lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MDRNCNYMNKIINSKNRRHYSMHPENAIFFDYFINLKKKAIAQGYNNLVISFKKIISSITKYPLPIKNSLDAYKLKGVGKRFSNYFEKALSQSKVDKKIQNLKEDFISSKSEFRINIHINKVINSADKFLKDFDKEIYNIRVLGELSDDNILNNIREIENDNLCNVNSKNLNQCTLVSSNKLNESYSNGKSLSLCTNNIEKVTSLNNNKKKKCIDMNDTEKSIITYLYKYGHLYNEHALSKEEIISGVLKYYERSIVVNYKTLRRLINREFIEKTESVENRICNNIKSSKIKTKLKVINKIRLTKKGKDFLDNEKDYILDCSLINTENIYQLNNTKEEESMLHTENVKNMISQYSFNTDNELKEEDNNMSSKKKIDSPSYMKKNLRCSDTEEKCFELSEKKENQERCLNVTYLSISKNNEIISHECLFKNENEMEKNDEEEKNDEKKKNDEMNNKQNRQENISINNIQTSDAVLVQKEEKEEFSECNQLFKNTKTLSSSSYTNYSISFGFNDDIKKKTDSSWNNKKGRIYKKYKPRIFTKTKEIIEEDKNKILKKKKKSINNEESIDSKSVSILSDNYEERKKTDGNVNGLNLSNSYDLIEKKIKNIKKRMNKNLKERLEKKKKNRNDSGVSSSEMFEGSSSKEENFFSSDRKKLSLEEEDKSLKLTNYIWDEDQVEEKKGEKTETKFLIKEYEKYYNEIDESKKMKSFVTDELIYKSTVLKNNSKNIIKEVEDSNMLLSNVQKDTNHLREEEFLSLRNENVNSINNNDDKEKGKKCKRKRSILNNIGNNKDAEGNKRKKKKRSKPETENKVEFDTSNINNLNKEDKDLNEMNESNQRCKITYGTYEIIMIIDNREVTGSSYEFNEKMKKVFNDKNIKYETRNLPLGDIIWICRRSVYNKNSSSNKKKQMKKMRRNKKMMDDEKKKKSEEINMDIKKGILERNNHSVSKENDYHQISDDDNDDNNDDNNDDNNDDNNDDHNDDHNDDHNNDHNDDHNNDDDNIDDDNNNKKKEKVLCPDKKIEPFIDDVEYEEFVLKWIIERKTLNDLSASIIDGRYDEQKYRMMRLRDIHHIIYLIENCNNTYRNYMNSSKISYETLNNAQHSTQLVSGFSILGSQHMNHTLFLLCEIHQEIIKHIKLYCHIKKEHPVIRHNEDLSMYLQKYSCSWDEWNNESKKSKNNIVKEVFGKQLRLINMCGPDATELILSLWPTPTKLSAALNKYTHDGILAEKMKRIYLKNHDMIGKKRIKSPIDVQLIAQLRQLYAPDSIERW
The following text describes a protein:
Function:
Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.
Sequence:
MLVEDLLKNNYLITPSAYYLLSDHYKKAFTLAELIKFAKNRGTFVVDSNLAREFLAEKGIISSGNGALDGSVLSGISVSESPVKPNGEAVLESESDESGAIESSLQEGVEDGVESIAEPSAASVEDVVVAGESSLASEGSSLEDEINTEPELSSSMDDGAEVVQSSEGDETSISTGNALGSVDYGGSDSESEALEEASSGGESFISTGTPEDEALLEESPEGEFPDENGFSDESLPVENGSENGYGDSEEYYENGDNGVKPKIVYGDYGVPIAYVADETPEEEKAYSTYSDLVIAPKEGFHYRAKEIPDEWELAFDVKNVKFEVPKVKNAQSKEGEVIIQAYSSYFKSRLKKMRRIFRENPEIGTIVDIAKLSYVREDDVTIIGLVNEKRETRKGYLFEIEDATGRIKVFIGSDKEGANEAYSTIMPDSVVAFRGTPGKGIFFANRVFLPDVPKFKRSKPPLEEKVYAILLSDIHVGSNKFCEEAFIKFLEWLNGEVNSRTEEELVSRIKYIIIGGDVVDGVGIYPGQYNELAIPDIFDQYEALANLLKQVPDHITMFIGPGNHDAARTALPQPGFYEEYAKPLYKLKNAVIISNPAVIRLHGRDFLVAHGRGIEDVVDFVPNRSHHRPAEAMVELLKLRHIAPTFGNKVPIAPDPEDTLVIESVPDLFQAGHVHVMQYKTYNGVFVINTGTWQAQTEFQKMVNIIPTPARVPIIDVETARLRAVVRFDQFCEGV
The following text describes a protein:
Function:
Cell surface proteoglycan.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Sequence:
