lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MFMKFFIQLAAVKLVTTCAELSLSRACQSAAGVGAGATNTWPPRVLDTIYKDRLQTLYDLLLHLLIGPSNGSSDALNAAVEVGKTTNGVRPEGPEIANTKCRTDEVEAKEAQRRLTREDDPLCYTTMLRESYAVMPETAPTLGAVSFEQRWTQQQIVERVIELQFRQEVKPSHVLCSGYRKLRPSLIGSSRRRAPVGLECLYGNAAVDIVNSSSWKVLLSRVGDLVMLHILSHAAIFTPLPNDCLLQISGAPISSSVSTFRKSSLLHTGEKMLRSHSKRKPELQTSSAQLNFRGTKRSMKQVSLEGSSSCNHAAAIGETIQDAAATMESGDDPAPYSKMRISKKLQPNSNAVEKNVEKSLWPQTSCVIDKSYQAKRKAQETTVNGDIHWMARSHNPDSEFRKRRKLEVNHVDAIREAENCEECVGRTTKRSKLPVNRGEDFSEQQTLNPHPTISDGIKAEVLQFTKFRAGATRREQFNIIPISTPSKVSTNTNVFKPRDGGTNLIQLSDTPLSSGGSFLASEVCPSTVGSSHSEPKIPDTKRTKRVRLPSWKRRKLLRKGEDACSQGLEGGVQEKPPIILVEKLNTPKGGEKDSEERRQSKLHVLPSKQYVSQGSGGSGEERGMAQEAVALFTEPSKVRQTTKRETDIPSRRTGPSHMVINRASIFYSSNFSCHPGLPANHTLNKLKPDEAGADHLHAYIFGSLDGMSAGLSSDPNVSVDTPNRRSIRLLLKQLLARAKRCAYAKLLNRHCPLPQMLNSQLAESSTPFLTAATAPSETQDGSQRSQPVVDKHERENLEQHVEVEEMMKLLLGPMYQPSGTSITKPCDQLDYVSQAQLTPIPRSGEQNAGGNNKRFEAEKHGKDCADAIHTASIVATDKTLRAGLVASYADHSSVVGFLWATCRSIIPPDMLGSKRSWRALRSSIAHFVGLRRHEKFNIQLALLKLKLSSYSWLTIAPSTTVDNISKVSSSSGERSLQQKKLVLWLYWLFTSLVVPLIRSHFYVTEIENHRQNVFYYRKPVWAKLRNIALKDLTQRNYKKLSKKSVSEALDGKALGFSKVRLLPKRTGVRPIANLAAPSQGTLKFRVKPERRPTLRQLFGDLEKPSAPSNGRAMIHCNSVSSLGAAKDSSESFTDFSPQKSWQSAAIRQSHVTTYIKDSSISPNGNSASPLFRAASKETTPCKYVLPVGEVRNSRFSRKFLKSVNFSFRSVNSVLRDAYFCLKLEKDSYPEDLGSSVFGYSDIHSKVLPFILQIKASSTTVPRLYMVVCDVTKAYDSIQQEKLLEIVSEYMRSFDYNVAKYTCVTPTLASVRVSHERAPTRASEHQQFSQLVHDLATKHSHCIFTDQGFCTSVRREKILGLLEEHIKNNIVQMGKQFYKQTVGIPQGSILSSILCSLFYGHFELQRLMPHLQSRLTEKLLSSKRAGSLASACGLLLPQAEILATQTAEMDVEHMLESSFDMRSPDPSAKTLSNGYCSCSECQKSDSSSILKNSVLLRLIDDSFFISTSEAAATMFVENMHMGSEEYGCQANKRKTATSFSVQLGKRVLPKKIYTTEDGACFIRWSGLLVNCYTVEFQADYTRYSGEHIRSTLTVKRERNQGWHLVLKMCQYMRPKCHALFFDPRINSPATIRLNAFQSFLLCAMKFHAYMCCLPRVTGDNQPFLYEVICCTIRYMYGLLRHRMETVGAKAVEYFPFVELEWLAMVAFHRILKRKQSRYRMLLAALQIQLENPKYRKMTSCPHLSSATDEKRSSMFKYIKY
The following text describes a protein:
Function:
Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Also plays a role in response to carbon starvation and the control of extracellular proteases activity (By similarity).
