lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Converts 2-oxo acids to branched-chain amino acids. Shows activity with L-Leu, L-Ile and L-Val as amino donors and alpha-keto-glutarate as an amino acceptor, but no activity for D-isomers of Leu, Ile, Val, Asp, Glu or Ala. Acts on methionine and its derivatives and the corresponding 2-oxo acids. Catalyzes the initial deamination of methionine to 4-methylthio-2-oxobutyrate as well as the transamination of other typical intermediates of the methionine chain elongation pathway.
Miscellaneous:
MISCELLANEOUS: Although all the other members of the family possess a branched-chain amino acid aminotransferase activity, the exact function of BCAT4 remains unclear at present.
Subcellular Localization:
Cytoplasm.
Sequence:
MAPSAQPLPVSVSDEKYANVKWEELAFKFVRTDYMYVAKCNHGESFQEGKILPFADLQLNPCAAVLQYGQGLYEGLKAYRTEDGRILLFRPDQNGLRLQAGADRLYMPYPSVDQFVSAIKQVALANKKWIPPPGKGTLYIRPILFGSGPILGSFPIPETTFTAFACPVGRYHKDNSGLNLKIEDQFRRAFPSGTGGVKSITNYCPVWIPLAEAKKQGFSDILFLDAATGKNIEELFAANVFMLKGNVVSTPTIAGTILPGVTRNCVMELCRDFGYQVEERTIPLVDFLDADEAFCTGTASIVTSIASVTFKDKKTGFKTGEETLAAKLYETLSDIQTGRVEDTKGWTVEIDRQG
The following text describes a protein:
Function:
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
Sequence:
MIFMEIETFLKKSLKNKIDFDDALYLYNNFSAIDLLYLAFKIKNRIKNNSKIKLCAIINAKSGKCKEDCIFCSQSIYSKCNIPIYPLKSKKEILEYAKKIIDECSKISSSIERGTLIGAESPNLMDVGYPNRGFPLWVERFSIVTSGKKINDDEFIEIVEAIELIKEETNLKVCCSLGLLDREKLKELKKLDVRIHNNLEASKNYFKNICSTHSYEDKVKVIKEAKKLDLEVCSGGIFGLGESVEERIKMAFELKELGVDSVPINILHPIEGTKAYEKIKNGEIKPISVSDALKLIALYKIIMPYAEIRLAGGRIYNLRDFQSYALMVLDGLMVGNYLTTKGRCLEDDLKMIADFHSL
The following text describes a protein:
Function:
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPFVQRVVQPVNVAQATAASLGHASGRFHCTPGKCRNNNCINKQSPDVEVPNGHGSPTSLTRVLVHQAPEDQPVPPAPAPMKKLKHHVEFLSTSPTRHQSQSLPNSRHPSQQRPALGRIASAPQSPTAGSSKVVSGHEFDSISNITLSNALRQLASLVLIASDIFDDLQRDLQAVGERAGRVQRKIAAVERRVCAYDPKTVTVPESDLLTFAQRKHHFETDKSFQQELFTGETRPLSVRQLYTEAGKELPVATGATATALASLAHSQSLIPSRSISFNGEVLSSDHEVLQLNGSTDTEDHLLCVSDFGNANRKLRTRIDAEIEIRLPAAIEDLRKWTSSEALGDVTVTPDCMHHVDTSVSTSLAIGENGILTPALSPSVLSADAVDALYAQNLSQAADSSRHNHHTQALIPNDINKDVPLNHRLPSPEEQTKQIALKYPAEVISVNTSGKHFQRMCAARKSTSGGYAGGATAGSSSSTSPENAGQTEGNNLDDNVQTVSRRSRSRKVRGKRRNTIAGIDQKEIQDAANGNGESKNASNATSPVAPAQQAETTSSDAKKSKKFGRSKSSDILKKESAALPYDKGKSTLTRLNSLKQWGRNRFKFMHRTGELGDQLDTSGCSSQNSSAEKADSHHGSPAGDNSKRDIDDECVVHHLVAQKSESRFSHERKPSYSSSEKSISVSSSGQLRGRLQLSSGPMAAAHVKMRETATLNRQRRNGLHALAGKEEQPHSSSGNWSASSESGRASIGSEITMQPKSSASSTSLNVSSFQPGGAGSGPPSSMLSRRRFLNTSASSSVTSEGTATPELQAEAGAYPGHLDDETSSAYSCDTEGYYTSFHMDSGLRTLKEEEPSVMPGTPLQTSLHTSSYSFGSQSNQTVLNAESEYELFGRGSTSTTTSSAGTVCTALMSGAASGPDVPERSSSLGKHSGQSRSQSTSASSSTLERSYSSSTIGSTLERTGTIKRNVKMSPTKAGGEVTEKDDQQDQDQQQQLEFSESSDLEGVERIERIKQKTALTSKRIPSMCIITPTTSDDDEHQTNDPNRTLTSLTIDVEHGEQDEDEAEQKTPTNSKDHNLNELKQTPTKALSGMFEKLRVKLVPGKSSPAKNQMQPKPANSSAVNDDELYDLAGEYVTIADISNNNNNNKNIGRRNTGMGIYYSNDIVSKRVEPSTSAVSEYVSLNELPQHLRRHAVSSRSAPAAESESCAQQQLPVEPAAATSQPPPLPLGGRTQGVGDGVPMYAEIGELSEEKPLASAANRRLRPNAEGKLVYDSDSLKRRKGAHTTFAPGPYVKETESALHSAESAAAAIASSQDPSAASGAISSTKSAKLLLLTSGGLISGNRKVANVRPIVAKSPLSRNVSEMATYQATSYQDQKQLLANRTNPFYETIAAPVANLMMPSPSGKSNSSTGSTATSSSSSASGQSGEEGYQRFSNIYEQVQPAPSTQPQEDATATPFQRSAPIYWTLQNRRSQPRPQPAGNVTCRDDLYATPIRRADRLPRPVAAAAATAAEGNRSNISPIVPRNRSGAFLTSTPTRSGEGERDSENTQLPPMKQPSRNWTDDAPERLNTCADRIGQSKTTLMDFKKLLLAKSAKASPVQRKVSAVELLKKPAQATATPPVVKPSGPGQKVASAGSKPTINTSLKLLDLSGSPKTFANRRMLRQGQFGSPSKTFAPKMRGPVNMVAAAAAPPRTDIMSTTIPEANSEEDHSNTSGGSRASSEAGETVPSSFDLKRNFFLQTEENNFMRGELKPSFARSNGAAGGGSTEGVNKYVAAPVANPPLPSFETAL
The following text describes a protein:
Function:
Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons. Also functions as an adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export.
Subcellular Localization:
Cytoplasm. Nucleus speckle.
Sequence:
MDSVCVSHAGGQMDSISGTMHRDSCPLDCKVYVGNLGNNGNKTELERAFGYYGPLRSVWVARNPPGFAFVEFEDPRDAADAVRELDGRTLCGCRVRVELSNGEKRSRNRGPPPSWNRRPRDDYRRKSSPPRRRSPRKRSFSRSRSRSLSRDRRRERSLSRERNHKPSRSFSRSRSRSRSNERK
The following text describes a protein:
Function:
Zinc finger transcription factor which acts as both a transcriptional activator and repressor. Binds to the promoters of genes that contain the 5'-CTTATCA-3' DNA consensus sequence in their regulatory region. Functions downstream of the Insulin/IGF-1-like signaling (IIS) mediated pathway. Involved in normal development, lifespan, stress response, lipid metabolism, innate immunity and exit from the developmentally arrested larval state known as dauer. Required for stress-induced expression of hsp-90 and resistance to heat stress, perhaps as part of a systemic stress signaling pathway. Involved in maintenance of proteostasis. Under hypoxic stress increases lipid levels by positively regulating fatty acid synthesis via fat-7 expression. Associates with homeobox protein ceh-60 at the promoters of some stress-responsive genes to regulate expression; may require phosphorylation for transcriptional repression activity. Acts downstream of nhr-14 to activate transcription of intestinal metal transporter smf-3, modulating innate immunity and iron uptake. May act downstream of the mTORC2 signaling mediated pathway. May act in a mutually exclusive manner with the FOXO transcription factor daf-16.
