lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a major role in controlling sexual phenotype. Terminal global regulator in a well-characterized cascade of sex-determining genes. Promotes female development. Interacts with tra-2 to promote spermatogenesis. Promotes spermatogenesis through the Tip60 HAT complex and by regulating the expression of genes, such as fog-3, required for male development (By similarity). Association with chromatin and at the fog-3 promoter requires wdr-5.1, and may also require wdr-5.2. With trr-1, activates the fog-3 gene to determine sperm/oocyte cell fate (By similarity). In hermaphrodites, binds to an intronic regulatory site in the ceh-30 gene, preventing ceh-30 transcription and thereby preventing survival of the CEM (cephalic male) sensory neurons. Represses the expression of the transcription factor dmd-3 in hermaphrodites to govern the timing and extent of male tail tip morphogenesis. Plays a role in controlling the sex-specific differentiation of PHC sensory neurons and represses the development of male-specific morphological features.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localization with chromatin in the nucleus in part depends on normal function of wdr-5.1.
Domain:
Only isoform a (Tra-1L), is thought to bind DNA. Zinc fingers 3, 4 and 5 are the most important for DNA binding; removal of finger 5 almost abolishes DNA binding and prevents the selection of binding sites.
Sequence:
MMAPSTEDPDTVVEAQRRGSFSKKKNANGWNKVELVDQCAKQMGSEDKQPGGGDVKTENDPSKNGLGSATSNFIQSSVPPSHQTLSNPLQLSPPAEASVAQQSGASQVFPTFQAALGASSDELLQPNATSSSTSSSASTSSIVPVVKFTNQTAPNGSTVATSVGQNVRLTINGKRVGRPPGTFKRPQNNAANSSNSGNDSDMMGDHDLTCRWKSCNSSFQTLKALVDHVQESHVQSTEQEHHAWRCEWEGCDRNETFKALYMLIVHVRRHTGEKPNKCEYPGCGKEYSRLENLKTHRRTHTGEKPYKCEFADCEKAFSNASDRAKHQNRTHSNLKPYSCQIPQCTKSYTDPSSLRKHIKAVHGDDEYEKAKKSRPANYSNRRRPDHRLAPPTGAMSHPYLATPNSGASVVAHSSVHQQNFINMALAQHHHNAQRAQQLMAATGNVMPMMDPASAAAAAQAQAHHQAQAQMLQTHMMQQAQIQAAAQMQAQVQHQAAMQAHAMQQAQMVLQNNLLGAQSLLSPFSPLLPPSRAPNVMAMLQTPPTPTSVAPMFDIMTSRAPMAPVVSAPTAPAPLVPAPVPASPVFDELREQMREVEPLQQQQQQEPMDQDLQDIRVDGDSDDEDEEEPRTPSGALLLPRGGNNGDGGFGGSGSSRASSGSGTMELSAAPISQNGSRASGSGERGMRSFLIADILQLAADFQNERLLSDVLDLAIFDTRDVRSLHNIYQVYIRAHKAIPITRRPLDWNETHQLHNLYHDPRFNRAEHQDSPAIRDRDTRFWRTIAEANTMRQRQIEPVPLDDDDEGYFDEMVHRVQNGRLNEQFMEGFESDDDDGFEDEDDVPGLGIAVYRGRRRVRREALKQANLDIQEAETAGRNVGGFGDEEDRNNRGHDQDRSFLDHYYPPMVVVVETESPQIVRDQEMMRQFEEAKKNVETDEIKKRAEAMQFGTSSSHHHTKTLLIQRALFDKTSSVRRSLLQFITISVDQEELRQSCHATSAPQGAHVVHNVVDEFDSIMRAQEDSNNRILLSLDIPAPSAVTGVSGSITHADNSALQLQQEQPTSSFSSWFPEDDPIYALPPPPPPPAPPRRRRSADNKDDSENIPKKPRHQF
The following text describes a protein:
Function:
Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MSEEKCPVDHESRKVWARKLESSTENAASGTAQPKECPVDHTKMKKPEVAQTETKAAAEACPVDHETRDVWVKRQNVASHGLAASVDVEPYGNAALSEPNTGLDQQREISTIPRAGSDSNWVYPSQQQFFNAMKRKQWDPQAEDMQSIVPIHNAVNERAWYEIQRWEGQMADKCGGPKLVSFQGDSKKLTPKARFNNWFLGYQKPFDRHDWTVDRCGTKIDYVIDFYEGKQLPGMIGMPSFYLDVRPKVNSLEGIRMRIANIFGFK
The following text describes a protein:
Function:
Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MRQNVRELALDGLIQVEKSGAYSNLLLNNLIEKSAIDRKDIGLLTEIVYGTIQRRDTLDYYLQPFLKKKVEAWVRVLLRLSLYQMIYLDRVPERAAIHEAVEIAKRRGHKGIAGMVNGVLRSIQREGVPSVDEIKDPVERLAITTSHPVWLVQEWTSEYGLETAEKMCEVNMLPPVPTARVNVDKVTVEEAIELLASEGIEAKLGDLSDDAIQIERGNVAHTEAFKKGFLSIQDESSMLVARALEPNTGDAVLDSCAAPGGKTTHIAERLKGTGKVMSLDLHAHKVRLIKQQAERLGLENVETKALDARKVQEHFANETFDKILVDAPCSGFGVIRRKPDIKLGKDKGDSERLSTIQIAILEKIAPLLKQGGRLVYSTCTIEKIENEQVIEKFLQEHPEFEWDTTLKERMPEKLTPYIDEGQVQILPHYFATDGFYIACLRKKV
The following text describes a protein:
Function:
Histone methyltransferase that trimethylates 'Lys-20' of histone H4 to form H4K20me3.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MPPKANQLKKERLTLAQLCSYDDILTDALVDQVYYWTNIRKNRVAYHSSRGVREEDVTKILQNSVIIEKNTTKAESQLLALPGLNKFQQSLKSEKEKEDFRRHLKKYINIYLPDCPFEVSSTNRYTVVTHEAAIVARREIRKGEVVKYLCGIQVVMTPEEEAHINNSRRDFSIVMSSRNKAASLFLGPARFANHDCGANARLMTTGSAGMEIIAVRDIEIGEEITVTYGDSYFGEDNCECLCKTCEDNRENGWAQDTDDSNETIPKLSIEHEPTPLDTPGYSLRRRRRLPSSVSGSRSESMTPDVNLRPQVRKLPPRSRRSASSARNGRSFAMESPSSESTLPGSNVDEANDDNLLSLAKSLKRVPSGDDSAAATPKRRRVSQSIERSPLRLLRGLDESSPSETMKRPKNQLIVKVEEFTPTSFYGNISSTALPSSASESRRASITSSPSGEGTGETDATSVDEETIVVRDEKPASVGPKAKRQGYVKRGNHGGRRRGPLWEKEKLEKAKQSNKVSSVMQRAASAPREAVLVSPNTSRQHPALQDDADSSALSDLGSDMEIDDSTMTISKKLPQPKIRRRRRGVVPPPTTDLDHAPNVRIPGDYVLTHALLAEPASAWINCKICEEPFVQKDAYFTRSSCPRCERHSKLYGYMWPKTDKEGKHDEEERVLDHRTVHRFIKSSEEKDIRRRIGRGSTGSREVTKEASATPVVSAKGDGNKKPKGGLLKVYGRKSERTRRDRFTLDEVFALVFDIVLILYIRGRMYECNYCGKEWSGLVVYCVECRVERREKREERREKREERREKREERREKREERREKREERREKREERREKREERRDDICD
The following text describes a protein:
Function:
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The PAL motif is required for normal active site conformation.
Sequence:
MAQNTKPTSILDSLGEEIIRIIAPVSICMFMVVILVSVLDSSSSSSTSASVNSIATIAYAETNSDSSWDKFVGALLNSLVFVAVVTVVTFILVLLFYLRCTKFLKLYMGFSAFVVLGFMGGEIALFLIEDFSIPVDCITFVVALFNFAVVGVLAVFMSKMAILVTQAYLVVIGMLVAYWFTQLPEWTTWVLLVAMALYDLAAVLLPVGPLRLLVELAISRDEDIPALVYEARPVTCNGSGAEGRVAQRRVWRDRGSENSDHESNNNPNANSVFVENVDSGSNSTSNASVVPDSSTESNTLVSGHNDATLVRAEEGWVPERDAELSAPLIDPRMNIQPQQSELEGIGLGSSGAIKLGLGDFIFYSVLVGRAAMYDFMTVYACYLAIIAGLGITLALLALYQKALPALPVSIALGVLFYVLTRFLLEAFVVECSLNLLMF
The following text describes a protein:
Function:
