lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family. Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (By similarity). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion. Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (By similarity). May link TNFRSF1A with MAP kinase activation (By similarity). May be involved in the regulation of TNFA-induced apoptosis (By similarity).
Subcellular Localization:
Cell membrane. Cytoplasm. Cell projection, axon.
Sequence:
MVQKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHPEFPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRMPKEKAEGGAGPRGKEGAHAPCASEEAATESSESGSTLQPPSADSTPDVNQSPRGKRRAKAGNRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKPGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQEVQQALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQETPLLLGRFSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPSNYAFQRIHNNTFDPALIGDKPKWYAHQLQPIHYRVYDSNSQLAEALSVPPERDSESDPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASEVEIDELQPQKEGEEPGPDSENSQENLPLRSSSSTTASSSPSTIVHGAHSEPADSTEVGDKAATGISKPLPPVPPSICKSTVDRRQTETGEGSVCQRTYDHPYFEPQYGSPAEEDDDEQGESYTPRFSQHASGSRAQKLLRPNSLKLASDSDAESDSRASSPNSTVSNNSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKTTPFPSLKGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLSRAVQSEDDARQDVIQDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTENVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGRGPKELDTRSLKEENFVASVGPEVIKPVFDLGETEEKKSQISADSGVSLASASQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDLSSNAGDGPGGEGSAHLASSRATLSDSEIETNSATSTIFGKAHSLKPKEKPASSPVRSSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHVGLVYSQQINEVLDQLTNLNGRDLSIRSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVRSSEEDLRTPPRPVSS
The following text describes a protein:
Function:
Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal glycosyl residue.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MPSSPKSFNAWPSSSSSSTIYSRRSTVLIFCSLIGVAGFIFGFIAISKQGLGSNCKYAEPRSVSVVWDRSGSKASEDTDGVSDEGQKRHKVMGFVGIQTGFASTGRRRSLRQTWFPSDHEGLQKLEEATGLAFKFVIGRTSDQYKMAELKKEVAQYDDFLLLDIEEKYSKLPYKTIAFFKAAYALYDSEFYVKADDDIYLRPDRLSLLLAKERPHSQTYLGCMKKGPVFTDPKLKWMGGYEPLGYMLGKEYFLHAYGPIYALSADVVMSLVALRNNRQVGFVQNSVLFTAVAYITSGQTFRMFSNEDVTIGSWMLAMNVNHENNQHLCESECTPSSIAVWDIPKCSGLCNPEKKMLELHAKDACSKSPTLPSDEDD
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MSISHVLWSTALIALTSVKTADANIDTGANRREFGAMCNVLRWTSTTFTNKADDWDDDKIYNSIADINMTLAEKEWRAMFLQEGQAEKWQLKLPTKHAENAAFQKMWALWACAAQRVGSERGLTDKLKKLKANELTATDLSLRRQRVQQIADKAHGIYFELKKLNRKKLKATPATIKAKIYTAVLGKADAVLGTDPTDDDSITSGGTSAATRSNGCGNSNIANQPGKNLGTVALCVCAKGASGTAVDDACWSETAAEVAYPTAASQAKTKIHELIKMCGTAAHTKLTADAVEASIKGLTSIMHTSSSGTYIGEYLATGCNGEDNGVVCFKYGTLTTTTNSNLMTIPWLAELHQLKQDLTGDDNLERAGQPLVQQLTILEAEVKEITAGELLMRQDSLFVNQPTHPASPEKVATVGEVCSKHNGSNTTCPRDKRTYDEKENKCNPIKQVEGVTAEGTGEKTTTEKCRGKLEKDCKSPDCKWEETVCKDSSFLVNKKLALISTNFVDLMF
The following text describes a protein:
Function:
Involved in merozoite invasion of host erythrocytes.
Subcellular Localization:
Secreted. Cell surface. Host cytoplasm. Note=Secreted at the schizont stage into the host erythrocyte cytoplasm. Localizes to the cell surface of free merozoites to some extent.
