lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.
Sequence:
MVKPLRLNDRHQQILRATVQHYIATAEPVGSHTLAQEYQFAVSSATIRNALGQLEKAGLLYQPHVSAGRVPSDSGYRIYVDNLLTWSDRQSRTVKQRLENEINGDNWHFEALIQRMGQILAGLSGYIALITFPQTETVQLRHLQLMLLPSHQILIILVTDSYHTHSATLDLPAAMEAKEEGELEQELAIFSNFLNAQLRGKNLSELSHLNWQELDQKFSIYADFLKGLQQQIKPLLQRRMAGPLVVHGVSKVIQQPEFSQLEQVQMLLSLLEQEQDKLFSLLFDPDNYGDNLANLGQEMNLLTGETMPKTRPVVTIRIGAENPLESMHPCTLVSAIYRQQEIPMGSVSILGPTRMVYQQTIPLVEQAAECLSEALSKN
The following text describes a protein:
Function:
Involved in the biosynthesis of the anthracycline (aromatic polyketide) antibiotic nogalamycin. Catalyzes the oxygenation of 12-deoxy-nogalonic acid at position 12 to yield nogalonic acid.
Sequence:
MPTRVNDGVDADEVTFVNRFTVHGGPAEFESVFARTAAFFARQPGFVRHTLLRERDKDNSYVNIAVWTDHDAFRRALAQPGFLPHATALRALSTSEHGLFTARQTLPEGGDTTGSGHR
The following text describes a protein:
Function:
Probable inactive glycosyltransferase.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Domain:
There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding; The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
Sequence:
MEVFASVLNCCFKYIVLPVWIFIVLLLLHRDLSSWDGLMGPLSHPGLGENGSASYLSVPSWEIDEYTQGWRYYLYNSWLAERIPLRRSLPDLRDHRCQKLEYDEDSDEMKPASIIMIFRNEQLVVLLRTLHSLVERTPKYLYIELILVNDHSDTDFWNDKLSLIFFDNYVHRYIHPKARILHLPEQVGLIKARNLAASEAKAENLVFVDAQVEFTNGWLSPLLDTIAEQSYTLATPILDNLDEQTLAYQRSIERRGMYDWSLTRREVPLSRARRSHLPWPYEVAAVRTSVFAIPAVWFQDISNFDNNLRGFGAAELELSFKVWCTGGRIVQVPCSRVGHLQPKDEDYLKRYGDLHKMGEQKSRNLKRIIEVWTGDLKSAIYKYQPHLLNISEGDLNEPRKLYKQNECQSFKEFINDITPGLNHVAALNRTDYASGHVKTLEFPKKCLTINAKSQNLFLERCSTNNTLQNWTLTYVKDLRVAGNICAEVRPNLRLGYSFCHSLGGRQSWHYDSVSNQLMSNTKCLEFTDELNIFLAICDAANGKQRWILDNINLSVMQSANILV
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MEDCEGAQHDTEPDVEEDDALRLVREEVQTSRGVGKWTLKLLQEFFNKDSEPLESDSDANATKKKGTRTKRYLPQKNSAPFALLITLYRESLNGRSSMKKQELIDATEASGLTHMPIGLPNSSGKGGGFGGLARDWYCGWNSMKTLLTKGLVVKSSCPAKYMLSQEGQETARECLQRSGLRDCDIPLAKKPDKSGANGEEMLVSDINKKLSKRKSVSASLELSEMMTSMEYSDKDAHLTSSEASQMVGDKDVSSLRTCTFGHHLKMRVDALLAEPTQKISIEIHDLSDASDSGDTGPVSLLSKRTQPRCSNESSLGTSGLRACTSSAVVGDAQGSCGNALAVPPCSPGEKFEDLYDALTVELIIWLGWVPFSLLEVNLPFLLSSTLKG
The following text describes a protein:
Function:
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Subcellular Localization:
Cytoplasm.
