lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation at 'Lys-27' (H3K27me3). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (By similarity). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MASSSSPERGLEALRDTDESEGEAPGPSGPRGRGGPSGAGSALRLRSLEAEMAAACVTSTAGEDLGTFSEPGSQHGDPEGGGGPDLELGHARPMMRSQRELGLTPKGGGKADQGGKGRKGGSGSPPHTKSSRKREQPNPNRSLMAQGAAGPPLPGARGSPAMPQPESSLSPRPDQSHHFDFPVGNLEAPGPTLRSSTSQGSGSTPVPEALRCAESSRAESDQSSPAGRELRQQASPRAPDDDDDGDGGPDPRGSGTPEGWVLRSGVVPFGRRSSASEVSPEEVRPEAQCTGWNLRPRPRSSASAVSPEARPKAQSAGRNLRPRPRSSASVVSPEARPKAQSAGRNLRPRPRSSASVVSPEARPEAQSAGRNLRPRATPRVPVAPSSTTRSSSDRGSSRAPRSRSRSRSCSTPRLGSDHQRSRKIKMRLDLQVDREPESEAEQEEQELESEPGPSSRPQASRSSSRFAVPGRSSLAAEDSPPRRPVRMRASSPSPPGRLYPLPKHYFEGVHSPSSSSSESSSVSSSHSPLNKAPDPGSSPPLSSLSGPNPFWLALIADLDNLDSSSPRVPGEEIEAAPHTREEEDKKCRG
The following text describes a protein:
Function:
Trans-acting factor that binds specifically to the consensus nucleotide sequence 5'-TNCGTACAA-3'.
Subcellular Localization:
Nucleus.
Domain:
The SBP-type zinc finger is required for the binding to DNA.
Sequence:
MDWNFKLSSGYLSGFDQEPDLSPMDGSISFGGSSQSKADFSFDLKLGRNIGNSSSVFGDTEQVISLSKWKDSALAKPEGSRSSSSKRTRGNGVGTNQMPICLVDGCDSDFSNCREYHKRHKVCDVHSKTPVVTINGHKQRFCQQCSRFHALEEFDEGKRSCRKRLDGHNRRRRKPQPEHIGRPANFFTGFQGSKLLEFSGGSHVFPTTSVLNPSWGNSLVSVAVAANGSSYGQSQSYVVGSSPAKTGIMFPISSSPNSTRSIAKQFPFLQEEESSRTASLCERMTSCIHDSDCALSLLSSSSSSVPHLLQPPLSLSQEAVETVFYGSGLFENASAVSDGSVISGNEAVRLPQTFPFHWE
The following text describes a protein:
Function:
Possible component of hydrogenase 4.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MDALQLLTWSLILYLFASLASLFLLGLDRLAIKLSGITSLVGGVIGIISGITQLHAGVTLVARFAPPFEFADLTLRMDSLSAFMVLVISLLVVVCSLYSLTYMREYEGKGAAAMGFFMNIFIASMVALLVMDNAFWFIVLFEMMSLSSWFLVIARQDKTSINAGMLYFFIAHAGSVLIMIAFLLMGRESGSLDFASFRTLSLSPGLASAVFLLAFFGFGAKAGMMPLHSWLPRAHPAAPSHASALMSGVMVKIGIFGILKVAMDLLAQTGLPLWWGILVMAIGAISALLGVLYALAEQDIKRLLAWSTVENVGIILLAVGVAMVGLSLHDPLLTVVGLLGALFHLLNHALFKGLLFLGAGAIISRLHTHDMEKMGALAKRMPWTAAACLIGCLAISAIPPLNGFISEWYTWQSLFSLSRVEAVALQLAGPIAMVMLAVTGGLAVMCFVKMYGITFCGAPRSTHAEEAQEVPNTMIVAMLLLAALCVLIALSASWLAPKIMHIAHAFTNTPPATVASGIALVPGTFHTQVTPSLLLLLLLAMPLLPGLYWLWCRSRRAAFRRTGDAWACGYGWENAMAPSGNGVMQPLRVVFSALFRLRQQLDPTLRLNKGLAHVTARAQSTEPFWDERVIRPIVSATQRLAKEIQHLQSGDFRLYCLYVVAALVVLLIAIAV
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is involved in chromosome segregation and spindle checkpoint activity.
