lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates (By similarity).
Subcellular Localization:
Nucleus. Note=Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin (By similarity).
Sequence:
MDASSHDKPLSESKECVLNNSENDVFRLGTEPFVTPQKHVADATPNLCTPDTFKSPLDFTTVTVEQLGITPESFVKTSSGKSTSSLQKARRRSTVGVRGSPETNCLIRFIAQQRNLKKAVLSPLAREPHFEGSPRLYRNASVLRERMSAFRSAFHSIQETKMASSPSAAEADGESRISDLTRKEDLLEYQQSGFPVNSSSKRRRISSQDSPDNYLSGTKALADEACAGGASTDLAEKSPDIGSAQPGCMAAPLPELRETSQGLAVTDCVEGPVTPLSSGTATATRSPETPMCGSSSPSAKTTATRSPATPVCGSSTPSAKTFVLRSVLKKPGKLFSENGKESNLCDDGAHLISYPSNSCKEGRAGRENCKTPGCLNPRKRKRVTFGEDLSPEVFDESLPANTPLCKGGTPVRPRTVKTTSPLQSPVHEQFLQPNFDDKEENLENIEPPQGSFANLSLSKSSLSETPPGTNTCSSLNKDEEIICSIVRPTRTSQRRKQTLSSTGVCSSYTTQAEPRKEKMSRRKSREKKHTSAALPKKKQVLKSYRKKKKGKKDVEKCFYGPRDIASKKPLLSPIPELPEVSEATPLADCTQGTSSDDFNKCGQLEEVNSFEIPTQRKRRLPQKADSPELDPAHHQSQVSDKCCYLLPLTTASERGPNASTRDTGSEGNTRAESKCQSAKEPKPGTKMESGLVPRASVTQDHIVSKNPKPLGSPQSQDLFKAGQNLENPCEILIVSESMNLKCEKESECLAPQGSLQGSPVSTDSKRDLNCSEDVLIQNIKEPASHSENVGRKCAGNGSPGSGRERKWRRRTVCCGGQSSYLEQNGNPASSCSGENFVEISLESVQLIEELSNTIEQSFQRTSSKTKVRRSTRLQRDLENTGLVWLSPSPSTLQKPRRRMTICTLDSRGFECPSSKEETISSGQNPGPLPAVSGSESQGVGSSALPRKRRSLCGSTLTDANSATQPPDCKRKPSLKGESAQLP
The following text describes a protein:
Function:
Catalyzes the cleavage of the N-acyl linkage of the ceramides (Cers) to yield sphingosine (Sph) and free fatty acid at an optimal pH of 8-9. Also catalyzes the synthesis of Cers from Sph and fatty acid.
Miscellaneous:
MISCELLANEOUS: Alternate N-termini have been proposed by different authors. It either starts from Asp-25 or from Leu-27.
Subcellular Localization:
Secreted.
Sequence:
MSRSAFTALLLSCVLLALSMPARADDLPYRFGLGKADITGEAAEVGMMGYSSLEQKTAGIHMRQWARAFVIEEAASGRRLVYVNTDLGMIFQAVHLKVLARLKAKYPGVYDENNVMLAATHTHSGPGGFSHYAMYNLSVLGFQEKTFNAIVDGIVRSIERAQARLQPGRLFYGSGELRNANRNRSLLSHLKNPDIVGYEDGIDPQMSVLSFVDANGELAGAISWFPVHSTSMTNANHLISPDNKGYASYHWEHDVSRKSGFVAAFAQTNAGNLSPNLNLKPGSGPFDNEFDNTREIGLRQFAKAYEIAGQAQEEVLGELDSRFRFVDFTRLPIRPEFTDGQPRQLCTAAIGTSLAAGSTEDGPGPLGLEEGNNPFLSALGGLLTGVPPQELVQCQAEKTILADTGNKKPYPWTPTVLPIQMFRIGQLELLGAPAEFTVMAGVRIRRAVQAASEAAGIRHVVFNGYANAYASYVTTREEYAAQEYEGGSTLYGPWTQAAYQQLFVDMAVALRERLPVETSAIAPDLSCCQMNFQTGVVADDPYIGKSFGDVLQQPRESYRIGDKVTVAFVTGHPKNDLRTEKTFLEVVNIGKDGKQTPETVATDNDWDTQYRWERVGISASKATISWSIPPGTEPGHYYIRHYGNAKNFWTQKISEIGGSTRSFEVLGTTP
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MPEARSSGPDLTRWRKQQQPVRRTVSQVCPPPRRPLTVADIRSGMENERLGVVRDSMFQNPLIVKAAGPASVGTSYSVYDSSAVQKVIPSLAGHHIKGGPQAELGKPRERSYSLPGINFNYGLYIRGLDGGVPEAIGRWNVFKQQPTCPHELTRNYIAMNRGAVKAGLVTARENLLYRQLNDIRISDQDDRRMKKEPPPLPPNMTFGIRARPSTPFFDLLQHRYLQLWVQEQKATQKAIKLEKKQKVVLGKLYETRSSQLRKYKPPVKLDTLWHMPHFQKVGRHLDTFPTEADRQRALKAHREECAVRQGTLRMGNYTHP
The following text describes a protein:
Function:
Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. The enzymatic activity is enhanced by its interaction with gls-1. Required, together with gld-2, for early meiotic progression in male and female germ cells and for gld-1 protein accumulation in the hermaphrodite germline. In the germline, forms a complex with gls-1 which directly binds to gld-1 mRNA and prevents its degradation.
