lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Binds to dvl2 and may regulate the degradation of ctnnb1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Seems to activate the canonical Wnt signaling pathway.
Subcellular Localization:
Cytoplasm.
Domain:
The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins.
Sequence:
MNEWSEMLVCRDYCALMMRDRKECDARCCRDGEGERVRARERLDATVAGLTELEYLRQRQELLVRSVLSCPEAAGQDKPCLTVDDSYLNTEEKLLEENILLLRKQLNCLRRRDAGLINQLQELDRQISDLRLDTETSHEHVETDSRPSSGFYDLSDGASGSLSNSSNSVFSECLSSCRSTTCLCTPLDTSLCASEGRLKPADDPGSCAECDCHCEDSSSGTVRRSLSASYSPSPDSSCDGISKFHCDLIAKNGNDVYRYPSPLHAVAVQSPIFIQSMTSHLKDDCNFSKPGEALNDEQKPEQVVGSQTSSWHASQMLPNKKLDSYIYGLLQRRAQPLRTNKPRTSINTDPSKSILRQASLCSRAPASVQAQQWTSDLKPNWQTCLQDASATSTEPSTASPQRQWSAESKGGTPQNGAYLSSSQPQNSYSTTNENTNCLLKKKVSGTSKGQLLSATPKDCPDLGSPKAVSSPKLNKHCFYNVEDNKTGQAMKASPLKRSPKTQTSLSCGKDSEQLAQELVSLGSSSQSQDEGGPLVSAQYIPAQKQNVNLQKGGTKNIKIVKVKNSASSKSRPQVFEHVSETVRDKHRTGSRRTRQVDEVHHLHKSSKKASAKTKRIPASIPEGRILERHTSSSGARSSAQRHHGHHRHHEAVLAKPKYKRNDFHRRPRGLHEIPYEEAYRRAHRRQKREMLSHMYLPSNAHYTSPYAYVGSDSEYSAECASLFHSTILDTSEDERSNYTTNCFGDSESSASEADYVAESSTSSDSEGSAGVNWRQISQAGSGSHGMTSAQAKAFVKIKASHNLKKKILRFRSGSLKLMTTV
The following text describes a protein:
Function:
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Domain:
The C-terminal di-lysine motif may confer endoplasmic reticulum localization.
Sequence:
MFGVRRTRIWEMCSERCLMGNLKLEVLVRQKTNEKEYNLKISQYNKPEVGGRLQADASPCTQEHIEKLVQEINASVEYLFGPRDPRVRGWLMLDSYLPTFFLTLLYLLFIWLGTKYMKNRPAFSLRGHLIVYNLGVTLLSLYMLIELILSSWQGGYNLQCQNLYSAGEADVRVAKVLWWYYFSKAIEFMDTIFFVLRKKNSQITFLHVYHHTTMFNIWWCIMNWIPCGFFGPTLNSFIHFLMYSYYGMSVIPSMHKYLWWKKYLIQAQLVQFLLIITHTLSAAVKPCGFHVGCLMIQTSYVTTLVILFVNFYLKTYKKRPSKSDPNGFPAVTEMKNGDHKELLNASNGILYKKEQ
The following text describes a protein:
Function:
Required for the initiation of mitotic and premeiotic DNA synthesis. Has an additional role in meiotic division.