Sequence:
MTDEDYPTDDPAVVTCGLPYPTGDLHIGHLRTYVSGDAFSRALRKLGQETVFVSGTDMHGTPIAVQAIEAGVGPLDLGLERHEQYADTFEEFSVAFDTYGHTDEETNVELTREFVGAWEDNDHVYETEIQVAYDPDADQWLPDRYVEGTCPYCGEHARGDECDEGCQRHLEPGEIEAPVSTITGNSAEYHERAHKFLRLSDFQEYLEGFINRMEGTNNAKNQPREWIEGGLEDFCITRDLDWGIDYPGEGGDDLVLYVWVDAPIEYVAATKQYSERVGTEEFDWASVWKDGDGEIIHVIGRDIIQHHTVFWPSMLAGADYAEPRAVCATGFVNIDGRGLSTSKNRAIWAAEYLDAGFHPDLLRYYLATASGFERDVNFSWAEFAQRVNTELADAVGNFAYRALLFANRNFDGTPQEVSLTDDVETEIAQAMDDYEDALNEYDLRTAGERAVALARFGNEYIQHNEPWNLDSEAAAPVMRDCVQLVKAVAVLLQPFLPEKTETLWAQLGEDGRVSDATIADCLQAPPAEFGEPAELFEKIEDDRVTELDEALAAKIEAASSEDADGEGMADETADDGIELEPLAEDDISFEEFQALDLRVGEVVEAEGIEGADDLARLEVDIGHEVRQIVAGIKQLHDLDALPGTRVVVVANMEPSELFGVESNGMVLAAGEDADLLTTHEDSEPGTKVM
The following text describes a protein:
Function:
Part of the AP-3 complex, an adaptor-related complex which is essential for the compartmentalization of the endocytic pathway.
Subcellular Localization:
Endosome membrane.
Sequence:
MDTVLNNINQSRYFNDSTANTKIEEIKKHLDSPSDADKLESMKKLIAMLSKGRDVSEAFPQVVKNVIVKNLEIKKLVYMYLVHYAESQNDSALLSINTIQKSLNDQSQVIRASALRVMSSIRVIDIIEVIILAIEKSVKDTSPFVRKAAAFAIAKVHKLDCDKQEPLIDLLEILLNDTSTMVLGAAIVAFNELCPQRFDLLHQHYRKICQLLADFDEWSQVIVLDILTKYARSQFRCPDSTMNDKNIKQFKKKSKSFYSDEEDQEDDEPENSLYKKKPLERDMFDSSEEIDMDHRLLLKSTLPLLQSRNNAVVMAVSSLYFYCAPSIEAQKVGKSLVRILRSGPEVQYITLTNISTMVTLRPSMFEPHLSEFFIHSSDPEYSIKLKLEILTRLATPENIGKILKEFKEYVKNEDKKFVAATIQAIGSCASTVPDVTESCIYGLMSLLSNQSTVVVAESVIVLKRLLQLNATNEKLEKLEKEKEKEKDVKENQSTISKHSSSNNSIKYDNIILHLSKLLDTLQVPSARASIVWVIGEYCYRVPLVAPDVFRKLVKSFSDEHESVKLETLNLGSKLYVQFTDNNSTTTTDNSIPNEFKNERTKEKITLMFQYVLNLAKFDQNYDIRDNSRMLKHFYFNTENTQSINSNIKQIVINQKPIPTETSISEDRQRFTLGSLSHIVNHTALGYTALPDFPDVAPDPSVREPIQRWIPNQQSQQQQHQQQQLNNIFVDTPFYSDEEEEDEEEYDEEEEEEEYEEQNEYEDFFGEEKKNKKKNRKQQNYDEDEYNQDIDDGEYDGEGEVQAEDEDDFDELFGITNDDNNQTANGIGGGGSGEEEMDKFDFENYINSTTKSVKKILLKPTISGGLSIDYCFIRIRDNEEFSCQPRYNIIQLNIKNQSDETFTDISIINKNLIDGADISEFDPIESIEPNQAIQKQIYVLFNSTSQSCKFEISFNKGNFPVTLTPIIGELLIPIVPIYESISQWKDEFEEVGEFKQVDDQFEFGDQCLDKLNNNNNNNNNNNNESGDENIGLMPILPIVLEGINLIPIASNKLKSKIQFASKTLLKDENIYVQIQLLKQQPPTVNCIIRSNDQVVSALLLKKLKDVLQK
The following text describes a protein:
Function:
Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Also has chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MQLLPEGQLRLCVFQPVHLTSGLLILFILKSISSLKPARLPVYQRKPFIAAWNAPTDLCLIKYNLTLNLKVFQMVGSPRLKDRGQNVVIFYANRLGYYPWYTSEGVPINGGLPQNTSLQVHLKKAAQDINYYIPSENFSGLAVIDWEYWRPQWARNWNTKDIYRQKSRTLISDMKENISAADIEYSAKATFEKSAKAFMEETIKLGSKSRPKGLWGYYLYPDCHNYNVYATNYTGSCPEEEVLRNNDLSWLWNSSTALYPAVSIRKSFADSENTLHFSRFRVRESLRISTMTSQDYALPVFVYTQLGYKEEPLLFLSKQDLISTIGESAALGAAGIVVWGDMNLTSSEENCTKVNRFVNSDFGSYIINVTRAAEVCSRHLCKNNGRCVRKTWKAAHYLHLNPASYHIEASEDGEFIVRGRASDTDLAVMAENFLCHCYEGYEGADCREMTEASGPSGLSLSSSSVITLCLLVLAGYQSIQL
The following text describes a protein:
Function:
Component of the MIM complex required for outer membrane protein import. Involved in import of the subset of proteins with multiple alpha-helical transmembrane segments, including UGO1, TOM20 and FZO1.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MADSEDTSVILQGIDTINSVEGLEEDGYLSDEDTSLSNELADAQRQWEESLQQLNKLLNWVLLPLLGKYIGRRMAKTLWSRFIEHFV
The following text describes a protein:
Function:
Member of the three-protein two-component system HK1/HK2/TcrA. HK2 transfers its phosphoryl group to TcrA.
Miscellaneous:
MISCELLANEOUS: HK1 and HK2 are merged into a single protein with a distinct N-terminal sequence in strain CDC 1551 / Oshkosh.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MALVLAAAGAVTVVQFRDAAHEADPDGALRGLTDDITADLVRELVTILPIVLVIAAVAAYLLSRAALRPVDRIRAAAQTLTTTPHPDTDAPLPVPPTDDEIAWLATTLNTMLTRLQRALAHEQQFVADASHELRTPLALLTTELELRCAGPDPPTS
The following text describes a protein:
Function:
Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton.
Sequence:
MSAKRDETDFDKSPAYDYEDDFEKDLDWLINEDSQANADLKIKQEENGHEISEKEPEAFNANPRYELTGKDEAEAENQTNDSEDEEARRYIAEKIEEANKLLQNQIIYEKRERKLKFKDNLVDLEVPPVEYHENERNDDEDIVDSFSQLHVSNAAWMNEHHDDNGRIDEQKDGKILIEKDGKFELVTLSDIESLSFFPPINNSSSEKDMQKPLLTAQQQSTIGNEGFVGQKGINGYNDVYLPQPPTTPKARPSSAAYFIKSSHRMNSPRRVKSAGLQSRNTTFCLSPEQKEIQKTINERQMKQKKEEEEHKKEEEEQKRKENEIAFKAWILKKKYQLAGERRIQQTKQLEGMSVTEEEEERDPQKAFNLWLKRKHKETLRERKIDDLKKPEERGEGEKAFKRWLKEKRIQKRTEHQAALERSRRLLLDAKRKKQIQTLLYRISDSRSFGYVDNCR
The following text describes a protein:
Function:
Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection. Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11.
Subcellular Localization:
Cytoplasm.
