lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.
Subcellular Localization:
Nucleus.
Sequence:
MAEVDTRQEEPVSAVIEQAQAGEDATDAQTQELALTTTNTEVAAPTEKKVKKIIRRKKRPARPQIDPALVKSEPPPQTGTTFNIWYNKWSGGDREDKYLSQTHAKGRCNIALDTGYTRADGVAGSFFCLFFARGVCPKGQDCEYLHRLPTIHDIFNPNVDCFGRDKFSDYRDDMGGVGSFSRQNRTIYIGRIHVTEDIEEIVARHFAEWGQIERIRVLNTRGVAFVTYSNEANAQFAKEAMAHQSLDHNEILNVRWATADPNPMAQKREARRIEEQAAEAIRRALPAAYVAEIEGKDPEARKRRKIESSYGLEGYEAPDEVHFARGKNAVNPRGREGYELEDQQLLMLEAGEAGGWGQEQEEEAYPQEQQQSSGGILSGSTLAALQSARVAVAAKPKAPVSAGPLVAYGSDDDSD
The following text describes a protein:
Function:
Encapsidates the viral RNA genome by forming a left-handed helical nucleocapsid that protects the RNA from nucleases. RNA replication depends on the availability of soluble nucleoprotein. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. Together with the phosphoprotein, sequesters host NF-kappa-B in inclusion bodies (IBs) thereby inhibiting this host defense pathway. May also act as a modulator of the innate immune response by sequestration of host IFIH1/MDA5 and MAVS into IBs.
Subcellular Localization:
Virion. Host cytoplasm. Note=Localizes in cytoplasmic inclusion bodies.
Sequence:
MALSKVKLNDTLNKDQLLSSSKYTIQRSTGDSIDTPNYDVQKHINKLCGMLLITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGYHVKANGVDVTTHRQDINGKEMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYRHDSPDCGMIILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEMKRYKGLLPKDIANSFYEVFEKHPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAYGAGQVMLRWGVLAKSVKNIMLGHASVQAEMEQVVEVYEYAQKLGGEAGFYHILNNPKASLLSLTQFPHFSSVVLGNAAGLGIMGEYRGTPRNQDLYDAAKAYAEQLKENGVINYSVLDLTAEELEAIKHQLNPKDNDVEL
The following text describes a protein:
Function:
The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins. Palmitoylates RAS2, which is required for its proper plasma membrane localization (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MTSFFNYHEYISSNDRAQTHHPNIYVEYGQSDTKLRRCVRVPRDYSVVGDEYPYFSTHFVGEEPGAYPSEEGPTYDSRSPLKDIISYQEYNDIVGTINGYMKRAFSPWQKCQFIETVLSFLTLWIFERLFASNNERVLAQLDEYIDQLNSKNADRFILINPRKNGFLSLDFLVMVGEPNI
The following text describes a protein:
Function:
Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components (By similarity).