Sequence:
MAPRSSAVHVAVYSGVEVYECFIKGVSVMRRRRDSWLNATQILKVADFDKPQRTRVLERQVQIGAHEKVQGGYGKYQGTWVPFQRGVDLATKYKVDGIMSPILSLDIDEGKAIAPKKKQTKQKKPSVRGRRGRKPSSLSSSTLHSVNEKQPNSSISPTIESSMNKVNLPGAEEQVSATPLPASPNALLSPNDNTIKPVEELGMLEAPLDKYEESLLDFFLHPEEGRIPSFLYSPPPDFQVNSVIDDDGHTSLHWACSMGHIEMIKLLLRANADIGVCNRLSQTPLMRSVIFTNNYDCQTFGQVLELLQSTIYAVDTNGQSIFHHIVQSTSTPSKVAAAKYYLDCILEKLISIQPFENVVRLVNLQDSNGDTSLLIAARNGAMDCVNSLLSYNANPSIPNRQRRTASEYLLEADKKPHSLLQSNSNASHSAFSFSGISPAIISPSCSSHAFVKAIPSISSKFSQLAEEYESQLREKEEDLIRANRLKQDTLNEISRTYQELTFLQKNNPTYSQSMENLIREAQETYQQLSKRLLIWLEARQIFDLERSLKPHTSLSISFPSDFLKKEDGLSLNNDFKKPACNNVTNSDEYEQLINKLTSLQASRKKDTLYIRKLYEELGIDDTVNSYRRLIAMSCGINPEDLSLEILDAVEEALTREK
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase using S-adenosyl-L-methionine as methyl donor. Mono-di and trimethylates 'Lys-943' of AARS1.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MDQHLHIAQQPLLSGTPQEDGFAGPSVEFDRIESSLRSIQKFVPTDYASYTQEHYQFAGKKIIIQESIENYGTVVWPGATALCQYLEDHTEELNLQDAKILEIGAGAGLVSIVSSLLGAQVTATDLPDVLGNLQYNILKNTLECTAHLPEVRELVWGEDLEQSFPKSTCCYDYVLASDVVYHHYFLDKLLATMVYLSQPGTVVLWANKFRFSADYEFLGKFKQAFDTTLLAEYSESSVKLFKGILKWE
The following text describes a protein:
Function:
Might be efficient in the degradation of transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions.
Subcellular Localization:
Periplasm.
Sequence:
MKRINIVLSGIMLFLTLLLSFGMSWGNKNFTSSQNVSSVQLAPSLAPMLEKVMPSVISINIEGSTVVHTSRLPHQFQPFFGHNSPFCQGNSPFRNSPFCRSNPNSNSMHEKFHALGSGVIINADKAYAVTNNHVVENANKIQVQLSDGRRYEASIIGKDSRSDIALIQLKNAKNLSAIKIADSDTLRVGDYTVAIGNPYGLGETVTSGIISALGRSGLNIEHYENFIQTDAAINRGNSGGALVNLKGELIGINTAILAPDGGNIGIGFAIPGNMVKNLTEQMVKFGQVKRGELGIIGMELNSDLAHVMKINAQKGAFVSQVLPNSSAFHAGIKAGDIIVSLNKKTISSFAALRAEVGSLPVSTKMELGIFRNGITKNVIVELKPSLKNSVSLGDIYTGIEGADLSDCSLNGQKGVKIENIKLNTQASKIGFKKDDIIVEVNQKVINNLNDLKNILDSKPNILVFSVKRGNNSIYLVSE
The following text describes a protein:
Function:
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
Subcellular Localization:
Cytoplasm.
Sequence:
MKQGMKSPAELLTPGRALTLANVAEGAEGLVISDLARAIAARPKKPAVSLAVVCRDGARMQQLERALQFFAPDLPVLTFPAWDCQPYDRVSPHGGILAQRLTTLARLAPLTGSDKPLIVLTTVNAIVQRVPARELVAAQALSVAPGNVVPMDTIIAWLEHNGYNRSSTVREPGEYAVRGGILDLFPAGLDQPVRFDFFGDSLESIRSFDAETQRTLLDMRSLDLVPVSEFQLVTDTIRRFRMGYVAEFGAPERDDALYEAVSEGRRHPGMEHWLPLFQDRMDTLFDYLQGAVIAIEPQAEDAVRERFKQILDYYQARREAMEHPGGGAIYKPLPPDRLYFTEEEWTRRLGDVPLVRLTQFSVPADGTGVVDAGARKGRDFAPERNDTTVNVFESVVSHVMALQAQRKKVVITLWSEGSRDRMTSMLRDHKLAHTTSVNSWRTVQATPRNETMLAVLGLDSGFETDEIALISEQDILGDRLVRPRRASRKLDNFISEVTSLAAGDIVVHVDHGIGRFVGLQTLDVAGAPHDCLELHYAAETKLFLPVENIELLSRYGSDQTTVELDRLGGSGWQTRKAKLKNRIREIADELIKIAAARHLHEAPKLPVQPGLYDEFCARFPYDETEDQLGAIESTLKDLELGRPMDRLICGDVGFGKTEVALRAAFAVALEGKQVAVVVPTTLLARQHARTFTERFKGFPVNVAQASRLIPTKELNQVKKGIADGSVDIVVGTHALLGKAIKFRDLGLVIVDEEQHFGVTHKERLKALRSEVHVLTLSATPIPRTLQLALTGVRELSIIASPPVDRLAVRTFVAPHDPLMIREALLRERYRGGQAFYVVPRIDDLAEVKDFLDKNVPEMKVAVAHGQMPPAVIEDIMTAFYDGKFDILLSTTIVESGLDIPNANTLIVHRADMFGLAQLYQLRGRVGRSKLRAYALFTLPAQQKITTQAERRLIVLQSLETLGAGFQLASHDLDIRGAGNLLGEEQSGHIKEVGFELYQSMLEEAIVNLKAGVSEPAADRWSPSITIGMPVLIPEDYVSDLSVRLSLYRRLADLDTEEEIENFGAEMRDRFGVLPDEVRYLFKVAAIKAFCRRANVEKIDAGPKGAVIAFRDNSFAYPDRLVTFIRSHGQAAKVRPDMKVVFLQDWETPEDRLAGTTEIMRQLAQLAQAKKAA
The following text describes a protein:
Function:
Catalyzes ATP-dependent phosphorylation of D-ribulose at C-5 to form D-ribulose 5-phosphate. Postulated to function in a metabolite repair mechanism by preventing toxic accumulation of free D-ribulose formed by non-specific phosphatase activities. Alternatively, may play a role in regulating D-ribulose 5-phosphate recycling in the pentose phosphate pathway. Can phosphorylate ribitol with low efficiency.
