lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Cytoplasmic vesicle, phagosome membrane. Early endosome membrane. Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MAATLTLSTTMVATEENTDVQAITVFQEKDDFQDGVNQLLRPTEFCTHSVRLSKIRKDGEHRVRIVGVIVNNKGGHEACLMVFKRRHGDSLIIEDILPIYSDFRLTMTQSTPVNLNSPGSIEQSKGGFVLKVSSNKSNEVRFECADVQHLHGLLVEIKTAMAKAGKRCLLEAMGYLSSGKTHAWKRYYEQMRQDTLQSADGALGVRPSSAYRINSSVSNPFISHESNVSANILKSIKDSWAAQELRKREMQFSDYSKLKLCVGSWNVNGRLASESLVPWLGSKEAEDPDMYILGFQEVDLSTEVYIIGNNNMKEEEWSTAIEAALVASRTDKYIKIASKQLIGMLMIVYIRRSLYPFLHDVSTESVGTGILGMMGNKGAVGIRLKLFDSYLCFVNAHLAADTSMVDRRNQDYQEICRRLSFPLQSHFKNYIAYAQANAWVCNSMDAAPSLSGFPTGGGATMSNDNLFNLNRVLLSAFDADHLIWVGDLNYRVPISDAEAKAMIESNRLEELLNFDQLGIEQAASRCFNGFNEGQICFPPTYKYDVGTSRYDTSEKKRSPSWCDRILWFKNPLKVDDPEWLTITSYDSVQQLSMSDHKPVRAHFVAKIRKLNNEKLCESQDEITRGMDKFENEAQPDLVPDSNQVQFGNVRFMVPTTRTIEVENKGQVIAQYRFISPASDDRICKPWCYVSPSTGTLIPGGKIYIDITILVDKSTSPKLNAGRDHLEDILILHTENGKDHFITISGKWLPSSFGNPLGVLCRLARPIRSCTLTELCALYEEVEKAKSSQGGKSNITGSTGNIVDTANLAEANDEVQTNYDSPSPIPPAQVGDRLSFPRELWRIIDFIYKFGMDVDNLFLSTGDSAVTEYLRECLDTGVEFDLSVLLSDEIPENEVDTPCESPSGQSSPIPTDQLQQQTQSLTNTIVSDQSINIEELLSNLSKSNTASMPYVKLPRPRGRAVSVHSAAETLLRLLEALPEPIIPTFLHRRCVLEGYLTFAAARQIIQFLPKDHYSAFMYTTCFLREVLANYRGRGGLDEEKLARLFAPILLQIMNLDDNPKNGFSAIGVGSTIGTTNNAGASTSALPHVTGKGGGTFSPNASSVAVGLSPPKSTSSYLSSVLFGAIGGQWNSHSQQQSQQSTQQKVNAAMIGPPIPPEATSAEFRFFPHWFYRPNAPFLNGSLPEGMKDPWARREAWRSHPFFSLKSRIGLMIPGLTAGLASLGLYILYDQWYTTKGPGAAEAQYWKDWMVEREKRLHSEGQSHSTEAH
The following text describes a protein:
Function:
Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.
Miscellaneous:
MISCELLANEOUS: An excellent marker of acinar cell differentiation in the pancreas.
Subcellular Localization:
Nucleus. Cytoplasm. Note=In chronic pancreatitis associated with pancreas cancer preferentially accumulates in the cytoplasm of acinar/ductular complexes. In the cytoplasm loses its ability to form the PTF1 complex (By similarity).
