lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Regulator of the GID E3 ligase complex. Modulates both assembly of the substrate receptor GID4 into the GID E3 ligase complex and its activity toward its substrates. GID12-binding remodels the N-degron binding pocket in the GID(SR4) complex, and could limit substrate accessibility of a bulky substrate to a ubiquitynation active site, thereby stabilizing gluconeogenic enzyme substrates. Involved in actin patch formation (Probable).
Miscellaneous:
MISCELLANEOUS: Present with 339 molecules/cell in log phase SD medium.
Sequence:
MATGRIQFAVSTPCNTKGKPSGYRLFEFKNDRLALVPSERGCTKVDVNANIQAFCYLRPNGRDTSISPDATHILDSCDYMVLAKSNGFIEIISNYQYKIKNGLRLAPSYILRCTPEDFESNFFSDYMIAGLEYSQGLLYCCMCSGRIYVFVMNLPTDYIQYKNMYNPMFPDCFFKVHHDNNTTHSSEEEKLFEGSTRYTGRSCSKHICYFLLPIEPSHLRSSPVVSSFCNMYQGLPIYRPSMYLHIERGISTFHINPLDRFCFMTVSPRSPLFIRKIILPLTYVTFLSTFISLKNSIQGDTCGEILSWDNVAQQNGFGSLFSWISNKFTFDTDIINSTIWDDIVKYSGTGMLDSGIVWKQRQGHAKDDIYELFHTQDMLGSSRRNSSFSTASSEPRPLSRRRRESFQALTRDAFRERMDVPCSTKWELDSFIRGLRRNTFMVDFEIVEKISHRNGNDGVNEDDNTTDESDETMTSFLTDNYKKMDIVCIDHFVTLSAFRPRYYDEPIIKIDSLSNKNGSENGTNEEEWAESQMKVDGQVIDDETAQFKQALGNLCSFKKLFMLDDSLCFILDTHGVLLINRFEIKNTKNLLRNSKDTIRIIPHDFGLINDTIVIINDIDVGTDNVCALTFHLVVTSMAGEITVLKGEFFKNCRLGRIKLCDSLKLNRKDRFVDKLALIDYDGLNAQKRRLDYDEKDLYTFIVKKVKRD
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Sequence:
MGKKRFYAVAVGRQTGVFSTWEECQKQVSGFSGARFKSFLTLQEAQAYASGVQDVEPGSVGTSLVADSHTPVLVGVKRALSLDVTLDAVEVDAADDGNEVDDESKQQVLSPEWVEARKREAVVVYVDGACRNNGSRSRERRPRAGFGGFYGDGDSRNFKFPLPAHEPQTNQRAELSALIHVLRVALDSHPCYNLCVYSDSKYTVMGVNSYLHRWERNGFKTAGGGDVANIDLWSQLTKLRNRHLSRCAERFTMEFRFKASLAAIAARAVALQLKHVPGHAGVYGNEMADRLAVEACESPFG
The following text describes a protein:
Function:
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
Subcellular Localization:
Nucleus.