Sequence:
MGSFLRSFRNNAGSTTPSVGAVPAKKEVPIPPMTPLEKRLLDMGSIRGDGSDKFYGMENYGNTCYCNSILQCLYYSVPFREAVINYPTRTPIESLEAALAKSLRYPNPNAHLEAEAQAEKQRAANAQRPGMPPAQPQKPEDKDSPDYKKKMALQTLPLLEAQNNATSYGMSESLFTSLKDIFESVVGSQSRIGIVRPQQFLDVLRRDHEMFRTAMHQDAHEFLNLLLNEVVANVEAEASKQPAAIEKSLPAPDHAETVDQSASSGSKTPNTTRWVHELFEGTLTSETQCLTCEKVSQRDEIFLDLSVDLEQHSSVTSCLRKFSAEEMLCERNKFHCDNCGGLQEAEKRMKIKRLPRILALHLKRFKYTEDLQRLQKLFHRVVYPYHLRLFNTTDDAEDPDRLYELYAVVVHIGGGPYHGHYVAIIKTEDRGWLLFDDELVEPVDKNYVRNFFGDKPGLACAYVLFYQETTLEAVMKEQEQENMESNLSATDTNEAALKPNGSSPSHLAHVHSASYIPSLEEHNRPNGLKRAPTAPQLSTHHEHGDPESGAFSPVTATPPVPPIPEHLSAAPIPPKSDVQGKKERAREEKERKAAEKEREKAEKLRRKEQEARAKENQRREEAELKAALEASKASKAQEDRRQSPDHGKDKLGGGLSRLKRGSKSFSQRLGKDKETRSVSSLEAPPLPIPGHPISRDGPIPEQHQQQPDPKDDPFQDSHHPNKPMMKEDEQANHKDPKHERTGHGKWRSFSLRKKSFSILS
The following text describes a protein:
Function:
Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MLKLPPRFFSVYSTLIHILASFLCSSDVRGDFPATRFDLGTLTLSSLKLLGDAHLNNGTIKLTRELSVPTSTAGKALYGKPVKFRHPETKSPASFTTYFSFSVTNLNPSSIGGGLAFVISPDEDYLGSTGGFLGLTEETGSGSGFVAVEFDTLMDVQFKDVNGNHVGLDLNAVVSAAVADLGNVDIDLKSGNAVNSWITYDGSGRVLTVYVSYSNLKPKSPILSVPLDLDRYVSDSMFVGFSGSTQGSTEIHSVDWWSFSSSFEESSESPPPMPNSPPPSSPSSSITPSLSTVRRKTADPSSSCRNKLCKKSPAAVAGVVTAGAFFLALFAGVIIWVYSKKIKYTRKSESLASEIMKSPREFTYKELKLATDCFSSSRVIGNGAFGTVYKGILQDSGEIIAIKRCSHISQGNTEFLSELSLIGTLRHRNLLRLQGYCREKGEILLIYDLMPNGSLDKALYESPTTLPWPHRRKILLGVASALAYLHQECENQIIHRDVKTSNIMLDANFNPKLGDFGLARQTEHDKSPDATAAAGTMGYLAPEYLLTGRATEKTDVFSYGAVVLEVCTGRRPITRPEPEPGLRPGLRSSLVDWVWGLYREGKLLTAVDERLSEFNPEEMSRVMMVGLACSQPDPVTRPTMRSVVQILVGEADVPEVPIAKPSSSMSFSTSELLLTLQDSVSDCNEVLAPISTTSCSSSEHDIFIVGKDRSV
The following text describes a protein:
Function:
Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.