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MVHERWKTVGSASQLEDRPRDKPQRASCSYVLCTVLLSLAVLLAVAVTGVVLFLNHTHTPGTAPPPIVSTGTAGANSALVTVERADSSHLSLLIDPRCPDLTDSFARLEGIQASILRALSEHQAQPRLDGAPELLDALADQLPRLLTRASELQAECAGLRKGHSLLGQGLSTLQSEQGRLIQLLSESQGHMAHLVNSVSDVLEALQRERGLGRPRVKADLQRAPSRGARPRGCANGSRPRDCLDVLLSGQQDDGVYSIFPTHYPAGFQVYCDMRTDGGGWTVFQRREDGSVNFFRGWEAYREGFGKLTGEHWLGLKRIHALTTQAAYELHVDLEDFDNGTAYAHYGSFGVGLFSVDPEEDGYPLTVADYSGTAGDSLLKHSGMRFTTKDRDSDHSENNCAAFYRGAWWYRNCHTSNLNGQYLRGAHASYADGVEWSSWTGWQYSLKFSEMKIRPVREDR
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MKEQYRETDSAKKISSITFGLLSSGEMQKLSHVKIVSNSLYEQNSRKASEYGVLDLRMGASSKDKTCVTCGMNAGDCVGHFGYIDLQMPCFHVGFFKSIINILQCICKKCSRVMLSPEKRELEMKRATRPNMMYLEKKNVRKHIQLLCKKTSKCPYCGEYNGVVKKCALLKIVHNKYQHSKKTLDDKVVEFMDSFEYAVATNKEVLNLIPKTQEILNQLVVLNLFSRIPEEDIPLLLMDPRFSRPEELIITRILVPPICIRPSVVSEIKAGTTEDDITMRLFEIVQQNRNLVSLVQSGCWMSRFMEVWDFLQLQVAQLYNSELSGVPKTSQDSKKQLRGFIQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLRIDQVGVPIHMAKILTFPERVTHINRRRMQELVMNGCDVHPGANYVEKRDSKNKFFLRFKNRDTLAQELKVGDIVERHLMDGDVILFNRQPSLHRLSIQAFYAKVMPYRTLRFNECCCNPFNADFDGDEMNLHLPQTEEAKAEAIMLMGSKSNIISPRNGEPLIAAIQDFITGSYLLTQKDVFFDKAAANRLAVSILGPRDRKVVLPLPAIIKPKELWTGKQIFSLLLRPSPDSPVLINLRSKCSGKRVDDKEKQNYICCRCKEKLEKMKLQEFCRDPSICEKCHQLLQSASGTADELCVTCCKNYHRLTDSLMPDLCYSCRDYNKNCKTEERNPNDNFVVVDSSSLLAGYMEKGHLGSGSKSNIFYMILRAFGEVHAADALSRISKLASAYIMTRGFSIGIGDVTPGKALLHTKSQLLHAGYRQCDDYIKQLLDGQLQVMPGCSEEETLEGVLLKELSNIREQAADACLRELPKTNSPLIMALSGSKGSNINISQMIACVGQQSVSGKRVPHGFEDRALPYFDKHSKDPAARGFVENSFYSGLTPSEFFFHTVAGREGLVDTAVKTAETGYMQRRLVKALEDLCCQYDETVRNSIGEVVQFVYGSDGLDPMAMETKYHKSKNGKLTAKEANRAIDFGRKEYPCQDETTLTADQVMLLFSRLLEAEEFKCLRSFKLNVKNKANRCTINPETDMETDAPVVTTSNWETLERASNFGRHLRKYMDALANNLRLKRVPPGSLCEISKISRTQLERFLNTCYNKLMKAKMEPGTAVGALAAQSIGEPGTQMTLKTFHFAGVASMNITQGVPRILEIINATKNISTPIVVCPLENNTDKDVARLVKGRMERTFLGEITEYFQEVVLPDDNFILIKLELNRIKLLRLEVNVDSVKKSILLSKLKVKMQDIEIHGDSIIIVRPPRSNKSSSYYVLQKLIEGLPRVVVKGLSSVKRAVMQILDKKGPNGENSYELVVEGTNLQSIIGIPGIVGTKVMSNNIMEVKQTFGIEAARATIIEEMMKTMGSHGISLDVRHITLLADIMCNRGDVLGINRGGMAKMRESVLMLASFENTSDHLYEAAYHGQNDPVSGVSECIIMGIPMSIGTGLFKLLQKREEEMKLSRRPLLFETPDFHLLETTI
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Subcellular Localization:
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Domain:
Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
Sequence:
MSTKWEKLEGNVGVLTIEVDAKEVNNSIDAAFKKVVKTINVPGFRKGKMPRPLFEQRFGIESLYQDALDIILPKAYGEAIEEAGIFPVDHPEIDIEKFEKNANLIFTAKVTVKPEVKLGEYKGLAVEKVETTVTDEDVENELKSLQERQAELVVKEEGTVENGDTAVIDFEGFVDGEAFEGGKGENYSLAIGSGTFIPGFEEQVIGLKSGESKDVEVSFPEEYHAAELAGKPATFKVTIHEIKTKELPELNDEFAKEADEAVATLDELKAKLRTNLEEGKKHEAEHKVRDEVVELAAANAEIEIPEAMINTELDRMVREFEQRLSQQGMNLELYYQFTGTDADKLKEQMKEDAQKRVRINLVLEAIIEAENIEVTEEEVTAEVEKMAEMYGMPVDAIKQALGSVDALAEDLKVRKAVDFLVENAA
The following text describes a protein:
Function:
Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingoid base and free fatty acids at acidic pH (By similarity). C.elegans contain specific sphingoid bases, which are unique or different in structure compared to the sphingoid bases found in other animals. Two examples of these distinctive compounds are: 15-methylhexadecasphinganine and 15-methylhexadecasphing-4-enine.
