lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
One of the multiple factors required for polyadenylation and 3'-end cleavage of pre-mRNAs (By similarity). Required for the targeted 3' processing of antisense transcripts that triggers transcriptional silencing of the corresponding sense gene.
Subcellular Localization:
Nucleus.
Sequence:
MADKYIVEEAEALAKRALHSPIAQATPIYEQLLSLYPTSARFWKQYVEAQMAVNNDDATKQIFSRCLLTCLQVPLWQCYIRFIRKVYDKKGAEGQEETTKAFEFMLNYIGTDIASGPIWTEYIAFLKSLPALNLNEDLHRKTALRKVYHRAILTPTHHVEQLWKDYENFENTVNRQLAKGLVNEYQPKFNSARAVYRERKKYIEEIDWNMLAVPPTGTSKEETQWVAWKKFLSFEKGNPQRIDTASSTKRIIYAYEQCLMCLYHYPDVWYDYAEWHVKSGSTDAAIKVFQRALKAIPDSEMLKYAFAEMEESRGAIQSAKKLYENILGASTNSLAHIQYLRFLRRAEGVEAARKYFLDARKSPSCTYHVYIAFATMAFCIDKEPKVAHNIFEEGLKLYMSEPVYILKYADFLTRLNDDRNIRALFERALSTLPVEDSAEVWKRFIQFEQTYGDLASILKVEQRMKEALSGKGEEGSSPPESSLQDVVSRYSYMDLWPCTSNDLDHLARQELLVKNLNKKAGKTNLPHVPAAIGSVASSSKVVYPDTSQMVVQDPTKKSEFASSANPVAASASNTFPSTVTATATHGSASTFDEIPKTTPPALVAFLANLPIVDGPTPNVDVVLSICLQSDFPTGQTVKQSFAAKGNPPSQNDPSGPTRGVSQRLPRDRRATKRKDSDRQEEDDTATVQSQPLPTDVFRLRQMRKARGIATSSQTPTGSTSYGSAFSGELSGSTG
The following text describes a protein:
Function:
Required for brassinosteroid- (BR) mediated post-transcriptional and translational regulation in the chloroplast, including accumulation of chloroplast rRNA. Involved in chloroplast differentiation.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MVVLISSTVTICNVKPKLEDGNFRVSRLIHRPEVPFFSGLSNEKKKKCAVSVMCLAVKKEQVVQSVESVNGTIFPKKSKNLIMSEGRDEDEDYGKIICPGCGIFMQDNDPDLPGYYQKRKVIANNLEGDEHVENDELAGFEMVDDDADEEEEGEDDEMDDEIKNAIEGSNSESESGFEWESDEWEEKKEVNDVELDGFAPAGVGYGNVTEEKEKKKRVSKTERKKIAREEAKKDNYDDVTVCARCHSLRNYGQVKNQAAENLLPDFDFDRLISTRLIKPMSNSSTTVVVMVVDCVDFDGSFPKRAAKSLFQVLQKAENDPKGSKNLPKLVLVATKVDLLPTQISPARLDRWVRHRAKAGGAPKLSGVYMVSARKDIGVKNLLAYIKELAGPRGNVWVIGAQNAGKSTLINALSKKDGAKVTRLTEAPVPGTTLGILKIGGILSAKAKMYDTPGLLHPYLMSLRLNSEERKMVEIRKEVQPRSYRVKAGQSVHIGGLVRLDLVSASVETIYITIWASHSVSLHLGKTENAEEIFKGHSGLRLQPPIGENRASELGTWEEKEIQVSGNSWDVKSIDISVAGLGWLSLGLKGAATLALWTYQGIDVTLREPLVIDRAPYLERPGFWLPKAITEVLGTHSSKLVDARRRKKQQDSTDFLSDSVA
The following text describes a protein:
Function:
Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MLLVRATRSVLRKSVMRKTMIVPSLLATLLHHHFPLVLREVRRKRQTVDDEEVEIKDADGEEMVGWSDDDGEGVITPPIKSKNEVEKLPEVPPVDVALEPHNQILPVGVILSIIGAKVVEGTEKNNPLNEGSILWITETRLPLGLADEIFGPVKNPYYVVRYNLDKEVPDGISQGTPVSFVEEFANHVLNEKNLYKKGYDTSGENNEVFDEAEFSDDQRRLSARECKGWQSGVQMIRNAETLILLIRRNLNTRTGPGRATSFQFLQHYL
The following text describes a protein:
Function:
Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity).
