lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Converts protoheme IX and farnesyl diphosphate to heme O.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MYKTPCRRLSGFVGVHVKQKLLQNAPQSNQTFSCLIQLHRRDPSTWLTYQHLNFLKRLYVTKKGSELHQRAIPKQSHIMNTVDEKDDSLETEVERISAINPLMPDSVSQPDFVAAKLQPKLSTPQPAMEKKTLPERTVSQAEASSAEPPHIYVETEEVRQARLDRQWKQLKLDLSELPDIYSRLSKIKLTALVVITAAAGFSMAPVPFDPINFVVSSLGTGLASCAANTINQYFEVPFDSNMNRTKNRPLVRGQISPLHAVSFALACGVPGVALLTLAVNPLTGFLGALNIFLYTCCYTPLKRLSITNTWIGALVGAIPPVMGWTAATGCVDPGALLLGGFLYSWQFPHFNALSWNLREDYSRGGYRMMSVTHPSMCKRVALRHSLALIGLSTMAPVLDVTTWTFPVISLPINLYISYLAFRFYQKGDRNSARKLFFCSLWHLPMLLLLALTCKKYNRGGEDSGPAPLTVPAN
The following text describes a protein:
Function:
Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type III membrane protein. Cell membrane; Single-pass type III membrane protein. Cell projection, growth cone.
Sequence:
MQPTATMATAAATTATVALTTSWDNATSRPTAEPDPILDNYVLLVVVMSLFVGGTLVVLSGVLLLCKRCWEVHQRFNRAMEEAEKTTTTYLDNGTHPIQDPDCRGEDPEGQDTETERFLATSSTGRRVSFNEAALFEQSRKAQDKGRRYTLTEGDFHHLKNARLTHLHLPPLKIATIHECDSGEASAAATPHPATTSKDSLAIFQPPGKTLTGHSVGPSSALPGGPYNSVDFSEISPSTSSDSGEGISLDAGTRGAKAAGPETVPGEMGTGSSGSGTVLQFFTRLRRHASLDGASPYFKVKKWKLEPSQRASSLDTRGSPKRHHFQRQRAASESMEQEGDVPHADFIQYIASAGDSVAFPPPRPFLASPTSPPPTLGRLEAAEAAGGASPETPPEHGISLGPEHAQQQDPQQEQDAEHAQCSYRDLWSLRASLELHAATASDHSSSGNDRDSVRSGDSSGSGSGGGGAAPAFPPPPESPPALRPKDGEARRLLQMDSGYASIEGRGAGDEVSELPAPARSPPRSPRAWPRRPRRDYSIDEKTDALFHEFLRHDPHFDDAPRHRTRAHPHTHARKQWQQRGRQHSDPGGARAATPPGVARPTRAPLRRGDSVDCPPEGRALPITGDDPSIPVIEEEPGGGGGGCPGSGLCVEPAGALLDKLAASLDERLFSPRLAEPVASSQVLIVAAAAPTSPDHSPA
The following text describes a protein:
Function:
Functions at the internalization step of the clathrin-mediated endocytosis (CME) as an early-acting scaffold protein. Requires clathrin adapter proteins, ENT1/2 and YAP1801/2, for normal spatiotemporal dynamics and viability. Binds to biological membranes in a ubiquitin-dependent manner.
Miscellaneous:
MISCELLANEOUS: Present with 1380 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Note=Localized to actin cortical patches concentrated in the developing bud tip in cells with small buds and at the mother-daughter neck in cells undergoing cytokinesis. Localization can be maintained in the absence of polymerized actin filaments.
