lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular Localization:
Nucleus.
Sequence:
MQQRSEEYSYIWGTGIAMEVFRDEFRRYLETFALGQVVVDPSRRTLPSSGGGAAAARSSVSDTAAAAAAEYALQEKYYLKELLRMHMQGRSTLEVDFTWLQRVAPRLYVQTVHHPTECLQMMSAVADEVYRDVLLLRHGIEVAEDVLITVAAKKLPSMWTLKQLSPQHIEQLLSIKGMVIRVSKIVPEIRVACFQCWNCQYQERSVSGDKGRIFEPTRCAHCGKTYSFKLQHNLSLYEDKQLIKVQESPEHVADGETPISIGVVVYGSMVDAVVPGDRVIVTGVYRSTPIRLNANTRIIKSIFATHIDAVHIELVRATRASEAGAKKGCFANGNATGTGLHVSTPTLATAKNAEGDLSSAVLMDTARLDMFHSLAHRPDIYDVLLHSFARTIWGHDDVKRGILAQLFGGTAKTFVFSERIGSGAAATTSSNSAVFRSELNVLLCGDPGVAKSQLLTQVHEIAPRGVYTSGKGSSSVGLTAFVVQDSDTGELVLEPGALVLSDRGLCCIDEFDKMNEATRSVLHEVMEQQTLSIAKAGIIAQLNARTSILAAANPKDSQWNAQLNVVENLQIEPTLLSRFDLIFLLLDCHDSVEDRRLAAHVLSLYMDTSRSARTPRAVNSGSGAAGRRVPPQGGCSDDDSGEEGEATQWRSTARAGQPTAAPDDATGTASTHVDAATGLPVEVQMELHGEVFLQGPPDAPYMPASILSEYIALARETIFPKLTEASHKMLARCYVELRQARGSSCTVSATLRQLESMIRLSEARAKMRYGSEVSVEDVVEAKRIISAALKKAATDPTTGLINLDMFHAADPGKNTVEGNMRRLEELLKRRYLAQGRHTVSVAELRSVFNEQQSGAARPVAPAQFVEFLALLSGGDVVQSFTATTVTLAMAGAAPM
The following text describes a protein:
Function:
Protease component of the SPS-sensor system, which regulates the expression of several amino acid-metabolizing enzymes and amino acid- and peptide-permeases in response to extracellular amino acid levels by controlling the activity of two transcription factors, STP1 and STP2. Catalyzes the activation of these transcription factors, which are synthesized as latent cytoplasmic precursors, by proteolytic removal of an N-terminal inhibitory domain containing cytoplasmic retention motifs. SSY5 binds as an inactive protease complex to STP1. In response to extracellular amino acids and dependent on the other SPS-sensor components, the inhibitory propeptide is induced to dissociate, and thereby enables the catalytic domain to process STP1.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MVRFFGLNKKKNEEKENTDLPADNEQNAAETSSSNVSGNEERIDPNSHDTNPENANNDDASTTFGSSIQSSSIFSRGRMTYGTGASSSMATSEMRSHSSGHSGSKNSKNLQGFKDVGKPLRAVSFLSPVKEEESQDTQNTLDVSSSTSSTLATSENARENSFTSRRSITLEYIHKSLSELEENLVDIMDDIHQDVISISKAVIEAIEYFKEFLPTTRDRIPYRISLEKSSSLRKINKIVLHFLDNLLVSDAFSNSRSILLRRFYFFLKKLNLITDDDLISESGVLPCLSVFCIGSHCNLPSMDKLGMILDELTKMDSSIISDQEGAFIAPILRGITPKSSILTIMFGLPNLQHEHYEMIKVLYSLFPDVHMYCVKDYIKKAASAVGSIPSHTAATIDTIAPTKFQFSPPYAVSENPLELPISMSLSTETSAKITGTLGGYLFPQTGSDKKFSQFASCSFAITCAHVVLSEKQDYPNVMVPSNVLQTSYKKVLTKESDRYPDGSVEKTAFLEEVQRIDQNLNWQKSNKFGQVVWGERAIVDHRLSDFAIIKVNSSFKCQNTLGNGLKSFPDPTLRFQNLHVKRKIFKMKPGMKVFKIGASTGYTSGELNSTKLVYWADGKLQSSEFVVASPTPLFASAGDSGAWILTKLEDRLGLGLVGMLHSYDGEQRQFGLFTPIGDILERLHAVTKIQWDIDPQLDG
The following text describes a protein:
Function:
May play a role in lysosome homeostasis.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MVRILANGEIVQDDDPRVRTTTQPPRGSIPRQSFFNRGHGAPPGGPGPRQQQAGARLGAAQSPFNDLNRQLVNMGFPQWHLGNHAVEPVTSILLLFLLMMLGVRGLLLVGLVYLVSHLSQR
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm.
