lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Initiates the restart of stalled replication forks, which reloads the replicative helicase on sites other than the origin of replication. Recognizes and binds to abandoned replication forks and remodels them to uncover a helicase loading site. Promotes assembly of the primosome at these replication forks.
Sequence:
MGYLAPAGKKRSSHVMLSDSSLSNLGDPTLNFPPFAAAPVPADSSSSEPTQNELFETDPPPWELTVGEDVQLASIVFARSPHGPYDYRIPDDLLDVLRPGMRVGVPLGHRKKPTPGWCVSIKTGNAAQKKLRDVSEVIDDEPLCDAALVRLVMFIAHYYQVPAGQVFDTLIPASVRDNAGTRKTTYFRPAPGLTEEQIAKLPSKQQSAMRFLIAQDRPMTAAEIAIMAECTEDPIRRLRKKELLVPEVRRELSQNIRIRAQANDGETRKTHDLTAQQENALSRINSAVDSGRGRTLLLHGVTGSGKTEVYIQAIEHVVKQAGSAIVLVPEISLTPQTRGRFEDRFQNVAVLHSQMSASERHFHWQRIRRGEVQVVIGPRSAVFAPLPNLGLIVIDEEHDTSFKQDKQPRYHARKVAHARAMALGIPLVLGSATPSMEAWHATQTGHAELVTMSERVGNRPMPDVQLVDLRVKEERGKGGAISRPLHAAVLETLKEKGQAILLLNRRGYATTIQCPACGTVCACPDCDMPLTHHRDGGKAMCHYCDYTIPTPPWCPACRFDGMRYGGLGTQRLEMEAKARFPDARIARMDSDTMKRAGSHQRVLSEFRAGEIDVLLGTQMIAKGLDFPNVLLVGVINADSALHFPDFRAAERTFQLVTQVAGRTGRGDRGGRVIVQTFTPEHPAIQAAARHDYLKFVEDEMVNRKKFNYPPLGSVARIIIRGPLEDKTESVADAIVDRLEKARDLLKAEVRILGPAPPPIVKISGKYRFHLLLQATEAAVVGEVIRRGLADFKVDPKEEIEFLVDIDPVNLM
The following text describes a protein:
Function:
Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity. Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses. Directly binds dsRNA, activating the nucleotidyltransferase activity, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the immune response via activation of the NF-kappa-B transcription factor.
Sequence:
MSLSRSLDLTQEDYAVQDAILQYISSNFVSLKPPDVKFFKRHLENVTKVLIQMMRKEDNLFNLIFQKERVAGSFWDKLKIGHPIEFDKNFVLTLPPALYKNIKFTPASPSYVTVNVQNGLKIVKSSKCRTYRPDWFDDNGNILSDKLRFWMESVVNKALATLPPLPNKKYQLEIEGTCYEIGTRKSGPAVTVEVNIDSSGSTYLGITQFCIDLVPAFEFQTKDWPHHIRQCPADTQDKTWNLVPKPLKPEENTADGNIPARLQWRLSFHNQESYIIHNLNHFKAVLKLLKKLRDVKFDQYKMSSYALKTVFMLEKERQNNDFWRRPLSSTFLHMLTVLTEWYGKGKIPFYWDKQHNLLGKLSKDQIKQVYCTLQKINNRIYEGLQSKCESKCDHFIIASTLLDSEELLKIKKDIIVDRSGNKPLAKRQRCS
The following text describes a protein:
Function:
Transcription factor required for quiescent center cells specification and maintenance of surrounding stem cells, and for the asymmetric cell division involved in radial pattern formation in roots. Essential for both cell division and cell specification. Regulates the radial organization of the shoot axial organs and is required for normal shoot gravitropism. Directly controls the transcription of SCR, and when associated with SCR, of MGP, RLK, TRI, NUC and SCL3.
Miscellaneous:
MISCELLANEOUS: Moves via plasmodesmata from the stele into the adjacent cell layer where it locates in the nucleus to controls SCR transcription and endodermis specification. Intact microtubules are required for cell-to-cell trafficking of SHR. This intercellular movement is dependent upon the endosome localized protein SIEL. It is necessary for normal patterning of the root.