Sequence:
MASITFRTPLSSQEQAFYNQKFHQLDTEDLGVVTGEAVRPLFASSGLPGQLLSQVWATVDIDNKGFLNLNEFSAALRMIAQLQNAPNQPISAALYESTPTQLASFSINQNPAPMQSGSATGNTNNTDIPALSSNDIAKFSQLFDRTAKGAQTVAGDKAKDIFLKARLPNQTLGEIWALCDRDASGVLDKSEFIMAMYLIQLCMSHHPSMNTPPAVLPTQLWDSIRLEPVVVNQPNRTTPLSANSTGVSSLTRHSTISRLSTGAFSNAASDWSLSFEKKQQFDAIFDSLDKQHAGSLSSAVLVPFFLSSRLNQETLATIWDLADIHNNAEFTKLEFAIAMFLIQKKNAGVELPDVIPNELLQSPALGLYPPNPLPQQQSAPQIAIPSRASKPSLQDMPHQVSAPAVNTQPTVPQVLPQNSNNGSLNDLLALNPSFSSPSPTKAQTVVQNNTNNSFSYDNNNGQATLQQQQPQQPPPLTHSSSGLKKFTPTSNFGQSIIKEEPEEQEQLRESSDTFSAQPPPVPKHASSPVKRTASTTLPQVPNFSVFSMPAGAATSAATGAAVGAAVGAAALGASAFSRSSNNAFKNQDLFADGEASAQLSNATTEMANLSNQVNSLSKQASITNDKKSRATQELKRVTEMKNSIQIKLNNLRSTHDQNVKQTEQLEAQVLQVNKENETLAQQLAVSEANYHAAESKLNELTTDLQESQTKNAELKEQITNLNSMTASLQSQLNEKQQQVKQERSMVDVNSKQLELNQVTVANLQKEIDGLGEKISVYLTKQKELNDYQKTVEEQHAQLQAKYQDLSNKDTDLTDREKQLEERNRQIEEQENLYHQHVSKLQEMFDDLSQRKASFEKADQELKERNIEYANNVRELSERQMNLAMGQLPEDAKDIIAKSASNTDTTTKEATSRGNVHEDTVSKFVETTVENSNLNVNRVKDDEEKTERTESDVFDRDVPTLGSQSDSENANTNNGTQSGNETANPNLTETLSDRFDGDLNEYGIPRSQSLTSSVANNAPQSVRDDVELPETLEERDTINNTANRDNTGNLSHIPGEWEATPATASTDVLSNETTEVIEDGSTTKRANSNEDGESVSSIQESPKISAQPKAKTINEEFPPIQELHIDESDSSSSDDDEFEDTREIPSATVKTLQTPYNAQPTSSLEIHTEQVIKYPAPGTSPSHNEGNSKKASTNSILPVKDEFDDEFAGLEQAAVEEDNGADSESEFENVANAGSMEQFETIDHKDLDDELQMNAFTGTLTSSSNPTIPKPQVQQQSTSDPAQVSNDEWDEIFAGFGNSKAEPTKVATPSIPQQPIPLKNDPIVDASLSKGPIVNRGVATTPKSLAVEELSGMGFTEEEAHNALEKCNWDLEAATNFLLDSA
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAQSLSSQLGQLQHQQKQYASLLYTQQVSAKTDLDTIYYQGCKGMNKLTQIDTRFSRFQESLFNVQNKGITRQLQTKQQNADLDKEIRQCLLLMSQYWTFEGTHSAMEYLLRNYRVHEYLVDEVIIYFLVYHNTKLYVRLLQNLVDQQRNSMWAFLYEPISRGQTIPRDLLIRQMQLDYRILKKIIDYQCLLLQKVEVQEEIVFTVQDYLYTEQEIQNIKLRQPNQLAFLYSILQDLKVTTGYMDQLRGSFGKLLALCIENCTDENKSFAYLIFNLQLFDPTKILLTENQIENTAQWIYSQVQHNDNLLDLAILFYQFGIKTTYETSLILLSKDLSKFFNNGLLLIEIIKQLKDIQIPEKQLHQLIFYLKHQLSKNDTHFLDSIVSIMHDQIITVVRPYLQDTQYKHLFPKSNQIHLTFNNSEQVIKQLNQKDADLSIGTLVNLIEDSYNYFIKSKKIQFIKILNQSLQIAETQFPQTVMFNTNKLYALINNISDQTDNRDLIQSLLPIFTYTHTKQVDANYYESLLLLNVHFQIETINEFSKSNKILKQVSNKEQLIKLIQQQDEKLIESLLYNNQVQKLLIYKQLQIQLSYILQDEQKLQKFINEYTEDDQFIAKTMQSLSIIQLLNLENSLCIKFIKSIEIDPQLFFNTELNHLGSLKILLHKSSRNVNFAFKLFLIYDDLTVEQQELYLQIAAELKESFKSDLKIQKIQFSQSLLQQTIGSLIKNRKEANFTKTLGNLKDQNALLDLQTLYLENFNDLRYRQLRSICSTFTKTKQSIKQDKVISLIKFIETNFKYDLLQSYLNILKYYGSIKDQNEEIDFSFLKKTLFKLPKDYCAVINEYISQANLFSAEVRTQMIIYVFSHNLKNKQIVVQDDLDFDLIISLLETPNLDILTHLVDLLRANIQHITVESIRKCFKLNINQPAQIILISQILYDYLDHHQINLLEECSSLQKKVLDQNLDLSLQINYTATTSCIRLIAKHTQINKCKSAFKSLTYPDIATYGQHNSLLFYRIIIEQFQNHNIKYFNSCIFAYFISQLIQITSTMDVNQEILQNFGLFSLEQWWVIMYILSTYYFTSEYIKLFKEQVNKFSPQIKLHISTALAESLFYRTQRHQKLLQIKLNQKLTQLQTPNLESCIKKVGFSLRGQIKPIKIKLSLLRILELVEDLQAQLSNYLIQSDLNAKQADQLKSLIVHISKFSNVFAHSKLKALSERVRTSLIHSMKIETLVPLIKNCISIKSVSHILLQAFNDILRLDLIKIQKQQIQLIRDLISQIIIEISLPTPNLSTEMLLLLNYLYSIQFIQKQLQQQGQEIMSVLIKLLDSQNEQDQSLILNLYSLLSQIDSYPYLNDLNQVFNMLITLLCKEENIKKLDNNQFTYNTEQIIHKVSNKLILLNTSYALIKSFKGLISKQHLTDISVLYLIESDKQGFQCILDNIENRVHLDVYINSILNQARKLKPFVVFNCVEYIAQLISKCESELVSEQLMQLNKEVQSIFDYSREQYIDSELKNGIFEADKLEYQINQVYIEIVMKINDVSFKKLYSNLIAWSRKQIQEVGYNFNKYRRIQFFRLSTQTSDKLGKYFTKYYSYIWDAIVNELQTFHNIFYETPKQTKLQKRTNDECDMYYRLELLLNRHILQSISSLCQNDCEQFVDTEKFEKLSDPLALTLDCPKVQQYESILQYIDEWITPTILALFQLINDDYKWKDLHLKILQVISRHSNKKNETSSFIIIAIIKLIHRLIDQLDERYLVLMNDLIPYLHQLTSTNLNSEELEKRVKQLIVRLSQLSGEDIVTALK
The following text describes a protein:
Function:
During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes.
Sequence:
MQVNISGHQLDVTDALRDYVGEKLSRLERHFDKITNVQVIMEVEKLKQKIEATLRIAGGEIVANAEHEDMYAAIDLLIDKLDRQLIKHKEKYLERQQGVGAR
The following text describes a protein:
Function:
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Miscellaneous:
MISCELLANEOUS: Present with 12400 molecules/cell in log phase SD medium.
Sequence:
MFNNHEIDTILSTLRMEADPSLHPLFEQFEKFYEEKLWFQLSESLTKFFDDAKSTPLRLRLYDNFVSKFYDKINQLSVVKYLLASLKDSKDFDESLKYLDDLKAQFQELDSKKQRNNGSKDHGDGILLIDSEIARTYLLKNDLVKARDLLDDLEKTLDKKDSIPLRITNSFYSTNSQYFKFKNDFNSFYYTSLLYLSTLEPSTSITLAERQQLAYDLSISALLGDKIYNFGELLHHPIMETIVNDSNYDWLFQLLNALTVGDFDKFDSLIKVQISKIPILAQHESFLRQKICLMTLIETVFVKNIRMLSFEDISKATHLPKDNVEHLVMRAISLGLLKGSIDQVNELVTISWVQPRIISGDQITKMKDRLVEWNDQVEKLGKKMEARGQSIWV
The following text describes a protein:
Function:
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLHPQQMQEQQQQQQEAQAASIIPEHYEMEYIQRNNKTVSFCQIPISILGGAIAGVIGFSGVYGFLFYFFIYITFCSLFTLKENKNLHLYFPNPRSIWFDSIGAGLMPYILFWTFLYNIIHIY
The following text describes a protein:
Function:
Plays an essential role for mitochondrial structure and function, as well as thermogenesis of brown adipocytes. In brown adipose tissue also localizes in the nucleus where it interacts with the chromatin remodeler SMARCA4 to regulate thermogenic genes expression, such as UCP1. May regulate phagocytosis and inflammatory responses to lipopolysaccharide in macrophages (By similarity). Involved in tumorigenesis and may function as a negative regulator of the p53/TP53.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein. Nucleus. Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MALSRVCWARAALWGSTVAPGPFVTRRLQLGRSGPAWRAPRSSKLHLSPKADVKNLISYVVTKTRAINGSYHRFLGRHFPRFYALYTTFMKGIQMLWADGKKARRIKADMWKQNLKFHQLSYREMEHLRQFRRDITKCLFVGLISIPPFANYLVFLLMYLFPRQLLVKHFWTPKQQIDFLDVYHGLRRRSHSEVITHLRRASTFVSHEKLRRQLTDLCTKVQSGTHPAAQDVLALRDCFSTYPLGFSQLQASQMRALSQAMLLTPYLPPPLLRQRLKSHTTVIHQLDRALAKLGIGQLTAQEVKSACYLRGLNSTHIADDRCRAWLGEWLHISCSLKEPELSLLLHNVVLLSTNYLETRR
The following text describes a protein:
Function:
Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density. In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression. Seems to negatively regulate SRC function in epithelial cells.
