lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin. Dephosphorylates phosphotyrosine and synthetic substrates, such as para-nitrophenylphosphate (pNPP), and has low activity with phosphoserine and phosphothreonine substrates (in vitro). Has also been shown to dephosphorylate MAPT. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates. Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane. Note=Colocalizes with glycogen synthase in punctate structures in the cytoplasm. Primarily associated with polyribosomes at the rough endoplasmic reticulum, and also detected at the plasma membrane. Under glycogenolytic conditions localizes to the nucleus.
Domain:
The CBM20 domain mediates binding to cytoplasmic glycogen and to Lafora polyglucosan bodies.
Sequence:
MLFRFGVVVPPAVAGTRLELLLAGSRPELGRWEPRGAVRLRPAGTAAGAAALALQEPGLWLAEVELAPEEEAADGAEPGRIDTFWYKFLQREPGGELHWEGNGPHHDRCCTYNENNLVDGVYCLPVGHWIEATGHTNEMKHTTDFYFNIAGHQAMHYSRILPNIWLGSCPRQLEHVTIKLKHELGITAVMNFQTEWDIIQNSSGCNRYPEPMTPDTMMKLYKEEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLENGHTVYVHCNAGVGRSTAAVCGWLHYVIGWSLRKVQYFIMAKRPAVYIDEEALAQAQQDFFQKFGKVHSSICTL
The following text describes a protein:
Function:
Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3'. Mediates the transcriptional response to hypertonicity. Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17. Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA.
Subcellular Localization:
Chromosome. Cytoplasm. Nucleus.
Sequence:
MLQPLIKQVPNMSMESQSFGGSNFFSLQGNILSETLFSSTQSDFMKGANLMQDVMLNEDSECGDLIVAGEVSGVDDLDHGYDTNSDLSSPMSAKSDWGDASTPSSTGSNHDEGLLADDTSSLFSSCLDEDTCYSSWDQSYESQGKSPAMSPAINQPILDLSPRSPMVGLHSSAAPNDFTVALHKLLQPSQQGVETPSEASKPIRKRSATSLSSCGLTPRKRARKYPSLIQTLPDKLNGGEIHITVQPEKHHRARYRTEGSRGSVKDDSGENFPKLKLLGINQQVLLQVFVVTDQGKVRPHGYYQACKVTGRNTTPSEEKDVEGTTVLEVPWEPVDGKMEISVDCIGILKLRNADVEQRIGPLRSKRKSTCVRLAFRVIVPASDGSFNVVQTVSRSITCTQPLGHPEILKKSLSQCSVAGGEELFIIGKNFTSKANTEVKLRQLDGSGKMTWEGNCEIDKALFQNNHIVCKIPPYPNQNLRTPATVYLVVTGKPNQCSDSDAHPIVYQPKIDHVVMHTPTVANGDKMQVGLAVAPSTYVLPPTPTSPVETFMQVPSTVSSGPVKVEPQPVILQAPPTPSPQANEEEFALTLQMLATAYLQNKDMYNNLLQTTHVEDTVFDRQWAEIEDMIQSAEMINEQPQVFERQSAEMIIEQPEARCDVALSNMVQVQADVPAVVNPGNGESQFLMNTEVDLSKVAELAVIYSNSDLPCFTDPHMIDDVLDVMSNN
The following text describes a protein:
Function:
Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4'. Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation.
Subcellular Localization:
Nucleus.
Domain:
The C-terminal region is necessary for NEUROD1 promoter DNA-binding and transcriptional repressor activity.