Subcellular Localization:
Chromosome. Nucleus. Cytoplasm. Note=Nuclear localization under normal conditions, cytoplasmic as a result of heat-stress. Nuclear localization declines over normal lifespan. Exposure to Gram-negative bacterium P.aeruginosa enhances nuclear localization. Hypoxic stress enhances nuclear localization.
Sequence:
MSFLNNDFGSPPATSSPPTTMPKLPTIQDMLNNIGASTVNLMQPNPYLMQNQIPLPVPNLPLNPFLHLNPAISQEIIQQFIAMSFNTPNVLASIANMGDDEGPSCNPKMRRGDLLKSVSMDSTEDPPSITLDNNGDMIVPNNDKEGWCRNKKYIEQTENGYMCTVCRKVYGRYNSVSYHVTIYHRNPPIKCNVPNCQFTTREARYIHFHKNYRHGIPLPESIDQGSRKCPHCRHVSKSPAMLEKHIRRHQIKDGLSNINEAIRERTSTICDEAMEIEPAETEVDPIETKPRSCTL
The following text describes a protein:
Function:
Monoglutamylase which modifies both tubulin and non-tubulin proteins, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins. Involved in the side-chain initiation step of the polyglutamylation reaction but not in the elongation step. Preferentially modifies beta-tail tubulin over the alpha-tubulin. Monoglutamylates nucleosome assembly proteins NAP1L1 and NAP1L4. Monoglutamylates nucleotidyltransferase CGAS, leading to inhibition of CGAS catalytic activity, thereby preventing antiviral defense function. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis.
Subcellular Localization:
Cytoplasm. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Located in cilia. In some cells, also found in basal bodies.
Domain:
The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding; Arg-722 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate-chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation.
Sequence:
MASAGTEHYSIGLRRGNSFKQRHPSGTVSASPSEKPSEVKVWSQAHQQVKPIWKLEKKHVGTLSAGLGTSFLGVPSQPAYFLCPSTLCSSGTTAVIAGHSNPCYLQSLPNLFSNTLLYRRTNVRQKPYQQLESFCLRSSPSEKRSFSLPQKGLPVSVTANKATSSTVFPMAQPMATSPTDPYLSLAAAGENPSRKSLASAISGKIASPLSYKPMLNNNSFMRPNSTKVPLSQATDGLKPVSSPKIQPVSWHHSGGTGDCVPQPGDHKVPQNIATVLDDVTAPITPSIPSTLNISTASVTSSQCSQSNFRMEAHPCGLDENPDSQSATKEVHFTEAVRKLAEKGLEKMPRQGYQFEQACFVNPSFQWGLLNRSRRWKPLMGQRFPQEDIGLDSAILPGTSDTLGLDSTVFCTKRISIHLLASHVHGLNPSPACGSAVDPQVLGEDRAPVPPSSLQPLGVAEVATRLSSVHLDQPGKEPEEAKDLNSCTKGGGSATDLQPNQVEPEDTEDELGDGLEDSCSHDENEEEEGDSECSSLSVVSPSESVALISRNCVDLMSKSLPNHEKVVRPALIYSLFPNVTPTIYFGTRDERVEKLPWEQRRLLRWKMSTVTPNIVKQTIGRSHFKISKRNDDWLGCWGHHMKSPGFRSIREHQKLNHFPGSFQIGRKDRLWRNLSRMQSRFGKKEFSFFPQSFILPQDSKLLRKAWESSSRQKWIVKPPASARGIGIQVIHKWSQLPKRRPLLVQRYLHKPYLISGSKFDLRIYVYVTSYDPLRIYLFSDGLVRFASCKYSPSMKSLSNKFMHLTNYSVNKKNTEYQANADETACQGHKWALKALWNYLSQKGINSDAIWEKIKDVVVKTIISSEPYVTNLLKLYVRRPYSCHELFGFDIMLDENLKPWVLEVNISPSLHSNSPLDISIKGQMIRDLLNLAGFVLPNMEDIISSSSSPSSSSGSSTSLPSSPRDKCQMTPEHFTAQKMKKAYYLTQKIPDQDFYASVLDVLTPDDVRVLVEMEDEFSRRGQFERIFPSRISSRYLRFFEQPRYFNILTTQWEQKYHGNKLKGVDLLRNWCYKGFHTGIVSDSAPLWSLPTSLMTTSKGDGTPNSASKSRKKSASEGTTLSSEDRSTPKSKKSQAGLSPISRKTLSSRSNENTSKQSKRSTPGLPVLKYSGQSSRLSAASASQSVTDSRLTAVSS