Miscellaneous:
MISCELLANEOUS: The gld-4 locus produces a single transcript that is SL-1 trans-spliced.
Subcellular Localization:
Cytoplasm. Cytoplasmic granule. Cytoplasm, perinuclear region. Note=Localizes to P granules. This association is less apparent during pachytene, becomes obvious in maturing oocytes and is most prominently visible in developing embryos.
Domain:
In contrast to other poly(A) RNA polymerases, lacks any RNA-binding domain.
Sequence:
MNEDSRLSSSQQPSTSTPRSSIPSTMNSDEPNTCRRLSQSQEQPSTSRTCKSETPEFGYSDSLPFAPWRRKRYGLNIQGLHEEIVDMYHWIKPNEIESRLRTKVFEKVRDSVLRRWKQKTIKISMFGSLRTNLFLPTSDIDVLVECDDWVGTPGDWLAETARGLEADNIAESVMVYGGAFVPIVKMVDRDTRLSIDISFNTVQGVRAASYIAKVKEEFPLIEPLVLLLKQFLHYRNLNQTFTGGLSSYGLVLLLVNFFQLYALNMRSRTIYDRGVNLGHLLLRFLELYSLEFNFEEMGISPGQCCYIPKSASGARYGHKQAQPGNLALEDPLLTANDVGRSTYNFSSIANAFGQAFQILLVAVTLRERKGKNHVAMRAYKGSLLHLIMPFTSKELTYRNWLMSGVLSMPGQEAPASYDLNQLHNTLVSPMVDLSRYAWLRKAPAKAEKRDSRPLTIVNPADDRQTLAQQLKKQILEQTEAKKSLEKMPACDDNKKEEELVATRETDVELEAEDTESEGHHNGENDLILTGPPLPTSTQSVNTSATVSTAASISEREDTDSPGLSSSMGNQSSEEDEDNGINNRNNSAVPVQFKKPFNEVVAQPARESKRTQTTSEDKMQDQFHFNGYSYPPPSRYAAGTAAPSHKHRNAHPQRQRPSIRNLSQGSDGSDEYNVESWNNNIRQGRRASSNSPSPSRQQTNTRNCGPTNNIPYDSFRSQNKNSTLDGSNNSSEEPITMYADVVKKKSSITTSTNTSTADVNVTNGNPIPANGIIPQSMAVVNVGRGSYRNALTTSPMTPPSAHTSMQKQHHLRKDNECGFDNNSATSSTDLSHHQPQLVPPVNRLQR
The following text describes a protein:
Function:
Catalyzes the attachment of tryptophan to tRNA(Trp).
Subcellular Localization:
Cytoplasm.
Sequence:
MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQHAITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGELERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAERFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKIKSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEVVVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR
The following text describes a protein:
Function:
Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids. Acts as an arginine sensor. Following activation by arginine binding, mediates transport of L-glutamine, leucine and tyrosine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation. However, the transport mechanism is not well defined and the role of sodium is not clear. Can disassemble the lysosomal folliculin complex (LFC), and thereby triggers GAP activity of FLCN:FNIP2 toward RRAGC. Acts as an cholesterol sensor that conveys increases in lysosomal cholesterol, leading to lysosomal recruitment and activation of mTORC1 via the Rag GTPases. Guanine exchange factor (GEF) that, upon arginine binding, stimulates GDP release from RRAGA and therefore activates the Rag GTPase heterodimer and the mTORC1 pathway in response to nutrient sufficiency.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein.
Domain:
The cytosolic N-terminus part of the protein mediates interaction with the Ragulator complex. The cytosolic N-terminus part of the protein destabilizes the LFC and thereby triggers GAP activity of FLCN:FNIP2 toward RRAGC. The cytosolic N-terminus part of the protein mediates interaction with the Rag GTPase heterodimer in a RRAGA GDP-loaded state dependent and upon arginine binding, leading to the GDP release and SLC38A9 dissociation from the activated Rag GTPase heterodimer (By similarity). The cytosolic N-terminus part of the protein exists at least in two distinct conformations; The first is when the N-terminus is bound snugly in the arginine binding site (in the absence of arginine, low luminal arginine state) and the second is where the N-terminus is released and the substrate-binding site is occupied by arginine (in the presence of arginine, high luminal arginine state) (By similarity); The CARC and CRAC motifs mediate binding to cholesterol.
