lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May play a role in innate immunity by disrupting the interaction between PYCARD and NLRP3, thereby regulating the NLRP3 inflammasome. May also inhibit NF-kappa-B signaling distally by affecting the nuclear accumulation of RELA.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Recruited to specks formed by PYCARD within the cytoplasm.
Sequence:
MASSAELDFNLQALLEQLSQDELSKFKSLIRTISLGKELQTVPQTEVDKANGKQLVEIFTSHSCSYWAGMAAIQVFEKMNQTHLSGRADEHCVMPPP
The following text describes a protein:
Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Subcellular Localization:
Nucleus.
Sequence:
MELEHKLQLEHKYQFAVNSHGAFQELRNESMVTAAAAAVAQEQHRQQLHQQQQQHQQQQQQQQHQQQQQQQQARGRDGMKLKQNCSANASPEVKQILNCFILSRKSQAAASNGTTTTSPYRNRGVVKSSSGESLPAGTVTSAHPYKIPQPPPSLLKYESDFPLRKTASEPNLLKIRLKQSVIERKARIGGPAGARRHERLLQAAQRRQQKNSVLTNCNSTPDSGPNSPPSAAALAVGVVGSRGSPTSAPIQEENEEGSQYQPGQRSSINDLPLFSSPSLPNISLGRPHLPNSAQAHAQVNAQVAAQAQAQAQAQAQAHAMFAALAAAQGGCGQPGYYNPLGMAFVGRQPAPLAMIPATGIAPQQPSPVVRSASATSTSSSQASLVGDVAPPQAHAASTILPSSSSYMQQLGSVAGSGVNLHAAAVAAAAAAAAAAGSLPPTNSHGHGHGSHAHPHPHAHGHGHGHGHGIYAGHQHNVPITDAQVAQVHLHKQGHRPLGRTQSAPLPLGHPMLTGAVQLNVVQTHYENSEAERQAYEHQVVNQKVRQTVLTRSGAAAAAAAAAGVSVVREAQLKEEDDDSAAEVMDLTDKKKPPKTVLTSTIATSTSQNLPEALAAAAAAAAYRAPHNASSNSASATKSGIKLRDQEYLQQQREQLLLLQQEEELAKSLMRPLSRTLSSPLVPLGPHGLSQIPDTGQQPAPIATSSSADHIPPVNLSLPHRQHRQLMSTLYASQLRNHQPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHWPCVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDDSEEPMDQDETK
The following text describes a protein:
Function:
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
Subcellular Localization:
Cytoplasm.
Sequence:
MKFKDFFVIGTDTDVGKTYVSTLLYKALKKYNFQYYKPIQSGCFLKDGKLTAPDVDFLTKFVGIDYDDSMVTYTLKEEVSPHLASEMEGIRIEIENVKRHYEDLKKKHSNILVEGAGGLYVPLIRDIFYIYDLIKLFNLPVVLVCGTKVGAINHTMLTLNALDTMGIKLHGLVFNNYRGQFFEDDNIKVVLALSKIKNYLIIKNGQKEISDKEIEKFFN
The following text describes a protein:
Function:
Mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7 (By similarity). Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal (By similarity). PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX21 (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome. Note=Cycles between the cytosol and the peroxisome.