Sequence:
MPRGFLVKRSKKSTPVSYRVRGGEDGDRALLLSPSCGGARAEPPAPSPVPGPLPPPPPAERAHAALAAALACAPGPQPPPQGPRAAHFGNPEAAHPAPLYSPTRPVSREHEKHKYFERSFNLGSPVSAESFPTPAALLGGGGGGGASGAGGGGTCGGDPLLFAPAELKMGTAFSAGAEAARGPGPGPPLPPAAALRPPGKRPPPPTAAEPPAKAVKAPGAKKPKAIRKLHFEDEVTTSPVLGLKIKEGPVEAPRGRAGGAARPLGEFICQLCKEEYADPFALAQHKCSRIVRVEYRCPECAKVFSCPANLASHRRWHKPRPAPAAARAPEPEAAARAEAREAPGGGSDRDTPSPGGVSESGSEDGLYECHHCAKKFRRQAYLRKHLLAHHQALQAKGAPLAPPAEDLLALYPGPDEKAPQEAAGDGEGAGVLGLSASAECHLCPVCGESFASKGAQERHLRLLHAAQVFPCKYCPATFYSSPGLTRHINKCHPSENRQVILLQVPVRPAC
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MVHASYQAVVLAGGEDQILYPLTTNTVKALLPVANKPLISYPLRTLAEAGLRSAILVVIGEKAAASVREWISTEYAGSPGALASCEVVSVPEGYGTADALRAVASRITSASFVVLSGDLLTDVPVGALVAQHNLHASAMATMLLAHRRVSPASETKPGKPPKNVDYIGLDPSRQHLLFYASSPDALRDLKVPLPTVRRYGHMSISSNYVDAHLYIFNRSVLQILADNPKLSSLRQDMLPYLTQNQFRIIRAQQLASSAAVMAASSGGGAGAAAGASGGEAGGSGAGAGSGGVGGAGAGASGLLTAPSTEMETDAASDLRFNLHSELPGAHYMDMSHGAAEPPVPESLLRVQVVGPDDGYCARVQDVQMYGEVNREVADPGVALKLSGLKPGRHDNIVPASCALGNKCTVAAACILGEGCVVGDKSSIKRSVLGAGVRLGANVKVINSVLMDGVSVGDGAHVQNSVLCRSASVQAGATLKDCQVGSGCVVAGGVEYKGEVLVTKGAAAGRCGCCAGQIH
The following text describes a protein:
Function:
Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus, nuclear pore complex.
Sequence:
MNKTSSNNISNTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNRILSPFKRNNSKENGNGSVTITLEPLVSPFKLIKSNFKDDVHTNNINNNNNKIKRFLDEDNEFEITIPIRRSGNSINFNIGIVPSSNKKQQQQQQQQQKQKQKKKKTLSPLKKAPGIYSLKDLTIDSDSDSDSYSDNDDNEEYNIKLKSPIKNKIVNNNNNQQQQQKQKEKEEKEEKEKVEKDKKEKDKKKLILNSFQSELIINRVEREREIKINRIVEEKNKEIDDKWVEIKEYNQNQMIKERKEFHSQQIRLNNLIKKQHKKDIKEFSIKLKQAKQKHQSELSESLSLLNQLNKLEQQEIDRHNEELLKYELAIKEEKRKQQQLIERYEQKKREEKQRQLQQEQKEKQEKLEKEEKEKEQQEQQKQLLIKLAKEKEEKEKFEKEQQQQKEKELQKEKELLQQKEKEKEKEKLQQQQQQQQQQQQQQQQQLQQQQQQQNQQNNNLGYIKKDGIIFSLNENSKNFNDFKERSKEFDMIIKFINEKKSMLSREMVEFERQNSKLINIAINQISASQEQVNEKTNKLIKSIQDSQQSDYLKKSTILSIVKKSLSQVESQITFHNASSFPLALVLVRVGEKYPELIDCLLASLNEKCCYTVPYYVSPKENESQSSISKRMGYAFSNDIVGDNDKPIETEDEFHKRICGYLSLYCALILKSEQPHKSSSSSSSSSSSTMMFGFGTQIGNNNNNKLINKNLNIESSLRWLKDLVSLRPRRITSYLFVTFFTHLGNLLSKNQKSSLEFKIIVGKIVEENFFNQMNKPGTEGSFSRLKNLIEEYYKTGTFQQHEGVDF
The following text describes a protein:
Function:
Chaperone that confers thermal protection to other proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MFGRDPFDSLFERMFKEFFATPMTGTTMIQSSTGIQISGKGFMPISIIEGDQHIKVIAWLPGVNKEDIILNAVGDTLEIRAKRSPLMITESERIIYSEIPEEEEIYRTIKLPATVKEENASAKFENGVLSVILPKAESSIKKGINIE
The following text describes a protein:
Function:
Component of a biotin-dependent acyl-CoA carboxylase complex. This subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, resulting in the formation of carboxyl biotin. When associated with the beta5 subunit AccD5, is involved in the carboxylation of acetyl-CoA and propionyl-CoA, with a preference for propionyl-CoA. When associated with the beta6 subunit AccD6, is involved in the carboxylation of acetyl-CoA and propionyl-CoA, with a preference for acetyl-CoA. When associated with the beta4 subunit AccD4, the beta5 subunit AccD5 and the epsilon subunit AccE5, forms the LCC complex, which is involved in the carboxylation of long chain acyl-CoA. The LCC complex can use C16-C24 substrates, the highest specific activity is obtained with carboxy-C20-CoA.
Sequence:
MASHAGSRIARISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVLQQFRIANGEKLDITEDPTPRGHAIEFRINGEDAGRNFLPAPGPVTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGVEGLATVIPFHRAVVSDPAFIGDANGFSVHTRWIETEWNNTIEPFTDGEPLDEDARPRQKVVVEIDGRRVEVSLPADLALSNGGGCDPVGVIRRKPKPRKRGAHTGAAASGDAVTAPMQGTVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEIK
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in the signal transduction pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MDHRKSVDFTNEYIKQQTENQNHTPRGHRMMANFTIRKWNSETNFNEDDYGAIPTKSSIANLLNKFLKSRPTKDDLEMNKILKSEYKPITLRYSLIEILCNHIEKYALEQEGIFRVSGSNQQIRLFWQTFTTDNIEFPINEHNVAGALKLYIREQSEPLVPYEMFSNFISQLGDGGPVTFTAITNLMSKITPENLKIIKRLIRTAVIIVRHSQLNKMDANNMGIVFGPNIFKSRPDSPNIFSEAKYSNESVSFLISNYLNVFPDLEIPILGTETNTEENELLNNNNNNNNVIMPTTTTTTTSASSSILPTDSSNNNGGGSASSPVTKSIPLSSIGSSSTSPIISPSSSSSSSPIVGTNLTTGSIHSTSPTPFSLLATTTSTTTTNSNKVNSIINSTSQSKSQLLPIHPSLLDTNQMIERVEGNPLSQMKRKDFSITHHLSTKLQKTKHFRKEEIWDCFLILKVSGNLVNVKNSTTTTTTSTSTSTSTSTSTSTSSTTTNQPNSITQSNSASNNSLINNGKIKKSTTNLISQSNSQSSLQLNQTNSNNNNIVTLTPVYILITSQNVFFFDTRIYNIQYILPHSRLKEISVDVVNKGLFSILDGESHKLSFFLVPRPRVIDLLVRSLERGRAIAKLTNKSLASLQSRKFPLLESNSGAGGTSNFGKLPESRPVFESLAQNGFTELDVWEGTVDLLEVVKKFHHILIPSADQSKCVVEFLLPAIPEFKGIYRKSYKLDSKTTVYKIICLICEKAKLEPSKFLLRTLKGRTLFDNKSLGDFGLGTLFTSWQLRLIALESPESTGNFVVEFLMPDIPEFKGMQKKAIKVDAYQPLKRIMKGLCDKLKIPNHHYYHLIGPEGEVLGDNDVLSSIGLGIKYKTCKMKLAKKVFPVGKNPELDTPMVRSLVIDNIIGLAWSKIKDRHNERIRLYCKQMLDYIVDQTFVEIAKAELVPKRVAMLGKNSRYEFYHALSLKEEEDMILMDIQGYKETVYQSRSIVPSEPDSSPNYPLYRQKLPTIRGVGPINSIRDIKVNSAKNNFLSELKDNNKQQQQQQIGNTNDEHTIKPSQRIKYIAPTPVLNNPNSIVQLLALKPGASKLVEQLKNRMTITTSKINIFDVEDLVPKNSPVLSRKSYKL
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds directly to 7SL RNA. Mediates binding of SRP54 to the SRP complex.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MKTKIVEVITFYSFKRPPVHDYCESSFCRSRSILDLLAGELTKITTSINIQRCNLPTTIGMMDGGTPNFKTWNILYPVYINSKKTIAEGRRISAAKACENPTSLEIGDCCGHLKIPFAIEIDKAYPRDFMQVGRVRFLLKRPDGSLHNPLVASKKQLMIRVAELVPRHPGRLKKQEPASTSNAVPSKSGKGGKKKR
The following text describes a protein:
Function:
Demethylates proteins that have been reversibly carboxymethylated.
Sequence:
MPLGPIVVAPHEEHNITLPSGDVFRLILFGGCDGDLVRRGEKPPPTLFCLHGAGMSSSNFHVLATHMTQHAKSSAHEESPYAVRVVTFDMRCHGDSTRRGGEGSLTLQVLVDDFRALLRTVKESLFSATPHFYFVGHSLGGSVLVHGLRGEADLLQLAAGVVLLDVVEGTARISLQHMDKFLENRPRQFHEVAEATQWFLRHGGMNSAASAAVTVPHLLRKEGDHFVWKSNLEAMAPVWPQWFDGLDECFVTLPCPKILCLASTERLDTALTIAQMQGKFQLEVLGNSCGHYVMDDQPSAVAAVLQRFIRRIETLTEKLKCSIRKPVK
The following text describes a protein:
Function:
Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MKKLELTLNENGGTGQGIIRFDGGETELLVRIPVGTNFHNADVSIITNMPEESNFKPIKEFRIMEDYVFSSILKYPGKWYLQLKLNSNEGPKVHYIIDPIITINGKKLTPSALNIQTNYARCIGKLEDWVKNLKVIADEGYNIVHLPPFANCQNSSLYSISDFLSISDEITSAPPEKRWQVLGDTLKDVEKKLNLGFMVDVVLNHLRVQSTIIDAHPEWAYTEETAPWLSTAMLVDDIVYKASQLIDQTRLNDFEGTKNYLSDVLFKSELSKLYLIDVDHYISTLSKYRTIDLSKTDLILRLRAKNYTEQQKVNYILSKGINGNKIDYNIAAALYWGTGEKLSKTSLEELEKALKFINESLIEKFKKLCDTIATNDANWLKNNKQARRLFSIHNINGKTLHYACNGYILRPHTKINLAGPNSDVYLTRELNSWQSTVKLRYGTQRSDNPELWDYTTEYATRVAKIAHAIRIDNAHATPVEVVEHIIKSIRKVNPNIYIMPELFSTGEDEDIEIIQRLGINGFMREGCHNQSAEQMGSLITRSGGGRVGDVSQLTVNNIHPTDKIPAVIFDLTHDNNINDVKDRLLLMAPIAMSASPIASTRGFDNLLDFNPSCVTEHRLYPTETPALSKVRKELNELHTSLASSANDLFYRTFGDILTILRADKTGKGVWMIVRFNTQLETPDHIPLPTTEMKKRFEYRLENIVLSKEMKNGNCKLIENENTVFIENNLLRVDRMVGGTVALFDVGISNVTSQIIERVSSKTFSTEVSTRLQYLSLTDLNYLLYRSESEEYDTVGAGAYHFDDYGTTFYCGIDGVVRAIERCSTTIKGMDHPLFKNIVQGDWLMEYTTKRLRVDNLSKFSLFLQTIFNKLKNIPRYLLPLYLYMTLKTINGVAKEVIYSKMATWIVDGDDFIKNLACATVAFHGVSKSAPLVDKEINDKYNIIQNGWNASLAAGLPHFSTDFMRNWGRDTFIAFRGLFLVTGRYEDAKNYLVAYASVLRHGLIPNLLDSCRNPRYNARDACWFFLQSVQDYYDMAPDGPEVLNLSVKMIFPSDLHRVDRVRKEKMIDVIIEILQRHANGIHFREWNAGSQIDSDMSENGFNVDVVTDFSTGFVIGGNAQNCGTWMDKNGSSELAGNKGIPGSPRDGADVEIIGLLASVLKWLAKLYTEKVIKVEGVNVSGKTITWKYWHSLIIANFEQYFYIPSNPKHDSVYAIDSDLVIVRGIYKDTVGSSNPGHDYRFRPNFLIAMTVAPEIFDQVHAVRAIEMAEKHLCGKIGMRTLYKGDSYYRPRYENSNDTNDFFTSKGYCYHNGPEWVWLTGYFFRASLRFRRGFTDRMKRMLAEMKGWLNRSITGGLPELTQADGEVCTEGCPMQAWSVGCTLEMLFDYSFFKEEDTFNWGEYIDDSSDVEESQN
The following text describes a protein:
Function:
E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
Sequence:
MPEVKVPELAESITEGTIAEWLKNVGDSVEKGEAILELETDKVNVEVVSEEAGVLSEQLASEGDTVEVGQAIAIIGEGSGNASKENSNDNTPQQNEETNNKKEETTNNSVDKAEVNQANDDNQQRINATPSARRYARENGVNLAEVSPKTNDVVRKEDIDKKQQAPASTQTTQQASAKEEKKYNQYPTKPVIREKMSRRKKTAAKKLLEVSNNTAMLTTFNEVDMTNVMELRKRKKEQFMKDHDGTKLGFMSFFTKASVAALKKYPEVNAEIDGDDMITKQYYDIGVAVSTDDGLLVPFVRDCDKKNFAEIEAEIANLAVKAREKKLGLDDMVNGSFTITNGGIFGSMMSTPIINGNQAAILGMHSIITRPIAIDQDTIENRPMMYIALSYDHRIIDGKEAVGFLKTIKELIENPEDLLLES
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, flagellum basal body.
Sequence:
MPKKGGKKSSKLSRMSEEERLLYMQQKLLADEEQSKKKEDMLMQFLKDKLAKEEQSSKINLTKLNVQWRSVLREVKTKELRKDIEILSQTFERVVDCKESVIKALAQDVEEAEEQYAHALRGHLQNIDQLLDLQRERLALLQEEYQQELDAIQKEFETERKMIIQQKETEATYLQNVLLAMEQNTTESENEAKLEYQSMRDEIKNKSLEEKHALRVLLEGSVEDLWKQFQAALKNYTDSTEDRRITFETLKAKDEKSAQEIQMQMKKLQKIQDSITSIKNRITTHARESEEQNRRLREDKEVVHKQFQKLKSQMNQARSAEHSRLATLTMQSNATLKELQRIIDKGESILRLAEMCRKLETEEEKVLPFYPSSLSNEDREEAERASMEKPTVELAVLMQEYSALDQFWKRYNKVLLERWALDREKAVLTHDNQKLRYLLKQYLDGISVSDEVLSQQNPLLILNNRSNLQQKPLPVPVTDARVRRPVHNVIEAAHIVSQTL
The following text describes a protein:
Function:
Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20)).
Subcellular Localization:
Nucleus.