Could act as a receptor for an unknown ligand.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MCADATHPRRACWCGAGGVAGCVRQQHAYRCSRLLAGVLLIVGALTLAVSTAPTAWAAGANVSPDEPVYLLNAMYSLSDYSWKHAKALWLGIDSALHAVGYTAASGRPIKIIEPGPTDDRSDIVAVVMKALKDYPTLLGVIGPYSDTRLGALMSSPEIQNSGLMFLGPFTGSSAMRVWNENLYFMRAEPRLEIMAMAKHIANTFRARRTAFTYVTGEWFGSFEHKSLVELMASLSLDPPAVYSAPYSTSTAVNMTAFDAMADTHPQVIIVWGIPAGQVVELLQAVLTDPRTSSAYIMPSFALQQMTFQVYYDLAMAGKLTPVDGQIISSATSFPLTEPASVHLKVFRAQMGEYMVKTGRVDPSLWADEAKAVQKYGPWEHEASSDSAAYVNNFFNEHPCVTQLMIAGWISGSLIAQTLAEENRVVNRMAYRQYMFSQQRYIVGEDFVLGDYGGPCNGVAEFLGAVCYCNQGGHSAVLSRLDKAVWTVITESGVSFTQKSCYSDSTTLPRPLNFLTLIFVGHPLLAQVGLNVNTSIPALFAYLKYSASPVNGIALNVTDTTPQALHDAVTTNYTTDVVVGMTVKGMNVDEYLVLSPLHPRPHLVEPLRNYMYLMPTLEQQMFVLYAKLSAVRDVTPIDSGVHVVLHDYASDEVANITAMLRKSAATFDYDNPSVTAVPSTKTVGSALARGRINVVLAVTAADVAGIVDFLVEEKTSIVVVVFDDLVIQYSTLVTALKSKPASVQARVITFTNLPLWSDTSESAHAASRLLTVFHGALPDPSQHTPGFLSAVIAGSFSASMRRLADSVRSTSLTDMVYREGSVTTTGVPFGKFQWGCTTTPTDRLCVYQNYGAQGIVMLSVQRMLDPTVPQLSSPMTPTMEYRPRKKLDKLTSSERNGLIAGLVMFTVILLAVVGLALYCCMDSRNNDAAPKDGDEPVTLLFTDIESSTALWAALPQLMADAIAAHHRVIRQLLKKYGGYEVKTIGDSFMIACRSAHSAVSLACEIQTKLLKHDWGTEALDSAYREFELARVDTLDDYVPPTARLSEEEYAALWRGLRVRVGIHTGLTDIRYDEVTKGYDYYGDTPNMAARTEAVANGGQVVATEATWWALSNDERAGTAHTAMGPQGLRGVPFAVEMFQLNAVPGRRHAALRTEIEAMLPEGTATETASSAAGALLSSAGTINGPAAGIAFVLTSCFAPYPAAQRVRELQPLLSKWGVGAPPRSRLVSEEDYCQGLMNRLAVRIATVSQARQRMGSNEAGVSGDIQNLISSGLLNPLLGEGSFISDGARARHSGVIAVPPTAEPSAMRGWRVLRKIPERPTACNVRDKQ
The following text describes a protein:
Function:
Responsible for the transport of sucrose into the cell, with the concomitant uptake of protons (symport system). May also transport other glucosides.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAGKSGESVSISVPYRNLRKDVEVEMVSTKHQNDSASSSPLNRSDGAAVAKDCSLVTLVLSCTVAAGVQFGWALQLSLLTPYIQTLGISHAFSSFIWLCGPITGLVVQPCVGIWSDKCTSKYGRRRPFILVGSLMISIAVIIIGFSADIGYLLGDTKEHCSTFKGTRTRAAFVFIIGFWLLDLANNTVQGPARALLADLSGPDQRNTANAVFCLWMAIGNILGFSAGASGRWQEWFPFLTSTACCAACGNLKAAFLLAVVFLTICTLVTIYFAEEIPLASTRTSGLEHSKSNDSPGSVLVNLLTSLRQLPPDMHSVLIVMALTWLSWFPFFLFDTDWMGREVYHGNPTGDSLLVKLYGQGVREGAFGLLLNSVVLGFSSFLIEPMCQRMGARAVWALSNFTVFACMAGTAVISLMSLRDNSEGNEHILPNETTRTAAVIVFALLGFPLAITYSVPFSVTAEVTADSGGGQGLAIGVLNLAIMIVSIGAGPWDALFGGGNLPAFVLASVAAFAAGVIALRSLPTLSSSFKSTGFHIG
The following text describes a protein:
Function:
Pi subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces. When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Pi-containing GABAARs are mostly located in peripheral tissues. In the uterus, pi subunits modulate uterus contraction by altering the sensitivity of GABAARs to pregnanolone. In the lungs, pi-containing GABAARs contribute to pulmonary fluid transport via luminal secretion of chloride.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein.