MVCSSARGALLLCALLLQLFPLPGGQVPNCQEVRAVFHSLHPGSKWVPETPVSGADLQICQTKGPTCCSKKMEDRYQVAARSNMESGLQAVSSQLKRLIIQNAAIFQEAFDLVLRHGRNSTLAMLKSEFPGLGSGAQGSVVQLFRDMSLYTLGSDSTVDNMVTVFLGKLFPLTHHRLLGGNVASVKEECLRGAWKDSGAFGPYPKLIMTRLSRSLLATRVFLQALNLGIEVVNTTHHLRPSRDCSRALLRLWYCPHCQGVLGPPPCRGFCQAVMQSCLGGAAEVQPHWRRYIEGLGKLAGGMRGEQDMEAVVLRLPSMIKLALKHAVSTRSHLSTLVSGICGNAPQRAARSVEPPPPLHQPPAATAARGAQPSDSDETLAGLRREFMSSLKGFSTFYSGLGEALCSREPPSANHSLCWNGQEMTDRFSGPGLKRLHPSSEAKSNKPLEPIISQIIDKLKHINQLLQMVAVSEKRWRAQSRGGGADGWGVEDEEGFQSGDCDDEDECVGVSGLGPPLRRKRLRIFADLSDNLAMDDFAFQEQLLTPRLATGGVGGVSSPAASLQRSCLVSVHFVTVALLLISHH
The following text describes a protein:
Function:
Probably has thioredoxin reductase-like oxidoreductase activity.
Sequence:
MERLTGRNVALLVLCLCAGYALVFAEGEKEIPVTKFGQNIAPTMTFLYCYSCGYRKAFEDYVGLLGEKYPQIQVNGGNYDPPGLNYYLSKMIFALKIIIIVSVVSAVSPFTFLGLNTPSWWSHMQANKIYACMMIFFLGNMLEAQLISSGAFEITLNDVPVWSKLQTGRFPSPEVLFQIIDNHLQFTEKVQENPDFVK
The following text describes a protein:
Function:
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.
Subcellular Localization:
Nucleus.
Sequence:
MFELKMVKGSTLQGVLEAILDLVNVANVDCSSKGFSLQALDTEHVVFLSLFFPSEVFRSYRCDEDCSMGIAIADMVDLLRASNDGDIITIKAKTTDMDLQLVYVDAPSHRLKISEWHDMESEYQAIFCMPSAQFMLNCKSLSVIGDDAVVVIRVNEEVISFSTKGKRRCVNISHVLNKTDKHVTLTHARGPVSLALNLRYMKSCAKVSTLFDQVKIGLSTTLPLMVECKIAEKGYIRYFVATKNLTEEEEGKTETEEAEGEEGRQRKKAKKKMMKREMRCWADE
The following text describes a protein:
Function:
Catalyzes an aldol-like condensation reaction between phosphoenolpyruvate (PEP) and D-erythrose 4-phosphate (E4P) to generate 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAH7P) and inorganic phosphate.
Sequence:
MNWTVDIPIDQLPPLPPLSDELRQRLDSALAKPAVQQPSWDPDAAKAMRTVLESVPPVTVPSEIEKLKGLLADVAQGKAFLLQGGDCAETFVDNTEPHIRANIRTLLQMAVVLTYGASMPVVKVARIAGQYAKPRSSDVDALGLKSYRGDMINGFAPDAAAREHDPSRLVRAYANASAAMNLMRALTSSGLASLHLVHEWNREFVRTSPAGARYEALAGEIDRGLNFMSACGVADRNLQTAEIFASHEALVLDYERAMLRLSNPAETDGAAKLYDQSAHYLWIGERTRQLDGAHVAFAEVIANPIGVKLGPTTTPELAVEYVERLDPNNEPGRLTLVTRMGNNKVRDLLPPIIEKVQATGHQVIWQCDPMHGNTHESSTGYKTRHFDRIVDEVQGFFEVHHALGTHPGGIHVEITGENVTECLGGAQDISDSDLAGRYETACDPRLNTQQSLELAFLVAEMLRD
The following text describes a protein:
Function:
Required for ubiquinone (coenzyme Q) biosynthesis. Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex. May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates.