Domain:
The PEXEL motif is involved in the protein translocation through the parasitophorous vacuole membrane and into the host erythrocyte cytoplasm.
Sequence:
MRLSKVSDIKSTGVSNYKNFNSKNSSKYSLMEVSKKNEKKNSLGAFHSKKILLIFGIIYVVLLNAYICGDKYEKAVDYGFRESRILAEGEDTCARKEKTTLRKSKQKTSTRTVATQTKKDEENKSVVTEEQKVESDSEKQKRTKKVVKKQINIGDTENQKEGKNVKKVIKKEKKKEESGKPEENKHANEASKKQEPKASKVSQKPSTSTRSNNEVKIRAASNQETLTSADPEGQIMREYAADPEYRKHLEIFYKILTNTDPNDEVERRNADNKEDLTSADPEGQIMREYASDPEYRKHLEIFYKILTNTDPNDDVERRNADNKEDLTSADPEGQIMREYAADPEYRKHLEVFHKILTNTDPNDEVERRNADNKEDLTSADPEGQIMREYAADPEYRKHLEVFHKILTNTDPNDEVERRNADNKELTSSDPEGQIMREYAADPEYRKHLEVFHKILTNTDPNDEVERRNADNKEDLTSADPEGQIMREYAADPEYRKHLEVFHKILTNTDPNDEVERRNADNKEDLTSADPEGQIMREYAADPEYRKHLEIFHKILTNTDPNDEVERRNADNKEDLTSADPEGQIMREYAADPEYRKHLEIFYKILTNTDPNDEVERRNADNKEELTSSDPEGQIMREYAADPEYRKHLEIFHKILTNTDPNDEVERRNADNKEDLTSADPEGQIMREYAADPEYRKHLEIFYKILTNTDPNDEVERRNADNKEDLTSADPEGQIMREYASDPEYRKHLEIFYKILTNTDPNDDVERRNADNKEDLTSADPEGQIMREYAADPEYRKHLEVFHKILTNTDPNDEVERQNADNNEA
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MSASTTTSPRESSSALMPPPSAPLPSSTMPTPLDEARLTDDDIDSLIASLSPTSELDHLRSIEKTIRETQMRRRKETEEHTAKIHALQSALSDLRKQSTRQAAEWRSLASHAETIEKLDNRNFDLAKKINEQESVLSNMQNEVMELKRTCDELEEVDIEDETEMDRDALCLRIFRSLGFLPSKSSTANNDDEWSSILVRSDTRNTAIQFDIQTSHLKQNEISPLILADQLWKAAE
The following text describes a protein:
Function:
Cleaves the N-terminal amino acid of tripeptides.
Subcellular Localization:
Cytoplasm.
Sequence:
MTYPNLLDRFLTYVKVNTRSDEHSTTTPSTQSQVDFATNVLIPEMKRVGLQNVYYLPNGFAIGTLPANDPSLTRKIGFISHMDTADFNAEGVNPQVIENYDGCVIELGNSGFKLDPADFKSLEKYPGQTLITTDGTTLLGADDKSGIAEIMTAIEYLTAHPEIKHCEIRVGFGPDEEIGVGANKFDAEDFDVDFAYTVDGGPLGELQYETFSAAGAELHFQGRNVHPGTAKGQMVNALQLAIDFHNQLPENDRPELTEGYQGFYHLMDVTGSVEEARASYIIRDFEKDAFEARKASMQSIADKMNEELGSNRVTLNLTDQYYNMKEVIEKDMTPITIAKAVMEDLGITPIIEPIRGGTDGSKISFMGIPTPNIFAGGENMHGRFEYVSLQTMERAVDTIIGIVRSL
The following text describes a protein:
Function:
May be involved in iron transport and iron homeostasis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEPGEEAGSAGHLVPLLDDHGGGGGGGLDASLLRRLYVGHFLARWGARMWEFSVGLYMIRIWPGSLLLAAVYGVVESSSVVVFGPMVGALVERLTYLQVLGLWLLVQSLSFITAGLSVTALLMYDKLKDTSFPVFLALVVVTNLSGALAALSTLAGTILIEREWVVVICSGHPPAVLTKTNSMIRRIDLSCKLLAPVLSGFIISFVSTQASAVALALWNVTSVWLQYWLFVSVYNGVPALSEDVQLRRRSTAALALAADEEVQRHGQDASDWKVGVTERLSILPCWESWAVYMRQEVMLPGVALAILYFTVLSFGTLMTATLDWKGIPAYVISLARGFSAVVGIAATLLYPVAHSWVSTLRTGLWSVWMQWCCLLLCVGSIWVSDGVASAWVLMAGVAASRLGLWMFDLAVMQLMQDGVPDSDRCVVGGVQNSLQSMFDLLTYIMGIIVSDPRDFSELIMLSFLLVTCAAFMYTLHVYRVRKHLLHLDKIFAKMGWCATFQ