Sequence:
MAGRGKRKNRDDNGFAEWGGYMAAKISKLENQYLNEQFNEVQEDDKLSNVFSNVAIFVNGYTSPTAEELKRLMLANGGVYHHYYNSKTTTHIIASNLCDAKIKKLKGDEKFVKPEWIVESLKANMLLDVKPYLLYTGLTLDKGQQKLDIASIQKKNDDNQTAIERKIDEAQSSEPVPPGDITRHSREMKRAGEDDFLSEFYKRSRLHHISTMGACFKRYVTELREKSDGVFPGLESIENWKNLTGCLGNHKCEETVFMHIDMDCFFVSVGLRNYPSLVGKPVVVTHARADAKPLPRREGSNREYEFDCYKEHWIKKSKFSENNSNAVETVATVSDVFPRLQDLDETCSMSEIASCSYEARAAGIYNGMFMGGALKLCPNLVAIPYDFEGYKEVSTSLYNTVAAYTLDLEAVSCDELYADITSVLRQSGLTPAEFATHLKDVIFNKTQCNASVGMGPNMLMARLATKKAKPNGLFYINKKDMTEFMKDHKIEDLPGVGRSMAHRLHGMGVRTCVEMQQVCVSLGKLQQEFGQKQGQTLYHMCRGEDKRALKTDHVRKSVSADINYGIRFANDQEMHKFVQELSIEVSKRMEEIHVRGKLLTLKLKIRAKDAPVETAKFMGHGVCDSISRSTTLCSATRETKIIEKEVQILLKQLKVDCCELRGMGIQFSKLVEDNVSKGKQPIQNSLLNFVARSRIVPPEEVVTTVADVTEPEREILEPASSKTIDKEKKDDAKETQHPPSLFELPSASQIDSAVFNELPDDLKNDIIQEYQRKGIALSEVNSFTIKPTTSSAVNGSSVPTSNSAATSRSENPVSYDGIEEVADIDASYWSALPDDIKTEIERDIQQRKAEATSPVKGWKSIFKPQRSPAKATSKLGSGKTKPEMKRKTKPNAPPKAKIQPIVRAPIAAAVPEEKKKVQVQPPEVLKEELGLSGATSLPEIRQLLIEWFSSTDVPENEDCEAVSSFLASLVNNKELHKIEPIILFLKRRGSDINDSWKRAIEDIINNTQLYVIQHYNAPLKLPSPVS
The following text describes a protein:
Function:
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MGISEATLFPLFIGLLACLAVNVIALKVNKDPQQQQQQQHQQRSHSGGPLDRTGRAGGGGYTSANDDFGYISDAMLPDVHGDGAGSPLGAAVSKGAGSASGVPPFKSDVSTSLPAFSGTVTNAKSPFGADDPDEEEPDDDEDDGYEDGGELLGNFDEDSRATEDRGPSGHKHDSLDYTDNFEVAAIDQIESFGAGNDGTPLPVFLVEPKGAYVMKNRPAKLYCKASHALQISFKCSGSTKPPPTEKEHHTDPHSGVQLQEATATITRELVDEFFGKGPFKCECRAYSSRGHVKTQPVTIQVATIKKQISISPKIVRVATGGRAELNCIANATPAAKVVWLKNSVPVHANPPFVLLTENALLIARVEIQDMANYTCVAENIAGKRVSDPVPITVYVDGGWSSWGPWTDCKCPGHGKQGQKRTRVCNSPVPMNNGAPCKGASTESTPDCLPCSAGRWSSWSEWSECGPDCTQIRQRSCVGSSSATQLGSVPVTSAALVANSSSAQAFAIDSGTIVNCAGKSQQSIKCTGGLCNYTAQDSNWSVYLWVTLVAAFCLGVVFAVSKFLRRKKTIPAYNLARSEMPTEYFANESKKLTHFQPDLTQNTGPINYEYPMTASLQPHLAGHHPHHHHLQQQQHHHHLSSLHHQHGSSLLGPVATGHGQLHPQCQSQQAPTLPIGGLKSSLPLPRSNSEHHYDVPHLCNNYIYPLDKVSINESYSSSTYSKRVCSVESLETSTNTSADSTYDQAPMLPPSTSPAIRPTTLVEEPFRGAEVTHATLTPAGALLRLATYSTALLIPEGAIPKHQRHSVALSIVRDDKHHVPVPTGPRSTYLSPVVFCGPVDTKVNKPIVMQLPHCAENLSDWAFSLYSAPDNVTPWCKVVTIGEETLNTPALVQIDKRYAYVLTETFGKYVLVGESATDIQERVACKRLRLFICGPSTVPEFSDVSLRVYIVEDNPGAEERCRHCEQEIGGVLLGRSTVLHFADVGQAGLNIDLQCVGGWRAKSSSERQTIPFSHVWNSACTALHCSFTLCRTEHDKCDFKIVVQASQDVPQGLDERLTAIGVPATLSISSFVPMAKDGRHCQHSSSSFETMTICSVGSGDHNTNLVATDRFRLSKDVKRKLCRCLDPPTQKRNDWRMLAAHLNVDRYLTYFATRPSPTDQILDLWECRNRDLNALQQLIEICRTMERPDAVAILEQIQPAAPWV
The following text describes a protein:
Function:
Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.