Sequence:
MSGSRNNRVMVEGVGARVARGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRIMDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLLIGDLVNIDLELEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANVVRSGDAAQGAEGGTSPFQVGDLVQICYDIERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDNDLKVEVCGTSWTYNPAAVSRVASVGSAISNATGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVDDLLKRQDVDVNGQCAGHTAMQAASQNGHVDILKLLLKHSVDVEAEDKDGDRAVHHAAFGDEGTVIEVLQRGGADLNARNKRRQTPLHIAVNKGHLQVVKKLLDFSCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGSANLDIQNVNQQTALHLAVERQHTQIVRLLVRAEAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDTTTWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLAVRNKKGQSPLDLCPDPNLCKTLAKCHKEKSSGQVGSHSPSMINNDSETLEECMVCSDLKRDTLFGPCGHIATCSLCSPRVKKCLLCKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCASLMKKCVQCRAVVERRVPFVMCCSGKGTEDVADDIAGGNIPALQKDKDNTNVNADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFMCGHGTCQLCGDRMSECPICRKAIERRILLYSMSC
The following text describes a protein:
Function:
Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD.
Sequence:
MTNTYYEVIDTEISIEEVTKKVIRRECGAVTTFIGTVREFTKGRRTLYLEYVAYKTMAEKMLEKIGLEVKEKWPGTHVAITHRIGTLQISDIAVVVAVSTPHRKAAYEANEYIMERIKQIVPIWKKSFGKMVTHGLVIN
The following text describes a protein:
Function:
Probably involved in the biogenesis of the COX complex.
Subcellular Localization:
Membrane. Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSKPNPFLNLFRRYYTQQTPHLARPAIRPQCLRQRFTQRRPSPSPRLQPTLLLLQRRSVGGGPGLDPNFVSILDRPAKMVRSGKQHGPGLIILAIIPLTAFILGCWQVQRLGWKTELVARFEDRLTFPPLELPLRIDESMLEAFDYRKVYARGRLRHDQEMLIGPRILDGEEGYTVVTPLERTDARGNVHKILCCRGWIKKDTAPQWFRKNSGGLPEGEVMVEGLLRIPPKGNMFTPKNEPEKGKWFFPSVEEMAQHTGSQRVWVEETMTPDLLTNYEREPKGIPIGRAPTVNLRNNHTQYIFTWYALSFATSIMFWMVVKKPMSGTQRRVRHSVEW
The following text describes a protein:
Function:
Required for selective autophagy activation by ubiquitinated proteins. Implicated in sigma rhabdovirus multiplication and necessary for male fertility. Involved in activating transcription of Drs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSLSVKAYLLQDDGNQEIRRFAVDEGVSTNYDYLVQKVQSVFPNVRGRGIRLYWKDSDEELVTFSSDEELVEALGSLNGNVFRLFIKPVGEVPIPPEGSDDSGASNAIHPGVVCDGCNVNIMGTRFKCVICPDFDLCMKCEAKGLHREHEMLRICTPRAHPHFHGPFANPPPPFGPQHFAQGFGPWKHGHRGHFWGPGRRCGGPRGHCGKGRGPRCNRHQEKAKESTEQPQPGTSAEEQGQEVPVGPPFLHNMGEALASFLGPMGVEVHTYADDEQDCCQGKCNCSHKKHGKKYPKDSSSSSSSSSSSSSSSDSENEKKAHKKGKHGKHKEERDGKTAEATDSLPMDTEHGEGYVLVDKENQSENTTEDQGGAAEGTDEAPVDPLEVAIAQMRAMGFEDDSGWLAQLIKSKEYDIGKVLDAIQFEGKK