Subcellular Localization:
Lysosome. Secreted.
Sequence:
MLRELSVLLLVAVCAAKHVELPAPFKDHCILDDKQNLYDPSKQFDIKWYDVNLDLPPSERWVQIATANKEHIADLIGVLINLITPWFPNAIDFVDDVFGDLAPKLAQPYRDEIFSIANATGIPLGQITMYNIFYEIFTVCTSVIAQDKDGHVFHARNLDFGLFMGWDPVLHDWQISQKLRKMIINVNWLKDGKLLYKSNNFAGYIGIYNGLKPNAFSLTADDRFQLVGGYYGILKWVFGLEADGKWMSWLARETLETKTTYLDAKEHLMNTPMLSPVYFILGGSKKDEGCIIARSLDKTALLTEMATSPHGWYLLETNYDQGTEDLYLDDRDTPGFRCMDKLTQKNVGFEGIFNVLSSRTNLNKLTTYTVLMSVETSRFETILQSCPGECYPW
The following text describes a protein:
Function:
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MARKSFPSGQIIPTDLHEEMERSYLEYAMSVIVGRALPDVRDGLKPVHRRILYAMYELGLTPDRPFRKCARVVGDVLGKYHPHGDQSVYDALVRMVQDFSSRYPLLAGHGNFGSVDNDPPAAMRYTETRLAPIAMGAMLEGISEAIVDFTGNFDNSQEEPTVVPAQLPLLLLNGCSGIAVGMATSIPPHNLGEVVDGLIGLINKPDLSDQELFKLIPGPDFPTGGHILDSEGILQAYQTGRGLIPVRGVSHIETIRGEKKRSHNRTAIVITELPFQVNKAAWIEKIASLVNDGKLDGISDLRDESDRTGMRVVIELKRDAEPNAILQKLYRMTPLQSNFGVIFLALVNNQPVQMSLRQILQEFLQFREDTLLRQYENELGENRRRLELLTGLLIGLENLDALIEILRFAADGTTAKIQLQERLGISLQQGDAILGMPMRRITGLEREKLQQEHTDLAQRIEQLETLIGDRQERLKALKKELRGLKKKFADERRTKILQGMPAKIEPLPVNQDPLPEATIPPVESQSAPEEELDSPGEPEQEQLVLENSSPPTADSAPEAKQDDLNLAVKPTPKTVKQEAQPSPEVIATHSKLVSVAEKNPLTLFTPQTPPAEAFLSINLQGEIAWHPEELTSANSFEPLDQQFSIQGRETLIVIGDHGKAFPVAIADIPPLAVTRIPLLQILPKSAQRDATTVTFQGFLPPPEQPQDLLLVSQQGRVKLLAGQELQELGPRGLSLMKLKNGDLLQFAQLVTPVNPASAQNPGKNLVIATSNGRLLRFDPAQVGLTCSSPSAQGQEAMRLRATESLVGVLMASPGDRVLLLTQAGYGKQLDLASVRLGNFGELGTTVMQFTSKADRLLTMVAANQGAQSPQSSTYDFYSNQQRLHSVQADQFQPWGKDGFGDRLVDLNEGEHLITQVAHLG
The following text describes a protein:
Function:
Orphan receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSVMPSNLSLNGTSFFAENHSIMDKPNEQRTLNVFLFCSTFIIAFTVLLGSIYSLVSLLKLQNKSTISMIVTSLSIDDLISIVPVIIFMLTQWSSDALPQPLCTTSALIYLFQGISSNLKGSLIVSYNFYSINKTETMNCSASKRRVSMVWAILSIWIVSLLICILPLCGWGKYIPTTWGCFTDHASSYILFLFIVYSLCFCLLTVLSVPLTYQLLCSDEQQLLHVNYQEISRGYITPGTPAGCSTATPCLSPVDPVDKTLKHFQNACLSSKAVFRKGVAESSGLEPRCMNNAKSRSFTVGFAQKRFSLILALTKVILWLPMMIQMVVQHITGYQSFSFETLSFLLTLLAATVTPVFVLSEHWIHLPCGCIINCRRNSYAVSSEELKTKHRGFEFNLSFQHGYGIYRISPESHHHDGDGKSTSCHNLLVCEKPYEPPRGGGGGAALAELSTTDSARPGPAGLSATDSARPGPAGFSTTDSARPSAAGVRGEAASGLGRTVEGPERRLSHEEGHKPELTDWEWCRSKSERTPRQRSGGALAIPLCAFQGTVSLQAPTGKTLSLSTYEVSTEGQKITPTSKKIEVYRSKSVGHDPNPEECPNTFADTSVKIHLEVLEICDNEEALDTVSIISNISQSSTQVRSPSLRYSRKENRFVSCDLGETASYSLFIPSNNPDSDINITIPDTVEAHRQNSKKQHMERGGYQEEIQMLNKAYRKREEDGNSN
The following text describes a protein:
Function:
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MNTIRNSICLTIITMVLCGFLFPLAITLIGQIFFYQQANGSLITYDNRIVGSKLIGQHWTETRYFHGRPSAVDYNMNPEKLYKNGVSSGGSNESNGNTELIARMKHHVKFGNSNVTIDAATSSGSGLDPHITVENALKQAPRIADARHVSTSRVADLIQHRKQRGVLTNDYVNVLELNIALDKMKD
The following text describes a protein:
Function:
Plays a role in vesicular protein sorting.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MDSAAFPSADEQQRILQDASTVIKRNAFHMRKAIEEDNMRDSLKHAAAMLGELRTSQLQPQKYYELYMLAFDQLSYLESFFADERGKGRAYSELYELVQHAGNVLPRLYLMVAVGCLYIKSHEASPRDVLKDLVEMCKGVQHPTRGLFLRAYLCQRAKGLLPDTGSEFEGPAAGSIHDALDFLMTNFIEMNKLWVRLQHQGSARDKEKRERERQQLQDLVGKNLTYLSQLDGLSFELYRDQVLPRVLDQITSCKDDLAQLYLMQALIQGFPDRFHLGTLESLLGVLPQLQPGVKVHSVMAALMDRLARYASNASASAAGGGDPRVLEELAAIDAFSKFKAAIAQIIASQPNLPAADAVEMYVALLSYAGSVHPGQLAYVDEVLAAAHAALGDRGPGLGGDARAERQLVALLSVPLAKYGVDVALGLKEYPPLTRLLRYPTHKELAVKIVQRVLEAPPPGAAGAAPSSPAGGSPAPPVSGGCVISDVSKVKMLFRFIAPLVADPDVPGEAGGAADLDDEDLDEEQVLVARLLHHLRSDDPDTHFTILSVAHDQLLAGGPRRLRTTLPSLVFCGLALHRRLVTARAGAAGGGSAAGKKAESKKEAAAAAKKKEADEKEEEEDKKDGEKEDGEEGKEDGKAEEKKEEEKKEEPAPAPTAPAAPLTPPKLTSEQLLQFLLAAIGPLYGGPAGQPVTALRLLLAAGYVASEEARLELLAYTFFEEAIALYDEALPDQRSRATGLFDIIGGLQRCRVFGSEHRDALTAAATAGCMRLVARREQCRALCAAAWLWWQVEADKAAAGAGGDKGLQPPVRDGAKVVATLQRAAKVAGQGKAQWGATGRVRDAAYLGAYVEVADAMMRLWDAEVPGIDADKVQALLDTVQADIAAGVAPDAHSARRWASTLAHIASQAAAGATPAVKERYGKLKAPPAPPAAA
The following text describes a protein:
Function:
Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues.