Miscellaneous:
MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).
Sequence:
MSRQLNLYPGGERLAFSGCSAIISSRVSSSTASFRASGIKGTATFGSRSLFNCGGGRRPALSSAAGRGGSALGSCAATGGGRRGGFVGTVFGSAGLGPACPSVCPPGGIPQVTVNKSLLSPLNVELDPEIQKVRAQEREQIKALNNKFASFIDKVRFLEQQNQVLGTKWELLQQLDLNNCKNNLEPILEGYTSNLRKQLEMLSGDRVRLDSELRSMRDVVEEYKKRYEVEINRRTAAENEFVMLKKDVDAAYMNKVELQAKVDSLTDEIKFLKCLYEGEIAQLQSHISDTSVILSMDNNRDLDLDSIIAQVRAQYEEIALKSKAEAEALYQTKIQELQATAGQHGDDLKLTKAEISDLNRMIQRIRSEIGNVKKQCSNLEMAIADAEQRGDCALKDARAKLDELDAALLQAKEELARMMREYQELMSTKLALDMEIATYRKLLEGEECRMSGEYPNSVSISVISNTSTGAGGTGFSMGFGALSSYSYKSSAVDVKTKGSCGGSELKDAPAKTSGSSCATKKASR
The following text describes a protein:
Function:
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
Sequence:
MVRLVFPRHLSALIGHVQYALLQAKEQGVAIQHIRLDVGSEAQFILEKSEESLRIGSSLCSQKEGFEPCDYYLDYVSENRVLPEAMMCNARCTVTVGLHDEYGFTLDKWQYGHAAEQLIVYPSENHRLNSKVNQHLAWVLATLTLDFSIGDGLCIARAAITQGDSVSRETWPTQFERFPAVQSNIRSLSTQVFLTTRAFPTIDKAKFNLYPVVDDVNWIEHLLKLGVRTVQLRIKDPKQGDLEAQIIRAIALGREFNAQVFINDHWQLAIKHQAYGVHLGQEDLTSANLTELLDAGIRLGLSTHGYYELLIAAGIQPSYIALGHIFPTTTKQMPSKPQGLVRLAAYQRLVNQMPYQGQHGIPTVAIGGIDCRNIRDVLDCGVTAVAVVRAITESPDPSLAVQALSSAFADFVDAEYKLMPASESCEPLSYLAMEVADAHR
The following text describes a protein:
Function:
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKSHQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIKVVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVLFMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFLVFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFKTTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL
The following text describes a protein:
Function:
Involved in oxidative stress response and redox homeostasis. Required for hydrogen peroxide-induced oxidation and nuclear localization (activation) of CAP1. Functions probably in concert with GPX3, the actual CAP1 modifying enzyme.
Subcellular Localization:
Cytoplasm.