Miscellaneous:
MISCELLANEOUS: The homologous nature of GLIC to eukaryotic nicotinic acetylcholine receptors and other eukaryotic pentameric ligand-gated ion channels, and its sensitivity to general anesthetics, define GLIC as a structural and functional model of signal transduction in the nervous system, also relevant for exploring the molecular basis of anesthetic action.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
Consists of an N-terminal ligand-binding domain that encloses a wide aqueous vestibule and a transmembrane domain that forms a narrow channel.
Sequence:
MFPTGWRPKLSESIAASRMLWQPMAAVAVVQIGLLWFSPPVWGQDMVSPPPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLSLSWKDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNLPKTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFLLANIILAFLFFGF
The following text describes a protein:
Function:
Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQRTGDGERPRFFQQDLDVIPDDKGSDLFIQTAEGPDGHVDDEVIEDKTRFITNLKEVLGALPDDILEGYWNSYGASKDGLSKAIQQHFEGKETKGCSDAHDDLNTETQNSQNTIVNGHVSNQIKRASEGGLPILKRKKQLCCWRRFLGSTQVNAMATRPTAQPLKYGSELLIRRTSGQPNNSGLRSRKKPGFSQYVRFCDATSSRELGRLPEDISEILHTLLQTPGVEFKATMIFCNSKRLSVGDLFVVRLDCFVTSLLFDPALPGKAEDEQFQQRNRALMLLFKNLNMTPLAEGADLVPEKPEFYDLEEDESITDATVNSPTASDDYMDLNQLRNFYRSTQESASIFKLRETTPPVDKFQLELRRYQKQGLTWMLLREREHAILEPGSQDALADGPMDPMWRMFKWPRDTSWDVSRGTTYVSLEADIPDKFYANLHTGEFSLVKPISKSILKGGILADEMGLGKTISILALITMVPSDTKHLLTTAQEKPPVGHLSLELGISTVKPYTASTTLIVVPMSLLPQWRNEFVRVNDGNGLYCEVYYAGNVSNLRTLLVKQKSPPSVVLTTYGVVQTEWSKLQQFDYEASNEGLFSVEFFRIILDEGHNIRNRTTKTSKAVMALTSRRKWVLTGTPIMNRLDDLFSLIKFMNFEPWCKIDYWRQFVSDPFEKKDYSSALEVIQAVMGPILLRRTKNMKDEDGNPLVQLPPKEVVIEMIRFSDTEAGLYKYFLSKAEHSVKESLARGDLLKKYSTILLHILRLRQVCCHFKLLGSQDENDEDLKNMKLINDIPDISTLLGEDSQSPGSSSEGMPDFIEDFKTKYPNSDALKDLECSICTCEAISPLTSVVFTRCGHPFCESCLLEYIQFQNKKGSETICPNCRAAVESRYLLKLEDINGKLEPVPYSNTKKSSKIVALIRHLKHLQDTSANEQVVVFSQFSSYLDILENELRQSFASDICEIYKFDGRLDLKERSNVLAKFTEKSLVKMKVLLLSLKAGGVGLNLTCASHAFIMDPWWSPGMEDQAMDRIHRIGQSNTVKIYRFIVENSIEEKMLRIQEKKRSLGEFVDADEEERRRSRIEEIKMLFA
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Subcellular Localization:
Cytoplasm.
Sequence:
MLSIINKHQKFKNLSKQINNIYFNQNLIYNNIYENNNNKLYYSNSRSTLTLTSTLTSTSTSSTINKKQIKIKNNGETIKINNYGINKFIEEFNYPYDDILAATTTINGGGGGVDNLMVQPKTSYKDKLEVFEEVLSISMDEAGKGALLGPLFISCVVLDDESEKYLKSMGVTDSKKLSPKRREYLYDIIIEHALYYQTIILTSEKIDQRRELHTMNQIETNLFYQLIKDSINNLPKNQQCKIIIDSIEMNTQKYSQPFKMEFPPPLYQIYCETKADHKFISVGAASIIAKVERDRWMKQLETNTSHIIGSGYPSDPLTISYVNNFFKKYYVYPNSMRKSWKFTGADKEFDNLSSTLDDGNNKNIIDQDDELLSLIHKQKERENNLLNLELQQSFSSSSSSSSSPSNINSLTKKEQRELLKKEKESLKLEKEALKLEKENKRKEKQLERERNKQNKPPTTKQILDLLLLKLNNLESKIEQIQKKQEIIDNYNNNNINSNNNNNNNNNI
The following text describes a protein:
Function:
GLC7 phosphatase-regulatory protein involved in GLC7 subcellular redistribution and chromosome segregation.