Sequence:
MNLLYRKTKLEWRQHKEEEAKRSSSKEAAPTGPVGPGAVPGPGVRVRDIASLRRSLRMGFMTMPASQEHTPHPCRSTMAPRSLSCHSVGSMDSVGGGPGGGLTEDSSTRRPPAKPRRHPSTKLSMAGPGAETPPSKKAGSQKPAPECRESSRKVPPQKPRRSPNTQLSVSFDESCAPAPSPRGANLPLQRLSRASRITGDLDAGAQEEEPVYIEMVGDVFRGGGRSGGGLAGPPLGSGGPTPPAAADSDSEDSEAIYEEMKYPLPEEAGDGRANGPPPLTAPSPPQQTHILQPHPHPHRRPASALPSRRDGTPTKTTPCEIPPPFPNLLQHRPPLLAFPQAKSASRAPGDGVSRLPVLCHSKEPAGSTPAPQVPARERETPPLPPPPPAANLLLLGPSGRARSHSTPLPPQGSGQTRGERELPNSHSMICPKAAGVPAAHPAPAALLPGPPKDKAVSYTMVYSAVKVTTHSVLPAGPPLGVGEPKTEEISVLHGMLCASSRPPVPGKSSPHSGAMGSAAGVLHHRSCLASPHSLPDPTGGSLTPLWTYPATAAGLKRPPAYDSLKAGGVLNKGCGMGAPSPMVKIQLQEQGTDGGAFASISCAHVIASAGTPEEEEEMGAAFGAGWALQRKVLYGGRKAKEVDTEEDGARAWNGSTEGPGKVEHEDRGPVPSGIPVRSQGAEGLLARIHHDRGGSRTALPVPCQTFPACHRNGDFTGGYRLGRSASTSGVRQAALHTPRPCSQPRDALSQTHPVLPLPLPPQPARERDGKLLEVIERKRCVCKEIKARHRPDRGLCKQESMPILPSWRRVPEPRKSGTPPCRRQHTVLWDTAI
The following text describes a protein:
Function:
Component of the kinetochore which plays a role in stabilizing microtubules and so allowing accurate chromosome segregation.
Subcellular Localization:
Nucleus.
Sequence:
MVKSADLDLMNSIISESDENFSPPPFTVEEAENSINNKSSTASLESPQNGSWHPSLYGLSVPEKTHIQNSLDLYSHGNSGSQKTHNVSFSCEIRKVKSSKLSPISNMEDSEDKKEEDESSSYKNEFKSSSSASVSSNFEKTSGSDDHNSQSPVPLNEGFEYIASSGSEDKNSDEEFAVEMILDSRMKKDGSGFQYYLKWEGYDDPSDNTWNDEEDCAGCLELIDAYWESRGGKPDLSSLIRLTRSRARSSNEASYVEKDESSNSDDSISYKRRRSRNAANRITDYVDSDLSESSMKEKQSKIEKYMKSDKSSKNFKPPFQKKSWEDLVDCVKTVQQLDNGKLIAKIKWKNGYVSTHDNIIIHQKCPLKIIEYYEAHIKFT
The following text describes a protein:
Function:
Probably catalyzes the deacetylation of N-acetylcysteine (NAC) to acetate and cysteine. Is involved in a S-(2-succino)cysteine (2SC) degradation pathway that allows B.subtilis to grow on 2SC as a sole sulfur source, via its metabolization to cysteine.
Sequence:
MADKAFHTRLINMRRDLHEHPELSFQEVETTKKIRRWLEEEQIEILDVPQLKTGVIAEIKGREDGPVIAIRADIDALPIQEQTNLPFASKVDGTMHACGHDFHTASIIGTAMLLNQRRAELKGTVRFIFQPAEEIAAGARKVLEAGVLNGVSAIFGMHNKPDLPVGTIGVKEGPLMASVDRFEIVIKGKGGHAGIPNNSIDPIAAAGQIISGLQSVVSRNISSLQNAVVSITRVQAGTSWNVIPDQAEMEGTVRTFQKEARQAVPEHMRRVAEGIAAGYGAQAEFKWFPYLPSVQNDGTFLNAASEAAARLGYQTVHAEQSPGGEDFALYQEKIPGFFVWMGTNGTEEWHHPAFTLDEEALTVASQYFAELAVIVLETIK
The following text describes a protein:
Function:
Converts sphingomyelin to ceramide.
Subcellular Localization:
Secreted.