Subcellular Localization:
Cytoplasm.
Sequence:
MPGSLFNSLKPLAGQALQAALNRALALDPDTRDALLPLEGQRIALTLEAPALALQIRVHERRLLVGPVDASQEPDLAVRSSLAGLLGQLPFLANARRSGAPAGRLKVSGDAELARQLQQLAGRFDPDWQLPFVAVFGEILGVQIASAVRSALQQARRSATDLAQSAAEFVTEESRDVVPRAELEAFHDDVDELRDAVERLAARINRLSAAGGTP
The following text describes a protein:
Function:
Orphan receptor. Seems to act through a G(q/11)-mediated pathway.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEHTHAHLAANSSACGLGFVPVVYYSFLLCLGLPANILTVIILSQLVARRQKSSYNYLLALAAADILVLFFIVFVDFLLEDFILTMQMPLIPDKIIEVLEFSSIHTSIWITVPLTVDRYIAVCHPLKYHTVSYPARTRKVILSVYITCFLTSIPYYWWPNIWTEDYISTSMHHVLVWIHCFTVYLVPCSIFFILNSIIVYKLRRKSNFRLRGYSTGKTTAILFTITSIFATLWAPRIIMILYHLYGAPIQNPWLVHIMLDVANMLALLNTAINFFLYCFISKRFRTMAAATLKALFKCQKQPVQFYTNHNFSITSSPWISPANSHCIKMLVYQYDKHGKPIKVSP
The following text describes a protein:
Function:
Major facilitator transporter involved in ferrichrome (FC) and ferrioxamine B (FOB) uptake.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAMHDPHEKNGPDAVESRVQTDFPVERFGGNGSPGVRRIEVISSQFNLVHRIIFFFGVFLIAYVYGLDGTIRYTYQPLATAEYQSHSLLATVNVLRSVIAAAAQPTAAKIADVFGRVELILLSIVFYTVGTIVEASANHLYEFCAGAVLYQIGYTSVILLVEVLIADVTSTRSRLLFSYIPALPFLINTWISGNVTSAVLKVTSWQWGIGMFAIIYPVCTIPLLAVLFVGHLKARRANPQAYKFSLLDQGVGQFFIDLFWYLDVVGILLLIAILALILVPFTIAGGAVTQWKTAKVIAPLVIGVLCVPAFIVWERWCPHPMVPFKLLKDRAIWGALGIAVMLNTAWTLQGDYLYTVLIVSFDESVMSATRITSLYSFVSVITGTILGAIVIYVRRLKPFIVAGTLVFMAAFGILIRFRGGADGTNHAGIIGGQILLGFAGGLFPYPAQASVQVASKHKYLAVITGIYLATYNVGSALGNTISGAIWTQVLPGELENRLGNATLAAEVYANPFAFTQVNPVGTPDRDAVILAYKHAQRLLCITGICLTVPLIAFSLCIRNPRLTKEQTLKEAEEIDDK
The following text describes a protein:
Function:
Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB.
Subcellular Localization:
Nucleus.
Sequence:
MSTALYSLDSPACYRNWSMEPANFYETNKGGGGGGPGGLGSSCKPGRGPQSGSEEHGGSGGGGGGGGGAGGGGGGGGANLAELSAAAPAMYDDESAIDFSSYIDSMSSVPNLELCHDELFADLFNSNQKPDRGGGAGGGGASHASAGDYEYLPGHPAHPHPQAHKDFASAMASLLGAGTSASPPGALKQEPDWSDSDMSSSLLPSQIATCAQTIMNLSTAGQPTPPTSPEPSGCSSSSSCSSGRSPSAPAPQPPHLSKEKGGGSGGKKSLDRFSPEYRQRRERNNIAVRKSRDKAKKRNQEMQQKLVELSSENEKLHKKIEQLTRDLTSLRQFFKQLPSSSFLQAGTASSGIDCR
The following text describes a protein:
Function:
May be involved in intracellular signaling through interaction with PtdInsPs and calmodulin (CaM); may keep PtdInsPs attached to the plasma membrane until Ca(2+)-CaM reaches a competitive concentration subsequent to an increase triggered by a stimulus, thus leading to PtdInsPs release and subsequent activation of InsPs-dependent signaling cascade (Probable). Binds to microtubules and inhibits tubulin polymerization. Regulates directional cell growth and cortical microtubule organization by destabilizing microtubules (e.g. in cotyledon pavement cells).
