lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by UV irradiation. Adapter protein which binds to the checkpoint kinase chek1 and facilitates the phosphorylation and activation of this kinase by the ATR-TREX1/ATRIP kinase complex. Also associates with chromatin during S-phase, and this requires the pre-replication complex (pre-RC), cdc45 and cdk2. This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.
Subcellular Localization:
Nucleus.
Domain:
The CHEK1-binding domain (CKBD) contains 2 potential CHEK1-binding motifs (CKB motifs). Phosphorylation sites within CKB motif 1 and CKB motif 2 are required for interaction with CHEK1.
Sequence:
MAALCEEEQVFLEPEDISLKIVETDSDSGQGSCEMADQNKLLGCVEDKDTDDEILVRKKSKKKEVLVDSDSDEELEMRNFADNVKGHSDNEENEETMSAYREKPRKIRSAVLDSDNSDHELDVQISTSQNAAEIPESEHDSLEKETHTVKPKTSKSLKKQTDTNKEEIVKNKSKRKIPKEKIKRRTKQKSKAVAEARPNLNDSGCLLTDGDLFDNGVENEMDSNEEEDSLEAIRAKMKSKLNSHSAENFEDFELDTEGNQESPEKRKERKAARLGKEAMKQMHSETQRLIRESSVSLPYHLPEPKTIHDFFKRRPRPLCQGNAMQLIKSTKYQPCTEEKKKPNEEICAEVPEFDYVSKEDLEISPEQPLLNTQCSHAAVLCVVQNDARTEGLSKSTEAVVTGQMNDHEDAFSDSNIVHEQETVGLITVTETFQTPFIPQPESVVCEQIQNDVVEMQRMPEQPTHKPKLSKLEKLKALGVDLSIKPRLCPDDGSFVNLDEPKPNKEFEALKERFLKHTLQKSKPRTERKVNLNIIRKETTADGKEELKADVVPIVMATEKPDKSIYQKPGEKLQVLKVKLQEAMKIRRSEERLKRQALYKLDNEDGFEDDEEEEEMTEESEDDGDGNAETADYPGGEDEEEVGDAEDDNDEDDTVNDRLLGNVPEIVIPLPRPVTTDSSLMLFKDNSSKLGDSLPDESGCKRSSRLEYEEDSLLPQLKENSHNSSFELISSMIPSYQPCNKTTRVVINSNNLGFRSPSPVHFKTSFLSSASKSSGKMSEPSLPVEDSQDLYNASPEPKASYLCAGRNSQFQFSLEDDTQSQLLDADGFLNVGRHKSSSAKHRLALDTMDENAMDANMDELLDLCSGQFKESLSGTSQAAESDAKKQPMDELLELCSGKFVSQADCSTQDSSASAKDRSTAVKKDISDEVATVSSSFLTEREQEEDEEEEFGEFKLLPCDDSESENEEQNEEEEEEEDAKDDEDEEEILQKQQKRKLRLNDFMEDEAELSGSDVGSGDEYEGDDDEYEEEAIDEDLPSDEELQDQVNKIHMKVTMDEDQRQLRFYQERYLADGDLHSDGPGRTRKFRWKHLDDASQVDMFRRDSELEEVDGENEETEETELKWRKERFEREQWLREQPQGSRDNNEEEEEDIGEDSQFMKLAKKVTAKALQRKVSTETNEPKKPGPRNPYEVIRPFSLPKLRTGSLLSKPKEVLQKLAAVSDLNPNAPRNSRNFVFQTVSPGKKEETTDKPRSKVRKNIAVAMPSPKRFKRDSTPTVKSRSIFQLLE
The following text describes a protein:
Function:
Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNSLVATPPVPPHIYEYSRLSPSRPMSTPSHTPTTNRKRKAEDEHNDFDSRMSASPTNSPAFTPRTLPSSSRQIKRARPNMGGRPLSLPRLLETLDTDALRGVLRSICDRHPNLADEVVQTAPRPSVASALQVLRNYQSALQSSFPLGGNPESDYAYNRVRQPLGNLLEALSDFTPHFLPPNETQPSISLSYLDDVTEIIHQLPRWSSPQNNIERDSAYDEICKAWILVIREAAKRGGGIQLQYGGWDQKLAKHNQNSGGRLQAAVNDLASSLGWMHGPESQGFGSPGGNDLGSIREQLLSGTYGLGTPVKVGPW
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
Subcellular Localization:
Mitochondrion. Mitochondrion inner membrane.