The following text describes a protein:
Function:
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
Sequence:
MYIRRLNDQTANQIAAGEVVERPASVVKELIENSIDAHASCIRVDILQGGAKQIRIQDDGDGIHPEDLVLALERHATSKIAKIDDLQDITTLGFRGEALASISAVSRLTLTSRQKNAEMGYRISNISHKIMTPVPAAHPQGTTIDVQDLFYNTPARRKFLRSPATEFQHIRRIIERLALSHFTTEFLLHHNEKEIIHFKSATTISGQENRIKSILGDVFMQSALAIEFSQSGLTLKGYIAEAAYTRSQPDLQYIYVNGRFVRDKLVAQALRQAYHDVLFHGRHPAYVLYLEIDPAFVDINVHPTKHEVRFRDPQWVRDFLIHAVKTALAQAKPGIVHPLPQSTAEYNPITNFAPTPLIEGQGNLSLIQEQPAPYTQTIVHKHPLGHALAQLQGIYILSQNEKGLVIVDMHAAHERILYEKMKKQLAEVGLAMQSLLVPINLSLNPQEITAWQTNKALFARLGFEIESFGPDKIVVRRHPSLLKPKNLENLIRDVLADLITHNTTSRVGERINAALATLACHAALRAPHYLTIEEMEALLREMEKTEHGGLCNHGRPTWKQFDIAELDTFFLRGQ
The following text describes a protein:
Function:
Histone methyltransferase.
Subcellular Localization:
Nucleus.
Sequence:
MIIKKSLKTVMPSLKRCRVSDSGADEDDFSGNNNRKKRKSSGGYYPLHLLGEVAAGIIPFNGYRIQTILAAGGDGGAAAAAAASWCTEVSRCAGEAEMNSPPKQRSNPVNEASRPPLVRTSRGRVQFDEAIDLSGTDAMVMQEGGRRAYRYGHGGFNSGDIVWAISGRHCPAWPAIVLDSETQAPQQVLNYRVAGTVCVMFFGYSGNGTQRDYAWIRRGMLFPFQEHVDRFQGQTDLNDSTPADLRSAIEEAFLAENGVVEMLMVEINAAAGNLDYLRSLPRGVFEACDSNQDQECNSPSQARFKGLLKKKELDSCDACGSRLSSKPSRKLNDSTLRSHRLCTACARLKKSKHYCGVCKKIRNPSDSGTWVRCDGCKVWVHAQCDKISSRNLKELSTSDYYCPECRARFNFELSDSENMNSKAKNNKNDTQTVALPDKVSVICSNVEGIYFPRLHLVVCKCGYCGAQKQALSEWERHTGSKIKNWKTSVRVKGSLLPLEQWMLQMAEYHAQNVVSTKSVKRPSLKVRRQKLLSFLQEKYEPVYAKWTTERCAVCRWVEDWDYNKIIICIRCQIAVHQECYGARNVRDFTSWVCRSCETPEIERECCLCPVKGGALKPTDIQQLWVHITCAWFQPEVCFASDEKMEPAVGILRIPSNSFVKICVICKQIHGSCTQCCKCSTYYHAMCASRAGYRMELHCSEKNGKQVTRMVSYCAYHRAPNPDTVLIIQTPKGVFSARSLLQNNKRTGSRLISTSRLKLEEAPAAEIEEIEPFSAAKCRVYNRLRDKGTGETAIAHHVRGPCHHSSSSMRSLSIIREVRGSKTFSTFRERLRELQRTENDRVCFGRSGIHRWGLFARRNIPEGEMVLEYRGEQVRRSVADLREARYRVEGKDCYLFKISEEVVVDATDKGNIARLINHSCMPNCYARIMSVGADESRIVLIAKANVAAGDELTYDYLFDPDECEDFKVPCLCKAPNCRKFMN
The following text describes a protein:
Function:
Stimulates the phosphotransfer from phospho-DegS to DegU. Affects protease and levansucrose production.
Sequence:
MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMKIS
The following text describes a protein:
Function:
Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.