The following text describes a protein:
Function:
Involved in chromosome condensation, pairing and segregation during meiosis. Responsible for cohesion between replicated sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MLRLESLIVTVWGPATLLARKAPLGQIWMAATLHAKINRKKLDKLDIIQICEEILNPSVPMALRLSGILMGGVVIVYERKVKLLFDDVNRFLVEINGAWRTKSVPDPTLLPKGKTHARKEAVTLPENEEADFGDFEQTRNVPKFGNYMDFQQTFISMRLDESHVNNNPEPEDLGQQFHQADAENITLFEYHGSFQTNNETYDRFERFDIEGDDETQMNSNPREGAEIPTTLIPSPPRHHDIPEGVNPTSPQRQEQQENRRDGFAEQMEEQNIPDKEEHDRPQPAKKRARKTATSAMDYEQTIIAGHVYQSWLQDTSDILCRGEKRKVRGTIRPDMESFKRANMPPTQLFEKDSSYPPQLYQLWSKNTQVLQTSSSESRHPDLRAEQSPGFVQERMHNHHQTDHHERSDTSSQNLDSPAEILRTVRTGKGASVESMMAGSRASPETINRQAADINVTPFYSGDDVRSMPSTPSARGAASINNIEISSKSRMPNRKRPNSSPRRGLEPVAEERPWEHREYEFEFSMLPEKRFTADKEILFETASTQTQKPVCNQSDEMITDSIKSHLKTHFETPGAPQVESLNKLAVGMDRNAAAKLFFQSCVLATRGVIKVNQAEPYGDILIARGPNM
The following text describes a protein:
Function:
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Subcellular Localization:
Membrane.
Sequence:
MAEAANPTFLLCLPLLFLLSGWFGAGRAGRDHHRGREIHLCQPSPSGNPLAVTVFGVFPPPQNSPVFWGFFSIDTHSFWYNFTIIRLPRHGQQWCEVQGQVDQKNFLSYDCGSDKVLPMGHLEEQLEATDAWGKQLEMLREVGQRLRLELADTELEDFTPSGPRTLQARMSCECETDGRIRGSWQFGFDGQKFLLFDSNNRKWTVVQAGARRMKEKWEDSGLTMFFQVFSMGDCKSWLRDFLMHRKKRLEPTEPLTVAPRTAQTKAMATNLSLWSLLIILCFILPGISGESFRVTGTVGKTVRGTRDRWVRWEEGKENSQSPTPPHGRDLLILT
The following text describes a protein:
Function:
SNARE required for targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.
Miscellaneous:
MISCELLANEOUS: Present with 4910 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Sequence:
MVVTFLQDLEVLQDALLNNLQKLSAISRRKESGESKHDNKDSFAAIANEHNDEEEEIEFEDLVNIIESKVSDFESVLKCSIVEMTYKYPELKLQWEKSPRYDQCDKLHIVKLDKQMNEDIYAQLVEELDFVLQFVDWFYCYRLKVKEILRQHHKRDLAWNDEKRDRAIKFHAVDYDKLHQGTSSSSSLTSTSMEKASTREKLLSKTKQLTNNLVRGNQILQSGILQSDLNLDELRAQTNSLTQIDDKYTQFETVFKKTADLVKVLENASHQEKRDVYLSLGFLLCCVSWVLWRRIFKLPVKLGLWLLFKFFKGILVTLGLVKSYAGSSSSLQAPSLVLNAPILATTTTSSATSVEPFASVSAVSSIQRAVDEAVDRIVSHDEL
The following text describes a protein:
Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex.
