lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in abiotic stress responses. May function as chaperone and contribute to prevent the formation of damaging protein aggregates.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing LEA17 display enhanced tolerance to salt stress, drought stress and osmotic shock.
Subcellular Localization:
Nucleus.
Sequence:
MASRQDRREARAEADARRAAEEIARARDERVMQAEVDARSAADEIARARADRGAATMGADTAHHAAGGGGILESVQEGAKSFVSAVGRTFGGARDTAAEKTSQTADATRDKLGEYKDYTADKARETNDSVARKTNETADASRDKLGEYKDYTADKTRETKDAVAQKASDASEATKNKLGEYKDALARKTRDAKDTTAQKATEFKDGVKATAQETRDATADTARKAKDATKDTTQTAADKARETAATHDDATDKGQGQGLLGALGNVTGAIKEKLTVSPAATQEHLGGGEERAVKERAAEKAASVYFEEKDRLTRERAAERVDKCVEKCVEGCPDATCAHRHGKM
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MVVNATLAAAAKHGMSREPAINVYQVSSSVVNPLTWQEMATLSCEHFKCNPILDSKGNPISVAAPMKLYTLMEEFSTHLERDMAQQRELMAMKFLNSKKPEIYAEKWMELIRQLATIYKPYSFYKGRYDVSIDTNTRGTSHLMNFAKYCKNLSLFLQISTAYVNGPRKGIIMEKKFSMGDTITGEKFNSENLSTSLPILNVEKEIQLAFDAIDTFQDNSLTQNLKKLGLERAEKYGWHDTYAFTKAMGEMVIDSMRGEVPVVIIRPSIIESTYKEPFSGWIQGNR
The following text describes a protein:
Function:
Necessary for male gametophyte development, as well as ovule specification and function. Involved in cell-cell communication process required during early anther development, and regulating cell division and differentiation to organize cell layers. Required for the development of high-ordered vascular strands within the leaf and a correlated control of leaf shape, size and symmetry. May regulate the CLV1-dependent CLV3-mediated signaling in meristems maintenance.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MRLLLVLFLLLHFYLQIFTSLGRVISEYQALLSLKSAIDDPQGALASWNSTNKNNLCTWSFVTCDYNNRHITSLDLSSLNLSGTLSPDIAHLRYLQNLTLAANQISGPIPIQLSAISGLRCLNLSNNVFNGSFPTQLSQLKNLQVLDLYNNNMTGDLPLAVTEMPNLRHLHLGGNFFSGAIPREYGKWEFLEYLAVSGNELEGPIPPEIGNLTKLQQLYIGYYNTYEGGLPPEIGNLSDLVRFDAANCMLSGEIPKEIGKLQKLDTLFLQVNGLSGSLIEELGNLKSLKSMDLSNNMLSGEIPTSFAQLSNLTLLNLFRNKLHGAIPEFIGDLPQLEVLQLWENNFTGSIPQGLGKNGNLVLVDLSSNKLTGNLPPDMCSGDRLQTLITLSNFLFGPIPESLGKCQSLSRIRMGENFLNGSLPKGLFGLPKLTQVELQDNLLTGEFPVTDDKIAVNLGQISLSNNHLTGSLPSSIGKFSGVQKLLLDGNKFSGPIPPEIGKLQQLSKVDFSHNKFSGPIAPEISQCKLLTFVDLSRNELSGAIPTEITGMRILNYLNLSRNHLVGSIPASIATMQSLTSVDFSYNNLTGLVPGTGQFSYFNYTSFLGNTDLCGPYLGPCKDGDANGTHQAHVKGPLSASLKLLLVIGLLVCSIAFAVAAIIKARSLKKVNESRAWRLTAFQRLDFTVDDVLDCLKEDNIIGKGGAGIVYKGSMPNGDQVAVKRLPAMSRGSSHDHGFNAEIQTLGRIRHRHIVRLLGFCSNHETNLLVYEYMPNGSLGEVLHGKKGGHLHWDTRYKIAIEAAKGLCYLHHDCSPLIVHRDVKSNNILLDSNFEAHVADFGLAKFLQDSGTSECMSAIAGSYGYIAPEYAYTLKVDEKSDVYSFGVVLLELVTGRKPVGEFGDGVDIVQWVRKMTDSNKEGVLKVLDPRLPSVPLHEVMHVFYVAMLCVEEQAIERPTMREVVQILTELPKPPNSKQGDSTVTESSPQSATSLDSPKATSKDPKDNQQPALPQSPPPDLLSI
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MVLYSSKTEPFLSTSSDMVCATEFVRYLHLIHYIGFVGAQSLNAVLVFLIITKSENLLGNYRYAMFVFTLCSMVYSMVEILVQPVGHMKGSMFVVFMHSSILNATNPLAEFLTCLHCVLSGFVASLLACQFIFRYLAVCRTHFLVHLQGINLCLLFIPSIFVFAVWHFGFFHGMPNTLEKQIFLREELQTCFNVNTTVNPFVGPMYWTKGADGQIHWNIFELISALSCFAVLIICFFTIVFCAYSIFMKMSNSIHHLSAKTLDLNKQLFRMLCIQTVIPMITMYFPVALFVTLPMFGKDIPYLGNMTSSSLAIYPIIEPIIAMTCVASFRKAIKGSIRCSVSRSTQFAIHPASSPRLTDQKQ
The following text describes a protein:
Function:
Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.
