lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.
Sequence:
MKPDPFLFISSLGDCLHTLRILLGPKDETVISLGRKFKLNSGVMRSSYINLAANDLTAICACRRDGSSRGGVGYRHIDSAAVGLNEAEVGRGWKKLGVPREGIFLTSKLWNTHHHPSHVEEALDKTVKDLQTNYLDLYLLYPLGHILHTYQRHIPASRPGHKRFRLVDIPIGDTWAAREKLVNAGKIRSLGVSNLFTIEKMEELLNTADIPPAVNQIEAHPYLLQPKIYISPITYNSMHILLTVPQNILPAAYSPLGNNIFGGPRYTKSSYLLANSKLLENSANMARGPRSEIARRPASVQPDEGTPGPIEAEAPLDRASLALPWKVRLAGHKKGNLMEKFQKNSNWVQS
The following text describes a protein:
Function:
DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.
Sequence:
MSELEQIRLANIERNKALLAALNLPTEAKKESVDPEVAPKKSRKRNSARLESPDDGSDDSAPRTRRKSRRLQGLDPEANALKQEDLGGSGELKRLMQQLNGGVKKERLSGDLSLKEMLTKTGLDEKEWSASLGQLFGDGSRVSQGDFFDEIVKKEEEDTKDIDIKQSRDNLSGLQLGKMSKVTKERIYITAVHPGTDKRIVLAGDKIGVLGIWDVDSDNEPLQLQLHHATIPALCFDQNSNDILYSASYDGSVRSLELKTGKSGDVLDLEAKKNASVGVSDVANPQPHLLYASTLCGHLIRKDLRTKSTEYETLILGEKKIGGFSVDPINTHLLATGSLDRSMRIWDLRATETARTIPGGEVIDTQFQMPHLQAIYNSRLSVSSTDWNLAGQIVCNGYDDTINIFNQSDYFLDMLNDGNGTEPVKKTRRTRNSKLAEPEISDQELPEIKKPSVRIKHNCQTGRWVTILKARWQQQPLDGVQKFAIANMNRYIDIYSGTGHQLAHLGDALMTAVPSALAFHPTQNWIAGGNSSGKMYWWE
The following text describes a protein:
Function:
Involved in the biosynthesis of (S)-coclaurine, the common precursor of all benzylisoquinoline alkaloids such as morphine, sanguinarine, codeine or papaverine. Condenses dopamine and 4-hydroxyphenylacetaldehyde.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MSKLITTEPLKSMAEVISNYAMKQQSVSERNIPKKQSLLRKEITYETEVQTSADSIWNVYSSPDIPRLLRDVLLPGVFEKLDVIAGNGGVGTVLDIAFPLGAVPRRYKEKFVKINHEKRLKEVVMIEGGYLDMGCTFYMDRIHIFEKTPNSCVIESSIIYEVKEEYAGKMAKLITTEPLESMAEVISGYVLKKRLQVFGFEIKPKLRFNLLLCLIICLVIAGGMFVAGVPL
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MAEAAESFADAVVRVEDETGIRAPWRVWPQMRHDSTKLGVPLSLVYTPLKAVANPYRASYAPVRCSGCSAVLSPFTYVDYQKKSYVCSFCSLMQPLPPSYAQITPEYRPAELHDVYKTIEYNLSATQAAAGGHATPQVAPDYAPIFAIVVDTCCEDAEQFAKMKESLQWIVDVLPSNSKICLVSFGSVVTVHELVFDFCPRKVVLRGLVDIPPAQLEQYLGLKTTTQRFLQPLSLCQNSLVQILEDLMKDPWVPPPKCRPHRCLGAALSIATSILQSLSLPAGIPITMDTTNATAVRPTTGFAGRVVLLTSGPCTAGPGTVVDIDLSMHLRHWPDIEKKTDVAKHVKDAQRFYTSLGERAATNGISYHVFSCSVEQVGLYEMYQMVSMTGGHMMISESYSYQAFVRSWRCFFDQLVQAARQEETETTGRGEINEDEEEGDEPELVPLQFGSRAIIEASIGSGGKITGCVGHVVPLPPTVSTKGSQQAPTCSNPAFVAGTFYEGGSKVLSLGGQDNEIGHGFTNRWLASHIDSESTFCFCYEANHDPKNAMALTLPAYIPVQFRTLYIDNVTGDQILRVTTYVFQGANPLSDWAKISSEFDQEAAAVVLAKITMFNLMHRPGITTDEVMRYIDRSIIKLSQAFSSYQLQNAATLVFQPNFEFFPQFLYHFRRSEFIQLFGQSPDETAMKRFQLLRQTTANVLTMMQPVLYAYTVTNPEPTPVFLDSSEATQDRILLFDSFFNVLVWTGSSVAAWRKAEYHLKPEYANVATLLDAPNYEVEDILNERFPSPRYDNADQGTSQARILLARVNPTTTHKSNQTLGGFTLGNGGQPEAVGEVVATDDVSLQKFLAALKESVVQQGK
The following text describes a protein:
Function:
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.