Subcellular Localization:
Cytoplasm.
Domain:
The BCB domain mediates the interaction with CUL3.
Sequence:
MARGPQTLVQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALAAEDELLQAVECAAFLQAPALARFLEHNLTSDNCALLCDAAAAFGLRDVFHSAALFICDGERELAAELALPEARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPADTTAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRNGPSDDFLHCAIDCLNLATGQWTALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEGGTWRLLREKAGFPRPGSLQTFLLRLPPGAPGPVTSTTAEL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
Sequence:
RNHGEAAGEASLTSELLAPPPPPPPPGSSKRRRSGKRARDGPLLFGTQLIRHEPPAEKQPPPTAVQVDKGKLYCSLCSCTLTPPIYQCAVGHLACCACRVKLPGRRCRTCSDRGAPSSSAYAHCPALDLFFTDLRVPCDFQEYGCERFVSYFLSASHRDTCEHAPCHCPEPGCPLLRSTRTLAAHLASDQSWPVEDVAYGAPIPLADDASLFPMAAGPLGDGAAVSVVLVRATAKPPPLPRFTCTFYANPPPGAAELAGSYFFATVPVRSSALADGAGVAPEKELYFAVPRETLHGSNRELFLSVRIDRSPAPEPAALEDKKMMITDHSNSLKADQ
The following text describes a protein:
Function:
Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
Subcellular Localization:
Cell inner membrane; Single-pass type II membrane protein.
Sequence:
MKSIRRGDGLNVVPFIDIMLVLLAIVLSISTFIAQGKIKVSLPNAKNAEKSQPNDQKVVVISVDEHDNIFVDDKPMNLEALSAVVKQTDPKTLIDLKSDKSSRFETFISIMDILKEHNHENFSISTQAQ
The following text describes a protein:
Function:
Salusin may be a endocrine and/or paracrine factor able to increase intracellular calcium concentrations and induce cell mitogenesis. Salusin may also be a potent hypotensive peptide (By similarity).
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: Salusin-beta peptide is derived from isoform 3.
Subcellular Localization:
Secreted.
Sequence:
MAVARHGYRPWGSILGLLGLALAAAAAWDVASLRCTFGSFCECDFWPDLPGLECDLAQHLAGQHLAKALVVKSLKAFVQDPAPSKPLVLSLHGWTGTGKSYVSSLLAQHLFRDGLRSPHVHHFSPIIHFPHPSRTEQYKKELKSWVQGNLTACGRSLFLFDEMDKLPPGLMEVLQPFLGPSWVVYGTNYRKAIFIFIRWLLAVWHHGGAPAGRCGALPPAPAASRAPLRTQ
The following text describes a protein:
Function:
Involved in the maintenance of the spindle integrity during the cytostatic factor (CSF) arrest of oocytes.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with the spindle at discrete sites during the second meiotic division.
