lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum. Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear. Undergoes both rapid and slow structural rearrangements in response to changes in voltage. Contains a zinc-binding site that can regulate the slow conformational transition.
Subcellular Localization:
Cell projection, dendrite. Perikaryon. Note=Present in the dendrites and soma of cerebellar granule neurons, but not in their axon; [Isoform 1]: Cell membrane; Multi-pass membrane protein; [Isoform 2]: Cell membrane; Multi-pass membrane protein.
Domain:
The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Transplantation of the transmembrane segment S4 into HVCN1, generates a functional voltage-activated proton channel; The coiled coil mediates homodimerization.
Sequence:
MALVTSFNMANPQPAIEGGISEVEIISQQVDEETKSIAPVQLVNFAYRDLPLAAVDLSTGGSQLLSNLDEEYQREGSDWLKPCCGKRAAVWQVFLLSASLNSFLVACVILVVILLTLELLIDTKLLQFSNAFQFAGVIHWISLVILSVFFSETVLRIVVLGIWDYIENKIEVFDGAVIILSLAPMVASTVANGPRSPWDAISLIIMFRIWRVKRVIDAYVLPVKLEMEMVTQQYEKAKAIQDEQLERLTQICQEQGFEIRQLRAHLAQQDLDLAAEREAALQAPHVLSQPRSRYKVVEAGTWAEETAAESIVEELRPSQEATVKDDMNSYISQYYNGPSSDSGAPEPAVCVVTTAAIDIHQPNVPSDLFSVDLPLKLSGNSTCASATSETTSHSTCGSVTRAQSASSQTLGSSTDCSTPREELLPSKPRSSPLPLLLPPQQLVAEATVQDLMSSLSKDPCPSHKALDPAPLAQPTPLGSVQTSPELEHRVSLFNQKNQEALPVLQINPVIHLQPTAGLEEKFRSLESKEPKLHTVPEA
The following text describes a protein:
Function:
Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
Subcellular Localization:
Secreted.
Sequence:
MRALIVLVLLAVLVMAATCYESHESMESHEYLNPFLNRQRANGFIRDDTGLRAVLQERIRERNKAPQERQREICEDFHLCEQYALNHGYPAAYRHYFGRRRNK
The following text describes a protein:
Function:
May participate in auxin metabolism or response. Probable transporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSFSLRKLLVPILVLVLFLDLCVESGFSQSTPARDDHVHHHGGGCSHSHDHDHDHDHDHHVKKTTAKVEMKLPEELAEEEDMRLCGFGPCLHDHDHESSSTLTGFALWLNALGCSLLVSLASLICLVLLPIMFVQGKPSKWFVDSLALFGAGAMLGDAFLHQLPHAFGGGHSHSNDHHENHDHHDHSHSDSPSHSHSIQDLSVGLSVLAGIVVFLLVEKLVRYVEENSSGSNTWGHHHHHHHAGSKKLKDEGDHNNLDQQSSSDAIVNSSEKVSGGSTDKSLRKRKTSASDATDKSDSGTEITSDGKSDKPEQVETRSSSLVFGYLNLFSDGVHNFTDGMALGSAFLIYGSVGGWSRTMFLLAHELPQEIGDFGILVRSGFTVTKALFFNFLSALVALAGTALVLVWGNEPGQSSLIEGFTAGGFIYIAVAGVLAEMNNSGKSTLKNSACHLISLILGMSVALCISLIE
The following text describes a protein:
Function:
NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MLSRFRLTLQRCVHTREKGKPLMLNPRTNKGMAFTLLERQMLGLQGLLPPKIETQDIQALRFHKNMAKMSDPLQKYIYLMGIQERNEKLFYRVLQDDIERLLPVVYTPTVGLACTQYGHIFRRPKGLFISISDRGHIRSVVNNWPENDVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIHPHKCLPVCIDVGTDNTSLLKDPFYMGLYQKRDRSPAYDDLIDEFMEAITDRYGQNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKATGKPIAEHKVLFLGAGEVLQGGDRVPKWGCFPPLSTPQPPSPPHNPPQAALGIANLIVMAMVENGVPVEDARRRIWMYDKHGLVRQGREEKVDSNQEPFAHPAPDSIPHSFEEAVTLLKPSAIIGVAGAGRLFTPSVLQKMAAINDRPIIFALSNPTAKAECTAEEAYTLTEGRCLFASGSPFDVVTLPDGRSFKAGQGNNAYIFPGVALAVILSSVRHISDRVFLEAAKALSEQLSPPDLAQGRLYPPLSHIREVSVCIAVRVMEFLYANGMAFHYPEPPEKEPYVRSKVWTSQYDSFVPDVYQWPRNAPS
