lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transports small interfering RNAs (siRNAs) from the cytoplasm to the nucleus. Required for RNA interference (RNAi) in nuclei. Required for exogenous RNAi-induced H3K27 methylation.
Subcellular Localization:
Cytoplasm. Nucleus. Note=siRNA binding is necessary and sufficient for distribution of nrde-3 to the nucleus.
Sequence:
MDLLDKVMGEMGSKPGSTAKKPATSASSTPRTNVWGTAKKPSSQQQPPKPLFTTPGSQQGSLGGRIPKREHTDRTGPDPKRKPLGGLSVPDSFNNFGTFRVQMNAWNLDISKMDERISRIMFRATLVHTDGRRFELSLGVSAFSGDVNRQQRRQAQCLLFRAWFKRNPELFKGMTDPAIAAYDAAETIYVGCSFFDVELTEHVCHLTEADFSPQEWKIVSLISRRSGSTFEIRIKTNPPIYTRGPNALTLENRSELTRIIEAITDQCLHNEKFLLYSSGTFPTKGGDIASPDEVTLIKSGFVKTTKIVDRDGVPDAIMTVDTTKSPFYKDTSLLKFFTAKMDQLTNSGGGPRGHNGGRERRDGGGNSRKYDDRRSPRDGEIDYDERTVSHYQRQFQDERISDGMLNTLKQSLKGLDCQPIHLKDSKANRSIMIDEIHTGTADSVTFEQKLPDGEMKLTSITEYYLQRYNYRLKFPHLPLVTSKRAKCYDFYPMELMSILPGQRIKQSHMTVDIQSYMTGKMSSLPDQHIKQSKLVLTEYLKLGDQPANRQMDAFRVSLKSIQPIVTNAHWLSPPDMKFANNQLYSLNPTRGVRFQTNGKFVMPARVKSVTIINYDKEFNRNVDMFAEGLAKHCSEQGMKFDSRPNSWKKVNLGSSDRRGTKVEIEEAIRNGVTIVFGIIAEKRPDMHDILKYFEEKLGQQTIQISSETADKFMRDHGGKQTIDNVIRKLNPKCGGTNFLIDVPESVGHRVVCNNSAEMRAKLYAKTQFIGFEMSHTGARTRFDIQKVMFDGDPTVVGVAYSLKHSAQLGGFSYFQESRLHKLTNLQEKMQICLNAYEQSSSYLPETVVVYRVGSGEGDYPQIVNEVNEMKLAARKKKHGYNPKFLVICTQRNSHIRVFPEHINERGKSMEQNVKSGTCVDVPGASHGYEEFILCCQTPLIGTVKPTKYTIIVNDCRWSKNEIMNVTYHLAFAHQVSYAPPAIPNVSYAAQNLAKRGHNNYKTHTKLVDMNDYSYRIKEKHEEIISSEEVDDILMRDFIETVSNDLNAMTINGRNFWA
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MLPTVSTAVRVCVFSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLFLSLSLSLSLSLWIFDPSHGPGCESPSSSSGTGCPAQARIEDTRFLCGEYALVKSNLEDSPYIVAIERVLGSARGQDLQVEVRWFYRPEDVRAVLKRTKLNVLPNELFDSEYRQIIDPETIDGPAIIKYTAADASTTNQRRTFAGRGDTASDDEESDDEQTIPVFICRHKLLCDNHYNEPLQNPRLQRYTLSLLRRQSQLAQLDSSGATERKNAAADSEGDEDDEDHHLSAEESDAVLSAADSEDSDADVPTPRKKIAKRIAGTPKKTQTPQTADRSQPRRRGRPPAQRRTSSATGDSSPSTPAKRRASTTRGRNRRLTLRVQDTASAEPADASASSAACRALALNNLPTTNEALPCREIEFYEIYTFVQEKLHAKASGCLFVSGVPGTGKTATIRAVSRLLMAEREAGHLQPFQFLEINAMSLTSPAQAYVELYQKLGHHEDRVVAPAHACQMLQRHFTLPAPNKTTYVVLLDEVDYLYTKKQDVLYSLFDWPTHKHSRLILVAVANTMDLPERVMAHRVSSRLGLSRLSFAPYTREQLVQILKQRVAEVAAFEEPALELAARKVAAVSGDARRLAKLTLASAFVSNPIFSALGICTRAAEMAKERGAEKINIMCVSDALVELSASPILNAIQQASVYEKVSLLAALICFHQRGIEEADFADVLLQHTKLCNRFGMIPASSSVVAAVCSNLGASRVLMLEHGRYDMQRRARLNCSKDDVLFALRDDPMTQAVVQLLEAATTTRNAAPTVPQFDPEDNGDM
The following text describes a protein:
Function:
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.
