lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RPB4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. The RPB4-RPB7 subcomplex is necessary for promoter-directed transcription initiation but is not required for recruitment of Pol II to active preinitiation complexes and seems to be dispensable for transcription elongation and termination. The RPB4-RPB7 subcomplex recruits FCP1 to Pol II. Involved in DNA repair of damage in the transcribed strand. RPB4 is dispensable under optimal growth conditions, but becomes essential during heat or cold shock and under nutrient depletion. Suppresses the RBP9-mediated transcription-coupled repair (TCR) subpathway of nucleotide excision repair (NER) but facilitates the RAD26-mediated TCR subpathway. Under stress conditions only, involved in mRNA export to the cytoplasm. Involved in mRNA decay. Promotes or enhances the deadenylation process of specific mRNAs and may recruit PAT1 and the LSM1-7 complex to these mRNAs, thus stimulating their decapping and further decay.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, P-body. Note=Seems to shuttle between nucleus and cytoplasm in a complex with RPB7.
Sequence:
MNVSTSTFQTRRRRLKKVEEEENAATLQLGQEFQLKQINHQGEEEELIALNLSEARLVIKEALVERRRAFKRSQKKHKKKHLKHENANDETTAVEDEDDDLDEDDVNADDDDFMHSETREKELESIDVLLEQTTGGNNKDLKNTMQYLTNFSRFRDQETVGAVIQLLKSTGLHPFEVAQLGSLACDTADEAKTLIPSLNNKISDDELERILKELSNLETLY
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MEFSLLPAQRESEVIGLVHMKHQEKSLLEKLHRKYSQKPWNETIKLTRLCLDKPVGNALKSVLYHPVLQCQNMLQEALQAKSLSVILSRIECISKQKGLESHLGPNERICYITSEMFYIEVQVKKNGNVSSVKLAHHGETPMVCNELLQFLRAKDFESFGQSLEGLLRLYNIPGNSEIKAKVYVALRSLEADLSGIFNIFSSKSTDKRESAILHGQVGFLSPRCGGTPMGIEYYVSPCQLLEEKLKPGSLVVGFKAYLSIMGTNNWFRLPSSPLFSGLQQDSNIPLFSLLNDECSMDLPACFCFMFTDPLPLLLPFVQKIQCITGLPVAGIKQAPFHELIIHLENNCCKTDGASTDAQFILSIPDCRDHCYAITSVSDNEQALMGILVDKIPFTHPSQVPATLEVLRHQAAYSTLINSCISSTRKTIEYTDMTHFEISLQRNCRICISFQHPSGVSLSCVAVDVLSSRQLNCTLYKDAVDPSFPCNSEFITKVLESCMSIPITMRAILKRSKKLGAVSKVETYSATEKSVHPLTTEGFERDVSMALDHDMEQINSPENKVLGQNKHKTVNDNLGHKMAMQSDEQNSTFAIEPYSFAARFSTSFAKESSPIMAEGPGALMAEVPDQVMLDGPSSIILEVQSPVLSEEPSSSMTEHSSSFTGDLSTSITEELNLNVSSFMVSSVIPEKKIEDSY
The following text describes a protein:
Function:
Probable transcriptional regulator essential for petal development. Required for the early development of the organ primordia of the second whorl. Acts downstream of AP1 and PTL.
Subcellular Localization:
Nucleus.
Domain:
Contains a slightly degenerated ERF-associated amphiphilic repression (EAR) motif, which may be involved in the activity of transcriptional repression.