Sequence:
MKSIPIILLVLIGLLLASVYSHDILITEKGQKSLDKLDKAAATTLQHGENIQLSCDVCQIGASLLEDFIKKNASLTEIIKGLSDLCIASKEEQPEVCTGILNNYVPIIVDVLIQSDFTPSQLCGYFKICSATGSSESSSISNSFDNEYRQESFNKPTMKVNKKPQYKDLSNQEPLVKKFKGNDSIGYILQISDVHFDPDYKVGSNPNCGRPLCCRDGVGSAGPIGHYLCDIPFSTVELIFQHLATLTDQLDFIVWTGDNPPHNVWEQSQAQQELATATLAQVIQKTFPNTPVLPSLGNHEAYPADQYVLPNSQWLLDSIYTYWAPWLDADALELVKERGYYTSLIKPGLRVMSLNTLENDMINFYNLLPTYLKGPNNQSDWMINTLEQAQSNGEKVLIIGHIPCTVKSASTDGWCAMYEQVVGQFSDVIIGQLYGHTHYDQFSVFSDVATHTIPTGMNYIVPSLTTYQNHEPGYRIYQFDYSTNQIVNYYQYHANITEANETGALNFQLTYSAKELYNMDDLSPTSWTKVANQMKTNSTMFNSYFENLSSSPIKESCDQACQTKWICQIFGITSSEFDKCYGV
The following text describes a protein:
Function:
Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
Subcellular Localization:
Cytoplasm.
Sequence:
MADEERDLIEILEENNPIDTNKYTRYVRSPKCGAIATFEGTTRDTFEGKEVLELKYEAYVPMAIRCLKTLCSSARASWDIHSIAVAHCLGTVPVGETSVFVAISAVHRADALDACKFLIDELKASVPIWKKEVYTNGEVWKENKEFIERMPDLGKTSHDQAGACSGKKKVEAHERKSCCGTKVKVNDETSDSCS
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MDQRQIRKSYRSLIKRVQDSRLQLIEQENDGLQETVLAANRLFASVQAPNEASLDAILLTRTVDLASLKTKQLKIGKTKFKIENYVRQLKRALNVNEGAALESYVRNADVLDSWAKLGEMAWKCQKRACPVEFMTGPLSFRRKERQIARRTRQQRVVTSLTKPIKLKESDLSTQKQETPGIVMQIAKILKEYEPVSLFKFITNPENFSQTVENLFCVSHLVKEGKVGIREDENGLPILETRIPPSDETLSSGKVKNIQLVLNLDMAIYEDIIETFHIKKSLIPTRPPPKELEENSTSWYG
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MVNLVNMLREHWVNVLVPLGFVIGIYMDRRNDEKLTAFRNKSMLYKRELKPGEVTWK
The following text describes a protein:
Function:
Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT (By similarity). Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence. In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis. Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes. Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, lamellipodium membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein. Apical cell membrane. Note=Localizes to lipid rafts in T cells and is recruited into the immunological synapse in response to TCR stimulation. In the choroid plexus is limited to the apical membrane in epithelial cells (By similarity).
Sequence:
MARKLSVILILTFALSVTNPLHELKAAAFPQTTEKISPNWESGINVDLAISTRQYHLQQLFYRYGENNSLSVEGFRKLLQNIGIDKIKRIHIHHDHDHHSDHEHHSDHERHSDHEHHSEHEHHSDHDHHSHHNHAASGKNKRKALCPDHDSDSSGKDPRNSQGKGAHRPEHASGRRNVKDSVSASEVTSTVYNTVSEGTHFLETIETPRPGKLFPKDVSSSTPPSVTSKSRVSRLAGRKTNESVSEPRKGFMYSRNTNENPQECFNASKLLTSHGMGIQVPLNATEFNYLCPAIINQIDARSCLIHTSEKKAEIPPKTYSLQIAWVGGFIAISIISFLSLLGVILVPLMNRVFFKFLLSFLVALAVGTLSGDAFLHLLPHSHASHHHSHSHEEPAMEMKRGPLFSHLSSQNIEESAYFDSTWKGLTALGGLYFMFLVEHVLTLIKQFKDKKKKNQKKPENDDDVEIKKQLSKYESQLSTNEEKVDTDDRTEGYLRADSQEPSHFDSQQPAVLEEEEVMIAHAHPQEVYNEYVPRGCKNKCHSHFHDTLGQSDDLIHHHHDYHHILHHHHHQNHHPHSHSQRYSREELKDAGVATLAWMVIMGDGLHNFSDGLAIGAAFTEGLSSGLSTSVAVFCHELPHELGDFAVLLKAGMTVKQAVLYNALSAMLAYLGMATGIFIGHYAENVSMWIFALTAGLFMYVALVDMVPEMLHNDASDHGCSRWGYFFLQNAGMLLGFGIMLLISIFEHKIVFRINF