Sequence:
MDTGPWTSHSTIRVSVPLLKDGDCDSSRGIQEVCGMVGRVPVHGALQGSPPALPSNFSRTDDSVINWDSVCGRPQVSGRIVSGEDAQLGEWPWQVSLREHGQHVCGGSLIAKDWVLTAAHCFDQKQLLSAYMVLLGSISSYPQVNEPREFREVAQFIIHPNYLEENNRADIALVQLSSPVNFSSLILPVCLPSTGDPLGHGTWCWVTGWGNIGVNLPLPPPFTLKELQVPLIDAQTCDTYYHENSGIPTEEPIILEDMLCAGFESGQKDACGGDSGGPLVCDVDGIWIQAGVVTWGSDCGLPKKPGVYASVSFYASWIASTIGSSAPELRNFSPSLAGIFLSALLLLLGLLGGTPVSLELA
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Sequence:
MSQDIRKEDGVRSATEYKLSMSSNPGSRRSSMADAESFNDDNMVLKNDVLREYLLPQIKDLTDSVVTLDSNMTRLNFIHDNLVDLNESFGSLLYGLMCNSWCVEFPNAPTRFDKEIRLMNEIEELSAEKSKLKSRLNSLREKPNAQTSDEKMKKPSGISQPIFQKPNVRRPRNALNDENLHKFNRENPPVYDDKREADEDTNSEASFVSNPANSKDMQLFANGSSNNDPKSRLRRKSILHTIRNSIASTSDAYDRKKQQGIQMGRVSLGGGAARVVSGRNMFEQQRTTRHSTTGIPNRVVKKRPPFK
The following text describes a protein:
Function:
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.
Sequence:
MAPSTPLLTVRGSEGLYMVNGPPHFTESTVFPRESGKNCKVYTFSKDGTLFAWGNGEKVNIISVTNKGLLHSFDLPKAVCLEFSPKNTVLATWQPYTTSKDGTAGIPNLQLYDVKTGTCLKSFIQKKMQNWCPSWSEDETLCARSVNNEVHFFENNNFNTIANKLHLQKINDFVLSPGPQPYKVAVYVPGSKGAPSFVRLYQYPNFAGPHAALANKSFFKADKVTMLWNKKATAVLVIASTDVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKATIFNLKCDPVFDFGTGPRNAAYYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSILHKYDVPSNAELWQVSWQPFLDGIFPAKTITYQAVPSEVPNEEPKVATAYRPPALRNKPITNSKLHEEEPPQNMKPQSGNDKPLSKTALKNQRKHEAKKAAKQEARSDKSPDLAPTPAPQSTPRNTVSQSISGDPEIDKKIKNLKKKLKAIEQLKEQAATGKQLEKNQLEKIQKETALLQELEDLELGI
The following text describes a protein:
Function:
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity).
Subcellular Localization:
Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis.