Sequence:
MMDRGECLMSMKLRPMVTRPSSDGTLFWPFREERAFASAEEYGGGGGCMWPPRSYSCSFCGREFKSAQALGGHMNVHRRDRARLKQQSLSPSSTDQATPPECDRQQQVLDVGSKVLVQEETRKPNGTKREISDVCNNNVLESSMKRYEHDNGEVKTDLSVGLLSTEFDPRKKQLINGSSSSWKRAKTDVSRFPMMLGLVIGISEINGHHEELDLELRLGADPPKVN
The following text describes a protein:
Function:
Mediates the NAD(+) import into chloroplast. Favors the NAD(+)(in)/ADP or AMP(out) antiport exchange, but is also able to catalyze a low unidirectional transport (uniport) of NAD(+). Transports NAD(+), nicotinic acid adenine dinucleotide, nicotinamide mononucleotide, nicotinic acid mononucleotide, FAD, FMN, TTP, TDP, TMP, UTP, UDP, UMP, CTP, CDP, CMP, GTP, GDP, GMP, 3'-AMP, ATP, ADP and AMP, has low transport activity with cAMP, NADH and alpha-NAD(+), and has no activity with NADP(+), NADPH, nicotinamide, nicotinic acid, adenosine, thiamine mono- or diphosphate, inorganic phosphate, CoA, folate, NaCl, malate, malonate, citrate, fumarate, aspartate, glutamate, S-adenosylmethionine, lysine, arginine, and ornithine.
Miscellaneous:
MISCELLANEOUS: Appears to be a mitochondrial envelope-located membrane protein lacking an N-terminal-located transit peptide.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MIEHGNSTFDYRSIREVAANAGAGATAGAIAATFVCPLDVIKTRLQVLGLPEAPASGQRGGVIITSLKNIIKEEGYRGMYRGLSPTIIALLPNWAVYFSVYGKLKDVLQSSDGKLSIGSNMIAAAGAGAATSIATNPLWVVKTRLMTQGIRPGVVPYKSVMSAFSRICHEEGVRGLYSGILPSLAGVSHVAIQFPAYEKIKQYMAKMDNTSVENLSPGNVAIASSIAKVIASILTYPHEVIRAKLQEQGQIRNAETKYSGVIDCITKVFRSEGIPGLYRGCATNLLRTTPSAVITFTTYEMMLRFFRQVVPPETNRSDDRRREEERKNLVSRRGEEEDKDLGLRESQTQSNKISTPHIPLGSK
The following text describes a protein:
Function:
Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
Miscellaneous:
MISCELLANEOUS: Present with 3410 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle membrane.
Sequence:
MISGVLVYSSRGELVLNKFFKNSLKRSISDIFRVQVINNLDVRSPVLTLGSTTFHHIRSRHGDNLWLVTITRSNANSAAIWEFLYKLDAVMNAYRLDREEALKEEFMIVHEMLDIMLGGNGIPIDTELNSVIAQMSVKPVRNMGGLLDSPDGNDVLSSSSSPTSSAGELHFPKFLTKRSSSFLGQGDSTSDFYDNNKITWRPKGIIHKKDEVFLYVNERINILVSRDGSILKSYVDGTIDITTHLSGTPICRFGLNDSLGMQSEDEKKWLAQQQRHSGSDFGNKNFIPKAAAGSVLLEDCKFHECVSLDKFNRNHIIEFVPPDGSMELMKYHVRDNINLPFKVTPIVTHSTRDNEIDYRITLKSLFPGKLSAKDVVLHIPVPPSTVDCKISVSNGHCKFVPEENAMIWRFNKYNGLTENTLSAVTVSTSDTTQLNLQQWTRPPISLEFEVMMFSNSGLVVRYFTISGKDSKHRAVKWIKYISKAGSYEVRY
The following text describes a protein:
Function:
Reversibly inhibits the activity of ATP2A2/SERCA2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Binds preferentially to the ATP-bound E1 conformational form of ATP2A2 which predominates at low Ca(2+) concentrations during the diastolic phase of the cardiac cycle. Inhibits ATP2A2 Ca(2+) affinity by disrupting its allosteric activation by ATP. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. Also inhibits the activity of ATP2A3/SERCA3. Controls intracellular Ca(2+) levels in elongated spermatids and may play a role in germ cell differentiation. In the thalamic reticular nucleus of the brain, plays a role in the regulation of sleep patterns and executive functioning.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Sarcoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Membrane; Single-pass membrane protein. Note=Colocalizes with HAX1 at the endoplasmic reticulum. Colocalizes with DMPK at the sarcoplasmic reticulum.
