lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.
Subcellular Localization:
Cytoplasm. Mitochondrion intermembrane space.
Domain:
The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation; The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters; The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.
Sequence:
MALQGNVAILTRQQDAAVAVEQFKQANPQVADVTLLSVAEGSDVGQTVANSAACKDGAFDAVVSFNEQTEQLGAELAAVLPLLKAGGALQLHVANVQEDKKNAVLMALMIGGLVDTSDKAGASAFYPQFSGAVCFSCKKQAFESAAIPLAKKFSTAQPIKKWTVLADDFGGEDEQDDDIIDEDTLLDDTDEVLQAAKADCDEKVGGKKRACKNCTCGLKDEEDKPVMSEKDLNQLVSGCGNCFKGDAFRCGSCPFLGKPAFKPGMEKVLLNLDDADDI
The following text describes a protein:
Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MSEYEIDVPLFFKRIQRLLDLWNDPSHSEEYFHGIDSLLVVTGTENIENPYQKSAALHTWLLGYEFPQTLILFTKTKVTFLSSSKKITMLEQLSQGSSGSSINLEFLKRTKNPEENLKLFQQVIEAVSATNKKVGHFPKDSLDGKFVNEWKAALEQAKAEFEYVDVSLPVAVAMSVKDDVELPIVKTASRASTGVMTRYFADQLSKFIDEGKKISNSRFSDLIEQKIDDESFFQQKALHLGNMDMDQLEWCYTPIVQSGGSYDLKPSAISNDKLLHGGVVLCSLGLRYKSYCSNIGRTYLFDPNADQLKYYNFLVQLQTKVLELCTHGAVIKEIYAKAVEYVRSKYPELESHFVRNLGAGIGIEFRESAYLINAKNPRKLESGMTVNLSVGFANLENSKAKTAEGKVYSLLLIDTIQITKDAPLVFTESPKSHADISYYFGEDTTAEKEQTTRKPTRTTATISSHKGKTRDVDDSAEKRRIEHQKQLAAKKQTEGLRRFSDGSAHNTDEQKTIVKRYESYKRDTQLPHAIANLQILVDTRAQSIILPIFGRPVPFHISTLKNVSKNDEGDYVYIRLNFITPGQVGGKKDEQPFEDQNAEFIRSFIFRSAEGSRLSHIFKEIQDMKKAATKREAERKQFADVIEQDKLIEMKSKRPAHLNDVFVRPALDGKRLPGFLEVHQNGIRYQSPLRSDSHIDLLFSNMKHLFFQPCEGELIVLIHVHLKAPIMVGKRKTQDLQFYREVSDMQFDETGNRKRKYMYGDEDELEQEQEERRRRSQLDREFRAFAEKIAEASDNRIELDIPFRELAFSGVPFRANVLLQPTTDCLVQLTDTPFTVITLSEIEIAHLERVQFGLKNFDLVFVFKDFHRAPVHINTIPMDQLDNVKEWLDSCDICFYEGPLNLNWATIMKTVNDDPVAFFEEGGWDFLSTGDDEEAGESEEEVSEYEASGSDFDESEESEDYSDYEGEDEDSESEMEDEEESGEDWDELERKARQEDAKHDRGDERPMKRRR
The following text describes a protein:
Function:
Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. The cotransport has a Na(+):Pi stoichiometry of 3:1 and is electrogenic.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein.
Sequence:
MLSYRRESPAMPRCPVRGGRVVHGTPFAYCPSPQALHRLPGAHACPFAVGAVSCPDHGFLCPGSPGRLVESRERYELDALPWQGPRLGLEELQKPELGCWVRVQSICVSLLKVPLMFGFLYLFVCSLDVLSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVRSAIPIIMGSNIGTSVTNTIVALMQAGDRSEFKRAFAGATVHDCFNWLSVLVLLPLEVVSGYLHHVTRLVVATFNIRSGKDAPDLLKIITEPFTKLIIQLDKSVITGIATGDESLRNRSLIRMWCGPAPPQTAAGGVGVPPNCTASGHCSSNGIGILHNVTRQKCEHLFTDTPLPDLAVGLVLLAGSLVVLCTCLILLVKILNSLLKGQVAKAIQKVINTDLPHPFSWLTGYFAMVVGAGMTFVVQSSSVFTSAITPLIGLGVISIERAYPLTLGSNIGTTTTAILAALASPGDKLASSFQIALCHFFFNISGILLWYPLPFTRLPIRMAKALGERTAKYRWFAVLYLIICFLLLPSLIFGISMAGWRVLVGVGAPFLGLLFFVGLVNVLQARSPGRLPKWLQSWDFLPAWMHSLQPLDSLITRATLCCTDRCRSPEGWDEREAAARDKARLGLDNPVLSYPEEMPSPALRVGSPHLTPHSATRL
The following text describes a protein:
Function:
Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).