Sequence:
MANRFRSGISFFKTIAVTDSVSSVRSKSLFPALRTYATASAQTTANVKVPIALVGENGNFASWLYIAAVKMNSLEKIETDLSEMIEAMKTAPIFAQFTKDPSVPRGTRLAAIRDACDQAKFAEPTKNFLSLLAENGKLKNLDAIVKKFMQLTNAHRGDVKVLVTTVIPLPPAEEKELTETLQEIIGAGKKITVEQKIDPSIYGGLIVEFQQKVLDMSIRTRAQQMERLLREPVDFNNL
The following text describes a protein:
Function:
Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAQKHPGERGLCGAHHSGGASLRTLGPSVDPEIPSFSGLRDSAGTAPNGTRCFTEHSGPKYTQHPNPAHWLDPSHGPPRGPGPPRDAEDPDQSETSSEEESGVDQELSKEDEAGYQEDGNPSFLSIPSACNCQGTPGIPEGPYSEGENGSSSNFCHHCTSPALGEDEELEEEYDDEESLKFPSDFSRVSSGKKPASRRQRHRFPTKEDTREGGRRDPRSPGRHRLGRKRSQADKRRGLGLWGAEELCQLGQAGFWWLIELLVLVGEYVETCGHLIYACRQLKSSDLDLFRVWMGVWTGRLGGWAQVMFQFLSQGFYCGVGLFTRFLKLLGALLLLALAVFLGFLQLGWRFLVGLGDRLGWRDKATWLFSWLDSPALQRCLTLLRDSRPWQRLVRIVQWGWLELPWVKQNTNRQGNAPVASGRYCQPEEEVARLLTMTGVPEDELNPFHVLGVEATASDVELKKAYRQLAVMVHPDKNHHPRAEEAFKVLRAAWDIVSNAEKRKEYEMKRMAENELSRSVNEFLSKLQDDLKEAMNTMMCSRCQGKHRRFEMDREPKSARYCAECNRLHPAEEGDFWAESSMLGLKITYFALMDGKVYDITEWAGCQRVGISPDTHRVPYHISFGSRIPGTRGRQRATPDAPPADLQDFLSRIFQVPPGQMPNGNFFAAPQPAPGATAASKPNSTVPKGEAKPKRRKKVRRPFQR
The following text describes a protein:
Function:
[CLE27p]: Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance.
Subcellular Localization:
[CLE27p]: Secreted, extracellular space.
Sequence:
MTHAREWRSSLTTTLLMVILLSYMLHLFCVYSRVGAIRIFPETPASGKRQEEDLMKKYFGAGKFPPVDSFVGKGISESKRIVPSCPDPLHN
The following text describes a protein:
Function:
Transcription regulator that probably binds to the GCC-box pathogenesis-related promoter element. Also binds to the S-box (5'-CACTTCCA-3') photosynthesis-associated nuclear genes-related (PhANGs-related) promoter element, and thus acts as a transcription inhibitor. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways. May have a function in the deetiolation process. Confers sensitivity to abscisic acid (ABA), and regulates the ABA signaling pathway during seed germination, upon nitrate-mediated lateral root inhibition, in hexokinase-dependent sugar responses (including feed-back regulation of photosynthesis and mobilization of storage lipid during germination), and in response to osmotic stress mediated by NaCl, KCl or mannitol. Plays a role in sucrose sensing or signaling, especially at low fluence far red light. Also involved in plant response to glucose treatment, especially at low concentration and in young seedlings. Required for the trehalose-mediated root inhibition and starch accumulation in cotyledons, probably by inhibiting starch breakdown. However, seems to not be involved in sugar-mediated senescence. Required for the ABA-dependent beta-amino-butyric acid (BABA) signaling pathway. BABA primes ABA synthesis and promotes resistance to drought and salt, and leads to a prime callose accumulation that confers resistance against necrotrophic pathogens such as A.brassicicola and P.cucumerina. Seems to be involved in resistance to S.sclerotiorum probably by regulating the ABA-mediated stomatal closure apparently by antagonistic interaction with oxalate. Negative regulator of low water potential-induced Pro accumulation whose effect is decreased by high levels of sugar.