Sequence:
MAPRKRTQNAKSKKNPKAPKLEAFLLDFDDEVHTIVERLKEKTNNLLKDADNLYKTALIKLPMAVRKMNWIEYCNLEKPKSPVDDSKVREEAAQVELAIAGNHTIPKVAAKEAKSSANSEDENMAPLKSTMKKKKASKKAPSTSKKPRTLSISKQGGTIQRTTRKPLITPARSFLDSSIIGATPLITPRFDPRLPKTPALRSALHREKVYSMSVNGSPLSAGGEDIVISVPIGNGECIQLLASEMDSVDLSQLDEKALRSIRNLQNRLTTLCGSSK
The following text describes a protein:
Function:
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.
Sequence:
MASTTALRTGPEYSGIPEVPSGSKTANASPPLDTSLASTMGGSYPVNHSLEQKGEAAHTIPEECERLFCDALSAIFLGERLSRQELLGVDASLTQINNADGEHSRIQMWVEVLDYTTDAIYRGFVTDTNGERTLFVFLMETAVGHGLKSGLIALFELASVPAFGCSQIIACVPRSKDGSELESVRNLGWCGFSLTTLEQFGARNGNCLSNRWLFLSAEA
The following text describes a protein:
Function:
Involved in the biosynthesis of the core oligosaccharide region of lipopolysaccharide (LPS). Required for the addition of 3-deoxy-D-manno-oct-2-ulosonic acid III (KdoIII) to the KdoII residue of the inner lipopolysaccharide core. May also play a role in a lipooligosaccharide (LOS) biosynthesis pathway.
Miscellaneous:
MISCELLANEOUS: KdoIII is found in only 10 to 15% of the LPS molecules on the cell surface of E.coli K12 (Probable). Overexpression in an E.coli F470 isolate (with an R1 core, lacking the waaZ gene) leads to the formation of truncated LPS structures, lacking up to 3 hexoses from the outer core, and which contain a KdoIII residue not normally found in the R1 core.
Subcellular Localization:
Cytoplasm. Note=When overexpressed, a significant amount is also located in the membrane fraction.
Sequence:
MKNIRYIDKKDVENLIENKISDDVIIFLSGPTSQKTPLSVLRTKDIIAVNGSAQYLLSNNIVPFIYVLTDVRFLHQRRDDFYKFSQRSRYTIVNVDVYEHASKEDKLYILQNCLVLRSFYRREKGGFIKKIKFNILRQIHKELLISVPLSKKGRLVGFCKDISLGYCSCHTIAFAAIQIAYSLKYARIICSGLDLTGSCSRFYDENKNPMPSELSRDLFKILPFFRFMHDNVKDINIYNLSDDTAISYDVIPFIKLQDISAEESKDMTRKKMQYRTSTDSYAN
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Miscellaneous:
MISCELLANEOUS: Present with 861 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MGSGDLNLLKSWNPKLMKNRKKVWETEQDLITEQQKLNTRLKEIEKERELNELLNESSKDKPETLKNDLALKKSGLEWMYQDAKLSDEKEDYLLGKKKLDSSILNQPATPPVRAATTISASGAATSISSQKKKSKLLKDDPMSKFKVTKQQRRTPDSTKKRAMSQRGKPLSKPAPDLDY
The following text describes a protein:
Function:
Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3. Responsible for LAG3 T-cell inhibitory function. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes.
Subcellular Localization:
Secreted.