Subcellular Localization:
Cell projection, dendrite. Membrane.
Sequence:
MQQVLENLTELPSSTGAEEIDLIFLKGIMENPIVKSLAKAHERLEDSKLEAVSDNNLELVNEILEDITPLISVDENVAELVGILKEPHFQSLLEAHDIVASKCYESPPSSPEMNIPSLNNQLLPVDAIRILGIHKRAGEPLGVTFRVENNDLVIARILHGGMIDRQGLLHVGDIIKEVNGHEVGNNPKELQELLKNISGSVTLKILPSYRDTIAPQQSYVNMERHPAHVRQVFVKCHFDYNPFNDNLIPCKEAGLKFSKGEILQIVNREDPNWWQASHVKEGGSAGLIPSQFLEEKRKAFVRRDWDNSGPFCGTISNKKKKKMMYLTTRNAEFDRHEIQIYEEVAKMPPFQRKTLVLIGAQGVGRRSLKNRFIVLNPARFGTTVPFTSRKPREDEKDGQAYKFVSRSEMEADIKAGKYLEHGEYEGNLYGTKIGSILDVVQTGRTCILDVNPQALKVLRTSEFMPYVVFIAAPELETLRAMHKAVVDAGITTKLLTDSDLKKTVDESARIQRAYNHYFDLIIVNDNLDKAFENLQTAIEKLRTEPQWVPISWVY
The following text describes a protein:
Function:
Core component of the smc5-smc6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the smc1-smc3 cohesin complex to double-strand breaks (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with chromatin.
Domain:
The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of smc5, forming a V-shaped heterodimer.
Sequence:
MSKRKLGHDGNSHELDEEEEEEEEDDDDELIHSTQDQDRPHKQQRVENGKQMTPTKQHQQQQQQQPISNGRLKKLKAQSSDEESGSSEDDDEDVEDVDSSGSDSGSSDDDDDDDDDDDDDDGNSEDEREAVRREQQLKSGVTEPEAGIIESITLENFMCHRHFKLDFCSNVNFIAGENGSGKSAVLIALIVCLGAKAGFTNRGSKLSDLVKAETNTAVITVKLRNQGQEAFKPEKYGKSVIIERRISRTGSSGYKVKDYNGKTVSDKFNDVSLILEQFNIQIDNPMSILTQDTSRQFLNSAGPQDKYKSFLMATQLDKMTKDYTTIREHIDKIKDMLSQKVVVIQELEKKVREYNKEYKDLQQMVGLERKISEFKNQLAWSFVVESEREAKRKEKQVAEAEERSFDNDIRKVDETIETYNKSIEDIKKDIKEFTDQIKIQEQKKETNNREILTIEREEAKIQTQIEANNKKRQQRKQRRHLQLQSINEIKERNAQLANNQSKLDEIKKKGQQKLQLEARKEELIKEKEDLMRDRENLKRDHQNQRTITQQMNREYEGLRVQLNNLRSTQKGENQAYGKGMTDFLHKIEASRRNFSKLPIGPIGLSLKIKNESWAFAIESAISKATLRNFLVFSIPDGITLQKLGHQFGIKVDYTKIPETTEVYKTVEHDELDPSLATVLRVLDSPSHFIINFLIDTKKVEQIGLGNDRKEIDSVLYTDRCPRGLSQFFDPQGNNYSKTKSGNPFYQAAKNSGEATMLRVNSDAAIQRTQRDMESKLPALNQQKKIEQELSSDVQAIEHKISQNDQDQNQCSRKILQITNEIKSIEDTLVQQTDDYSELEIGLASLDEEIKSMDEEINIQKAQRTEVAAQKGPFAENNRALDDQIDVLSNQLGNIENNLRKFNEGLRKLNNNKQALLQQQGRSAQERDQFKAEYQRILEIVKEKTDKATQICERIEIPTNETNTTLTNKIIQYTKQLEKESRGKRSRTEALKLFQDANNSLKEISEQRDNIEELATILERNLNERYKKWQRFRLSISRRSDQYFNIFLSKKGYTGSLTFDHQNGKLDINVELQKALPSNQNGTAKGDTKGLSGGERSFSTVSLLLAFWENMECPFRAMDEFDVFMDEVNRSISINLLMSKAEENRSKQYIFVTPLALNHIKTSEYVKVFRVRAPVRTGGDVTVETD
The following text describes a protein:
Function:
Involved in microtubule organization by the microtubule organizing center, the spindle pole body (SPB). Probably part of the microtubule attachment site at the SPB.