Sequence:
MDIHKKRPKPTDGSNPFEGMKIASHDALVALKQRSKCSECRRSRKYFCYNCYVPVPELKDKLPIVKLPVKVDVIKHSREVDGKSTAIHAAVLAPDDVSMYTYPTIPNYDDPSEKVVLVFPSSDAVSLEEFTPRPAKEQDTTKEESKADADDKTKDAECPFQRVVFIDCTWNQTNQIYNDVRLKGLQCVVINDRKTCFWRGQRKSDSYLATIEAIYYFMVDYQQAFLQGKESKDECRYDNLLYFYSFMYGLVHQDDSPDAKMRKEDNG
The following text describes a protein:
Function:
Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux. Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner. May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein.
Sequence:
TSLKASPISVSVDLTRLRAASSARCSTWELLWVNTPQHFPLSVSPSQPRGPQLPSDPGVETPSSHLPQTREFGRHPWTASLSPPHHPRHHPPPTQGAGPGSPAHFPLLPAAWICILRYHQLRDLGVGKRLNRLILCSGILCALGTSVVGNFQQKNQQPTHLTGAFFAFFVGSLYFWLQLLVSWRMRTLPQPGAPWIRPLRLGLCSVCTILMVAMVVLHSWPLRSASAACEWAVAMLLFALFGLLAVDFSGLEGCTLCLQPGPSLSPPPASPMSLQVQLSQAL
The following text describes a protein:
Function:
Has a partially redundant function to WHI3, a dosage-dependent modulator of cell size.
Subcellular Localization:
Cytoplasm.
Sequence:
MSLVHNQTNLNESKFLIERAFSSSSETVPLSKEATYPMPTAYSFSAVRSNSETNIKRENPQGFAKEPIMTSMLHNLTMSTGKGNGNDVNSLAPHDVDVGPYCLLLRNLPKDITLRECYCIFSLATGVSSIELKRDDREPFNDNEKVVVVKFGSLSLVTHYANILNSKSEIFGPSFPFRSHIDVVNEQTQLPVSFQEHVSSGTTNSSPKNYQLSSSAQNEIQNQSFNTISYGKTSSSPLGPSAAKPRPSLLSERSLRFSFNDPFGLETISQRKESVPFLRNSISQHDLSNVTTTPVPAGMPPQKDAGKSLLLLEKDEINESIWNGDELVNDVGNSSFGASLQEPPMSSTPVMEWNASSTANIPLFQLSSQENHQSNLLPPSHHSISQDVPHIQSQPNLNNSGVIHSATSLPHYHLLNQINASTKTQSIQQSVSNVPSNLDLNLQTENGHPQSSAPNGSSIFNNQKVNQGFLVSEQDTSTISRQKECSSTASASAFSKNNETNVAGSTTISQADLSLLAKVPPPANPADQNPPCNTLYVGNLPPDATEQELRQLFSNQQGFRRLSFRNKMNSHGHGNGHGHGPICFVEFEDVSFATRALAELYGSQLPHPRPSLNNKGGIRLSFSKNPLGVRGSNSRSKSGYSFNGSYGKS
The following text describes a protein:
Function:
Essential protein required during embryogenesis. Required for mitochondrial metabolism. Necessary for normal plasmodesmata (PD) development and aperture regulation.