Subcellular Localization:
Secreted, cell wall. Secreted, extracellular space, apoplast.
Sequence:
MANAKPALVLLLVTLISFSCSGSAQETVQYVPLSSSSFKENLVAVWNEHNAGAYGDEVQLSLNKVDNVSEGVTITTTTKYYCGYFRASVRLPRGDSSGTVATLYLASPGPDHSEVDFEFLGNKTNTQPGNNEIVLQTNIFAAGVGNREQRISLWFDPTEDFHYYSVIWNHKTVSMYVDEVLIRIFQNYEDQGVPYLRSDKAMQVYMSIFDGSSWATRGGLDKIDWSHSPFNVRYKDIIIDACVVDPASIMASPCARPEADNWWNQPYFHSLPADRLAFMDQVMKDHCIYDYCIDTKRFPVPPPECTLPRR
The following text describes a protein:
Function:
Catalyzes a trans-dehydration via an enolate intermediate.
Sequence:
MPIAASLRVLLLNGPNLSLLGRREVDVYGTVTLADIERTLQLDAQDLDVELSCLQSNHEGVLIDAIHDAFGRCDGLVINPGGLTHTSVALRDAIAGVGLPTVEVHMSNVYRRESFRHHSFIAPVAVGQISGFGADSYRLGLRAIALFLRRRAEQDEGPCR
The following text describes a protein:
Function:
Electroneutral antiporter that mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenyl nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Domain:
The regulatory N-terminal domain/NTD formed of two pairs of fused calcium-binding EF-hands, binds calcium in the mitochondrial intermembrane space and regulates the antiporter activity of the transmembrane domain/TMD. In absence of calcium, the apo form of the N-terminal domain is intrinsically disordered and binds to the transmembrane domain, inhibiting the transporter activity. Binding of calcium leads to a major conformational change and abolishes the interaction with the transmembrane domain and the inhibition of the transporter activity; The C-terminal mitochondrial carrier domain/transmembrane domain/TMD bears the transmembrane transporter activity; Linker region/H9 could directly block the transport of substrates across the transporter.
Sequence:
MLEQVQKFLLSRAACEGPDPHTRYAELFHKLDVNKDGKVDIVELQEGLKAMGMAVGKGAEEKIVAAGDTNKDGHLDFGEFIRYLEEHEKKMKIAFTSLDKNKDGKIESAEIMNSLKTLGINISLEHAEKILKSMDADGTLTVDWNEWRDHFLFNPADNIQQIIRYWKHSTVLDIGDSLTIPDEFTEEEKKTGQWWKQLLAGGMAGAVSRTGTAPLDRLKVMMQVHGSKGNANIITGLKQMVKEGGIRSLWRGNGVNVIKIAPETAMKFWAYEQYKKLFTSESGKLGTAERFIAGSLAGATAQTSIYPMEVLKTRLAVGKTGQYSGMFDCAKKIMQREGVRAFYKGYIPNILGIIPYAGIDLAIYETLKTFWLQNYATDSANPGVLVLLGCGTASSTCGQLASYPLALIRTRMQAQASIEGAPQLNMGGLFRKIVAKEGFFGLYRGIAPNFLKVLPAVSISYVVYEKMKIKLGI
The following text describes a protein:
Function:
Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate; Probable chloride channel.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSGFAPQEQEYQQALLLVVALAGLGLGLSLIFIAVYLIRFCCCRTPEPSGAKSPPPGGGCVTWSCIAALLVGCAGIGIGFYGNSETSDGVSQLSSALLHANHTLSAIDHLVLETVERLGEAVRTELTTLEEVLAQRTELVAAARGARRQAEAVAQQLQGLAFWRGVPLSLLQVAEDVSFVEEYRWLAYVLLLLLELLVCLFTLLGLAKQSKWLVIVMTVMSLLVLVLSWGSMGLEAATAVGLSDFCSSPDTYILNLTQEETGLGSDILNYYFLCNQAVSNPFQQRLTLSQRALANIHSQLQGLEREAVPQFPSAQKPLLSLEETLNVTEGNFHQLVALVHCRGLHKAWKIKCRGLGLPAGPGPLPLWPPWPGSHPVSTHSHPKPHCAQACLPCKRRTRASSPFSSVPPKGSNRTARFSKQQKPLYRRIMALPCGACVRMPWKACSSCCSTPSCLRGP
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in beta-glucoside transport (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain; The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site; The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain.