Subcellular Localization:
Cell membrane; Lipid-anchor. Cytoplasm, cytoskeleton. Note=Localized along cortical microtubules as patches of dot-like structures.
Sequence:
MGYWKSKVVPRMKKLFEKSPAKKEVVEEEKPREVEVVEEVVVKTEEPAKEGETKPEEIIATGEKEIEIVEEKKEEAKPVEVPVLAAAEEKKPAVEEEKKTAPVEEKKPAVEEEKKPAVEEKKPVEEEKKEVVAAVPVAETPSTKAPETPVVETPAKAPETPAAAPQKA
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes. Required for transcriptional activation in response to lipopolysacchardie (LPS).
Subcellular Localization:
Nucleus.
Sequence:
MTILYKVEGKEFSKDSVFPHKKVLCSVSARNIVAFSALQSAIFPASHGGDAGDGSLPGAGLAVGASNSHVYVCDIVTPWEYYKVCSSKSLISVLQWSPNGEQLLLGYVGGRVEIWQPRNQSINLWVLQYYATVPSEDIIEAQFFQNGKGVIFNALKKDHTYYAEKFERVEQQRPTLSGFGGVASEGCVLLTSSGLLAAFSLPAIQKTSAAGADGPAHEVVELTPALHSIGISRSFIEHCSMTPSPSGALNIAFSCGWQQQLVQCFKVSLSLEGELGLEQHLAIKSESQTSIFLGPLDGRRISHLKWTRIANEDVIFIAYACPDGAGSQLEQWTLTRRHQSVHALLQGGGGANNKPNEFVQSESWEQVGKVQLNASLADISVTRLSVSTPDSCQVYAILQDNSVQVLEPNSMKQLNHTQFDRLSDASGAVKFVSGDLTPSSQILLIFDSHAQLYAMQAPLPKQGGSGLLLLEYCIVTGCDASDVLLLNLGNLEALVEKLTDNFTRQPSFVRHFYYANFLALKSNICRMQQQEFDNLIILHAISTTFKSLLRPSDLGFQDKGPADNLAIKLAESIPDVDTVMLNLDAKDFTVEPVMLQSLQQLIQWVTDLALNMLHRLPEEVMKTKLSGKRPSYDISRDIVAISSLRELLVMIRIWGLLNTQCLPVYTKTMDNIDVLVILFRLLTRLAQNPAEPDEMLLDECSLLSKQLLIPQPTKFNPTTLLSAQGFAAVKSGQLQFTSMEEPTCLQDMETEEVVFASSVKDGVSNLQLGARPSHIRRCARCGFVFVNNASKVAKTSALKAWFSKWLHCHCGGFWKQVH
The following text describes a protein:
Function:
Cysteine protease required for autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins lgg-1, to reveal a C-terminal glycine (Probable). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (Probable). Its cleavage activity is functionally redundant to atg-4.1, but it cleaves lgg-1 precursors less efficiently than atg-4.1 (Probable). In contrast to atg-4.1, plays a more significant role in the later phases of autophagy and in addition has a role in autophagosome maturation. Acts redundantly with atg-4.1 to promote the lgg-1 delipidation to release the protein from membranes, which facilitates multiple events during macroautophagy. Regulates the accumulation of autophagic structures in neurons and is specifically, required for the maturation and elimination of autophagosomes from the synaptic region of AIY interneurons.
Subcellular Localization:
Cytoplasm.