Miscellaneous:
MISCELLANEOUS: Present with 227 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MVDVQKRKKLLAKAAASASIPAIKGSVPLDSYDIKIIQYKNALYKLNELNRLLNVLVPHLKKKRDNDESYKIIPLVNFILSLCEGPIFNVSPVLAKRYHLLCRFQLIKLSEVQQRLSTNFIDVEGWMFPEEVPLDHYKSCIYNNSLQWKILNSLSCIAQNAIKIYNAKLRQILLERDAYKARSLPFDTSIIEDLLNPVEMTLILDLAVLINDPVRDKSTHSFYKLQWQVMEKLNSCVHSKIFPILRTYYNQLQKFSETRPTSLSNLQKDLPHWEWTLHRIYTFHLRVFSVLCVIISFSRQIFLPNKQHFLDIKTRLSSENVYHYDLIICELMALLSPECDDVTALFELQENLKFWTQTARTDNNSSRTPIFHLQPGLVVELFNNHICKIIPKLRSIMGLLSNWMDCWKYIEKNYKTFDETNDLRENLKEKLERDKALYLEVKNAKSKLKKKPSITKLPASSSPSPSPTSSASPSRQASLESIRTRARAHLASNSSRSPSVSPVRTTFNNKNAETKKSVVSPEKRKLINGRRPRSSSLQSYTNKQQTSYLNSTRHPSIAPPSKLNNQRSNSLQSSTMTLNQKIVQDTVRHLMNKSASTPNPSASSSLAPSPKVSSINNTSSGKSSSTLIANSSDTLAIETLTLDPESNSSELSIKRVRFAGVPPMTEAENPKPTKVGWYKKPAVLHYPPIPASAMIKPLQHKSKYNTLRQEEGFTFRKSLRDGLEWENGESGSETTMMPFGIEIKESTGHRIASKIRSKLR
The following text describes a protein:
Function:
Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MVEGSSAGGSAERSSRLFAKYASIISAGPAASEGVECGASGATGSASTSSSAAPTRPQPTPSSCSYAAAASAPPPGPLPPTSGSCPVAAPSPVSTPSTGSSSSTRTSCSAAAAVADGGTLNPLNNMPNSLAATPAPVPGLRGERVVSSIPMAPPDKLPPHQAPGQQNWVYPSEQMFYNAMKRKGWDPQAEDMRSVVGIHNTVNEQAWHQVLAWERLHCDECATPRLKRFQGRPSDLSPKARLLNFVGFGLPFDRHDWVVDRCGKEVRYIIDFYNGAPQPGQSAAAAFFLDVRPALDSVEAAWDRLRMQFSWVASGRWRE
The following text describes a protein:
Function:
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
Sequence:
MISDLISKLQEKTDLTYDEMNQVMTDVLSGKTTDSENADFLSNLTDKGETDDELLGMLDKMQEFSLKIEPKNTGTIIDMCGTGGDKLQTFNISTTASFVVAAAGGVVAKHGNRSSSGISGSADIFEYFGYDLNLEPPKIAEILEKHNICFMFAQKFHPAMKHVSVARKQLGKRTAFNLLGPLSNPAKVKNQLVGVFSIEYLDRLPLILKRKGAQNIMTVRSDDGMDEFSTSSTNRVCVLRDDKVLMNAIDPEVVGLHKSSLTDIQIQTKEDAIESFVGVLNNTANQAMIETTALNAAGGLIVANISNNFEEAVELALNTIKDGKAFSLLEKFVQDTGDISKLKEIADG
The following text describes a protein:
Function:
This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated.
Subcellular Localization:
Cytoplasm.
Domain:
Does not bind DNA by a helix-turn-helix motif.