Sequence:
MDIQTHVLTHMQQVLPLAEPLPSPVHGRGTMMSGGDQEPDHYYVGIDVGTGSVRAALVDQRGVLLAFAEQPIKKWEPQFNHHEQSSEDIWAACCRVTKEIVQGIDAHRIRGLGFDATCSLVVLDKEFHPLPVNREGDSSRNIIMWLDHRAVSQVHRINETKHSVLQYVGGVMSVEMQAPKLLWLKENLREICWDKAGHFFDLPDFLSWKATGVTARSLCSLVCKWTYSAEKGWDDSFWKMIGLEDLIGDNYNKIGNLVLPPGASLGSGLIPEAARELGLPSGIAVAASLIDAHAGGLGVIGADVRGHGLTCEGQPVTSRLAVICGTSSCHMGISKDPIFVPGVWGPYFSAMVPGFWLNEGGQSVTGKLIDHMVQSHPAFPELQAKATARCQSIYAYLNSHLDLIKKAQPVGFLTVDLHVWPDFHGNRSPLADLTLKGMVTGLTLSRDLDDLAVLYLATIQAIAFGTRFIIETMEAAGHSLSTLFLCGGLSKNPLFVQMHADITGMPVVLSQEVESVLVGAAILGACASGDFASVQEAMARMSKVGKVVFPERADKKYYDKKYQVFLRMVEHQKEYSAIMNGS
The following text describes a protein:
Function:
Possesses endoamylolytic activity in vitro, but seems not required for breakdown of transitory starch in leaves. May be involved in the determination of the final structure of glucans by shortening long linear phospho-oligosaccharides in the chloroplast stroma. Can act on both soluble and insoluble glucan substrates to release small linear and branched malto-oligosaccharides. Works synergistically with beta-amylase toward efficient starch degradation. Has activity against p-nitrophenyl maltoheptaoside (BPNP-G7), amylopectin and beta-limit dextrin. Involved in stress-induced starch degradation.
Subcellular Localization:
Plastid, chloroplast.
Domain:
The N-terminal domain is not required for endoamylolytic activity.