Sequence:
MNNIPDDFKKIASSSRLPRKYCSSESSLSDDDGHEIEHVLKHGAPEEALTPDTERMVVLGQDVVQSAPASLVPGGNLSWMSKIKSAGASMMGSIRPSSSSQDVHSTGEIEKHSKKKWKARLWSTWNNIKYSSTWMSDRSDEYGGENDVVFLGRRYSTSVDESGLRSGFENFCSDYYSRLWITYRTDFPALLDTDTTTDCGWGCMIRTTQMMVAQAIMVNRFGRDWRFTRRKRSHVAAHGDEDDFDREKIQEWMILKLFEDKPTAPLGIHKMVGIAAMGKGKKAVGSWYSPSEAVFIMKKALTESSSPLTGNTAMLLSIDGRVHIRDIEVETKNWMKKLILVIVVRLGAAELNPIYVPHLMRLFAMESCLGITGGRPDHSSWFVGYYGDQIIYLDPHVAHEYIPIDINPNTNVVDSDSKKAKKCPEKSYHCRLLSKMHFFDMDPSCALCFQFESREQFDNDMRQLNLSQFIDIDQGEEHGMKRVRDPMFSVVYGERRQPPSYEREVSETEQAQADKHGFEML
The following text describes a protein:
Function:
Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGDYKLAKEAFVSGNPGASIWSINAVSLVALATYALWIALSPYIRHGLLNNYLICVLPLLLGVTIFSTSPLVFASFLSIISLFFIAKSQKRFNFPRSPEKPKGQWLDESDSDEEPAEPASAAGSAAVSPAKLLPSQVAFASGSLLSTDPTISPMSPSSSSSSGHEDPLGIMGVNRRRSPLEGVSLDVPSHIDSKVRISPVPSLRLKKSRATKVQGVEEKGRLPFLTVYRAHMMLMTVICILAVDFEVFPRWQGKCEDFGTSLMDVGVGSFVFSLGLVSTKSLSPPPPPPTPTSPALNSHIIPLTPSPLSFILISLRKSVPVLVLGFIRLIMVKGSDYPEHVTEYGVHWNFFFTLALVPVLAVGVRPLTQWLRWSVLGVIISLLHQLCLTYYLQPIIFSFGRSGIFLANKEGFSSLPGYLSIFLIGLSIGDHVLRLSLPPRRERVVSETIEEHEQSHFERKKLDLIMELIGYSLGWWALLGGWIWAGGEVSRRLANAPYVFWVAAYNTTFLLGYLLLTHIIPSSISSQTSPSILVPRLLDAMNKNGLAVFLAANLLTGLVNVSMETMYAPAWLSMGVLMLYSLAVSCVGWVLKGRSIKI
The following text describes a protein:
Function:
Modulates cell-to-cell trafficking.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell junction, plasmodesma. Note=Co-localizes with the Grapevine fanleaf virus (GFLV) 2B-MP at the base of tubules within modified plasmodesmata.
Sequence:
MGLSISFLSIIMMMCLLFPDLNVVVKSATTEYTTLIYKGCARQQFSDPSGLYSQALSAMFGSLVSQSTKTRFYKTTTGTSTTTITGLFQCRGDLSNHDCYNCVSRLPVLSDKLCGKTIASRVQLSGCYLLYEVSGFSQISGMEMLFKTCGKNNIAGTGFEERRDTAFGVMQNGVVSGHGFYATTYESVYVLGQCEGDVGDTDCSGCVKNALEKAQVECGSSISGQIYLHKCFIAYSYYPNGVPRRSSSSSSSSSSSSSGSSNSDPSTSTGATGKTVAIIVGGAAGVGFLVICLLFAKNLMRKKHDDY
The following text describes a protein:
Function:
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSRAPFIVPALKKHTATVIMAHGLGDSGAGWVSLAHNWRRRGLFEEVTFIFPNAPMIPITVNFGMSMPGWYDITKLGRDLDFQEAVKNQDEAGILKSRDYFNSLIKEQMDQGIKPSRIVLGGFSQGGAMSLFSGITGQEKLGGVFGLSCYMLLSDRIKNYIPENFPNKKTPFFLAHGTEDDIVPHEFGKRSAEMAKELGLEDVTFNSYKYLSHSADPVEIEDLEKFLDRVIPAENGGSL
The following text describes a protein:
Function:
Involved in the degradation of terephthalate (TPA) via the protocatechuate (PCA) 4,5-cleavage pathway. Catalyzes the dehydrogenation of 1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate (DCD) to yield protocatechuate (PCA) (By similarity).