Sequence:
MTITITQVYNNNITLTPSQFQSPIHDASKMVPQLFPPRHVYFPSNPSHTSTVILLHDTNSTGAELAAALDVSTTPATETATAGNPKSIFEHFPSCRWVFPSAQPRQIDICYASRGNWINVDVDVAVAVDTDANEDTDPGANSLQQPQPQLSPSTKDVDNNYNNNADQNDDLETCVEYILQVVEEEIIRLDGDSRRVVLGGFGQGMAVAIAALLAAQRRLGGFVGVSGWVPHPERIGSLAGRGRGLLVENEARMGASEGSAGADGVEVDPGADSMLETPVLLSYLEDDPCVDIQTALTVDETLNRLGFVKVVWDACPSSPQGEGSLLHLHQLDTIMGFLTEVFDHEGSNLPQDDMLGYST
The following text describes a protein:
Function:
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
Sequence:
MSPPPHSIPLYLVNGVATVWDAQTAATLHCVHNVSGLRAGTLPGVAQQNGFLGLPLTLMQEETAYLVTQGIAHLVPLDPSPSPPSDETVKAHTAARVARLKALEEKTREAEAKRLEESKKAFDKGGEKARLKREARARAKAEKAKESGEGLFAEDVKENVTAPIVVSPAKTKTKHAGAPAAGHFHIVPSHPVLSQHPPESQSITSLPHPLFPFPTTPRQCALLGVFSKLQSLSYRVGLGPRFGGEWLIYPGDYLRYHAHFTSQVIVRDEPIRPTEIVAWGRLGTGTKKAGLICCWDDGKREDGQDDQGGKEEDVEFYSLEWANFG
The following text describes a protein:
Function:
Component of the TRAPP I and TRAPP II complexes. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II seems to play a role in intra-Golgi transport. Has a role late in meiosis following DNA replication (By similarity).
Subcellular Localization:
Golgi apparatus, cis-Golgi network.
Sequence:
MDIATNFITRSLSEIAPNASQSSLHVTPSSVSNNAFGLKLRQLISDTYCPHIFIMASDDTENFMKRKGFDDFASFIRPFGDRIFQSSTNNSAISKETLDSRIFDNDHDSIRFVPMEAVQVPRQWKRNKAWNTENGLENCANSRFAPGGDIDSFRVLSQKLIEEWVQSGSNNYPENGFLNPILDYLKLLLSGNPVAEHETFSHPVGCLIVITSHNTNPMATVMRLFKEINNAPFPNFISKEILHYYLFIHDEDNNDLSNSKQIFQQMRRSLGANSHFIRLRSNYISAKPLDTDRYDTSSIQSLKNAPRDSMESESFCSSSDDAKPITFVTKNLRKFPIPEWRSSLEVQAESEQSCLPLYPLLPVEEVEGMKKFVQTMLYDSIYPFMQRCVRAWEEDLTPQYGNLTTRLLFASKKYWSRNHSSHSQGNYDPLSLIYSSEKQESIKRKMADFSFMLRDYKRAYEIYDEIRNTFSQDKAWNYLASCEEIQIICLLMQNRNISLKSQISYLNKWFDEMVYIYAVRLHSFYYTFRSVLVTSLLLSLKPAFSIDFAASWLAKILEPGPISLNPFETSFLNTTIAGMYSNKEHVGVTDGNRRRKAAFWFAYSAGFWRDCGHCKMAEICWNLANRVYSKSGWESLSEHMLDLKPTLSENFRVKNTFH
The following text describes a protein:
Function:
Ubiquitin-binding protein involved in protein ubiquitination, sorting and degradation. Acts as a ubiquitinated substrate-recruiting adapter for chaperone ATPase CDC48 by binding mono- or polyubiquitin chains. Depending on the context, promotes or prevents proteasomal degradation of ubiquitinated proteins. Involved in the ubiquitin fusion degradation (UFD) pathway by promoting the degradation of ubiquitinated proteins. Involved in the mitochondria-associated degradation pathway (MAD) by promoting the degradation of several ubiquitinated membrane proteins. By competing with UFD2 to bind CDC48, prevents the multi-ubiquitination and subsequent degradation of UFD2-dependent substrates. Required for ribophagy, a process which relocalizes ribosomal particles into the vacuole for degradation in response to starvation. Involved in the ubiquitin-mediated sorting of membrane proteins into multivesicular bodies (MVBs). In addition, plays an essential role in maintaining cellular ubiquitin levels. May affect indirectly the degradation of ubiquitinylated proteins by regulating cellular ubiquitin levels.
