lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
Sequence:
MTVKLSKAEKKVVYDKKLCALLDEYSKVLIAGADNTRNKNSLNLLPLLVGNVGLIFTKGDLKEVSEEVAKYKVGAPARVGLVAPIDVVVPPGNTGLDPSQTSFFQVLNIPTKINKGTVEIITPVELIRKGDKVGSSEAALLAKLGIRPFSYGLVILSVYDNGSVFSPELPVMFINAYKNVLAVAIATEYTFPQAEKVKEYLKDPSKFAVATTVVAVEAAAAPAAVPVEEKKEQPAEESEDGMGFSLFD
The following text describes a protein:
Function:
Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, 2-oxopimelate, oxaloacetate, citrate and malate. The main physiological role is probably to supply 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol where they are used in the biosynthesis of lysine and glutamate, respectively, and in lysine catabolism.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSSSDTKSLPFLYQFFAGAVAGVSEILVMYPLDVVKTRMQLQVQGGAGPHYTGVVDCLKKIVAGEGVGRLYKGISSPILMEAPKRATKFACNDEFQKLYKQAFGVEKLSQPLSMLAGASAGCVEAFVVVPFELVKIRLQDASSSYKGPVDVVRKIVAREGVLAMYNGLESTLWRHALWNGGYFGIIFQARALLPAAHNKTQRITNDLIAGSIGGSIGCMLSTPFDVVKSRIQNTAVIPGVVRKYNWSLPSLLTIYREEGFRALYKGFVPKVLRLGPGGGILLVVFTGVLDFCRAIHYGK
The following text describes a protein:
Function:
Involved in mRNA and protein export from nucleus.
Miscellaneous:
MISCELLANEOUS: Present with 1280 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus membrane; Multi-pass membrane protein.
Sequence:
MESFENLSIRDSFTSGMEHVDEELGGLSDLSISKQGPTLSPQLINRFMPHFPSSPSPLRNTLDFSAAKADEEEDDRMEIDEVDDTSFEEEYNNEPIETHTEATENAVVEEIEATPEERQKQEKNESQDQSVEEVENIVSPHRSTVIKALLSPTDLGVAAATKVEGVVPLPPSANQDDNESSNNNAEGEDIIRNEEVEDEIKSSLGNHKSSQYANAFDSEIIKRELRSRSKYQPIQVSFNTHNYFYSDKDGIKTYSLTKPNHNKIDEFYDQNEAFKLPKPWSPNSHPASRASYALMSYLQLFLNAITTVVIFSFILSFIIALQKDLKSTWEQRKHELQYESRICQEQYLTNRCNQTPGLPALGEQCAIWKQCMDRNNDIFFRARSTLSAKLFGDIINSFIDPLNWKTLFVIFCGVITWCFSSNFLLGFVRAKSYYGNGIKTYPLPSSPKSPTSEETHSSMTASGEDSHLLKQ
The following text describes a protein:
Function:
Part of the nuclear pore complex. Has a critical role in nucleocytoplasmic transport. May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.
Subcellular Localization:
Nucleus, nuclear pore complex.
Sequence:
MADDPDSIPEREMKDFQFRQMKKIRVFESCADLPKERCSLLCVSNRYGLTIAGRERTLKLFWTRDVIAAGRTEGNPNDTVECACAVTADMDVCLHHISLSSDELSLCVCGSGDAAELIMHFYDMRSFLNKQDGQQKRPFCSFRPPASPNTLVQDLKWSPVDASRLAVCLSDGSMMVLDVQDSVTVVAQLPASTGITCVCWSPKGKQVSAGKQDATVVQFTPTLQAKKVIPCPNFYSQDHPVKVLDVLWLSTYTFAVAYAAADGSLETPPELVVVSIPKKDEKRDERYLNFNDLVYGTCTERQHHYYLCHIEDWDLVLAASAAAIEVSIIAKQEDKVNWELWLLEDASRAELPVTENSEDTLPVGVAIDYTSQEDIQLSDEKKVPAAPTLLLLSTDGVLCPFSLLNLNPGVKQLNATAVPLPLDGERAPAAKSSFPAAPVATASSIFPSFPTSSTAAPPPATLSFSAPPPVTSSAPPPYTLPFTAPPSATSSFTAPPPSTSSFSAPPPASFSALPTPTSSFSAPPPTSFTAPPPSTSSFSAPPPASFSALPTATSSFSTPPPASFSAPPPANSSAPPTSSSGFSFSLPPLSSAAPPAFSLGSSSSGFSFNPPKPSSSSAAGFSFSSSTLKEATAAPVPPQRPASMSPIISAPKAPVEPATPAVKMNLTDRFSAVEAPVQPFSLTSTPKPTAESSAPTTAALKPSTHAVLSRVSVPPAAPASSTPSAQPVSVKALEKQLQQKKDSDPVMTGILEEIGLFQKELEDLKSRCRNADFRVGSTDDMRDLRKESENLNTFTLEIKDTTESLHGDISALKTSLLEGFAGAEEARSQSELNQDKDYLQLLYKKPLDPRRDEQLKEIRRLYQYVKFAMEDVNDVLDVEWEKHLEKKKKQRHMIVPQREALFAALANNLDIINQQKQRLDRLTSDLHTLRLYRGSALWSLSSRTPSTPTEQSLDSELESLKDALLKASLETSPKAPAKSPAKMTPVKQSQLRNFLSKRQTPPVRSTAPANLSRSAFLSPQFYEDLDDVSSSSSLSQPVEDPEDSLAVAEEEDEPLPVQLLAPAIPRHPAVVRTPSIQPGFNVQSSPFSRVQSGPINTISTVPKINMDSADSTALATKTVKHGAPPSEKTTPTTIPASQAAARAALSRHMSSQKPGASLTESTLKTVPQVVNVQELKDKGPPVPVSTVISASVPAPAAQVVQQVLATVEANKTSFQGAVKVSAPLAGPAQATAANFVFGGAAKLDAGAASSVCEKNAKSFSFSPASSGFSFTSPSQDNNSTQAKISAPPGKFSFAGSTGAKMAFGSVVSEEPFSFSKVSSPAAAAAAPVISASPEPPKAAKPSTGETLGSFSGLRVGQTEELKESPSGFIFGPPANGSKGFSFNPAQINPTESVTPAESTAEPAKTAPAQAFGSSTFAFKPAEVASPSVKPTFSIPTSSSSSSFPAAAASSFGSLLRAPLPETATNVSAKPEIATSAELAPSADDTQSPAEPCTPKPLTAAESTPPPSTETPIPAESSKPPSPPAAVVSPTPPPSVSPPSESAPLVSEPPLAETVTDTPPETANTSTSAPASTEAPAAPASDKPGSIFAPPPAAAEQVPAVVSTVSPTPVFSSAPSSTSAFGSSAFGSSSASSGFGKPTFGQSAGFGPPAASGSASGFSFGQPAFSASSSSGFGSPAASASTAAPSSVFGPSTASNAGSFSFGATGSGSTASTGTGLFGQSSTSGFGQPSAGFGQGAVFGSNTTTASSSGFSFGQPSGFGSSTSSSSTSVFGQQASGAGVFGQAPSGGLFGSNAGNASSGSGFFSGLGGKPSEDAANKNPFGAPAAAGGFGQPINTGPSNLFGSTGAKGFSFGNSSFGEQKPSGSFSSGGGSVAAQGFGSFSTPTKPAGFGTAPVFGSPPTFGGSPAFGGTPAFGSAPAFSSPQSGSSGKVFGEGTTASNMGGFGFASPSAPSFGSLANQGAGASFGSLAQQQQQQLQQQQLQQQQLQQQQQQQQQQIQQQQQLQQQQLQQQQQQPSAFSAQSGAFSGFSSPSGFGGFGSQNTNQPSSQTFSSWRS
The following text describes a protein:
Function:
May be essential for the survival of the neurosensory epithelium of the inner ear.
Subcellular Localization:
Secreted.
Sequence:
MQACVLWWLALGMLLGIPAGAKPMPEEADPHTQPPAMPYWPFSTSDFWNYVQYFQTQGAYPQIEDMARTFFAHFPLGSTLGFHVPYQED
The following text describes a protein:
Function:
Component of the mitochondrial inner membrane i-AAA protease supercomplex required for mitochondrial inner membrane protein turnover. Together with MGR3, functions in an adapter complex that targets substrates to the i-AAA protease for degradation. Required for growth of cells lacking the mitochondrial genome.