Sequence:
MSTVPIESLLHHSYLRHNSKVNRGNRSFIPISLNLRSHFTSNKLLHSIGKSVGVSSMNKSPVAIRATSSDTAVVETAQSDDVIFKEIFPVQRIEKAEGKIYVRLKEVKEKNWELSVGCSIPGKWILHWGVSYVGDTGSEWDQPPEDMRPPGSIAIKDYAIETPLKKLSEGDSFFEVAINLNLESSVAALNFVLKDEETGAWYQHKGRDFKVPLVDDVPDNGNLIGAKKGFGALGQLSNIPLKQDKSSAETDSIEERKGLQEFYEEMPISKRVADDNSVSVTARKCPETSKNIVSIETDLPGDVTVHWGVCKNGTKKWEIPSEPYPEETSLFKNKALRTRLQRKDDGNGSFGLFSLDGKLEGLCFVLKLNENTWLNYRGEDFYVPFLTSSSSPVETEAAQVSKPKRKTDKEVSASGFTKEIITEIRNLAIDISSHKNQKTNVKEVQENILQEIEKLAAEAYSIFRSTTPAFSEEGVLEAEADKPDIKISSGTGSGFEILCQGFNWESNKSGRWYLELQEKADELASLGFTVLWLPPPTESVSPEGYMPKDLYNLNSRYGTIDELKDTVKKFHKVGIKVLGDAVLNHRCAHFKNQNGVWNLFGGRLNWDDRAVVADDPHFQGRGNKSSGDNFHAAPNIDHSQDFVRKDIKEWLCWMMEEVGYDGWRLDFVRGFWGGYVKDYMDASKPYFAVGEYWDSLSYTYGEMDYNQDAHRQRIVDWINATSGAAGAFDVTTKGILHTALQKCEYWRLSDPKGKPPGVVGWWPSRAVTFIENHDTGSTQGHWRFPEGKEMQGYAYILTHPGTPAVFFDHIFSDYHSEIAALLSLRNRQKLHCRSEVNIDKSERDVYAAIIDEKVAMKIGPGHYEPPNGSQNWSVAVEGRDYKVWETS
The following text describes a protein:
Function:
Acts as a TGF-beta antagonist in the nervous system (By similarity). Exhibits transcriptional repressor activity.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MASSPLPGPNDILLASPSSAFQPDALSQPRPGHANLKPNQVGQVILYGIPIVSLVIDGQERLCLAQISNTLLKNFSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFLGENRPPKLPDNFAFDVSHECAWGCRGSFIPARYNSSRAKCIKCSYCNMYFSPNKFIFHSHRTPDAKYTQPDAANFNSWRRHLKLTDKSPQDELVFAWEDVKAMFNGGSRKRALPQPSAHPACHPLSSVKAAAVAAAAAVAGGGGLLGPHLLGAPPPPPPPPPLAELAGAPHAHHKRPRFDDDDDSLQEAAVVAAASLSAAAASLSVAAATGGAGPGAGGPGGGCVAGVGVGASAGAGAAAGTKGPRSYPVIPVPSKGSFGGVLQKFPGCGGLFPHPYTFPAAAAAFGLCHKKEDAGTAAEALGGAGAGSAGAAPKAGLSGLFWPAGRKDAFYPPFCMFWPPRTPGGLPVPTYLQPPPQPPSALGCALGDSPALLRQAFLDLAEPGGAGGSAEAAPPPGQPPPVVANGPGSGPPATGGTGARDTLFESPPGGSGGDCSAGSTPPAEQGVTSGTGSASSGAGSVGTRVPAPHHPHLLEGRKAGGGSYHHSSAFRPVGGKDDAESLAKLHGASAGTPHSAPAHHHHHHHHPHHHHHHPPQPPSPLLLLQPQPDEPGSERHHPAPPPPPPPPPLAPQPHHRGLLSPEGTSCSYPSEDSSEDEEDEEEEQEVDVEGHKPLEGEEEEDGRDPEDEEEEDEETRVLLGDSLVGGGRFLQGRGLSEKGSGRDRTTPAVGAFPLALNSSRLLQEDGKLGDSGGSDLPAPPPPPLAPQKASSSGGSRPGSPVHHPSLEEEPSYKDNQKPKENNQVIISTKDDNFSDKNKGHGFFITDSDSSGDFWRERSGEHTQETNSPHSLKKDVENMGKEELQKVLFEQIDLRRRLEQEFQVLKGNTSFPVFNNFQDQMKRELAYREEMVQQLQIIPYAASLIRKEKLGAHLSKS
The following text describes a protein:
Function:
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
Sequence:
MARVEIEIPDDVTAEVDHLDLTVEGPEGSVTRRLWYPDVDVSVEDDAVVVASEVDDAKTDSTVGTFESHVANMFHGVSEGWEYKLEVHYSHFPMQVDVEGEEVVIQNFLGEKAARRTQIRGDTDVVVDDEEVTLSGPSIEDVGQTAADIEQLTRVTDKDTRVFQDGVYIVEKPAKGGA
The following text describes a protein:
Function:
Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Phosphorylated CitT binds to the citM promoter to activate the transcription of the citM-yflN operon.
Subcellular Localization:
Cytoplasm.
