lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork.
Subcellular Localization:
Secreted. Golgi apparatus. Cytoplasmic vesicle. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Secreted, extracellular exosome. Mitochondrion. Mitochondrion intermembrane space. Mitochondrion inner membrane. Mitochondrion outer membrane. Rough endoplasmic reticulum. Cell projection. Cell projection, cilium. Note=Located preferentially in the ciliary rootlet and basal body of the connecting cilium of photoreceptor cells, and in the rough endoplasmic reticulum. It is only imported to mitochondria in the trabecular meshwork. Localizes to the Golgi apparatus in Schlemm's canal endothelial cells. Appears in the extracellular space of trabecular meshwork cells by an unconventional mechanism, likely associated with exosome-like vesicles. Localizes in trabecular meshwork extracellular matrix; [Myocilin, C-terminal fragment]: Secreted; [Myocilin, N-terminal fragment]: Endoplasmic reticulum. Note=Remains retained in the endoplasmic reticulum.
Sequence:
MPSCAYCCSCGPKMPALQLLFLACLVWGMGARTAQFRKANDRSGRCQYTFTVASPSESSCPREDQAMSAIQDLQRDSSIQHADLESTKARVRSLESLLHQMTSGGVTGTQEVQEGLQGQLGALRRERDQLETQTRDLEVAYNNLLRDKSALEEEKRQLEQENKDLARRLEGSSQEVARLRRGQCPSTHHPSQDMLPGSREVSQWNLDTLAFQELKSELTEVPASQILKNQSGHPRSKEGDKGCGVLMWVGEPVTLRTAETITGKYGVWMRDPKPTHPYTQETTWRIDTVGTGIRQVFEYSQISQFEQGYPSKVHVLPQALESTGAVVYSGSLYFQGAESRTVLRYELNTETVKAEKEIPGAGYHGQFPYAWGGYTDIDLAVDESGLWVIYSTEETRGAIVLSKLNPENLELESTWETNIRKQSVANAFVICGILYTVSSYSSVHATINFAYDTNTGISKTLTIPFKNRYKYSSMVDYNPLERKLFAWDNFNMVTYDIKLSEM
The following text describes a protein:
Function:
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
Subcellular Localization:
Cytoplasm. Note=May associate with membranes.
Sequence:
MRMKRASKVIFYNRLSTIQLFNISEICGCQIIDKFQLILEIFAKRATTRRSKLQVELARLRYEVPRARAIVSLVKKEERAGFMGLGDYEDAYEQDLKKRISRIENELESAEKDDESLRAFRHRKGFSLVSFAGYTNAGKSTLFNAIVDESVEAQDKLFTTLVPTTRALDLGGRKALLTDTVGFIEELPHWLVDAFKSTLDEIFLSDLILLVVDVSEKPETILQKLSTSHDTLWDRIQGVPVITVLNKTDLLEASELEAAMEEIGYMAPNPVFVSAKEKLGMKELKAEIIKHLPAWSSYSFTLPNSEKGMSVLSWLYDEGIVHRVDYGERISVDYEARTEIINRIKALELNQGE
The following text describes a protein:
Function:
Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential.
Subcellular Localization:
Mitochondrion.
Sequence:
MGGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRGYQGNGTARHFHAEERLPTPQPYPSPQDCVEATVCHVKDLENGQMREVELGWGKVLLVKDNGEFHALGHKCPHYGAPLVKGVLSRGRVRCPWHGACFNIGTGDLEDFPGLDSLHKFQVKIEKEKVTVRASKQALQLQRRTKVMAKCISPSAGHSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRAKLSKSLDAQPEQLALRPKEFFRAYGIEMLTEAQVVTVDVRNKKVVFKDGFKLEYSKLLLAPGSSPKTLTCKGKDIENVFTIRTPEDANRVLRLARGRNAVVVGAGFLGMEVAAYLTEKAHSVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRAQEGKLQEVVLKSSKVLRADVCVVGIGAVPATGFLRQSGIGLDSRGFIPVNKMMQTNIPGVFAAGDAVTFPLAWRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEINTVPYLWTAMFGKSLRYAGYGEGFDDVIIQGDLEELKFVAFYTKGDEVIAVASMNYDPIVSKVAEVLASGRAIRKREVELFMLHSKTGDMSWLTGKGS
The following text describes a protein:
Function:
Exhibits histone deacetylase (HDAC) enhancer properties. May play a role in cell cycle progression and wound repair of bronchial epithelial cells.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein. Cytoplasm.