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MEEYKAKSKLSESSTSTVWLAKHMLTGEEAVMKCFDLSKLNHNLRICLENELDFLSSVDHPNIIRLLHVLQEKDLLIMILEYCDGGTLSSYIKRHGRVQEHIARRFMKQIGAGLEIIHDNHIIHRDLKPENILLAGAGDESVLKIADFSLSSRKLLPGKYLETVCGSPFYMAPEVLQFQRYNEKADMWSVGAILFELLHGYPPFSGRNNVQVLRNIKSSLSCPFSRSIVQQLHPDCIDVCSRLLSTNPVTRLSFDEFYKHKFLSI
The following text describes a protein:
Function:
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Acts as a chaperone that specifically mediates the integration of RPS19 in state post-A1. Direct regulator of SIRT1.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSASLIRRGLELLEAPGQGKAPPALQQGRDGTRPAGTARRRKVTAGPGKNKATIKGRVVKSAIEEYHKKKAVNHLKANLLYMTSGRCVADKAVTQQVLTQNRGRKSKDRPAEKKEKKKPEGTVFTEEDFRKFEREYFGIP
The following text describes a protein:
Function:
Involved in meiotic DNA-break repair. Required for the recruitment of DCM1 to meiosis recombination hot spots.
Subcellular Localization:
Nucleus. Note=Localizes at chromosomal foci at leptotene and zigotene.
Sequence:
MNYLETQLNKKQKQIQEYESMNGNLIKMFEQLSKEKKNDETPKKISSTYIKELKEYNELRDAGLRLAQIIADEKQCKIKDVFEEIGYSMKD
The following text describes a protein:
Function:
Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues.
Subcellular Localization:
Secreted, cell wall. Secreted, extracellular space, apoplast.
Sequence:
MRAAGAAPGALHRRRGGGQGGRRAGGDVGRRPRERLARWPGADAVARPHLRLRVPLQGHVPLRARRRADQARPRQLRRHGHHLLRKLPSLLFFLGLPVSVQQRMHVRADQSATSCQRVSDDGCMQFISEGPWDVHDEVDLEFLGNASGQPYTLHTNVYASGNGSREQQFHLWFDPTADFHTYSIQWTQQHILVLVDGTPIREFKNHADRGVPYPSSQRMRLYGSLWDAEDWATQGGRVKTDWSRAPFVAQYRNFTAAPPATAAAGQYGQQMDAEAQQAMKWARDNYMVYDYCADTKRFSQGAPPECSMA
The following text describes a protein:
Function:
Accepts the ubiquitin-like protein NEDD8/RUB1 from the ECR1-AXR1 E1 complex and catalyzes its covalent attachment to other proteins.
Miscellaneous:
MISCELLANEOUS: Reduction in RCE1 levels leads to reduced organ length and defects in gravitropism; MISCELLANEOUS: [Isoform 2]: May be due to intron retention.
Sequence:
MIGLFKVKEKQREQAQNATRGGASVKKQSAGELRLHKDISELNLPSSCSISFPNGKDDLMNFEVSIKPDDGYYHNGTFVFTFQVSPVYPHEAPKVKCKTKVYHPNIDLEGNVCLNILREDWKPVLNINTVIYGLFHLFTEPNSEDPLNHDAAAVLRDNPKLFETNVRRAMTGGYVGQTFFPRCI
The following text describes a protein:
Function:
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis.