Subcellular Localization:
Cytoplasm. Nucleus. Early endosome. Late endosome. Recycling endosome. Note=Cytoplasm and nucleus in the stele. Restricted to the nucleus in adjacent cells. Localization to endosomes promotes the intercellular movement of SHR.
Sequence:
MDTLFRLVSLQQQQQSDSIITNQSSLSRTSTTTTGSPQTAYHYNFPQNDVVEECFNFFMDEEDLSSSSSHHNHHNHNNPNTYYSPFTTPTQYHPATSSTPSSTAAAAALASPYSSSGHHNDPSAFSIPQTPPSFDFSANAKWADSVLLEAARAFSDKDTARAQQILWTLNELSSPYGDTEQKLASYFLQALFNRMTGSGERCYRTMVTAAATEKTCSFESTRKTVLKFQEVSPWATFGHVAANGAILEAVDGEAKIHIVDISSTFCTQWPTLLEALATRSDDTPHLRLTTVVVANKFVNDQTASHRMMKEIGNRMEKFARLMGVPFKFNIIHHVGDLSEFDLNELDVKPDEVLAINCVGAMHGIASRGSPRDAVISSFRRLRPRIVTVVEEEADLVGEEEGGFDDEFLRGFGECLRWFRVCFESWEESFPRTSNERLMLERAAGRAIVDLVACEPSDSTERRETARKWSRRMRNSGFGAVGYSDEVADDVRALLRRYKEGVWSMVQCPDAAGIFLCWRDQPVVWASAWRPT
The following text describes a protein:
Function:
May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
METRAAENTAIFMCKCCNLFSPNQSELLSHVSEKHMEEGVNVDEIIIPLRPLSTPEPPNSSKTGDEFLVMKRKRGRPKGSTKKSSTEEELAENIVSPTEDSPLAPEEGNSLPPSSLECSKCCRKFSNTRQLRKHICIIVLNLGEEEGEAGNESDLELEKKCKEDDREKASKRPRSQKTEKVQKISGKEAGQLSGAKKPIISVVLTAHEAIPGATKIVPVEAGPPETGATNSETTSADLVPRRGYQEYAIQQTPYEQPMKSSRLGPTQLKIFTCEYCNKVFKFKHSLQAHLRIHTNEKPYKCPQCSYASAIKANLNVHLRKHTGEKFACDYCSFTCLSKGHLKVHIERVHKKIKQHCRFCKKKYSDVKNLIKHIRDAHDPQDKKVKEALDELCLMTREGKRQLLYDCHICERKFKNELDRDRHMLVHGDKWPFACELCGHGATKYQALELHVRKHPFVYVCAVCRKKFVSSIRLRSHIKEVHGAAQEALVFTSSINQSFCLLEPGGDIQQEALGDQLQLVEEEFALQGVNALKEEACPGDTQLDEGRKEPEAPGEMPAPAVHLASPQAESTALPPCELETTVVSSSDLHSQEVVSDDFLLKNDSSSAEAHAAPEKPPDMQHRSSVQTQGEVITLLLSKAQSAGSDQESHGAQSPLGEGQNMAVLSTGDPDPSRCLRSNPAEASDLLPPVAGGGDTITHQPDSCKAAPEHRSGITAFMKVLNSLQKKQMNTSLCERIRKVYGDLECEYCGKLFWYQVHFDMHVRTHTREHLYYCSQCHYSSITKNCLKRHVIQKHSNILLKCPTDGCDYSTPDKYKLQAHLKVHTALDKRSYSCPVCEKSFSEDRLIKSHIKTNHPEVSMSTISEVLGRRVQLKGLIGKRAMKCPYCDFYFMKNGSDLQRHIWAHEGVKPFKCSLCEYATRSKSNLKAHMNRHSTEKTHLCDMCGKKFKSKGTLKSHKLLHTADGKQFKCTVCDYTAAQKPQLLRHMEQHVSFKPFRCAHCHYSCNISGSLKRHYNRKHPNEEYANVGTGELAAEVLIQQGGLKCPVCSFVYGTKWEFNRHLKNKHGLKVVEIDGDPKWETATEAPEEPSTQYLHITEAEEDVQGTQAAVAALQDLRYTSESGDRLDPTAVNILQQIIELGSETHDATALASVVAMAPGTVTVVKQVTEEEPSSNHTVMIQETVQQASVELAEQHHLVVSSDDVEGIETVTVYTQGGEASEFIVYVQEAMQPVEEQAVEQPVQEL
The following text describes a protein:
Function:
Contributes to nuclear envelope stiffness in germ cells (By similarity). Involved in male and female fertility.