Sequence:
MSQYCAADPIQRMVSRKGPYLDTQQQRVYKHRSGTGHGTNIRQPTTGIVEATFLQNNSGMNAVHPTTLNVQTHNAHATGRTIAKSVDTNSWVNDFSSMKVQDPLEFADSYKNLYKQYEQKQFHNTVPAQCPRNLYIPTVTRPQTTLNIVDHHEDKSSAVDQLIDDEFEKIEEEVKDQNQKLEFQESAQSFIEICERSQMKEKLQRSKFFQVMQKVSDGEATIRQDGENYVIR
The following text describes a protein:
Function:
Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MLRCNISQRVPTHPVVSVKSGLVFERSLVEKYVDEHGRCPVTGDPLRKEDLITAQGAAPDASIASSGSLGAASVPTLLERLQVEWEGVALEQFSLRQQVTQLQLELAHALQQYDAACRVIARLSKELDSLRGGKAVAAEETDKGPAVVVVPAPVLRRMDAAEAAERQARKQRKAAAGSTAATPSQLTEEAQWVATPSSSASASSARSAVRVAAAADASSSGVFVSAVTGDHAIVRYSPDGFSEEARGIGHTATVHTLASQPGDILLSAAEDLTVRVWSTKGAALTVMHTLRYASGVVAMSQRTVGGAYMLCGAGDGVLTLSDLESGAHVVATAPLTLDTTSGALTCVELHPYASLAAVAFQPTELQLWDAREMRADTFISHVRGTAPRTHICSASFSADCVSLAAGLTDGSVYVWDLRQVLAPVAVLPPSADAVPATVRYAPDGRSLVVGGHGVTLYDCARLSASSTAVEAVATAGLKASAVCDVCWTTSGTDVLCGSVDGVVRLYSTAAGAT
The following text describes a protein:
Function:
May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Dubious isoform. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Nucleus.
Sequence:
MVVLRSSLELHNHSAASATGSLDLSSDFLSLEHIGRRRLRSAGAAQKKPAATTAKAGDGSSVKEVETYHRTRALRSLRKDAQNSSDSSFEKNVEITEQLANGRHFTRQLARQQADKKKEEHREDKVIPVTRSLRARNIVQSTEHLHEDNGDVEVRRSCRIRSRYSGVNQSMLFDKLITNTAEAVLQKMDDMKKMRRQRMRELEDLGVFNETEESNLNMYTRGKQKDIQRTDEETTDNQEGSVESSEEGEDQEHEDDGEDEDDEDDDDDDDDDDDDDDEDDEDEEDGEEENQKRYYLRQRKATVYYQAPLEKPRHQRKPNIFYSGPASPARPRYRLSSAGPRSPYCKRMNRRRHAIHSSDSTSSSSSEDEQHFERRRKRSRNRAINRCLPLNFRKDELKGIYKDRMKIGASLADVDPMQLDSSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQIYTTSEKLQLDLSSINISAKDFEVAMQKMIPASQRAVTSPGQALSTVVKPLLQNTVDKILEALQRVFPHAEFRTNKTLDSDISCPLLESDLAYSDDDVPSVYENGLSQKSSHKAKDNFNFLHLNRNACYQPMSFRPRILIVGEPGFGQGSHLAPAVIHALEKFTVYTLDIPVLFGVSTTSPEETCAQVIREAKRTAPSIVYVPHIHVWWEIVGPTLKATFTTLLQNIPSFAPVLLLATSDKPHSALPEEVQELFIRDYGEIFNVQLPDKEERTKFFEDLILKQAAKPPISKKKAVLQALEVLPVAPPPEPRSLTAEEVKRLEEQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPDYVTVIKQPMDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRACALRDTAYAIIKEELDEDFEQLCEEIQESRKKRGCSSSKYAPSYYHVMPKQNSTLVGDKRSDPEQNEKLKTPSTPVACSTPAQLKRKIRKKSNWYLGTIKKRRKISQAKDDSQNAIDHKIESDTEETQDTSVDHNETGNTGESSVEENEKQQNASESKLELRNNSNTCNIENELEDSRKTTACTELRDKIACNGDASSSQIIHISDENEGKEMCVLRMTRARRSQVEQQQLITVEKALAILSQPTPSLVVDHERLKNLLKTVVKKSQNYNIFQLENLYAVISQCIYRHRKDHDKTSLIQKMEQEVENFSCSR
The following text describes a protein:
Function:
Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle.
Sequence:
MASGVKVDPSCKNAYDLLHNKHQHSYIIFKIDKNDTAIVVEKVGEKNAPYAEFVEEMKKLVEDGKECRYAAVDVEVTVQRQGAEGTSTLNKVIFVQYCPDNAPVRRRMLYASSVRALKASLGLESLFQVQASEMSDLDEKSVKSDLMSNQRI
The following text describes a protein:
Function:
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Subcellular Localization:
Nucleus.