Miscellaneous:
MISCELLANEOUS: Present with 3410 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAVFTPPSGNSNSTDHTHTQDDHDKDDNDIKKFYIRPSLGLKLWGPLVPAPDNLPGLYTLITIQSAVGFFALWRLRRLYKLPPPRRIATGTHSDLSFGELPSEMIVNGKTKIKKDIADFPTLNRFSTTHGDIVLAPPPIIPRQSRFVSVRKLLWGLFGSLLLSQSLLELTRLNFLKYDPWCDEMKSVRDKKFFNNIVKYYHEGIDPTKIKVKDAMNGTPLSTNIPEVKQSVALARAQVEAQNPIIKWFGPLEYKPMSFNEYLNRMEFHLDMFEFFQNKRNIRENSIELINSISHNPQSSSTGLEGLSESKKLHLQNVEKRLHFLASSGDSISAPVKKRSSTTLSRGVILPHDTKGPQDIDLDTIRSLYDPWMTLALETSLSIKFIPTTMPSHTKTPTSTDQPLPGPTPKALTNEKTH
The following text describes a protein:
Function:
Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MSEVTETADSQAIVRAILKVAEDRAGAILEEARRRAREIVESAKKEAEQIVRARRERAEREMREEIARRRSAAEVEANQRILRTKKEIIDNLIRMLQERLQSIADGEDPNWNYREILRNYCLEGIKALGEGEIYLIGREKDRELLEKIAKELKNVKVDPRSLPIIGGVVLRDSRDERRYYNTFDGRLRDYLERKMPYIVERIFGGV
The following text describes a protein:
Function:
Efflux system for nickel and cobalt.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAVSGMLYVVSAFGLGALHALEPGHGKSLMAAYLVGSRGRPWDAVVLGLVVTLTHTLSVYLLAALTLVAARYFAPAWVEHYLELISGLLVLAVGAWLVWQRAIARLWAGWNHRLSHALNMRHDHDHGYHGHSNDHEHDHDHEHGHSHDHPHGSVRTGERLDTRALIALGVSGGVVPCPGALAVLLTAVAAGGLSDVLQGLGLVVVFSLGLASVLIGLGLSLVLSVHWLEKRIDGSERYAPLVGQASAWFIFALGAYLTVRAVWS
The following text describes a protein:
Function:
Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines.
Sequence:
MGPWGEPELLVWRPEAVASEPSVPVGLEVKLGALVLLLLLTLICSLVPVCVLRRSGANHEASASGQKALSLVSCFAGGVFLATCLLDLLPDYLAAIDEALEALHVTLQFPLQEFILAMGFFLVLVMEQITLAYKEQTSPPHPEETRALLGTVNGGPQHWHDGPGIPQAGGTPAAPSALRACVLVFSLALHSVFEGLAVGLQRDRARAMELCLALLLHKGILAVSLSLRLLQSHLRVQVVAGCGILFSCMTPLGIGLGAALAESAGPLHQLAQSVLEGMAAGTFLYITFLEILPQELATSEQRILKVILLLAGFALLTGLLFVQI
The following text describes a protein:
Function:
Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MARYLLFSLAQREIRVARVAVSTTRLQEPPGSLDSLRGFASSTCRPRNYLHKSIVNTLHYQKSLPRLPIPKLEDSVKRYLQAQKPLLSEEQFRQTEGFSRSFKTGIGKELQKMLVSQDKKNKHTSYISGVWMDTYLTLRSPLAFSTNVGLAFHQDPNPSHNNQLIRATNLTVSALRFLKTFRDGYLEPEVLHLYPEKTDTERFKKLIRWVPQALVCTAASIVNVYPMDMSQNFRLFSTTRLPKFYKDKLHTDEKARHLLVLRRGNFYVFDVLDRDGNIVKAAEIQSRLGYILADDCPIPEFPLAYLTSENRDTWAQLRQNLQASGNRSTLKKVETALFCLCLDDFPIQNPDHLSHNMLHGDGMNRWFDKSFNLILTQDGQAAVHFERSWGDATTHLRFLEYIFKDSSNSPAVIPWGQRKTEADYFLAPVKKLDFILDDSLKAGILQARARFNSLTQNLAVRLCQFQQGGKKFLKNQRVSPDAVMQLSLQMAFLGQYNATVPTTESCSTAAFKHGRTETLHVASIHTKRCAEAFIRKPFEHSVGEFQSMIADCSRHHVKLIREATAGHGFDGHLRALHRLATTKGDWLPDFFFDSSYSHLNHNILATSLLASPSLNAGVFPPAVPSGFGIAYSVEQEALQFNISCSSGQNLNEFQQNVKRCLEKIWLILEGKPIIS
The following text describes a protein:
Function:
Catalyzes the phosphorylation of guanosine and inosine to GMP and IMP, respectively.