The following text describes a protein:
Function:
May be involved in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MEAPCPDKIWQDAGGAFAIGYVLMGVVNIGLGFKRSPPNKRVLYTFALLRKKSPKFGGNFAIWGSLFSGFDCTLSYIRKTEDTVNPIAAGALTGGILAARSGWKHSVQAAAFGGIFIGIIEAFQHMMQKRMQAQQEEMTQQHLEERKRYEEERKQREGERKKLNENGKSKKNKQQQNGENDLD
The following text describes a protein:
Function:
Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.
Subcellular Localization:
Peroxisome.
Sequence:
DKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGQRCLPLSMDVRVPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIRVNSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASPLASYVTGAVLVADGGAWLTFPNGVKGLADFASFSAKL
The following text describes a protein:
Function:
Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement (By similarity). Essential protein plant viability. Required for chromosome segregation (e.g. sister chromatid alignment) and cell division during embryogenesis.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with chromatin.
Domain:
The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC1A or SMC1B, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 protein, forming a ring structure (By similarity).
Sequence:
MPAIQSPSGKILQLEMENFKSYKGHQLVGPFKDFTAIIGPNGSGKSNLMDAISFVLGVRTGQLRGSQLKDLIYAFDDRDKEQRGRKAFVRLVYQMDDGVELRFTRSITSAGGSEYRIDNRVVNLDEYNGKLRSLGILVKARNFLVFQGDVESIASKNPKELTGLLEEISGSEELKKEYEGLEEKKASAEEKAALIYQKKKTIGNEKKLKKAQKEEAEKHLRLQEELKALKRERFLWQLYNIENDIEKANEDVDSEKSNRKDVMRELEKFEREAGKRKVEQAKYLKEIAQREKKIAEKSSKLGKIQPELLRFKEEIARIKAKIETNRKDVDKRKKEKGKHSKEIEQMQKSIKELNKKMELFNKKRQDSSGKLPMLDSQLQDYFRLKEEAGMKTIKLRDEHEVLERQRRTDLEALRNLEENYQQLINRKNDLDEQIKRFKDRQGEIETSSSKYKNETTSLKTELRALQEKHVNAREASAKLKTRIAELEDQLSDLTAERYENERDSRLTQAVESLKRLFQGVHGRMTDLCRPNRKKYNLAVTVAMGRFMDAVVVEDENTGKDCIKYLKEQRLPPMTFIPLQSVRVKQVFERLRNLGGTAKLVFDVIQFDPELEKAVLYAVGNTLVCDELEEAKVLSWSGERFKVVTVDGILLTKAGTMTGGTSGGMEAKSNKWDDKKIEGLKKNKEDFEQQLENIGSIREMQMKESEISGKISGLEKKIQYAEIEKKSIKDKLPQLEQEERNIIEEIDRIKPELSKARTEVDKRKTEMNKLEKRMNEIVDRIYKDFSQSVGVPNIRVYEETQLKTAEKEAEERLELSNQLAKLKYQLEYEQNRDVGSRIRKIESSISSLETDLEGIQKTMSERKETAVKITNEINNWKKEMEECKQKSEEYEKEILDWKKQASQATTSITKLNRQIHSKETQIEQLISQKQEITEKCELEHITLPVLSDAMEEDDSDGPQFDFSELGRAYLQERRPSAREKVEAEFRQKIESKTSEIERTAPNLRALDQYEAIQEKEKQVSQEFEAARKEEKQVADAFNTVKQKRYELFMEAFNHIASNIDKIYKQLTKSNTHPLGGTAYLNLENEDDPFLHGIKYTTMPPTKRFRDMEQLSGGEKTVAALALLFSIHSYRPSPFFILDEVDAALDNLNVAKVAKFIRSKSCQAARDNQDAEDGNGFQSIVISLKDSFYDKAEALVGVYRDTERSCSSTMSFDLRNYQES
The following text describes a protein:
Function:
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Subcellular Localization:
Cytoplasm.