Sequence:
MYAQLCKRIQKELETDIDKSKSSTFLQILLNVCRDKFENRVQYSEKIINSESTLTDDLEEKKNVAKQKILGNVKFIGELYKLGMLVEAHLHKMLRSLFTNKSSSSTEKNCEDMECLAQLIRTCGKNLDTELGKQLMDQYFERMEKYSQSQSMFPPRIRFMLRDLIELRKNNWTPRKVALVEGPAPIQELNHDDDVLPPGLNHLRNRDRDYRNMDRSEQRDWIGKFSLNLHNLNDGFNLLSVSSPSPLLPSSYNQSSNGYGNRDHRDNGGGGGGGGNYRMHNNRNNQNNYGNNNMRYNKHNNHHHQGSGGGGMRDGGNGSHSSSYGGNSGMMSNKDLAPRFKRNLMTPPQNPVEELQMRPTPNSLLFKANMNIKPQLPISSSIGGGTIGGGKTSFNGPSLSEFPSPLTTRTLLSEQRNAGQINNSAFPAGNNSTGTGGSFGAPAGSAMSSTVVPRPGTQSDNSGGVNMMTTGRSSGGSQQPASQTISSNVMNHRHQQHTSQGPRQLGGNENGNAHLNKHYTDLHQQHHHHHQGQQNLQGPIGDHGNREMNGDRMMNHYETPSHNRQHMDPLNQSLLNPISGVTSNNSSLMLGGKLTQKEQIVKQASTDKTEKKKKDKGMSKEDHMKRVVTFVSDVMLENIKQQIEDEEQKKNACIEENEEKSDMETKDATVKEVLVEVVDKKEEQAAEPLTKPIESEPVQLIENAQIIHDKTTGQDDTVPKEKKIDEDENEAADLKGDEKTDIGSETQKDEHDATTLNNQQQEPLAEAENTAEMKERQEDDAIPAAIPESAEPSVDEKPVVKKLSLMEELVNAFCELKLPEKFMRDAMIAILNQVLDRNDAFHAKTIEFLQILNKESKLSHSAALESFKSIVNGMNEKEKTIPKITSIIASLLARAVAVNLCGLADVANFTENGQHYPLFLLVLQHLHKQLGKQPLQELFNKSKVNLMASLPECDRTKDRMAEILEDRNLNFLYPLLRVQAELWKQILSDANPQQFYKWIKENVESSCYAEPGFIVAIMTVLLKYIHQESENLKEDKKRIEKEKEILTKYCPVLNAFLNGNNDLQLTAVYAIQVYWYSIGYPKGVLLRWFQEMYELSVIEEDAFLRYKEDVTDIYPGKGKALFQVNQWLTWLAEAEDEDDDEED
The following text describes a protein:
Function:
May play a role in neural plasticity. May be involved during axon regeneration.
Subcellular Localization:
Secreted.
Sequence:
MHTVKLLCVVFSCLCAIGWASHHSHRQPCHSPQLTSGTMKVVSTGGHDLASGEFSYDSKTNKFRFVEDTTHANKTSYMDVLIHFEEGVLYEIDSKNESCKKETLQFRKHLMEIPVDATHESESYMGSPSLTEQGLRVRVWNGKFPELHAHYSLSTTSCGCLTVSGSYYGEKKDLFFSFFGVETEVDDLQVFAPPAYCEGVSFEEAPDDHSFFDLFHD
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular Localization:
Cytoplasm.