Miscellaneous:
MISCELLANEOUS: Present with 6800 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Predominantly localizes to the cytoplasm. Probably localizes to endosomes and mitochondria in a transient manner.
Domain:
The WD repeats mediate interaction with ubiquitin; The PUL domain is composed of 6 armadillo-like repeats and mediates the interaction with CDC48 C-terminus; The PFU domain mediates interaction with ubiquitin.
Sequence:
MGYQLSATLKGHDQDVRDVVAVDDSKVASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDSEKELLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLSFQDGVVISGSWDKTAKVWKEGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKTIKLWQNDKVIKTFSGIHNDVVRHLAVVDDGHFISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGDIVSCGEDRTVRIWSKENGSLKQVITLPAISIWSVDCMSNGDIIVGSSDNLVRIFSQEKSRWASEDEINELSTQVEKSTISSKTIEFDESKLSPYEILQSPGRKEGQIVVVKSPQGTIEAHQFSNSSWKKVGDVVGAGATGNDKKIEFEGKTYDYVFDVDIEDGKPPLKLPINVSDNPYTAADNFLARYELPMSYRDQVVQFILKNTNGISLDQPNDNASSSAVSPSKTSVMKVLPVKQYLIMENYNPDTIFNGIVKINSNEKTFDDEILAQIGGALHDIDESWELLLSFANTIRSNWEIKTPAYDIVRLIVKKLPYSSDIKDYIEEGLGNKNITLTMLTVRILVNCFNNENWGVKLLESNQVYKSIFETIDTEFSQASAKQSQNLAIAVSTLIFNYSALVTKGNSDLELLPIVADAINTKYGPLEEYQECEEAAYRLTVAYGNLATVEPTLRQFANSVTWLANIKRSYGNVPRFKDIFDDLS
The following text describes a protein:
Function:
May modulate chromatin structure by regulation of nucleosome assembly/disassembly (By similarity). Homeodomain transcription factor that mediates jasmonic acid (JA)-mediated COI1-dependent and abscisic acid (ABA)-mediated PMR4-dependent resistance to infection by necrotrophic fungal pathogens (e.g. B.cinerea and P.cucumerina) and bacterial pathogens (e.g. P.syringae DC3000); this resistance involves at least callose deposition. Required for the P.fluorescens WCS417r-triggered JA-dependent induced systemic resistance (ISR) against both P.syringae DC3000 and H.arabidopsidis. Negative regulator of the ABA-dependent drought resistance.
Subcellular Localization:
Nucleus.
Sequence:
MIKAMALSSAGVVSHLHPPSFSSSSGLSVNRVLFRNRNASPCGLSLPILNPSRSVLVFARGKNRKGFVSSSSSSPKKNKKKSLDGADNGGGEEEEDPFEALFNLLEEDLKNDNSDDEEISEEELEALADELARALGVGDDVDDIDLFGSVTGDVDVDVDNDDDDNDDDDNDDDDDDSEEDERPTKLKNWQLKRLAYALKAGRRKTSIKNLAAEVCLDRAYVLELLRDPPPKLLMLSATLPDEKPPVAAPENSSPDPSPVESLSAEDVVVEPKEKVKDEAVHVMQQRWSAQKRVKKAHIETLEKVYRRSKRPTNAVVSSIVQVTNLPRKRVLKWFEDKRAEDGVPDKRAPYQAPV
The following text describes a protein:
Function:
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
Subcellular Localization:
Cytoplasm.
Sequence:
MNDTIAAIATPPGEGGIGIIRLSGPDAQSIALRIFRPVRPGRLRSHRVRYGHVIGPDGEVIDEALLTLMAAPHSFTREDVVEISCHGGALPVQLTLEAALAAGARLANPGEFTLRAFLNGRIDLSQAEATLDVIRAQTSAGLAIAQAQLGGWLAREVRAARTAILEPLAYITALIDFPEEGIEPQTVAGPIEQALATVERLLAGADQGMVLRNGARVVLVGRPNVGKSSLLNALLRVERAIVTPIPGTTRDTLEEMANLAGVPVVLIDTAGMRTSTDPVEQIGVERAAAALAGADLALLVFDSSQPFTPEDEAMLVATADRPTIIVWNKCDDPDVPPPPAPPHPKAMAVVACSARYGHGIDTLAKTIATTLLGGTLPAVGATHLVSNPRHRAALRRAAEFLRAAQETLAAGAATDLLAADLTGAANALGEITGETVGEDLLDMIFSRFCIGK
The following text describes a protein:
Function:
NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.