Sequence:
MKLIQNRLGRSHRRPWARGERQSIGDSYFGLSLRECLINMKYSLYLTFMCLSLFTPRICVQGNQFNIETSRSDKLSLPGFENLTAGYNKFLRPNFGGEPVQIALTMDIASISSISESNMDYTATIYLRQRWTDQRLVFEGNKSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLESWGYDGNDVEFSWLRGNDSVRGLENLRLAQYTIQRYFTLVTRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTSKEVEEVNITNIINSSISSFKRKISFASIEISGDNVDYSDLTMKTSDKFKLVFRDKMGRIVDYFTIQNPSNVDRYSKLLFPLIFMLANVFYWAYYMYF
The following text describes a protein:
Function:
May play a role in male fertility. May act as a retinoid carrier protein within the epididymis.
Subcellular Localization:
Secreted.
Sequence:
MEARLLSNVCGFFLVFLLQAESTRVELVPEKIAGFWKEVAVASDQKLVLKAQRRVEGLFLTFSGGNVTVKAVYNSSGSCVTESSLGSERDTVGEFAFPGNREIHVLDTDYERYTILKLTLLWQGRNFHVLKYFTRSLENEDEPGFWLFREMTADQGLYMLARHGRCAELLKEGLV
The following text describes a protein:
Function:
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.
Subcellular Localization:
Cytoplasm.
Sequence:
MEEINNVEVVPCTQSDYLKPFRVHYNQNGTKKTWDFMRTHDSVSVLIFNTTSHCFVLVKQFRPAVYMCEWEKAKKQPNEKTEEGGAAEAAEAATAAESQEGESSSQGPPFSAGVTYELCAGLVDKPGLSLEEIARQEVLEECGYDVPASKLKRITSYRSGVGVTGSKQTMFYAEVSDDNCVSAGGGEPHEGEFIEVVKIPLHEAMLFAYNERIPKTMGVIFSFIWFHNNMAPKYKISTNV
The following text describes a protein:
Function:
Zinc-binding protein that binds only one zinc ion. Is required for swarming and biofilm formation.
Domain:
Contains four C(P)XCG motifs, suggesting the presence of two zinc binding pockets (ZBPs), but only ZBP2 (comprised of C(P)XCG motifs 2 and 4) is occupied by zinc. All four C(P)XCG motifs are essential for protein stability, folding, and functionality.
Sequence:
MSESEQRHAHQCVSCGINIAGMSAATFKCPDCGQEISRCSKCRKQSNLYECPDCGFMGP
The following text describes a protein:
Function:
Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function.
Sequence:
MGSGGDSLLGGRGSLPLLLLLIMGGMAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQSAELGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVPPPAENHNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLEIATHMPGSYCVQVAAVTGAGAGEPSRPVCLLLEQAMERATQEPSEHGPWTLEQLRATLKRPEVIATCGVALWLLLLGTAVCIHRRRRARVHLGPGLYRYTSEDAILKHRMDHSDSQWLADTWRSTSGSRDLSSSSSLSSRLGADARDPLDCRRSLLSWDSRSPGVPLLPDTSTFYGSLIAELPSSTPARPSPQVPAVRRLPPQLAQLSSPCSSSDSLCSRRGLSSPRLSLAPAEAWKAKKKQELQHANSSPLLRGSHSLELRACELGNRGSKNLSQSPGAVPQALVAWRALGPKLLSSSNELVTRHLPPAPLFPHETPPTQSQQTQPPVAPQAPSSILLPAAPIPILSPCSPPSPQASSLSGPSPASSRLSSSSLSSLGEDQDSVLTPEEVALCLELSEGEETPRNSVSPMPRAPSPPTTYGYISVPTASEFTDMGRTGGGVGPKGGVLLCPPRPCLTPTPSEGSLANGWGSASEDNAASARASLVSSSDGSFLADAHFARALAVAVDSFGFGLEPREADCVFIDASSPPSPRDEIFLTPNLSLPLWEWRPDWLEDMEVSHTQRLGRGMPPWPPDSQISSQRSQLHCRMPKAGASPVDYS
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
MNVELKAEAYSDEVYAQVTLVPEVQKDNLCFEEEVNIDQIPSRNAAYSFSKILTPSDTSTHGGFSVPKKYADECFPPLDMTLQTPAQEIVAKDLNGFEWRFRHIYRGQPKRHLLTSGWSLFVNAKKLVAGDSCIFVRGESGELRVGIRRAAENLSNISQSSSLISGHSMQLGILTNASNAVGNRTMFLVYYRPWTNPFEFIVHLQTYLKSTLQDYPIGTRVQMQHEVEESLRRLAGTIIGNEDIDSIRWPGSAWRRLKVQWDAIVEDKMHPERVCPWWIEPLESAKEKKQVPALPTKKKGHALLNQRSLPGISGFGKNDVHQNSAGPSSQTRRADGDLQGQDYSGLSPPQPLQRAPSTDIIRPSKVPIRGSRFGKENRNQHPFLKQDPLHKSLGRSMSLTHEDLSITSSNLTSIGSESLGMPSTESRDENDAPFGQPGSSSTFKLFGVNLIDSSPEIPSVNFVDLNKTSSLPSSPPMGVAPGKTCKKCRCVNNRSCTKVLKLGNALGRAVDLARFNGYTELIAELDSMFDFQGTLISGGSGWHVTCLDDEGDMMQLGDYPWQDFLGVVQKMIICPKEGTDNLKPGSSANP
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Sequence:
MDNKKNQHKPVDSFKDLIGSKNDVFLEKEDSKSAKSSDSDPWIDSSSSADDDSDIVNSEWFTDDGPIDARPKYDFEVKPITEPKYDFEVKSIAESKYDFEVKPIRSIEPKFDFEVKSIISAGPKCDFEAKPIESLEPKCDFARENEKNKPVRTPNVLKTYKGAGLLNLGNTCFLNVVLQCFLHTVPLFDLLLHTHVVPCDSFCLICAFKELIGFSLAYEAYDGCSVSPWRLVENLSYFSSGFHKYQQEDAHEFLQCFLNRLESRCSDIVFGGRLVSKVRCCNCGHYSNTYEPLIDVSLEIKDANSLHSALESFTRVEKLDDPEIKYTCERCKVQVSIEKQLMLYDAPSIAIIHLKRFQNDGSVVGKVDKHVSFPLELDLLPYTDNNQTNNEQMKYYLYAVIVHAGSTSSSGHYYCFICAEPNEWYKFDDSTISWVHEDLVLAEEAYIMFYAKRDTLWFSDFVALEVINSSYFHELKKIVDNELKKTVRTSSTPGPPSVIYSLLENNASQDIGVTKRKAPLFPKSPSRPQSTLDQVASENQWQMDPEQETEMMMACSMIKRRVPGPREKHSVVSDVSESNVAADETLQASNPGPTSAINSSDSHELNKIVDKELKETLQRLSTKYTYPTLFSLVLRISLLLKYQPIRSIEPKFDFEVKPISSIEPKFNFEMKPISSIGPKCDFEAKPIESLEPKCDFARENEENKPGWTYNVLKTFKQEDAHEFLQCFLNRLESRCSDVVQQAFGGRLVRKLCCCTCGHYSNTYEPLIEEILEIEYVGSLHSALESFTRVEKLDDTEIKFSLEAINSSYFHELKKIVDNELKKIVQISSTPGPPSAINSSLEKNASQDIGVTERMEPLLPKLPSRSQSTLRKLIINFYLLMNPEQETEIMLACSMIKKRVPGSRDEELMTALHRLGSRGSSMSRKDDGSSIDRRSSRFWLCSFGS
The following text describes a protein:
Function:
Positive, redox-sensitive regulator of sigma-F (SigF) activity. When reduced binds to anti-sigma-F factor RsbW (UsfX) preventing its binding to SigF, thus activating transcription.