Miscellaneous:
MISCELLANEOUS: 'Salobreno' means 'salty land' in Spanish. Plants lacking ABI4 are salt tolerant.
Subcellular Localization:
Nucleus.
Sequence:
MDPLASQHQHNHLEDNNQTLTHNNPQSDSTTDSSTSSAQRKRKGKGGPDNSKFRYRGVRQRSWGKWVAEIREPRKRTRKWLGTFATAEDAARAYDRAAVYLYGSRAQLNLTPSSPSSVSSSSSSVSAASSPSTSSSSTQTLRPLLPRPAAATVGGGANFGPYGIPFNNNIFLNGGTSMLCPSYGFFPQQQQQQNQMVQMGQFQHQQYQNLHSNTNNNKISDIELTDVPVTNSTSFHHEVALGQEQGGSGCNNNSSMEDLNSLAGSVGSSLSITHPPPLVDPVCSMGLDPGYMVGDGSSTIWPFGGEEEYSHNWGSIWDFIDPILGEFY
The following text describes a protein:
Function:
Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members.
Subcellular Localization:
Cell projection, ruffle. Cytoplasmic vesicle.
Sequence:
MAQPEDKAPEVPTEGVRLVPPQVNKADRTPLGVLSTLEPLIRLQRTWGVWHVPELDTQDAEALVGLWPLGSFLVTGRDPSQALVLRSGPLPGEVNTYQIQKIPRGVSLESSNLCMPDLPHLLAFLSASRDVLPRTLLLPPPTLGPRDEHTDPVQIGRVQQDTPGKVLSIVNQLYLETHRGWGREQTPQETEPEAAQRHDPAPRNPAPHGVSWVKGPLSPEVDHPGPAIASLLEEEEEDLEGKEEGREDDPEEEGPEDVLTIHVQSLVRARSSYVARQYRSLRVRIASDSGGPHGSGDPATELLQDVRHLLTDLQDHLAKDSYIRAVFGSRGPGLPKKDEDPGPALETAVCQAVLAPLKPALWTRLRTLRAPELRRLRRRQTALRAGAGPPGAQGPGPEGQSPAPALRSRIHERLAHLHAACAPRRKVALLLEVCRDVYAGLARGENQDPLGADAFLPALTEELIWSPDIGETQLDVEFLMELLDPDELQGEAGYYLTTWFGALHHIAHYQPETDRAPRGLSSEARASLHQWHRRRTLHRKDHPRAQANLPFKEPWAEETVTGTSDN
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Sequence:
MGIDEAGRGPVLGPMVYGCAYCAVAYKEELASLKFADIDRGKTRKAFRELEGGPIDGVKRSLNDISYDSAIGLIKLVLSRGVLLSEVYVDTVGDAEKYQARLSELFPHIKFTVAKKADSLFPIVSAASIAAKVTRDQALKSWVMDEAGCTISRNFGSGYPGDPDTKAWLEQHMDDVFGFPSLVRFSWATCKPLIAEGGVHVYWEADEDDDTALVKKSRSAQTESSGALRHSFFRPPTAAVVTVPTSLPSQGRELQKKNDLHVPPQPLSKRKPGAALASRVFILANKAVALQVRSPGDKSLRLPRELIAILFVLSITTTATATAAITATGTGTHSRKNTGAMLGSTNAIADWGHHLHSFEKK
The following text describes a protein:
Function:
Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate. Involved in the modulation of AMPK and MAPK1/2 signaling pathways.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MYVEPYGLEPVTKIYHIHHPEVYSKLDKCALKPYPEPVPGPSGYKPEPKAVDSEEMYVVPYGLEPVTMISHIHDPEVYFKLDKCALKPYPEPVPGPSGYKPEPKAVDSEEMYVCEPYGLEPVTMISHIHDPEVYFKLDKCALKPDPEPVPGPSGYIPEPKAVDSEEMYVVPYGLEPVTMISHIHDPEVYFKLDKCALKPDPEPVPGPSGYIPEPKAVDSGELCVSDLSGPQPQPQMEEKISLLHLHFTQNISNLDKQQMENRKRWVSICKVFDNLYVGSWKRAMDRVALKRRGITHVLNTLPILANQHALRREQAKLYETMNISYHNVFSRDDDPFNFSCHIYRVAELMHKILSNPENQLLVQDQQGCRHACFFVVPYLMIYHGKTLTKAISHMINRKNIRMSRDLLTQLVVFACHHNQQQQPGLMPEFSSIDINHPQTISQMYLRIVKPSQYWTPVSEVWPNVFIADEKTARNKAKLKKMNITHIVNAVPLSLKEEEWKDYYQKKNITYYNVRSGLGVQGWPNIAQLFSPAAEFLHKALSDTKNKVLLYCSEGLNQSVVLFMAYLMIHQRMKLEEAFEFVLERRRMWISRDYLNQLVMLNLDLAKLRELNECRPCCTDCYEAILRLNLT
The following text describes a protein:
Function:
May be an activator protein for the gylABX operon.