Sequence:
MKFPGKRKSKHYFPVNARDPLLQSVQAENEVSTSYIVGIDQTLVDIEAKVDEDFITRYGLSQGHSLVIEDDVAERLYQELTHNDLITHEFAGGTIGNTLHNYSVLADDRSVLLGTMCSNIKIGSYAYRYLCNTSSRTDLNYLQAVDGAIGRCFTLITENGERTFAISPGQMNQLRPESIPEEVIAGASALVLTAYLVRCKPGEPMPDATMQAIHYAKKHDVPVVMTLGTKYVIADNPQWWREFLNEHVSILAMNEDEAYELTGLNDPLMASDMALEWVDLVLCTAGPSGLYMAGYTEEAYKRQTQHPLLPGAIAEFNLYEFSRAMRKAHCVDPFRIYSHIAPYMGGPEKIMNTNGAGDGALSAVLHDITANGYHRNNVPNSSKHVRSYLSYSSLAQVCKYANRVSYQVLNQHSPRLTRGLPEREDSLEESYWER
The following text describes a protein:
Function:
May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity). Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity). May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).
Subcellular Localization:
Nucleus. Nucleus envelope. Cytoplasm, cytoskeleton.
Sequence:
MGGSGNWIRSLISNRKPVNDQQEKLSDKSSKKKWKLWRISSESLASSSFKSRGSYAASSLGSELPSFSADEAFTTAMAALIRAPPRDFLMVKREWASTRIQAAFRAFLARQAFRALKAVVRIQAIFRGRQVRKQAAVTLRCMQALVRVQSRVRAHRRAPSDSLELKDPVKQTEKGWCGSPRSIKEVKTKLQMKQEGAIKRERAMVYALTHQSRTCPSPSGRAITHHGLRKSSPGWNWYDDVGTFSRKSSESSVLSEYETVTVRKNNLSSTRVLARPPLLLPPVSSGMSYDSLHDETSTSSTSQSPVAFSSSVLDGGGYYRKPSYMSLTQSTQAKQRQSGLSCNGDARRSAGSDQCTDLYPPGNVWAKSQRS
The following text describes a protein:
Function:
Receptor for annetocin. Activation by annetocin may induce egg-laying behavior through calcium-dependent signaling.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEMDDDEAILLDDIYALASTPNQTIVTSSFPQTVSPGFLARRNEALAMVEVAVQSTILILTVVGNAAVLAMIVSLSRHKDLGRMYTMIGHLSCADLFVAIFNLLPQLLWDVTHRFRGGRVLCKLVKYVQVVAMYASAYVLMSTAVDRYTAICHPMRSHTWTSTTAHYLVIGAWVLALVFAVPQLVIFDYVEVVPGSGVYDCVDHFRPRWTLPVYITWFALAVYVIPLVVLATIYLRICVVVWKSANRKSTPMINVAARTSGATEQPSLDDASVSFNVADGGGVDLDPSGGGGSLSRHAAQLSHRQQQQQANNVVLSRAKTKTVKLTLTVVISYLVCWAPFFVSHIWSAWDPHAPFEGTEMVITLLLGSLNSCINPWIYLAFSDQLRRKVTQCCPRSWGQRPSTLSHDSTDFRSGSRPTHS
The following text describes a protein:
Function:
Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MVLLRSLFILQVLVRMGLTYNFSNCNFTSITKIYCNIIFHDLTGDLKGAKFEQIEDCESKPACLLKIEYYTLNPIPGCPSLPDKTFARRTREALNDHCPGYPETERNDGTQEMAQEVQNICLNQTSQILRLWYSFMQSPE
The following text describes a protein:
Function:
Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane.