Subcellular Localization:
Nucleus inner membrane; Multi-pass membrane protein; Nucleoplasmic side.
Sequence:
MEKLAAFILVLTLLCAYWQSAEGIREYSYADCTDVKGDSAHRYSGSRCFCYSPGTVIKWKDIWSTFKVNVSSNVDVVVVFPMETINCHHPDDLLTVMNCFVEHYWPSTVQRETSLEIPLVDVDICFMIKSPRSNTEYTLHVSNKRLNRMCFLLFVCGLILFFGARNICRSSLFFYTTGVSLGIIATFVFLTLLLRNFVPKRGLFLVLLGAGSGLSYMGIQRVLNEWDDIVTEHWMELLAYVLISGLFSFAVCYKHGPITNKHTLNFMTCSMQAVGIVLLYYGITFPPAYFVLVAVLLCWKILPLAWSLLMGICSLFYSFLALFRRRRRPTVRLLTEEEYREQGEIHTRASLDELREYCNRPGFPAWETVLRLRSPQRFAEFLRQGSHITQEEHQNHENHYGLGGAYYENVIFNNSSSSDTQSHREEAEDNSEDEIVGNSPPVLNNLPSPTIYPPTICPYPPVTYTPQPEPLDPEDQDFF
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MRHRESLFVLTDFALYPTGMAVLRCSAVTAASRPLAFVLAPYTEPSFNLLDYLGTCTDTALVLCVAVARLLLLCLMWFSRAVAPIALGAPGGAFVFDTGEELYDDARFSMVRNWDGVHMFFIAQCGYLYESQIVFFPGLPALIRGLEHVTRRLIPVLHRVAPVAFYVCLVNIAASCLAGVVLRRLTILTFLGPEAVRCTCRWRPSKLSPSTPELEKPRKYAKAQLDVAAETTMQSTTEATVCYRLMCRMIGTVLEAPDIHAPLPAAVAEAKADALRRRRVVGGAALVWIITPAMVFAVAVYTESLFSLATMLGVYFLAWHEPLPQAVQLRIASYLASVTSPGSAARATEKASVPARLVPPAPLVQQWALATNDVGDGAAARSRIPGIASLLPSFTHGAPRAITVKWEQRFLSSTEVAAVLLFTLAGTFRSNAFTYAGFLIFPICVQVALPAVYRAQASAVLAGVSARAVMSAAAKRGGARDGRATVVVRCPTLRPPLQRMPHPLRMCIVALECICVALPYIVMNYMGYRRFVLQLWDAAAKKTMGQAFWRLYPMLQKKYWGVSLFSAYTFANFPNVVLALPVAVLTAWCLHAHYLAPAWANLRATTAAAAGARRMRWQHLWIAAMPLLSSSNVAHLVGLSTLALTLMHVQVTNRFVTTSPALYWLLGMQLASRPTSRATKLTLLWCILWGMAGGILFPNHLPWT
The following text describes a protein:
Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins.