Miscellaneous:
MISCELLANEOUS: Present with 3280 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Sequence:
MASIDAFSDLERRMDGFQKDVAQVLARQQNHARQQLQQFQAEMRQLHNQHQHLIDELQRLATQRTALQQQIHAAQQATNTTREQWRSYHERESELSRRQSTLAAQSRELDSLLQQRGKECVQLRARWAAQSGNDAAEVALYERLLQLRVLPGASDVHDVRFVFGDDSRCWIEVAMHGDHVIGNSHPALDPKSRATLEHVLTVQGDLAAFLVVARDMLLASL
The following text describes a protein:
Function:
Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
Subcellular Localization:
Mitochondrion. Plastid, chloroplast.
Sequence:
MENCGKRTIVSDDATGCSKRVAVIGAGVSGLAAAYKLKIHGLNVTVFEAKGKAGGKLQSVSQNGLVWDEGANTMTESEGDVTFLLDSLGLRDKQQFPLSQNKRYIARNGTPVLIPSNPIDLIKSNFLSTGSKLKMLLEPFLWKNNKLAKVSDKHESVGGFFERHFGKEVVDYLIDPFVAGTCGGDPDSLSMHHSFPELWNLEKRFGSVIVGAIRSKLSPKKEKKQGPPKSSVNKKRQRGSFSFLGGMQTLTDAICKDLKEDELRLNSRVLELSCSCSGDSAMDSWSIFSASPHKRQAEEESFDAVIMTAPLCDIKSMKISKRGNPFLLNFIPEVDYVPVSVVITTFKRENVKHPLEGFGVLVPSKEQKHGLKTLGTLFSSMMFPDRAPSNVYLYTTFVGGSRNRELAKASRTELKDIVTSDLKQLLGAEGEPTYVNHVYWSKAFPLYGHNYDSVLDAIDKMEKNLPGLFYAGNHKGGLSVGKALSSGCNAADLVISYLESMTTDTKNH
The following text describes a protein:
Function:
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
Subcellular Localization:
Cytoplasm.
Sequence:
MIIIGGSATNGIDESLSKILSIPLVKVENKIFPDGESYIRVPSSIRDEEVLLVQTTDYPQDKHLIELFLIAETIRDLGAKKLTAIVPYLAYSRQDRRFKDGEAISIKTILHILSEVGVNTLVVVEPHKPEELSYFKGELKIVHPYHQIARKIKEIIEDPFILAPDRGALDRARKIAEEINAPYSYIEKERDRTTGEVRIKEAPNINLKGKDVVIIDDIISTGGTIVQATRLAYSLGAKSVTAAAIHLLLVGGAKERLREVGVKTLIGTNTINVNDKDIITIDVSQSIALSL
The following text describes a protein:
Function:
Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.
Subcellular Localization:
Nucleus speckle.
Sequence:
MFNNWNRPGGPGPGGPGERPPMMPGNGMPNRPPFYGPGSGPGAGGRPMHMSGPPGPGPGSHHMGMRMDSMNPRGPMSGPGHWHGPGMNMMGPGGPGPRRPPPPMTMSMMHGPGPGGPRPRMGMPIPEPVRVLVNQAQAADTAVPQPPQNEDVKLRGLQDQALHWQATAPVRKEEETVQKQAAAQDQWQSYQQQMQSYQQQYQQWYQSQETTLMDVKLKDLQEKKATCEKQLTDWKNQFDNWVEQHKKHPNKDQFDQYQNQWKTWQTQMESMVNSLDMQIKIKETSLQKNSSKNASTTQTPASVGSGVGTVTTQGANVAMPSGGHGMVPSSGAGMGQGSSIGSIPSSQSVATVPSGSGMGAGPRGLGVGPMPTGSGMGPGPSGTNPRVTPALPQGPGQGPRMESGSRSNSGAGLPGPKGQMPGKDSFPFPFPDDFPFPGDMDNFSFPDMNKLDAMFSGGFKSDEFPFSFPDFPMPGGLMGPDFPLPEGLKPEDMTKDMEEFMKQMESELGNVSAKFQPTPRGSNIADQDKQQALNAKASRGPVDIERGPQGMNRDSAGMGRHPMGMDRGPQGMERHSQEFNRGLSGIDRGPRESLQGRERVPPGMDRGQQGMDRCPPGMDRRRPGMDGGPLGMDRGQPGMDRGQPGMDRGPLGMDRGQPEMDRGPLGMDRGQPGIDGGPLGMNRGQPGMDRGTPGMDRGPPGMDRGPTGMDRGQPSLDRGPPGMDRGQQGMDRGQPGMDRGQPGMDRGQPGMDRGPPGMDRGQQRMDRGQQGMDRGYPGMDRGQTGMDRGPPGMDRGQQGMERVPPGTDKRLPGMDRGPPGMDGGPPRLDRGQPGMDKGPPGMNRGPPGMDGGPPGMDRGHPGMDKGPPGMDRGPPGMERGPPGLDRGHPGMDKGPPGMESGHPGIDKGPPGMDRGTAGRNRGQSEMDRGSSRNEGDAPRTNKVQLGIGGILAGLKDSSGMDNDHRMIDRGPPGIDSGPPGADSGPPGVDSGALRTDRSQLALGNVLAGLRAAPPGMDRGPPGIDGGPPGIDSGPPGIEINAPGRTKSQLGLGSILAALKTGPPGMDTGPPGVEMRPSGMDKGPPGIDIAPPVMDMGPPGTDRGPPSNYIKPPGMDNSPPVMGTLPMSLTRGPPGPPGVDVGPPGVDVGPPGVDIDAISMHSHYLGAGKPRPPFDQRQLDIGPPGVDTFPPGIPRYPFGSTQGPAGFGNSSSIQDSSFEEPMPPGMEPISKPLAFPRDLAPPGMDETFPPGMEPEQESQPSTKSKQPQPPEDNISEFEKGQNKPLFPPPSKGLTQHSYSVGQSIPITGMVKDSFGASSFVSTKQTLAPSPLAGYESLESVKAKKEEKKKDESKSEDKKKGKGKKGNMNMPTIIKFGDSKIDKDSDDPVKVEKDETSTDEKAAKEAAKAKEFKKENSPSEEVSKRVTVRSTLPLITDSTTKSMIPSSIGELFKKNSTTPPAFNKDVKTSLRSYRKAAEDDEEEEEAPHSKKMNRKDSSDRDDRGRDDTLRTTLPSPPRSYRSPDRRSRRSPERRRSRSPDKRKRRSRSRSISQDRRKRRRDSPPRKRNSYSPSKRRSPSKSKNSRSPSRDKGNRSPDRRDQRDRRDQRDQRDQRDRRDGRDDRYREKDRRDRYPDKEYEKDSDRRGGKPSTEAFDKLRELIYDTLVRHPDEKPRDSPHSDRRHPDDRSPQRPRRENYYPEAERPRMRYPPPRRDYERDPLRDRLRSLPRDSPRDLPLPAQREPRRDFDRDSSQDRSMERAHSPPVTEITAPIVFDYGHAESTRPAYDIETRDPMGSLLSNAVIVDVVDYSHGQNQGPDARAISGSELLQERESSFPSEFQIHKEIQPAKRDDTSMQQSPAPPHREPSPQPPPQPPMQQSLPQQTQQQELPYREQHQQFSQQYLPDDLTQQFDPYSGQQQIGYYQQPESQMAFQQQQHLQAFQQMGQFPQQAQYNTQQQQQHYTEQFEQQQQQPPPPPPPPSEDLRSSAYRKSPPPPPPDTPAPPKDDSFQQSWAAAPPPPPSDSYTSTRQSGGQDQDRSRERGDDRQRGRGDKQSGGQDQDRSRERGDDRQRGRGDKYQSGPARLVEDYRDSPGQKDMFTNSPQQTPPPPSKPKKREVVAVTDLLDPPNREKRPAKICMILRGPPGSGKSYIAKLIKDREIQNRGPSPRMLCLDDYFMSEKEKTEKDAETGKIVKKRFQEYEHEDSMEAIYHVSLLKTFKKTIEDGFFDFIIVDAVNDKISKIEPFWSYAKMKGFEVYVAELLVELGLCIQRDIHNRGETGIRKIIEHWEFAPRKYIKLDVVALLQDAAIPEVEMEELDEDAGPSMEELMNQQQEALEELEDQEETLALTKSKWDSATEEKLDALDGIKKYKKKESYTSMEDFLSCGDEFDTVSKPILPGQKRVRWADIEERQNQERMRAVGFVVGQTATDWAKITDDNYADKALNRTKYI
The following text describes a protein:
Function:
One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase.