Sequence:
MATSVPHPKIVKKYTKKFKRHHSDRYHRVAENWRKQKGIDSCVRRRFRGTIPQPNIGYGSNKKTKFLNPAGYKVYLVKNVKDLDVLLLHTKSYAAEIASSVSSRKRVEIVAKAKKLGVKVTNPKGKLNLEA
The following text describes a protein:
Function:
Female meiosis-specific activator of the anaphase promoting complex/cyclosome (APC/C). Required for the completion of meiosis in oocytes. Activates the ubiquitin ligase activity and substrate specificity of APC/C and triggers the sequential degradation of mitotic cyclins in meiosis. Promotes the ubiquitination and degradation of CycA early in meiosis I and the degradation of CycB and CycB3 after egg activation. Promotes degradation of mtrm at the oocyte-to-embryo transition.
Subcellular Localization:
Cytoplasm.
Sequence:
MFVEMSVCDSPNKNSKLDKKSLTPFKKVRRKNWKQEAAYKSDTSKGQEVSYVGERFIPNRFERENIEFNLKYIGKRKERDILETGVTLTASYWRQSGFISNINRTFGIGERRLFQFSSQQGTRSRVVDNDSADSDWPCNPRARPYAIQNATHEMPGICSPVDYNMMDWSSGGMVAMSSGQDVMLWRNLDESTMVFSVESPTSLKYSPDGKHLAIGCMDRNYPVLDLWEVRSPTEFLVSYRKLFFKSMGYISCIEWSHDGKEVICGTQCGVIIVLAMPTLNTLMQLREHRHTVKKMKFAPTHKYFASSDTDGKIFIFDAVLKVRLLKLDGRSIVFDWHPWTGEDLAVAERSPASIFIFNIPRRQFVASYRRRDDRIVIKTLTYSKITGELLVNVIRRDDADLAVCEILVLASLNRVVDLMSHQDRGTLFLMWNPDGTKIATGGLDDTFSLWNFFPTYKREAILRKQEQKAKDKCSSLSLYKGIR
The following text describes a protein:
Function:
The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTVEQNVLQQHSQKHQQTLLNQLREVTGTTDVQLLQQALQVSNGDLVEAVAFLTEKNAKVPQQDEATYYQTAQITNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLEESNRAFRETGITDEEQAISRVLEASIAENKASLKRTHTEVWSDSPNPHERKRMENCPVGLKNVGNTCWFSAVIQSLFNLLEFQRLVLHYSPPARMQDLPRNQKEHRNLPFMQELRHLFSLLVGSKRKYVDPSGAVEILKDAFKSSESQQQDVSEFTHKLLDWLEDAFQIKAEEDREGEKPKNPMVELFYGRFLAVGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSAENSAKSGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPSMLYMDRYMDRNREITRIKREEIRRLKEHLTVLQQRLERYLSYGSGPKRFPLADVLQYAMEFASSKPVCTSPVEDIDTTAPPGGTIAQLPPPASAGEQPDACVSAEGSGSGLQASQQQQQRVSIHKPFTQSRVPPDLPMHPAPRHITEEELRVLESCLHRWRSEVENDTRDLQASISRIHRTIELMYSDKSMMQVPYRLHAVLVHEGQANAGHYWAYIYDRHHQRWMKYNDIAVTKSSWEELVRDSFGGYRNASAYCLMYIDDKKPFLIQEEFDKETGQMLSGLDKLPPDLKVFVEADNKLFEREMEEWDALQARKLQQEKLALAAAAAAAAAASVAVQPMSTEPCSPDNTAPSAAPQHDPEYMEQQSPSGDSKHLQEDTERAISKAAAEHDEKSPEALLNTAMMTPNMQGIIMAIGKSRSVYDKCGPEAAFFKAMKVEYTRLLRLAQEDTPPERDYRLQHVIVFFIHNEAPKKIVERTLLMQFADRNLGFDERCKSIMKVARAKLELIKPDEVNLEEYEMWHQDYRIFRETSVFLLIGLELFMKKSFVEALMYLIYAYQYNKELLAKGPYRGHDEELIAHYRRECLLKLNEYAAALFETGEEAKVNTGLSIMNDLVVPCLPLLLVDEMEEKDMVAVEDMRNRWCSYLGQEMEPNLQEKLTDFLPKLLDCSTEIKSFHEPPKLPSYSTLELFERFGRVMTSLTMGRTPADGR
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MHTTTVLQVIALLLSQRKAAAVAAGDNEHHFLDLCALIALTQRPIPELPETQQATTDYQEIQKLNISLSGTDWRKQFDKTGTPPKRAAYKPSGATEDSLRKERRPYWINAEDEIETDKGPEKILRSAGADGATQADRQRLLALLQPIAEAAASTFTEIENLKQASKALTAAAIHKKIQTATYGEQATAAADLTAAVFKAANGNPTNRKELCGDTTSASAKARTLTAFLYCICAGEQSQNAGGFKACSNAQPANADAQAALTNVHTAIQGLINVCPEPGNDKVTPDDITKLIAAVAGKTTSKAQQAFYGTFAATDCGGLSGSGLCVYYKTTTKADSKAYHNIQWKKQLSDAANDLRDQQLATQRLQGLLLQLKSLKKQAYNLRPQLEIYKKLQVTAGKSGTTQEAQAKKGDDCKQHTKNATCTENNCKWKATTEEAGTCEAKAEEQKSQGTGEGASGTSATTGCTRHGTDKTACENDKTGDKQNCAWRKGKDDEPDKETEKCRNGCFLVNNKFALMTASFASLVAF
