lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MEKLFTTDLIIAFIAIVLHVVNYNATAQFEYKTRTFTKIIGKQTIYYYAVYLVISALIRDHFINAAIDKDQNSLVLFPQEVAKFFGNSCFIFGILLNIWTLKALGIKGMYNGDSFGHLMDAPVTTGPYVYFSDPQYVGTTIAAIGAAIRYQSMTGYLCSILVGIVFYISATFVETPHLNKIYSNRSYSKINFKNFNKKNL
The following text describes a protein:
Function:
Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenosine at position(s) 57 (m1A57) and 58 (m1A58) in the T-loop of some tRNAs. Methylates the first adenine of an AA sequence.
Domain:
Contains a large catalytic C-terminal domain that binds S-adenosyl-L-methionine and a smaller N-terminal domain that may play a role in tRNA recognition. Domains are connected by a linker region.
Sequence:
MIREGDKVVLVDPRGKRYLITVSKRDFHTDLGILKLEEIIGRNFGEAIKSHKGHEFKILRPRIVDYLDKMKRGPQIVHPKDAALIVAYAGISPGDFIVEAGVGSGALTLFLANIVGPEGRVVSYEIREDFAKLAWENIKWAGFDDRVTIKLKDIYEGIEEENVDHVILDLPQPERVVEHAAKALKPGGFFVAYTPCSNQVMRLHEKLREFKDYFMKPRTINVLVFDQEVKKECMRPRTTALVHTGYITFARRI
The following text describes a protein:
Function:
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position.
Miscellaneous:
MISCELLANEOUS: Can complement the E.coli plsC mutant.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Sequence:
MSTVQAIRTVLFYLLLSASAFVWGTLSFFIAPILPFRARYRFVVQNWCRFAIWLTRVVAGIRYEVRGLENIPEKPCVILSKHQSTWETFFLSGFFEPLSQVLKRELLYVPFFGWALALLKPIAIDRSQPKLALKQLAKQGDECLKKGAWVLIFPEGTRIPVGQMGKFSRGGTALAVNAGLPVLPIAHNAGQYWPKAGWAKYPGTIQVVIGPAMHAEGEGPRAIAELNQRAEAWVSETMAEISPIQQRVSHPEPSVVS
The following text describes a protein:
Function:
Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.
Subcellular Localization:
Nucleus.
Sequence:
MEGDGSDPEPPDAGEDSKSENGENAPIYCICRKPDINCFMIGCDNCNEWFHGDCIRITEKMAKAIREWYCRECREKDPKLEIRYRHKKSRERDGNERDSSEPRDEGGGRKRPVPDPDLQRRAGSGTGVGAMLARGSASPHKSSPQPLVATPSQHHQQQQQQIKRSARMCGECEACRRTEDCGHCDFCRDMKKFGGPNKIRQKCRLRQCQLRARLSPVTPSESLPRPRRPLPTQQQPQPSQKLGRIREDEGAVASSTVKEPPEATATPEPLSDEDLPLDPDLYQDFCAGAFDDHGLPWMSDTEESPFLDPALRKRAVKVKHVKRREKKSEKKKEERYKRHRQKQKHKDKWKHPERADAKDPASLPQCLGPGCVRPAQPSSKYCSDDCGMKLAANRIYEILPQRIQQWQQSPCIAEEHGKKLLERIRREQQSARTRLQEMERRFHELEAIILRAKQQAVREDEESNEGDSDDTDLQIFCVSCGHPINPRVALRHMERCYAKYESQTSFGSMYPTRIEGAKHTVSGSRCCAPSTHGTPKCQLTRYAGAPLYVMSLSSRVTSAACPSASAIAITAGRSCGVRKWTWSACVCGTSWTSCLSRSAMCAQP
The following text describes a protein:
Function:
Component of the allantoate transport system.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSADASTNSNASLDEKNLNITSEAEIKNEDVTAEPVLSTVLSPNGKIVYISDKVDEAMKLAEEAKEIEVTPEEDRKLRWKIDYCMFPLMCILYAVQFMDKISTSSAAVMGLRTDLKMHGDQYSWVTSAFYFGYLFMNLGPVQFIFQRTSHMSKMLAVFIVIWGMLLALHAAPTVKYPSFIVLRVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSIWFGMNGLGSILINAIAYGVYIHQDSYAIKGWRTLFVITGVITIFIGILIFLWIPDDPSKARFLSKREKLMVVQRIRSNQQGFGNHEIKKYQIIEALKDVRTWLYFLFTVSSNIPNGGISSFMSILLNSDFGYSSKETLLMGLPTGAVELVGCPLFGILAVYAANKKIPFWKYKLSWAIFAAVLALIASCMLGFATNSKKARLAGAYLWYISPVSFICVLSNISANSSGYSKKWTVSSINLVAYAAANLAGPQTFIAKQAPKYHGAKVAMVVCYAVMIVLLSILLIVNLRENKRRDKIAAERGFPEETENLEFSDLTDFENPNFRYTL
The following text describes a protein:
Function:
Mediates export of lysine.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MEELLSAVIIGIVLGWLCKDWLHFPNGSNLYVLITLIFFVGIQLRNNGISLKEVLLNKQGLMMGAIFTLSSLIGGVISAFFLSMPITQGLAFSSGFGWYSLSSVVLTNAWGPMQGSIAFFNDLSREILSLFLIPLFMQHYRSTAIEITGATALDCTLPIIQKSGGIEVTPIAISFGMVTNLLPPLLLVFFSSFPI
The following text describes a protein:
Function:
Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in proteins (By similarity). May methylate histone H3 and activate transcription via chromatin remodeling (By similarity). Involved in the development of the reproductive organs during worm maturation (Probable).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSAEYHNVELRMFDEAQFTCRTLGTGLTVGLRNSKVISVRRDNETVKEIHISSLSNIYRFSQKTVAVCTKKCVGDAVFTTYLLGFDSPGDVRGFLNSSDLLKPLCNENKKETRTSIFDRRTDSWSAVQYFQFYSYISQQQNMMQDYIRTSTYQKAILANASADFRGKVVLDVGAGSGILSFFAIQAGATRVYAVEASNMATHCNSLVQANKLAGRIVVISGKIEEITLPEPVDVIISEPMGYMLYNERMLESYVHARKFLAPHLRQPVKKKQNRRERERLDEDDQSPYVKQLSDSEHSDEVLTDELDCEDIDIEDQVHDGATKLSNKSLPCPGIMFPSVANLYIVPFSDEALFAEQYGKANFWYQQSFHGMDLTALRNAAVTEYFNQPIVDTFDIGICPALPCIHKVDFRTVSESELSSIDIPLNYQITTCSTIHGLAFWFDVGFLGSQRDVWLSTAPTEPLTHWYQVRCLLGTPLFVQEGQSLNGRVVMHANSRQSYDVQIELIVPGSETKIVNSLDLKNPHFRYNGYPPAPPPGSHVRSPTETYYANLCAQQQQQQQMEMQPQTMVNNGNPISLAAAAAAVVGGVGMPNNNSGQINYRNSPVYTMNQATGFLAATGSIPNIVQTIPLAVANDNLLQNQSHSMQLSPQPVNQSSLEFGRFITSNNSQIASSMLRSVNIPSATPVIEPLTNVSGSGIPTNESVYYNPVISSNFGDSCFTMNNVVNPSKNWNSGIHQE
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Miscellaneous:
MISCELLANEOUS: Present with 35500 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MTIAPITGTIKRRVIMDIVLGFSLGGVMASYWWWGFHMDKINKREKFYAELAERKKQEN
The following text describes a protein:
Function:
This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity).