Subcellular Localization:
Cytoplasm. Mitochondrion. Note=Relocalizes to mitochondria after H(2)O(2) exposure.
Sequence:
MDTEQARRALVVYGSETGNAQDVAEELGRLAVRLRFDTEVAELDAVTLKQLLQFDVVLVAISTSGQGELPPNSQKFWRAIRSARLRPGCLQQMKFASFGLGDTSYPKFNWAHRKLYNRLIQLGAQPICDRGESDEQQPEGIDGAIIPWSNKLRQRLLEEYPLPEGLEPIPDDVLLDPNWILDFADQNGTSEPETDSIDVSTPTNGTTQPPTSADLPPPDLLSIPNGLTATITSNDRITPTTHWQDVRHLKLSTPPSATYIPGSTLTIYPKNFPTDVSEFLRITGWTPIADRPLHFLPTNPKSTATKPPITVDGTLTLRKLLTNHLDILSIPRRSFFAHLAHFTTDEFQRERLLEFTDPQYIDELYDYTTRPRRSILEVLQEFETVRVPWQRYKTVIKKIREGVCTRYIASLSPGTQITVTLQKGALGVTQKDVERPVVMVGPGTGVAPMRSLIYQRMMWREELGIEKPERDLLFFGCRNHEADYFFKEEWEGLRGEEKPLDVFVAFSRDQRQKVYVQDLVREQSASVYDALANKNGIVYICGSSGKMPQAVREALIEVFGNHGELSREDAEKYLVGMEKEGRYKQETW
The following text describes a protein:
Function:
Probable subunit of a chromatin-remodeling complex. Involved in DNA repair. Required for multicellular development of all organs.
Subcellular Localization:
Nucleus. Nucleus, nucleoplasm. Cytoplasm. Note=Localized in the nucleoplasm of interphase cells. However, dispersed into the cytoplasm in dividing cells at metaphase.
Sequence:
MAFVSRIRRQSDYNTYPSSIPIVIDNGASYFRIGWAGETEPRVVFRNIVQRPRHKATGETVTIVGDLDPSMMKYFDCTRSGPRSPFDSNVVYQFEIMEYILDYAFDRLGANGSGIDHPILITECACNPVQSRSKMAELLFETYGVPAVAFGVDAAFSYKYNQLHGICKKDGIVLCPGFTTTHSIPFVDGEPIYKGSSRTNIGGYHVTDYLKQLLSLKYPFHSSRFTWEKAEDLKLEHCYIAPDYASEIRLFQEGRKEAEEKTSYWQLPWIPPPTEVPPSEEEIARKAAIREKQGQRLREMAEAKRVSKINDMENQLISLRFLLKQVDQVEEDDIPTFLSDTGYASRQELESTITKVTQSLRKARGEPKNEPAEYEENPDSLNNEKYPLMNVPDDILTPEQLKDKKRQMFLKTTAEGRLRARQKRNEEELEKEKRNQLEEERRRENPESYLEELQAQYKEVLERVEQKKRLKTNGSSNGNNKSGGIGRGERLSAAQRERMRLLTTAAFDRGKGEDTFGSRDEDWQLYKLMSKDNDDDDEQPDSDEAELARLSSRLQEIDPTFVQKVEGELSQTSGEVPRVRPLTEEDYKIVIGIERFRCPEILFHPNLIGIDQVGLDEMAGTSIRRLPHDEKELEERLTSSILMTGGCSLLPGMNERLECGIRMIRPCGSPINVVRAMDPVLDAWRGASAFAANLNFLGNAFTKMDYDEKGEDWLRNYQIRYNYL
The following text describes a protein:
Function:
Oxidoreductase; part of the gene cluster that mediates the biosynthesis of viridicatumtoxin, a tetracycline-like fungal meroterpenoid with a unique, fused spirobicyclic ring system. The first step of the pathway is the production of the malonamoyl-CoA starter unit for the polyketide synthase vrtA. The aldolase vrtJ may be involved in the synthesis of the malonamate substrate for malonamoyl-CoA synthetase vrtB. The polyketide synthase vrtA then may utilize the malonamoyl-CoA starter unit, followed by sequential condensation of eight malonyl-CoA units to form the polyketide backbone. The cyclization of the last ring could be mediated by the lactamase-like protein vrtG. The proposed post-PKS tailoring steps are a hydroxylation at C5 catalyzed the cytochrome P450 monooxygenase vrtE, a hydroxylation at C12a catalyzed by VrtH and/or VrtI, and an O-methylation by the O-methyltransferase vrtF. VrtC is then proposed to catalyze the transfer of a geranyl group synthesized by vrtD to the aromatic C ring of the tetracyclic polyketide intermediate of viridicatumtoxin to yield previridicatumtoxin. Finally, the cytochrome P450 monooxygenase vrtK catalyzes the spirocyclization of the geranyl moiety of previridicatumtoxin to afford viridicatumtoxin.