Sequence:
MGSPARTSFQEGLRLFLYSPLEELRIHADSLRKQRYPQNTITYVLDANPNYTNICKIDCAFCAFYRKPRSSDAYLLSFDEFRQLMQRYVQAGIKTVLLQGGVHPQIGIDYLETLVSITKKEFPSLHPHFFSAVEIAHAAQISGISTEQALERLWEAGQRTIPGGGAEILSERIRKQISPKKMGPDGWIQFHKLAHRLGFRSTATMMFGHVESPEDILLHLQTLRDAQDENPGFFSFIPWSYKPNNTALGRRVPHQASPELYYRILAVARIFLDNFDHIAASWFGEGKEEGVKGLFYGADDFGGTILDESVHKCTGWDLQSSEKEICAMLLQAGFTPVERDTFYRPLSLAR
The following text describes a protein:
Function:
Controls the pigmentation pattern of the adult cuticle and larval mouth parts.
Subcellular Localization:
Secreted.
Sequence:
MYGGMLLMVACLVAAGSVSGTQKLQERYSWQQLDFVFPNQRLKQQALARGDYVPTNGLPVGIERWENKLFVSVPRWKDGIPSTLNYIDMNQTPSGSPALIPYPDWSSNVAGDCANGLSTVYRIKADKCGRLWALDTGTVGIGNTTQQLCPYALNVWDLKTNRRLRRYELRPEDTNANTFIANIAIDMGRSCDDTFAYMSDELGYGLIVYSFEQNKSWRFAHSFFFPDPLRGDFNVAGLNFQWGEEGIFGMSLTPPQADGFRTLYFSPLASHREFTVSTRILRDETKVEESFHDFQYLKERGPNSHTTSRVMSETGLQLFNLIDQNAVGCWHSSLPYSPEYHGVVDRDDVELVFPADVKIDDEETVWVISDRMPVFLIADLDYSDVNFRIFSAPLSTLVAGTVCDVQAGQFGAIQPKFGGDAADLSTTYNTDTTLLPTTYSQPLSGGYTPSLSFAPTVAPQVHKFTQGYDTPTSHMYSTQSYPTTAKAYAYNKYHGVEFHAHGAPHHGHGYHHGPQHGHDEQEQQGGYSGHRGYWNGGHKKQDSWKQFFY
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
Subcellular Localization:
Peroxisome membrane; Single-pass membrane protein.
Sequence:
MREELVEMAAKFLLHPTVRRTPVSYRRSFLEKKGLTSDEIDEAFHRVPDTPSSLTFGQDINSNQDVQSNPFASFRLQDTEQSSQPLAASMLTASPPSRFSWSNAIFSLVLLILSGAGTSMLLKKFFLPRLKSWICKVVLEEDDDKGRNSNLSLSKEAIEAAKAAAAASVDAAKASLEILQSKKEEARHLDVLVRCLGTHVAELRSITTTIRRLEGTREAALRKLQEQYIQHASQNGPDSKLPETSTVHTDHPGNFVSNSTKFKPSGISNFDSSVRPSSTPLRASAGQHPKSYMEILAMIQRGEKPPGIKDIDDSPPNPDQPLPNPSITPRIKPWEMAQSQNKFGYTRDKGSAQLNGENAQPWWRRDNTNAREIEAGTGNGMRPISYGLRTEKQLVLQS
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system for glutamine; probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MEHYLLTAKLLLRGCGYTLLITAISLVCGFVLGWGIGTVNSRYFPCRISKFLGNFYVVAVRGTPLFIQILIVYFGLPSLIKVNLSPLVAGLIALTLNSAAYLAENVRAGINALPVQQWEAAKVLGYTGPQIFLHILYPQVFKNILPSLTNEFVSLIKESSILMVVGVPELTKVTKDIVARELNPMEMYLICAGLYLIMTSAFSYFARLSEKESA
The following text describes a protein:
Function:
Probable SUMO E3 ligase that may regulate Pi starvation responses.