Sequence:
MNPTQAGSFTTPVSNALKATIQHHDSAVIIHARGEIDAANEHTWQDLVTKAAAATTAPEPLVVNLNGLDFMGCCAVAVLAHEAERCRRRGVDVRLVSRDRAVARIIHACGYGDVLPVHPTTESALSAT
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MSSTTAVHALTERKPWKAIPVKVGKSAPKFNDLIEFEELSEYDLVGAFDNEPIKPITNLPKKKKNLRKQERLNKLKSLKEPEKVVVDKTTTELPENTTDQNNKDVIEKITTVNNNENNVKAKKRKNKTKPNKKSKKAKLNSGTQIEETNEEENEDILSTVDMSAWQNLYVPETVLKALAELRFTKPMPIQEQCIPVAIRDKRDILGAAETGSGKTLAFGIPLLHHLMEDRDDEHMSDFEDAEPVSKEEIEETQPTKALPALVLTPTRELAIQVKKHLTQVAKHTKLWSTVVVGGMAQQKQIRLLNKEPDIVIATPGRLWELLESGHPYLSTIHKLRYLVIDEADRMLEHGHFEELNKLLEVINLKKSKTVISVSLNLYITIYTQKRQTFIFSATLTTVHFTPNRPNFPTQASSNTKDTKLSKLMKKIGVRNKPFVADLTTKKLTAEKLSEAKIICQPKEKDFYLYYFIKSHPGRTLIFTNSIDCIFHLSGVLDALGCNPLHIHAKMQQRQRLKHLDRFQENPNAIMIASDVAARGLDIPGVKYVIHYQVPRTMETYIHRSGRSARSGEDGLSLLFVSSDEMSFYKRICRSLDKEDGLPLFLINDSYMAAIRKMVTLAREVDSLSHREKKVRLHNDWFSKAAAAMDMDIDDDMLLSTDNRSDKTQLLKSKRQQLSALLKRPIFPKGFSGMDF
The following text describes a protein:
Function:
Transcription factor that is involved in activation of anaerobic genes such as DAN/TIR cell wall mannoprotein genes and YML083c. Appears to bind to anaerobic response elements (AR1) with the consensus sequence 5'-TCGTTYAG-3' present in the promoter regions of DAN/TIR genes. Involved in sterol uptake and regulation of the sterol biosynthesis. Binds to sterol regulatory elements (SRE) with the consensus sequence 5'-TCGTATA-3' present in ERG2 and ERG3 promoters. May be involved in down-regulation of CWP2 during anaerobic adaptation.
Miscellaneous:
MISCELLANEOUS: Present with 752 molecules/cell in log phase SD medium; MISCELLANEOUS: ECM22 and UPC2 (in combination) null mutants are not viable.
Subcellular Localization:
Nucleus.
Sequence:
MSEVGIQNHKKAVTKPRRREKVIELIEVDGKKVSTTSTGKRKFHNKSKNGCDNCKRRRVKCDEGKPACRKCTNMKLECQYTPIHLRKGRGATVVKYVTRKADGSVESDSSVDLPPTIKKEQTPFNDIQSAVKASGSSNDSFPSSASTTKSESEEKSSAPIEDKNNMTPLSMGLQGTINKKDMMNNFFSQNGTIGFGSPERLNSGIDGLLLPPLPSGNMGAFQLQQQQQVQQQSQPQTQAQQASGTPNERYGSFDLAGSPALQSTGMSLSNSLSGMLLCNRIPSGQNYTQQQLQYQLHQQLQLQQHQQVQLQQYQQLRQEQHQQVQQQQQEQLQQYQQHFLQQQQQVLLQQEQQPNDEEGGVQEENSKKVKEGPLQSQTSETTLNSDAATLQADALSQLSKMGLSLKSLSTFPTAGIGGVSYDFQELLGIKFPINNGNSRATKASNAEEALANMQEHHERAAASVKENDGQLSDTKSPAPSNNAQGGSASIMEPQAADAVSTMAPISMIERNMNRNSNISPSTPSAVLNDRQEMQDSISSLGNLTKAALENNEPTISLQTSQTENEDDASRQDMTSKINNEADRSSVSAGTSNIAKLLDLSTKGNLNLIDMKLFHHYCTKVWPTITAAKVSGPEIWRDYIPELAFDYPFLMHALLAFSATHLSRTETGLEQYVSSHRLDALRLLREAVLEISENNTDALVASALILIMDSLANASGNGTVGNQSLNSMSPSAWIFHVKGAATILTAVWPLSERSKFHNIISVDLSDLGDVINPDVGTITELVCFDESIADLYPVGLDSPYLITLAYLDKLHREKNQGDFILRVFTFPALLDKTFLALLMTGDLGAMRIMRSYYKLLRGFATEVKDKVWFLEGVTQVLPQDVDEYSGGGGMHMMLDFLGGGLPSMTTTNFSDFSL
The following text describes a protein:
Function:
May act as receptor for class I MHC antigens. Becomes activated upon coligation of PIRB and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).
Miscellaneous:
MISCELLANEOUS: Belongs to the leukocyte receptor cluster (LRC) present on chromosome 7.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, including PTPN6/SHP-1, resulting in the dephosphorylation of the downstream protein kinases SYK and BTK.