Sequence:
EAGFQPVLSVLSLPSLRPQAPEDCPGQRRRLRAQVRALEQRIGQQRLQVEQLRGQRQHRAAEQSPNPAGQAGFADCAQVFNAGNRRSGFYRIKPLRSPSDFLVYCDMSEGGGWAVVQRRTDGSESFNRPWKDYKEGFGNTLSADGEFWLGNDKLHSLTSQGNYNLRINMIDFEGDQRFAIYRNFKVGDEQSLYRLSFGEYSGTAGDSLSGRYHPEVQWWAGHNGMNFSTYDRDNDRYEGSCAQEDTAGWWFNRCHSVNLNGHYYKGPYTAVSDNGIIWYTWHGWWYSIRSVVMKIRPAEFE
The following text describes a protein:
Function:
Confers resistance to late blight (Phytophthora infestans) races carrying the avirulence gene Avr1. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Sequence:
MADAFVSFAVQKLGDFLIQEINLRLSLRDDIQWLRNELLFMQSFLRDAELKQCGDQRVQQWVFEINSIANDAVAILETYSFEAGKRRPSRLKACACICSKEKKFYNVAKEIKSLKKKIMDISRKRETYGITNIISGDEGPSNQVTTLRRTTSYVDDHDYIFVGLQDVVETLLAQLLKEEPCRTVLSIYGMGGLGKTTLARNLYRSPRIVNTFPTRAWICVSQEYNTMDLLKTIIKSIQGCTMGTLGLLEKMDERDLENHLRDLLKERKYLVVVDDIWQREAWESLKRAFPDGEKGSRVIITTRKEDVAERADDRGFVHKLRFLSQEESWDLFCRKLLDVRAMVPEMESLAEDMVEKCRGLPLAIVVLSGLLSHKKGLNEWKKVKDHLWKNIKEDKFIEISNILSLSYNDLSTALKQCFLYFGIFPEDKVVKVDNIIWLWMAEGFIPRRGVERMEDVAEGFLNELIRRSLVQVANTFWEKVTECRVHDLLHDLAIQKALEVNFFDIYDPTSHSISSSCIRHGIHNQGERYLSLDLSNLKLRSIMFYDPGFHKMSLINFRSVFQYLYVLYLDILGATIPDVIGSLYHLKLLSLSCIHYLPSSIGNLKNLQTLVVVAGAYSFQLPPETTDLINLRHLVVRCIKPLVHINKLTNLQVLQGIQCDQWKDIDPVDLVNLRELSMSGIDKSYSLNNINSLKNLDTLKLFCGFDESFPSLEFVIHCEKLQKLYLNGSIEKLPNLFSNSITMMTLTDSKLTQDPMLILGMLPNLRNLQLKEAYFGKEIICSDNSFCQLQFLQLEYLRNLETWRLGTNAMPLIKGLCIDHCPNLKEIPERMKRVELLKRTSKWSS
The following text describes a protein:
Function:
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.
Sequence:
MNSPASETTVCSETPAAPISTTPYEWNELSLGNVRIGFPVVQAALSGYSDLPMRVIARRHSASYTICEVMLDQFLLSLTKREKTRHFLDIADEEHPVGGQLMGAEPEQFSAGALKLVEAGFDVIDVNFGCPVKKVLGRCRGGFHLSQPAVAIEILRRTRDVVPDHIPVTVKMRRGMDDTPESREQFFEILDGAIDAGLAGVTVHGRTVMQRYIGPSRWAFLKEVKQHVGDRLKILGSGDLFAAVDGLEMMRQTGIDGVTIARGAIGNPWIFQQSRALAAGEPLPPPPTIAEQAAVMREHFALCEETYTVERAPLLMRKFCIKYSQSHPDYREVRMAFTRLRTREEFEAALEQHYSADGPGQNVPRELHGSQEEC
The following text describes a protein:
Function:
Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MARAKAVDFFSTKNNSSDSEEEEDKPAVDPRFVLADSDSEGEEEQEDGDEDEEEKGRTSKKKTKDFFELAGKTDDGDDEEEDEEDEEEEEEEKEKKPVKTSSTKAKTKPMTKEEIEKHNKKIAKTGVVYFSRIPPLMDPGKLRMLLQRFGIVDRIYLVPEDPKAQAVRIRHGGNRALAYTEGWAEFTKKRYAKTCASTLNGNTIGGKKGSQHYDDIMNAKYLPKFKWSDLSEQLAQETHNRQARLRTEISQATRENQTYIQSLEKSKAAERRRQRQEEEGGETEEKPAKKVHRDFYQGKTHSARAKEGKKELDGSVGSILGSVM
The following text describes a protein:
Function:
Interacts with the SNF1 protein kinase.
Subcellular Localization:
Nucleus.