Sequence:
MDKVQYLTRSAIRRASTIEMPQQARQNLQNLFINFCLISICLLLICIIVMLL
The following text describes a protein:
Function:
Toll-related receptor which binds to the neurotrophins NT1 and spz5. Essential for antiviral autophagy, it detects and binds to the vesicular stomatitis virus (vsv) following infection. This role is likely to be independent of the canonical Toll, immune deficiency, and JAK-STAT signaling pathways. Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe. Function in the Va1d ORNs is necessary and sufficient for correct targeting to their partner PN dendrites. Also involved in the targeting of other classes of ORN axons. Functions with Toll-6 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS). May be an upstream component of the NF-kappa-B (rel) regulatory cascade.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MAAILLLLLGFSWSLAVESALAPKESESSASAMLGAGTGAAATVSLSGDYSSLLSNVPAASPVPANPSQPSGPANQCSWSYNGTSSVHCALRLIERQPGLDLQGADGSSQLTIQCSELYLFESTLPVAVFARLQTLEALRLDSCKLLQLPNNAFEGLATLKSLRLSTHNSEWGPTRTLELFPDSLGGLKQLTDLDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLADINGVFATLVSLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRINNLTTRQHPRVMDMANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSNCTCYHDQIWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENATLAPLAALELIRIDGNRLVTLPIWQMHATHFGTRLKSISLGRNQWSCRCQFLQALTSYVADNALIVQDAQDIYCMAASSGTGSAALEDSSSNSGSLEKRELDFNATGAACTDYYSGGSMLQHGIPESYIPLLAAALALLFLLVVIAMVFAFRESLRIWLFAHYGVRVFGPRCEESEKLYDAVLLHSAKDSEFVCQHLAAQLETGRPPLRVCLQHRDLAHDATHYQLLEATRVSRRVVILLTRNFLQTEWARCELRRSVHDALRGRPQKLVIIEEPEVAFEAESDIELLPYLKTSAVHRIRRSDRHFWEKLRYALPVDYPTFRGNNYTLELDHHNHERVKQPASPGLLYRQAPPPAYCGPADAVGIGAVPQVVPVNASVPAEQNYSTATTATPSPRPQRRGEQPGSGSGGNHHLHAQYYQHHGMRPPSEHIYSSIDSDYSTLDNEQHMLMMPGAPGGLAMEAAQRAQTWRPKREQLHLQQAQAGTLGSKASQAAHQQQQQQQQQQQQQPNPTAVSGQQQGPHVQAYLV
The following text describes a protein:
Function:
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
Sequence:
MVRSDFRKWEAVKANVESDTVGFPLIRGSVWTGKNLSFIVSIDSLSLCSCFLLRDAEKPESCVREATARMGSTSAVNLEDVPSVNLMTELLRRLKCSTKPDKRVILIGPPGSGKGTQSPFIKDEYCLCHLATGDMLRAAVAAKTPLGLKAKETMDKGELVSDDLVVGIIDEAMKKPSCQKGFILDGFPRTIMQAQKLDEMLEKRGAKIDKVLNFAIDDAILEERITGRWIHPSSGRTYHTKFAPPKVPGVDDVTGEPLIQRKDDTAAVLKSRLETFHKQTEPVIDYYSKKGIVANLHAEKPPKDVMGEVEKVLSS
The following text describes a protein:
Function:
Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MHLNYLKVSGHRPKPTDLISCQLTFIHIMMFLTGGDIWLTDLFMSLNIENDFKCKATFYISRVMRGLSICITCLLSVFQAVTISPSTSLLARFKQTLTKSMKYSFLFIWSFNLSFSSNRFVYVGAYTNVSENNHMKVTKYCSLLPMNNIIRGLILTVTTSRDVFLVGVMLITSTYMMIILFRHQRQCKHLHSISQLRVSPERRATQTILLLVIFFVVMYWVDYIISSISVLFWMYDPVMLTVQKFVMNAYPTITPLVQISFDNRIIIILKNLQSKHHHVFF
The following text describes a protein:
Function:
Endolysin that degrades host peptidoglycans and participates with the holin protein in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.