Subcellular Localization:
Nucleus.
Sequence:
MEPESADDAALAGCKDKLKHFRIKELKDVLHLLGLSKQGKKQELVDKILTILSDQQDQVSQLNGLTKKPAVEKETVLKIVDETFRKLHSPANSAAASPNQIDSGQSVKPKKKLNGSAQKDVNVRCPCGSSIANGSMIKCDNPQCNVWQHVGYVIISEKSAESVPQELPSSFYCDICRINKADPFWVTINHPLLPTSIAPSKIATDGSYTIQYLEKTFPLSRANREMLQKAEYDIQVWCILLDDQVPFRMQWPLHSDMQINGVQVRVVNRQPTQQLGANGRDDGPVLTEYCKEGPNKIVLSRSDSRMFSLGVRIAKRRSLQEVLNLVPKEHDGEKFDHALARVRRCVGGGAEADNADSDSDIEVVADRVSVNLRCPMTGSRIKIAGRFKPCVHMGCFDLEAFVELNQRSRKWQCPICLKNYSLDDIIIDPYFNRITSLIQSCEDDVSEIDVKPDGSWRVKGGAELKDLTRWHLPDGALSVATNIGSKINTSIVKHEIKEESLSDQLGSRIKLGIRKNNNGKWEITKRGDVNSTQSSDGDHAEHFKNGNFITPTSNNDHEDTEDLEPGQYDYPMSNVHDLDSSPIDEHVPAVSREQDIIVLSDSDDDNVTVLSPNALNSSSADDTGVPFTPNPPETKGTSEEQPGGGLDEASYLMFSEDFDDLGQLSFWQYPSNPQDHPGLQLTNNLGEVQNNTANHQPLHEPVAAAANLLEHGHNNCIDESQASIASNCVTAKKASQKRRNPEDEITALDASAMDDDLPGERPGGPLSPARQQRSVRPRLVLAIDSDSE
The following text describes a protein:
Function:
Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures. Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (By similarity). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation. Also recognizes and binds acetylated non-histone proteins, such as STAT3. Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin. In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (By similarity). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Note=Detected on chromatin and nucleosomes.
Domain:
The first bromo domain specifically recognizes histone H4 acetylated at 'Lys-12' (H4K12ac) (By similarity). It also specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (By similarity). The second bromo domain recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively) (By similarity).
Sequence:
MLQNVTPHKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLAPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSITSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVSAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTALPPGLTKSSSESSSEESSSESSSEEEEEEEEDEDEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRIGIDEDDKGPRAPRPPQPKKSKKAGGGGSNATTLSHPGFGTSGGSSNKLPKKSQKTAPPVLPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIRKPVGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKASEKTESSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
The following text describes a protein:
Function:
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
Sequence:
MAETIEVLVAGGQADPGPPLGPELGPTPVDVQAVVQEINDQTEAFDGTEVPVTIEYEDDGSFSIEVGVPPTAALVKDEAGFDTGSGEPQENFVADLSIEQLKTIAEQKKPDLLAYDARNAAKEVAGTCASLGVTIEGEDARTFNERVDDGDYDDVLGDELAAA
The following text describes a protein:
Function:
Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH. Required for hyphal development.