Sequence:
MAEWSGEYISPYAEHGKKSEQVKKITVSIPLKVLKILTDERTRRQVNNLRHATNSELLCEAFLHAFTGQPLPDDADLRKERSDEIPEAAKEIMREMGINPETWEY
The following text describes a protein:
Function:
Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
Sequence:
MYDLLVQRADVLQIANGVPSVLPQHDIAITDRRIVAIAPDISPGLARETLAADGLLAIPGLINSHSHTAMSLFRGVAEDVPIEEWFNGIIWPLETNLTPEDVYWGTLLGLAEMIEAGVTCVADHYFAMDAIVQAVQESGMRALLAWTIFSGADEHEQLSQARQFVEQWHGAEADRIRVWMGPHSPYTCTPSLLRRVAQTARELGVGIHIHLSETAAQVAQSLATHGCSPVSVARNAGLFDVPALAAHVAHVSPEDIATLAAHGVAVAVTPKTEMKLGIGVAPTLAMREAGVTVALGSDGAASNNTYDILESARLLALLEKLRQSDARCMPIGTTLELATGAGARALQWDGIGVLQVGARADLALVQCATAHTQPLHNPAAALLYSSQAADVDTVIVDGRILMHRRTLLTIDKPRVLREVAARIERLTQRQGERRIATYPEAQASR
The following text describes a protein:
Function:
Transcriptional repressor that is an essential upstream regulator of neural crest determination and mesoderm induction. Functions by recruiting the transcriptional corepressor tle4. Also acts in a negative auto-regulator loop by inhibiting the transcription of its own gene.
Subcellular Localization:
Nucleus.
Domain:
The C-terminus is required for transcriptional repression and mesoderm induction.
Sequence:
MTLSSSGSASDMSGQTVLSADDADIDVVGEGDEALDKDSECESPVGHHDEVDALGGKEIPRSPSGSSTDAEGKGESQQQQQEGIQNKPKNSVVKPPYSYIALITMSILQSPQKKLTLSGICEFISSRFPYYREKFPAWQNSIRHNLSLNDCFIKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRQQQDTLREQTALMMQSFGAYSLASPYGRHYGLHPAAYTHPAALQYPYIPPVGPMLPPAVPLLPSSELTRKAFSSQLSPSLQLQLSSLSSTAASIIKSEPSSRPSFSIENIIGVSAASSVAPQTFLRPPVTVQSALMSHQPLVLSRSTAAIGPILSVPTNLISGQFLPTAATAVAKWPAQ
The following text describes a protein:
Function:
One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins.
Sequence:
MDHVALLKQFVGMCQANPAVLHAPEFGFFKDYLVSLGATLPPKPADKPEGKCPMSEEPKKETPAAEATPEPEIPKPEEIPFPKIDNEGVIEPEEAVALPMGDSAKEATEDEIEKASEERGKAQEAFSNGDFDTALTHFTAAIEANPGSAMLHAKRANVLLKLKRPVAAIADCDKAISINPDSAQGYKFRGRANRLLGKWVEAKTDLATACKLDYDEAANEWLKEVEPNAHKIQEYNRAVERQKADIELAERRERVRRAQEANKKAAEEEAKRQAEQGDDFDFEGGFPGGMPGGFPGAGGMPGGFPGAPGGGAPGGMGAGIEQLFSDPEIAAAIQDPEVLPALMDIMQNPANMMKYINNPKVAKLISKLQSKGAGMPGMFGGAPPSAGGGCEDADCGGPCPGARGGASVPQQPPRRAPEPDLD
The following text describes a protein:
Function:
Catalyzes the exchange of ADP and ATP across the membrane.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDRTVWTDVRHFLERNCNLAAMQELKVILYHEIFGSSSTFINIKDPALQLVEYGLAWLTNESQLELKNIDDFFSGRKQRWIRLEEPAVLRVLYHHFMTDSNSCQDMLISKGQGDHSKIGLGFEKLAAFGAAQELDGKLPAEFVREFLHQENKVLLRNDTFKVPGIYFETAKLERPCTGVDMEVTICVEKHAHDSSFPTVLLTGNAHWTGHLFLGQLLWASARPLRVTNEVKKACWHSSGRYSPNKKQKIEGAMQLLCGVIGAGGGSMFLKEWLVDTTWQMKNEAVPGMIVLCQERCCDLKGNFAASFFLGWSITIAAGLASRRMMMRSGEGAKYKSSMHALREIMAKEGVKSLFKGAGANILNGPDVKRRLSGLPSYT
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42.