Sequence:
MPRTTRSKASTADSQDAKSSSSSSSSKTKSKSTTSSNSSIYTLAPEVESPPSIFILPKSATPQSRIVTLQNPRYAKPTRYLVCPDSGTFYEFTKIAAPQQKSPRSWLIDSAKLQDGTTAITPAQTTKDSELYVATQIDPLFLVLPALAAADKKQQRMFLSSDDHFDAVSEQDSDGKRQNHLLEVLKWPQARNLLEKRMAAVFDTVEAGDETMFRLNESKLVEELLSKAKRMSEGGLPKSMEEKFVAKALEAPIVGIRTTVLSRSDTTVSTESQEETTTTTSSLSEATTAVATPTSGTGAEVIPSLIPTPEILTLQRLRVSLNFLTSSYLPPSLSSHLKSSLSSPSSVDFSLLDSYLAQLAKLRQEAVASRSHSDFSRKRIAGDEEEAFERAEKRRKKEEEEKAKKAGVSRGVKELAKVNTRGMMKLTSFFQKKT
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
Sequence:
SQDGIKKLLEAERTAQKIVNDARQDRVQKLKKAVEEAEKEIKEFREKKDKEYKEYESKYFGASTETATQLLQSANEEIETIRTETAANKEKVVDLLIKYACEVNNKNIKV
The following text describes a protein:
Function:
Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.
Subcellular Localization:
Cell membrane. Cytoplasm. Endomembrane system; Peripheral membrane protein.
Sequence:
MSHHSDDQLLQAGSDSFWEPGNYKRTTKRIEDGYKLCNDLQQLIQERADIEKGYAKSLRTWSKKWGELIEKGPEYGTTEAAWKGVLTESERISDVHMKIKDNLCNDVNSQIKTWQKENYHHTLMQIKERKDLEDLFKKAQKPWAKLLAKVEKAKADYHSACKTERSATNQERNANADSSLSPDQVKKMHDRVQKTKDQVQKCREKYEQAIAEITKYNSVYIEDMTSVFEKCQTFEKTRLQFFKEILFNVHSCLDLTKVQSLPQIYEEFSHTINNADQQKDLKWWSNNHGINMAMNWPSFVEYTEEFRDIAKGNKSKEALPAAPITLINQRPVAEDVHQEYPQTNSLKKNTSTLSSVSSRASVKSEIATTQSSVTTSEAKTSAAVAGAATATAAATAASAASNRNSSVTNGNGKVDANPFDEEEEWDESDNVLVDNGEPGVPVKALYDYEGAESDELTFKQGDVFEKLEDEDEQGWCKGRMNGRVGLYPANYVETA
The following text describes a protein:
Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.
Sequence:
MAFSSVTTQPLPFGVEREKHIDLLFRTFHRQIRPAGDTQDLTLVLQDRGDHEGPANTHTESKTLGKLTALRTVTRLHITARPELQGPQCVARRTYSICSENRDQLFVAVEESSCMCMQCCGPARSCSLRGFDKDSECVFLFERPLRADMCCLGCCLMEIRAYTAERELIGTVHQRWSMFTPYLEVCDSEGISAMRIQGSCCNTRCLSEQELQVVSTIGESIGRIWKKWPGYNDKCNMDHEYFGLDVPQEMSLNTKVLLLAAAFLLNHMFFEMS
The following text describes a protein:
Function:
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Subcellular Localization:
Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasm, cytoskeleton.
Sequence:
MMHTFENTFIRGPSPSYSDDANSENALSVTLPIGGVVPDLDFCRDDSKTDTGDYFDEKYNSDSCSRLHPGHQGRNTFAFWTIVVLLLVLTVGNLLLTLTIVGVLRLGKGVQGMEVIPEVDLVKFYGTTDLERVQTNSIGQIHGFSDVPVTISSDAGDGEGGVHVRVFRNGNGAASERDRIVLNREGILVQATNLFEVKDPVDKQPIFTTHRPQYNIPGGVEALQAKVVSASGIVSPIDESLVLESDGRMAIRGSEGVYFDGASVDMQAEHHILINSTQGATILEAGTGIFLDMDRIPIVSSELGLRTGSVQYKICVCMPHGTLFRIAIPRVHNGPKITCAHFSGKDDPCEIN
The following text describes a protein:
Function:
GTPase involved in protein precursor import into chloroplasts. Seems to recognize chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis.