Miscellaneous:
MISCELLANEOUS: Present with 56 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Sequence:
MELEPTLFGIIEALAPQLLSQSHLQTFVSDVVNLLRSSTKSATQLGPLIDFYKLQSLDSPETTIMWHKIEKFLDALFGIQNTDDMVKYLSVFQSLLPSNYRAKIVQKSSGLNMENLANHEHLLSPVRAPSIYTEASFENMDRFSERRSMVSSPNRYVPSSTYSSVTLRQLSNPYYVNTIPEEDILKYVSYTLLATTSALFPFDHEQIQIPSKIPNFESGLLHLIFEAGLLYQSLGYKVEKFRMLNISPMKKALIIEISEELQNYTAFVNNLVSSGTVVSLKSLYREIYENIIRLRIYCRFTEHLEELSGDTFLIELNIFKSHGDLTIRKIATNLFNSMISLYYEYLMNWLTKGLLRATYGEFFIAENTDTNGTDDDFIYHIPIEFNQERVPAFIPKELAYKIFMIGKSYIFLEKYCKEVQWTNEFSKKYHVLYQSNSYRGISTNFFEIINDQYSEIVNHTNQILNQKFHYRDVVFALKNILLMGKSDFMDALIEKANDILATPSDSLPNYKLTRVLQEAVQLSSLRHLMNSPRNSSVINGLDARVLDLGHGSVGWDVFTLDYILYPPLSLVLNVNRPFGRKEYLRIFNFLWRFKKNNYFYQKEMLKSNDIIRSFKKIRGYNPLIRDIINKLSRISILRTQFQQFNSKMESYYLNCIIEENFKEMTRKLQRTENKSQNQFDLIRLNNGTIELNGILTPKAEVLTKSSSSKPQKHAIEKTLNIDELESVHNTFLTNILSHKLFATNTSEISVGDYSGQPYPTSLVLLLNSVYEFVKVYCNLNDIGYEIFIKMNLNDHEASNGLLGKFNTNLKEIVSQYKNFKDRLYIFRADLKNDGDEELFLLSKSLR
The following text describes a protein:
Function:
Involved in inositol deacylation of GPI-anchored proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MFMFRNCAVLLVIGSICCFIYGLFRLHVEVEPNACRMTYMFGEPMFAKVGVRDGDQYPNYALYYYYEGLRQPLDPLKRRMTGAPVIFVPGNAGSYKQVRSLASVALRKAMSNDAGIHLDYYTIDYDEELSALYGGYLHRQQSYLKLCIRTILSIYEGRTEQPSIVLIGHSMGGKLAQSVLVDPAIGQHINTIISISTPLDQPVLNLDTQLEEFYDQTDAVLSKLRTATVPTMTTNVCDSLHQRPPSVQRMASQDSSARLDNVLLISTGGGNRDLLVRPGLTSSRFNDLHAMTSAIPKVSLSCDHLSAVWCLQFMQAINRFLFSVAYVREDRSSIAFGTNKQRNLQTALSTFVKPRRRQQNTVRFGAAGNWHEERRLVINKYFTNGLKGTFFDLIGLQRQERYRKAAIEALNVDDEDWLFGCSAEDNNKTGQLYCEKATSLMHLVQWLPNEDREPRSIALLDLHNLRKTYVHWTHLLVRLPPSAKRIGYNLDIYDPKERVTDIKMPRWYTMAKLPLINETLQGTLHHRVRISEMVDPYQSIRVIVEPLQCINPEYRVTARICVPWAAGFERFQTLKSFDQKPQLYVNVPTLVPRHYNTTLNPVTLELYLDPTCRYRISYEYSYSSALSRLVLEFYGWLPAHLVCVLLIVLRKQVETFYDVGTFRSLRPYVGYLQYTSLYIVTACRLLKKLIISSRVFPEPEPLDYSINVSIVIHCAAIALSLLATLGTWLALTLYGNAFYRLALRITRLSQATSNVMISIMTHLPITYGILTIATAMGTCSGVGLLLAFVFYFLMLSNAYKDYLEDFLWQKAANLVRGKPSAVTEQEDATEEQNEEQNALKQNDEQKQQQQEEEEPEACVGLQNFSFHVTLLLMLFVQLLLNAPSSLAWLRSRRHGINLPDPSLYPSIVVLASLSLLLQLRAPQKCQGYWMLSIAFYILAGVVLLYCQAAIYRLTYVIAGAFALLSAHQSLWILWGRVSRV
The following text describes a protein:
Function:
Is probably involved in a pathway contributing to genomic integrity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MGIFTHSAEDDVLVSASFPETNAFGNVVNGEDNNILIHLINSGSKNYTLVSASASYHDPANHWALVKNATTLKYGVPLVSGANFSAPYHVYSEFRPQELGLTVTVNLAETGTKDLHYITAMNRTVSIVEAPGSWLDFQLIFLYLILGTALTLGGWWAYDSYFAPKSKVKGKKKSGPGPKKVQAVVPGKESVYPEVKPYEEEWIPEQLLKSKQNKLKKRNVDGASSAGEITSGGETSGAEGKGKKRKGKKA
The following text describes a protein:
Function:
Probable zinc protease.