Sequence:
MTKRNSRKKKTSSSNSQSTSNHKFSIFEFNPDDERVEKHSKKLLQAFKLQKPKKIHSPIDKYTFLGFFEGRTRSSENDSVNEILHIDDSDDIAEKKTLESGATVASSFSSLKPSTDYSLGHLESKCDTSGAKSHLTRAKIPGCSVTDGKSFRGKLFADNEPVILDSDDATEIESSKPACYLPENKGSGNQQELMQSPNLCDKKISVIVKPDRVEYGDTCSTSSILTFSCSSIKLEGSSKWMNLPFTYEWTHCDILTINSMWYKITGAVVLKFALFHPDWSETQEAIKMLDVRYKDKWNDITSLDCTRSYSPFFGQKSNSVSKHYHPKDNFEEVIYPEGDPDAVSISKRDVDLLQPKNFINDTIIDFYIMYLRNKINPEEKDRFHFFNSFFFRKLADLDKDPTRACEGRAAFQRVRRWTTKVNFFGKDFIFIPVNFSLHWSLIVICHPGEVVTFRGEEEMEKSSRVPCILHMDSIRGSHKGLKNLLQSYLLEEWKERHKEVAEDVARKFSNLPFFSLKLPQQENSFDCGLFLLHYVELFLEQAPVNFNLSKITASSKFLAGDWFSTEDVDCKREHIKRLICEITKIRVQKVSSADCDDNYSLHCLEEENTCMNVPQETCNAREACPGGDLSSHEAELLTMSPVANLIRGLKSAAVSEVVSRDLLQAPDSAKPLTYDNDGQKALLDPFRNVMSPIEEEAIGEQMSISPAIKAGSQPIELFAAPHASSSSKAETMFPGRASPLSKKITPGSQSYGCRSPNSLDDEELKAEVEEVSAPDADSPISTEELAGYIVLDSQEEDENHDPNGLENNLPTTATISASCHKEVNSTDIYDYKAAKKPRPVPEVLEVSSSGTGNDETVPSSTSCEEVASLYIQDSEVVNSANCSEIDNLGPATGSRIKHVAGQMRYLFRRRRRGG
The following text describes a protein:
Function:
As a component of the decapping complex, involved in the degradation of mRNAs. Promotes P-body formation. Translational repressor.
Subcellular Localization:
Cytoplasm, P-body.
Sequence:
MAEPKSASGSADSYIGSFISLTSKSEIRYEGVLFSINTEESSIGLQNVRSFGTEGRKKDGPQIPPGDKIYEFILFRGSDIKDLQVKSSPPVNAVLQMQHDPAIIQSHYSRATPVSTGLASTASGSVTDADSYGERSTLPPPSLQGSLPQYQTGTILGPWVSAPAHLNVPMYWQGYYGLSNGLPHVQQQPVPFQPSPGLMASYSLQQHLPNPDAHASFLTKLPTMSDVTSSLPLPILPITSSSLPCTIAPLQISTSLSTDLSPVLSSKASLSSPPTSTLTSNLLTISSSLSPLQEVNVMVTPISSKPRAACLSTLPAQSVSQSASSMAVSSTSSILSDTAPALPDPILQVGVPLPSTARMLYAEQRDIQSVVPPSLDPSSLISPPQNQAPLLPLPIPRNKQIQRSANEFTEEFDFIAMNDKFKKDEVWGHLGKAKVREKVEDEVEHNPDDGDAGDSERHGQHHPKLDAKPVYIKDEFFDSLSSNIASRGMWNGRTRYSERMKLDTETFGDFNQKAHLGHGGRGVGHRWDSRGPSYRGRGYGYGGWGRGG
The following text describes a protein:
Function:
RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment.
Subcellular Localization:
Nucleus. Note=Component of ribonucleosomes (By similarity). Localizes in numerous small granules in the nucleus.
Domain:
The RRM domain is necessary for RNA-binding, but not for splice site selection, indicating that its splicing activity does not require direct binding to RNA.
Sequence:
MVEADRPGKLFIGGLNTETNEKALEAVFGKYGRIVEVLLMKDRETNKSRGFAFVTFESPADAKDAARDMNGKSLDGKAIKVEQATKPSFESGRRGLPPPPRSRGPPRGLRGGRGGSGGTRGPPSRGGHMDDGGYSMNFTLSSSRGPLPVKRGPPPRSGGPPPKRSAPSGPVRSSSGMGGRAPVSRGRDGYGGPPRREPLPSRRDVYLSPRDDGYSTKDSYSSRDYPSSRDTRDYAPPPRDYTYRDYGHSSSRDDYPSRGYSDRDGYGRERDYSDHPSGGSYRDSYESYGNSRSAPPTRGPPPSYGGSSRYDDYSSSRDGYGGSRDSYTSSRSDLYSSGRDRVGRQERGLPPSMERGYPPPRDSYSSSSRGAPRGGGRGGSRSDRGGRSRY
The following text describes a protein:
Function:
Involved in transcriptional regulation. Component of the NC2 complex which represses RNA polymerase II transcription through binding to tbp and thereby inhibiting the assembly of the preinitiation complex (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MKKKYKTKFPMARIKKIMQKDEEVGKIASATPILISQCLELFMADLVMKTCKITQAKKGKVISVNHLKECIKQESTFDFLTEIVDRIPDDKNEKRGRPKKTEGEDGGEEEEEEEEEMDMGEEEEEEEDEDDDDSDEEEEEAPKKGGKGSRGGKGSRGGRGGARGGASTRKVKSETSPVLKNTTITTTTATTTPTPTPTPNFANSPKDIQSTSLKKPSARKSNTTSPKSSPFLSSSAGSIQSPPLNNNNNNNNNNNNNNNNNGNFNNNNNFNNNNNNFNNNNNFNNNNFNNNNNNNNFNNNSNNNNNNFNNNNFNNNNYNSNEDENNNNNNNNNNKNNNNNNNSNNSNNNNRGQQFLSSSTASTITLPSNQYQPLAPISLPVLNNSNNNNSSNNNNNNNNNNNNNNNNNNEHILGNLNNNNSNRKINTNFDEEDSNHNINKSNINSIMNSSNNSIDNKDNGFNSFTFSNNNSNFNDNNNYNPNNPNNNNDNNGNGIVLPSLSSTNSSSTLPSFSSVPPILNTNNSNSNNSISHILNNLNSKKPNVEDEDFD
The following text describes a protein:
Function:
Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLNYVIKRLLGLIPTLFIVSVLVFLFVHMLPGDPARLIAGPEADAQVIELVRQQLGLDQPLYHQFWHYISNAVQGDFGLSMVSRRPVADEIASRFMPTLWLTITSMVWAVIFGMAAGIIAAVWRNRWPDRLSMTIAVSGISFPAFALGMLLIQVFSVELGWLPTVGADSWQHYILPSLTLGAAVAAVMARFTRASFVDVLSEDYMRTARAKGVSETWVVLKHGLRNAMIPVVTMMGLQFGFLLGGSIVVEKVFNWPGLGRLLVDSVEMRDYPVIQAEILLFSLEFILINLVVDVLYAAINPAIRYK
The following text describes a protein:
Function:
Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.
Sequence:
MASEGMAPAELQAEGGTAVEPESGFGQLLEEEEEDGGYVLYRYGRVSAASERLGHVFPGTDVRRRGGGGGMLRRRTRTRKEGSGHRCVCFTVRVALYKHWKFENIFVCAYRDRKEWADIEPVPQNDGPNPVVQIIYSEKFRDVYDYFRAVLQKDERSERAFKLTADAIELNAANYTVWHFRRVLLQSLGKDLYEELKYITAIIEDQPKNYQVWHHRRVLVEWLQDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFKLWDDELEYVDQLLREDVRNNSVWNQRYFVIFNTTGYDDPAVLDREVQYTLEMITAVPHNESAWNYLKGILQDRGLSKYPNLLEQLLSLQPSHSSPYLIAFLVDIYEDMLENQCENKEETLNKALELCEILAKEKDTIRKEYWRYIGRSLKNKHSSNTEQSTVTDKQQ
The following text describes a protein:
Function:
Probable transcriptional factor. Binds to the promoter of the SQUAMOSA gene.
Subcellular Localization:
Nucleus.
Sequence:
MLDYEWENQSSFMFTSDQNTQEENDQNNNQFLDPQAHFPHITSYQHPQQQQQQQLQNPHFPQFQATPNNTHLISSMYDPRAYGVPYTQTHDTSMLSLQPTGGFMVVPKSEPQFGGGIHDFSSSSSRIGLNLGGRTYFASSSEDDFVNRLYRRTRAVDAGSVNSPKCQAEGCNADLTHAKHYHRRHKVCEFHSKASTVIAAGLTQRFCQQCSRFHVLSEFDNGKRSCRKRLADHNRRRRKNIQQENNKKQPQPSSKSPAESGAQSSTVTVAISPPRIPVDGFRQRTYQQVTTSSSFPMGD
The following text describes a protein:
Function:
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.
Sequence:
MAPLGEVGNYFGVQDAVPFGNGPVLPVDSPVLLSDHLGQSEAGGLPRGPAVTDLDHLKGILRRRQLYCRTGFHLEIFPNGTIQGTRKDHSRFGILEFISIAVGLVSIRGVDSGLYLGMNEKGELYGSEKLTQECVFREQFEENWYNTYSSNLYKHVDTGRRFYVALNKDGTPREGTRTKRHQKFTHFLPRPVDPDKVPELYKDILSQS
The following text describes a protein:
Function:
Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled repair (TCR) factor RAD26 fails to efficiently displace stalled RNA polymerase II. Also involved in telomere length regulation. Binds DNA.