Subcellular Localization:
Plastid, chloroplast outer membrane; Single-pass membrane protein.
Sequence:
MGSIVREWVGFQQFPAATQEKLIEFFAKLKQKDMNSLTVVVMGKGGVGKSSTVNSLIGEQVVRVSPFQAEGLRPVMVSRTMGGFTINIIDTPGLVEAGYVNHQALELIKGFLVNRTIDVLLYVDRLDVYRVDELDKQVVQAITQTFGKEIWCKTLLVLTHAQFSPPDDLSYETFSSKRSDSLLKTIRAGSKMGKQQFEDSAIEVVYAENSGRCSKNDKEEKALPNGEAWIPNLVKAITDVATNQKKAIHVDKKMVDGSYSDDKGKKLIPLIIAAQYFVVKMIQGAIRSDIKISGKPL
The following text describes a protein:
Function:
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
Sequence:
MKNKKPIFVVFEGIDGSGKSTLCKSLTEKLIELGIPSAAFTEPTNLETGKYLRKFLRGEIELGKEEQIEAFLNDREESLKQNILPALNSDKNVLLDRYMYSTAAYQSGDDLSPEMILKKNLNRNFKIPDLLFYLDLSPSIALERLNRRKEGKERFETLAQLEKIRSAYEKILPKDTIRIDGNKNQNQIVQECLEIFLTNIKSKS
The following text describes a protein:
Function:
Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MERKRGTAGPAGPPLDGGYGWFIVLSTFLVFGLTFGVIKSFGVFFVEIHHYFSTTATASSWITSISVATVHIGAPVGSALSTYFGHRPVVMAGGLLSSVGMVLGSFAQDLLQLYITVGFLTGFGYALTWTPTVTMLGWYFDKRRPVANALSSTGECLLTFILTPSFQLMVDQFSWRGAMLILGALQLNLCVCGALLRPLSRHDYFKDSIEENEHELSKCSNNRADSDPMKVKVIRYVDYTLIANSRFMVYSMFGIFAALGFFAPSLFLVPYARSQGVEEYQAASLMSISAVLDLLGRVFFGWVANLRLVETVHQLIGTVVLLGAVLLLCPLATTFTQLAVFSAGYGLVFGATVAIHITVLAEVVGVERLGSALGFFMLIRSSGGLLGPPLAGIFIDKMSDYGAGFLMAGVALLVSALFLIVLHFMNKKETEHKKDICSENEEEHEDLKNRNFVFGKS
The following text describes a protein:
Function:
Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells.
Subcellular Localization:
Nucleus.
Sequence:
EGLEGRETSRAGLWAPWLSPEVSFLISLLFLSEGSTGVPDCTRTGADTLWLRRETGALVKQIEKRDSVLTSKNQIERLTRPGSSYFNLNPFEVLQIDPEVTDEEIKKRFRQLSILVHPDKNQDDADRAQKAFEAVDKAYKLLLDQEQKKRALDVIQAGKEYVEHTVKERKKQLKKEGKPTNVEEDDPELFKQAVYKQTMKLFAELEIKRKEREAKEMHERKRQREEEIEAQEKAKREREWQKNFEESRDGRVDSWRNFQANTKGKKEKKNRTFLRPPKVKMEQRE
The following text describes a protein:
Function:
Positive regulator of acetate induction.
Subcellular Localization:
Nucleus.
Domain:
The glutamine-rich domain might function in activating gene expression.