Sequence:
MDMLNTLRDTLSSVQAELSTGVEKLRMNVSANIVAQQKVSTESVNEILNTSAGNELLQNFQNLITEVEENGAEGGRLANLCSTRMGRCQQMCKEKADAVMEIDEFLRNSVEFDKKIREINAQISKLTRFCNQTEQAMTYLEALCEVAHTEGEVDLIRQQAKSAATIVQIECESPSVLTSALRSRPEDAVKAQQEEVMLEEFLSSKNMQLP
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MGGKNKQRTKGNLRPSNSGRAAELLAKEQGTVPGFIGFGTSHSDLGYVPAIQGAEEIDSLVDSDFRMVLRKLSKKDVTTKLKAMQEFGTMCTERDTEIVKGVLPYWPRIFCKISLDHDRRVREATQQAFEKLILKVKKHLAPYLKSVMGYWLMAQCDTYTPAASAAKDAFEAAFPPSKQPEAIAFCKDEITSVLQDHLIKETPDTLSDPQTVPEEEREAKFYRVVTCSLLALKKLLCLLPDNELDSLEEKFKSLLSQNKFWKYGKHSIPQIRSAYFELVSALCQRIPQLMKDEASKVSPSVLLSIDDSDPVVCPALWEAVLYTLTTIEDCWLHVNAKKSVFPKLSAMVREGGRGLATVIYPYLLPFISKLPQSITDPKLDFFKNFLTSLVAGLSTERTKTSVSECSAIISAFFECLRFIMQQNLGEEEIEDMLVNDQLIPFIDEVLKDPRLQDGQLFNHLADTLSSWEAKADLEKDDKIAHNLEKVLLNFWERLSEICVEKISEPEANVKSVLGISNLLQILQKPKSSLKLNRKKVGKVRFADEMPESNKENEKCVSSEGENSEGSELMAEPSLTQNCSDLISPLRKKPLEDLVCKLAEMSINYVNEQKSEQHLRFLSTLLNSFSSSQVFKVLLGDEKQNIVKSKPLEIARLAQKNPAVQFLYQKIIGWLNEDQRKDAGFLVDILYSALRCCDSDLERKAVLDDLIEACSSADKHALVTSWLKGDILGEKLVTLADHLCNKDLEPTVSSEPCFSERWTLLSLVLSQHVKNDYLIGEVYVERIIVKLHETLSKAKKLSEAENNDSSVSFICDVAYNYFSSAKGCLLMSSSEDLLLTLFQLCAESKEKTHLPDFLICKLKNTWLSGVNLLVHQTGDTYKQSTFLRLSAQWLKNQVQSSSLDITSLQVLLSAVDDLLNALLESEDTYLLRVYIGSVMPDNSEWEKMRQSLPMQWLHRPLLEGRLSLNYECFKTDFEEQNTKKLPSHLCTSALLSKMILVALKKEIVLENNELEKIIAELLYSLQWYEELDNPPIFLTGFCEMLQKMNITYDNLCGLGNTSGLLQLLFNRSRENGTLWSLIIAKLILSRSVSSDEVKRHYRRKEGFFPLTEGNMHTIQSLCPFLPKEDKKEFIAQCIPALLAWTKEDVCSINGGFGHLAIFNSCLQTKSIDDGELLHGILKILITWKKDHEDIFLFSCNLSEVSPEILGVNIEIIRFLSLFLKYCSSPLAESEWDFIMCSMLAWLETTNENQALYSVPLVQLFACVSCDLACELSAFFDSTTPDTTGSLPVNLISEWKEFFSQGIHSLLLPLLVTFTDESKDTSETSFQNAMLKPMCETLTYIPKDQLLSQKLPARLIAGQKTNLPEYLQNLLNTLAPLLLYRARPVQIAVYHMLYKLMPEFPQYDQDNLKSYGDEEEEPALSPPAALMSLLSTQEDLLENVLGCIPVGQIVTIKPLSEDFCYVLGYLLTWKLILTFFKAASSQLRALYSMYLRKTKSLNKLLYHLFRLMPENPTFSETAIELSNKDPKTFFTEELQLSIRDTSTLPYHIPHLACSVYHMTLKDLPAMVRLWWNSSEKRVFNIVDRFTSKYVSNVLSFQEISSVQTSTQLFNGMTVKARATTREVMATYTIEDIVIELIIQLPSNYPLGSITVESGKRVGVAVQQWRNWMLQLSTYLTHQNGSIMEGLALWKNNVDKRFEGVEDCMICFSVIHGFNYSLPKKACRTCKKKFHSACLYKWFTSSNKSTCPLCRETFF
The following text describes a protein:
Function:
Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
Sequence:
MRMHLPTLLKNKEKSQRSRQMSSSKTIGIIGGGQLGQMMAISAIYMGHKVIALDPAADCPASRVAEIIVAPYNDVDALRQLADRCDVLTYEFENVDADGLDAVIKDGQLPQGTDLLRISQNRIFEKDFLSNKSQVTVAPYKVVTSSLDLADIDLSKNYVLKTATGGYDGHGQKVIRSEADLEAAYALADSADCVLEEFVNFDLEISVIVSGNGKEVTFFPVQENIHRNNILSKTIVPARISESLVDKAKAMAVRIAEQLNLSGTLCVEMFATDDDVIVNEIAPRPHNSGHYSIEACDFSQFDTHILGVLGAPLPVIKLHAPAVMLNVLGQHVEAAEQYVTENSSAHLHMYGKIEAKHNRKMGHVTLFSDVPDSVDELGEGIDF
The following text describes a protein:
Function:
Catalyzes the NAD(+)-dependent oxidative decarboxylation of homoisocitrate to 2-oxoadipate (alpha-ketoadipate), a reaction involved in lysine biosynthesis through the alpha-aminoadipate pathway. In addition, has high activity with isocitrate, but is inactive with 3-isopropylmalate.