Sequence:
MSCTFTALLRLGLTLSLWIPVLTGSLPKPILRVQPDSVVSRRTKVTFLCEETIGANEYRLYKDGKLYKTVTKNKQKPENKAEFSFSNVDLSNAGQYRCSYSTQYKSSGYSDLLELVVTGHYWTPSLLAQASPVVTSGGYVTLQCESWHNDHKFILTVEGPQKLSWTQDSQYNYSTRKYHALFSVGPVTPNQRWICRCYSYDRNRPYVWSPPSESVELLVSGNLQKPTIKAEPGSVITSKRAMTIWCQGNLDAEVYFLHNEKSQKTQSTQTLQEPGNKGKFFIPSVTLQHAGQYRCYCYGSAGWSQPSDTLELVVTGIYEYYEPRLSVLPSPVVTAGGNMTLHCASDFPYDKFILTKEDKKFGNSLDTEHISSSGQYRALFIIGPTTPTHTGAFRCYGYYKNAPQLWSVPSALQQILISGLSKKPSLLTHQGHILDPGMTLTLQCFSDINYDRFALHKVGGADIMQHSSQQTDTGFSVANFTLGYVSSSTGGQYRCYGAHNLSSEWSASSEPLDILITGQLPLTPSLSVQPNHTVHSGETVSLLCWSMDSVDTFILSKEGSAQQPLRLKSKSHDQQSQAEFSMSAVTSHLSGTYRCYGAQDSSFYLLSSASAPVELTVSGPIETSTPPPTMSMPLGGLHMYLKALIGVSVAFILFLFIFIFILLRRRHRGKFRKDVQKEKDLQLSSGAEEPITRKGELQKRPNPAAATQEESLYASVEDMQTEDGVELNSWTPPEEDPQGETYAQVKPSRLRKAGHVSPSVMSREQLNTEYEQAEEGQGANNQAAESGESQDVTYAQLCSRTLRQGAAASPLSQAGEAPEEPSVYATLAAARPEAVPKDMEQ
The following text describes a protein:
Function:
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MGYKSDQLLIVVSILEGRHFPKRSRHMLVIDAKFDGEQLSTDPVPHLEQPQFATELAWELDRKTLHQHRLQRTPIKLQCFALDTLTSAKESVGYVVLDLRAAQEKKQAPKWYSLLSSKYTKFKPEIQLNISLETDNKPAVDTFKAKEAPPRRSKVPGDLAGLEPKSLVPILNEAEGYHQIGPAEYCKDYFVLSVTIAFATQLEQLIPSTLRLPEPQPEFFFYYSLLGNDVTNEPFTDLINPEFEPERASVRIRSSKEVLCMYLSVQPKLQIHLCCGDQSLGSTDIALTGLLNKASVEIEHHPVVVEGAFILTPPNRAKQNLSAVPLEMSPTIGVSIALQKEIGLQSVHHPKEQPQSVAAEEVPTTPLKKSANLKEGARSPPPPKPLMFSDSPPTKDEATESEAESIKSDFQAEPPLSKPLTRSKSPPLSEPPLSGSHCPTPIQGVSAIAKNTSESSSAQKITVPPAAHHFCFTIDLRSIRNVDVGFPVNCILRYSYPFFGSAAPIMTNPPVEVQKNMEVFLPQSYCAFDFATLPHQIQDTFLRLPLLVELWHKDKMTKDLLIGVTKIQLSNVLSSEKTRFLGPHGDQCWRQTFSERITVTAVEGSKNKVAELSYIITLEDYGLVKVREVVVSESSQSTGQEKGSLPAQTLQSTAPLPEPRETLEYKAALELEMWKEMQEDLFVNQLKKKELVHMQALAEEWKRRDKEREALVKKKVAEYTVLEEQLQKALADLEKRERQLANDEMELKKLKAQMQLDCERSIQERQDSIRRVREDCMHQIELERSKAKQLEEDKLRLQQQVELERKLESTTKSKLHYKQQWGRALKELARLKQREQENAMARLKKQQQELEHMRLRYLAAEEKDVVKTERQELEEIRNELNR
The following text describes a protein:
Function:
Homophilic binding protein that enables kin discrimination in heterogeneous yeast populations by mediating homotypic cell-cell interactions during flocculation, a reversible and asexual process in which cells adhere to form aggregates (flocs).
Domain:
The Flo11 domain contains aromatic residues that form two hydrophobic bands on the surface of the protein that confer homophilic binding. The hydrophobic bands are lined by stretches of acidic residues that may sensitise the protein to environmental pH (By similarity).