Sequence:
MDLAANEISIYDKLSETVDLVRQTGHQCGMSEKAIEKFIRQLLEKNEPQRGPPQYPLLIAMYKVLLTLGLILFTAYFVIQPFSSLAPEPVLSGAHTWRSLIHHIRLVSLPITKKYMPENKGVPLQGREEDKPFPDFDPWSSNNCEQNESEPIPANCTVCAQILPLKVTLPEDTPKNFERLRPLVIKTGQPLLSAEIQSFSCQYPEVTEGFTEGVLTKWWRCFPERWFPFPYPWRRPLNRSQILRELFPVFTQLPFPKDASLNKCFLIQPEPVVGSKMHEVHDLFTIGSGEAMLQLIPPFQCRRHCQSVAMPIESGDIGYAGAAHWKVYIVARGVQPLVICDGTTLSEL
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Sequence:
MAEVSAAAAPVPEGVLHRRIEFHAARRPHAAAAVGGGGFQMETLNPDAAGGAATAAAGAARGEAEARRPEKAEALGLDPELTVARIYLGRIGAGLQNLGNTCYLNSVLQCLTYTEPFAAYLQSGRHKSSCRTAGFCALCALQNHVKTALQSTGKIVTPSQIVKNLRCISRSFRNSRQEDAHELMVNLLESMHKCCLPSGVPSESASAYEKSLVHRIFGGRLRSQVKCTRCSHCSNTFDPFLDLSLDIGKATTLVRALQNFTEDELLDGGQKQYQCERCRQKVVAKKRFTIDRAPNVLTVHLKRFSPFRPREKIDKKVDFQPVLDLKPFMSDSKGADYKYSLYGVLVHAGWSTQSGHYYCFVRTSSGMWHNLDDNQVRQVREADVLKQKAYMLFYVRDRIGNTLGRKDNSTPNLPVNKMIPGKISSINGVIGSGVMEAKSSGLTSSYANKKLQSTSNAHSSVSSMTLVDHCSTNAGKAETAAALQNSVLPSAQKALGPQNDGATLSTKSKQVASSSHKEASSSGQLASSNQTMAKMSLQEPKPGGALAKLGNNTSIASSMVSGPAGLSETDKQTSCSQTCSKPSSNLVGTITGFTAQTFQTKDAVLSNGVIPSTSGGDPVSSEKMKDLTGSLKQDDHVVKALTMSKKEKTILPGLEQVDVGKQISSQVSTKVVPGDSCNGRMTKRVDSKSKKLVRYPVMKLWLRPRQLSLKQQKKRKKTKKRVKGTPSVDCSGDNSSEQQTSTSATVPPKTAASTSRKRKHAHASASSENDTQAFKDRQQAVGASNAGAGDDNMTRNRESGTSARAEPPKLGSISSTDKAHSRNNVDAKRGAASQQVVIRTEDLRAEVTVPCWDDVAVPNSETREYKSSGKKSIGYVLDEWDEEYDRGKAKKVRKAKEDEDDDGMNPFQAEANYVSARKTKQNSYKSKPWDKPARPSR
The following text describes a protein:
Function:
Catalyzes the transfer of CDP-ribitol to ribitol 5-phosphate previously attached by FKTN/fukutin of to the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). This constitutes the second step in the formation of the ribose 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein. Secreted. Cell membrane, sarcolemma. Rough endoplasmic reticulum. Cytoplasm. Note=The N-terminal hydrophobic domain is cleaved after translocation to the Golgi apparatus and the protein is secreted. Localization at the cell membrane may require the presence of dystroglycan. At the Golgi apparatus localizes to the middle-to-trans-cisternae. Detected in rough endoplasmic reticulum in myocytes (By similarity).