Sequence:
MTLIVTRDHAQWVHDMCRARAGNRYGYGGAFTLNPRDTTDCSGLVLQTAAWYGGRKDWIGNRYGSTESFRLDHKIVYDLGFRRLPPGGVAALGFTPVMLVGLQHGGGGRYSHTACTLMTMDIPGGPVKVSQRGVDWESRGEVNGVGVFLYDGARAWNDPLFHDFWYLDAKLEDGPTQSVDAAEILARATGLAYNRAVALLPAVRDGLIQADCTNPNRIAMWLAQIGHESDDFKATAEYASGDAYDTRTDLGNTPEVDGDGRLYKGRSWIMITGKDNYRDFSRWAHGRGLVPTPDYFVVHPLELSELRWAGIGAAWYWTVERPDINALSDRRDLETVTRRINGGLTNLDDRRRRYNLALAVGDQLLTLIGDDDELADPTIQRFIREIHGALFNTVVTQSPYGDPQNPDGSEPRSNLWQLHELIKNGDGMGHARYVEESARAGDLRELERVVRAAKGLGRDRSPEFIARARNVLAQIEAANPEYLQAYIARNGAL
The following text describes a protein:
Function:
Probably plays an essential for replication of the chromosome, DNA recombination and repair (By similarity). Binds approximately 20 nucleotides.
Sequence:
MIGDYERFKQLKKKVAEALNISEEELDRMIDKKIEENGGIILKDAALMMIAKEHGVYGEEKNDEEFLISDIEEGQIGVEITGVITDISEIKTFKRRDGSLGKYKRITIADKSGTIRMTLWDDLAELDVKVGDVIKIERARARKWRNNLELSSTSETKIKKLENYEGELPEIKDTYNIGELSPGMTATFEGEVISALPIKEFKRADGSIGKLKSFIVRDETGSIRVTLWDNLTDIDVGRGDYVRVRGYIREGYYGGLECTANYVEILKKGEKIESEEVNIEDLTKYEDGELVSVKGRVIAISNKKSVDLDGEIAKVQDIILDNGTGRVRVSFWRGKTALLENIKEGDLVRITNCRVKTFYDREGNKRTDLVATLETEVIKDENIEAPEYELKYCKIEDIYNRDVDWNDINLIAQVVEDYGVNEIEFEDKVRKVRNLLLEDGTGRIRLSLWDDLAEIEIKEGDIVEILHAYAKERGDYIDLVIGKYGRIIINPEGVEIKTNRKFIADIEDGETVEVRGAVVKILSDTLFLYLCPNCRKRVVEIDGIYNCPICGDVEPEEILRLNFVVDDGTGTLLCRAYDRRVEKMLKMNREELKNLTIEMVEDEILGEEFVLYGNVRVENDELIMVVRRVNDVDVEKEIRILEEME
The following text describes a protein:
Function:
Cell wall formation. Synthesis of cross-linked peptidoglycan (PG) from the lipid intermediates (By similarity). Binds dansylated lipid II and catalyzes the polymerization of glycan chains. Hydrolyzes S2d (N-benzoyl-D-alanylmercaptoacetic acid) molecule, a synthetic thiolester analog of cell wall stem peptide. Active against bocillin, a fluorescent penicillin. No transpeptidase activity with non-fluorescent lysine-containing lipid II as substrate.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Secreted, cell wall. Note=Localizes to sites of new peptidoglycan (PG) synthesis at midcell independently of MacP.
Domain:
Has a penicillin-insensitive transglycosylase/glycosyltransferase (GT) N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits). Transmembrane signal-anchor is required for the synthesis of longer, 20-30 disaccharide units containing, glycan chains.