Sequence:
MLRTTNVSFAVPVGKKDDFPLHYDWKEVLNGEKRMVQSLDRAFDVLEALAFADDDLSVSELSEQLDLPLATVHRLLSSLAARGYVTQEASTRRYGPGPRLLEVAARAARSRRFDLIRIARAELVKLTAETGETSNLIVRQGDLAVYQEQIPSPHMVRMFTEIGQRAPLYCTGGGKAILSALPIAELEQYLAGGHFERWTNRTITDPERLRAELMTARERGFALDDEEREEGVCCVAAPIFDRRGQVVGAISLSGPSTRLNRARAEELGPRVREAALACSRQLGFHTTLTGK
The following text describes a protein:
Function:
Probably functions as a manganese efflux pump.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDTLLTSISLALDCFSVSISNSACSNYVRKDALTYATSFGFFQSFMLLSGYSFGLLLESYIRAFDHWIAFLLLLFAGMNMIRGNEVKSAMLLILSIATSIDALSVGIALSLLGLEIITPSLVAGGSSFLLTIAGYCLGSRLRGIGDKSEKVGGLILIGIGVKILMEHTLG
The following text describes a protein:
Function:
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
Subcellular Localization:
Cytoplasm.
Sequence:
MRFLIIHIAVIVLPFVLMIDVKRENSFFLRHSPKRLYKKADYNNMYDKIIKKQQNRIYDVSSQINQDNINGQNISFNLTFPNYDTSIDIEDIKKILPHRYPFLLVDKVIYMQPNKTIIGLKQVSTNEPFFNGHFPQKQIMPGVLQIEALAQLAGILCLKSDDSQKNNLFLFAGVDGVRWKKPVLPGDTLTMQANLISFKSSLGIAKLSGVGYVNGKVVINISEMTFALSK
The following text describes a protein:
Function:
RNA-binding protein required for DNA demethylation and to eluviate siRNA-mediated transcriptional gene silencing (TGS), probably by guiding ROS1. Can bind specifically single stranded G-rich RNAs of 21-, 24- or 26-nt corresponding to promoter sequence of target genes; this interaction directs demethylation of target sequences.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Localized in discrete foci dispersed throughout the nucleus.
Domain:
The RRM domain is required for single stranded RNA binding.