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEGSSYRNAVQRRNHKERSQPVGRAKLGLLEKHKDYVLRAKDHHKKRDMLKRLSEKAAMRNKDEFYFGMINSGTRNGVHQHARPTEQLDNDVVALLKTQDVGYVRSQIIAEKKRIKALVERLAPSVAGLSTEWLDDKENRRATLQRAGLLASSARSKPPKSSSSSSTATALIGAQGKKTVWLDDADAIRSYQSASASTSASASTSKASMPVQEANEGFGASWIDDLPSDSSDIQDDFGPTETPSSASTAMKKGSKHLGYLTTELASRYSRLDQLELAAEKLNLVRALMTHKGGSSRVVKATKKASLTDAVINAELTSNALALHDTDDDEQAHRAKPKVYTFTKQRKR
The following text describes a protein:
Function:
Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Early endosome. Membrane; Multi-pass membrane protein.
Sequence:
MGDTAGFDTSDNRKGFGLALASSVFIGSSFIIKKKGLKRAAADGVRAGSGGYSYLYEPLWWVGMMTMIVGEIANFAAYAFAPAILVTPLGALSIIVSATLAHFVLKEKLHVLGMLGCLLCIVGSITIVLHAPGERVMTSVTEIWDAATQPGFMLYALCVLSLVMMLKIHFVPQYGNTHVMVYIGICSLVGSLSVMSVKALGIALKLTFQGQNQLIYVQSWIFAIFVAVCVVTQMNYLNKALDTFNTAIVSPVYYVMFTALTILASVIMFKDWDGQTPSTIVTELCGFITILSGTFLLHVTKDLGDNALDSGMSKLAFAKFLPRKALI
The following text describes a protein:
Function:
An intrinsically disordered chaperone for fibril amyloid FapC that guards against fibrillation within the periplasm (By similarity). Upon overexpression of the endogenous six-gene locus (fapA-fapF), cells form large clumps during liquid growth, make large amounts of biofilm and produce amyloid fibrils.
Subcellular Localization:
Periplasm.
Sequence:
MSGSSLRIVVPALLVIVGSVPVSLPAHAADGTIVVQRQVQPRVAYRPSMVPDPHPTVVDTNVSAEVNALANGAASGNTVSRELGDADFAIVTSGSGIRSMILTGSALPGFASQPANPATVQAVGNLGTTHGAGGGAGAGLAGQINGSLKQGLAPLQMLGGGQ
The following text describes a protein:
Function:
Negative regulator of freezing tolerance that phosphorylates 14-3-3 proteins (e.g. GRF6) thus triggering their translocation from the cytosol to the nucleus in response to cold stress.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MGCSWLSCHRREATEVDGEIAAIDNVKIYKYREIRQATDDFSAENKIGEGGFGSVYKGCLKDGKLAAIKVLSAESRQGVKEFLTEINVISEIQHENLVKLYGCCVEGNHRILVYNFLENNSLDKTLLAGGYTRSGIQFDWSSRANICVGVAKGLAFLHEEVRPHIIHRDIKASNILLDKYLSPKISDFGLARLMPPNMTHVSTRVAGTIGYLAPEYAVRGQLTRKADIYSFGVLLMEIVSGRSNKNTRLPTEYQYLLERAWELYERNELVDLVDSGLNGVFDAEEACRYLKIGLLCTQDSPKLRPSMSTVVRLLTGEKDIDYKKISRPGLISDFMDLKVRGPVATKTEQVNRQNYTNPSSSSNGSSRDHSNAYSSGASSANAGNTFSSTI
The following text describes a protein:
Function:
Catalyzes the oxidative deamination of L-lysine in the presence of NAD. Can also use (S)-(2-aminoethyl)-L-cysteine as a substrate, but more slowly. Can use both NAD and NADP but the preferred substrate is NAD.