Sequence:
MQICVIPGDGIGPEVIAVATAALRVLAPDLTIKEAEAGWAVFQRTGTALPETTLALAREATAILFGAVASPSHPVPGYRSPIVELRRTLDLYANIRPTVGNEVDLVVVRENTEDLYIGRERLEDDGATAIAERVITRAASARIVRTACELARTRQAYGHPGKVTIVHKANVLRVSDGLFRTVALEVAADYPELTFEERLVDVAAMQLAAQPQRFDVIVTTNMFGDILSDIACIHGGGLGVAASSNLGHGRALFEPVHGAAPDIAGRGIANPTAALNCVVMLLDWIGRPHAAERLRSAITAVAAAGIRTPDVGGQATTREVADEILNQLSAQM
The following text describes a protein:
Function:
Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectodermal cell P12 specification, movement, body length, male tail development and dauer induction. Functionally redundant to wrm-1 and hmp-2 (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Membrane. Cell junction. Note=Mostly cytoplasmic.
Sequence:
MDLDPNLVINHDDTNLSEISYTMEQDSSSYSLEMGGTPSSAGHRKVDMWQNHNFDSGFQTMNHSEAPSIISSLHPSSHLSGMSSMAEYEPIPNLSEQQKQKFDGITKNPTDGQYNTVRAIPELTMLMKDQDNEVVQKAVMIMQNIAKMECDAMRRQNETKIVDPCVIFTLRNLLRDKVDHPNIIRFTLGTLFNICNRQEGIDLVTRAISEQPDIIPNLIRHIGTFANSIYKYAILTMHSILSDKQRGGQSVTIARQQDAIIHVTPWLEAEKSEKLLPVIVDLIRVLCEKNTDQKVKFVKMGGPQKLLHILQQRGYENLLWRSTQLLKTFSNFDAPCLVAFGGRQILAGMLSHGSPRLVLSTLETLRNISDVPSKMKEELLLKSLLELVNSRNAVIRLYSAQTMSNLVANNRPNKEYMCSNNGVVNLCRALAIATKDWQNFQDKEAQQMEDYAESLICTLRHLCVGHPLAEKVQAYVFREPSIFLHKLMTMRPVLLKHTLNLLLKVVSQNALLAPFLLCRIGEIGFVEQLIHILRVACTQLNVQDVIEGVRVKDIVHLCIQILRLITRNPDILNEVDFFLRSPENSRMGDGHTLPIFVLQKANVEENTKSSTLELIYNLMHHEKMADHLERDEILCKMLHSVQMQAANHPELANLAANILKLMSEKRERNRIHYGRHGSFESQFGHLSVAAQRTEVLNSHGETYEGAGEQWSQPMSDDSMMESYCNSSGRDSSKTYNSPMYHSPPSMYPEYPNGPPSGPYYDPHAFTSTRPTPPHYANYDSPPVYNNIPSNQGPSSHLSDQYPYRQGRF
The following text describes a protein:
Function:
Is essential for L-lactate degradation and allows cells to grow with lactate as the sole carbon source. May also allow cells to utilize an alternative carbon source during biofilm formation, since it contributes to the formation of architecturally complex communities when lactate is present.