Sequence:
MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLKEHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYLIKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSITLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPERKYYLAAD
The following text describes a protein:
Function:
Also involved in hydrogenase metallocenter assembly, probably by participating in the nickel insertion step. This function in hydrogenase biosynthesis requires chaperone activity and the presence of the metal-binding domain, but not PPIase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
METVENKYITVAYKLYTVEDGEKELFEETNAEHPFQFISGLGTTLESFENQITALSKGDKFDFTIPADEAYGAYDEQHVFDLPKNIFEIDGKFDSERVTEGSIVPLMTGDGQRVNASVVEIKPDVVVVDLNHPLAGADLIFEGEVIESRPATNEEIQELVKMMSGEGCGCGCDSCGSDCGDDCGCEGGHCH
The following text describes a protein:
Function:
Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLPTGEVVQFNRRTPFLHQRPEREYVPISQWDALVVPPNGEHPKAFMKRISAASETGDNLSESLIRTHGSGDIVRRFHPNHGTTTIAFCFRGGILLAVDSRSTQGQFVSSGVVQKVIEITPHILGTIAGVAGDCQFWERDLGRKCRLYELENGERIYASSASKLFISTLHSQSGADMSVGAMISGFDSTNHPCIYYCDSEGTRIGGYLYGAGSGSTFAFGIVDTEYDFEMTEEQAIALGKKAIYHAVSRDAMSGGMLNVYVIRPGGWEHVLAMDNYEYYRAMHPDAPALPPPPQ
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MVILAASVSTRGGKPVISRQFRDMPRSRIEGLLASFPKLISAGSQHTSVETDAVRFVYQPLEDLYMILITNKNSNILQDIDTLHLFARVTSDICRSLDESSVLRYSFELLGAFDEIVSLGYRENVNLTQVRSILEMESHEEKIQEIIERNKEMEAKEELKRRAKQLEMQRRDAARRGQMGGNSGGFGSSGGYSSVQQRFEPPPTQAPVQTGFSSSSTSAAKPFKGKGMQLGKKSKGAELLGAMGGDLAAAAAAADEELTAAANAASASLAAAANAAPSSAVRAAPAASVAAIDPLDLLEPVQQEPVHVVVKERISITGNRDGGLESLEIKGDLLLKITDPSLAKVRLQLAPPEANNLVLAAGDLQFKTNPQIDKAAWSSDRIVAPRDARKPFPVNQSLGVLRWRMVTKDETALPLSINCWPSPNGEGGCDVNIEYELENEELGELRSVIIAIPLPAGSVPSVECPDGSWTVNDETNNLEWSLDSISSSNKSGSLEFSVTEGADNVDVFFPVVVDFVCEKTLCDVTVTNVVLADTGAPTTFSQQSVLSADNYVIA
The following text describes a protein:
Function:
Binds to the 23S rRNA.
Sequence:
MKLHDLKPTPGSRKDRKRVGRGPGGTDKTAGRGHKGQKSRSGAGKGAFFEGGRSRLIARLPKRGFNNVGTTYEVVKLSQLQDLEDTTFDRDTLEAYRLVRRKNRPVKLLASGEISRAVTVHVDAASAAAIKAVEAAGGRVVLPEVQTQQDDAQKAE
The following text describes a protein:
Function:
Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells. Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK. In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation. Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses.
Subcellular Localization:
Cytoplasm.
Sequence:
MALRNVPFRSEVLGWDPDSLADYFKKLNYKDCEKAVKKYHIDGARFLNLTENDIQKFPKLRVPILSKLSQEINKNEERRSIFTRKPQVPRFPEETESHEEDNGGWSSFEEDDYESPNDDQDGEDDGDYESPNEEEEAPVEDDADYEPPPSNDEEALQNSILPAKPFPNSNSMYIDRPPSGKTPQQPPVPPQRPMAALPPPTAGRNHSPLPPPQTNHEEPSRSRNHKTAKLPAPSIDRSTKPPLDRSLAPFDREPFTLGKKPPFSDKPLIPAGRPLGEHLPKIQKPPLPPTTERHERSSPLPGKKPPVPKHGWGPDRRENDEDDVHQRPLPQPALLPMSSNTFPSRSTKPSPMNSLPSSHMPGAFSESNSSFPQSASLPPYFSQGPSNRPPIRAEGRNFPLPLPNKPRPPSPAEEENSLNEEWYVSYITRPEAEAALRKINQDGTFLVRDSSKKTTTNPYVLMVLYKDKVYNIQIRYQKESQVYLLGTGLRGKEDFLSVSDIIDYFRKMPLLLIDGKNRGSRYQCTLTHAAGYP