Sequence:
MAEYELMHIHSLAEHYLQYVLQVPAFESAPSQAFRVLQRVAFSVQKEVGKNLKSYLDDFHVESIDTTRIIFNQVMEKEFENGIINWGRIVTIFAFGGVLLKKTSTRADCPGCTCLQTSFQFWGRIHHE
The following text describes a protein:
Function:
Involved in the catabolism of quinolinic acid (QA).
Sequence:
MILKIEDLVMSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGYNHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGADIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
The following text describes a protein:
Function:
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Sequence:
MFPNFFLTLELEEEAQAARPIPRLPWAGASLPHQTALHIAVIVNQPECVRGLLCVGASPDLQERSGNTALHIACREGLRECVRELVSHSLSRAPLHTTNYAGVTPLHIAVQKVDEGAVRLLLHAGADANRRDLSSGRTALHWAVESQSAALVRLLLSRGAAVDAPSYAGHTPLYCALHRPSEAVRSLLREGGAVEPLEEDEEEEDDEEEDDEEEVDELERKEVRENEEEWDTINSSNL
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
Sequence:
MELVQPFSGFLVYDLKQTPEDFQVEEILPSDLIQKTGKWMIFRLQKSGWNTLDALLRISKESKVSIFEIGYAGKKDRHASTSQYISCQKPLRVPKELTKVIQLDKIGFSKKSLSTELNVGNRFQLVLRNLLEKEIESIRNNFEKITKNGFINYYDSQRFSRFHSEFRLPILPFFKGDAETCLKLILTDPFPGEKKQARDRKKILYDLWGNWSQCEKWSKSKLEKNIFSNLKKEKKPTQKTYSDLILRFPEEELLMLVSSFQSLIWNEFVSEIFISDNFTGVWIKTKTGPLFFPGESSIQSVPFSKNLPVPGNPGIYKLEYSKKEIDTLKKILNQNGLTESVLDSSPFPIIKMNSFERKVRILPNDFQIGDFEEDDQHPGKRKVKISFRLPSGVYATMLIKRLMLRSRI
The following text describes a protein:
Function:
Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate.
Sequence:
MSKAGASLATCYGPVSADVMAKAENIRLLILDVDGVLSDGLIYMGNNGEELKAFNVRDGYGIRCALTSDIEVAIITGRKAKLVEDRCATLGITHLYQGQSNKLIAFSDLLEKLAIAPENVAYVGDDLIDWPVMEKVGLSVAVADAHPLLIPRADYVTRIAGGRGAVREVCDLLLLAQGKLDEAKGQSI
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MEMCERNSLNPGYVGSLLNFAPPESLYFTNLRGNGTHIPALHQLQYNRRDVCTLPWTPSSSCSGPAVPPAQSRAFEGYCPPFLSSALSANAGSSKTHVDECAARCFRDLKTEEAGVHEELYISEHGVRAYSDLDSGHRSAGQPDPDSESPHDVNGTKQEQDPPSSHDACSRTTFGQGTPWCSSQVRSRKKRKPYSKPQLAELENEFLMNEFINRQKRKELSDKLDLSDQQVKIWFQNRRMKKKRLMMREQAFSAYC
The following text describes a protein:
Function:
Probable glycylase which modifies tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of tubulin.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Note=Mainly present in locomotory and oral cilia.