Sequence:
MENLESGAQDALQSKDFLSYSTLLDIYLNDPTKYSNEEKEQLLGHILTILSENKQLTYEIGWDLPQLLILYVDSDYEFNGPIRDSPGVYKILKIFENLAINGNHKELFLKSCELLNDLELSQDEDIELLKRENFFEIKLYCVFELIDACLKKIHTLYPSRFLAMTVSSFNNLMFKLTKQHGSLGNYHFVMKRVYSFCRNYISPPLPTNAKEMPQEELDKIVKDEEYLQRRLLTGFLTQVIYLANINGTEGYSIEHFSWLQQQSKSKIKFVFERDGAFCDRFVELASSFDIDLLKCFQGFITDSHKLLIGIDYKNKNKSEDEIIELLFERVVVDYQKNVLTSIVDSDAKAIKDSIIGELILFTHSIAGKKNFAKPTMSIHDSLVMTLRLIIPQMVNPKFINAGNHDVVVFWVWFALYQQQIINSKNLQLEISYIPKVLLTTFFQCLLFIVIKSEGKPNFKYMLLTLLTKLLTLSPDTGYEFIKDSLNNCPYESVYPSLIGVYKQLLLNEKWDVNSIELEKLNISSSSSNTPPKLPPRNGIKRKHFSLTNESLNDLVDLINNSSKNAFVEDNSKIDPSKLSTIAAYLNLLVAIKKDPVIVENKEKLTTLISSIENKIKSVKKSSQNQFELNAAGMLEITIERFNE
The following text describes a protein:
Function:
Cleaves the beta-phosphate at the 5-position of soluble inositol pyrophosphates. Has highest activity on 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate (5-InsP(7)), 1,5-bis-diphosphoinositol 2,3,4,6-tetrakisphosphate (1,5-InsP(8)) and 3,5-InsP(8). Possesses phosphotyrosine phosphatase activity in vitro. Dephosphorylates the phosphoinositides PI(3,5)P2. Hydrolyzes para-nitrophenyl phosphate and O-methylfluorescein phosphate in vitro.
Subcellular Localization:
Nucleus.
Sequence:
MCLIMETDDHNGDVLAPPSNFSMVEDGIYRSGFPRPENFSFLKTLNLRSIIYLCPEPYPEENLKFLEANNIKLYQFGIEGKTDPPTPMPKDTVLDALKVLVDVRNHPILIHCKRGKHRTGCLVGCLRKVQSWCLSSVLEEYQKNAGLKWRQRDLNFIEAFDIVSLRQCLLSIMYQYHGYGFKRRRLAYEEENVKTPKPQAARV
The following text describes a protein:
Function:
Copper chaperone for superoxide dismutase 1 (sod1). Binds copper ions and delivers them specifically to sod1. Also has a role in cell protection against copper ion toxicity during conditions of copper excess. The C-terminal region is thought to act specifically in this sequestration role.
Subcellular Localization:
Cytoplasm.
Sequence:
MFEVEYLIKDCDDVNKNTLEQEFQDLNIEDWKWDAATGQLIVKGSVSPSKVLRRLENATSKPILIRGASNKESGVSILYEANEDITQIPKVYGLCRFIPTEEKIFLDLIATQLLPNREYTGLVTISGDISRGLKSAGDSLVTLFNANSNEQGKIVLDKEVSGSLPNWIGHCFVLKCVDDSDSATMGIISRSAGLGQNTKQICACTGKSLWTEHAELKSVNEGSSCCSKKDSSPSEKPSCCSQEKKSCCSSKKPSCCSQEKKGCCSTEKTSCCSQEKKSCCTSEKPSCCSNGKSTVCA
The following text describes a protein:
Function:
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).
Subcellular Localization:
Mitochondrion.