Sequence:
MPALVPSRASSCAGEAASTSCCTENSLSSYSSTIASVDSTGFYVTLVVSRWWNQYENLPWPDRLMMQVSSFVEGKDEQGRLLRRTLIRYAILGQVLILRSISTSVYKRFPSLQHLMQAGFMTPGEYKQLQRLGLPHNTFWVPWVWFANLSMKAYLGGRIRDTVLLQSLMNEVCTLRTQCGHLYAYDWINIPLVYTQVVTVAVYSFFLACLIGRQFLNPLKNYPGHEMDLVVPVFTILQFLFYMGWLKVAEQLINPFGEDDDDFETNWIIDRNLQVSLLSVDGMHHDVPPLERDLYWNEAAPQPPYTAASAGSHRQSFMGSTFNMSLKKKDSEEESDTYDKKENDYGSTIGRFLGLQSNDYHPPKTDLKTKLLWSKKDPFLEDQSKNDKQKDQKNDVWKPKDLFRAIPKFKRPSYRQAPQPLGSHLPMVFPPQQSAPSVRYSDTGGGPSAQYQEACHMKKKTVEFNLNIPECPTEHEQPHLDQMHTILKEPGESYPVSDKADTNPVSYK
The following text describes a protein:
Function:
Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MSIPFSNTHYRIPRGFANLLEGLTREVLRHQPKDIPLFGAKYFSQLLQQRQDTDFDPAQWGAALEDRFYNNYDFQHTELKKYTSEPSELKKSKRKSFSMLDNSDTYPLSPSTSLEQKEIETDDMRKMQAATTIQAAFRGYNVRHKVKIHQESFVDNYMKPEPEHEDTDQAKETKCDLMENEDCEFNSKADNNEMHDEKVEIPDSISADELVKSEEFQEAITDSGEKDEEINLVGREGKEREFNSLKPEGSGGQEVDRQEQFTEVSELEIKEPDDSMQNDTIKDATSEEKEERINDVVEHYMITTGKRGETTQDDNLSDLTDQSATYEIQNTEVNTTNESILPDLLYSQTNELESSSNQLLDTSSKEPNPLADSNIDILNEQSSVHIDTSDMENLSGKPDPELLHNIMESLGNQTVLEHEDRSNLESPKENESFRKPQEEALDIPLDDPDANAAAAKIQAGFRGHMTRKKMKGGDKDLKSKDSKDGSSTGGENEGD
The following text describes a protein:
Function:
Probably involved in the defense reaction of plants against pathogens.
Sequence:
MGSRLRLALAASVIACFYVVAHADQGVVVEPATALVRELLDEAALAEGPPPPRKERWSRPADWPARPPKPPRAPRLPPQPVRPPKPPRNPPRPPKPPRGPPREPMSPPPPPPPPPPPPLEEDPPPPPLRPPPPRVPLPPRPSSSVLYRTPAAGGGDQLLAGGNCPDAQAMLDQTNEYRSWHQVGPLQWNEALAASSTAYAQVLAQDCVMRHAAVRDFGENLMQVIRYPASDNTCSVAVRAWYGEVAMYNWRAPAPYRDNWAKGIGHFTQLVWRGTSSMGCGVAVAPYDINVPGARGLTGACKIVVCRYKAPGNVADDNAFLRNVLPSTNTADTTSN
The following text describes a protein:
Function:
Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex.
Sequence:
MSVRDFIKGLPIHDSSNFTHLSNEHGIRTSQKRASVYLPTEDEHSEQLIVMDKRCVLLRYLTQQWDKKTLQRKREHGGDSGNGNGNSSTPNGNSTNSKKRPRLDPNELN
The following text describes a protein:
Function:
Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Mitochondrion membrane; Single-pass type I membrane protein. Note=Localizes to endoplasmic reticulum mitochondria-associated membrane (MAMs) that connect the endoplasmic reticulum and the mitochondria.
Domain:
The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity; The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
Sequence:
MAVLAPLLAFLYAVPGLLRWVSQPYYLLSALLSVSFLLVRKVPPVCSVLPTQREDGNPCDFDWREVEILMFLSAIVMMKNRRSITVEQHIGNIFMFSKVANTILFFRLDLRMGLLYITLCIVFLMTCKPPLYLGPEHIKYFSDKTLEEELQSDGRVSWIIEFFANWSSECQSFAPIYAELSLKYNCAGLKFGKVDIGRYPEVSSRYSISPSPLSKQLPTLILFQGGREIFRRPQVDKKGRAVSWSFTQENVIREFNLNELYQKAKKIRKHQEDTINENEYNDSKKDQ
The following text describes a protein:
Function:
Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).
Subcellular Localization:
Cytoplasm.