Sequence:
MTDTPILGTVKEPQRDYRTLDRQKLTPMFQHYTEVKEQYQGALLLYRVGDFFECFFQDAVIIARELELILTSKEGGKEIGRVAMTGVPHHALDRYARQLVEKGYAVAICDQVEDAAEAQAEKRMVERQVTKLLTPGTLTDDSMLPAKRNNFLAAIAMVEDKWGLAHADISTGEFFTCQSSNLDDLAVELLRLQPSEVLIPTSAPDIRNILRPGEPSEHIPKQLPTSFCYSLRSQAPFSLVEAKQRLLTTFRVKSLEGMGCEGLPLAIRAAGGLLEYIEDTQKAHVVPIQPLKTYGLTDFLVLDHQTRRNLEINQTVRDGSFHGSLLWALDRTSTTMGSRALRRWLLQPLLDLKGIQARQDTIQELYHHPALRQDLRQLLRQIYDLERLTGRIGANTASARDVYGLASSLVRLTDLAELAQEGHSPYLKALQTVPPELEELGKYVLAHIVENPPLHIREGNLIRSGVNPTLDEMRQSLEDDNQWLANLEVTEREKTGIANLKVGYNKAFGYYLSLPRSKSEQAPDNYIRKQTLVNEERYITPELKERETRILTAQADLNQLEYEIFTEVRATVAEKAQPIRDVAKAVAAIDVLAGLAEVAVYQGYCRPIMQMEPGLIDIEAGRHPVVEQSLGAGFFVANDTQLGHDHWHPDLVILTGPNASGKSCYLRQVGLIQLMAQTGSFIPAKTATLSICDRIFTRVGAVDDLATGQSTFMVEMNETANILNHATAKSLVLLDEIGRGTATFDGLAIAWSVAEYLAGEIQARTIFATHYHELNELASLLENVANFQVTVKELPEEIIFLHQVTPGGADKSYGIEAGRLAGLPSSVITRARQVMAQIEKHSKIAVGLRKGNRGKVMASQAAAEAAEDQAKQLDIFGF
The following text describes a protein:
Function:
The glycine cleavage system catalyzes the degradation of glycine.
Sequence:
MSQDKKTPLYETHRTLGAKMIPFGGWDMPVQYSGIIAEHNATREAAGLFDVSHMGEIFITGNPKSILLFLESITCNSVASLSDFQVQYNAILNQNGGLVDDVTIYKFSSEKYMICSNASNYEAVTEHLLEHLPISGVKVDNQSLQWHQIALQGPKANEIFSKFLKRDLDSIQYYRFMLLPYQGEEIIVSRTGYTGEDGFEIYSSIPIGLKLWNELLEFGKPYGLLPCGLGARDTLRIEAKYPLYGHELNDQWTPIESGIGWIVKEKENPYFSSEKILFQKKNGVPSKIVSFALTEAGVPRENFRVLDSQGNEIGKTTSGTFSPSLKKGIGLALIQSEKIKDGEPIQIEIREQPKQAIITMKPFIPGSIRKN
The following text describes a protein:
Function:
This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis. ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically. It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein.
Sequence:
MAPGEKIKAKIKKNLPVTGPQAPNIKELMQWYCLNTNTHGCRRIVVSRGRLRRLLWILFTLTAVALIFWQCALLISSFYTVSVSIKVHFQKLDFPAVTICNINPYKYSAVRHLLADLEQETRAALKTLYGFSEITSRKRREAQSWSSVRKGTDPKFLNLAPLMAFEKGDTGKARDFFTGRKRKVNARIIHKASDVMHIHNSKEVVGFQLCSNDTSDCAVYTFSSGVNAIQEWYKLHYMNIMAQVSQEKKINMSYSADELLVTCFFDGVSCDARNFTLFHHPMYGNCYTFNNRQNETILSTSMGGSEFGLQVILYINEEEYNPFLVSSTGAKVIIHRQDEYPFVEDVGTEIETAMATSIGMHLTESFKLSDPYSQCTEDWSDVQITNIYNATYSLQICLHSCFQAKMVENCGCAQYSQPLPRGADYCNYQQHPNWMYCYYQLHQAFVREELGCQSVCKEACSFKEWTLTTSLAQWPSEVSEKWLLSILTWDQSQQIKKKLNKTDLAKLLIFYKDLNQRSIMENPANSIEQLLSNIGGQLGLWMSCSVVCVIEIIEVFFIDSLSIIARHQWHKAKGWWARRRAPACPEAPRAPQGRDNPSLDIDDDLPTFTSALSLPPAPGSQVPGTPPPRYNTLRLERAFSSQLTDTQTTFPH
The following text describes a protein:
Function:
Involved in the regulation of thiamine metabolism, phosphate metabolism, mating and cell growth.
Subcellular Localization:
Cytoplasm.