Sequence:
MMNISPQFKRWGQNTRNLQQQEAYPLREPPFDTYMVLDFEATCERHQRLEVPEVIEFPIVLVDARNGNTISEFQQYVRPVVNPQLSQFCTELTGITQSVVDRASTFPDVFTAAMNYLHQNNCGEREINKRYLPVTCGDWDLKTMLPIQVKACIQQGFTVNVPPSLRRWFNIKQYMQRVLSPGLGQTVSQPIRDLPDMMSVLGLEMKGRHHSGIDDCRNIAAVLCELIKLGHVITPTTDYNSELTRGTSWVSVGATTSLKPSAGLGKCQQMPHCREEGSNNSAMGRKRAASDTVNNQQSMIKRIHINVLENEDPLQDLLNLKTDDRNRMGSEDMTKEKVVTYSKALSRILRHGADKMKITISDAGYVLADDLVRCAPFSNDKAALTHLAWVVYSNDKKRFKMAYDENRRVYIRANQGHSLSGINPELVPITSETQVPFAVHGTYYSAWERIRGCGYLSTMGRQHIHFAKGMPGSDGVISGMRNTSEVLLVLDVPLLLKESVELWESANGVLLTPGVSGTGRLPLKYISSVVDRRTNDLLPR
The following text describes a protein:
Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). Regulates the activity of ventral cord motor neurons. Couples to the G(o)-alpha G-protein subunit goa-1 to negatively regulate cholinergic receptor activity in the presence of high levels of the neurotransmitter acetylcholine in ventral cord motor neurons. As acetylcholine depolarizes body wall muscles, modulation of acetylcholine levels most likely results in the control locomotory behavior and egg-laying.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, axon. Note=Diffusely localized in axons.
Sequence:
MAVASVLLALFMLFLSIVTVIGNLAVLLSYYLDKNIRQPTNYFIFSLAISDLLIGLEGIPVYTAFYLNNNEWIWGDVLCDLWLSIDYIVCLASIYTVLGITVDRYYSVKKPATYRNWRTPGRVVLIIIFIWLVPSILFSVSIFGYGTFTGTGRILKETECYVQFMTNPYLNMGMYISYYWTTLFVMLYLYWGIYRAAKKLALKSDQKTKRLALLTEMRRPEVSVRTSDAGNSSSDSPNDTSNSSKCFRTAPPTTTVQTTQTNVGTPPPVFRNHMTLHNNNMDFTKDNEIVRPPTPPDDNTYSNPNFSMISEQLTNGFSRQEPSSVIERESTAPCVSPEPSHASLENEFNENHHAHFKPELSLPFIDADSVSSMVGHDDLRRAMSIRISRSVSMQGTARATPVIEIVENLEEALKICENLEELREDENKNEEEKQKNGLENGGMNHVIIANDEQQPSTSKESEQKEEMTPENHDPNEVKVPLIAVSRVESVKSTAGGKVRRLITQMRSHSIRSKRKANKNKSVLSALNFFQRKKEYKSRSENRARKALRTITFILGSFIILWTPFYVLATIYGFCETCKASPSFNTLYTISYYLCYMNSPLNPFCYAMANQQFKKTLTRIFKGDFRRV
The following text describes a protein:
Function:
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect (By similarity).
Sequence:
MASPFSGALQLTDLDDFIGPSQECIKPVKVEKRAGSGVAKIRIEDDGSYFQINQDGGTRRLEKAKVSLNDCLACSGCITSAETVLITQQSHEELKKVLDANKMVAPSQQRLVVVSVSPQSRASLAARFQLNPTDTARKLTSFFKKIGVHFVFDTAFSRHFSLLESQREFVRRFRGQADCKQALPLLASACPGWICYAEKTHGSFILPHISTARSPQQVMGSLVKDFFAQQQHLTPDKIYHVTVMPCYDKKLEASRPDFFNQEHQTRDVDCVLTTGEVFRLLEEEGVSLPDLEPAPLDSLCSGASAEEPTSHRGGGSGGYLEHVFRHAARELFGIHVAEVTYKPLRNKDFQEVTLEKEGQVLLHLAMAYGFRNIQNLVQRLKRGRCPYHYVEVMACPSGCLNGGGQLQAPDRPSRELLQHVERLYGMVRAEAPEDAPGVQELYTHWLQGTDSECAGRLLHTQYHAVEKASTGLGIRW
The following text describes a protein:
Function:
May have a role in sporulation. Can compensate for the loss of cytochrome aa3.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKDDHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAFFVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNGKITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRKALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDPNEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLILYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLKTSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES
The following text describes a protein:
Function:
Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Plays a role in lipid droplet formation. Induces lipid droplet clustering.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Lipid droplet.