Sequence:
MYPFIPPARLLPGSPAPFLPSGPSCPQPSGPYPGPAVRVPGPTRSYVSTNVPFPELPRPNSAPTDPVGPLGTQGSMSSGPWAPGMGGQHPNVPYLFPESSPTPPLPVSGAPPVAWVTVPPGAWEPPAQYPTPEASYPSPGLQPSPNNPYPLPPGPSAASPGPGSLHRMNEIPGGSPSDSSNPESTLESTGQKKHLKLDNKSIKRRRSKKKSKRVTWGDIKTLTHKAESLGKQQGHNTTDPKMMLLCLMTMLHVNSQHESEGSK
The following text describes a protein:
Function:
Translation factor specific for subunit 6 of the mitochondrial ATPase. Required for assembly of the CF(0) component of the ATPase.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MLKCICRVYSQPLAQMVTSPLFKHMGSAGTYTILPITNLRHLSTKNCPLKIKSNRSEPLQFGDFERQVPCSRKSGSSKNVQKRLYELRQLKTVLSETFGVTEYASFFESLRNALHINNCSENEKKKLLYDIILHQHELYPEVARKIGFYLPGEVHRWFWYHIPKSESFNHYLFLLKSDVLLFTSNYCTRFTNRLIKGTEMERQLATFQIFLHDETNIKFIMEKVLKLHTFDSLIALVNGLVKAKNFRFIKVFIQALLQKLEQHCYSGKDGAKQKNLRYVKFNNTLLYYLLKSGNVELFIKTFQEELKFIVSSGLLNHIDGNEHILNFPIHHYLNLLRISNRQEELFNVISCLQSSPLMKYKLFKEFLMGELIASFQAFRDPKLVCKYLLSSYSSKASANILNALGIWGWLYHSKSTTLTAPTLARELKNKNNILPNTMRIGSPVTVPILTELYRSLLSSSSVSLESGQFKNCLLDLYYKYKSFLSEEAHKYRYWRNDTGILNVFLNYIRFQAREPRLAYNVLLDFYSQPFAKKVVLTTTLCPFSIVAYKNHTLTQAELSELLQVMHKNGVPLTFKFCSAMVMHYVKMRDEKGARSWYNKILFGGFEIRHMALIQIIKDQGWPFPKNFDETLLTELVENNNIKEPTDSTLFTDEDMFEEDGKPRFNDDDVNKCTNIIRETLKSLN
The following text describes a protein:
Function:
The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.
Miscellaneous:
MISCELLANEOUS: Present with 1400 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MAKTLKDLDGWQVIITDDQGRVIDDNNRRRSRKRGGENVFLKRISDGLSFGKGESVIFNDNVTETYSVYLIHEIRLNTLNNVVEIWVFSYLRWFELKPKLYYEQFRPDLIKEDHPLEFYKDKFFNEVNKSELYLTAELSEIWLKDFIAVGQILPESQWNDSSIDKIEDRDFLVRYACEPTAEKFVPIDIFQIIRRVKEMEPKQSDEYLKRVSVPVSGQKTNRQVMHKMGVERSSKRLAKKPSMKKIKIEPSADDDVNNGNIPSQRGTSTTHGSISPQEESVSPNISSASPSALTSPTDSSKILQKRSISKELIVSEEIPINSSEQESDYEPNNETSVLSSKPGSKPEKTSTELVDGRENFVYANNPEVSDDGGLEEETDEVSSESSDEAIIPVNKRRGAHGSELSSKIRKIHIQETQEFSKNYTTETDNEMNGNGKPGIPRGNTKIHSMNENPTPEKGNAKMIDFATLSKLKKKYQIILDRFAPDNQVTDSSQLNKLTDEQSSLDVAGLEDKFRKACSSSGRETILSNFNADINLEESIRESLQKRELLKSQVEDFTRIFLPIYDSLMSSQNKLFYITNADDSTKFQLVNDVMDELITSSARKELPIFDYIHIDALELAGMDALYEKIWFAISKENLCGDISLEALNFYITNVPKAKKRKTLILIQNPENLLSEKILQYFEKWISSKNSKLSIICVGGHNVTIREQINIMPSLKAHFTEIKLNKVDKNELQQMIITRLKSLLKPFHVKVNDKKEMTIYNNIREGQNQKIPDNVIVINHKINNKITQLIAKNVANVSGSTEKAFKICEAAVEISKKDFVRKGGLQKGKLVVSQEMVPRYFSEAINGFKDETISKKIIGMSLLMRTFLYTLAQETEGTNRHTLALETVLIKMVKMLRDNPGYKASKEIKKVICGAWEPAITIEKLKQFSWISVVNDLVGEKLVVVVLEEPSASIMVELKLPLEINYAFSMDEEFKNMDCI
The following text describes a protein:
Function:
Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines. Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation. Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation. In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism. Also plays a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits.
