSNVLHIDCKPVVEARGEAGTIGRLAFEVGYRPVFSWSNNISSLVDLAVQSTTGVKANFSENLESQVVKILQTTASALKQVGLSERKKEDKDADLSEDAYLEAHPERRPVIVIDHFLHKSEEKGVIYDRIADWAAALVQSNIAHVIFLTDDASYSKPLQRSLPDRVFRSVTLGDLSPDVAKKFVISQLQTDTKFAHDGQQKDSESGDQDNDNKNQKKDSNTPAPLDPTLLKELDTCITALGGRLTDLQVLARRLKIGQSPRKAVQEIIDSTASDILRMFLLSKSSTSDRKYTTEQAWYLISHLAASPSSSIPYNSVLLSNTFASSPETALEALANAELITVKSQNGMPSEIKAGKPVYQAAFQKLASDEKVKARMDLLVLTELAKMETQKIEKVEQELVMLQGLMARRPGDVSERVEYLLEKMKGGQARLKGLEKEMGVVKGQMVKG
The following text describes a protein:
Function:
Component of the cytokinin signaling pathway involved in cotyledons, leaves, and embryos development. Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Relocalization from the cytoplasm into the nucleus is induced by cytokinins.
Sequence:
MERRTRRVKFTENRTVTNVAATPSNGSPRLVRITVTDPFATDSSSDDDDNNNVTVVPRVKRYVKEIRFCQGESSSSTAARKGKHKEEESVVVEDDVSTSVKPKKYRGVRQRPWGKFAAEIRDPSSRTRIWLGTFVTAEEAAIAYDRAAIHLKGPKALTNFLTPPTPTPVIDLQTVSACDYGRDSRQSLHSPTSVLRFNVNEETEHEIEAIELSPERKSTVIKEEEESSAGLVFPDPYLLPDLSLAGECFWDTEIAPDLLFLDEETKIQSTLLPNTEVSKQGENETEDFEFGLIDDFESSPWDVDHFFDHHHHSFD
The following text describes a protein:
Function:
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone.
Subcellular Localization:
Melanosome membrane; Single-pass type I membrane protein.
Sequence:
MERNMVPLAFCCLFFFLHVCRGQFPRACSTAESLLSKECCPVWSGDGSSCGQLSGRGVCQDVVLTSSATGPQFPFSGVDDRENWPTVFYNRTCQCLGNFMGYNCADCKFGFRGPNCTERRTMIRKEIFRMSSAEKSKFVAYLNLAKHTTSRDYVIVTGTYAQMNNGSNPMFADINVYDLFVWMHYYASRDVFIGEDALWRDIDFAHEAPAFVPWHRYFLLHWEHEIQKLTGDENFTIPFWDWRDAQGCDICTDELLGGVHPTTTSLLSPASFFASWQIVCSRPEEYNAQRILCNGTGEGPLFRNPGGHDRSRTPRLPTTAEVELCLSLTNYETEPMDRSANFSFRNTLEGFADPRTGIANRSQSNMHNSLHVFLNGSMSSVQGSANDPVFVLHHAFVDSIFEQWLRRHGASVDIYPEANAPIGHNRGYYMVPFIPLYTNGEFFAASRDLGYDYDYLAESGSIEDFLLPYLEQARQIWQWLVGAAVVGGLITAVIATIVGLACRRKRKFPSEETQPLLMEAEDYQPTYQSHL