Sequence:
MAFLSACTSWRHVHNAGFTFITKFPFVRNVHKLSYHISPLSSRFSLADISVKENNHPNGPQLRLQTHFFHSSSPMHATKGFRFPKSSTPLTLPAVLSVASFANLLQIPTRRILRDLNRLGIKDVFPEYLITYEYSSLLAEEYGFDVQEAAAYSAPSPKSLNSKKDSGPLRPPVVTLMGHVDHGKTTLLDAFRKSTIASTEHGGITQKIGAFTVPFDKGSKFITFLDTPGHMAFEAMRKRGANIADIVVLVVAGDDGVKPQTVEAIKHIQSADVPVVVALTKSDRPGTPIHKIYEQLLNNGIQVEALGGETQIIPISAKTGKGIPELEAAILTLAEIMEIRASPRDPFQGWIVESSVTKGVGSSATVVVKRGTVKKGMYLVAGKSWCKVRSLVDVNKKSIKQVLPGQAAQVYGWKDLPIAGDLAYEVKSESEAKRILSDIYRQSNEQNFYELAESQNEQRVSALAAKKSGPAAIQEETSVSKSFNIIAKCEDTGSMEALSDYLKPLQFGKVKSRVLYTGVGPVTETDIERAETSDAIIISFGVSVPKATFRLAEKHNVKLLFHNVIYHLMDDVRKLFALRLPPILVQRVTGEAIISAIFDIKAKRAVVHVAGCRVTNGTIEKSHKIRLVRNDKIIWSGEIDSLKHLKEEVTSIKKGRECGILLKNFDEIVTGDKLQTFVEEYKPPDF
The following text describes a protein:
Function:
Trans-acting regulatory protein that activates transcription of the MT genes (metallothionein) in response to copper or silver ions.
Subcellular Localization:
Nucleus.
Sequence:
MVVINGVKYACDSCIKSHKAAQCEHNDRPLKILKPRGRPPTTCDHCKDMRKTKNVNPSGSCNCSKLEKIRQEKGITIEEDMLMSGNMDMCLCVRGEPCRCHARRKRTQKSNKKDNLSINSPTNNSPSPALSVNIGGMVVANDDILKSLGPIQNVDLTAPLDFPPNGIDNKPMESFYTQTSKSDAVDSLEFDHLMNMQMRNDNSLSFPMSANQNEVGYQFNNEGNNSMNSTMKNTITQMDQGNSHSMTLHDIDEILNNGIELGNVN
The following text describes a protein:
Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MPGRGSLEDDPFDFLFKIILIGDSNVGKTCVVHRFQSGIFMDNQQNTIGVDFTVRSLNINGKKVKVQVWDTAGQERFRTITQSYYRSAHGAIIAYDITRRQSFESVPHWIYEAGKYGAANLMLMLMGNKSDLAEKRQILFEEACTLAEKHGLLAVLETSAKESHNVDEVFLLMAKELIARNTFHYHNESPRNSFILDSKPVLAPPEPDKSCLC
The following text describes a protein:
Function:
Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
Subcellular Localization:
Cytoplasm.
Sequence:
MTERLTAREFLALVTDDATFSELPHADGPWRPDGPLGWPGYDASRARAAERTGEAESVVCGTGLVEGTRAVLVSFEFGFLGGSLGHRTGDRLEAAYAYAREHRLPVVPLVATGGSRMQEGMLALTQLQRVARQSALTRAAGLAQIAVVRDPATGGGWATLGAGADVVLALPGAQVGFAGSRVRPPDADPAAYTAEAQVAAGSADAVVPPGELRATLGRWLRLLTAPSGGPAPVPEPLGARDLPAGGWEAVRRARDPGRPRAGAYLDAYFTDRVALSGDRCGGRDPEGMLCGFGSHAGRTVAYAAQTGTATRPAGYRTATRLIHLADRLGIPVLTLVDTPGAANDAEAERAGAGPAIADLFGAVASARTPVTTLVIGEGGSGGALALAAPGSTWATPDSYFSVIAPEHAAAILKRPPAEVEATAGQLRLRPQDLAALGVIRTSEQLFPGTGDRRSEERM
The following text describes a protein:
Function:
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
Sequence:
MGNLIKELQDEQCRTDLADFCVGDTIRVATNISEGGKERVQVFQGTVMARKGGGAGETVSLHRVAYGEGMEKSFLLNSPKIVSIEVVKRGKVSRARLFYLRGKTGKAAKVKELIGSRAAKK
The following text describes a protein:
Function:
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
Subcellular Localization:
Cytoplasm.