Sequence:
MILPFEYYFLNDADNSSKSNYNNIQFINENQNNNLRQKPKFYPNNQFLIEQEQDKYENKKIKNYISDQIQLQPKNTPINKMNHFANINNYQDNKFSLESLNQAQQDNLQKEEDLSILSFDSQEELNYLQEGEENNQFLNEGDIFGYQTRYTFFENRNNLLVEDATNKNNNNYNYNYNNNNSSTQRNYDFNYQNTNEMLQKKKKSNFQNKSQSQLNNHKNEEKKPSQQRKEQLMKRFESLSRIYNKELSQTVTNGWLKPSQAKTISQDNNLGSSAAKSSKVFYQQQKPFSAQITNSSLKYAAASNGFQNLDFSYKQKQQLIQQETKNKIKEQQNVESNNRISMKPPKSANLNSYKNISNLKNFKEIILTRPNSKQVKFQQQNSVNSQPSSLVSQPLKIQSIEKNNLNSNLNDQNFYDDFAELGSTETTGFSFQNVFQLAGVPKDFIASPRSPVQELNQKQENRENELDQMLNDHHIYVASSVTNQNQIKNEQTERKPNMFGKTLTTLARPFSKEYSNRKDILKSAQQNVRFNKNLDYLDSQNKVVAKNKKRTIFKINQNNLQGNQKDLQSNQTSSVISQQNSIQQYGDDNYQQNQVLNDDQSPLIKQNSIDLNAAEIIQNDENENTQKENVLQQKKNQSNQIVTSQQQSNNYFKQETTTNTSNFSTTSNRIISLQALRQKNNSTVKNSDNNNQNQTNPQNQNTNLKENNDKQNLKKTKIQSASANQAGQSNNQLQKTFFINSQDEYVRRTLLRMGWKENKLLLNNNFDLKWIYIDSNDDYKFLNDNQFYNHFKNNTELTQKGRLLYNLKNNTQFGVNQELFFPRCYDLGNDQERGEFSNEFNRMNVMNLLKKHIQYIKLRRSQTYQEIKQAYQQKQANKLNAQVKDGIFFAKVTKQKFFSPLMYEDTKRDNRFIFNITVIAEAVEILKKLKRQQEEYIDETRQSRDCQLYIYQTNFKLESMISQYVKINVPFDEEKFVFEKIVGMSKEHWSSPSMKLMKKLYSLYKYFKDADPQFKVSGTKNIWIIKPSANSRGSGIYLVDKLDEAIDSGLKMQARIVQKYIERPLIFQGAKYKKLNNKKFDIRQWVLVTSFKPLKIYFFTSSYLRVCSQSFDLDNIKILSKHLTNFSLNKNSLAKENWDETVVELKDFISYLKEFKNIDYQEDVKPKIKDLVIETIKCAADKIVNRKKSFELYGFDILLDEYAHPWLLEVNLSPACSERSSFLTEMLDAMAYKMFQIVFKQNNLQEDLEINKETAISTAPASCQNPDYDWEEIYNEEQKEYFCEEDNNMQLAFNNDIQLMVIGQKADLKKEKNLDKKYFQYWGAIKIQSKIRSFLAKKKLQRLKNQKFTFAAIKIQQKMRQFLAKKQLNILKKQQQTNINIPIEDFNQVSVIEV
The following text describes a protein:
Function:
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments. Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MVAEVGSMPAASSVKKPFGFRRKMGKWGCHCLPCCRGSGKSNLGASADQDDSARKTRRSKMAKWCCHCLPCCRGSRKSNVGASGEQDDSAMKTLRSKMAKWCCHCLPCLRSSKSNVGAWEEYDDSAFMEPRYHVRREDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKTDKQKRTALHLASANGNSEVVKLLLDRQCQLNVLDNKNRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTALHYAIYNEDKLMAKALLLHGAAIESKNKHDLTPLLLGVHEQKQQVVKFLIKKKANLNAFDRYGRTALILAVCCGSASLVSLLLEQNIDVSSQDLSGQTAREYAVSSHHNNLRQEKVLYEPSPSRDSQICQLFSDYKEKRMLKISSENSNPEQDLKLTSEEESQRLKGSENSQPEKMSEEPEINKDCDREVEEEVKKHRSNHVGLPENLTDGAAAGNGDDGLIPQRKSRTPESQQFPDTENEECHSDEQNDTQKQVSEERNTGISQDEILTNKQEQIEVTEKKMNSELSPCPKKEKDLLHENSTLQEEIAMLRLELDMMKHQSQLREEKYLEEIESVKKENDDLLKAMQLNELTMDDDTAVLVIDNGSGMCKAGFAGNDAPRAVFPSIVGRPRHQGIMGGMGQKESYVGNEAQSKRGILTLKYPMEHGIITNWGDMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAALSLYTSGRTTGIVMDSGDGVTHSVPIYEGNALPHATLRVDLAGRNLTDHLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKSDVDIRKDLYSNTVLSGGTTMYPGMADRMQKEITALAPSTIKIKIIAPPERKYSVWVGGSILASLSTFRQMWITKQEYDESGPSIVHRKCF
The following text describes a protein:
Function:
Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.