Sequence:
MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQLEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVFDVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLLAMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILLSIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNYLFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAGASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAFYGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDGSQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGSVTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDLEQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS
The following text describes a protein:
Function:
May be involved in recombinational repair of damaged DNA.
Sequence:
MLGRLYIQNFFFIRDVEVEFERGLNVITGETGTGKSMTISAIEFLMGKQGDYPEGTAVELELLGEEEIILRREVKKGRSRYYVNGKGASKSTVLELLEGKISLQGQNEFINLFREDFQRKLLDTFANLNDKVKELEKVYNSLRKKEQELFEFLRKKEELIQKKDYLEFRVREVEEIGISSEEYEELKNKANLINNLEKVKKAVGESLYKLLEGENSVYEILGEIRKNLAKVESYSGKFSELIEKIANLEEEVYELYNSLKEEMPEISEEEVNEINEKLFRIQRLEEKYKKSFPEILKEVEEIKEELSNLNSVDFKEEELREEVEKLREEYDKLAEEVSRDRRKKAEDLEERIEEILKELNLERAKLKVEIKESEPTKYGKDKIEFLFSSYGKDFKPLEEVASGGELSRLFLALSLILPASETYVFDEVDAGISGETSFKVAKFLKELSKKMQVIVITHSAPLCAAGDKNFKTEKKFLGDIPYIVVRELSEEEKVEEVARLMGMKSEKTLEGAKELVEAFK
The following text describes a protein:
Function:
Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).
Subcellular Localization:
Cytoplasm.
Sequence:
MPIITVETNLSYTQFPENFGPELSKFTSETLDKPEERITISLVTDRRMWRNGSDLPMIQIHVSAIGAVSTGQQNSIHAKKFTEFIMEKTSLPIERIFLVFTPLESWQIGKNGTVAF
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Involved in germline establishment and development.
Subcellular Localization:
Nucleus. Nucleus, Cajal body. Cytoplasm, cytosol.
Sequence:
MTIGKNNKMIQHLNYRVRIVLQDSRTFIGTFKAFDKHMNLILGDCEEFRKIRSKNSKVPEREEKRVLGFVLLRGENIVSLTVEGPPPPEEGLPRVPIPGAAPGPGIGRVAGRGMPINLSAVPAGLQGPVRGVGGPAQQHMAPMGRGVPRAPMMGAPPPGMIPGGMPSMPGNMGRGAPPPMRGPPPSMIRGAPPPGRGGY
The following text describes a protein:
Function:
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for storage lipid synthesis; Upon expression in E.coli functions weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has very weak wax synthase activity, incorporating palmityl alcohol into wax esters in the presence of palmitoyl-CoA.