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 3150 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MKVPLGLWKVSRGNLWSTQKRVLTMSRCLNSDAGNEAKTVREGPAFSADLYMHPEKWKGLPPQRILELYWERMARLGSEYKPNKDELNALLTTSEYSNVPVNDIKKLYHRGEQGAIDIKGGNVNRDNSLRPFMFDELPSQAQELVAQHREQRFYNRLAAYELPLLAQYRQEYKRPSPESHPVTYRYTSYVGEEHPNSRKVVLSVKTKELGLEEKSLHKFRILARSRYDHTTDIFKMSSDKFEHASQNARYLHDILQRLLAESKDLTEDDFSDVPLDTRHTIAKSLRKKKRDYEFPEHWKRPEDAPKKKFDIVDQLLSTL
The following text describes a protein:
Function:
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MEAENGEGQVQVHLKTKQEHYAVPDVPYAIDGSVSTTELNIFLNALLQSKGAEGVDFDFLVFDEYLRGRLCDHLREKAISFEDAIDIEYVERFPAPEPQDCLLHDDWVSAVKACGKWILTGCYDNTINIWTNKGKHKLTIPGHTAPIKAVDWISMDDENGRFVSTSQDQTAMLWQWNIASNAVECVSVCKGHERGVDSVCVSPDAQRFATGSWDTMLKIWSAGLDDTSEGTAKRVKESGVRTPKMTLQGHRESISAVQWMDATTLVTGSWDHTLKVWDLQLEGIKTEISTNKSIFDASYSKLNRLIVTASADKNLRLYDARTNQGSVVRNTYLGHNAWVQTVMWSNTEEFLFVSGSYDTQNKLWDCRSPKAPLYDLLGHGEKVLDIDWSNPKYIVSGGADNTVRVFKSGKATIENMETK
The following text describes a protein:
Function:
Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MATAIKLILSEEKIQEKIGVCFRDMGLLQSLSIPGTYQEKITHLGNSLKNLTCLKSLDLSRNSLICLEGIEYLTLLENLNLYYNNISSLTEVFRLHQLPELKDVDLRLNPVAKNEPDYRLFLVYIIPRLRQLDNRLVRESERKASLSHFSMEEPFELKQMSSDLLKNQSERDRHSRTKYIDSLTKKCSVMDAEDEAVLNLIAECEMDLSKPPGLASSSKKDCAVPEFHNLPGSRPLQSPKPVPRVSQENIRGYDRKKSSSKVNFLDDKLLEHSIVKSQDEVEMQRKYMPSGHFDLQLSESSGIEGSFNSPMQKKVTSAQKMLKTLATSGIIYKRKMLNRRLQSIQEENCSELLERNSILERNSRLSSSDESIFNQQIERTLESERKNDRSYSNFDRSEPDISEQTRIKNINASLKEASSSHSATQTLNKDAFKISLLDTLLDLVDKYWNGRKSLHSNEKFLYQARHVLSAVQAAAPNQEDSSIMSEKISHLILENEALQSLAEQEQQYNMRISELMLELNTALKEMDSLKKQLSNSLEENKNLKSQLLSVEQNAKHGEATALLTVQVTELQNSNQELASEIDNLKEHLEHYAKIQELTEMLQESHSSLISTNEHLLQELTQTRIRHKAEVEQLHWSYNELKKTMSQFPLSNSDLSSS
The following text describes a protein:
Function:
Embryonic developmental transcription factor. The lateral or ventral identity of a cell depends upon the concentration of this protein in its nucleus during the blastoderm stage. Acts as a morphogenetic transcription factor that specifically binds to the kappa-B-related consensus sequence 5'-GRGAAAANCC-3', located in the enhancer region of zygotic genes such as Zen, Twist, Snail and Decapentaplegic, promoting their expression. Part of a signaling pathway involving NF-kappa-B and Toll-related receptors, that functions in the apoptosis of unfit cells during cell competition. Mediates an immune response in larvae. May be part of a NF-kappa-B and Tollo signaling cascade that regulates development of the peripheral nervous system.