Subcellular Localization:
Mitochondrion.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MAASTSTRFLVLLKDFSAFRKISWTCAATNFHRQSRFLCHVAKEDGSLTLASLDLGNKPRKFGKGKAMKLEGSFVTEMGQGKVRAVKNDKMKVVKEKKPAEIVSPLFSAKSFEELGLPDSLLDSLEREGFSVPTDVQSAAVPAIIKGHDAVIQSYTGSGKTLAYLLPILSEIGPLAEKSRSSHSENDKRTEIQAMIVAPSRELGMQIVREVEKLLGPVHRRMVQQLVGGANRMRQEEALKKNKPAIVVGTPGRIAEISKGGKLHTHGCRFLVLDEVDELLSFNFREDIHRILEHVGKRSGAGPKGEVDERANRQTILVSATVPFSVIRAAKSWSHEPVLVQANKVTPLDTVQPSAPVMSLTPTTSEADGQIQTTIQSLPPALKHYYCISKHQHKVDTLRRCVHALDAQSVIAFMNHSRQLKDVVYKLEARGMNSAEMHGDLGKLGRSTVLKKFKNGEIKVLVTNELSARGLDVAECDLVVNLELPTDAVHYAHRAGRTGRLGRKGTVVTVCEESQVFIVKKMEKQLGLPFLYCEFVDGELVVTEEDKAIIR
The following text describes a protein:
Function:
Involved in intercistronic processing of primary transcripts from chloroplast operons. The endonucleolytic activity of the enzyme depends on the number of phosphates at the 5' end, is inhibited by structured RNA, and preferentially cleaves A/U-rich sequences.
Sequence:
MAGSMSLPSVVAVYPAISWRGGLPVSCRRICLAPLSSLRVRALCRWNDVRIFRGGFLASGSGQCRATNGVVRALEEAKPGSKSRRRRNRPVKAVEEALEGQEPVHLAPSEGSVVCVDVVDGGESSSEQSSPLSSENPVPKRKSASRGRRKKVSEVKSSPTLSEGQDAQIEVSQQIVDKSRVVSTNGAAEESVSASQGANATTGSRRRRRSSAKRDGAAVSASSANSKPAQAGQASEAGVDVNGKALEISDREVESPVISVGGSRRKKNVNSNSQEAAPNGSVATSMNEGGSNSISSAESSAKDASLNSSTNVDNELIHGDRIRNSEVRSVTNGSIPAAQPSIEKKETKKRPRSRRKRGQEAQDVKLLGDEELHTIGQVTALSSINGEVERLEGDEKSGKISEEVVNEGHAGGLTPVDSKTKSDAQTDKENGEPKKLKRAKKPRKKPGAVADLDDNTVDKAQVAQSVLLVETTDSETVSSSGSEDDETAGVHVHPIINQDESVLHTPPELKEPFAGADVVCAADVSPPKRRSRRKRQSESNKKVTAQAAIESESEGSDTPSESGEVKDIEGSSRVQFPAPTWGPQWWDEIQAKSQASISFQDIAERKEVSQEPVFEDTKMIEIKESAEKSTDLNNWNGDSDALHRETRSVAETEKPGRYVKQPQFQMSPSETPDQWSKERMLMLVKPTEEPWLLESIIATEMDEESLREAQSTQNQEVSEAPAIIEEPRKLSPVGDNYLRPDTADVKKEPEVEVEILINTSECTMQRMAILENKKVVEFSIEPVNTKVQVGNIYLGRVKQLLPGMSGVFVDIGGPRLALLDIARNQYPYTFPPVCGSGNHLSTDSVSGGSLQDVDLNLSDEDANFTEEEEEEEEEEEEDEEDNKDEDEDEEPYEEGIARSIVVDRVSGEAENFKDSPEEKVQVKKLSKAWEPHRQGSPITVNFGRKFSKWRNVEEGMPIIVQVKKESMGKKGPRLTAFPSLAGRFWVLIPRGNSVGVSARITGPERRRLKLLAQKLQPEDLGITVRTEAIGHEQEELERDLTRLMDAWKEIMEKAAAAAVAVERGEEAAVPVLLHREMGQTLTIIRDLFTEKVSRVVVDSAQSFQEVINYLQEVAPHLMNRVVLYSGKVPIFDKFNVESDLDKFFSERVKLPNGGYLVMQETEALVSIDVNGGTGMLGHSMKQREAILNVNLAAAKQIAHEIRLRDIGGIIVVDFIDMDNHEDEKLVYEEMRRAIQRDRSKVSISEISEYGLMEMTRKRVRPSVTYTIHSSCACCKGTGRVEALETTLSKIERAIRRVLADHPDVSSDASTWPQILLRVEPSMLEFLKSWKKKRIIQLGHSLRVWINLKLGMELSHGQFEVTEVPRTSSKKSSAGVPSASPSTISQQEAAVTASVLGKRMWSKRKRFFS