Subcellular Localization:
Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MTSHRASTSSTLSSGSATPRGLGHAPSWTDDLPVCPLSGVGSSTNQTYRLDGLRQEEHPFEDRCFHFRHESDVYLYGVFDGHDGNRASDFATQRMPAELLLGQLDKIQTDRDVKMALHQAFLAVDKAFFEAIDDYLCEKTTLQLELPEGMSDYEVYQQYPQLVDKLHALDEKITGGTTAVVALILNNKLYVANAGDSRAVLCKTKPDSSLEVVQLSNDHVIDNPDETLRLSQLGLNMELIRSQGSRLGNQDCTRTLGNYHLKGGYKDFDILSVATAEPVIAEPDVVGGITVDESCSFLMLFSDGLYKSLEKCTGTDSVNRDLAYMVSEELGNQSTLNSVAQAVVDRVVRLHHDTFMRGGDHARLCAKRPDIMLIVRNFNHPFPNSLTSPTQGGVYNPVSVPYRPHKNEGPPPKLIMPPKQPVPTNLHETSPTTTVVAPATNQSPVVAQQSPSATMSEVADTNVTQTTGTTSSDTERSGPELRLFRRRQRSYQPLTLDDDGLVEPYVDFSDFHQRWNEFMKTQKEHISSLQEEKEPSLKEEPDKELEEEEAQR
The following text describes a protein:
Function:
Dioxygenase that catalyzes DNA modification by mediating the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-glyceryl-methylcytosine (5gmC). Catalyzes the conjugation of a glyceryl moiety from L-ascorbate (vitamin C) to the methyl group of 5mC through a carbon-carbon bond. 5gmC DNA modification may be required during photosynthesis as an epigenetic mark that couteracts DNA methylation.
Subcellular Localization:
Nucleus.
Sequence:
MSVALASEYQLVQNAQLPQRWSQSARKSLAILEATARKEATAQMEAAGGSFCGQFPVDPAFKVLSLEYSAPNPDIARAIRRVDSVPNPPLPSHVVAIQSTAVDADLSLAMGVSLTPGRHTSYLVDARALQQSNSAAVAARKADGDKWGPACDEMFRGCRCVTGQEVVFYTAVKEPAGEVEGGEGSLFKPSFDGPAFRPSWGELSGKATGVVACVLQVPIGKETDIICAEYDNLVSKGQFATVDRFGGDHTVNMTGNALIQNDGKAISKGYAVAHRARVTSNVYGKANDVSLQRLAETVWSVVEKRLSFMPAYRDLVITEQGKPFMLGATATNIISLTENQGVMLHLDTDDGVWTIILWFHRHSGIIAGGEFVLPSLGISFQPLDFTIVVFAANTIVHGTRPLQTTGKIIRWGSSHFLRFKDVNALAQLGAAYGVDELDAKQRDQLEEVDAANSKDGVGAARRVASCMAAERKAAIEAQKAACVRGVVMNPCTGRMPSLLFWQVWRKPPALAVRANAVAGKKRAAADVDFCGA
The following text describes a protein:
Function:
Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.
Sequence:
MNKPEKKPGSRAAQAGARPSRPAAPRKQPGRESEHQPSTYRLFYALRVPADITAPLAEAQAKLRGNWRAVRPDQMHVTLSYLPAVPPERVEDLKRLGTRLTQDLPPLHVNLRGTGYFPNEGSPRVWFVKTEAEGLTELAENLRAGIRELGIGTDDLAFKAHITLARKKGPAPRLPPLIFDQSWTAPGLTLYRSILRKTGPIYEVQSTFRFRGSASQTSAESAPTAAPSAPQEHP
The following text describes a protein:
Function:
Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
Sequence:
MKAIGSKPVRALPVGARCICADNTGAKEVEIIAVRNYKGVARRLPTARVGDMVIVTVKKGTPEMRKQVLPAVVIRQRKEIRRPDGTRVKFADNAVVIVTPDGNPKGSDIKGPVAKEAAERWPGIARIAKIII
The following text describes a protein:
Function:
Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine. ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy. In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components. ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.