Subcellular Localization:
Nucleus.
Sequence:
MDEFNEKSKLFQDWLIKNNVEISPKIAIHDYCDTNQGRGIIALEDINPDEMIFKLPRSIVLNIDNNSLIKSYPSVLKKLRVLDQWIGLIIVLGFEIKFKFNPSDNNDNHNRSFWYEYLNILPDQFNQLIYWNDEELNHLQPSCILDRIGKENNLNMYNQIISIINQDLSGVEEFKSSPLTFEEYNKVATIIMSYSFDVEVPKSKKMTKNGTNEKGNDEEDEEEDEDKEDDDDDEEEDNEYYKSMVPFADTLNADTHLNNAILIYSTDQLIMTCIKPIAKGEQVYNTYSDHPNSELLRRYGYVELNGSKYDFGEIPLSTIKSVFIDQFNKLSTNKNKSNGDTFMTKQKFDELLQLINQLQIKKSIEQDGLEEDEAEELILDSYDCFNSGDVIIELVFLIQVLSTILVVYQYEQQQQQEKDTDKKKEFEIDQNLINRIFNKIYQLIESKKITSKCFEIYQSIINARMSQYPDIAKQPFNGNVAAANSEDETINSIRIYMAEVVLKSEYQSLEKCSSTIKDFKIINDVKLNKNILKKRNNDTNGVSETNNKKSKN
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MSGTKSGATYLIAVIKSLSISGGDKHHRDDEKARLESEFTACDDKLERLIAENYDQLQAALQAFTGIRKHVTDSLETVKQLKSKLIACKELLSYRREDLFKPWMDSVEEKQKIKILDKIDKIRSTPEQFDKYVAEKRYLHATGLLVTTLESLDGQLKSIEGLRELKAELRTRKEKMHETLIEELSNQIYGMEDLLQSQPEDDGEYFVNVIVEALNLLGKIPDAIVTIESRIKREIQMIIKKTKAQISDNPRYKAMSAGDAQILLEFLNLLFKKFCAVTKAHEVAADAIDKSLSGSNVTQNENIAVYRVADVWSEMQYAVQNILNQYLDVTNTAASLQIRAQTYKEASINVAEYYTQQGRFLRTGPKPQKKVAPLILLVKMSATGPLFRFDNSSHAITMSSYLMEKKLQDPIAAMEDYDVDIKLPCTPHANHINAVYKGLCSFIAKAEENLGLKEGNHCPLFLFVDAFISDIYLRKIQLQVKEKIDSVVKGVNALKNMIDMHTQKLLKLARPILHSTVVIHTVIHDLVDMIHDLPRYCPKIVDLLLEVITNYRDVIAEIYNGVLRFASDGETKVISAKWAKDAYISNLLKSLPSWKNIMSAYSEETNVDDESVTTDRNQQESEYLSNNLSSEMLQKEEILSEYDDLRMLGNLHESLVWFSDALLSFCDVLKHSIPKNTSESQKLNQDETDYFYVIINSSLNKLSEDFKEISETCLLVLHLEVRCHCFFYLSRATKISSYECTVDALDPDPLVIGLNKDLARIEDTMSTCLHPNKLRCRNIFALQQNLNNITLSREIALDRCRQYYELLNLSTDDIIQCIIDKGRLYKDTEYINLLTLQSRRTSFSGRRDFKAKIKRLQEVLKEIA
The following text describes a protein:
Function:
Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MAGTRAPWMLENFIDGKFLPCNSYLDSYDPSTGDVYCRVPNSGKEEIEAAVEAARAAFPGWSSRSPQERSQVLHRLADLLEESLEELAQAESKDQGKTITLARTMDIPRSVQNFRFFASSILHHTSECTQMDHLGCLHYTVRTPVGIAGLISPWNLPLYLLTWKIAPAIAAGNTVIAKPSELTSVTAWMMCKLLEKAGVPPGVVNIVFGTGPRAGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLEECVPTTVRSSFANQGEICLCTSRIFVQRSIYSEFLKRFVDATRMWKVGIPSDPSASMGALISKAHLEKVRSYIKKARLEGAQILCGEGVDKLNLPPRNQGGYFMLPTVITDIKDESCCMKEEIFGPVTCVVPFDSEEEVIQRANSVKYGLAATVWSGNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGVGREGAKDSYEFFTEVKTVTVKH