Sequence:
MDAVLLEHFPGGLDAFPSSYFDEDDFFTDQSSRDPLEDGDELLADEQAEVEFLSHQLHEYCYRDGACLLLQPAPPAAPLALAPPSSGGLGEPDDGGGGGYCCETGAPPGGFPYSPGSPPSCLAYPCAGAAVLSPGARLRGLSGAAAAAARRRRRVRSEAELQQLRQAANVRERRRMQSINDAFEGLRSHIPTLPYEKRLSKVDTLRLAIGYINFLSELVQADLPLRGGGAGGCGGPGGGGRLGGDSPGSQAQKVIICHRGTRSPSPSDPDYGLPPLAGHSLSWTDEKQLKEQNIIRTAKVWTPEDPRKLNSKSSFNNIENEPPFEFVS
The following text describes a protein:
Function:
Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built; The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MPHLHFSYSPHYFSIEDIVLQDVRVSCKFEVAVPKLGMLDQSADDENLKQGSKVELPFWMVPTLHAKKIVTLEIPRHYKVNYRQILQADSIVVDLHKWGPYFYDLGLHVANLELKDSLDIKRSLVETLRNRLRQIMDMSQHSTHHETVHIIANLDELERKLFGVGQLSYRSYKEWVRRESSKINTATLVASHRKRKFAEVTV
The following text describes a protein:
Function:
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSTRTRNILIIVGALIISIASRFFLYTGPPHVEVAAEVIFDGIPGFPITNSFVVAIIIDIFVIALAVAATRNLQMVPRGLQNVMEFILESLYNLFRNINAKYVATAFPLVATIFLFVLFGNWFGLLPGVGSIGVCHEKKEEHAVVDERLALAAPAAPLSSVAAAEGEEIHDTCAAQGKKLVPLFRAPAADLNFTFAIAVISFVFIEYWGFRALGPGYLKKFFNTNGIMSFVGIIEFISELVKPFALAFRLFGNIFAGEVLLVVMAFLVPLLLPLPFYGFEVFVGFIQALIFALLTYAFLNIAVTGHDEEHAH
The following text describes a protein:
Function:
Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus.
Sequence:
MEPTAGSEMESGGGAATGACVTRIPVPRPPSIEEFTIVKPISRGAFGKVYLGQKGDRLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTPSMAKPRQDYSRTPGQVLSLISSLGFHTPVAEKNLDPANILSTHASETSQLSQGLTCPMSIDQKDITPYSSKLLKSCLETFASHPQMPVKCLTSHLLQSRKRLATSSTSSQSHTFISSVESDCHSSPRWEKDCQESDNTVGSTVMSWNTAEKPSCIHSTNAAESKSFNKRDFELALSPIHNSSAIPAPGNSSVNLAKESSSGNVSWEARELDINNINVAAGTRQSRQWTVDSSGITEEHLGKRSCKRSFELIDSSPCQEIIQNKKNCIEYKHSNEMKDCYTNQRTGLTTEVQDLKLSVYGDQQNDCANKENMGNTFSDKQQTPEKSPIPMIAKNLMCELDDDCDKNSKKDYLSSSFLCSDDDRTPKSIHMDSDSSFPGISMMESPLGRQSLDPDKSIKESSLEGSKIEDLLPTSPSCQEGTLLRGDENPAHQDRNPKMLAPSSEVLKTITSKRNAVAFRSFNSHINASTSSEPSKMSITSSDVMDMSCAYSGSYPMTLTPTQKERSYMPYQTPNQAKSGTPYRTPKSVRRGAAPVDDGRILGTPDYLAPELLLGRTHGSAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKHHPLFNDVDWENLQHQTMPFIPQPDDETDTSYFEARNTAQHLTVSGFSL
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.
Subcellular Localization:
Cytoplasm.
Sequence:
MGKNQFDEKKPEWVSLHQHTEYSLLDSSAKISDLIKRAKEFGMKSIAITDHGVMYGCVDFYKEAIKQGIKPIIGCEIYVASKSMYIKQQDKENETHHLVLLVKNEIGYKNLMEIVSKASVEGFYYKPRVDHEFLKDHSEGLIALSACLGGEVQANILKENLEKAEEVALIYKDIFKEGFYLELQYHGMEEQLKVNETLVKMSKDLDIPLVATNDVHYIRKEDYKSHDILLCIQTGKTVEEENRMRYPSDQFYLKSPEEMYETFSYVPEALENTVKISEECNFDYNFHESKLPKFPLEEGVDPYEYLREICFKGLFLRYEVLKDFIDKPFSIDEVLVYGDENKEAFDLIERLNYELSIIQQMGYVDYFLIVWDFIRFANEKGIMTGPGRGSAAGSLVAYTLGITKIDPIKYNLIFERFLNPDRISMPDIDSDFCYERRGEVIDYVVEKYGKENVSQIITFGTMAARACIRDVGRAMNYPYAEVDRIAKMIPTVLNITINKALELNPELKEVYDNEERVRELIDVARALEGLPRHTSTHAAGVVIASQPLVNYVPLQRNEESIVTQFTMGTLEELGLLKMDFLGLRTLTVMRDAVRIIKENKEINIDLDNIDFEDKEVYKMIGQGKTVGVFQLESAGMTSFMKELKPDSLEDIIAGISLYRPGPMAEIPRYIANKNNPLNIEYQTEKLEPILSVTYNCIVYQEQVMQIVRDLAGYSMGRSDLVRRAMSKKKHDVMEQERRNFIYGNEDQGVKGCINNGIDENVANSLFDSMMDFASYAFNKSHAAAYAVVGFQTAYLIRYYPTEFIAAMLNSVKGDNDKVSFYVNFAKTLGIEIIAPNINESYSNFTVKDNRIIFGLTAVKNVGEKGIDNIVLSREQKDKFIDLSDFFNKVDTSIINKRLVESLIKAGAFDCLKVYRSKMLAVFEKIMDGIQKQKRNNIEGQVNLFMDIMDNKESSIDIKYPNIKEFDKKYILQMEKEMTGLYFSGHPLEEYEETLKIQTSHLISDIIPKESLEGNLVDTISSIKDGDKVVVGGMITHVSKKLTRNNDMMAFIVLEDLYSSIEVIVFPKIFNMARNIINEDEVVLLKGRVSLREDEQPKLICEFMEPLVKINSEKLYILVEEKKDIKLKLQEIKGVFLQHKGNIPVYFCTNKERKKFRIDRELWVNGSRELMDNLRNMFGEDNVKIL
The following text describes a protein:
Function:
Transports electrons between ferredoxin and NADPH. May supply electrons to P450 systems. The enzyme can use both NADPH and NADH as a reductant, but the catalytic efficiency is two orders of magnitude higher with NADPH.
Sequence:
MRPYYIAIVGSGPSAFFAAASLLKAADTTEDLDMAVDMLEMLPTPWGLVRSGVAPDHPKIKSISKQFEKTAEDPRFRFFGNVVVGEHVQPGELSERYDAVIYAVGAQSDRMLNIPGEDLPGSIAAVDFVGWYNAHPHFEQVSPDLSGARAVVIGNGNVALDVARILLTDPDVLARTDIADHALESLRPRGIQEVVIVGRRGPLQAAFTTLELRELADLDGVDVVIDPAELDGITDEDAAAVGKVCKQNIKVLRGYADREPRPGHRRMVFRFLTSPIEIKGKRKVERIVLGRNELVSDGSGRVAAKDTGEREELPAQLVVRSVGYRGVPTPGLPFDDQSGTIPNVGGRINGSPNEYVVGWIKRGPTGVIGTNKKDAQDTVDTLIKNLGNAKEGAECKSFPEDHADQVADWLAARQPKLVTSAHWQVIDAFERAAGEPHGRPRVKLASLAELLRIGLG
The following text describes a protein:
Function:
Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.
Subcellular Localization:
Melanosome.
Sequence:
MGKKLDLSKLTDDEAKHIWEVVQRDFDLRRKEEERLGGLKDRIKKESSQRELLSDAAHLNETHCARCLQPYRLLVAPKRQCLDCHLFTCQDCSHAHPEEEGWLCDPCHLARVVKMGSLEWYYGHLRARFKRFGSAKVIRSLCGRLQGGGGPEPSPGEGSGDSEQTEEDGELDTVAQAQPLGSKKKRLSIHGLDFDADSDGSTQSSGHPPYLSPVPMATDSLQTLTGEPRAKDTSQEAVVLEEADVGAPGCHPHPEEQTDSLSAARQDTLTEPRFPRQSCTTALGLAVTPGPGVISSSERLSSRYPADEGTSDDEDTGADGVASQSLTWRDCAPAESQHLTGHQPTDADREEETLKRKLEEMTSHISDQGASSEEEGSKEEEAGLNRKTSIEDLPGAAPEVLVASGQTSRQETSPRGPQELMQPGRTTDQELLELEDRVAVTASEVQQVESEVSNIKSKIAALQAAGLSVRPSGKPQRRSNLPIFLPRLVGRLGQTPKDPNAEPSDEVKVMTAPYLLRRKFSNPPKSQDKAGDSFDRQSAYRGSLTQRNPNSRKGVANHSFAKPVMTQRP
The following text describes a protein:
Function:
Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNDNPGDGEVIRQGSKISWLTFTLVCIFSMSSWIGTNGIWVETPLLVARTPGGLQLPAVLTIISHLGAIGPACYGLAYYYHPRRFNEAPFIYILLIVAVINSLALAIFWNKTFVAMSTFEHSVALYFIAFIFSFVGCMSIVTFLPYMADYPEIYITGIFIGDGLSSLIPGIAILIQDVTDGPKCHHHLNISKANGTTVSENPIFGPDTLFFIVFTFLLISLVSFTVLDHLPSSVRIYDRKIKKNIFRMQRDILNEAEIQLQARNGVSTSNETSDSESEQDGRCRRMKNRLFTSHINDSHYITPKMAKFCLPFCEEASNANMETSESERLSTNQDRYQTDNESNKAVEWVSHADKQRYIILLLTEGWAFCISNGVLPSIQPFSCLPYGLKTYHRTVASVAVTYPLSSVFAVLLFKYRSMTAVFYTSTLSRATGIFIITSAVMSPYPPLHNTVQGSILIVRQVRDKFVK
The following text describes a protein:
Function:
Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus membrane.