Sequence:
MRLTRCWAALAAAIILNLLVFFYVSWLQHQPRNSRARGPRRTSAIGPRVTVLIREFEAFDNAVPELVDSFLQQDPAQPVVVAADTLPYPPLALPRIPNVRLALLQPALDRPAAASRPETYVATEFVALVPDGARAESPGHLERMVEALRGSSARLVAAPVATANPARCLALNVSLREWTARYDPAPSAPRCDALDGDAVLLMRSRDLFNLSVPLARPLATSLFLQTALRGWAVQLLDLTFAAARQPPLATAHARWKAEREGRSRRAALLRSLGIRLVSWEGGRLEWFGCSKESARCFGTVAGDTPAYLYEGRWTPPCCLRALRETARYVVGVLEAAGVRYWLEGGSLLGAARHGDIIPWDYDVDLGIYLEDVGNCEQLRGAEAGSVVDERGFVWEKAVEGDFFRVQYSENNHLHVDLWPFYPRNGVMTKDTWLDHRQDVEFPEHFLQPLVPLPFAGFMAQAPNNYRRFLELKFGPGVIENPEYPNPALLSLTGG
The following text describes a protein:
Function:
Metalloprotease (By similarity). Acts together with protease sup-17 to facilitate lin-12/Notch signaling during developmental cell fate decision, including anchor cell/ventral uterine precursor cell decision. By modulating glp-1/Notch signaling, plays a role in germline development.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MKIQDRSLLIFLVLGILKSDAFNTRVKRHAPIRFQRSTRQSVVHFEFLDQEYVVDLEPNHSTFHENFKVFTQDGPQIVPRDEYIGTVREPRAGRAVLTQLEENVYIGSLYFVDDTLHLEPSYPHQLSDDLGPVVGYFESDLDLNLDLSAMPVRNQVSFRRANPFLKHRRAIAIPSDRRKDVLNVKRNRCTLKLVADYSFYSIFGKNNTGIVTKFLVNMIARVNEIYTPINWDVGKEDDISGRGRFQNMGFSIKEIKVLDRPNASDSHYNSYSRIWEVERLLREFAFAEGSKDFCLVHLVTARTFREVATLGLAYVSYKKWDETAGGICSKQETFNGRVAYINVLLSTSFANSEQSTYPLITKEIDIVVSHEYGHAWGATHDPTIDSDDPDVEECSPNDQNGGKYLMSQYAQKGYDANNVLFSPCSRKLIRDVLIGKWESCFQEEMTSFCGNGIVEDGEECDNGVDTDNEFNCCDKFCRLAVGAKCSPLNHICCTPTCQFHNSTHVCLPGDSLLCKADAVCNGFSGECPSAPPVRDGQECLEGGECLNGVCLPFCEKMSIGKKSCICEDLELSCRLCCRDYNGTCAPVPGHVYLRDGVRCSKGSCRDRKCVNEVVDNVRNYFLITFQTTGGVLEFIKTHIVVIAIIFFTLIFVGIYKIVKYGENFTEKVTHKTAGGCRSVFVKADVN
The following text describes a protein:
Function:
Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MIIEEQIEEKMIYKAIHRVKVNYQKKIDRYILYKKSRWFFNLLLMLLYAYRIQNIGGFYIVTYIYCVYQLQLLIDYFTPLGLPPVNLEDEEEDDDQFQNDFSELPTTLSNKNELNDKEFRPLLRTTSEFKVWQKSVFSVIFAYFCTYIPIWDIPVYWPFLFCYFFVIVGMSIRKYIKHMKKYGYTILDFTKKK
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MSKLQGRPEAVAKQITAVAFGFYTEEEVRAISVKQITSPVLFDNLRHPAADGLYDAALGPLDAKGSCATCGLGYYECPGHFGHIALAVPVYHPLVFPVLYKLLRATCLHCHHFKMDAKRVAQFSQRLHLIAAGRLKEALTLADIYGSADNSAKKKKGDEMEGESVEDTPPLPGVSSALVLQDAPAVDVPAVRWTSHCLAAARDVVREFLEKVPKAKCDNCSASAPALKVEGKNKIFQMPLAPKAERANAVLGIHLRSVLEGAAPVDVTMEDTAGAQAVEGDSDEEGALPLAAPAPKATPDKGKRRPQFLTSVEVREHLRRLWDSEGPLLRLIWAAEAGPVARSRAGERAARRGNEADALFLQALLVPPNKFRPTNKLGDVLFEHPQNFHLQRILTANMTLAERLRAGAGWTAAWLELQQNVSGLLDSTAAASARAAGPPGIRQQLEKKEGLFRKNMMGKRVNYACRSVISPDPYIGVAEIGIPPYFATRLTFPESVTQWNVDQLRAAVENGPDVHPGATHVENERGVLVNLAGRTAQQRAAIAKTLLSLPGAGAGTSAAREGAMQGRRAAAKAVYRHLRDGDCVLVNRQPTLHKPGLMAHSARVLRGEKTLRMHYANCSTYNADFDGDEMNVHFPQDELGRAEAAAIVSADEQYIVPTSGAPIRGLIQDHIVAAALLTSRDTFLTRSEYAHLVYAGCGPLRTVAVPGRAADGRLLCVDKVYTEADVKLLPPALVRPRPLWTGKQVVTTLLNQLTAGQPPLTLTAGTKVPADYWGRSSGETEVVLAGGELVAGVLDKAQFGKYGLVHAVQELYGAHAAGRLLSALSRLFTAFLQMHGFTCSIDDLLLTPPAEASRAERIRTAENEVGDRVHATFGGVAAKDQEVADGAAIREGVGVRLRTGGVAEGVRLDLAMTSALNPITSAVIKDCLPGGQRRPFPHNTMSLMTVTGAKGSMVNASQISALLGQQELEGRRVPRMASGKTLPCFAPFDTAPRAGGFIADRFLTGLKPQEYYFHCMAGRDGLVDTTVKTSRSGYLQRCLVKNLECLAVGYDHSVRDSDGGLVQFLYGEDGLDVTRTSHLRKLDFLARNRHAVTAQACLDGLDDAGVERLKHKKSKADPTAGTRVEEDDPREQQLTTAQDSNPPSTLGAVSESFRDALDGFLTSAAAKGAGIRGKAARGEFRRAMEARFMQSLAAPGEPVGVLAAQSIGEPSTQMTLNTFHFAGRGEANVTLGIPRLREILMTAAAKIATPVMTIPMRKGVARSEAEALARRLTRVTLAEVCSGVEVGERPLVRAGGKNSRTYRITLRFHAAKQYPAGLELSLEELAGVVREGFVGRLKAAIKAANKKGARTLGTVQVKGGDEQAGEGDDEEGGGGARRGRRKEQDEDEPEGGEEEGEDLARETARHTQNKSYDEPDEEEAAMADSARRQAEEQEGLGWGEDDDGGERPSTSNRENGEDTSTAVVPVRGKTGAAGKAKETEAEAAARVTAGDNSCSVEITVPVGSPKLMMLEIVEKVLAGVEVRHVPGIARAFVLEGEDSAGQIRLQTDGINFEGVMNYADVVDVDRITTNDVTAMLRMYGVEVARATILSEVSAVFGAYGIAVDQRHLSLIADFMTFHGAYRPCNRLGIESSPSPFLKMSFETATHFLTDATLQGQTDHLESPSARIVVGRVVEVGTGAFDLLQNVGLARPAAAPASNGS
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MDGDQRRKTTTKETEDLCNQPVSSSEFFHSFCFGFISAENIEKLRNRREKPVSEKCRDNHVVSSKLKKHVTELSHIRKSEAVDIRIQKINSSIETLKEQSKPLKKAMNTGLYSIDSDLIELVALTARETLLEIGSSAAVDPVDVGLKVADALKRINSAVKHYKPDKTDWCNEWLYDENMDEIDEIYNGIYGDSGLSENCRLASNLAVFHRCGREMQMYPSASADTNTDQEQDVYINPALYPFNVDCDFILQLVDVECAEKLKKVREKTERGSRKKETGELVKVNDKASNVQSEEVSISNELKHVSNIFRKEIKTRKTDKIPYFEFVINPESFSRTVENMFYVSYLMRDRTLFLVEENGAPYLQKPPFATEEEQKQAENRNSTHGVTSLSFEEWKLLCGGFKKTIIQPLKV
The following text describes a protein:
Function:
Protein that inhibits host translation while promoting late viral translation by ribosome shunting. Blocks host cap-dependent translation by binding to eIF4G, displacing MKNK1 from cap initiation complexes and preventing EIF4E phosphorylation. Binds to the tripartite leader sequence of viral late mRNAs and recruits host eIF4G, PABPC1/poly-A binding protein and 40S ribosomes subunits on viral mRNAs, allowing ribosome shunting and efficient translation of late viral mRNAs even though conventional translation via ribosome scanning from the cap has been shut off in the host cell. During assembly, acts as a chaperone protein that helps hexon proteins assembly into trimers.
Miscellaneous:
MISCELLANEOUS: All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
Subcellular Localization:
Host cytoplasm.