Sequence:
MKLDKLFEKFLSLFKKETSELEDSDSTILRRSRSDRKKLAQVGPIRKFWRRYHLTKIILILGLSAGLLVGIYLFAVAKSTNVNDLQNALKTRTLIFDREEKEAGALSGQKGTYVELTDISKNLQNAVIATEDRSFYKNDGINYGRFFLAIVTAGRSGGGSTITQQLAKNAYLSQDQTVERKAKEFFLALELSKKYSKEQILTMYLNNAYFGNGVWGVEDASKKYFGVSASEVSLDQAATLAGMLKGPELYNPLNSVEDSTNRRDTVLQNMVAAGYIDKNQETEAAEVDMTSQLHDKYEGKISDYRYPSYFDAVVNEAVSKYNLTEEEIVNNGYRIYTELDQNYQANMQIVYENTSLFPRAEDGTFAQSGSVALEPKTGGVRGVVGQVADNDKTGFRNFNYATQSKRSPGSTIKPLVVYTPAVEAGWALNKQLDNHTMQYDSYKVDNYAGIKTSREVPMYQSLAESLNLPAVATVNDLGVDKAFEAGEKFGLNMEKVDRVLGVALGSGVETNPLQMAQAYAAFANEGLMPEAHFISRIENASGQVIASHKNSQKRVIDKSVADKMTSMMLGTFTNGTGISSSPADYVMAGKTGTTEAVFNPEYTSDQWVIGYTPDVVISHWLGFPTTDENHYLAGSTSNGAAHVFRNIANTILPYTPGSTFTVENAYKQNGIAPANTKRQVQTNDNSQTDDNLSDIRGRAQSLVDEASRAISDAKIKEKAQTIWDSIVNLFR
The following text describes a protein:
Function:
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
Subcellular Localization:
Cytoplasm.
Sequence:
MKDEHNQEHDHLSQKEPEFCEKACKEQQYEEKQEAGEKEGEIKEDFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGAHKSAAEEDKESALTKGLELTMEKLHEVLARHGIEGIECLEEFDPHFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVLRPAMVSIAKND
The following text describes a protein:
Function:
Sodium-phosphate symporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MQALLKKLKPIVLGIALGSGLASLLRWSSLQRDPPSGVGQPGARSFTIDVQNEGKLVLPAVEPTRRFSRRYLPAGRGIKASGGPYVDRQPDRAASEDLRRTAEAGCGGKPSRRLRRLPIPLCERFRSGGSESVSARVGGALAAAANAGKAQSSLASPPTVTMVQFEQYTWIFAIGTIVSFVCAFGIGANDVANSFATSVGSRALSMPQAIMIAAVCEFLGALLLGAGVTDTVKNKIANVALFNNTPELLMMGMLAVMITAAFWDNFACHLELPVSTTHTTVGAIVGMAWVIRGRYAVVWSKLNINTATGDNDFPYLKGMSIIFLQWIVSPLSSGVLVAILFFLLRTFVLRSPHSFIRAFYLFPVLVVATFFVVVMFIIQTGNKNSSWEKVSDSKSVWVSAVVAAGMGVLTVAVIMPFLYKAVHAADSERERVEADQKMEAARIEAGELDPKEAAIMRAQANEQAALQSKDTMWHRSMEKYGVNRFAQTNAGKFIFGNAFVKTLTYGASYDVHSAIGNDIRVGTIWEGAEVFDFKTERLFRYLQIFSAMVMSFAHGSNDVANA
The following text describes a protein:
Function:
Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MGSGEKMIAMIVALSRSGKSVLHLDEKMNYGGFDGSFSLGQLTTLLEESNTELLKEKKDLIPPYFSNVIIKNYEQERLDKEEKERLEKERLEKENLEKKETEENKEEIENKEDSENKEGEENKEEVEIKVDEPSPVVVKEKTLNELGRMFSIDIAPTLLYSRGALVKLLISSSASKYLEFKSLDQNYLYINKKVHPIPSTKGSIFKDSAFSLKEKRLIMKFFESIKDLKSPEEPEKSTQLMNELSSKYQLFKDYIKSFQFTEQVESFVLYGVSLIHENLDSLSLVDGIESVFLYTSSLLVYGQSPFLLPYYGCGDIPQAFCRLCAVFGGTYVLGRTINTIQYKDNDHSNPIESVICSEGQTIKTKYLVSSPKYLNNSLLTSTTINTTKKTYSRFIGITNSRINGTEEQSFITIPPNSINNNKNVINILQFASICVPYNKGKTLIQITTLSTDNSKAEDDLKECVNVIIPNQEELLWSSFFNFTVENVDDSNNNLNNNNILVCSDSPLNATIDYEYHISQVKKLFEIISPNTPFLEKVPDSEDVIWGVEEISNDTPIQNDKEISSGELESTNEAAEIETLSTSTTYSTTTTTTTTTTTENNI
The following text describes a protein:
Function:
Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