Sequence:
MAMSSITSAKQLNAEELLDECDSFNGEFVPGTIPFRANGAAIGYVTPLVLEILIKADNFKFNWVYVPGEYIEINASTFEKRTDILAKVLEHWRHNNTFGIADQWRNELYTVYGKSKKPVLAVERGGFWLFGFLSTGVHCTMYIPATKEHPLRIWVPRRSPTKQTWPNYLDNSVAGGIAHGDSVIGTMIKEFSEEANLDVSSMNLIPCGTVSYIKMEKRHWIQPELQYVFDLPVDDLVIPRINDGEVAGFSLLPLNQVLHELELKSFKPNCALVLLDFLIRHGIITPQHPQYLQTLERIHRPLPVPVGKYERGDSFEDTSKKAETCVPAKPQKATHQLAPCKAWLRDYDTDQKFAVLLLNQPIDIPDDRFRTLWKRASIRVCADGGANQLRNYDSSLKPDYVVGDFDSLTDETKAYYKEMGVNIVFDPCQNTTDFMKCHKIIKEHGIDTIFVLCGMGGRVDHAIGNLNHLFWAASISEKNEVFLLTELNVSTLLQPGINHVDCHDNIGLHCGLLPVGQSVYVKKTSGLEWNIEDRICQFGGLVSSCNVVTKATVTIEVNNFIVWTMETRL
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane.
Sequence:
MGALSFGGSRSRDKSPSTDPLAPLQVVAARVAQDVAAFAIKVDVWHTEGMKSARAKYGATVNLVGEFKSIAETRVKELKRAHAADNKVELGRSIRKRIQDMAEAPDANTQGSLSQSLQMPAPTSDSHGTQGSKQLDELRQWQAELATWELVQIIISQRFPEPETDPAAERQKRLAQVGGNKRYSPNSEIWDRFMLEDDRAKEKALVLRWLEQTARNDRSSIETITTELETQSGRGAHTWTSGWLDSKSRIKQAKRLEGADQPLRPDAVDIKTADRTQGLVTQLDPDGPARQKRVLEKSDEYYERALWMVCYEMLRRGLPWNEISEWAQERNEAWRGVSVGAAYEAHPKGGPNVAGPTVGYLFRRMCFYAARGARVPHEGAVYGLLSGDLKQVQTACRTWDDHLHAHYNALLLSRFDRYLISNYPNKVNASLVQKFVFQDAASHIGDWDRASRTVITLLKQEKATETEASSPFKLIQGALIAGTLDELLLKVGTSLADMLVNDERPENLMLHPDSNHTDPGPKPLDQTRTYTAEPCFKALACNPQAFQTLVHIFLLFKHGLNTLDSDEMGTWVAMDNVITAYIECLRQRGQIMSIPIYAAQLAPERAAHCLARIIPDVRNTQERIKMVGLFRQYKTDVIEVVAQSFLFAFKNSGFTHFNEKGDTIITSPIKRFKIIERTGSQDFGLWPGYRIQAEFTGCQIEPKEDAIIEVLQWYQYINNDYKQTFDHLRNALTILLLNGRLGAAEKVVSDLSVESLSLSRTEALCGYPFDINQPGAEERDEASLHEHRSTLTDDDLRNALRYDAMPNAEKHAAIVQRLRENSQPYYDLQLIVRILCLFREWRQEEEDLIKLRTDQSRQPSEAAAAKKKADMSHTKEVLESIEQVFTALVSAITTSLRDHPEAENPDTWNLKFAYIPEIVLAYLSVLQTAAFFLQRDSAVSSAVRAMEIANLVADEENEWLQEVFLKTGRMSELVDALAMVSKAMLRLNEHEPKKSTSKKRGSKGETLRIWDLNAKSRV
The following text describes a protein:
Function:
Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages. Probably acts as an arginine hydroxylase (By similarity). May also have methyltransferase activity.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRTTFRKGFNLKCFSKDWNQTRQYSNYTKMTIFDTNVKTIQKNNTVTNVDDPKHYDYLMNEVADRLADRILDIKDIKCGNVLDFGSRNGALFKYIQEKGAKIDKYYMVESSKELLYRDDNNVSQENEDDNNNNKVKPTKILVNSLEDKIEGIEDQSLDLIISNLSLHWVNDLPGVFGGLKRLLKPNGVFLASLFGEDTLMELKDSLYLAEIEREGGFSPHVSPFTKISDIGNILSKNRYTLPTVDTEKITINYDNMFVLMRDLQNMGENNAILKRRNYTSKDTFLAASAIYKHLYGNEDNNSIPATFQIIYLIGWAPHESQQKPLQRGSAKKHFSEISGTSSFGYKFDNDSSIPSILTNENNSVTLSQQQQQQGIEPQQSNDDSINEPFPKTDDFVIKRLDYHGNFHFEKQQQQQQQQDQNKESSDEINKNKDDK
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Binds to the flavoprotein subunit sdh1 in its FAD-bound form, blocking the generation of excess reactive oxygen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit sdh2 into the SDH catalytic dimer.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MFNRNLRAVILKNYNKALTRCLHDAGNLKRPTPPRLPKEQQEEWDRLQKESSKRPVDVMRREKHKDFEGDVNPKTGEIGGPKSEPTVHGDYSYEGRVTDF
The following text describes a protein:
Function:
Endoglycosidase which is a cell surface and extracellular matrix-degrading enzyme. Cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans.