Sequence:
MTMEVPLINGTNSVVVTAYSREQYAQCMQFYSAMLRLETLTKGENETVLTNKAVSVRVKYEEDKSRDQEARERREALAAAATTHDWRGEASTVVFSTVDVAKVRQTLGLCQAYPSELAPLEVYTLDPQGNVVGFTQTKNAISTFTNVPSVVGPRHARDSMTVSSAGSSTDLRSFGLDTTAHYPSLPKKSVAGDRKAIAVMTSGGDAPGMNANVRAIVRSVIFKGCRAFTVMEGYEGLVRGGPEYIKECKWEDVRGWSTEGGTNIGTARCMAFRERSGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIQELLETGKITQAQYDRYRHLNICGTVGSIDNDMSTTDATIGAYSSLDRICQAIDYLEATAKSHSRAFVVEVMGRNCGWLALMAGIATSADYILIPEKPASSREWQDQMCDIVSTHRSRGKRTTIVIVAEGAIAADLTPITPKDVHQVLVDRLGLDTRITTLGHVQRGGSAVAFDRILATLQGVEAVNAVLESTPDTPSPLIVLNENKIMRKPLMESVALTKSVADAIQAKDFKKAMGLRDPEFVEHLNNFMAINSADHDEPKLRGEKRLNIAIVNIGAPAGGINSAVYSMANYCLSQGHKPFAIYNGWTGLARHESVRTLNWKDMLGWQSRGGSELGTNRTVPEDADIGMIAYYFQKYKFDGLVIVGGFEAFVSLHQLERARENYPAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVVKQSAASTRARVFVVDVQGGNSGYLATHAALAVGAQVSYVPEEGISLEQLSQDIETLRESFEKAHGKGKHGKLILKSTNASKVFTTAVLADVITAEAKGDFDAKSAVPGHVQQGGLPSPIDRTRGTRLAVRAIGFIEAKQDVIREARENEEAFDCADKAVSHTAAVLGITGSQLKFTSIRQLYDLETEFSKRMPKVIHWEPTRAIADHLEGRKRVTV
The following text describes a protein:
Function:
Transcription regulator that can specifically activate or repress expression of target genes.
Sequence:
MELPLGSDLARLVRVWRALIDHRLKPLELTQTHWVTLHNIHQLPPGQSQIQLAKAIGIEQPSLVRTLDQLEDKGLITRHICAHDRRAKRILLTDMADPIIQAVNDVIDQTRSEILNGITPAEVDELATIISRLEKNILALHESQS
The following text describes a protein:
Function:
Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MWYTGTISQAVAYAKMKRYIFMIYMHGSNQASKEMEKTWEEEDVQMLSKEHFVSCRFDVNSKEGKQFSQICILFFLVFKIKTIILHCLHISDPVLHVPSTYFVGQNGMPIEILAGNIQPSQFLVRANEAIQVHQQHLASIEAAGGSVNQPAGYNQTKYEEPPPAAQAGFFGLGRKPASKPEQPVDQKIKREREAAEEKRRMLMERQKAEEEAANMPMVDTGGFTTEDHTNETCKIQFRFPDGSSMNREFHSHELLEDVVAHVAQYVGPDFGPFTLATLHPRKQLTDDYYLESLESLHLVPSAVLMVLPGSSEEYEQASWKDDLRDFLWWLLTPFIVLYRLILSLIQNSNKKSKQPRRTLPAAHDAGPISNQPGNVRYRGGGMLKGLIKITPIVTNTIRIFTNSDYDHDTLIEGTED
The following text describes a protein:
Function:
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
Subcellular Localization:
Nucleus, PML body.