Subcellular Localization:
Cytoplasm. Nucleus. Preautophagosomal structure.
Sequence:
MNDFERFGRNVVRTFYDPPPCNESNEPIWLLGQRYDSRPPLPKPAPSDSSTTATATAQAERNEDESWIRTSIDDKERKEAPNGEDPTQYGNWPSAFLDDFESRVWMTYRSGFSPIQKSQDPKATSAMSFRVRMQNLASPGFTSDAGFGCMIRSGQCILANALQILRLGRDWRWQENHADKDHAEILSLFADDPQAPFSIHRFVEHGAAVCGKYPGEWFGPSAAARCIQDLANKHREAGLKVYVSGDGADVYEDKLKQVAVDEDGLWQPTLILVGTRLGIDKITPVYWEALKASLQIPQSIGIAGGRPSASHYFVGVQGNNFYYLDPHSTRPLLPFHPPSLAAATSDTPNLTASTTSVSSTTSSTTIVPPADSIPAPSDPRQSLYPPSDLSTCHTRRIRRLQIREMDPSMLLAFLVTSEADYQDWKEGVQGVQGKSVVHVQDKEPPPRGQEREGAIDEVESWDEDGLQ
The following text describes a protein:
Function:
Mannosyltransferase involved in the biosynthesis of the repeat unit of the lipopolysaccharide (LPS) O-antigen region. Catalyzes the addition of a mannose to the rhamnosyl-galactosyl-undecaprenyl diphosphate intermediate.
Sequence:
MIVNLSRLGKSGTGMWQYSIKFLTALREIADVDAIICSKVHADYFEKLGYAVVTVPNIVSNTSKTSRLRPLVWYVYSYWLALRVLIKFGNKKLVCTTHHTIPLLRNQTITVHDIRPFYYPDSFIQKVYFRFLLKMSVKRCKHVLTVSYTVKDSIAKTYNVDSEKISVIYNSVNKSDFIQKKEKENYFLAVGASWPHKNIHSFIKNKKVWSDSYNLIIVCGRTDYAMSLQQMVVDLELKDKVTFLHEVSFNELKILYSKAYALVYPSIDEGFGIPPIEAMASNTPVIVSDIPVFHEVLTNGALYVNPDDEKSWQSAIKNIEQLPDAISRFNNYVARYDFDNMKQMVGNWLAESK
The following text describes a protein:
Function:
Binds and inhibits voltage-sensitive potassium channels. Inhibits the vertebrate potassium channel Kv1.1/KCNA1 with low affinity.
Subcellular Localization:
Secreted.
Domain:
Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
Sequence:
DEEPKETCSDDMCVIYCKGEEFSTGACDGPQKCKCS
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Subcellular Localization:
Cytoplasm.
Sequence:
MANQLKVGIIGAGAMGLLYAANFANISELTLFTRRKEQSDLLNQKGLSLKDNSELKNIHIQATVITDAEKLSEQELLIIAVKQYSLKTILPLLRSIPERVPLLFIQNGAAHLDSMPLLGNKRTILLGISEHGAGREDDTTVIWRGHGRTKYSIYQGELNEAVIKILDSNPDFPVEKHASYLDIINEKLFINAVINPLTAVLQVQNGKLLENKEWHELLKTIVKEIQTVLPVENALEKVEVICQVTATNFSSMALDRMNNRMTEIDGIVLPILEKGESLPTLHALYHLIKGLEGESDV
The following text describes a protein:
Function:
Provides the (R)-glutamate required for cell wall biosynthesis.