Sequence:
MKVLVLGAGLMGKEAARDLVQSQDVEAVTLADVDLAKAEQTVRQLHSKKLAAVRVDAGDPQQLAAAMKGHDVVVNALFYQFNETVAKTAIETGVHSVDLGGHIGHITDRVLELHERAQAAGVTIIPDLGVAPGMINILSGYGASQLDEVESILLYVGGIPVRPEPPLEYNHVFSLEGLLDHYTDPALIIRNGQKQEVPSLSEVEPIYFDRFGPLEAFHTSGGTSTLSRSFPNLKRLEYKTIRYRGHAEKCKLLVDLTLTRHDVEVEINGCRVKPRDVLLSVLKPLLDLKGKDDVVLLRVIVGGRKDGKETVLEYETVTFNDRENKVTAMARTTAYTISAVAQLIGRGVITKRGVYPPEQIVPGDVYMDEMKKRGVLISEKRTVHS
The following text describes a protein:
Function:
Major thyroid hormone transport protein in serum.
Subcellular Localization:
Secreted.
Sequence:
MRILFFLFFFIVGSLANNPYPDNSGHPNNNNNWNNNYRNEIYGNRENQPNTRNREMPNQVLVNSNFDFAFKFFREVSSNRGQGYHSRRKNIVFSPMCISSAFAMLALGARANTLDQILRGLDFRPSEIQEKTIHESFHDLIYMLNNAGPGLQMEMGNCLFVEKKLHPQEQFLYGLRNIYGGDIYLENFKNTVETEQHINDYVERKTHGKIARLVDGVDPITEILLISYMYLKAKWKKPFNPKYTEMQNFYIDSYNVVKVPMMFQMGMFEAGRDDERSCTVLKMPYEGHAAAYFILPDKGQLDKVARSLSCGALRAWKKILTKSSVNVYLPKCMAIGELHLKDIMYTMGVVDVFTDKADLSGITGQPRHRLSEAIHKAMMLIDERGTEAAAASSMDLVPMSTPTVLKFNMPFIAMVVEENTESILFMATIINPNEK
The following text describes a protein:
Function:
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Sequence:
MITGKTKIIGIFGDPIEHTLSPLIHNEAFSYLGLDYCYVAFNVKKDKLKEAVEAIRALNIRGVNITVPHKETVIQYIDELSDEVKNIGAVNTILNNEGILKGFNTDVNGFILSLKDEGISMKNKNFLILGAGGAAKAIVYGILKEGGKVYIYNRTPSNALAIKEKFKKFGFIEIVEMDKSVTEKIDVIVNATSLGLKKDDPMPLNPELIKPEHVYCDIVYPETPLMREAERIGCKVVGGIGMLLWQAAFAFKIWTEVEAPIEIMKKTLNKLLTKD
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MGVDVGESAIGVDAVARPIGYGPFSAAAKARLAREKAHKAVETCDSAAAAASATVMKNVSLDTNLYLRLSLAGLPHPSQLQEWAYTSPEWRLAFVRLYRTILRLHNKAVAVSLRTARRQGSEAALSAATGMRATSQTTVAGAAVAATGADNSLAEDKDDYFLRYLLTPDQQEFGNRFVQEEFARHTDADAVAASIFYASWYEYVLQLASGVTAREMTEKEKRILTDEQKETLNSLRSAFLDLRSSQRPKYMP
The following text describes a protein:
Function:
Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. Mediates ligand-dependent transcriptional activation by nuclear hormone receptors.
Subcellular Localization:
Nucleus.