Subcellular Localization:
Lysosome membrane; Peripheral membrane protein. Secreted.
Sequence:
MKGGQFVLIFLVAFIPIIYGKNVTMGKIVVDGTIRKAQTDENYICMTIDYWPFNECSTLPCLWDGNASALILNLSLPTLTKAVQAFKTLRIRVGGSLQDKLIYDVGSFKGNCPQFARNSSALFQISDGCLSMERWDDLNQFFNKTGAIVTFGLNALLGRHHTTGLQWEGDWNYTNAEAFIQYTIEKNYRINSWEFGNEMVGHNSIGANVTSAQYEKDLIKLREIIDRLYNNSQQKASIAAPSAFFYAPWYKDFVNGTGPGIVDILTHHIYNMGAGDDPKVINNFVDPNYLSKESKDFQQLKNIVENDAPWSVAWVGEAGGTFHGGSPYISNTFVDGFWYIDQLAMAALYNTKVYCRQTLVGGFYGILLPHTLAPSPDYYGALLFHRLMGSGVLKVDNNVSSYLRTYAHCSKERSGVTMLFINLSNETEFTVDIENNMMSTSLADKASQREEYHLIPNNGLVRSSTVLLNGNLLETTEDGDLPDLTPIYRDSNSSITIATWSIVFVVIPHFEASACK
The following text describes a protein:
Function:
Rapidly hydrolyzes choline released into the synapse.
Sequence:
MVWIFGGGFVGGSSTLDVYDPKILVSEENIIYVALQYRLGSLGFLNLDQPGAPGNMGMLDQVMALKWIHSNIAFFGGNPNNITLFGQSAGAASASMHLLSPLSRNLFSQAIMQSGSATAPWAVGDKEQTIAGGFKLAMAVGCPYSRTNLSITLDCLKTINASTLINSEEFPLVTLDFSFVPIIDGVFLTEPPQRRRPTGNFKKCNIIMGSNKEEGYFFMFYSLSQLFPRQENVTINRQQFLQSVQNMNPFSSSIGRQAIIFEYTDWSDPDDPNRNRDALDKMVGDSQLTCNVNEFAQYYAETKGSSNNVYMYYYTSIALQPICGRPGQASSTLTRLISSSENHSIQPRAIYLMRSHSARELCAIGLTLLETGIDFFAL
The following text describes a protein:
Function:
Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
Sequence:
MRKRLLSWFSDNARDLPWRRDHSPYRVWISEIMCQQTQVATVLPYFERFLSTYPTIRDLADADESQLMRMWEGLGYYRRARSLHAAAKKMVEEHNGEFPESFDDVLALPGIGRYTAGAIQSISRNKAFPILEGNTQRVFSRWIGLTVPPTEKVAQARLWELSDKMLPPRKADDRSNGPAGFNQAAMELGALICSPRSPKCDECPVATMCHANQMGLQDEIPGKISKVQYESRTELAVVISRDDRYLVRTIPEGVRFAGMIDFPRAGPPEAADVVGMESWLADQLGGDVRIGMCLKTIKHAVTRYRMTLHVHIGEWIADGDRVAESGPIPDSWQWATVDELADMPMSVTGRKIVRLLDRPQRSLFSEL
The following text describes a protein:
Function:
Transcription factor that regulates the development of root hairs. Does not seem to be involved in the regulation of sperm cell development.