Sequence:
MTIVHRRLALAIGDPHGIGPEIALKALQQLSATERSLIKVYGPWSALEQAAQICQMESLLQDLIHEEAGSLAQPAQWGEITPQAGLSTVQSATAAIRACENGEVDAVIACPHHETAIHRAGIAFSGYPSLLANVLGMNEDEVFLMLVGAGLRIVHVTLHESVRSALERLSPQLVVDAVDAAVQTCTLLGVPKPQVAVFGINPHASEGQLFGLEDSQITAPAVETLRKCGLAVDGPMGADMVLAQRKHDLYVAMLHDQGHIPIKLLAPNGASALSIGGRVVLSSVGHGSAMDIAGRGVADSTALLRTIALLGAQPG
The following text describes a protein:
Function:
Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MNWHKGNIAEAVAASKAKGAVFVVFIEGQDEMTRKLERFVDDSQVRSRLETSDFVAIKVQGNSSAYGQFMSLYKIVPIPSLFFIGKTGTPLEIATGVTASVDELTEKIDKVLILAGKRTEPVAASSSSCAKTLDPNEVRSFAGADGSSSTGESQVVQTASENFRDPETTSVSNSPTGGVEEAKTNPPNSPVAASLASIPAAVSTSSLEGKSGSEAEAASPTALAAEKRAAASKVEGSATTSGAAARNFATNNLIPAVPLMTPAVPVPTQRPLEAQDNTESEERLAEVRNILEQKRKERVEEEKRMEKENELRRRRDGREAQSQQARAKEQELKNMQEQIKRERQEELAARERIRAQIAADRAEQAQRFNTPDISSTTNSVAATAASNVITTDASVSSVDETRLQIRLPGGIQRTKSFPAGEVLATVRVYVRNEMLAASDVRDFTLATSYPRREFQTEDEVKTLNELNLVPNAVVLVLTKEQVNRVVQSGGSLMTMLGTVIWALLTPAAKAFDYINKMGLRPLTQKLSVFMANFRWPGQRAGLEVYQGDAAARRNMDMFSLRPTPAPGYEYDGASTEQTGGSAERPTPQNQPGPGNTPPAHNTSQASASQSQQFQQRPGGYQPPKYGDSNIRRLQDTKKDEKDKDKATYNGNSTQQQ
The following text describes a protein:
Function:
Corepressor targeting diverse transcription regulators.
Subcellular Localization:
Nucleus.
Sequence:
MDKHKVKRQRLDRICDGIRPPILNGPMPVRPLVALLDGRDCTIEMPILKDVATVAFCDAQSTQEIHEKVLSEAVGALMYHTITLSREDLEKFKALRIIIKIGSGYDNIDIKSAAELGIAVCNIPSASVEETADSTLCHILNLYRRVTWLHQAMREGNRPASVEQIREVAGGAARIRGETLGIIGLGRIGQAVALRAKAFNFTVIFYDPYLADGVERSLGLQRMATLQELLMHSDCITLHCNLNEHNHHLINDFTIKQMRQGCFLVNTARGGLVDEKALAQALKDGRIRGAALDVHESEPFSFSQGPLKDAPNLICTPHTAWYSEHASIEAREEAAKEIRRAIAGPIPDSLRNCVNKDYLLAAVQWSGMEQAAVHPELNGASSYRFPPGVVGVTSAGHPSAIEGLVASSHPLIPSVSHTPSPGQTTKPDPDREIPTDQ
The following text describes a protein:
Function:
Plays a role in ciliogenesis.
Subcellular Localization:
Cytoplasm. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Sequence:
MAEKRQAYSVPEAMKQLIGPGGQKWANMDPEERMLAAATAFTRICAGQGEGDSRREAQAGQYDPYSKASVTPGKRPALPMHLHFPHTASRVTSSTVSETSQKCRKPVMKRKVLRRKPDGEVLVTDESVISECESGTESDLGLWDLRHRFMNLQFQEGTESPVVTSQKFNLPCEYQGISQEDQLICYLQREEMDPPVYEQDLIVASRPKSFILPRLDQLSRNRGKIDRVARYFEYKRDWDSMRFPGEDHRKELRWSVRGQMLSRTEPPSKPQHVYVPNNYLVPLRWGVRCDLANGVMPKKLPFPLSPS
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MKQTSNMNFKPLKIKPSLLKELKKEGLISIEEAEGNNVKILSADNLNSHNIHYGNKCKNVSKNNESKKKLSLKRKKDSTKRENQDDTTVGCISREDKKIKIEESLQNDRLEHFDINDNNFIEKRKRKRKRGKKKKKIINSNMQINTTDNNLKKEKDDEEEEEREQEREQEREQENEEKRGEKKSTENVNISNINSSSNQNSNKKKELFDIERIIKNEEELEKDNNIKYKIHCNNWNNGGKIFILHSVMKSLFDNAFFKPTEIQSKTLEKSINDKNDIVVISKTGTGKTLTFCLPILNNILINKLKEYKKKLKNIQKFRCLILVPTRELALQILKHFNYINKYINLFISTIIGGLNLNKQKRILMKKPEILICTPGRLKYFLHLENPIKYIYQMKNIRYLVCDEIDKMIEISFMKDISYIAKHIYKSVGDKKKKLIQTFLLSATLSLTVQLQNDNMTKLLNSIIIRKDKSFIINLSNEQNVYNDNSNILPELLTLYIVKLNERDIVCKLFYLIKSYFSYDINNNNHNDHHDNNKWEHPQDTHQNDEINKIIIFVNTIKSAKQLNAIFKHLFLHNNLESSIPKKYRSNLYIKNKVNIYSIHSKQKLKERLENINKFSQQNHKAILFCTDVLSRGIDLDKCDLIIQLNCPISDITFVHRSGRTARNFKKGKCICFITETEIYKWKTSLEKVGINIQDLQELDYLKSINEEDYAKINKAIECANKMIEFQDKLILKKKDSLLKKLAREAELDDEDEEEEERRRNKFYSDSENEYEHLNNQTIYKNILHLKKELYNTLYKQ