Sequence:
MEQPSVESLLELRRFPRKQLSLILLLLYSPLGLCLFLIRLFIGAHVFLVSCVLPDSVFRRFLLRVMSSVLGVYVSHSALRPLERRGKILICNHRTDFDHNIISLIAPCCSPSLSCAPGFLCWARGFLELGALGSRTQLMESLKHYLSQPGGGPLLLFPEEETTSGRTGLLHFSSWPFSLSDSVQPLTLTVQRPLIAAAVSGCSWVTELFWLLFIPFTVYQVRWLPPVTRHTRESDEEFAFRVQQMMAGSLGVAATRHTGADRAEYLKRRRTELPRSAPRSVPLSPTQMQMAQHVKEVLPQVPLSAIHRDLGHTGCIDTTITNFLEGRVTFLPEEETLGGNEATERTPIDRISRPLPRGFAKSPEVRHLSLQERKEALYECARRKYLEKFGSVGREEEEKGARG
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
PAGGGKAPSPRKSNVHTIQEEGRQQVRFRPNLEKEQRENVSARFSQTSGQTETVRRRGGDPVGVRENNPAVRAGDRPSAPKTAAVRVPSSDQLLVFERPPVKTVLCFGSRRTCWFPLKTRSSNQILHVDFLHLIPAAALPPPSSSSSSLRYRHETNKRFYSSNLCSSADSPQQHAFKEEDFVCPPELKWGLDLREPEPLQTAEELRRSRDDQEFAVKQEVDSFVEAAQQESSGPEPSGQHPLLFRYQDQNQEEGQHGALQPLGATEWMQDGISSREEDAAEGQSHLNPGKVLFNCDVCGKVFRFQYQLRIHAVAHTDERPFSCKVCGKSFKRKRCFLIHSRVHTGENLNACEICGKTFTKSSALTVHMRIHRGERPFSCQICGRSFTQNCALNVHMRIHRGERPFSCPICGRSFTQNCTLTVHMRIHTGEKPFSCQLCGRSFTQSCALSTHLRNHP
The following text describes a protein:
Function:
Has aromatic amino acid transaminase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MMRSDISNQISQELNNTNINLNGKSFNDYKFKEPIKDYSRYLSLRNSTPCQLTEVEISTFLASSEILSFGAGIPSKLFFPIKELEFNFNFLGNEKVRLSKEDLDLVQQYSDSPGLPKLRNWCKSIQQRHHGLCDPNTPGKEWNLLMTPGSQHALDCLVKAFFNRGDTLIVERYTYGGMFAVTQPSGINFAACEMDSKGMIPSELDNLLSNWESTHPDLKFPKLIYMIPHGQNPTGILYDMERKEEIYKIACKFDLLIIEDDPHFFLQLDNEIVNGKRVLNKSFLSIDKEDRVIRLDTFSKFLSSGIRMGFVTTNSKLFGVIAFELNASIFHSSGLTQIALEKLLTNWGDEKFDSHVNFVQEVLIRKRRETIELLEKHLKGQVEYSVPKAGLYFWVKLLGIDCSYEFVRDVLRHHKVIFGLGISSSPNRTIKTPYIRVTFSYLEKEDGEVAFKTLSDCLKDYIKNKKIIKHDEDVTLYNNIS
The following text describes a protein:
Function:
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
Subcellular Localization:
Nucleus.