Sequence:
MTLGNSYDAFNHDPWMDVVGFEDPNQVTNRDISRIVLYSYMFLNTAKGCLVEYATFRQYMRELPKNAPQKLNFREMRQGLIALGRHCVGSRFETDLYESATSELMANHSVQTGRNIYGVDSFSLTSVSGTTATLLQERASERWIQWLGLESDYHCSFSSTRNAEDVVAGEAASSDHHQKISRVTRKRPREPKSTNDILVAGQKLFGSSFEFRDLHQLRLCYEIYMADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLGRCGCLNVAPVRNFIEEGYDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIRKKVESQPEEALKLLLALFESEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLDAAEKVSRTKEFVTDGNMRVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSADTVELIERMDRLAEKQATASMSIVALPSNFQESNSSDRYRKYCSSDEDSNTCIHGSANASTNASTNAITTASTNVRTNATTNASTNATTNASTNATTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSSTNATTTASINVRTSATTTKSINSSTNATITESTNSNTNATTTESTNSKTSATTTASTNSNTSATTTESTNSKTSATTTASTNSNTSATTTESTNSNTSATTTASTNSSTNATTTESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDIYFCPEGVFTQYGLCKGCQKMFELCVCWAGQKVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKYFSVKRREIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEKKCQEEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELSLGMHLRDQIALGVTPSKVPHWTAFLSMLIGLFYNKTFRQKLEYLLEQISEVWLLPHWLDLANVEVLAADNTKVPLYMLMVAVHKELDSDDVPDGRFDIILLCRDSSREVGE
The following text describes a protein:
Function:
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.
Subcellular Localization:
Cytoplasm. Nucleus. Cell membrane. Membrane. Note=On UV irradiation, translocates to the nucleus and colocalizes with DAAX (By similarity). MACF1 is required for its translocation to cell membrane.
Domain:
The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2.
Sequence:
MNVQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDSRPVNHSFCSGKGTSIKSETSTATPRRSDLDLGYEPEGSASPTPPYLRWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEPCDSNEEKRLKLARAIYRKYILDSNGIVSRQTKPATKSFIKDCVMKQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGMSGYLPTLNEDEEWKCDQDADEDDGRDPLPPSRLTQKLLLETAAPRAPSSRRYNEGRELRYGSWREPVNPYYVNSGYALAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESIQVNGRVPLPHIPRTYRMPKEIRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMEEEGEDGEMPSGPMASHKLPSVPAWHHFPPRYVDMGCSGLRDAHEENPESILDEHVQRVMRTPGCQSPGPGHRSPDSGHVAKTAVLGGTASGHGKHVPKLGLKLDTAGLHHHRHVHHHVHHNSARPKEQMEAEVARRVQSSFSWGPETHGHAKPRSYSENAGTTLSAGDLAFGGKTSAPSKRNTKKAESGKNANAEVPSTTEDAEKNQKIMQWIIEGEKEISRHRKAGHGSSGLRKQQAHESSRPLSIERPGAVHPWVSAQLRNSVQPSHLFIQDPTMPPNPAPNPLTQLEEARRRLEEEEKRANKLPSKQRYVQAVMQRGRTCVRPACAPVLSVVPAVSDLELSETETKSQRKAGGGSAPPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEVREDEAVLPVFEEKIIGKVEKVD
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Chromosome. Nucleus, nucleolus.