Miscellaneous:
MISCELLANEOUS: Present with 3380 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Chromosome, telomere. Note=During transcription stress, localizes to the nucleus following proteolytic cleavage by the proteasome.
Domain:
The C-terminal part appears to promote nuclear export.
Sequence:
MSTQFRKSNHNSHSSKKLNPALKSKIDTLTELFPDWTSDDLIDIVQEYDDLETIIDKITSGAVTRWDEVKKPAKKEKYEKKEQQHSYVPQQHLPNPEDDITYKSSNNSNSFTSTKHNSSNNYTQARNKKKVQTPRAHTTGKHVNLDKGKHVPSKPVSNTTSWAAAVSVDTKHDVPQDSNDNNNEELEAQGQQAQEKNQEKEQEEQQQQEGHNNKEEHKQIEQPSLSSKKTTSRTSASQPKKMSWAAIATPKPKAVKKTESPLENVAELKKEISDIKKDDQKSEASEEKVNEQETSAQEQEEETAEPSEENEDRVPEVDGEEVQEEAEKKEQVKEEEQTAEELEQEQDNVAAPEEEVTVVEEKVEISAVISEPPEDQANTVPQPQQQSQQPQQPQQPQQPQQPQQPQQQQQPQQPQQPQQQLQQQQQQQQQPVQAQAQAQEEQLSQNYYTQQQQQQYAQQQHQLQQQYLSQQQQYAQQQQQHPQPQSQQPQSQQSPQSQKQGNNVAAQQYYMYQNQFPGYSYPGMFDSQGYAYGQQYQQLAQNNAQTSGNANQYNFQQGYGQAGANTAAANLTSAAAAAAASPATAHAQPQQQQPYGGSFMPYYAHFYQQSFPYGQPQYGVAGQYPYQLPKNNYNYYQTQNGQEQQSPNQGVAQHSEDSQQKQSQQQQQQQPQGQPQPEVQMQNGQPVNPQQQMQFQQYYQFQQQQQQAAAAAAAAAQQGVPYGYNGYDYNSKNSRGFY
The following text describes a protein:
Function:
Peptidyl-tRNA hydrolase involved in the recycling of tRNA-Lys from diacetyl-lysyl-tRNA-Lys and is important for mitochondrial function.
Miscellaneous:
MISCELLANEOUS: Present with 339 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MSGKWRLVLTGIGNPEPQYAGTRHNVGLYMLELLRKRLGLQGRTYSPVPNTGGKVHYIEDEHCTILRSDGQYMNLSGEQVCKVWARYAKYQARHVVIHDELSVACGKVQLRAPSTSIRGHNGLRSLLKCSGGRVPFAKLAIGIGREPGSRSRDPASVSRWVLGALTPQELQTLLTQSEPAAWRALTQYIS
The following text describes a protein:
Function:
L,D-endopeptidase that cleaves meso-diaminopimelic acid (mDAP)-mDAP cross-links in peptidoglycan. It works in conjunction with other elongation-specific D,D-endopeptidases to make space for efficient incorporation of nascent peptidoglycan strands into the sacculus and thus enable cell wall expansion. In vitro, is able to cleave the mDAP cross-links of soluble muropeptides and of intact peptidoglycan sacculi. Shows a weak D,D-endopeptidase activity.
Sequence:
MDKFDANRRKLLALGGVALGAAILPTPAFATLSTPRPRILTLNNLHTGESIKAEFFDGRGYIQEELAKLNHFFRDYRANKIKSIDPGLFDQLYRLQGLLGTRKPVQLISGYRSIDTNNELRARSRGVAKKSYHTKGQAMDFHIEGIALSNIRKAALSMRAGGVGYYPRSNFVHIDTGPARHW
The following text describes a protein:
Function:
Exhibits racemase activity for both L-glutamate and L-aspartate, but has threefold higher activity for L-glutamate than L-aspartate. Cannot use D-glutamate or D-aspartate as substrate.