The following text describes a protein:
Function:
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGGEATASEKELQEREDQLSQQIQDEIVMGCVVNLALWPVLLGAAAYVAYKYNCSWVPYPFIDEKFHVGQTVRYLAGRWREWDSKITTPPGLYVIGWAVQRTVGLLVGWNTLSLLRLSNVIGGLVVWPWFVLRPLYFFNALAFWPATLSVFPLLTSYYFLYYTDVWSTILIVGSLTLAVTVPFGERASIWASAICGLLSCLFRQTNIVWNAFVLVVVLERRTMIHKGFNSLRINNYLKLIIHGIENWNSLVLPYAVNFALFLIFLLYNGSVTLGDKSSHVAGFHLVQMFYCLLFITFFSVPVWFCRSFLLNYVSRTVVYPIWTIFEILGIMMIIRFFTVVHPYLLADNRHIAFYLFKKLIGRNRFLKYFVMAPIYHFSTFVYLEAVRPTVFFFHPILPIEVKSPVDLPLQFTHISWSALIICTLLTVVPSPLFEPRYYILPYIFWRIFLLVSPEPFFAVPTEMTYRFGNTRRLAVEFLWFILINAITIVIFATNAFAWETEASLQRIIW
The following text describes a protein:
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl diphosphate to proteins having the C-terminal sequence Cys-Ile-Ile-Leu or Cys-Val-Leu-Leu. Acts, among other substrates, on Rho1 and Rho2 and CDC42 proteins. Participates in a RAS-like C-terminal modification of proteins involved in nuclear division and bud growth. It is involved in bud positioning and cell polarity. The beta subunit is responsible for isoprenoid and peptide-binding.
Miscellaneous:
MISCELLANEOUS: Present with 3940 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MCQATNGPSRVVTKKHRKFFERHLQLLPSSHQGHDVNRMAIIFYSISGLSIFDVNVSAKYGDHLGWMRKHYIKTVLDDTENTVISGFVGSLVMNIPHATTINLPNTLFALLSMIMLRDYEYFETILDKRSLARFVSKCQRPDRGSFVSCLDYKTNCGSSVDSDDLRFCYIAVAILYICGCRSKEDFDEYIDTEKLLGYIMSQQCYNGAFGAHNEPHSGYTSCALSTLALLSSLEKLSDKFKEDTITWLLHRQVSSHGCMKFESELNASYDQSDDGGFQGRENKFADTCYAFWCLNSLHLLTKDWKMLCQTELVTNYLLDRTQKTLTGGFSKNDEEDADLYHSCLGSAALALIEGKFNGELCIPQEIFNDFSKRCCF
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MPNYYLADDTKYTRPSTSAMSNLTELCGLKGLADSMARFDPVTGEKNKLRKSYKNQLLDLTGKFDIPSQPSLVRIIRDPVLAETGGKSLSVFDRDLLSRGLDFDATPSTGIPGFNPAMLGMPGPGKPGIGPQVGGNRLLSVRRSYNTESARESSNNEETPMARRKRKGDDDTDGERRRKRK
The following text describes a protein:
Function:
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.