The following text describes a protein:
Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVRIKNRYIAVQIVPYTPTQSLRLNDHSLTKILLQNVEKYYGVYGLAVIEQGFRVKYINDRTKMAIIRCLHRGQRFVSSVLPLITLIGDVRAKFRTLYIGATIIQCNKFIVKHQKQFLDRTMGQITSAKERQDLFKRVMEFDMDR
The following text describes a protein:
Function:
Required for high affinity copper (probably reduced Cu I) transport into the cell.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEFLKRHEGHMHMSDSATSMVTSATSAVMDMASATMSMTMSSSTSSSSGMAMEGMDHGSSHMAMNMWLTASFKDYPVVFKDLRASTKAQAFGIFVLLFFVAFLARMLEFVRNYLEEIVWKNNNYAEVEQGISQHSANLQSPPVKSCCDDNAKEVVSDESIDKQNSPQHEETTKARGTGKSLSLASTISRDIIRLALCIIPDLFAYSLMLAAMTYTLTYFFAVVIGSGVGRFVAERLMEHYRIKRGPPRNCC
The following text describes a protein:
Function:
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MPQATNRRCSMHLLWEIPNRERRGGVKQTFPFMHVFMTSGGGDCPFFQFGTFQPVALAMLWDKTLWASSTSNCRVLSRKWSSLGRIRCGHLGGGRAPLLVYSPRMRCRETQPRHYRQEARPRLSDGEMSDLGEWFRSIPLITRYWFAGSIAVPLVGKLGLISPVYLFLWPDAFLNRFQIWRPITATFYFPVGPGTGFLYLVNLYFLYQYSSRLETGAFDGRPADYVFMLLFNWICIVITGLAMNMQLLMIPLIMSVLYVWAQLNRDMMVSFWFGTRFKACYLPWVILGFNYIIGGSIINELIGNLVGHLYFFLMFKYPMDLGGRNFLSTPQFLYHWLPSRRGGVSGFGVPPASMRRPADNRQGDGRHNWGQGFRLGD
The following text describes a protein:
Function:
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. Efficiently incises DNA duplexes containing 8-hydroxyguanine (8-OH-Gua), 8-hydroxyadenine (8-OH-Ade) and abasic (AP) sites placed opposite to a cytosine.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Nuclear and cytoplasmic in nurse cells and oocyte.
Sequence:
MLAHNLGFHKKRLFSNMKAVLQDRGVIGLSLEECDLERTLLGGQSFRWRSICDGNRTKYGGVVFNTYWVLQQEESFITYEAYGTSSPLATKDYSSLISDYLRVDFDLKVNQKDWLSKDDNFVKFLSKPVRLLSQEPFENIFSFLCSQNNNIKRISSMIEWFCATFGTKIGHFNGADAYTFPTINRFHDIPCEDLNAQLRAAKFGYRAKFIAQTLQEIQKKGGQNWFISLKSMPFEKAREELTLLPGIGYKVADCICLMSMGHLESVPVDIHIYRIAQNYYLPHLTGQKNVTKKIYEEVSKHFQKLHGKYAGWAQAILFSADLSQFQNTSTVACKKKSNKKPKK
The following text describes a protein:
Function:
Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MAVQYAPTKLRVPPGFQNLLEGLAREVLREQPDDIVQFAAQYFKNQLSIREETGKDDAKRGENLEKLMKGEEVDIDIDDPEVQKAATKIQASFRGHKTREQIKQDKQQKDEEEAAALKIQSSFRGHKAREEVKELMKSKSRESTREE
The following text describes a protein:
Function:
Acts as a component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon. SEC66 is required to attach or retain SEC72 in the SEC63 complex. It is essential for growth at elevated temperatures.