Subcellular Localization:
Membrane. Synapse, synaptosome. Cytoplasm.
Sequence:
MTTLDHVIATHQSEWVSFNEEPPFPAHSQGGTEEHLPGLSSSPDQSESSSGENHVVDGGSQDHSHSEQDDSSEKMGLISEAASPPGSPEQPPPDLASAISSWVQFEDDTPWASTSPPHQETAETALPLTIPCWTCPSFDSLGRCPLTSESSWTTHSEDTSSPSFGCSYTDLQLINAEEQTSGQASGADSTDNSSSLQEDEEVEMEAISWQASSPAMNGHPAPPMTSARFPSWVTFDDNEVSCPLAPITSPLKPNTPLSASVIPDVPYNSMGSFKKRDRPKSTLMNFSKVQKLDISSLNRTPSVAEAPPWRATNPFLNETLQDVQPSPINPFSAFFEEQERRSQNSSISSTTGKSQRDSLIVIYQDAISFDDSSKTQSHSDAVEKLKQLQIDDPDHFGSATLPDDDPIAWIELDAHPPGSAWSQPRDGWPMMLRIPEKKNIMSSRHWGPIYVKLTDAGYLQLYYEQGLEKPFREFKLEICHEISEPRLQNYDENGRIHSLRIDRVTYKEKKKYQPKPAVAHTAEREQVIKLGTTNYDDFLSFIHAVQDRLMDLPVLSMDLSTVGLNYLEEEITVDVRDEFSGTVSKGDNQILQHHVLTRIHILSFLSGLAECRLGLNDVLVKGNEIVLRQDIMPTTTTKWIKLHECRFHGCVDEDVFHNSRVILFNPLDACRFELMRFRTVFAEKTLPFTLRTAASVNGAEVEVQSWLRMSTGFSSNRDPLTQVPCENVMIRYPVPSEWVKNFRRESVLGEKSLKAKVNRGASFGSTSVSGSEPVMRVTLGTAKYEHAFNSIVWRINRLPDKNSASGHPHCFFCHLELGSDREVPSRFANRVNVEFSMPTTSASKASVRSISVEDKTDVRKWVNYSAHYSYQTTETDNLPNPLFCSCLPHTDLKRGSKRVVKIRWNASLEVPPASSIRTMV
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm.
Sequence:
MKVYINVYDLMPDSPVNKLAWTLGLGIYHTGLVLEGKEYAFGAHEIPGSTGVFATMPRPPLEGCRWRCSIALPNCTLPKPDVDRILIRLSQEFTGLSYSLLERNCNHFTNAAAIELTGSPIPSFLNRISRIGLAFPTITNALLQHGQKNTSDVDDSSDSSSDVDEETLIVSKSKKAHKDIPKFSAPPPSADLNNLITDSLP
The following text describes a protein:
Function:
Freestanding tRNA editing subunit of threonine--tRNA ligase, the catalytic subunit is probably AC Q9YDW0. Deacylates (edits) mischarged L-seryl-tRNA(Thr) in trans; has no activity on correctly charged L-threonyl-tRNA(Thr). Probably does not aminoacylate tRNA(Thr) (By similarity). Deacylates correctly charged glycyl-tRNA(Gly), but not glycyl-tRNA(Gly)(2'-dA76) (the terminal 2'-OH of tRNA adenine 76 has been dehydroxylated) nor the 2'-fluoro tRNA derivative, strongly suggesting the editing function is catalyzed by the 2'-OH of A76 of tRNA(Thr).