Sequence:
MPGILPMKVIKVGNSSQSRIAQACDRCRSKKIRCDGIRPCCSQCANVGFECKTSDKLSRRAFPRGYTESLEERVRALEAEIRELKDLLDEKDEKLDMLSKMHSNRSRSAEPPRSTPAAEIKRDSGTPAKEDTFRVQASPLLLGVENSDSYFMGASSGRSFIETFKRKIQENGKSCTDFNPEAFLHIQGCYPLSTKLAPQSMRIPPRLFSDRCVNVYFQEWAPLFPVLHKPAFLRVYEEFVADPEKIKNNHKLTQLYLVFSIAGLSSEQPDFQQLAACETQWHKSLEAVLMDNTMLTLQCLILALMYCTVRADYKRLQYYKGIAVGLSHRLGLHQSQKRFSFGALTIETRKKVFWTLYTLDCFSAAILGLPKLLKDEDVHAEFPSDTDDENVTEKGFQPSLPGEPTRISSALALFRGSRILGKVLEKIYPAATSYELSLQQMSSLEGELTEWFENLPQHLKLNFKQDKPSTDVTGSRSPLLALAYYYTRILIYRPAIASSLGPKAAPALMSVAESSKSIVQIVQLLEERSMSFSFCLNKADILIVCGMALLYQTLGLKHDSKVLKDNEKLVNSVVKIVTKVNAPGSYDFKRIAGMLVTVEESLPQSLPTPPRQSPEACMPTPPAQQGSPSPSAVDRGAQPNLARQSSASLSETDLIVQRDKLLGMAVTPQHQQYQHQQLQQQHKNELSRARSQTSFDNLRQKAQQMRPHHRHSLSHAQVAQAALMGRTSTGTQSTPNLDYLSLSSPQSPVSPVQMRSQPHQLQQQQQQQPQPQQQQQQHQRSSIASSHSQQGQMFPQKTSTGMSTAEWEALVRSLDGGPVSLYTAIYGGPALAPLETPSSATQSSATAWGQDPWDMSSFNLGDFVPGAPTAQSVLSLSEESISSCDDVPSSDMGLNNGNMDYRNTLLPVTSAGTNNFLLDGLHGYGL
The following text describes a protein:
Function:
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
Sequence:
MKLAQLFSNFEEELIRQGEEAESLSFVYRSLKNLSFTDFIFALQQEVTTEEEKQFVEDIYQQLAAHKPAQYIIGQADFYGMHLKVDERVLIPRPETEELVELILTENLETNLSVLDIGTGSGAIALALAKNRPDWSVTAADISQEALDLARENAKNQNLQIFLKKSDCFTEISEKYDIIVSNPPYISREDESEVGLNVLYSEPHLALFADEDGLAIYRRIAEDATDYLKDSGKIYLEIGYKQGQCVPELFRKHLPEKRVRTLKDQFGQNRMVVVDDGQD
The following text describes a protein:
Function:
Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSSPPLSSPVPQVKTTQNGKSPDATVHLLAGAIAGLVSAVTLQPFDLLKTRLQQQQLTTKQEVRTTLTKELKKLTRVKDLWRGTLPSTLRTSIGAGLYFTTLSKMRTSWGEYKQSKDSSINLKSNSSILPKLTAMENLTTGFIARGIVGYITMPITIIKTRFESNLYNYNSMYEGISGIYLDDKKQQQQIRNPSINKGVGGGGSWKNFFKGSVATLARDCPYAGLYVLTYEAFKNDLIPLIIPNSSLSLSSSSSLSSSSSLFVFNDNNRSSIINSTAAVLAASTCTTITAPFDAIKTRLQLTNEEGGSMTTVLKKMLREDGGIKNLFRGLSLRLGRKGISAGISWCIYEELIKSNYFQSKFL
The following text describes a protein:
Function:
May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity).
Sequence:
MSNARQRELIREFLAVTSATSAAAETYLERNHWSLDHALDDFYTQSGGGGRAEQYSAELVATFERYAAGGAMDTEALVRYVGDLGFQLEDVATLCLARLLKVEELTADISRFQFLSTWHGLGCSSLPDMRAAVDALELRLRTDAAYFRALYAYTFGLGLDAGGRRLSVETAIAYWSLFFLDHTYAVTVPAPRLRSWFEFLRAGDHSVSRDTWDMFPRFAQRFPDDTELLEHYNELASWPLVIDEYYEWVKGRNQL
The following text describes a protein:
Function:
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity).