Miscellaneous:
MISCELLANEOUS: [Isoform A]: Nuclear localization signal at positions 335-340.
Subcellular Localization:
Cytoplasm. Nucleus. Note=In ventral regions it is first cytoplasmic, then the protein is relocalized in the nucleus. Its nuclear localization is essential to its function as a morphogen. In dorsal regions it remains cytoplasmic. Tamo negatively regulates nuclear import of dl. Emb is responsible for export of dl from the nucleus. Nuclear localization is enhanced upon microbial infection; [Isoform A]: Nucleus.
Sequence:
MFPNQNNGAAPGQGPAVDGQQSLNYNGLPAQQQQQLAQSTKNVRKKPYVKITEQPAGKALRFRYECEGRSAGSIPGVNSTPENKTYPTIEIVGYKGRAVVVVSCVTKDTPYRPHPHNLVGKEGCKKGVCTLEINSETMRAVFSNLGIQCVKKKDIEAALKAREEIRVDPFKTGFSHRFQPSSIDLNSVRLCFQVFMESEQKGRFTSPLPPVVSEPIFDKKAMSDLVICRLCSCSATVFGNTQIILLCEKVAKEDISVRFFEEKNGQSVWEAFGDFQHTDVHKQTAITFKTPRYHTLDITEPAKVFIQLRRPSDGVTSEALPFEYVPMDSGKHTFWNLHRHLKRKPDEDLFQQILRLDAKREVQPPTIEVIDLDTPKIDVQREIPSEMEFNHEESQQSEPALEQEQSVQQEQYTQEQSLQQEQYTQEQSLQQEQYLQQLEQQQSFQLEEPMQQDQELPAQQSFDQAIDHLPDHTSDHIPEDMEAADAHAEAEAHRLRSEQEKEIDTIIDEKVRELEQLDLGQQLEPRPLTANDKITEWMKSSEIEQQVHEPSPTAEADVLDSALEISKADKTLDELLETVAELDEIYTDFKVQRDTYKNTIQNELAGLQGRAPLQVEDSFDDAATYTSLQIAFKNPVLIPMDDIMPPTPPMSQCAPEDAHQHYDPVEVNSQARKPETPMRPVPPVPPAILTIQYPPEEDKLPPLPPKRIRKQDSNAENRSIEANTVQTKPSTGESPLNKRLPPAPKNPNFNTLPRQKKPGFFSKLFSRRKSKPDLAQGQENSSILDSKANSREPSIGHFNMQDPMRASLRSSKSAAPFISNPAPAKSSPVKAKKPGSKLTKPVGRSVSSVSGKRPAYLNADVVHIPLKGDSVNSLPQQQRTEGYSQSSTISVGAGLDRRTASALQLADIPISEGGMELVAIADRQSLHNLVSSIEGHFNVQLDPNLDLTEAEHFALYTSIPPLAAASEFDETSAYYAPVDAGEILTPDEVAKRLAAANGI
The following text describes a protein:
Function:
Aminotransferase; part of the gene cluster that mediates the biosynthesis of fumonisins B1 (FB1), B2 (FB2), B3 (FB3), and B4 (FB4), which are carcinogenic mycotoxins. Within the pathway, FUM8 catalyzes the release of the C-18 polyketide chain from the highly reducing polyketide synthase FUM1 by a nucleophilic attack of a carbanion, which is derived from R-carbon of alanine by decarboxylation, on the carbonyl carbon of polyketide acyl chain. The biosynthesis starts with the FUM1-catalyzed carbon chain assembly from one molecule of acetyl-CoA, eight molecules of malonyl-CoA, and two molecules of methionine (in S-adenosyl form). The C18 polyketide chain is released from the enzyme by a nucleophilic attack of a carbanion, which is derived from R-carbon of alanine by decarboxylation, on the carbonyl carbon of polyketide acyl chain. This step is catalyzed by the pyridoxal 5'-phosphate-dependent aminoacyl transferase FUM8. The resultant 3-keto intermediate is then stereospecifically reduced to a 3-hydroxyl product by reductase FUM13. Subsequent oxidations at C-10 by the cytochrome P450 monooxygenase FUM2, C-14 and C-15 by FUM6, FUM12 or FUM15, tricarballylic esterification of the hydroxyl groups on C-14 and C-15 by acyltransferase FUM14, and C-5 hydroxylation by 2-keto-glutarate-dependent dioxygenase FUM3 furnish the biosynthesis of fumonisins. The tricarballylic moieties are most likely derived from the citric acid cycle, and their addition to the carbon backbone may involve FUM7, FUM10, FUM11 and FUM14 (Probable).