Sequence:
MKRLSGWDAVLLYSETPNVHMHTLKVAVIELDSDRQEFGVDAFREVIAGRLHKLEPLGYQLVDVPLKFHHPMWREHCQVDLNYHIRPWRLRAPGGRRELDEAVGEIASTPLNRDHPLWEMYFVEGLANHRIAVVAKIHHALADGVASANMMARGMDLLPGPEVGRYVPDPAPTKRQLLSAAFIDHLRHLGRIPATIRYTTQGLGRVRRSSRKLSPALTMPFTPPPTFMNHRLTPERRFATATLALIDVKATAKLLGATINDMVLAMSTGALRTLLLRYDGKAEPLLASVPVSYDFSPERISGNRFTGMLVALPADSDDPLQRVRVCHENAVSAKESHQLLGPELISRWAAYWPPAGAEALFRWLSERDGQNKVLNLNISNVPGPRERGRVGAALVTEIYSVGPLTAGSGLNITVWSYVDQLNISVLTDGSTVQDPHEVTAGMIADFIEIRRAAGLSVELTVVESAMAQA
The following text describes a protein:
Function:
Required for assembly of cytochrome c oxidase (complex IV).
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MMLALSTLKAASSSRAPVAARFNSTQAGNGPDASFGSATRSTVPPRSTHATYHPGGYGISQGLKRARKPYRVRNILTGSLIVAFATSVYFYSISKVKQDDFSDLAEIRAPTATDSVPVTTESDHKHQV
The following text describes a protein:
Function:
Transports carnitine, acetylcarnitine, propionylcarnitine and to a much lower extent medium- and long-chain acylcarnitines.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSSDTSLSESSLLKEESGSLTKSRPPIKSNPVRENIKSFVAGGVGGVCAVFTGHPFDLIKVRCQNGQANSTVHAITNIIKEAKTQVKGTLFTNSVKGFYKGVIPPLLGVTPIFAVSFWGYDVGKKLVTFNNKQGGSNELTMGQMAAAGFISAIPTTLVTAPTERVKVVLQTSSKGSFIQAAKTIVKEGGIASLFKGSLATLARDGPGSALYFASYEISKNYLNSRQPRQDAGKDEPVNILNVCLAGGIAGMSMWLAVFPIDTIKTKLQASSTRQNMLSATKEIYLQRGGIKGFFPGLGPALLRSFPANAATFLGVEMTHSLFKKYGI
The following text describes a protein:
Function:
Chloride/bicarbonate exchanger.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MRLDLASLMSAPKSLGSAFKSWRLDKAPSPQHTFPSTSIPGMAFALLASVPPVFGLYTSFFPVLIYSLLGTGRHLSTGTFAILSLMTGSAVERLVPEPLVGNLSGIEKEQLDAQRVGVAAAVAFGSGALMLGMFVLQLGVLSTFLSEPVVKALTSGAALHVLLSQLPSLLGLSLPRQIGCFSLFKTLASLLTALPRSSPAELTISALSLALLVPVKELNVRFRDRLPTPIPGEVVLVLLASVLCFTSSVDTRYQVQIVGLLPGGFPQPLLPNLAELPRILADSLPIALVSFAVSASLASIHADKYSYTIDSNQEFLAHGASNLISSLFSCFPNSATLATTNLLVDAGGKTQLAGLFSCTVVLSVLLWLGPFFYYLPKAVLACINISSMRQVFCQMQELPQLWHISRVDFLLQVPGLCILSYPTPLYFGTRGQFRCNLEWHLGLGEGEKETSKPDGPMVAVAEPVRVVVLDFSGVTFADAAGAREVVQVRERLASRCRDARIRLLLAQCNALVQGTLTRVGLLDRVTPDQLFVSVQDAAAYALGSLLRGSSTRSGSQEALGCGK
The following text describes a protein:
Function:
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
Sequence:
MTESSFKLAIVVSQFNRAVTEKLLNGVLQRLTELGVQANQIKTVWVPGAVEIPLLAKRLAKSKHYQAVVCLGAVIRGETDHYNYVCQQVSFGCQQVALEYEVPIIFGVLTTTTKEQAFARAGGERGNKGADWADAAVSMIKLMKEIEITDE
The following text describes a protein:
Function:
Stabilizes the HMG-CoA reductase HMG2 by preventing its HRD1-dependent degradation. Binds directly to the sterol-sensing domain (SSD)-containing transmembrane region of HMG2, promoting its folding to protect it from degradation.