Sequence:
MGARSKEARHRWFSRLPPDASSSFLPCKRPKSVAFVLWIRPSCFLRESLPAELSGLPGLPLPPQAPTNTMNCGLPEAALSVIDWGRLKSGDVNEGARLLSACDDQGFFYLDLSSEPSFLHDHKSVLHFMDQYFHQGLADKMKDDRQSDTHGYEPVATSTGALNTLPDYYESLKASRDELHGDGRNLAPAVCDRQDLFLRFSDMMHQMVIAILQELDCQLGFGGDRASFQDFHRKDAESLTTLSMFRYPKQETLDLGVGHNKHTDIGTLTFLLCDQWGLQVLSKDPAGWRFVAPREGHAVINVGDTLRFLSGNRFRSAVHRVIPTQRLQHEDRYSIAYFLRAANDTQFTDSAGRQVSAKQWHDEKFDVFRETHEEQEKMPILTGGMERLENLPGIWCGVRLTDGICHRLGAEDC
The following text describes a protein:
Function:
Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
Miscellaneous:
MISCELLANEOUS: [Isoform B-delta-S2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
[Isoform A.1]: Cell membrane; Single-pass type I membrane protein; [Isoform A.2]: Cell membrane; Single-pass type I membrane protein; [Isoform A.3]: Cell membrane; Single-pass type I membrane protein; [Isoform B]: Secreted; [Isoform B-delta-S2]: Secreted.
Sequence:
MDPKQTTLLCLVLCLGQRIQAQEGDFPMPFISAKSSPVIPLDGSVKIQCQAIREAYLTQLMIIKNSTYREIGRRLKFWNETDPEFVIDHMDANKAGRYQCQYRIGHYRFRYSDTLELVVTGLYGKPFLSADRGLVLMPGENISLTCSSAHIPFDRFSLAKEGELSLPQHQSGEHPANFSLGPVDLNVSGIYRCYGWYNRSPYLWSFPSNALELVVTDSIHQDYTTQNLIRMAVAGLVLVALLAILVENWHSHTALNKEASADVAEPSWSQQMCQPGLTFARTPSVCK
The following text describes a protein:
Function:
Involved in DNA repair and RecF pathway recombination.
Sequence:
MRLYRDRAVVLRQHKLGEADRIVTLLTRDHGLVRAVAKGVRRTRSKFGARLEPFAHIEVQLHPGRNLDIVTQVVSVDAFATDIVADYGRYTCGCAILETAERLAGEERAPAPALHRLTVGALRAVADGQRPRDLLLDAYLLRAMGIAGWAPALTECARCATPGPHRAFHIATGGSVCAHCRPAGSTTPPLGVVDLMSALYDGDWEAAEAAPQSARSHVSGLVAAHLQWHLERQLKTLPLVERFYQADRSVAERRAALIGQDIAGG
The following text describes a protein:
Function:
Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54.