Subcellular Localization:
Cytoplasm.
Sequence:
MSNGIVIIGSGFAARQLVKNIRKQDATIPLTLIAADSMDEYNKPDLSHVISQGQRADDLTRQTAGEFAEQFNLHLFPQTWVTDIDAEARVVKSQNNQWQYDKLVLATGASAFVPPVPGRELMLTLNSQQEYRACETQLRDARRVLIVGGGLIGSELAMDFCRAGKAVTLIDNAASILASLMPPEVSSRLQHRLTEMGVHLLLKSQLQGLEKTDSGIQATLDRQRNIEVDAVIAATGLRPETALARRAGLTINRGVCVDSYLQTSNTDIYALGDCAEINGQVLPFLQPIQLSAMVLAKNLLGNNTPLKLPAMLVKIKTPELPLHLAGETQRQDLRWQINTERQGMVARGVDDADQLRAFVVSEDRMKEAFGLLKTLPM
The following text describes a protein:
Function:
Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (By similarity). Involved in the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells.
Subcellular Localization:
Secreted.
Sequence:
MACGGKRLLFLALAWVLLAHLCSQAEAASNYDCCLSYIQTPLPSRAIVGFTRQMADEACDINAIIFHTKKRKSVCADPKQNWVKRAVNLLSLRVKKM
The following text describes a protein:
Function:
Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MRRPPPLGPTTASGPEGNVRNLQKRQAPGPGAAGGCGPEAGGRRENKQKRRMVARATPGRGEVESDKSVAASGAGKAARRRVEGRRGQVSPSDSSDPRGLEAAKEAELPLQTERHTKEKRKVTEASSDDPQPGLDLVRKESLTSSESFQTVECLQSLGKESIIEGIKRRIRNKKLKSLENPPLKITENEATQNIKVEFQDELYKNTPKYSCNILSPEVENNSVLKLRDCNCFPHSKGCNDENNLPYKPDGGCMHVAENFSKKENLRSLAEKSDTNSIPQLLQTEENVMEVNKLLPEESDLYQSKTNGLLSCLQHEKNKYSIEESSVGRKPRKRMKLSEKADETVTEMNFSNEYNKSELMLQENQMIADGKEAETKSPLNVLRKVSHNTVSLMDHLLSVPETVEKETSSEHHVNAVFQKTIEPLLKEETESTSEPLGYESMASKEDFKSMKSFIGKSPNEYHIERRSSREDLRSASEELNLSCQRTIPMTGKRTWPCYSCARISAWCWKKASLPESSYFFPGSQESYRQVDVPKHQTNQTHLTDSKLLLQSSLTETNTESSSKEKLDSNSNCLSSVSAVEPTLMVIKEPIIKDDKKIKSEELSRSGSEVISNTTEDTQLTSETQSLTGNKKKARGNLMKLNLTATSKDGQEANNSAGKTIHRKACIAQQTFIVPDLVKILNTGRLTNFKIPLLKNKTEKRKEVNAKSSEREAYSPLELLDNLSGADIRQNRSKENVSMTMLGPQTLSIRNSVTPVQASSDSFYNKKSYSISPSFTKQGNNSKPSNHVSEPGNIVSNKEVASLTVENNAFSCDPGYVEKSPSFCCNEQETFRPVSSEVRGRKITKNFSEVGFPDILKAYEDDILLIDVIQDDPDLFGVSNEGELSFTSEVPKISQEEPNVAGEHQSTDSKYMETPVKKEPSDDLRELPVLDCGWIKPDICASNSAESEIKHDPKDVNTSLGEVANETSENETLGDFSEQIKGSDLDEKHRFTDKVITKEEKENIYEVCKSKDSRNADIMVGECQFAVPVPKPLCLLVPPLNLSGRQEDTILNTWMNVFQKSLGLMIPYKYCKFHFNTLRGCERPLCKFAHVPEQGDEKVCMDVFKKYININELCLLQRAVNIFMEYYRKFPPGVYFDLQVLNDLLNSLLKHCLLKEVFQIVNLSIMVKMLPSLKILLNIFEYVATMKLRNAVPALIDIFCKLVEAGMVLDPEHFNYIVKLLYQVQASKQEITAVLEMKSRLQMRQFKKNWKCDLHSALNKLEHCKEKGDWTKLGKLYINVKMGCEKFADFQTFCACIAETLTKNYEDERPDIPFCEFAETVSKDPQNSKVDKGVLGRIGISAMYFYHKLLQWSKGRKVLEKLYELKIHFTSLKGLIGPEKLASRCQIVNVAAEIFLKSGSLDGAIWVMRESEWIINTPLWPCDRLDVLNRHNLLCTIAHEILAKSLYRQTFEVLQNLPGFQNSQETVEVSQYSLLFNKLLGSCIESSSLGMSSSVAEFMISKSIPIDFSFLRRLITSLGRSCLWLKARAHYKSALSLGCYPPLEGNLYRKLLLIPSYLSEIEMLLAIEIFMVSNASSIQSPGTSTQILQIVLKRCEDNQSRSSDDYQAAVERLIMAARISDPKLFVKHMTVNVNKEQVYSLEHCSALKWLKENMKWAGKVWLFSNH