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MSPAPAILALRRVYNFCLLVDEAHGFMALGKSGRGSFEWWQDCGYDCPLQEVDIMTGTMSKSLCCIGGFVSANGVYAAELERQRTLQHQNGAETLSTAVLVRILSLINKPKLIKERMTALGRKASFVADCLAQAGCDILSSYGSPVVCFPVGTIQQASRFHEEAMERGFAVACGVPPATPLWSCRVRVCIFATTSWEDILDLINMIIKVSCKLQLKGITATVFTPDTLPKQYLDDPSIAEQSIKSDASICSYVESLSKTYPGGDLEAKAPLNLAQSQEAVEASVKAFSKYGLGPSSARWFYGTFDVFIALERRLAKLYPSLQRHSGRCRAMLGTDAHTMMLSLLSACANPYTSGVMNILLIPTTASLAVQDGADLNRPRAETKIIYYEKLDNLVAKLRELPIDASKLHLTLYLQTTSHDGSSILDLPATVQMINSGMNDPNQLKGLKLILDDSGGLGKVGPHHLGYLDLMERDHGVSFLNQSLGIKLAPKTEIIVTGSFFNAFGQQGGYIISSASFIEVHTVSSKSFVFSTPPTPIQAALSGKVLEILSRGTC
The following text describes a protein:
Function:
Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
Subcellular Localization:
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the centromeres.
Sequence:
MSGYQHELPPNISKTSPAPEEAREELLQQCEAIWKQMEECQSKLTMSGPETLPETDVQLYLLMMQVKALTAEYEQWQKRTPEIISDNQDVLLAVGKEELEKIAQELEMVLSSVQAKNKKLKKDLEKEQNWLDGQQKIVDALTSRQDELKNQLTAFSEKRVYQDIAGKLYKVRAHKEELLSALGDFLEEHFPLPQEQENQSKKKKGQSGKKSVQLMTLHEILEILINKLMTTPHDPYLVLEPHHWPPYIEMLLRYGIALRHPEDPKRIRLEAFHQ
The following text describes a protein:
Function:
Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5-oxoproline.
Subcellular Localization:
Cytoplasm.
Sequence:
MSPKSKSTNKTYTIVIKLGTSSICDEKTHEPLISNLSLIVETVVKLRKLGHNVVLVSSGGIAMGLRRLDLPKRPSKLSAVQAIAAVGQGRLISLWDTLFTQLRQPIAQVLITRNDIAERSQYVNAANTISELLHFGVVPIVNENDTLSVQEIRFGDNDTLSAITAGMINADYLFLLTDVDCLYTDNPRTNPDAKPILKIHDTSMVNANVSTPGSGVGTGGMKTKLIAADLGTSSGVNVIICRGSKPSSIFDIIRQESSDNKNESVELPLHTHFVAKKQGRIRDRHFWLLHGLKSHGSLEIDRGAFEAITRTNRAGLLPVGVTKVHGHFSAHQAVTVIYNGEEIGRALVNYSSTEIDLIKGKRSKEIASILGYNETEYVAYRDYLVVHGLNSHHDSQVSSDEH
The following text describes a protein:
Function:
Mediates H(+)-dependent pyridoxine transport.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein.
Sequence:
MTQYAVPTSPDSEQDAVLPTTTVLPSTAPSPPQIVAYHRRWWIVGTFCLLGIAQGAVWNCWGPISDSARLVYGWTDGKIAMLANWGCIAFILFAPGLMYINADRLRFSVVLTALLIAVGTGLRCIPASAGIATILINAGQFLNGVAGIMLMAAPPLISSTWFPPNQRTTATAISSIFNYVGTSVGYLIGPLFVSQPHLMPNSTLHYNQTVVEDISGQIMRLMYVECGYCTAVFLAILIYFPSKPPTPPSLSAAMDRLDFRTGLKKLFRHGQFWLVCLAYCVPGGVIGGWTAVLDVILSPHGISQIDAGWLGFYGNIAGCGVGLLLGRFADYFAGHLRLIIVVMMCCATGSLTWFTIMLFGALPLTQVSLYISFILTMVSVNASIPLFLELVMETTYPIEEAVSAGVMTWGNNLFALIFLLVPLLPKVGVTWMNWAALGGVACSVPLLCVFRENYRRLHLDTGAGSEGNDETQHLINDGSISEDGKG
The following text describes a protein:
Function:
Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.