Sequence:
MDQDCGIASCSKNNVDIQQDEELAELTLAQGINVWGKNQQTLEEQALEEINIFTQQNATKDVEEGEIIEDQKQEKVSSLDITSYIKRQEELRKIQEYKKTLQVKDKSKIIADKLTEKEKRGFKKRKRSASEKEPMKKKVAIEKAEGNDSGSEYVPSEGEDSDLERDYKQLRKQKNVTTKNSVEKIRDDGCLKSYKNRLKEHYKQLESEINCEEADSEIPDFYTIKGGLKIPLKIWCNLYPYQQEGVRWLWNLHRQSAGGILGDEMGLGKTVQVIAFLAGLEYSKVISFDRFKGLGPTLIVCPVTVIYQWVKHFHDWAPEFRVAILHQSGSYEGNMSNLIKEIHKDRGILVTSYGGILKYKENLAQFEWHYVILDEGHKIRNPNAKVSVAVKKFRTPHRLMLTGSPMQNNLQELWSLFDFTNPGMLGNLATFMEHFNNPIVQGGFANATPMQEATALSVATTLKTLITPYLLRRSKNEVQEHISLPNKSEQVLFCSLTEEQRELYKGFLMSDHVASILGSSKNWFAENQTRANVLISITALRKICNHPDIYLHAAGEEAEDDQNVCDKKFGYYKKSGKMIVVSALLKIWKKQKHRVLLFTQSRAMITIFEEFLKQQGYTYLKMDGSTAVSSRQPLINKFNEDSSYDVFLLTTKVGGLGVNLTGADRVIIYDPDWNPATDTQARERAWRIGQEKQVTIYRLLSAGTIEEKMYQRQVWKQLLSNKVLLDPKTRKFFKSSNLHDLFSLPENRDDSNPETTNIFRDARVKIQEQLTEKQKKKSETFQFSEDKIQAMKNRAQEIAKSIAKPQEQKTSYQIQLEEERQEKLKMKEELKQLTPLELMRLNREKAQERPESPTNKVDDCNTSVSFSKALEYSEKNAKLYHKIRKDEKRESGSKKKKSKEKDIFKTLIDNTGLVEGEKVDGLVKTEIKKLRKKHEVGKTNESQDNYVLEKLFSKKGVSGALQHDSILNSGVKTQSFRVQTEAKLRADKALEALRKSRLNSWRW
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular Localization:
Nucleus.
Domain:
The BTB/POZ domain mediates the interaction with some component of ubiquitin ligase complexes.
Sequence:
MDTIRVSKEVPGSSKSTAQSLTESTSRTETINGSHEFKISGYSLVKGMGIGKYVASDTFMVGGYSWAIYFYPDGKSPEDNSVYVSLFIALASEGADVRALFELTLVDQSGNERHKVHSHFGRTLESGPYTLKYRGSMWGYKRFFKRSLLESSDYLKDNGLLVRCCVGVVKSRTEGPRCYNIPVPVSGLGQQFGKLLESGKGADVTFEVDGETFPAHKLVLAARSAVFRAQLFGPLRSENTNCIIIEDVQAPIFKMLLHFIYWDEMPDMQDLIGTDLKWASTLVAQHLLAAADRYALERLRTICESKLCEGISINTVATTLALAEQHHCFQLKAACLKFIALPENLKAVMETDGFDYLKESCPSLLSELLEYVARLSEHSLTSSGHRKELFADGCDLNGRRVKQRLH
The following text describes a protein:
Function:
Transcription factor involved in developmental processes (By similarity). Controls the transcription of genes required for excretory canal formation.
Subcellular Localization:
Nucleus.
Domain:
The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain.
Sequence:
MSSGLPSIAATAQPSANGFSFNNGFPPFGIYYSQLPPVNSNGSTPNSSNRFKVKRHRQRVDAGEPRNTYQGASTSVSSNSSSSSSTSNTNSTPSSSSTSSKKSTEGMTETETMTASIEQEKVIQNEESEAGKDGMEEHDDGMNDFEIIDDTNDEVEESEERESPESNSSSASKRKSFQPQKIGEELGIEFGDETEQINVTVGGTEEAEETTDEAEGRELSALQAQLQNGHIAEQQRRFYAAFLDQQRKQVAAAQILHNGKINIERLVSSVKGDLVTNFMKDLEKVIRDWAADEVLKQEAAAPPQIPQPPPQFHPIFPANPLFHMAPPHHPVAGGGIFPPNFNAFNAFNALRRNLQDVDTSSEMKKKRTKVEIKKEDAMSSRASPLSASASPPLSRFFPAPTMVGHYGGMNFGDREDSPTNSDELSECGYEGGGSSSMLTPMHLRKAKLMFFYTRYPNSNLLKSYFPDIRFNKNNTAQLVKWFSNFREFYYNQMEKFARQALAEGITDRNDIFVSKDSELFKVLNTHYNRNNHIKAPDRLVFVVQETLREFHDAIKQGKDIEPSWKKTIYKVINRLEDQIPDFFKEPNFLERLET
The following text describes a protein:
Function:
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Involved in the maintenance of mitochondrial (mtDNA). Required for both repair of mitochondrial DNA and recognition of a recombinogenic signal characterized by a 26-bp palindromic at sequence in the ery region of mitochondrial DNA. May have a general role in chromosomal replication by affecting Okazaki fragment maturation. Required for the completion of S-phase.