Sequence:
MKQAIGFIDSGVGGLTVVREVLKQLPHEQVYYLGDTARCPYGPRDKEEVAKFTWEMTNFLVDRGIKMLVIACNTATAAALYDIREKLDIPVIGVIQPGSRAALKATRNNKIGVLGTLGTVESMAYPTALKGLNRRVEVDSLACPKFVSVVESGEYKSAIAKKVVAESLLPLKSTKIDTVILGCTHYPLLKPIIENFMGDGVAVINSGEETASEVSALLDYHNLLDATDEEIEHRFFTTGSTQIFKDIAKDWLNMPDMTVEHIKLGK
The following text describes a protein:
Function:
Required for normal Golgi function.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MESSVEKANPLAKKLAKIKDNQFENDKDTLEALKELSTFFSENSIRTRRNLRGEIEGRSLAINQDIFKAFHQVKEGKQIISRFFNDKTNRASNFLDSALNDVHSQVLFMDQSCKGMSTKLAAVKTRTHQLMSQMTSFQTASNQLSMEQMVASKMIETFQLTPAEVTELQSFDRSVNPEFFTALRKSKHIHQQCKQLLQSGHQTTAFEIMEQMASYQETALERLYRWTQNQCRNVDSPDSNILLTQAISCLQDRPILLKYVVDEYCTVRRGLVARSFLDALTVGGPYGTPRPIELHAHDPARYVGDMLAWLHQMTPTEKENAQALLKGCDKSDIGELVKGALSNITEGVCRPLRLRLEQVISPDIGPAVLHTLSGLIRFYLNTIGEVVPNSALIETLNDIFDQCHHTFLTSLESHVHRLLERIQPPSQDLSPSLGVNQLLNLLRDVLSGGHIVDAQASDVAEVVSRVLDPLMQFIENTAGRLPRVDQAAYTLNCVYQIHSSLSLYEHVEERLENLQGLMENQLTLLSTEQATSLIHSLGLGPVCALLQNQNDGELLSNIPGMDSSSLQSFLIKLDALLGAPDALQLAQWKLLISGSHRKIIQRRALDTVLSIYEQLYDAVHNPANCYENPSSIMPRTPQQVRNLLA
The following text describes a protein:
Function:
Probable ppGpp (guanosine 3'-diphosphate 5'-diphosphate) synthetase that may be involved in a rapid plant ppGpp-mediated response to pathogens and other stresses.
Sequence:
MTPSVSCPVKCRPHPCLAPQPPAPSPELLAARGAPIAGELRACRSPPYLPLSRSADSLELRAACRGAPPASRARAAVALGGDGPSAALIAGAQSRHAIFRDELVRRAFTAAEAAHRGQVRASGDPYLQHCVETAALLAELGAGPAVVAAGLLHDTVDDAGLGYGFISEHFGAGVADLVKGVSNLSHLSKLARRNDTASRIDEADRLRIVFLAMEDARAVLIKLADRLHNMRTLDSLSKTKQQSVAKETLEIFAPLANQLGILNWKEQLENLCFKYLYPENFDELSTKLIEIYNIDMIAAATRRLEQALQVRGLSYYAIYGRHKSMYSIYRKMARKKLVMDKIYDIHGVRVILENKADCFATLEIIHHLWPRIPGKFKDYINSPKPNRYQSLHTVVLTEQTLPLEIQIRTRDMHLQAEFGIAAHWRYKEGYPSSLACDASSKETHTIPSHSDACLLSYSKQCDHKGPVLVILLENEKMSVQEIPQNWTILDLLKRSSNYGMPLRLRLNCHAVHNWNQELKMGDVLELIPSTPCKSRGHTRELHQKFDHRLAVSQS
The following text describes a protein:
Function:
Dynein-attachment factor required for cilia motility.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm.
Sequence:
MAHLKEDRIDFTKLEKELTAAIDADASYWRVNGAKIRAMEQRVETYDQFRDLVAAAHIKPLEKKDKISQSKRHQPWNPFSSSNSTTSSSTSPQETGDQVQSSITKVKIPKNGHEFTKEWRNRKKTSGSCYSYMLDLGGDTLAKIFRAEISFGLLGEIITTLNDHAEEKHCGKIADILVCLTRAGRFGLSLDFLNKSEKQALSELMGKLEQWRQAVDRTEEDSVAAEENEEGTKTEDCKKERLEGDKREEGEQEEGTEGIAQESCAQFFLEDIVKLKELYKLSEK