Sequence:
MLRGFFTLLIFVAFTAATAVINACPNQKFTFHAQVVNFPQATITVTDPSDNGDGTWDVTINFNADATMSLKSLSELKILSLSKTYFLYSYNLKVDNINNPGSWSQRVTVTPRSVGDYKTCMPQFTIQYDWCSAGVTDWSECQNWKYQGSYDYITGCDNFDQSTGFSQKDAPDYCWDATLPQSSSAVISSAAPSSSAPVVPSAPATPNTPSSPSDPNTINACPNQKFTFHAQVVNFPQATITVTDPSDNGDGTWDVTINFNAVATMSLKSLSELKILSLSKTYFLYSYNLKVDNINNPGSWSQRVTVTPRSVGNYKTCMPQFTIQFDWCSAGVTDQSECQNWKYQGSYDYITGCDNFDQSTGFSQKDAPDYCWDVNVPSSSSAIVSSSAAPSSSSVPAAPSSSSVPVAPQSSSAPAVPSAPATPNTPTDPDTINACPNQKFTFHAQVVNFPQATITVTDPSDNGDGTWDVTINFNAVATMSLKSLSELKILSLSKTYFLYSYNLKVDNINNPGSWSQRVTVTPRSVGNYKTCMPQFTIQYDWCSAGVTDWSECQNWKYQGSYDYITGCDNFDQSTGFSQKDAPDYCWNEPKSSSSQSSATYLTPHNFDVTSGDFSVPASSSVVSSQASSSVVSSQASSSVVSSSSSEVTSETPNDPQNRPPPRTVGPEVSTVTFSSDSASSAISSRTARLSSSAASSGLSSSEVSSSEVSSTLPSSDASSTEASSVVSSDASSAITSEFHPHTLAPKFSLVSSYDFPPSSDSISTESSSQESSVVSSTDGSSVVSSTEVSSKASSTDGSSAISSTEESSKVSSTDVSSSTEESSVVSSTEASSKVSSTEGSSVVSSTEVSSKASSKISSRASSTEGSSKVSSTEVSSKVSSAEVSSTEVSSKVSSTEGSSAVSSTEGSSVVSSDVSSKVSSTEVSSRASSKVSSKVSSTEESSKVSSTEVSSKVSSTDGSSVVSSTEVSSKDSSSTTSEFHPHTLAPKFSLISSYDFPPSSDSISTESSSQESSVVSSTDGSSVVSSTHGSSIVSSTEVSSKVSSTEGSSVVSSTEASSKVSSTEVSSKASSKTSSRVSSTEGSSVVSSTEVSSTASSSTTSEFHPHTLAPKFSLISSYDFPPSSDSISTESSSQESSVVSSTEGSSKVSSKVSSTDGSSVVSSTEGSSKVSSTEASSKASSTEGSSKVSSTEASSKASSTEGSSKVSSTEASSKVSSTKASSKVSSSKVSSTEASVVSSTEGSSKVSSTERSSKVSSTDASSVVSSTDGSSVVVSSTETSSVAYPTDSSSVVSSTEASATTSEFHPHTIAPKFSLITSDEVSSTDGSSVVSSTEGSSKVSSTEGSSKASSTEGSSKVSSTEGSSKASSTEGSSVVSSTEGSSKVSSTEASSKVSSTKVSSTEASVVSSTEGSSKVSSTEASVVSSTEASSVVSSTEASSVASSTEGSSVVSSTEGSSVVSSTEASSVASSTEGSSVVSSTEGSSVVSSTEASSVVSSTEGSSVVSSTEGSSKVSSTEASSVASSTEGSSVVSSTEASSVVSSTDDSSIVSSTETTSTWPHTIAPKFSLVTSSEPSTEQSSVASSTETSNSFTTTFPVDPRILIESSTSSTIFSSSETPISSFARYTNSSIVVSTPQPSEPAFSLPPPGQPVVPAFSSGSSFDASSSTNVDSSSASPSGSFSTDSSSGSLFVSSSDLTSSSTFSSASSTIASSGSSPSPSVPGYSSTDGSSSGVPSGSIPAVPFGASSTDGSSYSVPSGSSPAVPSGSSSTDGSSYSVPSGSSPAVPSGSSSTDGFSSVASESSPADPTGSQYATTSVPSASVTSDVSTSGFTSEQPTPSAPGTTTLTITSCDKSTCTTSYKTTGITVRTTTIGSLVTKFTTYCPLTGVSSTPSPSEGVQTPTTGSPDVPSPSTTTITETTCDETSCTTSYKTTGVTVITTTVGSIVTKYTTYCPLTGTSPSEPLNGVSTGVPHVPAPSTTTITEVSCDDTTCATAYKTTGLTVVTTTIGSVVTEYTTYCPLSGTHSEVVETVSTIAPTASAPSTTTITETSCDESSCTTAYKTTGVTVITTTINEMVTEYTTYCPLSGQSTATTPVGETSTTPAGSKETTISSVYHSGSPVSTESGVVSSPSSSPLITIASTSGGASNVRLSVASLLVLLPLFI