Subcellular Localization:
Nucleus.
Sequence:
MENGNGEGKGEFINQNNDFFLDSMSMLSSLPPCWDPSLPPPPPPPQSLFHALAVDAPFPDQFHHPQESGGPTMGSQEGLQPQGTVSTTSAPVVRQKPRVRARRGQATDPHSIAERLRRERIAERMKSLQELVPNTNKTDKASMLDEIIEYVRFLQLQVKVLSMSRLGGAGSVGPRLNGLSAEAGGRLNALTAPCNGLNGNGNATGSSNESLRSTEQRVAKLMEEDMGSAMQYLQGKGLCLMPISLATAISSSTTHSRGSLFNPISSAVAAEDSNVTATAVAAPEASSTMDDVSASKA
The following text describes a protein:
Function:
Co-chaperone that stimulates hspD/HSP90 ATPase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MAKVGEGDPRWIVENREDGHNVNGWHWSEKDCLPWSKNTIGGLFDKKVIQETDEYTFKISSTPVVSGECTANNRKGKTIFLYELDVKMNWEVVFKPKKVLPPPPTTKSKGAADDIDEEDDDGKPAEPIITQKKTISGEFTVPYISDENGDEAPTVRYTINTTADNDETKQSINMVQSLLKSHGVPFVQSQCQEFIKLLKKEFVSKKQVEQSQQQQTANTTTNTTTTTNTVPKVTSSTVIFNSTPTKKPTTKTLKLKEEFQCSPMDAYDVFVNINKLRAFTQSDCTFENEEGGKFSLYGGSIQGVNKTLSPGSKIVQTWRLDNWSKGVESQVTITFSVDGKPLTNVEIVQTGIPIDEFEKTEEGWKRNILDRIKHTFSYSSKIF
The following text describes a protein:
Function:
Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
Miscellaneous:
MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein; [Isoform 3]: Secreted; [Isoform 4]: Secreted; [Isoform 6]: Secreted.
Domain:
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding; The box 1 motif is required for JAK interaction and/or activation.
Sequence:
MLLLVTSLLLCELPHPAFLLIPEKSDLRTVAPASSLNVRFDSRTMNLSWDCQENTTFSKCFLTDKKNRVVEPRLSNNECSCTFREICLHEGVTFEVHVNTSQRGFQQKLLYPNSGREGTAAQNFSCFIYNADLMNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHLDNLSGLTSRNYFLVNGTSREIGIQFFDSLLDTKKIERFNPPSNVTVRCNTTHCLVRWKQPRTYQKLSYLDFQYQLDVHRKNTQPGTENLLINVSGDLENRYNFPSSEPRAKHSVKIRAADVRILNWSSWSEAIEFGSDDGNLGSVYIYVLLIVGTLVCGIVLGFLFKRFLRIQRLFPPVPQIKDKLNDNHEVEDEIIWEEFTPEEGKGYREEVLTVKEIT
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVAPAPAPASSLEVDGTQLLLGYLGVGTALLLIGSPIPTFWRIVKTKQVGEEEPYSYMSVLFNAAACVIYGLPVFADKTNKPVMLANGVGVILEFVYVILFIMYVAAERRRNPMIILIGVVVAIMALLGLLLGTVFFGHVWTRTYMGWIAMLSGVAMYLAPIFKTVGAWKNSDRARLSVIQSMAALANGTMWTAYALVGRHIIWFTLVPSVVGIGSAGFRVIVWLILYCREAQEGEGARAQRRGGSNLQMSLRQPQGQRQGQGGGDAGGEGRHQLPPGPVVRPGLSSSCPLSSSSSSKEKTARASTSSTWP
The following text describes a protein:
Function:
Probably acts as a transcriptional regulator. Required for the specification of the tarsal segment. Also involved in antenna development.