Miscellaneous:
MISCELLANEOUS: Present with 1900 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGKKKSKNQLNTGGVPNGVHNTKKEAALPPLGNKLGSASFTAINTLTKPALFSFYDDDITKNEGNVYDKALLSNASQLEMVPPSATARHERSLYAKIINTIAAFFILFIAGILFPMISECLFDNDQLAKGDIVSFLKHGIEIKNKIVAEPDMVPDWAVFGTEGVIFGSIVPFIDSFVRYQHQPKTRSSVYKNTLGSFIRCANTLLGLIFGIRKLEWSSSLQAAGAWSLLNIVLWLFFDGTLTVFFPGLVIGALSAFTCSQCFSQLSLALYFIDFYFFGFLMFSKLGRYLFN
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MHNDTSPISSTIPSLLSNDVPTEINGTGSFSSSGPTPNSFSKENSRSGLLNAPSQIFASTRIPKNLSHASRPVSLHNASSSSSSVTNPNMFSNGSPSLLHGTSSISSYVTSPFLISGTTNSARKIPSCMTNPNMFSMKSPTLLHGTSSVSSSTTSPCLTCSTATSSTSLYSSNPTLLNSTSSISSSTASPSFLSPSSRSSSVTCLNLFSTKSPSLLNAANPITSISSPTLSYSASSTSSSITAPNLLTDQSLTSLNGRPSISIYTKSCNFLFGKSLESLCHNTPNSTASPTSLCGSGMDSSCTKCQISATSPDFPFASSLASSSDKSPISGASLDFPSGSSLASSRNKSPISTTTPSFLFGSSLASSRDKSPISATSPGFLSGPSPSMFFSSCSSSSSSAVTNPNILCDICPATPFDVTRPMTLLDVILKLQSDEATNYPYGTSQSYPAEIPSFPNPNSLSQQTIPNVCSPELTGTNLLSDEKPNFASDTNQISHPIHPSFSQASIPDFLSTESRVMLSCTRETPLEKILDFLSHYDSSYSLSDTYPNLLSDTSQTLVGLHDSLSGESRTLPTEEASLSHSNSGESNVSFLGKRPAFSSDEVLIIDLTEENGPYSILKDKVPNRKRKTVPSSSGYFCEICMDHKSHEEIFSNPTCFHSYCNECIAKHIASKLQENFTIISCPNPSCNQVLEIGSCKPYVPESVFQRWCDVLSEDSILVINKYYCPFRDCSGLLEFDAVNDGNIRESECPYCRRLFCAQCNVPWHSEMNCEEFEEVRGNKEHDILFSELAEEKNWKRCPLCKYYVERKAGCDHMTCSQCILNSILFQNLDLKLSALACALHWLRTNISKSMVYGK
The following text describes a protein:
Function:
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKDDSRSPSGSEPEGDNHKKEKRPIWAPIRVPPYRRIQTAAVLLWTSQLSLCISLFFFLMSYPITWPILLPYVIWILVIDPAPEKGGRLNQSVRTWKFWNLFASYFPISLIKTVDLPSDRKYVFGYHPHGIIGMGAVANFGTEATGFSEKFPGLNPHLLTLSTNFIIPFYRDLILSLGICSVSIKSCISILKSKNKRSADVKNNKGEGNCLVIVVGGAAESLSAHPGTADLTLKRRLGFIKLAIREGADLVPVFSFGENDIYAQLSNSKGTALYSLQKRFQAVFGFTLPVFHGRGIFNYSLGLLPYRHPIVSVVGKPIRVEQNKNPGLEEIEKVQKEYIAELTAVWDQYKDLYARNRKSELTLIA