Sequence:
MSSSIALTHGAVQALLRGDEVSNPVLQCLSFKKVQGPNIERIKLALSDGVHSFGTVMLGTNLNHLVNDGILDANSIVRLTHYQSPKMVQNGKKVIICLSLDVVQSGNEVGERIGNPVNYAQASANDGRAVQNENLKPNQNRMPASAMQSPKPTGKMSFGGKGDAPTTPGGTQTRVMPIGSLTPYQNKWAIRARVTQKGAMREWKNARGEGKLFSFTVLDDSGDIKVTCFKEEADKFFSMVEVGKVFCIANATLKPANPQYNSTTHDYEMTLRRDTVITLSEDDDAKLVPKIQYNFKKISELGNHVNTLVDTIGILKSAEDLSSVMIRSQNREAKVRKINLVDESNAEIQVTLWGQEAEKFTSEESAVVVLKSAKVSDFGGCSMSTIGSTTVTINPDIPEAFSLKQWYETGGKSQATQVLTTGSGGGGNMAANWKTLADIKTENLGTKEKPDYITVKATVLYCKKENILYQACPNDQCNKKVVDLQNGSYRCEKCNSESPNFKYRVILNMHMADEFDSTWVTCFQDQAEILLNMTAQQLGDLKDTNEQEYEAALKSVDFKSYFFKLRVKSDKFNDEERTRVTIMNVSPMSNVDYIKKLTTDIDKLMNL
The following text describes a protein:
Function:
Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination. Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases poe and Ufd4 to mediate the ubiquitination and proteasomal degradation of rl/MAPK.
Sequence:
MSRHEGVSCDSCLKSNFNGRRYKCLICYDYDLCADCYEDGVTSTRHLVEHPMQCILTRSDIELYFGGEMLASDQPQSFTCPYCKKMGFSDATLLEHVSAEHTETSLEVVCPVCAGLPGGEPNLVTDDFAGHLTLEHRQGPRELISFLDEPSAIRHGGGVRRIPGRTLGGPRTRRSNMHFSSSSGLSALSPSGRESVDPIAELLSQLSGVRRGGPPTSQLQQLQMQMQLDRQQVTASRQIDRLPRRAHPIVSTSNSNAAMAEVISGGAGGSGGSGAVGSGSGGGSGATAPPNLRTTEWPVTASFSTSASNHSQTQSSLAANSLNAREAIGTSSSAGSNVLGISVGVGGTANGNGGAGSSGVATGAGGAGQGGGQGGAAAGESFLLAQFMQPTFTEAEWAVVESMRADRSMFVQSLMLSMLCTEALDLNASDESLAKSDNVNKGQQQQQEDAEAEAQAETLLNNNADVEQQQQQQQLQPAMVRQVNQMQQTSPEDFVCDEYRYKNKKANTTQTSGTGGLGGAGATAAPGGGASGAGTKPTADRGIERRSGRPPPGEMATGSQQPQQQQQSTANPAASQQKYKQNASAATAAGNTNQIPDTR
The following text describes a protein:
Function:
Required for peroxisome inheritance. Acts as the peroxisome-specific receptor for the myosin V motor myo2 (By similarity).
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein. Note=Localizes at the barrier septum and the cell tip.