Sequence:
MLSLPGLNLAPQPAEPLNAPTSTVTRTQDLAANTEYRFEVSFARTLTIKLQSGTAEFFGTELAPSTTYSFQGTKGAVFTWHGCKLEIGGEVESDYVAEETPMMSCANLHFALELLRDQSVSSGSAEMGPRVLVVGPEHSGKTSLVKVMTSYAAKTSRQPMVVNLDPRQGMLSIPGSFSAAAYSSIVDIEEGWGSSPISGPSPIPVKMPLVYHYGLKDPEEGKVFKPLVTRMALAVTSRLEEDKLSKQAGFIIDSSGAISQGRNGVYENIEHIVSEFSVNVLITLGSERLYSDLSRKYRNRDPSESVNVIRLDKSGGCVNRPEEYMKALRHAQVREYFFGHGDNTLAPSSQTCDFGDLHIFQIVEGDEGALYRSGDYDEYDPSNVSLASIYTRVTPSPSLQNSLLAITTASPTDSQDVIRDSSVKGYIYVADVDEAKKKVRLLSPQPGMIPGNAMVLGTWPEDVPGLVG
The following text describes a protein:
Function:
RNA-binding protein that protects nascent transcripts containing intronic transposable sequences, known as INE-1, from being degraded by DIP1. Modulates DIP1 activity by repressing its sumoylation levels. This ensures that intronic sequences will be degradated only after splicing. In the ovaries, regulates germline stem cells (GSCs) self-renewal by repressing the expression of the GSC differentiation-promoting factor Rga.
Subcellular Localization:
Nucleus. Note=Localizes to DIP1-positive nuclear bodies known as satellite bodies.
Sequence:
MTENTEKGASVETPQVAGSQTNPPVQEPLALTKIPPIKVKSERPDAEVEAKLRAMNAKIKAEMVTLMRRSNSNELGNNDESGESESSASADDKKNIKPVKSSNEILAELFGVFNAAPPEELLDDNLFKKKKKVKKEKKDKKAKKKKTTKSDGECSDSEAEGKHKHKRKKHKHKDIRVKDKEKDRDRDKSKEKDRDRVTDKSKEKDRDRDRDRDKSKDKFTAAQAPSEKEKEKSESRKRSAVEPSSHSEKRERHEREKHRDWEREREREKEHERERVRSNNSFYNGQREADRLKGSESASTKSRQEQDLSDISLSDEESYLREKASNGRRRAHNSFYDEKEELSVSPKRNVRESNTRRNRKSRSRSRDLGIDKKRLLEIARRNAINMFKQGTMPGVANMTAEVKDKVLVKMRYGGRTIQDLTDFCKKISNGDGLSDLSSEEESDVDKNGNAKVFHHPFQLKEREPIVMHIRNSTALVPAPPRLDEQTKAITMQFPVSSGQTHRNNEVWVPVDPKDSLVPLPSLPPAKQATNMFKETPKNVFAKSIPLQEQQEPAFKPLGGAVVVPPLAATQLPTVPQSVPPTVPKEFAPPAVPFVPEVPIPSTSPVTPMQSASIFPDVTPPSMDVSSIITQRLSAIRRLQENPADSEALKMMYTAQRNMSSWANSKHLPGQFTGSTGAQVMKAHELNSGPQLWVRKDQMTSTKPVTGGMGMALLQKMGWKPGEGLGRCKTGSLQPLLLDVKLDKRGLVSRDDLRPPQMRAPAAQRRNKNMAGPIGAGPCPAVQGAGPGPLASTPLVTQDKHPVCVLNELTSKNKWMPPQYKLRQDIGPAHNRSFLFSVEINGQTFTPDRGSNNKKEAKLNAAALCLRSLGILPPS
The following text describes a protein:
Function:
Required for bipolar spindle formation and proper chromosome segregation. Has a role in connecting the kinetochores and the plus end of pole to chromosome microtubules. Also required for the activation of the spindle checkpoint pathway.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Chromosome, centromere, kinetochore. Note=Kinetochore periphery. Spindle localization is alp7-dependent.