Sequence:
MPVVWPTLLDLSRDECKRILRKLELEAYAGVISALRAQGDLTKEKKDLLGELSKVLSISTERHRAEVRRAVNDERLTTIAHKMNLSLYLGERPSYSMSGPNSSSEWSIEGRRLVPLMPRLVPQTAFTVTANAVANAAIQHNASLPVPAETGSKEVVVCYSYTSTTSTPTSTPVPSGSIATVKSPRPASPASNVVVLPSGSTVYVKSVSCSDEDEKPRKRRRTNSSSSSPVVLKEVPKAVVPVSKTITVPVSGSPKMSNIMQSIANSLPPHMSPVKITFTKPSTQTTNTTTQKVIIVTTSPSSTFVPNILSKSHNYAAVTKLVPTSVIASTTQKPPVVITASQSSLVSNSSSGSSSSTPSPIPNTVAVTAVVSSTPSVVMSTVAQGVSTSAIKMASTRLPSPKSLVSAPTQILAQFPKQHQQSPKQQLYQVQQQTQQQVAQPSPVSHQQQPQQSPLPPGIKPTIQIKQESGVKIITQQVQPSKILPKPVTATLPTSSNSPIMVVSSNGAIMTTKLVTTPTGTQATYTRPTVSPSIGRMAATPGAATYVKTTSGSIITVVPKSLATLGGKIISSNIVSGTTTKITTIPMTSKPNVIVVQKTTGKGTTIQGLPGKNVVTTLLNAGGEKTIQTVPTGAKPAILTATRPITKMIVTQPKGIGSTVQPAAKIIPTKIVYGQQGKTQVLIKPKPVTFQATVVSEQTRQLVTETLQQASRVAEAGNSSIQEGKEEPQNYTDSSSSSTESSQSSQDSQPVVHVIASRRQDWSEHEIAMETSPTIIYQDVSSESQSATSTIKALLELQQTTVKEKLESKPRQPTIDLSQMAVPIQMTQEKRHSPESPSIAVVESELVAEYITTERTDEGTEVAFPLLVSHRSQPQQPSQPQRTLLQHVAQSQTATQTSVVVKSIPASSPGAITHIMQQALSSHTAFTKHSEELGTEEGEVEEMDTLDPQTGLFYRSALTQSQSAKQQKLSQPPLEQTQLQVKTLQCFQTKQKQTIHLQADQLQHKLPQMPQLSIRHQKLTPLQQEQAQPKPDVQHTQHPMVAKDRQLPTLMAQPPQTVVQVLAVKTTQQLPKLQQAPNQPKIYVQPQTPQSQMSLPASSEKQTASQVEQPIITQGSSVTKITFEGRQPPTVTKITGGSSVPKLTSPVTSISPIQASEKTAVSDILKMSLMEAQIDTNVEHMIVDPPKKALATSMLTGEAGSLPSTHMVVAGMANSTPQQQKCRESCSSPSTVGSSLTTRKIDPPAVPATGQFMRIQNVGQKKAEESPAEIIIQAIPQYAIPCHSSSNVVVEPSGLLELNNFTSQQLDDEETAMEQDIDSSTEDGTEPSPSQSSAERS
The following text describes a protein:
Function:
Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation. Mediates early complex III biogenesis. Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand (By similarity). Also required for cytochrome c oxidase complex (complex IV) assembly (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass type II membrane protein.
Sequence:
MPAGVSWPRYLRMFAASVLSMFAGAQVVHHYYRPDLSIPEIPPKPGELRTELLGLKERQMDSQKQ
The following text describes a protein:
Function:
Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping (By similarity).
Subcellular Localization:
Cytoplasm, P-body. Note=Processing bodies (PB).
Domain:
The DFDF domain is unstructured by itself. It assumes a helical fold upon interaction with other proteins (By similarity).
Sequence:
MATDWLGSIVSINCGESLGVYQGRVSAVDQVSQTISLTRPFHNGVKCLVPEVTFRAGDITELKILEIPGPGDSRQCGDLQQADTGIPGVGCQVGPSQNGTGKMLKKPFSSSAPQNIPRRTDMKNQDIIISPQQQCSKSYMDRHMETLSQSKGFRRRHNSWSSSSRHPNQVTPKKSGLKNGQMKSKDDECFGDDIDEIPDTDFDFEGNLALFDKAAVFEEIETYERRSGTRSRGTPNEKPARYRHDENILESEPIVYRRIVVPQNANKEFCTDSGLVVPSVSYELHKKLLSVAEKHGLTLERRLEMTGVCASQMALSLLGGPNRLNPKNVHQRPTVALLCGPHVKGAQGISCGRHLSNHDVHVILFLPNFVKMLESITNELNLFSSTQGQQVSSVKDLPDTPVDLVINCLDCHENAFLRDQPWYKAVVDWANQNRAPVLSIDPPISEMEQGIDAKWSLALGLPLPLGERAGRVYLCDIGIPQKVFQEVGINYHSPFGCKFVIPLHST
The following text describes a protein:
Function:
Guanine nucleotide exchange factor for Rab GTPase Rab-11.1. Spatially and temporally regulates the distribution of Rab-11.1 to target membranes during embryogenesis. Plays a role in cytokinesis, probably by targeting rab-11.1 to the cleavage furrows.