Sequence:
MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQPAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKKLADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQFTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGRLGRKDKNVKVMHIAEVLNSR
The following text describes a protein:
Function:
Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3. Can repair exocyclic 3,N4-ethenocytosine adducs in single-stranded DNA. Also acts on RNA. Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons. Requires molecular oxygen, alpha-ketoglutarate and iron.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEDKRRRARVQGAWAGPAKSQATAQPAATARSHLHQRPGQTWMNQEHQLLDKQFVFKEPQQVVRRAPEPRVIDKEGVYEISVSPTGISRLCLYPGFIDLKEADWVLEQLCEVVPWKQRTGIREDVTYKQPRLTAWYGELPYTYSRITMEPNPHWPAVLRTLKDQIEENTGHTFNSLLCNLYRDEKDSVDWHSDDEPSLGRCPVIASLSFGATRAFEMRRKPPPEENGDYTYVERVKIPLDHGTLLIMEGATQADWQDRSRPSFPPSSARGRRGAGLTLLVLKIICVVVKYT
The following text describes a protein:
Function:
Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ. Involved in angiogenesis inhibition (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Secreted.
Sequence:
MENTGWMGKGHRMTPACPLLLSVILSLRLATAFDPAPSACSALASGVLYGAFSLQDLFPTIASGCSWTLENPDPTKYSLYLRFNRQEQVCAHFAPRLLPLDHYLVNFTCLRPSPEEAVAQAESEVGRPEEEEAEAAAGLELCSGSGPFTFLHFDKNFVQLCLSAEPSEAPRLLAPAALAFRFVEVLLINNNNSSQFTCGVLCRWSEECGRAAGRACGFAQPGCSCPGEAGAGSTTTTSPGPPAAHTLSNALVPGGPAPPAEADLHSGSSNDLFTTEMRYGEEPEEEPKVKTQWPRSADEPGLYMAQTGDPAAEEWSPWSVCSLTCGQGLQVRTRSCVSSPYGTLCSGPLRETRPCNNSATCPVHGVWEEWGSWSLCSRSCGRGSRSRMRTCVPPQHGGKACEGPELQTKLCSMAACPVEGQWLEWGPWGPCSTSCANGTQQRSRKCSVAGPAWATCTGALTDTRECSNLECPATDSKWGPWNAWSLCSKTCDTGWQRRFRMCQATGTQGYPCEGTGEEVKPCSEKRCPAFHEMCRDEYVMLMTWKKAAAGEIIYNKCPPNASGSASRRCLLSAQGVAYWGLPSFARCISHEYRYLYLSLREHLAKGQRMLAGEGMSQVVRSLQELLARRTYYSGDLLFSVDILRNVTDTFKRATYVPSADDVQRFFQVVSFMVDAENKEKWDDAQQVSPGSVHLLRVVEDFIHLVGDALKAFQSSLIVTDNLVISIQREPVSAVSSDITFPMRGRRGMKDWVRHSEDRLFLPKEVLSLSSPGKPATSGAAGSPGRGRGPGTVPPGPGHSHQRLLPADPDESSYFVIGAVLYRTLGLILPPPRPPLAVTSRVMTVTVRPPTQPPAEPLITVELSYIINGTTDPHCASWDYSRADASSGDWDTENCQTLETQAAHTRCQCQHLSTFAVLAQPPKDLTLELAGSPSVPLVIGCAVSCMALLTLLAIYAAFWRFIKSERSIILLNFCLSILASNILILVGQSRVLSKGVCTMTAAFLHFFFLSSFCWVLTEAWQSYLAVIGRMRTRLVRKRFLCLGWGLPALVVAVSVGFTRTKGYGTSSYCWLSLEGGLLYAFVGPAAVIVLVNMLIGIIVFNKLMARDGISDKSKKQRAGSERCPWASLLLPCSACGAVPSPLLSSASARNAMASLWSSCVVLPLLALTWMSAVLAMTDRRSVLFQALFAVFNSAQGFVITAVHCFLRREVQDVVKCQMGVCRADESEDSPDSCKNGQLQILSDFEKDVDLACQTVLFKEVNTCNPSTITGTLSRLSLDEDEEPKSCLVGPEGSLSFSPLPGNILVPMAASPGLGEPPPPQEANPVYMCGEGGLRQLDLTWLRPTEPGSEGDYMVLPRRTLSLQPGGGGGGGEDAPRARPEGTPRRAAKTVAHTEGYPSFLSVDHSGLGLGPAYGSLQNPYGMTFQPPPPTPSARQVPEPGERSRTMPRTVPGSTMKMGSLERKKLRYSDLDFEKVMHTRKRHSELYHELNQKFHTFDRYRSQSTAKREKRWSVSSGGAAERSVCTDKPSPGERPSLSQHRRHQSWSTFKSMTLGSLPPKPRERLTLHRAAAWEPTEPPDGDFQTEV
The following text describes a protein:
Function:
Required for chlorophyll b degradation. Chlorophyll b, chlorophyllide b, pheophorbide b and pheophytin b can be used as substrates. Belongs to the chlorophyll catabolic enzymes (CCEs).