The following text describes a protein:
Function:
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSYQEQQCKQLCQPLPVCPPPKPCSPPKCPEPCPPPKCPETCPPQPCQRKCPPVLEAPCQQKCPSKSK
The following text describes a protein:
Function:
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MTKGKRGAFYDDDDLDDGYDDDYDDDYYEEEPAPAPKKAELAKPQAGGKQPAQTAPKAAPSAAPARAAGASKLAQSLCDPPPPGPGGKAQRGAKPDPAVKSLHQPTYPVAPAATSSSPFQFDTPSPDDAVKAAQERKPGAVAPPAAAAAPTAPSLPQNKNFLRPSPMLQQQKQQQGGPANGEGADEAARGVAALGLTSAASGGSEGGTTPGGGTRQHHPHLGHPEAPNALSHPGGLHGLHTRRPVTEYVMEADLARDVAAATASESSSTSTSGSSSGSSKPPLHLVVLGHVDAGKSSLMGRLLHDLGLVSAKEAHKFQRDAAAAGKGSFAWAWVLDERPEERERGVTMDVAMTRFATNRFAVTLLDAPGHRDFVPNMIAGAAQADAALLLVDGSPGGFEAGFSEGSGGLHGAPGGQTREHAALARSLGIEQMAVVVSKLDTCGYDQSRFESIRAALLPYLKSVGFKESGLQWLPAAGPLGENLVGPPQDPALKAWWGPGRPCVTDAIDAFAPRERAVSRPLRLPVSDVFKSKTGAVVLGGKLEGGAMRPGSRVVLVPGPAQPFAVRSLEVGGGAANLARAGDSCEVALVAHGGGGGGGGAIDPSLVAPGAVLCHADFPAVLVTKFQLRLVVLDVPVPLLRGQAVTLHAHVAREEGHLSALVALLDPRTGEEVKARPRCLTRGQSALVEVTSSRGLVLEEYAHYRALGRVALREGGRTLAVGVVTQLLE
The following text describes a protein:
Function:
Involved in biosynthesis of legionaminic acid (5,7-diamino-3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg), a sialic acid-like derivative that is incorporated into flagellin via O-linkage to Ser/Thr. Catalyzes the conversion of N,N'-diacetyllegionaminic acid (Leg5Ac7Ac) and CTP into CMP-N,N'-diacetyllegionaminic acid (CMP-Leg5Ac7Ac).
Sequence:
MAEILCTICARGGSKGVKNKNIRKINKLEMIAYSIIQAQNSKLFKHIVISTDSDEIASVAQKYGAEVFFKREAHLANDRTAKLPVMRDALLRSEEHFKTCFETLIDLDASAPLRSSLDIKKAYESFVENDNSNLITAVPARRNPYFNLVEIQNNKVVKSKEGNFTTRQSAPKCYDMNASIYIFKRDYLLENDSVFGKNTGLFVMDESTAFDIDSELDFKIVEFLISLKNLSPKDF
The following text describes a protein:
Function:
Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2) by facilitating the incorporation of copper into the Cu(A) site of MT-CO2/COX2.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MDRACLRIVRKAPTWQLYHRQTNLLEAQRRSLRSISLTRQSRNVFKFHNSKPQTLCVSWSVSSLRNVSDIPTPRKPTVTGSPIGWKSVLFLVSCGSIMVLAMKFYKNKREKEVDNEMIKSYGRPELGGDFELIDHTGMLRTNKDFLGQWILIYFGFTHCPDICPEELEKMGNVVDTVNRNQHVPDILPVFISIDPERDTTEAVKAYIADFHPLMVGLTGTREQVDKASHAFRVYYSAGPKDDDSDYLVDHTIIMYLIDPDGDFCEYFGQNKSAGEIASTITATMFKSKRNS
The following text describes a protein:
Function:
RNA-binding protein that associates with the RNA exosome complex (By similarity). Involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA) derived from intergenic regions and the ribosomal DNA spacer heterochromatin.
Miscellaneous:
MISCELLANEOUS: Present with 1350 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Note=Colocalizes with the nuclear exosome and ribosomes.