Sequence:
MRRIILASASPRRKELLKQLIGDNFVVYPSSYEEPPQPGLDPEELLLKHSVEKARDVAKHFDSGLVISADTSVLCEGEVLGKPGSPENAEKMLEKLSGKKFRVITGLTVLDLDSGKETSEFESTNVWLAELSKEQILAYVRTGEPLDKAGAFAAQGKGAVLVEKVEGDFFNAVGLPLFRLGKILERLGVSVFDEGFS
The following text describes a protein:
Function:
Transcriptional repressor that binds to E2f sites and represses E2f-regulated target genes. Binding to E2f sites requires transcription factor Dp. Acts synergistically with Rbf2 to antagonize E2f1-mediated transcriptional activation. Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. The DREAM complex is required for recruiting E2f2 at differentiation-specific promoters and for stabilizing E2f2-Rbf complexes during S phase. During development, the complex represses transcription of developmentally controlled E2f target genes. During oogenesis, plays a role in restricting DNA synthesis to sites of chorion gene amplification in late stage ovarian follicle cells. Plays an inhibitory role in ionizing radiation (IR)-induced p53-independent apoptosis. May be involved in cell cycle exit by temporarily limiting CycE-dependent activation of E2f-regulated transcription.
Subcellular Localization:
Nucleus.
Sequence:
MYKRKTASIVKRDSSAAGTTSSAMMMKVDSAETSVRSQSYESTPVSMDTSPDPPTPIKSPSNSQSQSQPGQQRSVGSLVLLTQKFVDLVKANEGSIDLKAATKILDVQKRRIYDITNVLEGIGLIDKGRHCSLVRWRGGGFNNAKDQENYDLARSRTNHLKMLEDDLDRQLEYAQRNLRYVMQDPSNRSYAYVTRDDLLDIFGDDSVFTIPNYDEEVDIKRNHYELAVSLDNGSAIDIRLVTNQGKSTTNPHDVDGFFDYHRLDTPSPSTSSHSSEDGNAPACAGNVITDEHGYSCNPGMKDEMKLLENELTAKIIFQNYLSGHSLRRFYPDDPNLENPPLLQLNPPQEDFNFALKSDEGICELFDVQCS
The following text describes a protein:
Function:
Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor. Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling. Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits. Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes.
Subcellular Localization:
Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, stereocilium. Cytoplasm. Membrane, clathrin-coated pit.
Sequence:
MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGIQKLASQYLKKDWPGIKADERNDYRSMYPVWKSFLEGTMQVAQSRINICENYKNLISEPARTVRNLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSEYNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELEACQAIQNTFQFLLETSSRVVRDYNLQLFLQENSVFHKPPPFQFHPSDSDTSLNAVQLVDIEPSPVSAMRMTIAESRQLESETGTTEEHSLNKEARKWATRVAREHKNIIHNQRALEELECHGVAVSEQNRAELEQKIDEARESIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENERWASLPAVANNGSLHLLHVDAEREEGEEFEDNMDAFDDSSSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSNSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDSSVCFVKALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGHVGVFPSVLVEELSASENGDTQWVREIQISPSPKPHNSLPPLPLYDQPPSSPSPSPDKRSSRYFPSSPPIKVKPGGHFFAFFFSLWGRTPPR
The following text describes a protein:
Function:
May play an important role in stabilizing and/or regulating the cell membrane during Ca(2+) stress or certain stages of development.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
LQADKDGSNIVNYCLNIKNGSKDQNTPVILWPIQKNSTNELWQLTSDGHIISRMFGNVVLDVGNSVDGSNSKFYVIINPNFNVNSDSQKWVVNSETNQISNKNFPNLYLGIDGAYNGPIAPVKYQNIVLAKPSDNSNPCFQWLFLPKSPFYKILSQKPEPFPTYEKDPQFAETYHLISKTITLDRTNSIRTQYSNTIAPLSSFQSSLVSMKCPKDVNPEVFEIVKDQINYELTCAISVQNLFATFSKFYTENYICSEASITNLALLCKLDSKKDLVTGFFKSFIDNTTTNILCMIPEIGPIFTEFVDIGYDLYADSGYSTNNISPFTVAVSQLYKRFYTNFINILKIIGEIETDILNDWGMMKTTYSCIMLPVGTPNSLFWNTNMNYELVNATSIANDIAILQVLMPSKYQIYYCSFGINYTNAPSYCQYWDNRKQFYYIAEIQDNNAFPDSELMKTYLWGNNVNQQEFYQSNFGWTFNTANNDVYKNRIYNQGLPTLFNGTSTPMYYNLVNNGTPVKCNVYTYSSGFFSGEYSTGLLGSHEYQIEIYDFNNNQLMSFTVSVDLPMMKGCTPRIVGSPTIASGYYFVNQLSCEGSRSQEFAGSLSFAIY
The following text describes a protein:
Function:
Required during somitogenesis to regulate somite differentiation and the positioning of the presomitic mesoderm-front. Represses the expression of genes involved in somite segmentation by acting with the corepressor tle4 to down-regulate the transcriptional activity of tbx6. Also regulates retinoic acid signaling during somitogenesis and is necessary for the expression of aldh1a2/raldh2.