The following text describes a protein:
Function:
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEDSHKSNTSETAPQSGSTVQAAHISHIAQQVSSLSESEESQDSSDSIGSSQKTHGILARRPSYRKILKDLSSEDIRGRKGDGENPGVSAVTSMSVPTPIYQTSTGQYIAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTSKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLYSNKSV
The following text describes a protein:
Function:
Catalyzes the acetylation of serine by acetyl-CoA to produce O-acetylserine (OAS).
Subcellular Localization:
Cytoplasm.
Sequence:
MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHALYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVFQGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFSTVVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK
The following text describes a protein:
Function:
Plays a role in intracellular enveloped virus (IEV) transport to the cell surface through microtubule transport. Together with protein OPG064/E2, forms a complex that interacts with host KLC2 (kinesin light chain isoform 2) to engage the kinesin-1 complex and thereby promote IEV trafficking.
Subcellular Localization:
Virion membrane. Host endosome. Note=Associates with the membrane of IEV particles, but not intracellular mature virus (IMV), cell-associated enveloped virus (CEV) or EEV. Colocalizes with microtubules.
Sequence:
MLNRVQILMKTANNYETIEILRNYLRLYIILARNEEGRGILIYDDNIDSIMSMMNITRLEVIGLTTHCTKLRSSPPIPMSRLFMDEIDHESYYSPKTSDYPLIDIIRKRSHEQGDIALALEQYGIENTDSISEINEWLSSKGLACYRFVKFNDYRKQMYRKFSRCTIVDSMIIGHIGHHYIWIKNLETYTRPEIDVLPFDIKYISRDELWARISSSLDQTHIKTIAVSVYGAITDNGPMPYMISTYPGNTFVNFNSVKNLILNFLDWIKDIMTSTRTIILVGYMSNLFDIPLLTVYWPNNCGWKIYNNTLISSDGARVIWMDAYKFSCGLSLQDYCYHWGSKPESRPFDLIKKSDAKRNSKSLVKESMASLKSLYEAFETQSGALEVLMSPCRMFSFSRIEDMFLTSVINRVSENTGMGMYYPTNDIPSLFIESSICLDYIIVNNQESNKYRIKSVLDIISSKQYPAGRPNYVKNGTKGKLYIALCKVTVPTNDHIPVVYHDDDNTTTFITVLTSVDIETAIRAGYSIVELGALQWDDNIPELKHGLLDSIKMIYDLNAVTTNNLLEQLIENINFNNSSIISLFYTFAISYCRAFIYSIMETIDPVYISQFSYKELYVSSSYKDINESMSQMVKL
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular Localization:
Secreted.