Sequence:
MRRAVSKILPTPKLFNDSAHFHSNFRLEYNSVDDFYVQLDNPHKVWLPGEEISGQVVLISKKNLANIVITLSLVGFIKINASSHSKLRPLKHTLFDYTIKIYGKDEEEQTDSAEFSNGLLKGEHVFPFIVKLPNKRVYTSIDFGKGSINYILKAAIGNSSSYVIPASPDNASTSSLTKKKILQNPSHTSEKVISLVNPIDVSLLPRPKPKRLILKDPRTSSNKKLSRTQTSTSTINTMSSNEHDHSLPEGATPEDSDHKSLKSIPVPTIKAILEVPQRGYLRGESIPIKLSINHLRKIQDFNGIIITFVRVCRLDNGPDGVVESFRKDLQQLILPLYVDPVTFQSEINSSLRVPADAFPTILGCPLVSFQYFVEVLINLSGKSIALDSDVDARAKANPQATKSSSDKFKFNFDSTQTERSTYINTDSYKRSKKFLQLTTEIYIGTHRSSTQEEQAPQAEEVASRRSSSMASNSNSSPAVFSTSSPHSPVEHQYAGAINSIPESVAVSNFTPPYENVVPSYVPPEFVSHLQNQSELSEKERMRQHESSLLPSAPPDDEQPSPVNMTSNQQPFSFFTYQNTNTSPPVPLDDDLYQEPVDSAPNYLNVNNDRLIVPQDNNSNSET
The following text describes a protein:
Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins.
Sequence:
MRYRTLVSPDLDRAISRRTSWPCAAMRGSSQKDLAVFDFSEEEAAVEAAAGMFTAKFQSRLRPKMDDAVYKYHLLESYTSGWTLKGDITSGLRIDMHNRDNGRDPCAVDVPEQGLALNNEKAELDEIMASSTSYDEHGQMHPDEFEDFSNQMGIKIFPDYVIHGGISYGESQVVFSADCIKIKCSDAIGSDEKFSSEWAVADIVHIVCRWSGSVTTASVKLCLGENDVTKNEKHHNDSDLPVGFPEVRFSVNDMCWMEREQRIRNLAARYEHIWNASFGDMVCKNDLMDSNASRDFFAIIAGSLEDVIYPKGDPDAVSISKRDIEFLQPETFINDTIIDFYIKYLENKIQPDQKHRFHFFNSFFYRKLVGKDHGGVSEGREAFLRVRRWTQKVNIFDKEYIFIPVNFSLHWSLLVICHPGEVANLEDNEIESDKVPCILHMDSIKGCHNGLKNIIQSYIWEEWKERNPETTEDDSWKFLKLRFVSPEPPQQENSFDCGLFLLHYVELFLKEVPVNFDPFKITRFSSFLGAKWFPPVEASLKRSVIRKLIYEILNDHSEKIDPSTCSIGCPSTSGHPEDNTERDQHVELLSAHCSPAMGVMGGAICQDTEDGEKLDAVEDSQEADTTKAEHRVCEGSQKICASKADCQIVDGREINTNANEVEATDCQVLSATGAADREDGGRELDTNEAGEDGEDCGETTSNAVRQDNKSSVIHITEVESCDGSCQVNQPSLEATIITVDETPSDDNDDVRVTCKKPVQKPRKRGKVMIPEGRRVRTRSMTKEQHNDT
The following text describes a protein:
Function:
May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.
Subcellular Localization:
Nucleus.
Sequence:
MGHGKSDRPFLSAAEHSGVYGAHSASSGKAGALEQASFHPVSYDCCAISFQPWSVPVCSPDCGIAFELTNLIPFLRKFSSVHPVTGKRFDLDNVVRLNLHKNQHGRFHDPVSFKEFGQHSHLVAIRQSGNVFLWDTVQRLNLKPKYMKDLVTDQAFTKSDIITVQDPEHPEHRNPSEMHHVKNALKLTQADKGIDSSQQINMGAIGSTHKLLSTLRETTQPDMHTASASSSTSASKHTTTAYSRNKASGSSTGMTAASFTSSSLTPRTAIERVILDDEEVMFSHIKSRPSSKAYVRLSTNFGALNLELHCGKAPKTCFNFLQLCKHGKYDDTLFHRNIPGFMIQGGDPTGTGRGGSSIWNSNFRDEFNEPGAFKHDTRGVLSMANKGKDTNASQFFITYRGVPHLDGKHTVFGRLVDGDKDATLTKMEQVPSEQGTDRPLKKIQIQDVLVTEDPFEQYQLRQKQSAKANDPTDPEYQRRMEKRKRRQNDRTTWLGTELPTNHPEAQQKQSETKIDNLLVGSWSVGKYLNSTGRPRTKTIQAHPARKEHDESAAKKTKTNTNAIAIANANANANAGFGDFSAW
The following text describes a protein:
Function:
Siderocalin-like lipocalin tightly binding a variety of bacterial ferric siderophores, also binds long-chain unsaturated fatty acids such as linoleic acid, oleic acid, arachidonic acid and, with a lower affinity, long chain saturated fatty acids such as steraic acid. May act as an antibacterial factor, through dual ligand specificity, both as a siderophore-sequestrating molecule and a lysophosphatidic acid (LPA) sensor.