Subcellular Localization:
Nucleus.
Sequence:
MAHHREFIHPTSQSEQFPATSAADPPTYDFLQLPQNPLAQFHDMHEVVGHTQPLHPSNFMELQKWHLQQFWQQQMLELGNLADYKQHQLPLARIKRIMKLDGAAKMVSSDTPIIFAKACELFILELTVRSWLHAEQCKRLTIRRTDVAGAICHADMLNFLVDMLRPDEFQVFIRQPQMLQQHMMHRQQSYPNHILSEPPPPLVSLRNLDRHLNCWEQNCEASRDHSRTVLMEGKTPCNVHSCLVKS
The following text describes a protein:
Function:
Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.
Sequence:
MADAEEPEKKRRRIEDLTDKMAVDGGHRISGCSWDGRWNHVRKFLERPGPFTHPDFEPSPESLQFLLETCKILVIGAGGLGCELLKNLALSGFRLIDVVDMDIIDVSNLNRQFLFRPNDVGRPKAEVAAEFINSRIPGCKVLPHFKKIQDFDDSFYRQFHIIVCGLDSIIARRWMNGMLISILSYDEGVLDPSSIIPLIDGGTEGFKGNARVILPGMTACIDCTLELYPPQINFPMCTIASMPRLPEHCIEYVRILQWPKETPFGDTSLDGDNPEHIQWVFERSQERAAEFSIPGVTYRLTQGVVKRIIPAVASTNAVIAAACATEVFKIATSAYIPLNNYLVFNDVDGLYTHAFEAERKENCTACSQVPQDLQFPPSAKLQEILEYLTENSSLQMKSPAITTVLEGKNKTLYLQSIKSIEERTRPNLCKTLKGNTFLLTVFSLVSSLRAQCRRSCVLFCHRAGLVRRPGTSRSRRHHAADRSLQTQLHRLSKMTSSDPQTG
The following text describes a protein:
Function:
Probable divalent metal transporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAGSSSVQPQFIASTGNRSFSNAPLIENSDPEQIIVPDRKSWKNLFAYMGPGFLVSIAYIDPGNFETDLQSGAQYKYELLWIILVASCAALIIQSLAANLGVVTGKHLAEHCRNEYPRIPNFILWVLAEIAIVACDIPEVIGTAFALNMLFKIPVWIGVLLTGLSTLVLLALQQYGVRKLELFIAFLVCTIAGCFFAELGYAKPDAKEVLKGLFVPQLKGNGAAGLAISLLGAMVMPHNLFLHSALVLSRKIPRSMHGIKDACRFYMIESGFALVLAFLINVSIISVSGAVCNSPNINAQDQENCKDLDLNKASFLLENVLGSWSSKLFAIALLASGQSSTITGTYAGQYVMQGFLDLRLTPWLRNFLTRSLAIVPSLIVAIIGGSSGAGKLIIIASMILSFELPFALVPLLKFTSSKTKMGIYANSTTISSITWVIGFLIMAINIYYLASSFIKILLHGHLKLVAAIFLGIFGFLGMAVYLAGVAYLVLRRNKEATHLVALTSENPQIANESGNEGVYSLPREDIACMQLPQRRSNANDL
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum.
Sequence:
MAHTNTSSVLPGLYLELSRHGKSGEYDRALKVCDKILHEFPTEEKALQCKVVSHIQLGNFKDAVDVINKNAKNIGDVTFEKAYCLYRLNDIKEAWKLINSTASQSFKVKELKAQVLYRLENYQECFEVYKDLIKNSEDEYEEERETNLAAVVACLTAQLEQEVKGAPELREHTYELCYNKACILLGLSKYADSLKKLLQAEELCKKTLEENDDPEEEIEDELAIVRTQLGYTKQKLGHSDQAMKLYNLVLKQRPSDNAIAAVAANNIVTVNKDQNVFDSKKKMKMAVSEGLESKLTSQQRRAIALNHCLLLYHTGQAEQCGKAIAAFEKNFTSAGDEAILLKAAAVHCKEKQLEKAVQLLKDYAVRNPSRSQAISFTLAQLLLSQGHINDCCDILKSLGNTTYRLGVVSVPLEFIRVHFASITPACPCLLTSRGGYLLQPRSSELNLVTRESAKFHLANGRVQEAANMLEELRKADPHDPKILAQLISAYSAFDPKKAKQVSMDLPPAEEITRQVDVDTLETTSWTMGVRYVKKVTKAEASPASRAQDIVKKKKKKKKGKLPKNFDPNVDPDPERWLPRHERSTYKKRKDRRGAASGIGKGTQGAVGSASEVDATQRTTQLQSPAPGSQPSPGAQPQLGPRQQRPLPAQKKKKKKGGRW
The following text describes a protein:
Function:
May play a role in membrane trafficking.