Miscellaneous:
MISCELLANEOUS: There are two ThrRS in this archaeon. The first one (APE_0809.1, AC Q9YDW0) is most similar to bacterial ThrRS but it lacks the N-terminal editing domain. The second one (APE_0117.1, this entry) is most similar to archaeal ThrRS but lacks the central catalytic domain; it probably does not aminoacylate tRNA(Thr).
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal domain (about residues 1-140) is an archaea-specific tRNA-editing domain that has a highly similar structure to Dtd (D-aminoacyl-tRNA deacylase). Editing of incorrectly charged L-seryl-tRNA(Thr) by this domain is tRNA catalyzed.
Sequence:
MRLLYLHADRFEYKTVKPALKNPPDPPGEASFGEALVVFTTVEDGDGPQTVMYAASDIASHSSRLKVTTVILYPYAHLSSRLAKPMAAHKRLIELEGALRTKFPGHVHRAPFGWYKSFSIACKGHPLAELSRSFTEAGALQPWPAVEDYKTGLSGEVLARAGLLGGGSLSPASWALEVHRRLAEEVVGPAESVGFGESLSEAYQACISSSVTTLLMGPYPPSIVFGPLEDDPVEAVSRVLGLISPQLEGVKPLLSGGEGALKASSPDGAELPVAFLKEGRVCLGPTLSFFKLAVSMLVEKARKEGLTPYLNPTLTPVQSAVIPVDSESEGYAQRIAEDLAASGVRVSIVRGSGLGRRVREAGRSWASLVIVVGKREEETGTVVVRRRWEPGKQEVLTLDELSSEAKKLASGSRGSLYSTTL
The following text describes a protein:
Function:
Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution.
Miscellaneous:
MISCELLANEOUS: This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein precursors. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries; MISCELLANEOUS: Has a type 1 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene. Type 1 genomes lack a pol stop codon, leading to expression of a fusion protein containing a portion of the Env sequence; MISCELLANEOUS: Exact N-terminus of this protein has not been formally described.
Domain:
The LPQG and YXDD motifs are catalytically important and conserved among many retroviruses.
Sequence:
NKSRKRRNRLSFLGAATVEPPKPIPLTWKTEKPVWVNQWPLPKQKLEALHLLANEQLEKGHIEPSFSPWNSPVFVIQKKSGKWRMLTDLRAVNAVIQPMGPLQPGLPSPAMIPKDWPLIIIDLKDCFFTIPLAEQDCEKFAFTIPAINNKEPATRFQWKVLPQGMLNSPTICQTFVGRALQPVREKFSDCYIIHYIDDILCAAETRDKLIDCYTFLQAEVANAGLAIASDKIQTSTPFHYLGMQIENRKIKQQKIEIRKDTLKTLNDFQKLLGDINWIRPTLGIPTYAMSNLFSILRGDSDLNSKRILTPEATKEIKLVEEKIQSAQINRIDPLAPLQLLIFATAHSPTGIIIQNTDLVEWSFLPHSTVKTFTLYLDQIATLIGQTRLRIIKLCGNDPDKIVVPLTKEQVRQAFINSGAWQIGLANFVGIIDNHYPKTKIFQFLKLTTWILPKITRREPLENALTVFTDGSSNGKAAYTGPKERVIKTPYQSAQRAELVAVITVLQDFDQPINIISDSAYVVQATRDVETALIKYSMDDQLNQLFNLLQQTVRKRNFPFYITHIRAHTNLPGPLTKANEQADLLVSSALIKAQELHALTHVNAAGLKNKFDVTWKQAKDIVQHCTQCQILHLPTQEAGVNPRGLCPNALWQMDVTHVPSFGRLSYVHVTVDTYSHFIWATCQTGESTSHVKKHLLSCFAVMGVPEKIKTDNGPGYCSKAFQKFLSQWKISHTTGIPYNSQGQAIVERTNRTLKTQLVKQKEGGDSKECTTPQMQLNLALYTLNFLNIYRNQTTTSAEQHLTGKKNSPHEGKLIWWKDNKNKTWEIGKVITWGRGFACVSPGENQLPVWIPTRHLKFYNEPIGDAKKRASTEMVTPVTWMDNPIEIYVNDSVWVPGPIDDRCPAKPEEEGMMINISIGYRYPPICLGRAPGCLMPAVQNWLVEVPTVSPISRFTYHMVSGMSLRPRVNYLQDFSYQRSLKFRPKGKPCPKEIPKESKNTEVLVWEECVANSAVILQNNEFGTIIDWAPRGQFYHNCSGQTQSCPSAQVSPAVDSDLTESLDKHKHKKLQSFYPWEWGEKGISTPRPKIVSPVSGPEHPELWRLTVASHHIRIWSGNQTLETRDCKPFYTIDLNSSLTVPLQSCVKPPYMLVVGNIVIKPDSQTITCENCRLLTCIDSTFNWQHRILLVRAREGVWIPVSMDRPWEASPSVHILTEVLKGVLNRSKRFIFTLIAVIMGLIAVTATAAVAGVALHSSVQSVNFVNDWQKNSTRLWNSQSSIDQKLANQINDLRQTVIWMGDRLMSLEHRFQLQCDWNTSDFCITPQIYNESEHHWDMVRRHLQGREDNLTLDISKLKEQIFEASKAHLNLVPGTEAIAGVADGLANLNPVTWVKTIGSTTIINLILILVCLFCLLLVCRCTQQLRRDSDHRERAMMTMAVLSKRKGGNVGKSKRDQIVTVSV
The following text describes a protein:
Function:
Secreted thaumatin-like protein that, with cetA, plays an essential role in early conidial germination with a possible role in cell wall remodeling.
Subcellular Localization:
Secreted. Secreted, extracellular space, extracellular matrix. Secreted, cell wall. Note=Present in the cell walls of the germinating conidia but not in the germtubes.
Sequence:
MLFNKIISLAATLATASALPFAPAPRSISGGVTLINNLSQDLYLWSVSGTASPMVTLPAGQSYQETWQINPTGGGISIKIGCSEDGSDVLQYEYTKVGDLLFWDMSSIDLSSGSPLVAAGFDVSIDDSSCDTVTCAPGDVNCSESYQYPDDHNTRACSSSAAYTLTLGTAN
The following text describes a protein:
Function:
Microtubule-severing enzyme that negatively regulates cell migration and wound healing. In migrating cells, targets dynamic microtubules (MTs) at the leading edge and severs them, thereby suppressing motility. Microtubule severing releases ARHGEF2 which activates RHOA, which in turn regulates focal ahesion turnover via focal adhesion kinase, as opposed to F-actin polymerization, to suppress cell motility. Negative regulator of axon regeneration that suppresses axonal growth by selectively severing dynamic MTs in the distal axon shaft and growth cone. Contributes to proper cell branching during endothelial and neuronal development.
Subcellular Localization:
Cytoplasm, cell cortex.
Sequence:
MHWTPEHAQPLNQWPEQHLDVSSTTPSPAHKLELPPGGRQRCHYAWAHDDISALTASNLLKRYAEKYSGVLDSPYERPALGGYSDASFLNGAKGDPEPWPGPEPPYPLASLHEGLPGTKSGGGGGSGALGGSPVLAGNLPEPLYAGNACGGPSAAPEYAAGYGGGYLAPGYCAQTGAALPPPPPAALLQPPTAAPGAESGLSLKRKAADEGPEGSYRKYAYEPAKAPAADGASYPAADNGECRGNGFRAKPPGAAEEASGKYGGGVPLKVLGSPVYGPQLEPFEKFPERAPAPRGGFAVPSGEPPKGVDPGALELVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPGSLRRPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLIISELEALLPARDDGAAAGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRRRFSLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQAAAGAGLPGLQRPLSYKDLEAALAKVGPRASAKELDSFVEWDKMYGSGH