Miscellaneous:
MISCELLANEOUS: Developmentally regulated in chick embryo.
Subcellular Localization:
Secreted.
Sequence:
MRTLALSLALALLCLLHTEAAATVPDRSEVAGKWYIVALASNTDFFLREKGKMKMVMARISFLGEDELEVSYAAPSPKGCRKWETTFKKTSDDGELYYSEEAEKTVEVLDTDYKSYAVIFATRVKDGRTLHMMRLYSRSREVSPTAMAIFRKLARERNYTDEMVAVLPSQEECSVDEV
The following text describes a protein:
Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Sequence:
MSAQSLLHSVFSCSSPASGGAASAKGFSKRKLRQTRSLDPALIGGCGGEAGAEGGSRGATGGRLCSPLAPAEGLGPRSASSPRGPPPRANRLPPPRPLCSSFSTPSTPQEKSPSGSFHFDYEVSLGRSGLKKSMAWDLPSVLSGPGSGRSAILCSSGGGPNGIFASPRRWLQQRKFQSPPNSHGQPYIVWKSEGDFTWNSMSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDCDLSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDREFIPQAFGMPLSQVIANDRAYKLKQDSQRDEQKDTSDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQLSLPAEAQNKKEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGVDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHANDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLRSEVSFSMGGRHSSTDSNKASSGDLSPYDNNSPVLSERSLLAMQEDAASGGSEKVYKGPEQYVLVGHLPSSKSRESSPGPRLGKDMSEEPFNIWGTWHSTLKSGPKDPGMTGSYGDIFESSSLRPGPCSLSQGNLSPNWPRWQGSPTELDSGTQVIRRTQTTATIVECRAHPPVSRVCNTSHIQGGSRRAKLATPRAEQYLTLSSAEDLTEGQLDVAWPQSRAKPLHQRPQESVRHDKRPPPPYPGPGKQALVSSHQPAESQLWRPQRPEEDSGTALQEGSQTAEREHQAAQQKRSSAYSSPTSDQNSKTLGEPNWLDWQRERWQIWELLSTDNPDALPETLV
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MSHLFFNLNALWFQLCGLSNCGFHIDSDQFFVVFEWNSIKRKMELYLNTISPTRDKASMCLLCYALINYLPLKCPQISYPQMAGMIPSRLPLPFDTTQEEPVYVNAKQYHGILRRRQYRAKLGAENKLIKDRKPYLHESRHHHAVRRPRGSGGRFLSKDQKESKFTSLNDESNVKSTARVSSAIDLPNSEVCQLKDHRDTGSTTSCSKTTQTTTSSDAIPVSKFRFFGQPWHVMTTCDPSCDVRYSGDIRHLSLPGER
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MNKFSREAGEVVLLRAITKYSSQQGTLFFTSLRLVWVQSGYSEPSLHLHISEIKNQFISTPKSAKALLRLSVRDSIKNALQEFVFEFTHPTNARSDLNSFRDKIAATANLTAPTLPVSASNGSNTTSPTNGTSPINGTSPTMTGLKVNPDGTITNDPLSSQPAQVEEKAETKYLSKLKQPSLSEQQIKQRVILLQSNKELRELYEQMVNKDRVISESDFWESRKSMLKNDSTRSEKQHTGMPSNLLADVRPSSETPNAVHYRFTPTVIHQIFIQHPSVEKAYKANVPLKISEQNFWKKYVQSKYFYRDRSSANAPPVDDDLFSKYETDEQNKIRILKRKLIDINPLVDLSSTDGFDTDVHSGYGVLLDQSQDPNKLEKALPLLRKFNRHSALVLGSKDLLTNNSINIEKDQKNLKKTKKDENSTSTPTTTTTTTNTTNTTNTTTTTTTNNTTIKDPNLYNGDDEENISVEQMEKILENHKKLVNQHIIIDDLQEENSQTLTLLKISDQKRYFEGHSTNNILSDKEKSQLIDILDFDYKNWQPNLPQVFYQTHSSSSILQEPNISVHSEIFEPYNKAAINSKEEYNLPESSFKRDLFQSFHHCNELLRHFWATTFTLGRGAPPTSQQIDKNNKISSAIALQYDKIEEKKKMLISQNKVNQSSLFTPILESLHKAIEKKESQTNQYTFKNNNNNFHTIS
The following text describes a protein:
Function:
The function of the small subunit is not yet clear.