Sequence:
MTSTGIRLHAPAPGWAIAADVVVVGSGVAGLTAALRCESAGLRTVVVTKARLDDGSTRWAQGGVAAALGEGDTPEQHLDDTLVAGAGLCDQDAVRILVTEGPDAVRRLIATGAHFDESTEGGLALTREGGHHRRRIAHAGGDATGAEISRALVEAVRARGLRTVENALVLDLLTDAEGRTAGVTLHVMGEGQHDGVGAVHAPAVVLATGGMGQVFSATTNPSVSTGDGVALALRAGAEVSDLEFVQFHPTVLFLGSDAEGQQPLVSEAVRGEGAHLVDADGVRFMQGRHELAELAPRDIVAKAITRRMQEHGADHMYLDARHFGRTMWEHRFPTILAACRAHGIDPVTEPVPVAPAAHYASGGVRTDAHGRTTVPGLYACGEVACTGVHGANRLASNSLLEGLVYAERIAADIAAAHTAGTLHARVPAPLPHPDHSQHPRHPLLPPEARLTIQRIMTEGAGVLRSADSLARAADRLHGLHAEAREALHEHGKTSEPGVDTWEATNLLCVARVLVAAAARREETRGCHWREDHADRDDTTWRRHVVVRLNPDRTLAVHTTDTPEFPPTVHGAQPTHRPQEQ
The following text describes a protein:
Function:
Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.
Miscellaneous:
MISCELLANEOUS: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MSAQKLYASHVPLAPLSRMLLGIGSAVTAISDPKRGDMVAAMGETTAIGPVLENIRKRMESDVVGKRLLLEKPRISNGTIDRKWLRQLPDGTLGKLYSNFLDRLNTSPDARPTVKYIDNLEHLYVMQRYRETHDFTHIALEQKTNMLGEVTVKYFEGIQYGLPMCVTGGIFGGARLLTKNRQELVDRNLPWVVEQATNARFFMAFDWENHFEKQLSEVQKELNITPLSVNM
The following text describes a protein:
Function:
Involved in the galactan polymerization of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacteria cell wall. Thus, successively transfers approximately 28 galactofuranosyl (Galf) residues from UDP-galactofuranose (UDP-Galf) onto the galactofuranosyl-galactofuranosyl-rhamnosyl-GlcNAc-diphospho-decaprenol (Galf-Galf-Rha-GlcNAc-PP-C50) acceptor produced by GlfT1, with alternating 1->5 and 1->6 links, forming a galactan domain with approximately 30 galactofuranosyl residues.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cell membrane.
Sequence:
MSELAASLLSRVILPRPGEPLDVRKLYLEESTTNARRAHAPTRTSLQIGAESEVSFATYFNAFPASYWRRWTTCKSVVLRVQVTGAGRVDVYRTKATGARIFVEGHDFTGTEDQPAAVETEVVLQPFEDGGWVWFDITTDTAVTLHSGGWYATSPAPGTANIAVGIPTFNRPADCVNALRELTADPLVDQVIGAVIVPDQGERKVRDHPDFPAAAARLGSRLSIHDQPNLGGSGGYSRVMYEALKNTDCQQILFMDDDIRLEPDSILRVLAMHRFAKAPMLVGGQMLNLQEPSHLHIMGEVVDRSIFMWTAAPHAEYDHDFAEYPLNDNNSRSKLLHRRIDVDYNGWWTCMIPRQVAEELGQPLPLFIKWDDADYGLRAAEHGYPTVTLPGAAIWHMAWSDKDDAIDWQAYFHLRNRLVVAAMHWDGPKAQVIGLVRSHLKATLKHLACLEYSTVAIQNKAIDDFLAGPEHIFSILESALPQVHRIRKSYPDAVVLPAASELPPPLHKNKAMKPPVNPLVIGYRLARGIMHNLTAANPQHHRRPEFNVPTQDARWFLLCTVDGATVTTADGCGVVYRQRDRAKMFALLWQSLRRQRQLLKRFEEMRRIYRDALPTLSSKQKWETALLPAANQEPEHG
The following text describes a protein:
Function:
Involved in the detoxification of the Fusarium mycotoxin deoxynivalenol by the transfer of glucose from UDP-D-glucose to the hydroxyl group at C-3, forming deoxynivalenol-3-O-beta-D-glucoside.