Sequence:
MISAKEVEDAYDLLKAVVTKTPLQLDPYLSNKYQANIYLKEENLQKVRSFKLRGAYYSISKLSDEQRSKGVVCASAGNHAQGVAFAANQLNISATIFMPVTTPNQKISQVKFFGESHVTIRLIGDTFDESARAAKAFSQDNDKPFIDPFDDENVIAGQGTVALEIFAQAKKQGISLDKIFVQIGGGGLIAGITAYSKERYPQTEIIGVEAKGATSMKAAYSAGQPVTLEHIDKFADGIAVATVGQKTYQLINDKVKQLLAVDEGLISQTILELYSKLGIVAEPAGATSVAALELIKDEIKGKNIVCIISGGNNDISRMQEIEERALVYEGLKHYFVINFPQRPGALRTFVSDILGPNDDITRFEYIKRADKGKGPCLVGILLSDASDYDSLIDRIERFDNRYVNLHGNDSLYELLV
The following text describes a protein:
Function:
Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MKQYLIAPSILSADFARLGEDTAKALAAGADVVHFDVMDNHYVPNLTIGPMVLKSLRQYGITAPIDVHLMVKPVDRIVPDFAAAGASIITFHPEASEHVDRTLQLIKEHGCKAGLVFNPATPLSYLDYVMDKLDVILLMSVNPGFGGQSFIPQTLDKLREVRRRIDASGYDIRLEVDGGVKVNNIGEIAAAGADMFVAGSAIFDKPDYKKVIDEMRSELAKVTHG
The following text describes a protein:
Function:
Sodium and pyrimidine nucleoside symporter of the plasma membrane that imports uridine, thymidine and cytidine into cells by coupling their transport to the transmembrane sodium electrochemical gradient. Also transports adenosine, an atypical substrate transported with high apparent affinity, but low maximum velocity. Therefore, exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit). Involved in renal nucleoside (re)absorption.
Miscellaneous:
MISCELLANEOUS: Can also transport the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.
Sequence:
MENDPSRRRESISLTPVAKGLENMGADFLESLEEGQLPRSDLSPAEIRSSWSEAAPKPFSRWRNLQPALRARSFCREHMQLFRWIGTGLLCTGLSAFLLVACLLDFQRALALFVLTCVVLTFLGHRLLKRLLGPKLRRFLKPQGHPRLLLWFKRGLALAAFLGLVLWLSLDTSQRPEQLVSFAGICVFVALLFACSKHHCAVSWRAVSWGLGLQFVLGLLVIRTEPGFIAFEWLGEQIRIFLSYTKAGSSFVFGEALVKDVFAFQVLPIIVFFSCVISVLYHVGLMQWVILKIAWLMQVTMGTTATETLSVAGNIFVSQTEAPLLIRPYLADMTLSEVHVVMTGGYATIAGSLLGAYISFGIDATSLIAASVMAAPCALALSKLVYPEVEESKFRREEGVKLTYGDAQNLIEAASTGAAISVKVVANIAANLIAFLAVLDFINAALSWLGDMVDIQGLSFQLICSYILRPVAFLMGVAWEDCPVVAELLGIKLFLNEFVAYQDLSKYKQRRLAGAEEWVGDRKQWISVRAEVLTTFALCGFANFSSIGIMLGGLTSMVPQRKSDFSQIVLRALFTGACVSLVNACMAGILYMPRGAEVDCMSLLNTTLSSSSFEIYQCCREAFQSVNPEFSPEALDNCCRFYNHTICAQ
The following text describes a protein:
Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Targets AAH1 adenine deaminase for proteasome-dependent degradation upon entry into quiescence. Targets also URA7.