Sequence:
MNVDTQLSRDGLYSSLRTRYKVYISMHAFAIWHRFISFLAIYLWPCIMGSVNLNLQDRENEYFFDSIQYIIYTSELLVGDHELQRSHHEEQPSLVYPSSSFSSTSKFWRYFAYLLSLQIVIDFVLYKLSSAMASLHYLKFVKIIALSYICFSSLIRICHCWTYFIRIMGLSSLNKFVNLLHDFETTSNRVYSQICELEANSAANRSRLMDFLPANDPLLFNLTEQNTLSYELSGLYEKLLPRYQLVLSRIYPYAAASNLRNLLSLYRLPNCFGKLNSFDLRKGSSTSLKRSSMYLARKENQDFDDQSTQILNHIKTAYYELTIISKQVLCCILSFPVDSFLAERSSWLIVHREVGDLSNALSVSMVRLVDILKFSVESVNRNQHNTTSKPFPRIMCKENLRSLFNELHSVMMETHESISSYIQEGDNTAMQTYAMDEYDQVGLLLKDLLSEWDFNRALLLNLQHMHRKRK
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Promotes polyubiquitination of target proteins.
Sequence:
MSSDGNVTGGGGANTVGVTNKPFFCYQCNRTVNVTISPPSSDPTCPICNEGFLEEYDNPNPNQGSGFLNPNPNSIPFHDLFLTLSDPFASLLPLLFPSSSSTTTSSSASIDPNNPSLSGPTRSGRGDPFAFDPFTFIQNHLNDLRSSGAQIEFVIQNNPSDQGFRLPANIGDYFIGPGLEQLIQQLAENDPNRYGTPPASKSAIEALPLVNITKSNLNSEFNQCAVCMDDFEEGTEAKQMPCKHLYHKDCLLPWLELHNSCPVCRHELPTDDPDYERRVRGAQGTSGGNDGDNSGQRSDGDNRTVERSFRISLPWPFQARGPGPAPGDNAETRQEDLD
The following text describes a protein:
Function:
Required for initial steps of body morphogenesis. May play a role in egg laying and yolk protein clatherin-mediated endocytosis by oocytes during oogenesis. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord.
Subcellular Localization:
Cytoplasm. Note=Enriched at cell boundaries.
Sequence:
MNANVTVDDAISNVNLLDTLAIPDDLPDIEARALPLLYRSNFDTNFEDRSAFVTGIAKYSEEATRHAQFNDMLSEGLQHAANMYTWRCCSRAVPMAKSNDQPNRTEINEMVVEVLKPEVSKLGSFMRFTLTAIQRFCEEVRRLCHSEKRRDFVSEAYLLTLGRFINMFAVLDELKNMKASIKNDFSTFRRASQFLTAMSDTQAVHDMQNLSMFLATQNKIKDDLKLQMKTIEGYEELLCDVVNICAHMYEHQLYLSPNEKHMFVKVIAFSLFLMDGDAANVAKLDQKKRLSISRLDKIFKTLEVVPLYGDMQIQPFAFVRRSSHYEPSKWPLSDKESDRCHVNIVEKVQSIRSDHESYVTQFAKINNEVAICDRPGNDSENREITSLALSGIQLLCQWSCAVVETISWKLLNPTNPKDNRECPENAEEYERATRYNYSPAEKTALIQIIAMIKGLQSMLGKTESDMSNSTRKCVYVELQAFIHHTINEPLQKAVKHKKDLLASILQSVKDSISDAGNELNRMTDVKGKKKSSAPKGDSANSSSSDIRIPRRTAAPGSTQLYMARTQLESLISDKLCGGKKILRKELDSKTIEKISVFLRKSAHWPALFRLSDSMTEAGELSQLWFREFYLEMTMGQRIQFPIEMSMPWILTDYILSCNEPSLIESALYQLDLYNDAAQYSLFNFNKQFLYDEVEAEVNLCFDQFVYKLSEMVFTHYKQLASCMLLDKRFKAEILRSGTMIRSPSAARFESLLQQRHVQLLGRSVDLNRVVSQRVNMALLKALDAAIWKFESEPLSSIVELDMLIDTNRLCHTLLSDVLHSIAPFDDLFQEANHAVNSPHGRITLHVFWELNYDFVPNFVYNGSTHRFVRARHVFRKTPAREKPPQVGQVYYWGSKSLMAAFMNICNAYSQCIGTQHLKAITRLLHYQGIAVILDELLKMTNRLLNDKIRRHVRNVFNMMPKVCKLPRSDYGSNALLQYYVHHLEAVGKYPELKSEFCQDLRELGNMIVFCQQLEVALGQEEAHDLFLAAAYTGTVPQPPARNAQEQMKQLAKLEDKYSRIHLTEIIDKISPDDGQAAIAKDAELMTKERLCCGLNAFENFLVRIKQMLAADDIWTGGYPTNGVFWIDECVEWYRVYSALQFFLCQPTRDDNEVYAEELFGDSLQWGGLTLITLLGQHRRFEVLDFCYHLHRVNKADGKDEVISGIRLAKMVERIRRFQLLNNQIFIILENQLNENNDDPNERVREFAPPVHPNYANHAARRQ
The following text describes a protein:
Function:
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Subcellular Localization:
Nucleus.