Sequence:
MTFLCSNFLIIALLSFMLGCSTVASASLKVGFYTQTCPSAETIVRKAVNKAVSLNPGIAAGLIRMYFHDCFVRGCDASILLRSVPGNPPAEMDHPANNPSLRGFEVIDEAKAQIEAQCPGTVSCADIIAFAARDSTYKAGGIYYAVPAGRRDGRVSIIDEVTQNLPPPSFNAQQIAQLFARKGMSVDEMVTLSGAHSIGVSHCSSFSNRLYSFNATHAQDPSLDPNYAAFLKTKCPPPTSAAGAGGDPTTVPLDSVTPNRLDNKYYTELRGRRGLLTSDQTLMDSSLTSALVLNNVKHGAAWAKKFGKAMVHMGSLDVITGAQGEIRRICSVPN
The following text describes a protein:
Function:
Mitochondrial ornithine-citrulline antiporter. Catalyzes the exchange between cytosolic ornithine and mitochondrial citrulline plus an H(+), the proton compensates the positive charge of ornithine thus leading to an electroneutral transport. Plays a crucial role in the urea cycle, by connecting the cytosolic and the intramitochondrial reactions of the urea cycle. Lysine and arginine are also transported by the antiport mechanism. In addition, catalyzes an electroneutral exchange of ornithine or lysine for H(+), a reaction driven by the pH gradient across the inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MKSNPAIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYRGLTDCCLKTYSQVGFRGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVVGLDRQAKLSDLQNAAAGSFASAFAALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVVKTVFRKDGPLGFYHGLSSTLLREVPGYFFFFGGYELSRSFFASGRSKDELGPVPLMLSGGFGGICLWLAVYPVDCIKSRIQVLSMSGKQAGFIGTFISIVKNEGVPALYSGLKPTLIRAFPANGALFLAYEYSRKLMMNQFEAY
The following text describes a protein:
Function:
Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein.
Sequence:
MNTRPILDSDKGPFVLSVSLNADNSCFSAALETGFRVFSSKTCEQMVAREVGGGIGCAEMLGTTSYIALVGGGKQPKFPQNKVCRPEDSGWELINKTDIVYEVQIWNDNTKVVTTALEFKTPVQRVRISQTHLVVVQLNKVGIYKMKVPPEKLAEYETANNPYGLCALGKGTVAFPGRAIGQVKLYDVNTGNVSIIPAHDGPLRALALSSNGEMAATASEQGTIIRLWSFPSCTKLGEFRRGVDPAAIFSLAFSPSGLTLAVTSDKSTLHIYDLHNTQTADPKKHKYGILSKVPLLPRQFSDTYPTASVKFEMGDEPTTWGPHMKSATLGAGIPGVPGGRPTKGLLGWLDDNTVLILGAGQDARWERFSIVIEEDTGKKVLAPYGWKRYLDD
The following text describes a protein:
Function:
Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly.
Subcellular Localization:
Mitochondrion.
Sequence:
MEYDSQHMQNDIHLKSRRTHACRAVLPALLSSKLPVRYLSETLKEGNLLLTDRCIKRLRDVTSGSEFLRLQVESGGCSGFQYKFTFDTEITAEDRVFGDNGARVVVDEHSLQLVTGSTVEYSEELIRSSFQLIKNPQAAQGCSCGASFSIKL
The following text describes a protein:
Function:
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Miscellaneous:
MISCELLANEOUS: Inhibited by the drug zileuton in vitro.
Sequence:
MTGSTHNGGSRLIQYEDSSNKEFIRKYLVETRNEFIEKQMRALYECREIYKDDIDEVINILTYALENNDSVLLRHEVAYVIGQISNEKCNDILIKLLNDTEENLMVRHEAAEGLAAIGSDSNIEVIKKFLNDEKVEVRETCELALSSLLEKNKYAVCSCSNKDSIKEAIKKKRNDEFVSKKFNTIDPVVFTSSGNAKSVDALIEDLNNEAVPLKLRYEALFKLRDMETDVSINALGEVLIKDKKSAIFRHEVAFVLGQALHLNSLKYLISSLQNVGEHEMVRHEVALALGSLGSLNINSQEYKNVQSEIISTLKTFSKDACRVVAESCLVGLDYIAENLNMAIEVN
The following text describes a protein:
Function:
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (By similarity). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity).
Subcellular Localization:
Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.
Domain:
The SH3 domain mediates interaction with CLNK (By similarity). The SH3 domain also mediates interaction with RALGPS1 (By similarity).
Sequence:
MAGAASPCANGCGPSAPSDAEVVHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIRGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRTSDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRAGERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSIWNSQLDEVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASGSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAVRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFLAGGHCGYVLQPSVMRDEAFDPFDKSSLRGLEPCAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSIKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEGLELASLLVKIDVFPAKQENGDLSPFGGASLRERSCDASGPLFHGRAREGSFEARYQQPFEDFRISQEHLADHFDGRDRRTPRRTRVNGDNRL
The following text describes a protein:
Function:
Possible role in vesicle-mediated transport. May be involved in proper membrane localization of Rab GTPases (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAHEIEIDSEADLGRTTFEAEDLYKQRTPITKPPAPRLQSRRASMQETPWTIKDSFNVETKDVVQRCIHTLIPTVNFFDVVDDRPDLYGPFWITTTVIQALFFSNSITEYARYATGHGTSGYSIKKLISAASIIYGYTTIIAVLLWGILVWNKCNPKLLDCLCLYGYANIVWLPVSLATPPFGLLSTLASHIVKYVLTGIGLLISIVFLTRNLYPICQQAGSNLCKLLLFGIIVFHCLLALSLQLIFFS
The following text describes a protein:
Function:
Carboxylate--CoA ligase that may use 4-coumarate as substrate. Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioester.