Sequence:
MSQDQEEDYSKLPLESRIVHKVWKVRLSAYEECSKSFSLSADGSDNCFELWNNQSELWKSVLTDSNVAAQEAGTAAFVAYCRFSDPSHLLKAREISVLSISEKCLTSPRAGTRENALEALMLLVEADSAAPVIESIIPSLSARSPKVIASNVAAIASLVEQFGAKVIPSKMIIPHISNLFGHADKNVRKEASRLTVNIYRWTGDPLKDLLFKDLRPVQTKELESLFAELPTEPPKQTRFLKSQQPTSEPNVETQVEEQPALENEESEPEPSDDQFDLVEEVDVLPNVDPNLETLMASSKWKDRKEALDKLLPVLSQPKIKDNDFFNLVAILTKSVSKDANIMVVINAAHCIQAMAKGLRSNFSKYASTSINALLERSKEKKANVIESLSSAMDAVLATSSLDDLAELIASFAGNKNPQIKSSCFSLFSRSFSNMTSLPSKFTVDTCAKACVPGVSDTFEPVRSAAAEALGVLMKLVGERAINQYLSPLDDIRKSKIRSFYETATVKAKAPTKKSKVKPSKQEESKVVVPSNAKAVKKSVVPSSPVVPSPRKATNKSLSMDVSKGNAFENGPLLPRPTTRPVSRGLSRGTSSSLQQKVKASTPLNSGALNETVQNLKNMELDDPAPQPAKHSRVDRYEHPKVLEDNDSTISSLESLKRENEELREQLKVEHEENISMQKQLSELKGELNTLRSARKASPIGDRKPAFMRRANTDFLELSTSPSFQRSVREFEPTRPKLYSSIDVNQRSPLASAKTNGNFTFHAELPRSPFSSRANNINPDWTKAIDLAAKLKQKITEMKQTDQRHQGLIH
The following text describes a protein:
Function:
Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
Sequence:
MGQIQYSEKYFDDIYEYRHVVLPTEVAKLLPKNRLLSEVSCLMSGVQLGFNRAEGGFTTQFTARSHTLCFSGGHLTTSSRSRRIKFSKTYSPSDQVPFMRF
The following text describes a protein:
Function:
Subunit a, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. With the subunit c (ATP5MC1), forms the proton-conducting channel in the F(0) domain, that contains two crucial half-channels (inlet and outlet) that facilitate proton movement from the mitochondrial intermembrane space (IMS) into the matrix. Protons are taken up via the inlet half-channel and released through the outlet half-channel, following a Grotthuss mechanism.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MTTNLFNIFDPSTTIFNLEMNWISTLLIILFMPNFLWILPNRMNWLLFKMFNMLNNEMLMLYKMKKTKSPAFLFISLFMFILLNNFFSLFPYIFSSSSHMVFSVTLAIPFWMFFIILSTCKNTKNMIAHLIPLNTPIYLAPLMTIIETMSIIIRPMSLSIRLTANLIAGHLLMTLLNFNSLMIIIIFIQMFMMIFELCVALIQSYVFSILSSLYSSE
The following text describes a protein:
Function:
Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.
Sequence:
MYISKIYPNDKRSLKLIDELLAKEEIRKDNNLDYTCAMFDDDMNIVATGSCFKNTLRCLAVDNSHQGEGLMNQIVTHLVDYEFSRGLTHLFLYTKNKSMKFFKDLGFFEIVNIENQIVFMENRRTGFSDYLDNLKKDLKVGKNIASLIMNANPFTLGHQYLVEKASSENDVLHLFIVSDDSSLVPFEVRKKLVIEGTKYLKNICYHETGDYIISSATFPSYFQKDEVAVIESQANLDIEVFTKIAKVLNINKRYVGEEPNSLVTNIYNQTMVKKLPENNIECVVVPRKKYSDNVISASTVRQIIKNGNLEDLKNLVPETTYNYFLSDEAKAIIDKIRSQDNVIHY
The following text describes a protein:
Function:
May be involved in tuning the metabolism, energy expenditure, and excretion processes.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle.
Sequence:
MGLGHSKAHPRVIKVTPLQSQETETPSTGPVFFALNRNLEEESSFTRLQDQNRTREGQLPPLRETWYGRLPAVSRAMYLDIPLKHEETSIIKRHPPRRIQKLEPIDLPQAITSERLLCHQEGRTKSNTKQENEKKIQLPMYTSGKRQYLHKMKMLEMNHKRQEAQMELRKSLLSKAMLDMQKLKDHNGNKIAQSKPRSNGYDILTILPNENINRDPGNPQDEEFLDCHTENDYYVRKIGKMETWLREQEARGQLFWDSSSSDSDELEKDERRPQALVRTKTEKIPLYDDFYDSA