Sequence:
MSFVSSETPNAIASSSTAHAGSANSRARHRLDNGLRYHSNHLSSDCRPLPRSAPRKQRVASKSKKLRWRKGLVTEAFRKFGEHCARNQIRTLLIDCLVMTNLFYPSLALYLPKRFPPPSPRAVQDAHWPPLDNDVTSPYRTNVDHPLSFSTLGRLFPSAPPLLPRLTWAGWWGSGTREREDDGWTATRAIPGAKEIGEGQNDQVWVMRIGWADVEDVLDRHIEDGERKWEERDHHLLKLVQNVAENWERQIPSNRQRCVRQLKSSTSVRGDGVDSEPPPCYVLTPSPDAFDSAIPISMSGFVHFDHGVSASPDSVPLGRSPNPDNIYHTFAALFHVPQNSTSAFEQRWQSAMSDVAKEVEGEVFVEAKGPRVGDQIGEWFISYASSPLSQQPNLTGPISSDRSKIFSSSPPPIIIVLYVILFTTLIVQLSNASKAHSRFGLAFTGVVQLCCSSVMSFSILALLGWNGWGVPHAESSLPTYVLPFVIVVVGAENMSTLTQAIFSIPFTHSVPVRIGLGLSKVGTTIALTSLTDLGILSVVWLCVNLQPVREFCLFAAVVIVTDWFMLHTFFLTVLSIDAQRLELADVLASNKVGMVSPVESTGEKDAQNENQGFLWRNMLRARTTKSGSLLLLLFTVGLLYWLTERHRSPLNTTASLYGYTPTARSTSVSVPTPTASPFVSTPEAISVLSSAEKLWRALNPEGWPFAHVIVPPASILVLPKFGHSMRPGDIRKLSLPASRLLIPRLKALFYIFKVLVLPQAITAGALYALLLYLLKDADLLDAQRNRLGRMGDAHEDESDFRGSTKNASGLLNCLRARMLPCSHEADVDVIASSSDGRIAISVAIDNSVCLWRFLDTPGSGTREPLPTGGLDGGDAIVAAAVSEDGQHVAVCTNMAVVQIWEVPREGAVVPLQVRKPEQTFTAKILGIAFDETAPNVDDPFTANEPATEEARKATSIMIGYGDGSVMALTEMDAKVVIPAQDRGAYSSCRVLFMREIGGSVSILIARQHDIDIWRKSTFGWVSSSLIADLPGEDRVTALSPLNAELPGVFAVGRRSGNITIYDESHGQLELMPQGSSIEGVRKIQLVRPSSMKCLGCGLQSAEGYAIISSTSSQVSIDRIAPRTSIPTFCRCTRRVSSADDVPALMHRSDSPQRSKPNSLIVPPVTFRQRPTPGSSPHKSISLLSPVSNGEFPLSSHGSARRSSNFHREDDSLKIISSPHDRSALSSIGGGSGLVSPSGDMEVTSLGGISAQGASDGGWAILDGDVLVGVRRGREGIDDAQWQVWSVDMTAPWDMAGLVVDSIDLSELQRRTFEADCTIRGQASGGGSTNGVVSMRDRRTERLLSLNGRASFPERVGSFAVPTYESLGYVEVVGLNILGTKGMIGGFGNRLGTISLERFEEKKVIGRSSMDGQLGMGLGGLTPTRRQSLFPLTPPPPCDGSIGRF
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
FPLLAFFCLTAGCMNMQNYSSVTEFILLGIPNSEGLENMLFVLFLAFYLLTLLGNLLIFLIILVSSNLHTPMYFFLGNLAVFDIFFPSVSSPQMMLYLMGQSRTISYQGCASQIFFYHFLGGTECFLYTVMAYDRFVAICHPLQYTVIMNHRVCTGLTLGTWLGGCLHGSILTFLVFKLSYCGPIEVDSFFCDIPVVLPLACTDTSLAQTVSFTNVDIVTLTWRSRTFSTCSAHLISILLFYGPVMLIYLRPASSPWLDSVIQVLNNIVTPSLNPLIYTLRNKDVKLALRKVLSQMVHSSGV
The following text describes a protein:
Function:
DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity. DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde. Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis (By similarity). Catalyzes proteolytic cleavage of the HMCES DNA-protein cross-link following unfolding by the BRIP1/FANCJ helicase (By similarity). Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as TOP1, TOP2A, histones H3 and H4 (By similarity). Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs. SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs (By similarity). Involved in recruitment of VCP/p97 to sites of DNA damage. Also acts as an activator of CHEK1 during normal DNA replication by mediating proteolytic cleavage of CHEK1, thereby promoting CHEK1 removal from chromatin and subsequent activation. Does not activate CHEK1 in response to DNA damage. May also act as a 'reader' of ubiquitinated PCNA: recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to sites of UV damage via the PIP-box. Recruited to stalled replication forks at sites of replication stress following deubiquitination. CHEK1 stimulates recruitment to chromatin.
Domain:
The PIP-box mediates the interaction with PCNA, while the UBZ4-type zinc finger mediates binding to 'Lys-48'- and 'Lys-63'-linked polyubiquitin.
Sequence:
MDEDLVVALRLQEEWDVQMARRAAAAREPVSLVDASWELVDPTPDLQALFLQFNDRFFWGQLEAVEVKWSVRMTLCAGICTYEGRGGMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFVTNNDKDREGHGPEFCKHMHRINQLTGANITVYHTFHDEVDEYRRHWWRCNGPCQHRQPYYGYVKRATNRAPSVHDYWWADHQKTCGGTYIKIKEPENYSKKGRGKTKADKQPASAVENKDKLCRGEAQLLIPFSGKGYVLGDASTCPSAGKLNTSYMVNEAKGLSSQDHSVSGLRLNSNAEVKCEQNCLPKKPHLVSPLPTASHQSVLSSYFPRVSVANQKAFRNVNGSPVKNGTTGDGTKRPASGGSQRKVPPSRASLRNTSKVTAPASATVTSAAGTSATISREESGSEDQFLNKRPRLEDRTALDTIKEQTQSGGDLRSSSQPTAASAPQSLSSQRRLVNCPVCQGVVVESQINEHLDRCLEGNKTNLRPRRV
The following text describes a protein:
Function:
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MIILSNKPNIRGIKNVVEDIKYRNQLIGRDGRLFAGLIATRISGIAIGFLLAVLLVGVPAMMSILGVI
The following text describes a protein:
Function:
Also acts on cytidine.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTVSKIPIWLDCDPGHDDAIAILLGCFHPAFNLLGISTCFGNAPPENTDYNARSLLTAMGKAQAIPVYKGAQRPWKREPHYAPDIHGISGLDGTSLLPKPTFEARTDKTYIEAIEEAILANNGEISFVSTGALTTLATVFRCKPYLKKSVKYISIMGGGLHGLGNCNPNLSAEFNVWIDPDAANYIFRDPDVKDKCIVVPLNLTHKAIATYKVNEMIYNEKNNSKLRELFLELFQFFAHTYKDMQGFESGPPIHDPVALMPLLEFYGWDPSSAVGFRYKRMDISCIDDVFNENSGKIIIEKEYPNDSDVGTIIGLDLNIQYFWDQIFEALNRADKMSTIG
The following text describes a protein:
Function:
Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.