Sequence:
MEEKSSGGGVRLHVGGLGESVGRDDLLKIFSPMGTVDAVEFVRTKGRSFAYIDFSPSSTNSLTKLFSTYNGCVWKGGRLRLEKAKEHYLARLKREWEAASSTSDNTIKAPSDSPPATHLNIFFPRLRKVKPMPLSGTGKHKYSFQRVPVSSSLPRSFCDCEEHSNSSLTPREIHLHDLEAVNVGRQEAEVNVMNSVMNKLFEKNNVDPEEDNEIEADQDNLIINVASSGNDMDSALDMLSRKRKSILNKKTPSEEGYSEGRKGNLTHPSKNRQTISLEETGRQESSQAIRGKKKPSEVVPDKSSDEPSRTKDLEQSIDNISWSQKSSWKSLMANGNSNDFSVSSFLPGVGSSKAVQPAPRNTDLAGLPSRENLKKKTKRKRVTSTIMAEDLPVSDDIKRDDSDTMADDIERDDSDAVEYYTACESMADDTASDSVAERDDSDAVEDDTAIDSMADDPASDSVAESDDGDAVENDTAIDSMADDTVSNSMAESDDGDNVEDDTAIDSMCDDTANDDVGSDDSGSLADTVSDTSVEAVPLEFVANTEGDSVDGKSNVEKHENVAEDLNAEKESLVVKENVVDEEEAGKGPLKASNKSTGGSSWLQKASWTQLVSDKNTSSFSITQLFPDLTSDKGEAAGVINNVGNQFSNSNQTASAMKQTDYASSSGGFVAAGVPVDSTPVRSLDENRQRLNGKNVSEGAKLGAKKKIIKRKVGSGDTCTFMRSSTSLKEWAKAKKALSEPRRKKNSEE
The following text describes a protein:
Function:
Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.
Subcellular Localization:
Cytoplasm.
Sequence:
MKDPSFGTTTHSLTSGSDVILSSQFSPDEEPFAEYLWMEHEEEFNRQSLLIKNSSEDPKATVTDRGKPGSVFISSCVTEVLDQDLVEEELWEEEFIECCFQEMLEEEEQWEWFIPSRDLPATSVSQLQEQIGLLVLDVDVHPNADILDSVKSSILNPNAKEFTPGIQKHAM
The following text describes a protein:
Function:
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Sequence:
MASITINHSFSRNPNISFHPQNPLIQTQALFNFKPSISKCSPIIHCAIRRRPEYTPSHIPDPNYIRIFDTTLRDGEQSPGATMTTKEKLDVARQLAKLGVDIIEAGFPASSEADLEAVKLIAKEVGNGVNEEGHVPVICGLARCNKRDIDKAWEAVKYAKKPRIHTFIATSEIHMKFKLKMSRDEVVEKARSMVAYARSIGCEDVEFSPEDAGRSDPEFLYHILGEVIKAGATTLNIPDTVGYTVPSEFGKLIADIKANTPGIGDVIISTHCQNDLGLSTANTLAGACAGARQVEVTINGIGERAGNASLEEVVMALKCRGEQVLGGLYTGINTQHILMSSKMVEEYTGLHVQPHKAIVGANAFAHESGIHQDGMLKHKDTYEIISPEDIGLNRVNESGIVLGKLSGRHALQAKMLELGYDIEGKELEDLFWRFKSVAEKKKKITDDDLIALMSDEVFQPQFVWQLENVQVTCGSLGLSTATVKLIDADGQEHVSCSVGTGPVDAAYKAVDLIVKVPVALLEYSLNAVTEGIDAIASTRVLIRGENGHTSTHALTGETVHRSFSGTGADMDIVISSVRAYIGALNKMLSFRKLVSKHSKPEGSAVV
The following text describes a protein:
Function:
Serine protease of trypsin-like cleavage specificity. Synthesized in a zymogen form, proacrosin and stored in the acrosome (By similarity).
Miscellaneous:
MISCELLANEOUS: On the 2D-gel the determined pI of this protein is: 6.4.