Miscellaneous:
MISCELLANEOUS: Present with 4280 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=More enriched in the cortical endoplasmic reticulum (ER) that is closely apposed to the cell membrane than in the perinuclear ER or internal ER tubules that connect the nucleus to the cortical ER.
Domain:
The C-terminal C2 domain shows Ca(2+)-dependent phospholipid binding. It binds to phosphatidylserine, phosphatidylinositol and various phosphoinositides. The other C2 domains do not retain all 5 conserved Asp residues found in calcium-binding C2 domains.
Sequence:
MTGIKAQVHPPPDSTLFHEEEKKKVGGNLPQKVINQQERGSDHAPSGHHQYHQLINHDANDTKTSNSVSDVSKGQKTADSNPEGKKQSSKDIFVASSAQKTNQLPGPNPQGSIGAVPLEGLRPKEFRSAPSRKPNKFDTSITKPGVLDDLGKLDEKDIKEKFHLDSDDKLFPWQNVGEFHASGKGSPNTKMSRVIKAYILENFYNDWYCNIATVLGTCFFSWLFAYIGFSWWSMIFIFLGTATVYNAEYTRFNRNIRDDLKRVTVEETLSDRVESTTWLNSFLSKFWVIYMPVLSQQVKDNVNPQLAGVAPGYGIDALAIDEFTLGSKAPTIKGIKSYTKTGKNTVEMDWSFAFTPSDVSDMTATEAREKINPKISLGVTLGKSFVSKTMPILVEDINVAGKMRIKVEFGKAFPNIKIVSLQLLEPPLIDFALKPIGGDTLGLDVMSFLPGLKSFVKNIINSNIGPMLFPPNHLDINVEDIMAAQSKEAIGVLAVTIASADSLKGSDFITNTVDPYIVMTTEDAVPGTDEEVRTSIKSNVKNPRWNETKYLLLNTLEQKLNLKCFDFNDVRKDTVIGDLQLDLADLLQNPVLDNQTAELRSGTKSKGILHYSLHWFPVKEDKSEEKAVERAEAKAKGKKEDENEDTTEKEEDENEESSQTDVGIAKITLQKVKYLDTTSSMTGSLSPCAELFIDGQKVKSYRTLRRINEPSWNETIEVLVPSKSNSKFVLKIFDDRMNGKALICEYSSSLDDIMTTLDTAQEFVKGSPQGDIYLDVSWKSIEMTGAFAAANSVSEPIGCIKLDVKDAIIKGDLSGVGDVDPYYTVSLNRRVLYKSIYHSDTDHPIFDNSTYVPIFSPNQILTLEFHDYQKIGKDRFIGSVQIPTSNVFKKDPKSGKYVGNNGKEEISKLKLKDHEHKVTESIVNVSTTFIPINLVYSPEELVNVEKLEKELKEKKKKFEATQEENEQEMEKNPKEWEVAEIEDPFDSDEKKINRKAKLSLNELIKQKSGILSMQILEGTLSPSSAYLEILADDISYPVFICMKPSQGKLNSEMANIFIRDLNYSKLHFRVSKKHIAKDSDDVISETSYSTLKLLKQAYEEPMWLNFNGSKMKVRFLYTPTSVKLPSSESVEDTGYLNIKLISGHGLKSADRNGYSDPFVHIFVNDKKVFKSNIKKKTLDPVWNEDAKIPILSRSKNQVIFNVLDWDRAGDNDDLGQASLDVSSLEVGKTYNWNLNLNTQGSIKLQGSFNPEYIKPSFDIVKGGITDKPMKIASGAAHATVGIAGTGIGAATGVATGGLKKGGHLLKSLGGNPMKRSKSSNGNESNGAKKSSEKKSFDRRSPSNLNSTSVTPRASLDYDPSVPNTSYAPVQSASPVVKPTDNTSSSSNKKDTPSSNSRGHSRASSFARTLAPHGTYNGFITVVAAENVAKHVQIKISLTQGGRLKHIYKTKSQKANNDGVAVFDEECSFKASPEANLVLGAISHQRLSRDKDLGIAQINLGDPQIQQDGQISVKLGDGHLIVKINYGKDKNGQVPPVPEVPQEYTQ