Subcellular Localization:
Nucleus.
Domain:
The ripply homology domain is required for transcriptional repression; The WRPW motif is required for binding to tle/groucho proteins and transcriptional repression.
Sequence:
MEPNQQRSCGSSSDSSATGTPQGSNVAVWRPWHDAPRTHVQNPPTAQQQFYSDNQSHMNDKGKPPSFQHPVKLFWPKSRCYDFMYQEAEELLRHFPVQATISLYQETDSDSDSEEEDIYEN
The following text describes a protein:
Function:
Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques (By similarity).
Subcellular Localization:
Cell junction, desmosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Midbody. Cell membrane; Peripheral membrane protein. Note=Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells (By similarity).
Sequence:
MPAPEQGSLVEEGQPQTHQEAVSTGPGMEPETTATTILASVKEQELQFQRLTRELEVERQIVASQLERCRLGAESPSIASTSSTEKSFPWRSTDVPNPGVSKPRVSDTIHPNNYLIRTEPEQGTLYSPEQTSLHESEGSLGNSRSSTQMNSYSDSGYQEAGSFHNSQTVNKADSRQHPFTGSTSNHVVRTSRAEGQTLVQPSVANRAMRRVSSVPSRAQSPSYVTSTGVSPSRGSLRTSLGSGFGSPSVTDSRPLNPSAYSSSTLPAQRAASPYSQRPASPTAVRRVGSVTSRQTSNPNGPVPQYQTTTRVGSPLTLTDAQTRVASPSQGQVGSSSPKRSGMTAVPQHLGPSLQRTVHDMDQFGQQQYDIYERMVPPRPDSLTGLRSSYASQHSQLGQELRSAVSPDLHITPIYEGRTYYSPVYRSPNHGTVELQGSQTALYRTGSVGIGNLQRTSSQRSTLTYQRNNYALNTAATYAEPYRPVQYRVQECSYNRLQHTGPADDGATRSPSIDSIQKDPREFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVLWNLSSCDAVKMTIIRDALSTLTNTVIVPHSGWNNSSFDDDHKIKFQTSLVLRNTTGCLRNLSSAGEEARKQMRSCEGLVDSLLYVIHTCVNTSDYDSKTVENCVCTLRNLSYRLELEVPQARLLGLNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWDGVGPIPGLSKSPKGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDLVNRLPGGNGPSILSDETVAAICCALHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSLKVVKAAAQVLNTLWQYRDLRSIYKKDGWNQNHFITPVSTLERDRFKSHPSLSTTNQQMSPIIQSVGSTSSSPALLGIREPRSEYDRTQPPMQYYNSQGDTTHKGLYPGSSKPSPIYISSYSSPAREQNRRLQHQQLYYQDDSTRKTLDAYRLYLQSPRSYEDPYCDDRVHFPASTDYSTQYGLKSTTNYVDFYSTKRPSYRAEQYPGSPDSWV
The following text describes a protein:
Function:
Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-6', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5.