Miscellaneous:
MISCELLANEOUS: [Isoform Nuclear]: Produced by alternative initiation at Met-40 of isoform Mitochondrial.
Subcellular Localization:
[Isoform Nuclear]: Nucleus, nucleolus. Note=Mainly concentrated in the nucleolus, and occasionally redistributes to single nuclear foci outside the nucleolus, probably sites of DNA repair; [Isoform Mitochondrial]: Mitochondrion.
Sequence:
MFSCQSLYKFSHSFRKRIPVMFQRAQQKSSLLHTQNESSHQPSLNKLGGFSSASLNFNSSRSSTNDDQQTFSSQSDNLPSSPITLPAKRGRSAASLKQLDNTVGFDVSKPSLPVFENSGLGSKYSTEIANGVYIDENDFDDDLLLENDIDQKPIPWSSSPIEHTKLTKSMLSSEKRSKNHLSKIYEDHTSEKGASSVISSNITRQGIKRSRTLPWAVDPYRYGDPDPKRTSTSADISQHTVSNDSSNKLSNGRSSSLDSLAKKRMSKSKSTPQISKKFSVPLNSASKSPIGSSLFKTSDSRKKSVPSIFLSDEQKRILDMVVEQQHSIFFTGSAGTGKSVLLRKIIEVLKSKYRKQSDRVAVTASTGLAACNIGGVTLHSFAGVGLARESVDLLVSKIKKNKKCVNRWLRTRVLIIDEVSMVDAELMDKLEEVARVIRKDSKPFGGIQLVLTGDFFQLPPVPENGKESKFCFESQTWKSALDFTIGLTHVFRQKDEEFVKMLNELRLGKLSDESVRKFKVLNRTIEYEDGLLPTELFPTRYEVERSNDMRMQQINQNPVTFTAIDSGTVRDKEFRDRLLQGCMAPATLVLKVNAQVMLIKNIDDQLVNGSLGKVIGFIDDETYQMEKKDAEMQGRNAFEYDSLDISPFDLPDVKQKKYKLIAMRKASSTAIKWPLVRFKLPNGGERTIVVQRETWNIELPNGEVQASRSQIPLILAYAISIHKAQGQTLDRVKVDLGRVFEKGQAYVALSRATTQEGLQVLNFSPAKVMAHPKVVQFYKQLASVNGLPIRNENKAPVQMRGVKNK
The following text describes a protein:
Function:
Adhesion G-protein coupled receptor (aGPCR), which is involved in oligodendrocyte development and maintenance of peripheral myelin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as RhoA pathway. Adgrg1 is coupled to G(12) and/or G(13) G proteins (gna12 and gna13, respectively) and mediates the activation Rho small GTPases. Adgrg1-dependent RhoA signaling promotes timely radial sorting of axons. Required to establish proper myelin thickness and facilitate organization of the myelin sheath in the mature peripheral nervous system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The Stachel sequence (also named stalk) in the C-terminal part of the extracellular domain (ECD) functions as a tethered agonist (By similarity). In the inactivated receptor, the Stachel sequence (also named stalk) is embedded in the GAIN-B domain, where it adopts a beta-strand conformation (By similarity). On activation, the Stachel moves into the 7 transmembrane region and adopts a twisted hook-shaped configuration that forms contacts within the receptor, leading to coupling of a G-alpha protein, which activates signaling (By similarity).