Sequence:
MKTIGLLGGMSWESTIPYYRLINEGIKQRLGGLHSAQVLLHSVDFHEIEECQRRGEWDKTGDILAEAALGLQRAGAEGIVLCTNTMHKVADAIESRCTLPFLHIADATGRAITGAGMTRVALLGTRYTMEQDFYRGRLTEQFSINCLIPEADERAKINQIIFEELCLGQFTEASRAYYAQVIARLAEQGAQGVIFGCTEIGLLVPEERSVLPVFDTAAIHAEDAVAFMLS
The following text describes a protein:
Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSPPNQSVEGLLQEGSNRSLNATETPEAWDPGTLQALKISLAVGLSTITLATVLSNAFVLTTIFLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTGTWSFGQILCDIWLSSDVTCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAHEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYSRIYVAARNRILNPPSLYGKRFTTAHLIAGSAGSSLCSLNPNFHEGQSHSGSPLFFNHVKIKLADSVLERKRISAARERKATKTLGIILGAFIICWLPFFVASLVLPLCRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVHFRKAC
The following text describes a protein:
Function:
Activates the expression of genes on pathogenicity island 1 (SPI1) that encode virulence proteins involved in invasion of host cells.
Sequence:
MENVTFVSNSHQRPAADNLQKLKSLLTNTRQQIKSQTQQVTIKNLYVSSFTLVCFRSGKLTISNNHDTIYCDEPGMLVLKKEQVVNVTLEEVNGHMDFDILEIPTQRLGALYALIPNEQQTKMAVPTEKAQKIFYTPDFPARREVFEHLKTAFSCTKDTSKGCSNCNNKSCIENEELIPYFLLFLLTAFLRLPESYEIILSSAQITLKERVYNIISSSPSRQWKLTDVADHIFMSTSTLKRKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTPSTFIKMANH
The following text describes a protein:
Function:
Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function. Palmitoylates several amino acid permeases. Palmitoylates chitin synthase CHS3, which is required for its proper export from the ER. Can palmitoylate RAS2 in vitro.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MPVKLRWPWLGIAIPTFLISFIGYGAHYFILSNFLSVPKQITFEFCLSMIWLSYYLAICTNPGRPLPNYKPPPDIWRNFCKKCQSYKPERSHHCKTCNQCVLMMDHHCPWTMNCVGFANYPHFLRFLFWIIVTTSVLFCIQAKRIYFIWQQRHLPGYFFKKSELIFLTISSPLNSFVLLTITILFLRCLFNQILNGRSQIESWDMDRLESLFNSGRLTQKLIDNTWRIYPESRSFQNKKDAEEHLTKKRPRFDELVNFPYDFDLYTNALLYLGPIHLWLWPYGVPTGDGNNFPKNGISKYEANSSLEDHILSLPWPPDGGKTNTVFNHGSSTIEMRNESGEQLIRTRLPQNGRHASREKWYNDWGESLDDFGVDVDME
The following text describes a protein:
Function:
May be a cell surface adhesion protein.
Subcellular Localization:
Secreted.
Sequence:
MDRCIYGCSVITIFFSFFFLLNASALESGHHNITGSGQINSNSVLVALLDSRYTELAELVEKALLLQTLEDAVGRHNITIFAPRNEALERDLDPDFKRFLLQPGNLKSLQTLLLSHIIPKRVGSNQWPEENSGRVKHVTLGHDQVLHLSKLKGTNGKRLVNSAVITRPDDLTRPDGLIHGIERLLIPRSVQEDFNRRRNLRSISAVLPEGAPEIDPRTNRLKKSATAVSVPAGSPPVLPIESAMAPGPSLAPAPAPGPGGAHKHFNGDAQVKDFIHTLLHYGGYNEMADILVNLTSLATEMGRLVSEGYVLTVLAPNDEAMGKLTTDQLSEPGAPEQIMYYHIIPEYQTEESMYNSVRRFGKVKYETLRFPHKVGAKEADGSVKFGSGDRSAYLFDPDIYTDGRISVQGIDGVLFPEEKEEETVKKPTGPVKKVVQPRRGKLLEVACSMLGAIGKDSYLSRC
The following text describes a protein:
Function:
Involved in the biosynthesis of 6-O-methylglucose lipopolysaccarides (MGLPs). Catalyzes the transfer of the glucose moiety from UDP-alpha-D-glucose (UDP-Glc) to the position 2 of 3-phospho-D-glycerate (3-PGA) to form glucosyl-3-phosphoglycerate (GPG).