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MMITADLIWDENLDNDCEVSKDIWEDDTFIDKSYLKVVLPSYDGVDTPIVYHFKLNDDLKINSIKIPTNSIGNLGKFGRLNTCSLEAVSGEPPVLKEIIIKIDERLYDKLALLPKANEKKQYFQIKYNLVNKQSVIHEGNIWGHVCEVVETKPFSQGVIDFSVTDIVLIRSKILSVENKHDRSLVNLQAFHDLSRIPLKCLHYPVERSLLLPEPPFDDDDSIYVFFPFDLLSKLKISSGSFVRLSNSKNSVLVRAFLLQSPNHYAVDGIYTTPFVLAQFDELPLVEVEPVYNNELAFPTASEVVISKVGNVLHTQKRYQELILQKLRYYFLTARRILSNGSLIPITIDSSFDEIILEDIDLDVNTIKSDDDCIVWFVVSNRKFENISNYDPKAEFFVDPKHTKLITSAMENRSLSSNTFNSALKYYGLPGVFHYRPDIFPVVNDIKNVINTHAEANKKVPNLPMILNLSSNVPKVGKASILRSIAIDLSYQFVDIDTLSVVFSSGSSDIATTFLGYLKGKLENLLPFTGNTIILIKHIDHILKKVDQNQDIQQSRQVKALEGDLISFIKSYSRIYPGVVFAFTSASIDNLPEGFRSEIKFDYVVHPPNEKQRRSIIDELLSTSDLFQKYGNRKLRIQCSNEIEISTLSLHSAGLSPYDIQYIISLAVADSLRKCNNYLLWRQNKIKVDMISIQNALEKVRSDYSASIGAPSIPNVTWDDVGGLSSVKDAIMETIDLPLKHPELFGSGLKKRSGILFYGPPGTGKTLLAKAIATNFSLNFFSVKGPELLNMYIGESEANVRRVFQKARDAKPCVIFFDEVDSVAPKRGNQGDSGGVMDRIVSQLLAELDGMSSDGDGVFIIGATNRPDLLDEALLRPGRFDKLIYLGIADTREKQANIMRALTRKFKVSSDINFDELVSDFPFSYTGADFYALCSDAMLKAMTRISKEIDEKVDKYNQDNGTSISIRYWFDHVCSDEDTDVIVKKEDFLNANKELIPSVSQQELEHYKQIRANFEDSK
The following text describes a protein:
Function:
Probable receptor, TonB-dependent.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MKKAIKLNLITLGLINTIGMTITQAQAEETLGQIDVVEKVISNDKKPFTEAKAKSTRENVFKETQTIDQVIRSIPGAFTQQDKGSGVVSVNIRGENGLGRVNTMVDGVTQTFYSTALDSGQSGGSSQFGAAIDPNFIAGVDVNKSNFSGASGINALAGSANFRTLGVNDVITDDKPFGIILKGMTGSNATKSNFMTMAAGRKWLDNGGYVGVVYGYSQREVSQDYRIGGGERLASLGQDILAKEKEAYFRNAGYILNPEGQWTPDLSKKHWSCNKPDYQKNGDCSYYRIGSAAKTRREILQELLTNGKKPKDIEKLQKGNDGIEETDKSFERNKDQYSVAPIEPGSLQSRSRSHLLKFEYGDDHQNLGAQLRTLDNKIGSRKIENRNYQVNYNFNNNSYLDLNLMAAHNIGKTIYPKGGFFAGWQVADKLITKNVANIVDINNSHTFLLPKEIDLKTTLGFNYFTNEYSKNRFPEELSLFYNDASHDQGLYSHSKRGRYSGTKSLLPQRSVILQPSGKQKFKTVYFDTALSKGIYHLNYSVNFTHYAFNGEYVGYENTAGQQINEPILHKSGHKKAFNHSATLSAELSDYFMPFFTYSRTHRMPNIQEMFFSQVSNAGVNTALKPEQSDTYQLGFNTYKKGLFTQDDVLGVKLVGYRSFIKNYIHNVYGVWWRDGMPTWAESNGFKYTIAHQNYKPIVKKSGVELEINYDMGRFFANVSYAYQRTNQPTNYADASPRPNNASQEDILKQGYGLSRVSMLPKDYGRLELGTRWFDQKLTLGLAARYYGKSKRATIEEEYINGSRFKKNTLRRENYYAVKKTEDIKKQPIILDLHVSYEPIKDLIIKAEVQNLLDKRYVDPLDAGNDAASQRYYSSLNNSIECAQDSSACGGSDKTVLYNFARGRTYILSLNYKF
The following text describes a protein:
Function:
Probable microtubule-associated peroxisomal protein required for chloroplast biogenesis and for the formation of the prolamellar body and prothylakoids in etioplasts. Not involved in peroxisomal metabolism, including mobilization of storage compounds during germination, fatty acid beta-oxydation or photorespiration.