Sequence:
MSEVESREKEPDAGLSPDIVQATLPFLSSDDIKNLSQTNKYYNTLLDFDHSKILWHELFHKAFGTLKTNDEPFQGRNSAEFKTCTETILREAFPTLSWQEVYQLRAYDAKFYSWGYLKHGRLGYTASSNNELVATSLNGPSPRFKYGVNTPTEVPWFNSRTTSRTSNFTPSEDPLSAIKKDGDEIIAQVSSGGFSFQILTESGNLYSSGSTFSGGLKGPGPSGSQHDYNPFREMIHNMERSYPRITSRSNGSTVNTTGTFSGRRMSGSHPSTAYEPGNATTAQHITIDSGGAPAASPGGSHSGVPRTTMPSMGPHENIYSQIEMLERSANKAVPGNNHIRRMFARNSFPLYSGRDENLGSFNDIQFVAVSSGRSHFLAMDTDNNIYSWDSTESDQGVKIEFANLPSRATNPILKIASGWNFNCCYIYKVGLVAWKERDAIQKGESFAFAKYEIVPNTNDVNGDSRIVDFACLQDNCVFFINNNGDKLWKYHNGLNQIVDLNIVGKLCKINACFASLVLFTDTHCYTLKVTNGDVDKDSLTELDINENVISVASGDYHTVALTERGHLYSWGIESQDCGCLGLGPSEKIVNELHIGNWEGQRNIRVVKPTKIELPEDYICVSVTAGGWQTGALIIKKH
The following text describes a protein:
Function:
Proteoglycan that seems to be implicated in diverse developmental roles such as differentiation, cell-cell recognition, embryogenesis and programmed cell death.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MTRNILLTVTLICIVFITVGGQSPATAPIHSPSTSPHKPKPTSPAISPAAPTPESTEAPAKTPVEAPVEAPPSPTPASTPQISPPAPSPEADTPSAPEIAPSADVPAPALTKHKKKTKKHKTAPAPGPASELLSPPAPPGEAPGPGPSDAFSPAADDQSGAQRISVVIQMVGAAAIAWSLLVLAF
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Miscellaneous:
MISCELLANEOUS: There are at least three nodD genes in R.meliloti. They differ in their specificity of interaction with different flavonoids and, consequently, contribute to the nodulation of various plant host species to different extents.
Sequence:
MRFRGLDLNLLVALDALMTERKLTAAARRINLSQPAMSAAIARLRTYFGDELFSMQGRELIPTPRAEALAPAVRDALLHIQLSVIAWDPLNPAQSDRRFRIILSDFMILVFFARIVERVAREAPGVSFELLPLDDDPHELLRRGDVDFLIFPDVFMSSAHPKAKLFDEALVCVGCPTNKKLLGNISFETYMSMGHVAAQFGREMKPSVEQWLLLEHGFNRRIELVVPGFTLIPRLLSGTNRIATLPLRLVKYFEQTIPLRIVTSPLPPLFFTEAIQWPALHNTDPGNIWLREILLQEASRIDPQSDTC
The following text describes a protein:
Function:
Component of the intraflagellar transport complex B (IFT-B) involved in flagellar assembly (Probable).
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, flagellum basal body. Note=Localizes to the cytoplasmic and membrane-bound portions of each of the eight axonemes, localizing particularly at the flagellar pores and at the distal flagellar tips. Localizes to the basal bodies.
Sequence:
MILSYSRNLYPQSTGEKIVMGIDWSPNSQKLGVLTADHSLYLFNDQGERQDKIGLRSTEVKSSNKDFIPLCGTFSPCSTLFVVGQSDKVAYIFRLGQLWTDKKSIVARIPMDDAVTAVSWPLSEATSELSPIIFGTASGNLYLYSFQSKSIQAFVSSACFASLASSKTTTADNQATPLSPMSSPIIKILPIPSMPQCFVAVAESGLAVYVDIKTQQLRAAARHSKAVTTACMIAQKTSHGRHYLVLADVMCKVTVYAVETSAALCVCNIKTPQNIPFTASTASPSGGGCIVANASGLHFLTLVNSQPVTVSYEASSSAVTVYQDSGKGFLPQITSIAWRPDVSVLTVGTSLGSVDNFTPTIGSYRYCGAEVVNSAPNRATINIPRFNGSKRFAAGSIDLHASMSSELRTVKAFPKHDFTSFVQNPSGYKSTNIYLLGIGDSSIVIYSLNDDTINEFRYNASLTDKFFFDVGACRTMVISNTLGEFTVCYLTTQSDPGCTFYKVDIYATMRGCVAPHASVISCYPIYEDAAGSLNRISKIRTVCLGEERTDVLVTDLMPPDMCDDFSDPIVVLFRTKTSRAVDWLFFGPSGNAVLLRDISGGVSILNITDYSITQLSTSVGNGVVQWADPFDVIVGQESPDAPLYVWYNPTDIEDAPEILQPPVPVDNESWSFSYVKSNPNNFSKITAGHVKNISVQAIMTTPSGRQTSVSLDTNLLLFNLLLDKHDILGACQLLSALQDNNARVTNRNLWQKLCSVALDSFNFIVASRCYAALGDLPLSITAREIHERVQNAKDGEAGMTHDRMNLYCQAQIALLNSDLDKYDGLMMSCGRIDEVLTLYKELNLYSRAEKICPESMINTLRTEAIQWLINSGQMTTAGMLLAQRGDVRGALDLLIQDRSYLSAFELAKRAMTSSADPSLAPIIELLIGKLEDSHHYSQAAVLCTLGSGRNHERALALFRKSHAFDEALELARQHLPHECLPIEREWAEWLFQTGQYDKATQHYLECMNQEMAVESAFRANNFKLVESLLMDIPAAETNAHLCFRLAEMKYISGDAAGAATWLLKADQPLLGLSAFICAGKFDEAIQFIRSNLPRQSYRELLVHEAKRIISLGSAPSNNPVQEKTKTLTSSGVFASSSGESSEKQNVQSFLNRMESLSHIRGVYSAIELLKLAGLYEDVADILQGNSMWDELYSFAKEHAASFSNYPDILRMVADAKRVKGDKKSCATILEELCMELYGLSGSSSGSSGGMGAATDGYTRLRTQASHLIQARRDVLLEASSMYCDLFMYLEAIRLCKRCGDMDALTDVCLLWVSSNANRSLLIQQLKQLNIIEPTLTKAADRGMWDVCTELSEYCPDPEAVRCDLFWRRGRKLEIEGRLKEAEEFYAKAGKHQEIVGMYLDTGKFEDAQQAAMEMTSNFERERAMRSIRESKARVLASEGKWREAEAEFIELGLVEDIISIYRSNQMWQDALRVAKEHGDSVLVENLSESYVKHDKLRSGLGTSASAFEPGAKADLGDGSGLAGRTKQHGSDVQTARSILEAGSSAGLRKMLMSAARSGSDVLFEVVLHRCAELASMVLNNDIQDSSIVEDIAIISPSIHNFEEIGSPHERVMSLAVAYLSKGVPLSVTTGTESKGTISLIISDVCNREQLLLVCRGVLSLAFVESEYVNRITKQETHGDGIFCRLRSILLSYRNMLLNTVRGTKAAETDKVNFIPGDQELSRCFEATHLIIQLAKLFIGAKTISSMRDIVLVSSSLVRYCDLLPVDRCFVVAGESCKQFVEISNGNSNAKVMEARTQYLNQCCVFLNKFIDLHEEISNHSRNLERIDISDLTGSGIPWTAQVPVNLYLSKSRADEVRAFILELTMDESTTTTQELPREPCPFGCGKPIWIGACSCINCRQVSPICAVTGCHVINPNTHMLPSSRACQICGCYARPAPWNSLITKSKNCPVCEEVGFPIGK
The following text describes a protein:
Function:
No E3 ubiquitin-protein ligase activity observed when associated with the E2 enzyme UBC8 in vitro.
Sequence:
MGQSMSCGSRPEHGIFASVQCGDIITIRRVMATEPSLLNQTTPYDRHSVLHVAAANGQIEILSLLLERFTNPDLLNRHKQTPLMLAAMYGRISCVKKLAEVGANILMFDSVNRRTCLHYAAYYGHANCVQAILSAAQSSPVAVHWGYARFVNIRDDKGATPLHLAARQRRPECVNVLLDSGSLVCASTSVYGSPGSTPLHLAARSGSIDCVRKLLAWGADRLQRDASGRIPYVVAMKHKHGACGALLNPSSAEPLVWPSPLKFISELNDEAKLLLEQALMEANREREKTILKGTAYSLPSPSFSDTDDNMSEVSDTELCCICFEQVCTIEVKDCGHQMCAQCTLALCCHNKPNPTTSTVTPPVCPFCRSTIACLVVAQNNNNNNEKSKSLDDVVVVDREAGDVSSSKFRKHRRSINLGEESSSFMGLSTIGSFGRITGRGSGRIAAENELMDKPIL