Sequence:
MALLLPLAVLLAACRPGHGFSGGCDTCGLRPVAYHYGGMRVVGGTEALHGSWPWIVSIQNPRFAGTGHMCGGSLITPQWVLSAAHCFGRPNYILQSRVVIGANDLTQLGQEVEVRSIRRAILHEYFNNKTMINDIALLELDRPVHCSYYIQLACVPDPSLRVSELTDCYVSGWGHMGMRSAAPTQTAEVLQEAKVHLLDLNLCNSSHWYDGVLHSHNLCAGYPQGGIDTCQGDSGGPLMCRDSSADYFWLVGVTSWGRGCGRAFRPGIYTSTQHFYNWILLQVRAAAHPTSRTWSHYMSTSSYHHGPNAVPTQPSVSDSCPFPAQKLREFFTGVQNLLQSLWGSKA
The following text describes a protein:
Function:
Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSQENVSDKVRNIQKQIGHNIKFGQRPPSLRKSEGDEGSSDEEEVPQSPLRVLAQVENEPPETSAKEKSVSHDTVQHRTPVKSPRTKRPPPPGTIESINLDAVPQSVPRLDNTAAKHKLSVKPKNQRVSRKHRRFTQEFHEDDFSEIQEEFEKDEEVFDSSREDYGIIHGSKEDYEPTEKSQRQRFHEEEKEHLEIKKREQEEERKMEKHRRMIEEQRLEEEKRRRQEEERLQKVEEERKQREEEERKKREEEERRREEEERRLRHEEERKRQEEEERMKKEEEERKRAEEERRQQELLAERLRLEEERKREQEERRRKEEEEAEKRRIQELQEKRLREEEHRIREEERCRQEEAERKRLEEEERKRQLQEEKAGSTDPEWKRKAEELRWREMEERQRPFTFKVSSGEKQILFQKVNLTPVTPATGQQGETTAETWEGAKASSPGGPDSPTLSSSLYVPHTAILVTGAQLCGTAVNLDQIKDTACKSLLGLSEGKKAMGTPPSKSKTSPDRKSGKTKSVFESSLSTDQSNAAVLAEWASIRSKIFKGAEEGKYPEYTDQSRRPTSEDLNTVPFSHTNLRKTMSASAKFSITPARKKFADSNRNSEIFGQEEGVKTESAFTETSPVQKELPSLGTKVQSRGSKLVRIADEECMFAKDLPSFLVPSPPHGSPKSQRSESGSPIQAESEDSDTKDEDGEQKAQGGDEQPSPFGIKLRRTNYSLRFHNEQSAEKKKKRYSAGDSFEGVPVPLTAIDQDSDNSTLSEKSSPISPQQENIEFQTTVAPSKESRSKFSRSTLPLARTEGDNMSPKPPLYQKPATSPKPSEGATPLLSPLPKPGRRTSGDTISQRTGEAEQVATEQGSDHKGGVTASGPSQKSGQGEEDVKEKKSFFPSISIPWREKTDRRTELIKKEKPSLQARHSLDSSRSQDKETGPLWITLALQKQKGFREQQQNREERRNQREAKLAEKQARDRESAGSSPTEDKGNGSSSIISKHQTADENKRPDTLLARFERRDNLKKANTLPSSVTVEITDSTPSPPATKDVTKRFPPGDTTQVSTEPAWLALAKRKAKAWSDCPQIIK
The following text describes a protein:
Function:
Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. Involved in splicing pre-mRNA of the A1 cistron and other genes that are important for cell growth (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSIEFVGWLNTYYVGIDQSSYEASKLPGIRNVKGGIHLFTWSPTYPAGLISGVFAMVHEDMKYSIDFDSKSETASLQKLDVLYDENFYPFESTKDWDLLTKFITVQDLQRIFATEGEFFYLDTSTYVNADLVSQDPEFSKPSRDDKLLNFAEFNLRRSWSPSATGPERSKQAIDKSFLFQRLVQSVWNDNPISALAELSISFLSYSILSHYGALEHWKNMLSLLLQSYELAETEPEFYASFLELFKLQLSSLSESDLETSAIFEKGVLLSCLDSLSERKVDGSFGSLVNEAIENLLKTISELLNSHEEQAGLMQKGDLYSAADYEAEVHETGDYVIDVSTEEDPIH
The following text describes a protein:
Function:
Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes; In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.