Sequence:
MESATTSSGDEHRGGAHVLLVPLPAQGHMNPMLQLGRRLAYHGLRPTLAATRYVLSTGQPPGDPFRVAAFSDGFDAGGMASCPDPVEYCRRAEAVGSETLAQVIAAETLAGRAPSVMVYDPHMSWAPRVAKAAGVPTAAFMSQSCAVDLIYGEAWAGRAPLPMADGSALRRRGAVSVDLGPEDLSPFLVSPELYPKYLDVSIRQFEGLEDAGDVLVNSFRDLEPQEAEYMESRWRAKTVGPTLPSFFLDDGRLPSNKAYGVSFFSSDAPCMAWLDRPFLWVVRSNEAQKISEELHGRCKENGLIVPWCPQLEVLAHKATGCFLTHCGWNSTTEALVAGVPMVAMPRSADQPTTAKYVESAWGIGVGMHTDEKGLVRREEVERCIRKVMDGEGKVEYRKNATKWMKMAKEAMQEGGSSDKNIAEFAAKYLSR
The following text describes a protein:
Function:
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm. Rough endoplasmic reticulum. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum.
Sequence:
MGPQGFYWSHPRKFGQGSRSCRVCSNRHGLIRKYGLNMCRQCFRQYAKDIGFIKLD
The following text describes a protein:
Function:
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MREIMPLQARQCQISTKFWEVISDKHGIDPTRTYHGESNLQLERIHIYYNEATGGKYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSVAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLPGFQLMHSLGVGTGSGMGTLLISKIRADRIMNTFSVVSSPKVLDTVVEPYNATLSVHQLVENTDETYCIDNEAFYNICFRTLKLTSPTYGDLNHRVSATMSGVTTCLCFPGQLNIDLSKLAVNLVTFPRLHFFMPGFAPLTICGSQQYHALTVPELTQQMFDAKNMMAACDPWHGCYLTVAAVFRGHISMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAICNIPSRGLKMSATFIGNSTAIQELFKHISEQFTAMFHRKAFLHWYTGEGMDEMEFTEAESNMNDLVSKYQQYQDATAEEEGNFEETEEEVE
The following text describes a protein:
Function:
Converts proline to delta-1-pyrroline-5-carboxylate.
Sequence:
CHKITAPSLGKGHLVNLLPPEHLPWCGGSQGPRMLWTCYPLCSQAGPLARGWQPLSFDGGAFHLKGTGELTRALLVLRLCAWPPLVTHGLALQAWSQRLLGSRLSGAFLRASVYGQFVAGETAEEVRGCVQQLRTLSLRPLLAVPTEEEPDSAAKSGEAWYEGNLGAMLRCVDLSRDLLEPPSLAEASLMQLKVTALTSARLCKELASWIRRPGAPLELSPERLAEAMDSGQNLQVSCLNDEQNQHLQASLSRLHRVAQYARAQHVRLLVDAEYTSLNPALSLLVAALAVRWNSPGEGGPWVWNTYQACLKDTFERLGRDAEAAHRAGLAFGVKLVRGAYLDKERAVAQLHGMKDPTQPDYEATSQSYSRCLELMLTRVARHGPMCHLMVASHNEESVRQATKRMWELGIPLDGTVCFGQLLGMCDHVSLALGQAGYVVYKSIPYGSLEEVIPYLIRRAQENRSVLQGVRREQELLSQELWRRLLPGRRRIPH
The following text describes a protein:
Function:
Inhibits nitric oxide (NO) production in activated macrophages. Acts by inhibiting expression of the host inducible nitric oxide synthase (iNOS). PPE2 is translocated into the host macrophage nucleus, where it interacts with a GATA-binding site overlapping with the TATA box of NOS2 (iNOS) promoter, and strongly inhibits NOS2 gene transcription. Reduction in NO production in turn facilitates intracellular survival of the bacilli inside the macrophage. In addition, disrupts the assembly of NADPH oxidase complex, which inhibits NADPH oxidase-mediated reactive oxygen species (ROS) generation in macrophages and favors M.tuberculosis survival. Acts by interacting with NCF2, the cytosolic subunit of NADPH oxidase, and preventing translocation of NCF2 and NCF1 to the membrane, which causes a reduction of the functional assembly of NADPH oxidase complex and a decrease in NADPH oxidase activity.
Miscellaneous:
MISCELLANEOUS: Shows a strong immunoreactivity toward tuberculosis patient sera compared to that of BCG-vaccinated controls. Could be an attractive candidate for serodiagnosis to discriminate patients with active tuberculosis from BCG-vaccinated individuals. Could diagnose both pulmonary and extrapulmonary tuberculosis cases. However, it has lower sensitivity to detect smear negative and extrapulmonary cases as compared to PPE17/Rv1168c; MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Secreted. Host cytoplasm. Host nucleus. Note=Translocated into the macrophage nucleus via the classical importin alpha/beta pathway.