Sequence:
MSANNGVTGKLSSRVMNMKFMKFGKTDDEESSNSNTPSNINSDVEPIEQKGKLFGLDDSAWDLNSYKDDLKKISGKEKKKVKRVVYKKRPNLIISNVGYSELRKPEGVISGRKTFGDNSDDSGSRKRKFDEGEQNEDEKRDAKDKEFTGSQDDGEDEYDLDKLFKDSIKKKKTNHNGKNKNRNSKK
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MELDTADIIKMFERSDVEILNRAGGIEGLAEMFKTNLVDGISKGEAESHYHDRIELYGINKLPDPPQKTWCRFYIETFKDITLKILFVAIFISFVFVFVVHYKHLEFTEFIDTISIVFALMLVSCVTAQTNYQQQQAYLEINNVKNTFPVTVIRAGERQQILSTQVMVGDILELKAGDAVAADCVFINGTNLTINNSAMTGEPIGVKVTHKDPFLRGGGAIENGIGTALVAAVGPNSQYGVTMTTITNLGATETETPLQKKLNKLAVQLLYVAVVCASVTFVVVIGEWVAHLVKALKSKTFNKTIIQDLLNRIMTVITIFLCCVPEGLPLAVTLCLSFSMKKMMKDQNFVRHLSACETMGGATTICSDKTGTLTQNRMTVVKFWMDGVEQDGHPDLIEEVKERLAESIAINSTASHTLKEGTDEVVFVGSSSECALLKMISDLGKDYMEIRELNPILYLNEFNSARKRMSTVVSSENGCHVYFKGAPDFSLPLISHYLANDGSVKEANQAFKASVLAKVNDFASQAYRTMLIAYREIVGEESQQWSDPNFVESNLTMIALVGIQDPLRPEVPLAIQRCKEAGVVVRMVTGDFIATARAISKQCGIISSETDIVMEGAEFASLSKTQLIDKIDNLRVLARSSPTDKYRLVSLLMECGEVVAVTGDGSNDSAALKKANVGFAMGMCGTELAKVASDIVILDDNFSSIVSALKWGRGIYDNLRCFLTFQIPVNFVAVACAIVGSIAIGDSPLKPIQVLWMNLIDDSLGALALATRPPADFLLKRAPYGSNDSIVSNIVFRNIAFQTCYQILCLFLILFGHEKIFGVVDPTENKYNTSSWIFNTFVYMNVFYLVPARRASNDGSVWQGFFQNYYFHAILISLAVVQIPIVCWFGRAFYTVKPTTKEWLITMAMSVGAFVWAFITNAWHLPDHTLENLNAYRRMRKEQVRAYYSGMTHEQQWDDKNAMKEIDVDAKPAKAAKPQIEEDLIP
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MNQPIEPDHINVPTEALESLRLRLTQVSHSLNTLQAQLHQPTLPPWSSLHNQFNVLLTQLVSLSSTITHQSDILQQTVTFPLPAFPTATEAGLMATLLRKKILPEVEEWCEEVKQKALGVKIRTVDQYGEWAAETVEEAKQEYEWYGLMTREEVDNGVKPPVYVAPEEEAGEGAKLTIEQILQFTCAGKMPTVA
The following text describes a protein:
Function:
Plays a role in left-right patterning process.
Subcellular Localization:
Secreted.
Sequence:
MWGSPALAWAVWLACVQPTVFPWSLSFRSDTDKPSSAAEVLTEASSCWTDTVECFSDYMTLWIPRSHVEGLRRWLARTLHLPGTWRSPDHLDSSLAKCGYFLHLASDGDFLFRVQYSACFVQKEKANYRLEIRIFQKGVMGLERSDRYIMKCPMLRSRLGQESVHCGPMFIQVSRPLPLWRDNRQTPWLLSLRGELVASLEDASLMGLYVDMNATTVTVQSPRQGLLQRWEVLNTSAELLPLWLVSGHHAYSLEAACPPVSFQPESEVLVHIPKQRLGLVKRGSYIEETLSLRFLRVHQSNIFMVTENKDFVVVSIPAAGVLQVQRCQEVGGTPGTQAFYRVDLSLEFAEMAAPVLWTVESFFQCVGSGTESPASTAALRTTPSPPSPGPETPPAGVPPAASSQVWAAGPAAQEWLSRDLLHRPSDALAKKGLGPFLQTAKPARRGQTSASILPRVVQAQRGPQPPPGEAGIPGHPTPPATLPSEPVEGVQASPWRPRPVLPTHPALTLPVSSDASSPSPPAPRPERPESLLVSGPSVTLTEGLGTVRPEQDPAKSPGSPLLLRGLSSGDVAAPEPIMGEPGQASEEFQPLARPWRATLAAEELVSHRSPGEPQETCSGTEVERPRQTGPGLPREGARGHMDLSSSEPSQDIEGPGLSILPARDATFSTPSVRQPDPSAWLSSGPELTGMPRVRLAAPLAVLPMEPLPPEPVRPAALLTPEASSVGGPDQARYLESAPGWPVGQEEWGVAHTSSPPSTQTLSLWAPTGVLLPSLVELEYPFQAGRGASLQQELTEPTLALSAESHRPPELQDSVEGLSERPSR
The following text describes a protein:
Function:
May play a role in the formation or function of ciliated cells.