Sequence:
MHTILHAFWLLLYTHVCSAAVYPFSQQLLSSNVHTQQFPARAQLMGTPKPVRTYDFVGKHRIRRITRDAVELSFNAYNQTLTLHLLPNHQLVHQNAMVEIHDLESSQTPIYMPILSSNVFDGKVIKTLFDGSRVENGWARITFNTPNFDNGEEVLFDGVIQSGSNMLHVKQIKHYKISQRQMDIEVASPFSRQPDSWGANMMVFTDEAQAVVEERWGPVSVCQASDSDHPLNRPNLNDSFIVPPLTGACELPDNSAVYNRYLDDMRLNDERRLFTRAAAGCPQTMQVLPMGVAADCSYVQAYGSTGAALAQILSNWNQASKIYESTFNVQLAVVKVSLQQSCTPTNPQMIWNQDCTSGYTITTRLSDFSNWRGNIEGNGDGIGLWHLMTKCSTQPAVGVAWLNMLCSNTATKQTSAGVDQFVSGTGVSSIVPVEWKVVAHEIGHNFGALHDCMSSTCPCSGPTSSCQCTPCSPQCDCRGQFIMHPLDNAATSAFSPASIESICSQYPTIGKCLKAPGTLSTISTGICGNSVKEADEECDCGLPADCAKDPCCDGTVCKLKAPAKCDDLNDSCCSNCQLKTAGTVCHPSLGSCDTTMTCNGLNATCPTNSSIADGTSCNTSSGVGAQCASGVCTNRDLQCKGSGSVVTVSACPSFSSSCALFCQNSAGNCFLLNGYFLDGTPCGYTGKCSNGACVGGNPAGFILEWIQSYPQYAVPLIVIGALLLIAVIYSCCRCCCSRPRKPVPQPARQSRSGSLRPSATTLYPPMAAPPPPFQPAITQDLPPYNPSYSSQPQTTAQPNGWVNPAAYNGFGEAQQPNTHSSGNRPPTMVVNNTQQ
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
RPRLPPPPFLLPAEAPAGQTGALTLPRAHISARPARDPTSSGEQAAALLVTFVTFLGPPGWILAHFDSYKQGSA
The following text describes a protein:
Function:
Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.
Subcellular Localization:
Nucleus.
Sequence:
MAEDATKNLGKFAQPSNFHSIGYDAKMGRVKSDDPYLLSSDTPLQHDVDFGITQSKDTSNIADLLNSGTSRSDTTVSFYGLGDIGSDMKSKKSRIIPPALDICSHYSTGINNPLPSPNNLSWLTDLAIIATSPQSPLMQATYQNAAKNRDQINTLEDQLKRRGNSDYNLLGSGQIIRKEAMESKGEFGGDHASITPSWLCFMKGTKIKFSASNQQVSWIAAEELGKNDKLVRQLGQIEGPTTYAPFGLKLMEVKEIKGNSDKRKRKNLLIMRFSSTVNGQPRIAARCLADHPFYVKEKGWSSFCPELTNSQYGINSKFLKINDVCIPPPSNAEAFKFDKLNLTAMDSSAALTLSRMGMAKKYKSDESPMGSPSKKSNGSDNGSNSSNQQSRMQSDRAKRPMNAFMLFAKKYRVEITQAHPGKDNRAISVILGDKWKSMETTERQQYAEKARILAEEHKKNFPDCWKRKKTLKVTISYLFCSVLISLRTLY
The following text describes a protein:
Function:
GTPase-activating protein, which inhibits the vulval induction by acting as a negative regulator for the member of the Ras family let-60. Probably decreases the signaling activity of Ras by stimulating its intrinsic GTPase activity, thereby lowering the levels of GTP-bound, active Ras.
Subcellular Localization:
Cytoplasm.