Subcellular Localization:
Cytoplasmic granule. Golgi apparatus membrane. Note=Localizes to cytoplasmic granules and to Golgi apparatus membrane in growing oocytes. Co-localizes with rab-11.1 at Golgi apparatus membrane in embryos.
Sequence:
MTEGDDQLISIRKQLENLNNATDDINSYEMKLETVKKQFCETQLMFNKEMLGIPKKLAKHISKSRQFFDLKSRESEIRRCVQQAAAQFERQKTSVEMAREQVQILHNSLNNNQELDAEKQYVDVIEQQLELVKEAEGECLKAEKCHASRVRDLLQLEMALRKCLEENGSAIKKSRPYYERKEVLTRTMNSQLELMSILEHEVQERKDSYSDSMRALEQISDQIHQERSSQSSLAPSSDAESDSS
The following text describes a protein:
Function:
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
Sequence:
MRVVYSVEEVEIPKGVSVSIERTGPFDYIVKVKGPLGEVTKEFKNTPVVMSLQDGKIVMEVFKARKREYAILGTYKGILKNMFLGVTRGWRYKLKVIYTHFPMLVKVQGNQLVIENFLGRKSKITLNIPKGVKVEVKGKEDIVIEGIDRELVSTFAAAVQAATELHGDERPSPHGREGGLGVVDGIYVVGYEHIKS
The following text describes a protein:
Function:
Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I. Not required for meiosis in females in young mice, while it is required later as mice age.
Subcellular Localization:
Nucleus. Chromosome. Note=In meiotic chromosomes, localized along axial elements in early meiosis: detectable on the axial elements in leptotene, and stays on the axial/lateral elements until mid pachytene. It then disappears and is replaced with RAD21. Compared to REC8, has mutually exclusive loading sites on the chromosomes: REC8 and RAD21L form distinct cohesin-enriched domains along the axial elements.
Sequence:
MFYTHVLMSKRGPLAKIWLAAHWEKKLTKAHVFECNLEITIQKIISPKVKIALRTSGHLLLGVVRIYNRKAKYLLADCSEAFLKMKMTFRPGLVDLPKENFEAAYNTITLPEEFHDFEIYNINEIDISEPLAQNQSRPEEITLREEYSNDLLFQAGSFGDEPEILRRHSFFDDNILMNSSGLVVEHSSGSFAEEKSLFFDNGDGFGDEGAAGEMIDNLLQDESTFLEEAYLNKEVSLPPELPSSIMVEPGNSDDQCIPEDEEINEITLLSNEDEGFTLDPIDDLDIADRRRRKKRRLLVDPVKEISSKAMHRQLASFMDTLMVLDLAPPTQRLMMWKKRGGVDMLLSTATQDLINDELKMLFTKCFLSSDYKLAKLTLKESVRKEVGNQQIAEPSVMGEPNSHSELDQPQDWKDVTDESVGSFQENVNMNVNSEQDILGMISPAVEGLSSMNGSLAQENCPAELESSGSKQNTEAEKWNQRLFQTLNVLREFNKMGMQSFSLKKLCRNSDRKQAAAKFYTLLILKKHRAIELSQSVPYADIIATVGPMFYKM
The following text describes a protein:
Function:
Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.
Sequence:
MVMAEGTAVLRRNRPGTKAQDFYNWPDESFDEMDSTLAVQQYIQQNIRADCSNIDKILEPPEGQDEGVWKYEHLRQFCLELNGLAVKLQSECHPDTCTQMTATEQWIFLCAAHKTPKECPAIDYTRHTLDGAACLLNSNKYFPSRVSIKESSVAKLGSVCRRIYRIFSHAYFHHRQIFDEYENETFLCHRFTKFVMKYNLMSKDNLIVPILEEEVQNSVSGESEA