Sequence:
MAEQGPMAIAMRLRNQLQNVYKLDPLRNEEEVKIKIKDLNEHIVCYLCAGYFIDATTITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQESEDKRIKEFYQSRGLERIIQPSGEESVPDNTGLPYTSFDHSKAHFYRYDEQVSLCLERQSSSFSGKDKNKLTLQQKFVRCSVRAEVRHLRKVLCHRLNVEKHQVQMLFNNESLPDHMTMKRLWLSHWFGKAQPLVLHYTIKDKRTR
The following text describes a protein:
Function:
Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
KWRGHGLIAVCALHSVPHSPPTTYLAARTPCRRPAEMLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDREIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF
The following text describes a protein:
Function:
Transcription factor that regulates filamentous growth through repression of EFG1. Regulates the level of colonizing fungi, favoring commensalism as opposed to candidiasis.
Subcellular Localization:
Nucleus.
Sequence:
MNGIMTTSSHSNFYNQDLVGAPSSSDHIPGPSSQDQPTNNNSPQHHHQHDQSQTTHQNHPLNQPIHHHPTQQNQSESQQSRQSHHLQQQQQQQQQQQQNQHNQQNLASSSTSYEMPSIYQQFTGSYQQTRVPKNFLLENANYYTLQPGFPLVQAADYYSTPTTTSANDYQNSTINSIISPSFQMGSVSTPDTQNSSIRSKQQQQHSYQQQQPQQLSQSQHQSQVPDIFYTQGGTIGGYVTTKQQQKEFSRKTSGDQTLVPQTNSKLQQQISETSYSQQQQQQQSPPTPQKQQQQQHYQHQTTQPYGGTGFMLYSQTGGPSSSPVAGNISIPTTIATTGQPNSQFQFTYGSPQQGSSSKTNQMYLYQRQQQQQQQHQQPQSQQMSQISQLSQQIPPQGSSKNISINSTPTKSRASSITTRSGRQSRSTSISSFIPQPDYPERVIRPKVATTRWDDENTNCYQVRARNILVSRREDTNYINGTKLLNVIGMTRGKRDGILKTEKIKNVVKVGSMNLKGVWIPFDRAYEIARNEGVDSLLYPLFVKNIKQYFLTKGHKLKSEDDEQEILEEGMTRQREEVRREGRSNGVGDFHNEEEEEIVGIQEDAGPNTAENDVPGDDEEEEDDDDDDDDDEEEGEQDDEEEEDGSSTSMSSSKNSESKLLETRDVIKSIVEEGDSTTGNVSEVKYVHEYLERSPQSTAIKEEDLYYGSSHNTPLTVHKTL
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MLTKFETKSNRVKGLTFHPKRPWILASLHSGVIQLWDYRMGTLIDRFDEHEGPVRGVHFHNSQPLFVSGGDDYKIKVWNHKTHRCLFTLLGHLDYIRTVQFHHENPWIVSASDDQTIRIWNWQSRTCISVLTGHNHYVMCASFHPKEDLVVSASLDQTVRVWDIGSLKKKTVSPADDLMRFTQMNSDLFDDRQVKLWRMNETKAWEVDTLRGHMNNVSSVMFHAKQDIIVSNSEDKSIRVWDATKRTGIQTFRREHDRFWILAVHPEINLLAAGHDNGMIVFKLERERPAFALSGNSLFYTKDRFLRYYDCSTQKDSQVIPIRRPGTPSLNQSPRTLSYSPTENAVLICSDLDGGSYELYIIPKDSVGRSDVVQDAKRGTGGSAVFIARNRFAVLEKSTSQVLVKNLKNEVVKKSSLPIPTDSIFYAGTGNLLCRSEDKVVIFDLQQRLVLGELQTPFVRYVVWSNDMESVALLSKHTIIIASKKLVLQCTLHETIRVKSGAWDDNGVFIYTTLNHIKYCLPNGDSGIIRTLDVPIYITKVSGNTILCLDRDGKNRAITINATEYIFKLALLRKRYDHVMGMIKNSQLCGQAMIAYLQQKGFPEVALHFVEDERVRFNLALESGNISVAVASATEINEKEQWYRLGVEALRQGNAGIVEFAYQQTKNFERLSFLYLITGKLDKLSKLMKIAEVKNNVMGQFHNALYLGDVKERVKILENAGHLPLAYITASVHGLKDVAERLATELGENVPSLPEGKTPSLLMPPSPVMCGGDWPLLRKSSLAAEQAAAGSFDTAMRLLNRQLGIKNFAPLKSMFIDLFNGSHSYLRAFTSSPVVPLAIERGWSESSSPNVRGPPALVYDFSQQEEKLKSGYKATTSGKLTEALRLFLSILHTIPLVVVESRSEVDEVKELVSIAKEYVLGLKMELKRRQKKDDPVRQQELAAYFTHCNLQLPHLRLALFSAMGVCYKSKNLATAYNFAKRLLETNPMESQAKTARQIVQAAERNMTDTTELNYDFRNPFVICGSTYVPIYRGQKDVSCPYCTASHWRRRIWFGMLSFSSPLINSDSL
The following text describes a protein:
Function:
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
Sequence:
MTDVESTYADFIASGRTGRRNALHDILVSSPGGNSSELALKLSELDINKAEGEGDAQRNPSEQTGEAQGEAAKQES
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Sequence:
MYVWEGVSVEFPDELKGIELEMGIDEAGRGPALGPMVYSGAIAPNKYEWPKDVDDSKKLTAEQREEIFDEIKKLPVGFAVRVISAEEISAKQTALVNPPISLNTVSHHAARDLVQAFLDKGLNIKALYVDTVGIAESYQDWLQDKFPNIKVTVRAKADATYKVVGAASICAKVTRDRLLADFKFEEPGLEISHDWGSGYPSDPKTSNWLETNFDPVFGYPSVARFDWKPIKMMFENNKMTADFELPDPHILDSPFFATRGLKQFHASSK
The following text describes a protein:
Function:
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. May modulate slc51a glycosylation, membrane trafficking and stability activities (By similarity). Able to transport taurocholate, estrone sulfate, digoxin, and prostaglandin E(2), but not p-aminohippurate or S-dinitrophenyl glutathione.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
The transmembrane domain (TM) is the major site of interaction with slc51a. The extracellular-membrane interface is absolutely required for transport activity. The intracellular-membrane interface is necessary for establishing the correct membrane orientation that is essential for the heterodimer Ost-alpha/Ost-beta complex formation and transport activity at the cell membrane surface (By similarity).
Sequence:
MSGLLKYLFGCFILCLLLQGKTHMTSATISKPHETIDIEKQNMTGERNSTLAQQLSFPMEDPTNWNYAILALAFVVLFLAFLILAQNSRANRTRKMKALNGAGGRNETEADSTQKAMMQYVVEVDNLAETDQMLQSKPTYISLNQVAQTSSPKVLPKEGQILVEWKDGNIGFLYTDSKEDDV
The following text describes a protein:
Function:
Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation. Involved in the transcriptional corepression of NF-kappaB in macrophages. Plays a role as a regulator in the pro-inflammatory cascade.