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target; MISCELLANEOUS: The glucosyltransferase GpgS does not possess a putative nucleophile residue that could result in the formation of a glycosyl-enzyme covalent intermediate. Therefore, it is expected that the reaction would proceed through a front-side substrate-assisted SNi-type mechanism where the breaking of the glucosidic bond is stabilized by the interaction of the acceptor hydrogen atom O3 of the acceptor 3-PGA with the beta-phosphate of the nucleotide sugar.
Sequence:
MTASELVAGDLAGGRAPGALPLDTTWHRPGWTIGELEAAKAGRTISVVLPALNEEATIESVIDSISPLVDGLVDELIVLDSGSTDDTEIRAIASGARVVSREQALPEVPVRPGKGEALWRSLAATSGDIVVFIDSDLINPHPLFVPWLVGPLLTGEGIQLVKSFYRRPLQVSDVTSGVCATGGGRVTELVARPLLAALRPELGCVLQPLSGEYAASRELLTSLPFAPGYGVEIGLLIDTFDRLGLDAIAQVNLGVRAHRNRPLDELGAMSRQVIATLLSRCGIPDSGVGLTQFLPGGPDDSDYTRHTWPVSLVDRPPMKVMRPR
The following text describes a protein:
Function:
The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs. Required in motor neurons and proprioceptive neurons to ensure correct U12 intron splicing and proper levels of tmem41b mRNA. Required for the maturation of motor neuron axonal branches and dendrites.
Subcellular Localization:
Nucleus, gem. Nucleus, Cajal body. Cytoplasm. Cytoplasmic granule. Perikaryon. Cell projection, neuron projection. Cytoplasm, myofibril, sarcomere, Z line.
Domain:
The Tudor domain mediates association with dimethylarginines, which are common in snRNP proteins.
Sequence:
MANGAEDVVFCRGTGQSDDSDIWDDTALIKAYDKAVASFKNALKGEDGATPQENDNPGKKRKNNKKNKSRKRCNAAPDKEWQVGDSCYAFWSEDGNLYTATITSVDQEKGTCVVFYTDYGNEEEQNLSDLLTEPPDMDEDALKTANVKETESSTEESDRSFTPQKSGHAKHKSKSNFPMGPPSWFPSFPPGPPPPPPHFKKMDGRRGEGPGPSFPGWPPMIPLGPPMIPPPPPMSPDFGEDDEALGSMLISWYMSGYHTGYYMGLRQGRKEAAASKKSHRK
The following text describes a protein:
Function:
Trichothecene 3-O-acetyltransferase involved in self-protection against trichothecenes, mycotoxins acting as eukaryotic protein synthesis inhibitors. Its existence is surprising in a non-trichothecene producer organism which needs no self-protection again endogenic trichothecenes. The persistence of this non-essential gene may be due to a selective advantage that it may confer, like a resistance to exogenic trichothecenes.
Sequence:
MFRVKIISQKRTKSVQMLENDQLDILGQQPSLYKLYTQICSIYRVPDPSAHDHIVNTLTRGLETLAKNFQWLAGNVVNEGADEGNTGTYRIVPSDKIPLIVQDLREDLSAPTMDSLEKADFPIYMLDEKTFAPCMTINPPGNTIGMAAKSGPVFAVQANFISGGLVLTIVGQHNIMDITGQESIINLLNKSCHQKPFSDEELLIGNIDKSKSIPLFDETWEPDTTLVHEIVETSRNTSGEEKEQSCSSNSTWAYVEFSAISLQNLRILAMQTCTSGTKFVSTDDIVTAFIWKSVSRARLSRLKPETKSNLGRAVDVRKRLGLPETYPGLLVNMTFNTGSLKSLDHKSLGVLASQIRRKLDPKVFDLAYNTCALATLLSRCPDKTKVSIPQPIDTLSGIMVSSWAKVSLYDVDFNLGLGKPKSVRRPRFISLESLIYFMPRSSRGEMVVALCLRDKDWECLNADKEWTNYATHIG