Miscellaneous:
MISCELLANEOUS: 'Bric-a-brac' means 'jumble' in French (referring to the mutant ovary phenotype).
Subcellular Localization:
Nucleus.
Sequence:
MDMTKQIVDFEIKSELIGEIDQFEASDYTMAPPEEPKMVEESPQLGHLEDQNRKYSPEREVEPTLQDPSEVVDQMQKDTESVGEVKSPEKDVETELVKSKASPMNDQALTPPPRPLTSSEVVGLRDPEHTELRMCLEAKKSRSLPVSPQPQPNLKLAGSALFEFGQRSSPVETKIKTNPETKPPRRKIVPPSGEGQQFCLRWNNYQSNLTNVFDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPCQHPIIIMRDVSWSDLKALVEFMYKGEINVCQDQINPLLKVAETLKIRGLAEVSAGRGEGGASALPMSAFDDEDEEEELASATAILQQDGDADPDEEMKAKRPRLLPEGVLDLNQRQRKRSRDGSYATPSPSLQGGESEISERGSSGTPGQSQSQPLAMTTSTIVRNPFASPNPQTLEGRNSAMNAVANQRKSPAPTATGHSNGNSGAAMHSPPGGVAVQSALPPHMAAIVPPPPSAMHHHAQQLAAQHQLAHSHAMASALAAAAAGAGAAGAGGAGSGSGSGASAPTGGTGVAGSGAGAAVGSHHDDMEIKPEIAEMIREEERAKMIESGGHGGWMGAAAAATGAASVAADSYQYQLQSMWQKCWNTNQQNLVQQLRFRERGPLKSWRPEAMAEAIFSVLKEGLSLSQAARKFDIPYPTFVLYANRVHNMLGPSLDGGADPRPKARGRPQRILLGMWPEELIRSVIKAVVFRDYREIKEDMSAHQYANGQGHGTYIGGGTTTNGYHSAAAAKLAAQNAALAPPDAGSPLSSMTETLRRQILSQQQQHQQHHQQQAHHQQQPSHHQQQSPHAQSMNMYKSPAYLQRSEIEDQVSAAAAVAAAAAKHQQQQGERRGSENLPDLSALGLMGLPGLNVMPSRGSGGGSGGAAPNSAASYARELSRERERDRERERERELSRQYGSQSRGSSSGSGSAKSLTASQRPGAASPYSAAHYAKHQASAYNKRFLESLPAGIDLEAFANGLLQKSVNKSPRFEDFFPGPGQDMSELFANPDASAAAAAAAYAPPGAIRESPLMKIKLEQQHATELPHED
The following text describes a protein:
Function:
Peptidoglycan polymerase that is essential for cell division.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPGSPQSRTGRPPVQRTVKRPAAPGPPHDNGVLRLYHRLRRAWDRPLTAYYLIFGGSALITVLGLVMVYSASQITALQLSLPGSYFFRKQALAALIGAGLLVAAMKMPVKLHRALAYPILAGAVFLMILVQVPGIGVAVNGNQNWISLGGSFQIQPSEFGKLALVLWGADLLARKHDKKLLTQWKHMLVPLVPAAFMLLGLIMIGGDMGTAIILTAILFGLLWLAGAPTRLFAGVLSIALLLGFILIKTSANRMARLNCLGATDPGPGDSCWQAVHGIYALASGGLFGSGLGASVEKWGQLPEAHTDFIFAVTGEELGLAGTLSVLALFAALGYAGIRVAGRTEDPFVRYAAGGVTTWITAQAVINIGAVLGLLPIAGVPLPLFSYGGSALLPTMFAIGLLIAFARDEPGARAALALRQPRFGRKRGAGGPAAKRSPGSWNTMRRRASAARSSGER
The following text describes a protein:
Function:
Essential cell division protein.
Subcellular Localization:
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Sequence:
MDGAGSLTRSFFRSLRPQADLKAAAIGAVVLLREWVQDKRRERLHAARAAAKDKIKAKAVVEREPPPRVVALVERYLPRRVGISMTVLLLIGSCGFGIVKGGHLQDFVTAISDARNAMANSAGFRITSVVINGRKQLTQDEILAIGGVSGRSSLLFLDADAVRDKLKANPWIADATVLKLYPGQLMIELTERKAFALWQEAGRLSVIADDGAVLEPYVSRRFLSLPLVVGKGADTQARDFLALLARYPQVNSITKAAIFVGERRWNLRLKDGLDIRLPEQDVGNALAMLSRLDKEDKLFSRDIVAVDMRLPDRLVVQLSEDAAKAREEQFKDKKKKKAGDAA
The following text describes a protein:
Function:
GTPase that plays an essential role in the late steps of ribosome biogenesis.