Sequence:
MAKRKYGRSYSLDDTDSCSNKVLIVPTGQSSSNAITDFSVRKAHACDRCRLKKIKCDGLKPNCSNCAKIDFPCKTSDKLSRRGLPKGYTELLEKEVVRLTNMNASSSANANSNLPFINDTFYCFDNYNTQSENQRFLGHLTWNILTNTFPTQKAVVFTDDRNNIDLQLQLLTNFLNLNGDFNHLPNFLLLKYDYNLQFLKNLLSVIIKDFFKRQNSLLLLLYPTNLWKNLLLDKINSTAMTGEPITLLALLYIIQFTWSCFDDFKLFKVTKLIVSLTTNSKLDLKVLQLVNLSIFYFMGASVDSCKSKSSLTEHSNVNSVIWTNDLLNLNFTNILNMGLYINPKNLIPISGNNNNNKSNEEDDRIVTFWCFQFLSSWWSLIQGLPKSNFLTEEFQPKSISVLEIPRLKPFEILLNFIIYSLDGCNLLNISSLNVSDPNFQFFQNELESFKKNLLLWNLYHNLSDHDNFRFLTSSSNKKLTTNLLLKNLTGLNHKLNQPDFVEIQLTLFYLSLKLMTLKEGDQDLKKEDISLEILSLYFLILTDDSNNDDNQQLQPQQLNLYHFTPFNSIDIIDLCLNNLNNWSLSLKYESGQNQPHSSKIKFEKFQNFLNHWCPIWYYDEFSTNPFLQILKINFKLLPFETIHYSQEEQRLLISLNKLRYLDAVSSFNSSSVKSNFASKVNTQLNLLQHSSSNSNFLDASPYDFNKIFMNNFENYDYETDEGYAEDDDEEDSDSDNSLPLEIPFKKSKNKCKNRNKELSQRLSLFENRDSNSVDFNTDTNLNLNPDSPSVTSSKKKYLDHIILDNRDIVSNHDSSKQKFKIQNILNSTF
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MERDKPCSFFRSADMSLCQLFLQSEVAYQCVAELGEIGSVQFRDLNTGDRLFVNQLQRCDEMERKLRFIESEIAIDGVKIHRSDLEDFRIYTPRLKEINGLDESISRIEKELIEINNTTRQLRESNIHLWETTQVLKKVGIIVAEDPDREVPDNAYVFVNEAELIDDEEGDVETGSDTGRELKRIAGIIPRSRLYGFEKLLWRICNGTVFLHSLDCEDGHPLFNESEDLAVFVIFYSGVQTGRKVDMVSRGSPVRIYKCPEKPQDRQALLNQLTEQLEALSDVLNRTFAYRARAVHAAAQTIHVWKIKVLKMRMVYRTLDMLARRTLSADHIQQYLIGEGWIPTTELDNVRDALSAGAIAAGSSMHPILNEMDSTEDMPPTHFTLNKFTSGFQSIVSAYGIADYKELNPAPWIIISFPFLFAVMFGDVGHGLMIFLFALALILFEKKFAAKRITDEIFSTFFGGRYIILLMGLFSMYTGFIYNDFFGRSMNLFGSSWATTANNNSCWQWKGLNEIEKWERQAAARNRTFEIMLDPIYCYDGNAIADSVQIGSWWSYVKYGFFSTIPHLMLDPVWDLAKNSLAFLNSMKMKMAIILGIMQMTVGLFLSLGNHLSKRAHIDVYFMCIPQLLFLASIFGYLCLQIVAKWVAFPAGSTWVFGRYYPGSSCAPSLLIGLINMFLQTNRKDGFGHFNTTNSKYSLGDTKPDDFIADFNCATAYWFPGESIVEKFLLGIAVLSIPVMLLGKPLYLWSRRPSSGHVNLDHAATHEEASLSEVFLFQAIHTIEFVLGCISHTASYLRLWALSLAHAVLSDVMWTKVLGLATGVEGWLGAPAQFVIALFFGFLTVSILIVMEGLSAFLHALRLHWVEFQSKFFSGNGVKFEPFSFEEKIRKMEDL
The following text describes a protein:
Function:
Acts as an E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Golgi apparatus, cis-Golgi network membrane. Lysosome.