Miscellaneous:
MISCELLANEOUS: Chlorophyll b reductase activity detected in vitro with a recombinant protein produced in a heterologous system. Able to act on the substrate within the protein-chlorophyll LHCII complex.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Sequence:
MATWSGFNVSSSPLLRLRSSSVSNVTKLPFLSPICRRRLLAERFGLATVVVTRQNLTVTPSSAAVEARISGKREPMTPPYNILITGSTKGIGYALAREFLKAGDNVVICSRSAERVETAVQSLKEEFGEHVWGTKCDVTEGKDVRELVAYSQKNLKYIDIWINNAGSNAYSFKPLAEASDEDLIEVVKTNTLGLMLCCREAMNMMLTQSRGGHIFNIDGAGSDGRPTPRFAAYGATKRSVVHLTKSLQAELQMQDVKNVVVHNLSPGMVTTDLLMSGATTKQAKFFINVLAEPAEVVAEYLVPNIRAIPASGSMKPTYIRFLTGIKAYTKIFSRVALGARKNRYVTEE
The following text describes a protein:
Function:
May function as histone H3 lysine demethylase and be involved in regulation of gene expression.
Subcellular Localization:
Nucleus.
Sequence:
MAGEENNTGAETVPLKVDDVTQIVNIVADTASLKDGEIGDDVAVEEESVPDREKQAIVSETALLKNDLASVEGDDVAAGDSSSIQVIRKYGRRKKKPGRKSNAEIEKEKIGNGTKEETSKGDDDVADGDSISVHASTDATTPAKKRGRKRNTEKENETGKDAEVEGGFSSVGVRKSERPRKIKSLKEDYVSDLEEDVRKKGKRGRKKVIIGVSDENVKTEKKKPGRKRKELFSSGDENEAENEGGTVKKEEKKKPGRKKKVSYSSEENDEDEQDGENGRNVKIEENELISEKNSESGVLSDDNKGYSLRKAKKTKPDCSEQEQTVPKFNKRNPKWIEEESLMCHQCQRNDKGRVVRCTKCKRKRYCIPCLNNWYPHLKEEKIAEACPVCCGNCNCKACLRSSVLINEIKKKTETNNSHEVEPSKYMLKVLFPYLSRLDEEQMAEKEIEAKIQGLSLSELNIKVADIPKKERVYCDICKTSIFDYHRSCTKCSFDICLLCCCELRGGKLLGGADPIEFEFIFRGRDYLHGGEEERVRKKEPRAAALPEIPEWSRSGWHANDDGSIPCPKADGDHGFLELRSTLPPNCISELVCKAKELEATITLQDVKETFDSRCSCLKPVRNEEDIHNNTRKAASREDSSDNLLYCPRAVNLHNEDLQHFQQHWSKGEPVIVSNVLECTSGLSWEPLVMWRAFRQISNTKHKTLLDVKAIDCLDWCEGDINVHQFFTGYTKGRPDWLNWPQVLKLKDWPPSNLFEESLPRHCAEFISSLPYKEYTDPFKGVLNLAVKLPENVLKPDMGPKTYIAYGFDQELGRGDSVTKLHCDMSDAVNVLTHIAEVKLNSVGLAAIKKLTEKHLEQDKRELHGDNQDGETTVNKLDNSSSINASDEKNCVPVMENRGDSLDGALWDIFRREDVPKLEEYLKKHFREFRHVHSSPLKQVIHPIHDQHFYLTIEHKKRLKEEYGIEPWTFFQKLGDAVFIPAGCPHQVRNLKSCTKVALDFVSPENVGECFRLTEEFRKLPVNHRSTEDKLEVKKMIIYAMLELVEKLEKARSGKTKVPM
The following text describes a protein:
Function:
Adenine nucleotide transporter involved in the uniport of ATP and adenine nucleotide hetero-exchange transport between the cytosol and the peroxisomal lumen. This transport is accompanied by a proton transport from the peroxisomal lumen to the cytosol. Transport of ATP into the peroxisome is required for beta-oxidation of medium-chain fatty acids (By similarity).