Subcellular Localization:
Nucleus.
Sequence:
MPVPMPMERKQASYSNLDERYGIQGEKYQGQQYSHIYFTRLHHMRNLLHALVPSWKPQLPVTTVLGLEEGKDCIIVGTLYKHMKLKPSILDEYSKERSAIPLVKPHNFMHPDDHLVLEDESGRVTLAGAIPPAAFVTGVVVALHGKETSAGNFLVEDVLEAGLPPQTALSSADEDKYVVFVSGLSVGSGTFNPLQFQLLIDHITGHLGDENEQTIASNIVRVVVAGNSVHIAPRFVNGQTVASKDQSRIAEPIKELDIMLTQLVASLPVDVMPGCQDPANFSLPQQPLHRCLFSGASTYNTFSSCSNPHQFELDSVQFLGTSGQNIDDLYKYSDAKDKLEFMERTLRWRHLAPTAPNSLGCYPYTDKDPFLIESCPHVYFVGNQDKYETRLLEGPEKQKVRLICIPRFSESGVAVMLNLRNLECSTLSFSTSFDA
The following text describes a protein:
Function:
Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLDRLWEVRQALPLYLLVSTLGLAISCCFTLICPHVCRLIPALTTYGKAADQQEDNSLVEKISVPKKWFKHFYAIGLLTLFICLHTVHSLIYNPNYLHPVVLKILATLTRSYSIPPITPSTSILALLLISLHVARRLYETIFVSVYSDSRMNLFHYAVGIVHYIILPISIMCETQGVASKLPQLHVSIDDISLTQWAGAVLFWICNWKQHQLAEQIANTRKGPRGLIRNYAYGICFGGWFNLVSCPHFLFEICIYLSLFLVIPDAYVYRFIIMFVCINQTFAALITHSWYHKTFPKYPKSRKALIPYVL
The following text describes a protein:
Function:
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Sequence:
MIVELSHEFLRKEILKVGAHPASLEIFERKAQIIPLKIFNISSPTANVIKQEMLSLGGDVVVHKNVVDCKIEKSDVILLGTKKHYELFIKKLENNKYFEIPLVLQELKEYLLKQKPEKIVSPWGRVLNLSRTLVMGIINVTPDSFYSGSRKMQINEVLKTVEDMVINGVDIIDIGGQSTRPGAEPVSIDEEMSRVIPAIESIRKSYPDVVISVDTYYSKVAELAVDRGADMINDISAFRFDNDLVKIVAKYKVPYILMHMKGTPKDMQKNPYYDDVVREIMEFFEERINYAKENGVDPEKIIVDPGIGFGKRYEDNLEIMARLKEFKSLRKPILIGASRKSFIGKALSDLPPEERLEGTLGITALCVLNDVDIVRVHDVKENKRVIKVLEEIKCIRSSSL
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element.
Subcellular Localization:
Nucleus.
Sequence:
MCDYFLQRMDQGDHHHHHQAGDLTDVVRAGGAMHQAAVAELPSADTGWQLPAEPAAGACLFPPPQPSSSDCDGFADAFAGLPDPFASDFRTSSSSGVGLCPADDFFDFEAPAAAAAGGGARRGGGVLAGAQMPALSPREIRPYPVTMGGDTVKIGAPTMMPGLAVGPPCCAFDAVAGMQMPSPHAHGGGIKRRKNQARKVVCIPAPAPSSAGGRTTGEVVPSDLWAWRKYGQKPIKGSPYPRGYYRCSSSKGCPARKQVERSRTDPSLLVITYNSEHNHPWPTQRNALAGSTRSHHAKSGKNSSSHSLQKPNLKAEPEHHQASEAVPSYATTATAATTTSTTTTATTSTTSNSTPPETVAAVKEEAMVGSEVEKGTDHDASVLLDHGDLMQQMFSQSYYRPKIPEASGGHHADDFFADLAELESDPMSLIFPGGDPGKKGRMSSESLGMGTDPLFNMLDWGASATDVAATSAGSSFEQDEEWLA
The following text describes a protein:
Function:
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.