Domain:
Both substrate-binding domains (SBD1 and SBD2) are involved in the substrate recognition, and are sufficient to confer the substrate specificity.
Sequence:
METELHLAAGYCAATGVYRSGHPPQFAAAAALSFPEYILPHMLLPGRRARPAFVDASTGAALSFAGLRALSLRVARALAAAGLRRGRVALLLSPNSLHFPALSLAVLSLGAVLSAANPLLTPDELARQADDAKPFLALVTGELAPKLRSIAPDVKLVLVEQLLADVAAEVDDDETLDLPAANIGRDDAALLFYSSGTTGRSKGVVSTHGNAIAMAASLERAWGGGGGGGEKPQQYDDHDEAYGCVLPMFHMFGFSSFVMGTAALGATAVVVPGRFSVEKTMAAVEEYGVTRLLVVPPMVVKMVAAAAGDGEPSRRRLRLRQVVSSGAPLQREHMARFRSCFPAVNLGQCYGLTETTGIVTMCDLQHNDNGIDKVEMPPSSTDMTFVAVAATTTEVKERSTGGGGGGGGVSIGRLMPDVEAKIVDPDSGELLPPRRTGELWVRGPSTMRGYLNNEEATALALVAAAGSVSVSGGGERWLRTGDLCYVDSRGLVYVVDRVKELIKCNAYQVAPAELEDVLATHPDIHDAAVAPYPDKEAGEIPMAYVVKKQGSGHLQEDEVISFVQNKVAPYKKIRKVVFVDSIPRSPSGKILRRQLKNLLQGSILHRSRM
The following text describes a protein:
Function:
Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MANLNDSAVTNGTLHNPKTQQGKRQSTGCVKNGISKEAQQNRKAYAEDKPVFEPYQEAPLYVYVLTYMGYGIGILFGYLRDFMRNWGIEKCNAAVEREEQKDFVPLYQDFENFYKRNLYMRIRDSWSHTVCSAPEPYMNVMEKVTDDYNWTFRHTGKVIENIINMASYNYLGLAGKYDDSMVRVKDTLEKYGVGVASTRNEMGTLDIHKELEDLMAEFLNVEAVMSFGMGFATNAMNIPVFVGKGCLILSDEFNHTSVILGSRLSGAVIRPFKHNNAENLEKLLREAIIRGQPGTGRAWKKILIVVEGVYSMEGSIVNLAQIVALKKKYKAYLYIDEAHSIGCTGPTGRGVRELFGLDPEDIDVYMGTFTKSFSGSGGYIGGKKEIVDYLRMQSHSTTYATSMSPVVAAQLIRSLKITMGYEGNIGGMERIQQLKENIKYFRRRLKEMGFIIYGNDFSPVIPVLLYMPAKVSAFSRFLLKKKISVVVVGFPATSLPEGRARFSMSSAHTREMLDTVLEVVDELGDLLNVKYFPLKKSGRAILYNKEGFDNEASFEEMHSEPEA
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.
Subcellular Localization:
Secreted.
Sequence:
MVRALSVAPSLAGPLLRMHFHDCFVRGCDGSVLLDSTANNTAEKDAKPNLTLRGFGFIERVKTAVEKACSDTVSCADVLALMARDAVWPVRTYYVHTHQSMHIRTRTYVIMRISSYWLAVCSHSLRARARSGRSRWGGGTAGCPSPTRPTSCRRPRATSRSWPSFSAPRAWTPGTWRCCRPATPSARRRIASPSRTASTTSRAWTTPATPTRSWTGRTWRASAPSAPAWTTTPRWWRWTPAASGPSTWATTPTWPSAGASSTPTPSCSPTLPPAPTCSATPRVPTGTSSSPTSPRPWSRWAPSACSPAARARSGRSATSSTNLYMAS