Sequence:
MSDHAKSSLDQPVLENVDVSTGSLSTPSIPNNDATSSPLKKKYRAPSPPRWRFVKDAKSTTGYSSLAAGKVVDGKSADELGAKYNPPVINYYIQKDKERQVGKLLIEESTPVEEVLPTGEFPGLPKSAVPEEPCKQWREWDPYYQIERHPAERNVRNDEPGVWKERVFEEDEPPVPKDIEVGKLPKHGHDSLTKDFTGTYSLHKAKQEDTACDHQTISILEPQDKEKEQDVIPPPPSSNIGIDSNGGKDSSATQHRTRDKKKIVILLMLLILFAATLIGTLVEKKKTPPNEIESRVDSQSLLQEGNDNVVGGAIAWTNSTTSIPSTTPSLSRYVISVTNKPSALSSTEPSVAASTVPSVSSSFPSNKPSSYESTMTFLPSLIPFVGGCPKAFIPLSYYPIGTEVVVSSEGIVYECISYSCGSYGFQPGSLSTSNLWREGWKVVGSCIDSVQTSTPTHRQTMSFLESPSASPSSLSSSHPSSAPIPSPESQSPTHHPITFAGACPMKFVPLSYYPIGTHVSRDNVIYECISFSCGTYGFEPGSSDLWIEGWKVIGSCIVTITPSSMPSNTLSEVPSVAVSSKSSIMESSSPSAQSSHGVPSLQPSIDEPPSRVPTSSPSLKFTSTPSMSGSSLPRNAVSMSPSEVPSFHASDAPSLFPSLKTSQPSTHPSSSPVTPNPTQRPSSRPVTSSPSPSPSASPLSPTATPSLSPILSPTIPPSIEPIISNPVPTPLPSREQSQPTNMPGVVQEVTLTESPVSSEACPLSGDFSLCFAIDMSGSVCNNGRGECLGCSPLDTCNSVGVKKTMCCSNFLSLMEFTKDVTTSFNEVATDHDFSVVHFATKVNTAIGLVSSRQALKVLNQLIYTGGMTNLASGIASGQETFSSTSGTSKRKNMILLITDGKLFIVYNGKRCSMYQPSLPSYNPEGNAHEAATNAKSKGTVIVPVLMEAASDNAQSLMFMQKISSNGNVYVSDFKGLNDLKDTILSEISCGAVKEVNTLELSSEHVFN
The following text describes a protein:
Function:
[Pre-protein VI]: During virus assembly, promotes hexon trimers nuclear import through nuclear pore complexes via an importin alpha/beta-dependent mechanism. By analogy to herpesviruses capsid assembly, might act as a chaperone to promote the formation of the icosahedral capsid; [Endosome lysis protein]: Structural component of the virion that provides increased stability to the particle shell through its interaction with the core-capsid bridging protein and the hexon-linking protein VIII. Fibers shedding during virus entry into host cell allows the endosome lysis protein to be exposed as a membrane-lytic peptide (By similarity). Exhibits pH-independent membrane fragmentation activity and probably mediates viral rapid escape from host endosome via organellar membrane lysis. It is not clear if it then remains partially associated with the capsid and involved in the intracellular microtubule-dependent transport of capsid to the nucleus, or if it is lost during endosomal penetration; [Protease cofactor]: Cofactor that activates the viral protease. Binds to viral protease in a 1:1 ratio.
Miscellaneous:
MISCELLANEOUS: All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
Subcellular Localization:
[Pre-protein VI]: Host nucleus. Host cytoplasm. Note=Shuttles between host cytoplasm and nucleus; [Endosome lysis protein]: Virion. Note=Associates with the base of each peripentonal hexon on the capsid interior. Present in around 360 copies per virion.
Domain:
N-terminal amphipathic alpha-helix domain is essential for the membrane lytic activity; Late-budding domains (L domains) are short sequence motifs essential for viral particle release. They can occur individually or in close proximity within structural proteins. They interacts with sorting cellular proteins of the multivesicular body (MVB) pathway. Most of these proteins are class E vacuolar protein sorting factors belonging to ESCRT-I, ESCRT-II or ESCRT-III complexes. Minor capsid protein 6 contains one L domain: a PPXY motif which binds to the WW domains of HECT (homologous to E6-AP C-terminus) E3 ubiquitin ligases, like NEDD4. In adenoviruses, this motif seems to play a role in microtubule-dependent intracellular trafficking toward the nucleus during virus entry into host cell and in suppression of DAXX-mediated repression of the immediate early E1A promoter.