Subcellular Localization:
Cleavage furrow. Cytoplasm, cytoskeleton. Midbody.
Sequence:
MALLTLHRAPSICTTPDEPIPRRGRLQKRESFALVKGAVLLVEEEEREGLQEETVSPRLGPRHGGQASDTQRRHLHAMISLLRPEDTVKLAVRLESARPVRVRYLLIIGTLDNKEESLLLGMDFPSLNSDECTIGLVLPIWSDTQVYLDGDGGFSVTSAEVTRIFKPVSIQTMWSVLQALHGCCERAVRGAVIPSSGLEWAQFYKQNVESDQLCLNEWGAMTGLESVRKDTGGRSSSNRESVEREIKAQLRDIMRTEDLENITSKQVRTSLESRIGIDMKDYKEYIDNEMMVTMAQMDKPSRILDYLYLGSEWNAANFEELQKNNVGYILNVTMEIDNFFPECFTYMNIRVYDVEATDLLSHWNNTYMFINEARKSGQAVLVHCKMGVSRSASTVIAFLMKQQGWTLDQALNHVRERRPIVQPNEGFLKQLNTYSGILNASKQRHSALWRRKSKADARQPSVHNEQATGDENEEKEEEEEESQSPDEESSEEDTDVFEQMCENVLDTGEAESATSNQFLSIQESDKVSSSPSRSGRMDLFSLMQSIQLDDEDRGMDKEMSVCQRLSPGQRRRSQGRRGLTYQRAHVDASPEPSSRQTQHTNNDEAGL
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular Localization:
Mitochondrion.
Sequence:
MAKIKPQALLQQSKKKKGPSRISITNIVIYTLAVLLLVFVLFSAYRRWTHRSEIPTHNGRSVLEDAAFPGMKNVDLPRFATLDTGKGSVTIELFKDTAPNVVDQFMKFCQDGYFKGFLFSRVVKHFVIQAGDSAEFDAVKDWALDRKNIDTSLKHEEFMVGTPKAKNEQGGFEFFIVSAQIKDLNEKLTVFGRVSKGQDVVQEIEEVETDDQYQPKSPIEIMSVTLLQDM
The following text describes a protein:
Function:
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Sequence:
MKNIKQLVLKLLHNPDSSVRRQAAEELALTDERAIYPLIKALRDENTAVQEAAAQALISIGSKDNFFLINPGEVVTYMVVPLLREEDVYLRNIAILIIKEVGHKAPELLYKLLKDKDPDIRKFSLDLIANIKKGFDASKLIPLLKDPNGNVRAATAHALGELGYRQAIPALIESLKDEEWVVFYVLQALAQLKAEEAADKIGELLLNTESILIKAEAIETLGKIGTEKVAEPLLKYFPVATKDEKQQIVKALIRIGIIPDGQDLKEEILSIFKEQEWDEKLIALKGIKLTNLIEAVPFIVEEAGGLDPSCFDYDEKIQALEETLLSINSEDELLSMIEKNKLKYRAKAFVIKVLGKLRSKKAVPILIKLLEDLKRDIRIASAKALGEIGSTEVIQPLIKKSIEDQDANVRKAAIEALGMIRASEAYEPLLNLLDREIYSDIIEVIVSALISINQEKFLENLKSYKREVKQALAGVIYSFDILNMLVQCEDKEVRKTALYALGRLATEQAISKILEFIKSDDKELKKVAILALGEANFCSDELFKCLKDEDAWIRYYTIKSISKACDPEVLLEKLTPLLDDPFPPVVIAAVEALSEISMPQVYDILASKKQHPDKEVREKIEEVLQKI