Sequence:
MLGFRARCWPHPRATLVPHLPTCRSGRRCRQVRSRGCRSGHPAAAGAACALPWRRAPGLVARRQSPKALWILERKRLEPPTFRGSLAYYPSAKEAQDVSCQTPAVSGLRMAEQQGREPECPVCWNPFNNTFHTPKVLDCCHSFCVECLAHISLVTPTRRRLLCPLCRHPTVLASGQPVTDLPTDTAVLTLLRLEPHHVILEGHQLCLKDQPKSRYFLRQPRVYTLDLGPEPASQAGQPQDVGPSTRPVPIRSRYSLRECFRNPHFRIFAYMMAVILCGTVLFIFSIFCTRRFFWGVGGRLGCASASSKSPNTMRTSES
The following text describes a protein:
Function:
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MSQEPSSSFSDGFMESDFSQGSFSASDDAELSIPSEFAESVDELSSSSDNGDQGQPLTEPNNIPIDEDTVYNIWGQVVGTRRKDIGPDGSSLDMFLERHKDTNEFFRTVYDPAKGYKRANLTPEEEEMIRNVMVSRPYNDAPGLSRMNIQSTLVNKNIMRTALTSDIVGPKEKYASKAIVRKIEKLREGIERGEIVYDPNRYKVDENRGLVVGNRDLWADVDETEDPSMRIPKGRGEMYMNPTKPKLPGHALSYNPPLEYLNIDGDGSQQKLQSLRQIKTYTNFVKDQFDRCVTLYLNPRQRLRKEEDMDSMLPTLPNRSLLTPYPTFCAMTIRTGTRRINGLTFSPKGMFFAVGGRDCILRVFETYSGRQVRAIPVLSTKKLEKKSINFLNLEINCCKWCPRTDVSIIAVCAGDELIFVDAGICESGNYNEVRERTRFLLNARPETTQPCPHMAWEMHAGVTSGGKSYASGFVTQVSSNAYNEGSEDDDAAESARFNEERHQRGHEGQIDADVYTVYTRLNQFVLLRIHHTHLVSFCNWHFQGDYIVTVCTDDKSRAKVTLHQLSKWHSLSPFNRLKSKIIGAHFRTKKSELIVVSERSSRIYNLLTGDKLSTLYPGVKQVTASGMGYGDNFITGSADSQCALFANAAGPEPTAKLCYHTSTIRNIDVHPCGGLVATCSDDGIVQISRIVDASLVKMHPGQFDEKLYNRMIPCVVLNRRRQAADGSVGISRVTWHPRQPWLLCSGTDGVLRLFK
The following text describes a protein:
Function:
Single-stranded DNA-dependent ATP-dependent helicase. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair. When associated with KU70, binds to double-stranded telomeric and non-telomeric DNA sequences, but not to single-stranded DNA (By similarity). Required for the maintenance of chromosome stability and normal developmental growth. Plays a role in maintaining telomere length. Acts as a negative regulator in telomere homeostasis.
Subcellular Localization:
Nucleus.
Domain:
The N-terminal domain (1-265) is necessary for binding to KU80.
Sequence:
MDLDPEGLFRDDSDEDDDNVQEREANKEMVVYLIDASPKMFTPATKADEKEETHFHTIVNCITHALKTQIIGRSYDEVAICFFNTKEKKNLQELAGVYVYNVTEREPLDRPDARLIKEFSCIEDSFMSNIGSRYGITSGSRENTLYNALWVAQALLRKGSVKTVSKRIVIFTNEDDPFGGLTGAVKTDMIRTTIQRARDAQDLGLSIELLPLSRPDEEFNMSLFYADLIGLEGDEIVDYLPSSGEKLEDMTNQLKKRMMKKRKVKTLAFAITNDVCIEVNTYALIRSTTPGAITWLDSISNLPLKAERSFICNDTGALIQDPQKRFQVYNDKIVKFSTRELSDVKRVSSHHLRLLGFKPLDYLKDYHNLRPSTFIYPSDEQIFGSTRVFVALHSSMRRLGRFALAFYGNPTRPQLVALIAQEEVTSAGGQIEPPGIHMIYLPYSDDVRYPEEVHLTSDDAPRATDEQIKKASNLLRRIDLKNFSVCQFSNPALQRHYGILEALALGEDEMPDVKDETLPDEEGLARPVVVKAVEEFKASVYGENYDQEEAEAAAAKAGASKKRKALTDAAAEKSAAHNWAELADTGKLKDMTVVDLKSYLSAHGLPVSGKKEALVSRILTHLGK
The following text describes a protein:
Function:
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Also cooperates with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Also plays a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts.