Sequence:
MTPGIHTKPSLRATLIGAGVMASLMLFHLYLEYQPSLFLLNHDLRGGTRVIQDPRSPRTLLNESSPARGWLEVEYPAGPIEPLEYTRLPAIKGPNNWTCLLLHGLGDHQASDSFRLREALLTLRPALFEPMSFVIPAADALPVTVFPGLPRPAWFDIRNWSDIHRDEDVLHMENNVRRLVHIINLLQLDLSRTIIAGFSQGAVMSLLLGLTLDRPPAGVIMLSGFLPMPDQLEAIFSRPITETGIRRQTILHWLHGAEDPYFPLPFAQQGFRRLQKLALFPPHNLFFSHINRLDHRWSLEELGLLANSSLDRFFPTAPSSS
The following text describes a protein:
Function:
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression. Required for cortical neuron differentiation and callosal axon elongation.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MMKRTRVDEVQFGTRPVPQTSGGVGVGVVGVTGGGPTSGGGGTATVGVNTTGVTIGTVVPSAHNATISGIGSIHHRILTPQHGGAQTIAYLPSTTPTATNLKTTTSIVDSTTAGGPVGAGAQVAVGIGSAAGGRSVVVSTGSTGTQTLQYTTSYSVASIQAGGTLKANTADGANTVQIHVTGRRTANNPASAQTVSSSSQTGTIRQRTISGTQTVATAVGNLATISQQQPVQQSPLGKAQTPPSSVVANSIPVGGTTPPQGQSGNATPRLKVEDALSYLDQVKYQYADQPQIYNNFLDIMKEFKSHCIDTPGVIERVSTLFKGHTELIYGFNMFLPPGYKIEIHSDALGCSVPVVSMPSPPGAPTSTGTVHMLTGNSSMSGAGHIAIKTTNAATLTPAAGAGAAAAAAAVAQIQSAGAVNLMTHGGASLTQTTIHALQQATPPQSQSPGGGHVHVSVTAANAVVPGQPGISVSAHNVPQNYSRDRERATITPTGQMAGAAANVNASASIVVGGPPTPNSLSELSPHGGAGGGPGAGAAQHNLHHIQQAHQSILLGETGQQNQPVEFNHAITYVNKIKNRFQNQPAKYKKFLEILHDYQREQKVMKEGSLNQGKMLTEQEVYTQVAKLFGQDEDLLREFGQFLPDATNHQSGQYMSKSASVHNDHGKRPTATLSGGAHITMSSASPAPSGSPLHLGATTLPQIDKSAHAAAIGNLSAVNTSVSIKTYNNNQQQQNHVIGSGLNATRNDILFEKDYHAGLQQQAHQRGAGVGGHHHLAGTAAGANIGRPGVGASVMVSYDKEHRNNHHVQKYVGHAPNQNLTHGHNAKKSPSYGIPSVIGSMPHISDNSLDRSSPGISYATPPLPSGPHGQHNSGSATRRPGDDSLVGHYASGAPPAKRPKPYCRDVSFSEASSKCTISDAAFFDKVRKALRSPEVYDNFLRCLTLFNQEIVSKTELLGLVSPFLMKFPDLLRWFTDFLGPPSGQPAGGLIDGMPLAATQRQGGGSSNSSHDRGTSHQSAAEYVQDVDLSSCKRLGASYCALPQSTVPKKCSGRTALCREVLNDKWVSFPTWASEDSTFVTSRKTQFEETIYRTEDERFELDLVIEVNSATIRVLENLQKKMSRMSTEELSKFHLDDHLGGTSQTIHQRAIHRIYGDKSGEIITGMKKNPFVAVPIVLKRLKVKEEEWREAQKTFNKQWREQNEKYYLKSLDHQAINFKPNDMKALRSKSLFNEIETLYDERHDQEDDAMEPFGPHLVLPYKDKTILDDAANLLIHHVKRQTGIQKQEKQKIKQIIRQFVPDLFFAPRQPLSDDERDDAFPFLVDDNTKMDVDSPLGRTESSTRNAKSTPSESASPARSNASTSSVTPAGIKKETDDSKATTGSFAPASSATASSATPVDDATPSTSSAAAAASAASSSTVSGTEGKPKDDPLSSHKEEGAGCTSSGVATSPRQAQDTAGAGVDVEIKLEHPADFSNPKLLPPHAHGQREDESYTLFFANNNWYLFLRLHAILCDRLHVMYERARLLAIEEERCRVNRRESTATALRLKPKPEIQVEDYYPTFLDMLKNVLDGNMDSNTFEDTMREMFGIYAYISFTLDKVVSNAVRQLQYCVTERAALDCVELFATEQRRGCTGGFCRDAHKTFDREMSYQRKAESILNEENCFKVYIYKIDCRVTIELLDSEPEEVDKPAALKAQKFSKYVERLANPALGGGGNTGRSDSALGNDSVVDGSDIKTEADEDTAELIPRLEIT