Domain:
Contains a conserved PPE N-terminal domain and a variable C-terminal domain. The C-terminal region includes a SH3-like region, a leucine zipper DNA-binding motif and a functional nuclear localization signal (NLS).
Sequence:
MTAPIWMASPPEVHSALLSSGPGPGPLLVSAEGWHSLSIAYAETADELAALLAAVQAGTWDGPTAAVYVAAHTPYLAWLVQASANSAAMATRQETAATAYGTALAAMPTLAELGANHALHGVLMATNFFGINTIPIALNESDYARMWIQAATTMASYQAVSTAAVAAAPQTTPAPQIVKANAPTAASDEPNQVQEWLQWLQKIGYTDFYNNVIQPFINWLTNLPFLQAMFSGFDPWLPSLGNPLTFLSPANIAFALGYPMDIGSYVAFLSQTFAFIGADLAAAFASGNPATIAFTLMFTTVEAIGTIITDTIALVKTLLEQTLALLPAALPLLAAPLAPLTLAPASAAGGFAGLSGLAGLVGIPPSAPPVIPPVAAIAPSIPTPTPTPAPAPAPTAVTAPTPPPGPPPPPVTAPPPVTGAGIQSFGYLVGDLNSAAQARKAVGTGVRKKTPEPDSAEAPAAAAAPEEQVQPQRRRRPKIKQLGRGYEYLDLDPETGHDPTGSPQGAGTLGFAGTTHKASPGQVAGLITLPNDAFGGSPRTPMMPGTWDTDSATRVE
The following text describes a protein:
Function:
Receptor for cloacin DF13/aerobactin.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MMISKKYTLWALNPLLLTMMAPAVAQQTDDETFVVSANRSNRTVAEMAQTTWVIENAELEQQIQGGKELKDALAQLIPGLDVSSRSRTNYGMNVRGRPLVVLVDGVRLNSSRTDSRQLDSIDPFNMHHIEVIFGATSLYGGGSTGGLINIVTKKGQPETMMEFEAGTKSGFSSSKDHDERIAGAVSGGNEHISGRLSVAYQKFGGWFDGNGDATLLDNTQTGLQYSDRLDIMGTGTLNIDESRQLQLITQYYKSQGDDDYGLNLGKGFSAIRGTSTPFVSNGLNSDRIPGTDGHLISLQYSDSAFLGQELVGQVYYRDESLRFYPFPTVNANKQVTAFSSSQQDTDQYGMKLTLNSKPMDGWQITWGLDADHERFTSNQMFFDLAQASASGGLNNKKIYTTGRYPSYDITNLAAFLQSGYDINNLFTLNGGVRYQYTENKIDDFIGYAQQRQIGAGKATSADAFWRLSRLRHFLFNAGLLMHITEPQQAWLNFSQGLELPDPGKYYGRGIYGAAVNGHLPLTKSVNVSDSKLEGVKVDSYELGWRFTGNNLRTQIAAYYSISDKSVVANKDLTISVVDDKRRIYGVEGAVDYLIPDTDWSTGVNFNVLKTESKVNGTWQKYDVKTASPSKATAYIGWAPDPWSLRVQSTTSFDVSDAQGYKVDGYTTVDLLGSYQLPVGTLSFSIENLFDRDYTTVWGQRAPLYYSPGYGPASLYDYKGRGRTFGLNYSVLF
The following text describes a protein:
Function:
Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Required for maintenance of sister chromatid adhesion during mitotic checkpoint activation.
Subcellular Localization:
Nucleus. Chromosome, centromere. Note=Localizes to the centromeres throughout the cell cycle.
Sequence:
MSSKKRTKRNRAGDEYKEHKGRSHPRRKFLPPEEPDVSRISKVAGVNQLEELCDSFDQPLHSTAVDACGEEHSENESSGYVPAPQRTNAERSEKMLLETPEGDVHEFSQSGSVREPLMENLNAPNTTRSEVKKKRPSKKSSSDSSVNSPSSVQLWCPNKLKRSSRDITELDVVLAEFEKIAANYRQSIESKACRKAVSAFCSAFEDQVTDLITEVQELKNTKKKNAKVVADIKKKRQRLMQVREKLSRTEPQLIKLQKEYAEVEERRSSLRQVVQFLTDLKELQQDYLDYREENPRKKVVYGASSLPALLVESRRILQAERHFQNINRKLEYALEVQRGKLAKEH