Sequence:
MNFSLECIVDEVKSVLQGRTTSRGFYAVGLQFPEGLMEQAIEVCNALEGMLKAANGVAIEYVIFADVLYGACNIDDIGSMLMGVDVLVHFGHSKIVPTSLVDVIYVPVIDTRGSATVIADGLMDMCRTHSYKTVGLVTTAQFAACLLHVQPILDDRGSKINIVGEEQSPLPKYEILGCTCKKFPPGTDAVVSVVDGDFHYEAACLSNSHLPAYRLSPVTGVYESIRYDTHSKINSRLKTIRECAEALTELLNRPVQAFAGGFSGKRVGVVFGTLGRQGSPIVFETLLNKLRSLCVPIKVLSLSEVLPHYLLPHKDVLFFAQLACPRLTIDWDEEISACGLVMVNYYELDKILDLCLKKEGYNDLEDYALVNFTRDGHRELCYYGRPTV
The following text describes a protein:
Function:
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Sequence:
MSEPYKPSTLKHGEELCQELASNNSIDSVGILDDEGNTIASKGFNITPQEFKDIKYILINDKPDYKLGTITINNVTYNELTKYSDGLYYAKAGETGCVIAKNIKSLIVATLHCKHTSSLFDACEKIKSTSQFIKFDGY
The following text describes a protein:
Function:
Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MMAINSASFVALSYLFSLLMAFPMPDSPQTSSSGFRLFEAHQAPRSFTKREIPQSHKHTLNLKIALKSGGMDLIKKRLVETSDPESSSYGRHLTFEEIRDLSAPSSSSLEAIVKWLSSHGFDESAMDWSHSKDWVSLNQVPLQKAEEMLDTTYFYYQHDDGEMLLRTERYSLPEEIHSHVELIQPTTMFGRLAPKRSMFTSEMSNQRKHKSIARIRNNRRTFPIFNTPAPAQTAVNTTACKDPASVTNACLRELYQTDSYRLQTQGNANRIGVTAYIGERANYEDLKDFLMNEGLPTTNNFTVVSVNGGLNPQTHTVDELARHVGVEGNLDIQTTMGFTAPMPNIFYTTAGSPPFQADLFTPTNSNEPYLDWLLYIASQPDSAVPQVISTSYGDDEQTVPANYAKRVCDQLAALTARGVSLIFSSGDDGVGQAGTCLSNDGKNTPRFMPIFPATCPYVTSVGATQRFHPEEAVSVDGPGGFPSGGGFSEYFDRPQYQSQQVQTYLNLLGSNYTGLYNPKGRGVPDVSAQGAKYLMTWQKLHVHVGGSSAAAPTFASVIALLNDNRIARGMPALGFLNPWLYSQGYKALNDIVIGSSSGCGTTGFAAAKGWDPVTGLGTPNFPAMLRAMPAQDTLSSRPDPTYCKSSIMSMVNCHLGWRVPGF
The following text describes a protein:
Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
Subcellular Localization:
Nucleus.
Sequence:
MDHPLDHLFSDNVALEGENDGEILSDDELPDGDADGSGDEATDAAPAKPVAVEVKKKTVRNPRNMLNEAKLCGPRGIIALKDHFKHFKFHGKGHEASDLNRLMRNYEHWAHRLYPKFHFDDCMAKIEKLGHKKQVQMYMNKYRTGMLQAEMEAMAQAAANSADEEEPDVSQLNRPLDPLDSMLEEQIARSRGRTSVANTSGIGNLSMDNTFDAVRQTDNGAVHANALKDTHQQQTVKSPPVADEIRAKIEANRLKALELRKARLQALSQQSSPGGAENVENDSCGLPPS
The following text describes a protein:
Function:
Thiamine transporter involved in the cellular uptake of thiamine. Pyrithiamine, oxythiamine, amprolium, and the thiazole part of thiamine have been shown to be also substrates of thi9.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MPSSQISHQDPELGQTSSGSSSIKEKAEPQLYAGPIDPARRPDVFQEGFEDVSVTDDDNDNELLRKMGYQPVLHRSFEFFESFAASFASLDVVSGVRLTFSWGISFGGPAAYWSAMLVTGFCSIVTAACLAEICSALPAAGSIYLWAAESAGPRFGRFVSFLVAWWSTTAWTTFVASITQSTANFIFAEVSTFNNPWPTNDSDVKFRAVQWIVAEVLLVFTILLNQVPPRYYKWIFKASMLLMFIDYVMNIIWVPVATSKKPDGFRSAKWVFTETIYDQAGYIKEVDDANGNPIASLSKIVPKGWQWCLSYFATAGVIVGYDASGHIAEETKDASIKAARGIFYSTVTSFIVAFSLAILYLFCCPDLDTFTAILYNDNSPQPFVNFYSYLLGRGGHVVMNVVIILEIFLNGVVSVLACSRLVFAVSRDGVLPFSNWISQVSKTGQPKNAITVIYIVSALLLCTILPSAVAFTSLVSAAGAPSFAAYAVLAFCRLFITRDKFPKGRWSLGWLSKPCLVITLVYNLFALVVNVSPYTYPVTGPSFNYAVVIMGGVSIFAIICTIVIPKSRWVANRYRYESDSEHSASVKELKV
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 7700 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MWKRSFHSQGGPLRARTKFTKPKPKQPVLPKDKIRPPTQLTHHSNNLRITEPIPPTTSNLRCPDDHPLWQFFSNKKFIRSADDLPPSSHIRPWSIPELRHKSFNDLHSLWYNCLREQNVLARENHLLKNIVGSTHDEFSELSNSIRTTMWQIRHVLNERELAYSASREFLQDESERKKFLDTLANDYFLNKDIPDDEVASMLTRFQLAIFGISETIQDNTVDINFIDGIKFLANLKLQRFKDSNDLISEISQEPITDVGESFILFTSDFEPHAVQEACVAIKDLRKSPDNKVPKLDELPTVRKYLKQLIHASSVEQATA
The following text describes a protein:
Function:
May act as a deubiquitinating enzyme.