Sequence:
MKQNPAKTARMWIIICLLFVLGQATDNDRDFKMCGKWLHGIAPQNLEYDLKTGCERIEISANESTLSIQGRITAKCTQSSSIQLDSNPHQNQSHFCVFWEPLLDLLIVEVNGKNHTLCKPNGLQGTCCTDLSQGVQDNAHMYGIVNGSVKGDIITGDLKGNYIFDGAHINCKEKFCDEARLKPRGANMIEEVVMRFNAKGRVDLPCAQGTVIEMDEEFTGHNFTVPAPRFVDANTIPSVYIPSSLRSVSRRKSKVVCTYYKNKTLFERGPSKSALLDDIVGLSVENETIRNLIEPVKIRFHHRPFAPDSSGRCVSWDTKQDNEVNWKDDGCDTVKINEEQTECHCNHLTYFAILVQVEQKSTVRHLKALTFITAVGCAVSLVSCLVLFYWLCKRRRGKKNQISLVHRGLVVAIFLLCLFFILTGILANVANETVCQLTGSLLHYGLLSTLCWMAMEVFHTFLLVRKVFNSPLPIWIFYLMGFGFPFLLVSILLSVGDIYGERKIKPSDDVNNPYRMCWMTEGDKSQLAHYIINIGLLAVVVSSGLVMLFLVVREIRNRPDWKKIHVAFLSIWGLTCLYGTTWALGFLDFGPFSEVTLFLFCIINSLQGFFLMLRYYALERMKKKDVSSSDGSSSGSSKQHMLQTNEKS
The following text describes a protein:
Function:
Up-regulates the transcription of the genes for ATP-binding cassette (ABC) transporters YOR1 and PDR15, for major facilitator superfamily transporter AZR1, for pleiotropic drug resistance SNG1, for alpha-glucosidase YJL216C and for YLL056C.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDGSHFPMKSTTGEPVSSGKKGKRRKVIKSCAFCRKRKLKCSQARPMCQQCVIRKLPQCVYTEEFNYPLSNTELFEQVPNVALVQKIENLQTLLKENDNNNAKPVYCRSSENPLRSLRTSVLGDNGSRYVFGPTSWKTLSLFEQNKFQTEFQNLWKVLKPLPECTKSQLNENDVVADLPSFPQMESCIKSFFAGPLFGILHIFNQDDILSLLDRLFIRDTTDKNLVILLDLQGNAKDKYNLGIVLQILCLGYYNQDIPSSVSHFLHTLSAASLSSSSSNFVEKLQFFLLSYISVMINCTDGVWDATQGVDLINELCQGCISLGLNDIDKWYLNESEETKQNLRCIWFWALFLDVSTSYDIGNPPSISDDLLDLSIFTAQNFQSPSIDFRRVKLMHDFLDVSRFTTREIHKREMNEKLTTFSLRLIEFIQSNFSPIEHYTNSVYYSDIDPFDILILSRSLSIVASIYNIEMIIAQQSRIIDKNRMVQFLLISISVCVNTMVFHFKEPINDQENVLTEGLKLSIILINPLLIRIVSQVYSLAFNRLIFREKAFLFLIDLDTGKKIQFIKYEEENFDELLTGFDVRTDKFLSFSGTIIRFYEIIDSIFAVNERNKRLLKAVSNFYQLTSTLAFERVSRVLFDKASQARIETEKIWLKKGINMEHFSDLMIEDFINDVWKTFKEISKDLWSIDKKKFYKQYHFDL
The following text describes a protein:
Function:
Has a role in intercellular carbohydrate-mediated cell adhesion.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MLCPPMALGPFLAAPVPRPPPSASEKKRICRNLFNNAPGDSNIDQLLAQEQHTQRLYVKERYGYDIQLESNRDADANTDADADTDAHCQVLRGMRYPTSRTISSTDADECNPKAVSQAPRGMALTPAQISASAKLILQKCPESDRKKSNGSADLANCTRHGQKPYARQPQGLKGMYNVRKTVNGISKPNVKNGYNNNNNSSSSNNNSNMNINNKIVDNGTSELADQKQ
The following text describes a protein:
Function:
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
Sequence:
MDAYWIIEKNHPSEIHWHGVSRFYYTGVSPFQKIEIIESTFYGKCLVLDGRIQSSEKDEFIYHEALVHPALLLNRAANKKVLIMGGGEGATLREVLRHKDVTEAIMVDIDGEVVEVSKKYLPEWHQGAFDDPRTRLYITDAREFVEKSKEKYDVIVSDLSEPMEGSPAVKLFTFEFYHIIKDHLKEDGIFVMQAGTTHHLKIAFHSAMNSTLRRVFKIVRSYQAYVPAYDFIWSFIWASDKIDPKDFSEEEINSLLKSKNLANLKFYDGETHKMMFSLPKHLRELIEREERVAYDNAPLYAVED
The following text describes a protein:
Function:
This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
Sequence:
MSINKNIARLRRAKSTRAHIRELGVARLSVLRTGQHLYAQVFTADGSKVIAAANTLQADVKDGLKNGKNSDAAVKVGKLIAERAKAAGIEKVAFDRSGYRYHGRIKALADAAREGGLQF