Sequence:
MEDINFASLAPRHGSRPFMGNWQDIGTSNMSGGAFSWGSLWSGIKNFGSTVKNYGSKAWNSSTGQMLRDKLKEQNFQQKVVDGLASGISGVVDLANQAVQNKINSKLDPRPPVEEPPPAVETVSPEGRGEKRPRPDREETLVTQIDEPPSYEEALKQGLPTTRPIAPMATGVLGQHTPVTLDLPPPADTQQKPVLPGPTAVVVTRPSRASLRRAASGPRSLRPVASGNWQSTLNSIVGLGVQSLKRRRCF
The following text describes a protein:
Function:
Binds unprenylated Rab proteins, presents it to the catalytic component B, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab to a protein acceptor (By similarity).
Subcellular Localization:
Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, spindle pole. Note=Coordinated with the cell cycle, located around nuclei during prophase and telophase. Located to spindle poles during metaphase.
Sequence:
MLDDLPEQFDLVVIGTGFTESCIAAAGSRIGKSVLHLDSNEYYGDVWSSFSMDALCARLDQEVEPHSALRNARYTWHSMEKESETDAQSWNRDSVLAKSRRFSLDLCPRILYAAGELVQLLIKSNICRYAEFRAVDHVCMRHNGEIVSVPCSRSDVFNTKTLTIVEKRLLMKFLTACNDYGEDKCNEDSLEFRGRTFLEYLQAQRVTEKISSCVMQAIAMCGPSTSFEEGMQRTQRFLGSLGRYGNTPFLFPMYGCGELPQCFCRLCAVYGGIYCLKRAVDDIALDSNSNEFLLSSAGKTLRAKNVVSAPGYTPVSKGIELKPHISRGLFISSSPLGNEELNKGGGGVNLLRLLDNEGGREAFLIQLSHYTGACPEGLYIFHLTTPALSEDPASDLAIFTSQLFDQSDAQIIFSSYFTIAAQSSKSPAAEHIYYTDPPTYELDYDAAIANARDIFGKMFPDADFLPRAPDPEEIVVDGEDPSALNEHTLPEDLRAQLHDMQQATQEMDIQE
The following text describes a protein:
Function:
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MVLSMMLCFILGCSMANTEDTLAASQFCAFNGSTRSFVCLGNKVLEIPRRIPTNTTFVEIKLTQISVFRRAALSELHELKRIVVSENGALERIEALAFFNLTELEEITITKSKNLVMHKDAFWRLPKLRYLTISNTGLKILPDFSKINSAALEFLFDLQDNMHIERIPSNAFLGLTNATITELRLTKNGIREIDSHAFNGTKIGKLFLMGNQQLNHIHSYAFKGAEGPVVLDISRTAVHTLPESMLKTLKLLMAVSVYSLRKLPSLELFTELTQANLTYPSHCCAFKNFKKHKSVKNQMCNVTGAHEEPDFFNFFNDHCKDVIEVTCYPTPDAFNPCEDIMGFTFLRVLIWFISVLAIVGNTVVLLVLLTSRYKLTVPRFLMCHLAFADLCMGIYLLLIAAVDIHTQSRYYNYGIDWQTGAGCHVAGFFTVFSSELSVYTLTAITLERWHTITYAMQLERQMRLRHACLVMATGWLFSLLAALMPMFGVSSYSKTSICLPMDVETLLSQGYVVLLLLLNAAAFLVVCVCYTLIYLTVRNPAFVPANADMRIAKRMAVLIFTDFLCMAPISFFAISAAFKLPLITASHAKVLLVLFYPINSCSNPFLYAFFTKTFKRDFFILTSRFGCFKRRAHIYCTEISSGQNGAVVPSPKTSDGTLYSLVHIAQVH
The following text describes a protein:
Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLVNSTAVSLASVAYITVEILIGLCAIVGNVLVIWVVKLNPSLKTTTFYFIVSLALADIAVGVLVMPLAIVVSLGVTIHFYSCLLMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYRRVTTQRRIWLALGLCWLVSFLVGLTPMFGWNVKLTSEYHRNLTFLSCQFRSVMRMDYMVYFSFFTWIFIPLVVMCAIYLDIFYVIRHKLNHNFSGSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFKGEVPEVVLYLGILLSHANSMMNPIVYAYKIKKFKETYILILKACVICQPSNSLDPSTKKPSE