Sequence:
MDASASYLAYMAAVASAQGPNPLGALTNQPAGPANMMGLDLEMTRMAQETVQETVSEEVFTTYKASVPIIPHAQPHPADIVEAGSLAAMALPPTDYPLADTIPDDVINSGKLSALQLEGVIYACTRHQMVLPNGCRAGFFIGDGAGVGKGRQISGIILDNFARGRTRHVWFSISTDLKLDAERDLRDIGCYVKVIEGCQQLDRETKVFGLPPGFKDGVIFSTYATLVSSVQKGVGASTSRQSRLDQLINWCGGQDFDGCLIFDECHKAKHFVPGKEKNSTKVALAVATIQRLLPKARVVYCSATGVTDVKNMAFMERLGLWGRGAAFNDFDQFLDAIQRRGLGVAEMLAMEMKGSGMYISRGLSFRQAEFVTVEVNLTPQQIKTYDMAAHVWNELRQALTTAVARTATNNPRMWSTFWSSHQRFFKQLCMGMKVPAIVQEAKESLEKGYCIVIGLQTTGEASLECELSKHGGQVLGFVSLCKEIYTRFVHQHFPTHIQGQEEKEDFWCKSAKDLLLGFADKMELPNSPLDEIIDQLGGPQCVAEMTGRRGRVVRKTPKSQPQYVLRDSDTTGDMDSLNIREKTSFMDGKKLVAIISDAASTGISLHADMRAANQRRRVHITLELPWSADKAVQQMGRSHRSNQSSGPLYKLVTTSLGGERRFAAAVARRLQSLGALTKGDRRAATGADLSEFNFDTPYGRTALRNMYYGICHGEMVAGVSLDSVTHGKYQFGELNSIMQDCLTQMGVIEEGGGNSVKDKDAGVVGRFLNRILGLSVERQNLIFHYFTQCLNANVSAARREGRYNEGLVDITASSVDLVGDPREVFHGVHNGTNITRHVVLSVDRGMDWDSAVQRSKNHEKEKDGFYCSRREVRGRRLYILATQKENSTHLFKVARPNTGVSSFDEEISEILSRYSHVAVDRAEHGWKQQYEEASQHCIHGPNCKNGQACTVGSRCYRVSLLCGGIVTLMALLERTVAQYQVKLQLSKVECNLRVVRVELRDGRRIVGLRYPEVLIPLAEKALEEQNLPESIIQRIKNQPTILSNGMLALPSQTTPPPLPANRATSAVIEPPCPVVRKCLSRATTPPVTIKNFFKPCSTMKRTTSASTVAASQSDSSVEAAGQSNGDATDPDQSRASQASQSSVSQASQSSAIHSTDISQSENDQSQDGESRQTKAAVPNASSTTDGDVVFLSQDSASTQGSSFDSENKLSSSQTCQDTNTIEKLSIKRPLGSSSTNRPAKRQKGQKTNSLMSMFKKSTQKDEVSKLKKQTCPICNVVMKPGTTNGELNQHIDNCLIG
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MVLMDWSDLRIFLAIAREGTLGAAARKIGQTQPTMGRRLRALETALGQTLFQRTADGFVLTDEGTAVLRHAERIEEEALALERHATGAETQLDGLLRLSSSDWFGTVMLSPVIAAFGKRHPKVTVELLTDARLYSLPRREADLVFRIKPFSEPEVISRKLLHIPYALYGKKGSKPPRAGDGSGVRVVIMNAEFADMPDAVWLKRVLPRAEIASRSNNRQAQAELCAGGSGLAVLPRPLGDRDRRLVALDIGSTPPGRDTFVGYHRDLKRLGRLRAMLDLVIERLAG