Sequence:
MESPSARTLGNSLGDDSGNGNENGNGSGNGNTTMMPHGIYHERQTRHLCGLHALNNLFQGPDMFSKSELDDYCTTLTPRNWLNPHRSWIGWGNYDVNVIMYALQQRNCEAVWFDRRRDPHCLNLSVIFGFILNVPAQMSLGYYIPLPFHMRHWLALRRLNGSYYNLDSKLREPKCLGTEQQFLEFLATQLQMDHELFLVLDEETDCKDKSQQRWLLPQFRD
The following text describes a protein:
Function:
Possible sulfate transporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAHQWVLNAPEPPSMLRQVVDNVKETLLPHPNPNTFSYLRNQPFSKRAFALLQNLFPILASLQNYNAQKLKCDLMAGLTLAIFAIPQCMGNATLARLSPEYGLYTGIVPPLIYAMLASSREIVIGPGSVDSLLLSSMIQTLKVPIHDSSTYIQLVFTVTFFAGIFQVAFGLFRFGFLVEHLSQATIVGFLAAAAVGIGLQQLKGLFGIDNFNNKTDLFSVVKSLWTSFKNQSAWHPYNLIIGFSFLCFILFTRFLGKRNKKLMWLSHVAPLLSVIGSSAIAYKINFNELQVKDYKVAVLGPIKGGSLNPSSLHQLTFDSQVVGHLIRIGLTIAIISLTGSIAVGRSFASLKGHSIDPNREVVSLGIMNIVGSLTSCYIASGSLSRTAVNYNAGSETMVSIIVMALTVLMSLKFLTGLLYFTPKAILAAIILSAVPGLIDLNKAREIWKVDKMDFLACTGAFLGVLFASVEIGLAIGCRSRYHLRR
The following text describes a protein:
Function:
May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Concentrates in discrete patches along peripheral endoplasmic reticulum tubules.
Sequence:
MKRCRSDELQQQQGEEDGAGLEDAASHLPGADLRPGETTGANSAGGPTSDAGAAAAPNPGPRSKPPDLKKIQQLSEGSMFGHGLKHLFHSRRRSREREHQTSQDSQQHQQQQGMSDHDSPDEKERSPEMHRVSYAMSLHDLPARPTAFNRVLQQIRSRPSIKRGASLHSSSGGGSSGSSSRRTKSSSLEPQRGSPHLLRKAPQDSSLAAILHQHQCRPRSSSTTDTALLLADGSNVYLLAEEAEGIGDKVDKGDLVALSLPAGHGDTDGPISLDVPDGAPDPQRTKAAIDHLHQKILKITEQIKIEQEARDDNVAEYLKLANNADKQQVSRIKQVFEKKNQKSAQTIAQLHKKLEHYRRRLKEIEQNGPSRQPKDVLRDMQQGLKDVGANVRAGISGFGGGVVEGVKGSLSGLSQATHTAVVSKPREFASLIRNKFGSADNIAHLKDPLEDGPPEEAARALSGSATLVSSPKYGSDDECSSASASSAGAGSNSGAGPGGALGSPKSNALYGAPGNLDALLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQVVQLEGVENANARALLGKFINVILALMAVLLVFVSTIANFITPLMKTRLRITSTTLLVLVLFLLWKHWDSLTYLLEHVLLPS