Sequence:
MRIAILGRPNVGKSSLFNRLCKRSLAIVNSQEGTTRDRLYGEIRAWDSIIHVIDTGGVDQESTDRFQKQIHQQALAAAEEASVLLLVVDIRCGITKQDEELAKRLLPLKKPLILVMNKADSQQDLQRIHEFYGLGISDMIATSASHDKHIDLLLERIRQIAQIPVPSVEEQDAVQEDELPSEEAAISLHAFADETLFENESLSQEEASFLEELVAQTATPAPVDRPLKVALIGHPNVGKSSIINALLKEERCITDNSPGTTRDNIDVAYTHNNKEYVFIDTAGLRKTKSIKNSVEWMSSSRTEKAISRTDICLLVIDATQQLSYQDKRILSMIARYKKPHVILVNKWDLMFGVRMEHYVQDLRKMDPYIGQARILCISAKQRRNLLQIFSAIDDIYTIATTKLSTSLVNKVLASAMQRHHPQVINGKRLRIYYAIHKTTTPFTFLLFINSNSLLTKPYELYLKNTLKAAFNLYRVPFDLEYKAKPARKSN
The following text describes a protein:
Function:
Role in flagellar biosynthesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Bacterial flagellum basal body.
Sequence:
MLSFDTHQLSVWVSQYFWPLVRVLALIGTAPLLSEKQINKKVKIGLGVLITFLIAPSLPPVNIPLFSSAALWVAIQQILIGVALGVTMQFAFAAVRLSGEVIGLQMGLSFATFFDPSGGPNMPVLSRLLNILVTLLFLSFDGHLWLISLLADSFHTLPIQFAPLNGNGFLTLAQSGSMIFMNGLMLALPLITLLLTLNMALGMLNRMTPQLSVFVIGFPLTLTVGIISLGLIMPLLAPFTEHLFSEFFDRLAEVLSGMAN
The following text describes a protein:
Function:
Binds to single-stranded DNA and also promotes the renaturation of complementary single-stranded DNA. Function in recombination. Has a function similar to that of lambda RedB.
Sequence:
MTKQPPIAKADLQKTQGNRAPAAVKNSDVISFINQPSMKEQLAAALPRHMTAERMIRIATTEIRKVPALGNCDTMSFVSAIVQCSQLGLEPGSALGHAYLLPFGNKNEKSGKKNVQLIIGYRGMIDLARRSGQIASLSARVVREGDEFSFEFGLDEKLIHRPGENEDAPVTHVYAVARLKDGGTQFEVMTRKQIELVRSLSKAGNNGPWVTHWEEMAKKTAIRRLFKYLPVSIEIQRAVSMDEKEPLTIDPADSSVLTGEYSVIDNSEE
The following text describes a protein:
Function:
Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions. Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity). Also recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia and mediates macrophage activation (By similarity). Through recognition of DAMPs released upon nonhomeostatic cell death, enables immune sensing of damaged self and promotes inflammatory cell infiltration into the damaged tissue (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Cell projection, phagocytic cup.
Sequence:
MNSSKSSETQCTERGCFSSQMFLWTVAGIPILFLSACFITRCVVTFRIFQTCDEKKFQLPENFTELSCYNYGSGSVKNCCPLNWEYFQSSCYFFSTDTISWALSLKNCSAMGAHLVVINSQEEQEFLSYKKPKMREFFIGLSDQVVEGQWQWVDGTPLTKSLSFWDVGEPNNIATLEDCATMRDSSNPRQNWNDVTCFLNYFRICEMVGINPLNKGKSL
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
MATESKVATEDAKVDLFEDDDEFEEFEIGEEWDEKEEGKGATQQWEDDWDDDDVNDDFSLQLRKELENNSEKK