Sequence:
MLGSKNMPWRRLQGISFGMYSAEELKKLSVKSITNPRYLDSLGNPSVNGLYDLALGPADSKEVCSTCVQDFTNCSGHLGHIDLPLTVYNPLLFDKLYLLLRGSCLNCHMLTCPRAVVHLLLCQLRVLEVGALQAVYELERILYRFLEENADPTACEIQEELEQYTIKILQNNLPGSQGAQVKNVCESKSKLISVFWKVHMTAKRCPHCKTGRSVVRKEHNSKLTITYPAMVHRRADQKDSEPQGIEEAQMGKRGYLTPSSAQEHLIALWKNEGFFLNYLFLGLEDVGMESRFNPSMFFLDFLVVPPSRYRPVNRLGDQMFTNGQTVNLQAVMKDVVLIRKLLALMAQEQELPSEVAAPTTEEEKDSWMAMDRSFLSQLPGQSLTDRLYNIWIRLQSHVNIVFDSEMDKLMMEKYPGIRQILEKKDGLFRKHMMGKRVDYAARSVICPDMYISTNEIGIPMVFATKLTYPQPVTPWNVQELRQAVINGPNMHPGASMVINEDGSRTALSASDLTQREAVAKQLLTPATGAPKPQGTKIVCRHVKNGDILLLNRQPTLHRPSIQAHRARVLPEEKVLRLHYANCKAYNADFDGDEMNAHFPQSELGRAEAYVLACTDQQYLVPKDGQPLAGLIQDHMVSGANMTIRGCFFNREQYMELVFRGLTDKVGRVKLFPPAILKPFPLWTGKQVVSTLLINIIPEDHIPLNLSGKAKIGGKAWVKESPRLVPGFNPDSMCESQVIIRAGELLCGVLDKAHYGSSAYGLVHCCYEIYGGETSGRVLTCLARLFTAYLQLYRGFTLGVEDILVKPKADVRRHGIIEDSTHCGPRAVRAALNLPEAVSCDEVQGKWQDAHLSKDQRDFNMIDLKFKEEVNHYSNEINKACMPFGLHRQFPENNLQMMVQSGAKGSTVNTMQISCLLGQIELEGRRPPLMASGKSLPCFEPYEFTPRAGGFVTGRFLTGIKPPEFFFHCMAGREGLVDTAVKTSRSGYLQRCIIKHLEGLVVQYDLTVRDSDGSVVQFLYGEDGLDIPKTQFLQPKQFPFLTSNYEVIMKSKHLHEVLSRADPQKALRHFRAIKKWHSKHSNTLLRKGAFLNYSQKIQAAVKALNLEGTNQNGRSPETYQMLRMWAELDEQSRRKYQKKAAPCPDPSLSVWRPDIYFASVSETFEKKMDDYSCEWAAQAERSYEKSGLSLDSLRTLLQLKWQRSLCDPGEAVGLLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMVASSNIKTPMMSVPVFNTKKALKKVKSLKKQLTRVCLGEVLEKIDVQESFRIGEKQNKFRVYQLRFQFLPHAYYQQEKCTRPEDILHFMETRFFKILMEAIRKKNSKASAFRNVNTRKATQRDLDNAGESERNRGEQEGDEEEEGHIVDAEAEEGDADASDAKRKEKQEEEVDYDSEEEEEKEEEEKEEEDIQEEGTGLKEGVQQEQEEGGWAPEESSLPGAPLTQPQKRARSREPQGAEAVERRAQAVRECHPFIEDYQYDTQGSLWCQVTLKLPLMKVNFDMSSLVASLAQGAIIYATKGITRCLLNETINSKNEKELVLNTEGINLPELFKYAEVLDLRRLYSNDIHAMASTYGIEAALRVIEKEIKDVFAVYGIAVDPRHLSLVADYMCFEGVYKPLNRFGIRSNSSPLQQMTFETSFQFLKQATLMGSHDELRSPSACLVVGKVVKGGTGLFELKQPLR