Sequence:
MAAEGERQNLLSKHLERQVKILQSICKNDSEACNLLDLGYILEKNLFAPADSRKADSGPDPQLNFFPPFLTPECLALHYPFFLTTSIPPSCKGNRSGTDTYSQFCSRSSCLEDIPDPSEWDDSLGNVSLMAELKENQKLAPLEEDSPRTTAVDESKCSSKQSYSYPALTFPPQVQKILFDYLIGESQDPNDLDSEYKLAFTDEDLPQEGQAEKTKQRETLGAVATFGAVLLSIQRLFTHPVVIKNTQESLHYTFLHGFVRMVHLLTEVNLSEFVTFHGLTHRNRLNNPVQHRQLEGADRFDYILDTIYLYLVFAWQTAMDIWSQTIDEETERNLRERVKSLKPELAGANYAEACSLVSNTVFPPLLREALVVNIPDFVNQTQLANFRLFINNKSNVPASVCPALPSDFIPLTYEESHPVLWAHVMLLRLAAFLLNHGQYVQAPDESSISLPLCDCNLCAPHRMPCYNPMLLNEILSIGKFEVRGPDTEGKGFSLTPQVFANAYMEKFYSEDFHPHQVVLYKDDKAQFKTEPTAAVIREPKLLALIRESQTRREKSILKRGGGRYLDPQTGEVLGESSHGIGEELQDGPSYGEKPSHDLPSYGKQNPVAGRGLQAAGERVRRDAGSPSQPTEQLGRRTPQRGGTGRDKRGRGRGGRSATPDPRQETAEKESLQGTRRESS
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEPKTFFWYFKPIALICKAVGIFPLQNLGAKHPKELRGPFLSFAQLYSFGVFAFNIYMIWYFSGFMFTTQNSFYLFSVVYVMIFRSIFCFVFCARHSKKLPKLIQLLDLFDRKKRPILVDPKSSYCFCYFFTWTILPIVIGFVTIAFSFYESMNVVLETMPPEMSVLQTKLSACFFGCLATWQVLPLLLYIYFAFRITYDYRILNKTMKTQCHGCCFLSEEIKYSSDFNETLEYVRQMHNLLTKAVEEMGKCYGNFMAIDQLCLIVMVIANICTFISNNGTHEIHLLAITFFNLWVVVWVLVISNEIKEAGNKVIYVLRAIVLSGVDERARIEIQTFMMQLVAQPVEVSAAGYFIIDKRQIPSVSKTFRKNRIFLFTLYTNAESYIN
The following text describes a protein:
Function:
G-protein coupled receptor (GPCR) that forms a heterodimer with daf-37 to control dauer formation and behavior. Required for the response to dauer inducing pheromones such as the ascarosides ascr#2, ascr#3 and ascr#5.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLLPSNLTTSTLMTSSSESYDADNPGLPPEPILSDYVEMFTLVLNFIVGAPLNLAAYTQLSERPTSTRLDLLKRSLNYSDLLVLFIYVPSRACWLLTYDWRGGDALCKIVKMFHTFAFQSSSNVIVCIAVDRLLSVLSPSHHSPNKALKRTKMMLIVAWIVALVISCPQLFIWKAYLALPEYNWSQCLQIWEIARMEKFNKPQVVPEFDAEFWYSILHISLVFWIPCIIIMLSYIIVISWVWINSRPSIRHTSSFSFHTGCDTVDTVLTRASEWNPLKTFSRHVNIKEPEKPMTTPRIVVSDETEVPLTQRPSISPSEASAVMRTGVHTSTSYNANLNRSRALRVSLLLVVAYIICWLPYNLISLIQFLDRDFFSSYLKHVHFCQQLIIFNSVVNPWLYGFFGPRRPSTTGAGRH
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport.
Subcellular Localization:
Cytoplasm.
Sequence:
MLLDRVTLEDIEVNLKAEDWREAIQMSARLLLERGAIKESYIDGMIQSVENNGPYIVIAKHIALAHTRPEFGVIHGGLTFATLADGVAFGSDMFDPVKLIITLAATDSESHLEVLSELAEVLMDEEKVTRLIEANSSQAFYDELTKEG
The following text describes a protein:
Function:
Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form.
Subcellular Localization:
Lysosome membrane.