The following text describes a protein:
Function:
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSLQAIVYEDNKLSVLDQLLLPHEHKYIPIKSVEDAYSVIKNMQVRGAPAIAIVAALAVAVSLVNVKTDDLRNYVIESFERLKQSRPTAVNLFQIAYKMRKLAEAYEGEEIRVVVVKEAEDLLARDLRDNHTIGELGSEYVLKLVNKPRLTILTHCNTGSLATSGYGTALGIIRSLNEKGAIERVYCTETRPNNQGSRLTAYELLYDNIASTLITDSTAASIMPKIDAVIVGCDRVARNGDTANKIGTLSLAILAKHFNVPFIVAGPSFSIDMTLPDGEQTKIEERPSRELVMVRGPVVRDFTTHQFGARESVHIAPINVKAYCPVFDVTPADLISAVVTEKAVFTKGPNGYEFKW
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Sequence:
MISDVQLAIFSNVLGVFLFLLVVAYHYINANTGKPSAKAK
The following text describes a protein:
Function:
Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells.
Subcellular Localization:
Apical cell membrane; Single-pass membrane protein. Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein.
Sequence:
MEGVWKYFLTILLAVSGSCSHITEGPQNATVLEGSEARFNCTVSRGWQLILWYINNQVSLSITVNGPIISSDRIVPKSYQSGDSFTTEMIIRDVRRSDSGKIKCGLQNSSKEETAFLSVQVVGSLHIQNDSLVLIEDKAHEIICEASGWNPLPNISWVIDVPVNHSSYCSHPKPGDLQSSVSILSLMPQGNGTLTCVASMAGLPFNRSVMVHLTVIKSPLEGDVLSNTFPTWAIILLAVGLPLLLILVIILVVLFCCGCSCKKRKEASYQSKIRNLSISKPNDGPIQAMGNNGKENYGYSSDEPRNTKISSPPSVTSNFSASRQGGQVRLPHQINEEQQQVRTARSTPTVYPSHPRKIRNATLV
The following text describes a protein:
Function:
Proteoglycan required for the timing of seed germination. May function in the abscisic acid (ABA) response.
Miscellaneous:
MISCELLANEOUS: Over-expression of AGP30 severely affects shoot development.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MGIIGKSVSLTLFALLCFTSSVFTLGVNQPGSSDPFHSLPQHLPLPPIKLPTLPPAKAPIKLPAYPPAKAPIKLPTLPPAKAPIKLPTLPPIKPPVLPPVYPPKYNKTLVAVRGVVYCKACKYAGVNNVQGAKPVKDAVVRLVCKNKKNSISETKTDKNGYFMLLAPKTVTNYDIKGCRAFLVKSPDTKCSKVSSLHDGGKGSVLKPVLKPGFSSTIMRWFKYSVYNVGPFAFEPTCPK
The following text describes a protein:
Function:
Involved in formation and maintenance of cell shape.
Sequence:
MRDFLDERPLKLRREVAGDRGYWRVFALALSLVLVSVLLIVLDRQGVIAPARLMVRETIQPLAGWLTQRRSELLSWWATPRDAATMQARIAELEAENTRLAAEVLRLEQARVENIFLRQQLAITQSYPWTILGAEVMIRAPDAARRVLTIARGANDGVRVGMAVIGQQPGGPPALIGVVEAVGPRTADVLMITDISSQLSVRLLQADTAPLGLMQGQWQRGSRMRVELIDRSITMREGDHVVTAGISGALNLPLDLASMPTAVPIGVVEAVRQEGQRQIGEIRPFVDPDQVRYVWVILSQDD