Sequence:
MAVTSWLEVLRSAEKTALLQDGKRMVHYLFPDGKEMAEEYDEKTSELLVRKWRVKNALGALGQWQLEVGEPVPSGAGSLGSELIKESNANPIFMRKDTKTSFQWRIRNLPYPKDVYSVSVAQKERCVIVRTTNKKYYKKFSIPDLDRHQLPLEDSALSFAHANCTLIISYQKPKEVMAAESELQKELKKVKTAHGSAGDCKTQ
The following text describes a protein:
Function:
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
Subcellular Localization:
Chromosome, centromere. Nucleus.
Sequence:
MEMAADKNSSFMPANGGDGHNSSLGKLLNSEEDPPVVFLCSHCKRPVGDTYSWMGSDMGDQTILLKAVSEYVSVDEVQIVSKVASDYGCTFETVSCSGCSSVMGKIYRCTPKHLDFKRDLFSLNIDAVDSYILGSAHKEAVLEFEEPVTLGVRAAFEEEIEKTRAVLNVLQSRVSTIEAHMFSGKDLSSTLDVDITDLREKSFPKS
The following text describes a protein:
Function:
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.
Subcellular Localization:
Cell projection, cilium, flagellum membrane; Single-pass type I membrane protein.
Sequence:
MCGPAMFPAGPPWPRVRVVQVLWALLAVLLASWRLWAIKDFQECTWQVVLNEFKRVGESGVSDSFFEQEPVDTVSSLFHMLVDSPIDPSEKYLGFPYYLKINYSCEEKPSEDLVRMGHLTGLKPLVLVTFQSPVNFYRWKIEQLQIQMEAAPFRSKEPCMAEEVCSMSWYTPMPIKKGSVVMRVDISSNGLGTFIPDKRFQMNINGFLKRDRDNNIQFTVGEELFNLMPQYFVGVSSRPLWHTVDQSPVLILGGIPNEKYVLMTDTSFKDFSLVELSIDSCWVGSFYCPHSGFTATIYDTIATESTLFIRQNQLVYYFTGTYTTLYERNRGSGSWIRVLASECIKKLCPVYFHSNGSEYIMALTTGKHEGYVHFGTIRDGQVSFEMLPRQWSVCEQIGVTTCSIIWSEYIAGEYTLLLLVESGYGNASKRFQVVSYNTASDDLELLYHIPEFIPEARGLEFLMILGTESYTSTAMAPKGIFCNPYNNLIFIWGNFLLQSSNKENFIYLADFPKELSIKYMARSFRGAVAIVTETEEIWYLLEGSYRVYQLFPSKGWQVHISLKLMQQSSLYASNETMLTLFYEDSKLYQLVYLMNNQKGQLVKRLVPVEQLLMYQQHTSHYDLERKGGYLMLSFIDFCPFSVMRLRSLPSPQRYTRQERYRARPPRVLERSGFHNENSLAIYQGLVYYLLWLHSVYDKPYADPVHDPTWRWWANNKQDQDYYFFLASNWRSAGGVSIEMDSYEKIYNLESAYELPERIFLDKGTEYSFAIFLSAQGHSFRTQSELGTAFQLHSQVDVGVVLADPGCIEASVKQEVLINRNSVLFSITLKDKKLCYDQGISGHHLMETSMTVNVVGSSGLCFQETHLGPHMQGNLMVPVFIGCPPGKRLAFDITYTLEYSRLKNKHYFDCVNVNPEMPCFLFRDIFYPFFLIQDLVTGDSGSFQGSYVLLVVGGGPTLDSLKDYSEDEIYRFNSPLDKTNSLIWTTRTTRTTKDSAFHIMSHESPGIEWLCLENAPCYDNVPQGIFAPEFFFKVLVSNRGVDTSTYCNYQLTFLLHIHGLPLSPKRALFIIMVSASVFVGLVIFYIAFCLLWPLVVKGCTMIRWKINNLIASESYYTYASISGISSMPSLRHSRMGSMFSSRMTEDRAEPKEAVERQLMT