Sequence:
MVLSCRVVDCGGLKLKENQTLLLLVSTIHNSSEVGKLSIDAEEKRSKEWLEMPCAEGMLSLKLTLWQDLLKGINSVFHGQVRVDVDENWKSGPAKWFYLRSKANEDGEGGEDGGDIGDATVKVTYQIDHILRMQVYKPLLDLLFLAGDVQPLTASLVAVIEALPKVELGPVSRSLVELMAQSDRIRPVLSSLYVNSILKCQDENTLFRGQSLSGKMLFEILTTYGKMYLITTLKPVVDKIYKERKNCEVDPARVAVGASLEKNRNNLLVYFQMLFERVTTSSTNCPHLIKQLLYDLRNVVGTHSSRSGVQRLAVSSFVIMRFFAAAILNPKAFEIRKDQPDLRVSRTLLLLSKLLQRLSNCSVSEGPLSSKEIWLNGVFETVTSEQHKSVMASFLDNISLVGDRSEPQKCTVFKFGNLQQVDRSRLAWKKVLHYKKRYVQLTNTHLIWQKDVQCAPKGTVPLSDIKFVNVDNKNIITIVCETMQLQFEAPGGVEATDWLNAIERQRNRAAHEIAETPGEHFFVDAERHVDKIHTLLYKYRETMIEWRDQLQSNVELDEKTAPELLKASYVVEEERQSHKDSLIATLCSTIDVTDAIQLAHTEYEKENKVSRRIDAIITAKKRQKSFSVK
The following text describes a protein:
Function:
Involved in the metabolism of ADP-ribose 1',2'-cyclic phosphate which is produced as a consequence of tRNA splicing.
Subcellular Localization:
Golgi apparatus.
Sequence:
MGVALWLCPKRNTPTYDKLITVMSSLNTLFPGSPPKFEPHITITTNISLDLADQSKTKDDVDRILSASAVAMNSLPKNHESLVKLGNVNSQRKFFKKLYFEVEKDPNLVSFARIIRELFVIVPQDIEKENIKQNPQLYTKDNNGNTIRRKPSKKKSKTTEVKEFDTSFIRQAAAYKAAEWSVQEFDPHISLVYSDLWPLHSALWRNINTRISDIDWDIEWEFGVLKLVLCEGDVNDWVVLGSVDIH
The following text describes a protein:
Function:
Promotes the exchange of Ras-bound GDP by GTP (By similarity). Seems to play a role in chemotaxis.
Sequence:
MDHTECNNRIEYLQNKVLELESLNENLKGQLEYFQTKFLESNLNSEGKDISSCLTEIYNSLSLDNNNNNSNSNSNSNNNSSNSNNNSYSNFNSNNNTTNNTKVIKNRNFKINLTNSNSTNSSPYIFGNNKDNSNNSNNSNNNNSNTELSNDHLSLEDNIATTNTTTTTTINTSNSNNSNNNNNNNNNNNNNNNNNNNNNNKPTSNRPPVAPRSFIRSNSDTFITPPGSPTSSRNSPTNKSSPQFLSPLSKSPLSQSTQSTTVSSPSPSWTTTVPQSKMRSETIVQSKSPYSPDTNISNKLINELASNIGAPNSNGSESPSKNSPRSLNSNNNNSSATTSITTPPTTSTPTPTTSTTTTTTTERRPEDRRSKTSPFPNVGTTTPPLSNSAHLVRTQSASGANAVKPQSQLSTSCTVNMIGGGGTPRSNNSSNGSLYHSMSSNGLIENLSTSSSLSLSSTSPSPNNSQQNLTNPFEIGADDELEVLDDPRLVMVKTENGFIVKGGTIEKLVNRLIAKHDPDFTSAFLLTHKSFTTSIELLDLLIEFYVNNKDSSSINSNSSSSSSSAVASSSFSNINCNISDLSSSTSSTNSLLINSITNSPIINSNNQNNQNNNNNNNNNNNNNNNQLEINGDKKKKAIRLKITNVIKSWVDKHYYDFSEDKQLTLKLDQFITNHIMFDMDKIGFNLKRLLTNDRVVPVPTFTQGPPTPIPPKMKSNGSEINFKDLDPTEIARQLTLYESDLFRKIGAKECLGQAWNKDGKEENAPNIVSFIKRFNQVSSWVATEIVRQEKLKDRVSYIKRFILVAQECRKLNNFNATMEILSGLQNSSVYRLRKTWERVESKPLLKNTLDELMSLMSSGANYKNYIQELHNIHPPCIPYLGVYLTHLTFIEDGMKNVLTTTTATTTNTTTTTTTTTTTTTTNTTTSNNNNQQQLNGANRSFDDVIINFEKCRKISVVIREIKQYQQQQYHLHTEEFTLRYLSNLPSIQTQKSMYKLSLICEPKEKETSSFDSGYGSVSDRPSKKEFSVTSLLNSFKS
The following text describes a protein:
Function:
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
Subcellular Localization:
Nucleus.