Sequence:
MAAAAAGPGAWAAQEKQFPPALLSFFIYNPRFGPREGEEENKILFYHPNEVEKNEKIRNVGLCEAIVQFTRTFSPSKPAKSLHTQKNRQFFNEPEENFWMVMVVRNPIIEKQSKDGKAVVEYQEEELLDKVYSSVLQQCYSMYKLFNGTFLKAMEDGGVKLLKERLEKFFHRYLQTLHLQSCDLLDIFGGISFFPLDKMTYLKIQSFINRMEESLSVVKYTAFLYNDQLIWSGLEQDDMRILYKYLTTSLFPRHIEPELAGRDSPVRAEMPGNLQHYGRFLTGPLNLNDPEAKCRFPKIFVNTDDTYEELHLIVYKAMSAAVCFMIDASTPLTLDFCRRLDSIVGPQLTVLASDICEQFNINKRISGSEKEPQFKFIYFNHMNLAEKSTIHMRKTPSVSLTSVHPDLMKILGDINSDFTRADEDEEIIVKAMSDYWVVGKKSDQRELYVILSQKNANLIEVNEEVKKLCATQFNNIFFLD
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1.
Subcellular Localization:
Cytoplasm. Nucleus. Nucleus, nucleolus. Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Translocates to the nucleus upon cisplatin treatment. Localizes to the Golgi apparatus during interphase (By similarity).
Domain:
The POLO box domains act as phosphopeptide-binding module that recognizes and binds serine-[phosphothreonine/phosphoserine]-(proline/X) motifs. PLK3 recognizes and binds docking proteins that are already phosphorylated on these motifs, and then phosphorylates them. The POLO box domains mediate localization to the centrosome (By similarity).
Sequence:
MEPAAGFLSPRPFPRAAVPSAPPAGPGPPANASPRSEPEVLAGPRAPDPPGRLITDPLSGRTYTKGRLLGKGGFARCYEATDTESGIAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITDNMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIEQILRHDFFTKGYTPDRLPVSSCVTVPDLTPPNPARSLFAKVTKSLFGRKKNKNKNHSEDQDNVSCLAPVVSGQAPASLIETAAEDSSPRGTLASSGDGFEEGLTVATVVESALCALRNCVAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQLSSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSMGSVPRALQPQLGILRYFASYMEQHLMKGGDLPSVEEAEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEPLLVTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDQSPA
The following text describes a protein:
Function:
Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MAGVRLSLLKSIQRSIKPHATAKSCSGLLNSHARAFTCGNLLDGPKASPSMISFSSNIRLHNDAKPFNYLGHSSYARAFSSKSDDFGSIVASGVTGSGDGNGNGNDWVEKAKDVLQTSVDAVTETAKKTKDVSDEMIPHVQQFLDSNPYLKDVIVPVSLTMTGTLFAWVVMPRILRRFHTYAMQSSAKLLPVGFSNEDVPYEKSFWGALEDPARYLVTFIAFAQIAAMVAPTTIAAQYFSPTVKGAVILSLVWFLYRWKTNVITRMLSAKSFGGLDREKVLTLDKVSSVGLFAIGLMASAEACGVAVQSILTVGGVGGVATAFAARDILGNVLSGLSMQFSRPFSMGDTIKAGSVEGQVIEMGLTTTSLLNAEKFPVLVPNSLFSSQVIVNKSRAQWRAIASKIPLQIDDLDMIPQISNEIKEMLRSNTKVFLGKEAPHCYLSRVEKSFAELTIGCNLIRMGKEELYNTQQEVLLEAVKIIKKHGVSLGTTWDNSTL
The following text describes a protein:
Function:
Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MIWFWSTLLVTAIAVLSTANESSSGQEKLAVESILFVFAHPDDESMFFGPTIDYLGNQHSTRVHVLCLSNGNADGLGSVREKELVVAASKYQIDKTNVHVVSDPQLQDGMQAKWDPTDVAKHISQIIERYNIKTLITFDNKGISGHPNHIACYEGAMKIVKATPQVQVFVLESVNIFRKYISYLDTIPTLVQSQAGRNDTIIIHADRKSTQRIRDAMVRGHKSQMVWFRYGWIYLSKYMSNNVLKRAT
The following text describes a protein:
Function:
G-protein coupled receptor for flp-2 neuropeptides. May act through the G(q) alpha type of G proteins. Involved in mediating arousal from the sleep-like state called lethargus, which occurs during molting between larval and adult stages, in part by regulating touch sensitivity, and working in concert with neuropeptide pdf-1.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MESQQLMACAILVIVLVGIFGNSLSFILFSRPHMRSSSVNVLLCALSFFDFSLLTLSIPIFVIPNLDLWANDLSLSTYMAYILKLIYPINLMMQTCSVYIMVMITLERWVAVCRPLQVRVWCTPRKSRNAILVIIVSAFLYNFVRFFEYRFVVTESGALYEKWLRDPGKHRWYYVGYYTILYIVTHFLVPFSVMAFANGHVIVAMCKLSKTRQMLTRQQQREQSTTVMLLIVTFVFAICNTLPFLLNVSESIFPTLFQDESTRGLAYWLNDLSNLLVVLNSGTTFIIYFTFSEKYRQTLVFILKNGCCATVSDYNNYTAMSRTASMRISSETGGQIQRQGSKMSNSSRSSDVLLKPIYMQKRSERFSSEYNERTCKHLAPFEEHKLPKLPSEKRKKKLHKMSAVEHRGMPEITITFSEDLPDGEPDSPCQPC
The following text describes a protein:
Function:
Involved in plant growth, and promotes salt (e.g. NaCl and LiCl) and osmotic tolerance, probably via coenzyme A (CoA) and endogenous proline accumulation (Ref.3). Catalyzes the decarboxylation of 4'-phosphopantothenoylcysteine to 4'-phosphopantetheine, a key step in coenzyme A biosynthesis (By similarity). Favors seed germination and helps the onset of flowering (Ref.3). Required for roots development (Ref.3).