Subcellular Localization:
Nucleus. Note=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin-remodeling and transcription initiation in developing embryos.
Sequence:
MELYETSPYFYQEPHFYDGENYLPVHLQGFEPPGYERTELSLSPEARGPLEEKGLGTPEHCPGQCLPWACKVCKRKSVSVDRRRAATLREKRRLKKVNEAFEALKRSTLLNPNQRLPKVEILRSAIQYIERLQALLSSLNQEERDLRYRGGGGPSRWYPVNATPTAPPAVRSGAMHWSLVPTQEIICSQLTLQVPTTCTPLRPSWTASRWRICLSPSQMKPCPTEIVCQAGCAWEPLSWCQTPPLLQQGPFKWGCPGAQKTALGCHKPDYPPSIHIRLTPSPAREFN
The following text describes a protein:
Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
Sequence:
MAHVREASRSSRSVACWSSGGGRGACLEQAAENASRMEQTMRGTQGAQEMKPELWPEPKPTSENLTSRGSGSDEKVLPSIPAACHTSSSSVCPRRKPRPRPQPRSRSRGGRGLKAPPPPPAKPPPPPPAPPPPPLPKPRPVAWRNSRRRPRPAPRPQTRKSYPSDPGCSGDSDGTENRLLEVGFDKGPTGCSHVEIFKVAKNWRRNLRMIYQRFIWSGTPETRKRKAKTCICRVCSTHKNRLHSCLSCVFFGCFTEKHIHIHAETKQHNLAVDLYHGVIYCFMCKDYVYDKDIEKIAKETKEKILGLLMSTAGDMSYQQLMASEVEENQSICESKEQETSLVKPKKKRRKKTVYYTVGLRGLINLGNTCFMNCIVQALTRIPLLKEFFLSDKHKCMMTSPSLCLVCEMSSLFQAMYSGNQSPHIPYKLLHLIWIHAEHLAGYRQQDAHEFLIAILDVLHRHSRDDGIEQEGNLNHCNCIIDYIFTGGLQSDVTCQVCHGVSTTIDPCWDISLDLPVSYTPGRAGSTGQKPRVISLTDCLKWFTRPEDLGSSAKIKCSRCQSYQQSTKQLTMKKLPIVACFHLKRFEHLGKQRRKINTFISFPLELDMTPFLASTKESIMKGQPLTECVPIENKYSLFAVINHHGTLESGHYTSFVRQEKDQWFSCDDAVVTKATMEELLYSEGYLLFYHRQDIEKE
The following text describes a protein:
Function:
Probably functions as a hexose-6-phosphate 1-epimerase.
Sequence:
MINKIFALPVIEQLTPVLSRRQLDDLDLIVVDHPQVKASFALQGAHLLSWKPVGEEEVLWLSNNTPFKTGVALRGGVPICWPWFGPAAQQGLPSHGFARNLPWALKAHNEDDNGVMLTFELQSSEATRKYWPHDFTLLARFKVGKTCEIELEAHGEFATTSALHSYFNVGDIANVKVSGLGDRFIDKVNDAKEGVLTDGIQTFPDRTDRVYLNPEACSVIHDATLNRTIDVVHHHHLNVVGWNPGPALSVSMGDMPDDGYKTFVCVETVYATAPQQATEEKPSRLAQTICVAKR
The following text describes a protein:
Function:
Involved in axonal outgrowth and fasciculation.