Subcellular Localization:
Peroxisome. Note=Located at discrete small spots potentially associated with the surface of the peroxisome.
Sequence:
MVAAIPQGAAISNTDSKNPPPRDRQDKPQLTANNGGLQRRPRAAKNVPSRYLSPSPSHSTTTTTTTATSTSTSSSSSVILRSSKRYPSPLLSRTTNSASNLVYTPSSLPKRSQSVDRRRPSAVSDTRTEMSAATKMLITSTRSLSVSFQGEAFSFPISKKKETATPVSHRKCTPERRRATPVRDQRENSKPVDQQLWPGASRRGSSESVVPNSLSRSVDSDSDDGRKLGSGFVGRSMLQHSQSSRVSGDGRLNLGFVGGDGMLEMRDENKARQSTHPRLASSVSCDFTASDTDSVSSGSTNGAHECGSGEVSKTRSLPRNGMASTKFWQETNSRLRRMQDPGSPQCSSPSSRISSISSKFSQSKRFSSDSPLTSSPRGMTSPIRGATRPASPSKLWATATSAPARTSSSPSRVRNGVSEQMNAYNRTLPSILCFSADIRRGKIGEDRVMDAHLLRLLYNRDLQWRFANARADSTLMVQRLSAEKILWNAWVSISELRHSVTLKRIKLLLMRQKLKLASILKEQMCYLEEWSLLDRNHSNSLSGATEALKASTLRLPVSGKAVVDIQDLKHAVSSAVDVMHAMVSSIFSLTSKVEEMNSVMAEMVNITGKEEVLLEQCQGFLTRVAAMQVTDCSMKTHIIQLSRL
The following text describes a protein:
Function:
Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Sequence:
MQQNIIKIKVGSKNPVKINAATKAMAQLFPDSIIDASGMDAPSGVAAQPMTDKDTRQGAINRVHYCQQQDQQDTQADYYFAMEGGVDCFDFGPATFAYIAIGHKDQLAIGRSAILPLPMQVYRALEAGEELGHVMDRLFNTVNIKQKGGAIGLLTHGHATRESNYTQAIILAMAPLLNPDIYAQTC
The following text describes a protein:
Function:
Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.
Sequence:
MALFNSAHGGNIREAATVLGISPDQLLDFSANINPLGMPVSVKRALIDNLDCIERYPDADYFHLHQALARHHQVPASWILAGNGETESIFTVASGLKPRRAMIVTPGFAEYGRALAQSGCEIRRWSLREADGWQLTDAILEALTPDLDCLFLCTPNNPTGLLPERPLLQAIADRCKSLNINLILDEAFIDFIPHETGFIPALKDNPHIWVLRSLTKFYAIPGLRLGYLVNSDDAAMARMRRQQMPWSVNALAALAGEVALQDSAWQQATWHWLREEGARFYQALCQLPLLTVYPGRANYLLLRCEREDIDLQRRLLTQRILIRSCANYPGLDSRYYRVAIRSAAQNERLLAALRNVLTGIAPAD