Miscellaneous:
MISCELLANEOUS: The cv. Suxie No.1 (SX1) is more tolerant to salt stress than the cv. Tianlong No.1 (TL1).
Subcellular Localization:
Cell membrane. Nucleus.
Sequence:
MAGSEPVSAEGESMAVDAAPRKPRILLAASGSVAAVKFANLCHCFSEWADVRAVSSSGSLHFIDRASMPKDVILYTDEDEWSSWKKLGDSVLHIELRKWADIMVIAPLSANTLGKIAGGLCDNLLTCIVRAWDYSKPFFVAPAMNTLMWNNPFTERHFISIDELGISLIPPVTKRLACGDYGNGAMAEPSTIYSTVRLFYESKAQQGRAVVTLR
The following text describes a protein:
Function:
Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis.
Miscellaneous:
MISCELLANEOUS: Mutagenesis with N-ethyl-N-nitrosourea (ENU) lead to the discovery of the Kaos phenotype. The Kaos mutation results in the conversion of Arg-528 to a stop codon. Homozygous males are oligoasthenoteratospermic and sterile.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes to the acrosome and acroplaxome in round spermatids. Localizes to the manchette during spermiogenesis. Also found in the basal body of elongating spermatids, and in primary cilia of somatic cells.
Sequence:
MAAFERNPSRWKGTRFRRGLGASRIAAQAILSLTEKQSQGRWPSFPLGLKSKGTFRSASSYLLHQLIHRSHEAEAEQEEKQQEDGESEESEESEMQNLEDKYDGILREETVAEAITGLGWSGRGTEQVYLNLNLSHCELVDISILCGYVHLQKLNLSGNRIEDLSCVSCMPYLLELNASQNKLTTFFNFKPPQNLKKVDFSSNLISEMYDLSAYHTLTQLILDNNEIEEITGLENCISLTHLSLAGNKITTIKGLGTLPIKVLSLSNNMIETITGLEELKALQNLDLSHNQISSLQGLENHDLLEVINLEDNKIKELSEIEYIENLPILRVLNLLRNPIQTKPEYWFFVIYMLLRLTELDQQKIKVEEKVFAVNKYDPPPEVVAVQDHMTHVVNSMSQPQRIWDSTLPSLDAPYPMLILTGPAACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQEVFDEMLNMGKFILTFNYGNHNYGLNRDTIEGIARDGLASCIHMELEGVRSLKYSYFEPRYILVVPMDKEKYEGYLRRKGLFSRAEIEIAVSRVDLYVKVNQKYPGYFDAVINADDMDIAYQKLSELIREYLGLTETAAKTLAPTADTKTSYLKCEDYSRKSSTVEFLDSTDRNYFTKLWAKLSSKKSPVERESLHRQHEAARQALMGKTPRDHTLLFQRGPVPIPTVSGQQYFATIDELQKTFELSDDLFKTPSGTYPETSKDSNISKRYSTYFHTCPWSKELPFQLPEGGISSRPGSAGSDEVDGALKALRVASSMQEKVAQHKRLSAITIMDPGSNTKPTLPPIPHGRR