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Sequence:
MSFENAVIGATASSLANIAVYPLDLAKTLVQTQLKDEFVEAGEEAGEERAGSRRQNRIKPIALRSPQAAEQYKGALDALQRIYGAEGVAGLYRGLGSSTVAGFIQSFSYFFWYTLVRKHYFRLKQARGGDARFSTPEELVLGIVAAATSQLFVNPINVVATRQQTRGQAAGAADMRTVAREVHAENGWRGFWAGLKVSLVLTVNPSITYATYERLREALFPTPAAASHLVDSAALLSPGQNFVMGVLSKIVSTVLTQPLIIAKASLQRSGSCFQDFHQVLHHLYSTEGPLSLWKGLGPQITKGVLVQGLLFMFKGELTKMLRKLMFYLALLRSSRRALKG
The following text describes a protein:
Function:
Nicotinic acid-CoA ligase; part of the gene cluster that mediates the biosynthesis of pyripyropene A, a specific human acyl-coenzyme A:cholesterol acyltransferase 2 inhibitor. The first step of the pathway is the synthesis of nicotinyl-CoA from nicotinic acid by the nicotinic acid-CoA ligase pyr1. Nicotinyl-CoA is then a substrate of polyketide synthase pyr2 to produce 4-hydroxy-6-(3-pyridinyl)-2H-pyran-2-one (HPPO) which is further prenylated by the polyprenyl transferase pyr6 to yield farnesyl-HPPO. The next steps consist of an epoxidation of farnesyl-HPPO to epoxyfarnesyl-HPPO by FAD-dependent monooxygenase pyr5 and a cyclization of the terpenoid portion by the terpene cyclase pyr4 to yield deacetyl-pyripyropene E. The 2 cytochrome P450 monooxygenases pyr3 and pyr9, and the 2 acetyltransferases pyr7 and pyr8 are involved in the conversion of deacetyl-pyripyropene E into pyripyropene A through several cycles of oxidation and acetylation steps. Pyr7 acetylates deacetyl-pyripyropene E to pyripyropene E which is oxidized to 11-deacetyl-pyripyropene O by pyr3, which is in turn acetylated into pyripyropene O by pyr8. Pyripyropene O is then oxidized to deacetyl-pyripyropene A by pyr9. Deacetyl-pyripyropene A is finally acetylated to pyripyropene A by pyr8.
Sequence:
MEPHGETDLVSFAFSSPTPFDPTRPIYLDAQNPSRAFNARQFRLLVRSLIAGLRALGLKPGHCVLVQLENTVIHSALFFAIVGAGGVYMGCDVGSPAHELTHLLRLAEPQLVITAPGALSTLEVCSTQGESFSGQVLLVDELSIDNIVQFAHRAAAAGAEAQTEGLVDQTAGPCIRLESLLQHGESDWLRFEDREQSKRTPAAMFLTSGTSGLPKAAISTHHTIISHHLSVHYRVPYPVVRLMALPMYHSFGDFWTNIFPIRYGEPLYVLPRFDISTFLDAVRQHHISETYMVPAMVQILSQSSLPVAESLASLRYVGISGAPIDGFSIQRFQRLLSPDAVAGNLWGMTEVGVVFQNRYRVPLQFGSVGTLLHGYELRFVDPATGEDVAGTPDSPGELYVRGPGLLLGYKWRTDDKDEQGWFRTGDMVYARDGNYYIIGRTKDLIKVRGQVPDSLNSWTSHSTNRLCDSRYSVAPAEIEGILLKDPGVKDAAVIGVMLPDGSSEVPRAYVVRAGISPESTADQLTDLVQTQLASYKALDGGVVFVDEIPRTGIGKPHRARLSQLDREREKLASILGVSVPA