Sequence:
MAAGKRKAHNNVTEYAWDSRDEYFDVKAVKLDDQYLAEQKKALVSNLFHGVSIHINGYTNPSAEVLKQLIMIHGGNFQQYYSKSRVTHIIASNLPDVKIKDLKKEIVVKPSWIVDSIQNGKILPIYNYLLVDGRSASQTKIQFTEANSSGKNKNNNTNCNSSCSNNSTTVKSQNIKTDSPKAKEKFPPGIANTADPEFVSQFYSRSRLHYLATWKSEWKNYASTLDRNIDLDNRRDEIRQRIIDLKSSRSSTIKHENHEVTVKEEPLQSSADQAIIESPNSQNTGRKNLFNRVVMHLDMDSFFVSVAIRDRADLRGLPVAVTHSKGKIKPANLQNADKLQEKAEFIQEMAHWEDYHSKDKVKAEKASHDSPSKSNKINNNFISANDKESVEQFSTSEIASCNYVARRYGLHNGMFMGRALQLCPHLRVVPYEFDKYKEVSKLLYNTLASYTFEIMAISCDEAYIDVTDILQDDYTIQDLASSIRHDIESKTGCTCSAGIGPNLLIARMATRIAKPNGQHYVDPANVLTFVANQSLKDLPGVGYRLHRKLKDLNVETCQDLRKISLPVLQRDFGTKTGLMLYQYCRGIDERPVQVDHERKSVSAEINYGIRFAEMKHRSPDASIKPWKYLGHGKCDNYAKSTTLTRPTCDSDIISKECMKLFYSFASINVQDVRGMGIQIQRLSPIDEDVKGSQGLLNFIKSVPQVEENVKAHEQIEPSDQIEVIHDQSIPTTSIAKQEEITDSNRHIEAQNDESFDLPSPSQLDHSVLDALPKEMRLKIEQKYAKMSSEAQIKVEPSTSATIDANSSIDPINLGAIADVYRHINYNEEIPRKNVKQRKKPKRNIKNKFRRNKSDQSIPKENKEDKLDRDIIVLDSTERKPKILPDQTNVIEPEFCGATEINEVKKIMAEWVDACLDVGPTETDIEYLMSYVERCISSKNLENVWLLCKLLKRKTVAHAAWYQIFTSILDRIQDIVSSQYDGSRLDYLFKRRFVLGWSRGENRFAKEMIYSKKLT
The following text describes a protein:
Function:
Component of the heterodimer clotting factor G which may play a role in defense mechanisms against fungi (Probable). Initiates a (1->3)-beta-glucan-sensing clotting pathway whereby the alpha subunit binds to glucans containing (1->3)-beta linkages, which are components of the fungal cell wall, and the beta subunit catalyzes the activation of proclotting enzyme.
Sequence:
MLVLLCCVVLHVGVARICCSHEPKWQLVWSDEFTNGISSDWEFEMGNGLNGWGNNELQYYRRENAQVEGGKLVITAKREDYDGFKYTSARLKTQFDKSWKYGKIEAKMAIPSFRGVWVMFWMSGDNTNYVRWPSSGEIDFIEHRNTNNEKVRGTIHWSTPDGAHAHHNRESNTNGIDYHIYSVEWNSSIVKWFVNGNQYFEVKIQGGVNGKSAFRNKVFVILNMAIGGNWPGFDVADEAFPAKMYIDYVRVYQDASTSSPVGDTSLDGYYFVQNRHSELYLDVTDASNEDGAFLQQWSYSGNENQQFDFEHLENNVYKITNKKSGKSLDVYNFGTENGVRIQQWSYGGARNQQFTVQSVGDGYYKIIPRGSGKLVEVADFSKDAGGKIQQWSDNNQLSGQWKLIKSKSYSKLIQAESYFDSSKVQLEDTSDVGGGKNVKCDNEGAWMAYKDIDFPSSGNYRIEYRVASERAGGKLSLDLNAGSIVLGMLDVPSTGGWQKWTTISHTVNVDSGTYNLGIYVQRASWNINWIKITKIPEQSNLNQGRRNSKLIQAESYFSYSEVQLEDTLDVGGGKNVKCDKEGAWMAYKDIDFPSSGSYRVEYRVASERAGGKLSLDLNAGSIVLGMLDIPSTGGLQKWTTISHIVNVDLGTYNLGIYVQKASWNINWIRITKV
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
IFHWQPNAGTTINSQILIEVANCAESINGVKEGRWRNTFTFYKPILKEQANALEFPQNFLGVSLQEQPDKFYMAISRNDWLWKQTIMENLQSYRMKLAVNCEMEYLPISSWETSHLIMSEFFEIWKETLGKRSLPGHFVHVEPKFSKFGLSDQYTSQHTVVQDAIMAATSQSSGSNISIITSN