Miscellaneous:
MISCELLANEOUS: Present with 7820 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MSEFNETKFSNNGTFFETEEPIVETKSISVYTPLIYVFILVVSLVMFASSYRKKQAKKISEQPSIFDENDAHDLYFQIKEMSENEKIHEKVLKAALLNRGAESVRRSLKLKELAPQINLLYKNGSIGEDYWKRFETEVKLIELEFKDTLQEAERLQPGWVQLFVMVCKEICFNQALSRRYQSILKRKEVCIKEWELKINNDGRLVN
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Sequence:
MGYYRKGHFRKDGKWVSGHYVRTFGTKRRKGKTPQGCMILGNVDVVTDITKEEFQKNYFKKHKPLLIKNFASRWEAFDKWNFDFIREKAGEQDVPLHDNKPADASKSSDAPVTHMKMKDYIDTIRNKPSDLRIFFYIITDRLPELLKNFSYPDLGMKFFKRLPTLFFGGSDAHVLMHYDVDLGDFLHIHFEGKKRILLFDQKQSAYLYKVPLSVHTIYEVDYENPDYEKFPALKYAQGYEIFMEHGDALFIPGGFWHFNRYLEPGFSMSLRALPNKPAVFANMLYHVFIMRYTDKLMRKLFKAKWVNYKQKWAYEKSSEALAKHNGIVSTKRANEEGHIELAGFPHHSVDSYLPKLVRAGMRVAICDQLEDPKMVKGIVKRGVTELVTPGVTFNDQVLNSKKNNFLLSLHKEKEKFGIALVDISTGEFLVSEGNLEKLLHIVSTFDPSEIIYQRSVQIPEQLKNRSAFKLEDWAYQYNFAYEKLTNHFKTNSLKGFGIENQQSAITAAGAIFAYLVEDTHHNLLSHITKIQIIPQEDFLMMDNFTLRNLEIVYPSSAQGKSLLDIIDRTSTPMGGRLLRRRIILPLKSVNEINRRLSLIDFLNENDHLKYEISQLLKSISDLDRLMGKLAAEKISPKELGYLRQSLINIHKIKGLLHPHADVLAWLDPLYDQEELIKCLQNHLNDELPVNLAKGNVIKEGISEELDTLRGLQSKGRGFLDEMCQREIERTGISSLKIDFNNVFGYYIEVRNTHKDKVPADWLRKQTLVNAERYITEELKEYENQILGAEEKIGVLENQLYRKVCGDTIIYMDQIQQNSNIIAQLDVAVGLSELAVSESYTKPVLNESFAIDLKEARHPIIENALPLGEKYIPNDIYLDKDSQQIIMVTGPNMAGKSAILRQTAIVCLMAQIGSFVPAKYAEIGILDKIFTRVGYLHQHPTQAKTLFATHYHELNEMTVNFERVKNFHVSIQENKGNIIFLRKLIPGGSEHSFGIHVAKLAGMPAKVVNRANEILKTLEASRTQGSSSESIKRVTEENMQLSFFQLDDPVLENIREELTKIDINTLTPIEALMKLNAIKKMIGG
The following text describes a protein:
Function:
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MTSKLEQLKQFTTVVADTGDLDAITRLKPVDATTNPSLLLKAAAIPGYADLLKQVKADAKGDVDLACDKFAVAVGSGILKVIPGRISTEVDARLSFDEPALLNKARQLIALYEAAGVPKDRVLIKLASTWEGIRAAEKLEKEGIQTNLTLLFSFAQAQACADAGVFLISPFVGRIYDWYKKSTGKDYVGAEDPGVQSVTRIYNYYKANGYNTVVMGASFRNIGQIEQLAGCDRLTISPELLQQLSDDQGELPQVLKPGNAGEAKQPLNESQFRWAMNEDAMGTEKLAEGIRQFARDQEKLEKLMAEKA
The following text describes a protein:
Function:
Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex.
Sequence:
MADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRYLHQQWDKKARTPPRRETKSRWRRRARAQRHPVRWPGLTAPTCPRTPRSCASPIVCQLCPLPPTCVSAVRLLHPVHALQPHRTHVFIFLEFIYAVTRVKHWLKGHQAQPRGVGRCFLKHSGVPHLQQDLVGGQSPGRAGPPTHRAAFSLLPTHRPGTRVPPVPRPHSEPSPGQERAGPSGSFSFIIYHGLARAPRPPQ