Sequence:
MAADGDWQDFYEFQEPAGSVRDQENCNASPEAGAGAHAGGDSFPALASSLEEKLSLCFRPTSDADPPRAAVRPITERSLLQGDEIWNALTDNYGNVMPVDWKSSHTRTLHLLTLNLTEKGMSDGLPFDTSDEEELREQLDMHSIIVSCVNEEPLFTADQVIEEIEEMMQESPDLEDDETPTQSDRLSMLSQEIQTLKSSSMSSCEERVKRLSVSELNELLEEIETAIKEYSEELVQQLALRDELEFEKEVENSFISALIEVQNKQKEHKETAKKKKKLKNGSSQNGRNERSHMPGTRFSMEGISNVIQNGLRHTFGNSGGEKQYLTTVIPYEKKNGPPSVEDLQILTKILHAMKEDSEKVPSLLTDYILKVLCPT
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MTAVLLAMQTVVLLPAMFGGAAETSIEAVTSPYHEVMYLEKLISNFKGKLSTARSRATALSNDYSLLTLAAVCTEDTQKAAAYIALSAETKEAELKQEAAIAAGEAQITELVKTLKARVSQTKALIHAERDAVDTQVATPATTTQTFLSAGTGEHCTIPTSRGPSTTDSCTEAAGSGTHIDKAVVELQEIENIKLLKDERFLTPEYELIVAAQGNAGTGGPHRSYKKGACATSGDSGASLRSLTVALGVKSITRKKGEDEDPAKQSLFKGQGAGSGCVDADTDSKSHLTTQKKVANAICRHRGADIKLYERPLLKSKTTLANEGNLRALAQLLATGKVNTKEEATSQTEAVKALLPAGESTLTADLVDPLATEEITYDNDNNPVKTTIKDTNKPGKFATTLAFSYSRRQRKKSAITAQKEVSDTKKEKCKEDTEKSKYIADTDCEHKDGKCKLKEGVNMENDGKTTNTTGNNSFVISKVPTFLAFLLL
The following text describes a protein:
Function:
Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP).
Subcellular Localization:
Membrane; Single-pass membrane protein. Nucleus. Note=Localized primarily in plasma membrane or endoplasmic reticulum membrane as dormant form and, upon specific stress or signal, is processed into a transcriptionally active and nuclear form after a proteolytic cleavage through regulated intramembrane proteolysis (RIP).
Domain:
The NAC domain includes a DNA binding domain and a dimerization domain.
Sequence:
MNQIKNKTLPEMTTEQALLSMEALPLGFRFRPTDEELINHYLRLKINGRDLEVRVIPEIDVCKWEPWDLPGLSVIKTDDQEWFFFCPRDRKYPSGHRSNRATDIGYWKATGKDRTIKSKKMIIGMKKTLVFYRGRAPRGERTNWIMHEYRATDKELDGTGPGQNPYVLCRLFHKPSDSCDPAHCEEIEKVNFTPTTTTRCSPDDTSSEMVQETATSGVHALDRSDDTERCLSDKGNNDVKPDVSVINNTSVNHAETSRAKDRNLGKTLVEENPLLRDVPTLHGPILSEKSYYPGQSSIGFATSHMDSMYSSDFGNCDYGLHFQDGASEQDASLTDVLDEVFHNHNESSNDRKDFVLPNMMHWPGNTRLLSTEYPFLKDSVAFVDGSAEVSGSQQFVPDILASRWVSEQNVDSKEAVEILSSTGSSRTLTPLHNNVFGQYASSSYAAIDPFNYNVNQPEQSSFEQSHVDRNISPSNIFEFKARSRENQRDLDSVVDQGTAPRRIRLQIEQPLTPVTNKKERDADNYEEEDEVQSAMSKVVEEEPANLSAQGTAQRRIRLQTRLRKPLITLNNTKRNSNGREGEASHRKCEMQEKEDISSSSSWQKQKKSLVQFSSVVIIVAVIVVLVEIWKESRDAKCSFLFHQLDSFKGMFT
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MASPEVKLFGIWASSFCVRIELVLKLKGIACEYTEEDLSNKSQLLLQLNPIHKKLVICCDNILASEGKEQEKAVTEFTNSLEVLDQGLLKDFRGGLPVFNGERRGFSDLVLSCSSGWHKVLEEIAGVKVIEAERNPTLYSWRSHFFELNVVKDTFPSHEKLLSYAKNKREKVLHIDTSLA