Sequence:
MASVDGDSRHLLSEVEHEVSPGPMNIQFDSSDLRSKRPFYIEPTNIVNVNDVIQRVSDHAAAMNKRIHYYSRLTTPADKALIAPDHVVPAPEECYVYSPLGSAYKLKSYTEGYGKNTSLVTIFMIWNTMMGTSILSIPWGIKQAGFTTGMCVIVLMGLLTLYCCYRVVKSRSTISTSDTSTWEYPDVCKHYFGSFGQWSSLLFSLVSLIGAMIVYWVLMSNFLFNTGKFIFNFIHHINDTDTVLSTNNSNPVICPNAGSGGRPDNSSMIFYNNNTEVQLFEKWWDKSRTVPFYLIGLLLPLLNFKSPSFFSKFNILGTVSVLYLIFVVTLKAVRLGFHLEFHWFVPTEFFVPEIRAQFPQLMGVLTLAFFIHNCIITLLKNNKNQENNVRDLCIAYMLVTLTYLYIGILVFASFPSPPLPKDCIEQNFLDNFPSSDILSFIARIFLLFQMMTVYPLLGYLARVQLLGHIFGDIYPSIFHVLILNLVIVGAGVTMACFYPNIGGIIRYSGAACGLAFVFIYPSLIYIISLHQEERLTWPKLVFHVIIIILGLANLIAQFFM
The following text describes a protein:
Function:
Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.
Subcellular Localization:
Nucleus.
Sequence:
MVTNKWLPVRPRMSNSTYYDLAVADARFPFAGQNQFFCPVTEQAANHGYLPPPYLQEPLADATNRLNRAIQRKVLLAYIQYKNSAALSGNDAPAYFANYMHSTVCCQYVCRCTKFFSLASHYDGCHDAGCDICNTVRYNAVVDTFRPDFEHVEGGLLRVTGSGDSGQPTYGSSEAMQPMLKRLKLENPTAPSFPCHGMFYTMAPSNVQPSYAELPTSEQFSESPVSYNSEVTEVGVELLPKLLDCSTIANRMGMNMEVNTELPTSAKEMDKTLEMNIELLPKPIEDSTSPKEMGHNMEEWSIELISKLMEDSPSAKEISMEEENIKLIPKLIEDSTSAKEIDMNMKEENVQLMSKLIEDSSNAKEMGKDVAESFQGPPEVAIAGYKVVETDPVGSHREEDIGFINVTDNADNSRDHFNNLEINAFPSFSEELAAGCEEGETEARANSTQAELATKTELIAQESNDGKEIKLESLKQGGVSLIENFTAQQIKEHISSLRECIDQDLGKKEGANRRVNIDSKNSCQLCGADKLSLAPAPIYCSSCCARIRHSAKYYSIPEVDGIRYCLCSSCYKLSRSESITSSGILVSKAKLIKKINDEEAEEWWVQCDKCKSWQHQICALFNEKKNKEKKDCFLCPKCCLEEIENGEHKPPLVKTVFGAKDLPPTMLSDHLEQRLFRCLQKNREEKAKATGMSIDEVPEVEGLVVREVLSAQKLVKVNEKLLDILKDGNYPTEFPYKSKVILLFQKIDGADVCLFIMYTQEFGAECSQPNQRCVYISYLDSVKYFRPETETAAASGEPLRTVVYHEIMIGYLDYCKKRGFATCYIWACPPKKGEDYIFYFHPEIQKIPKSDKLRQWHKTMLLKAAKMGIVVGLTNLYDQFFSTGRYNSKVTAANLPYFDGDYWSGAAEDVIKHIEKASGQDLKKNKKIVSKRTLKAMGHTNPSGHATKDILLMQKLGQNILPMKEDFIIAHLQFVCVCCHRAILDGWRWFCRMCKSFQLCGRCHDAEQYIYKYSTHTSCNGEKHSLSRIMVDVPYDTNDNDASMDSGLFENRYRFLLFCQKNNYQFDTLRRAKHSSMMILYYLHNPTSLLAETTCCICDKDTPLDQCWQCKTCSDFFVCAACYHRHGCSLHVHKLSLHPSAVDSSAENRETLKKGLWKLLEVLLHASGCDHCSHPDCHLMKKLFFHSKVCTVRAAGGCKHCKKIWFILRKHSRSCKVSDCNVPRCRDLKQLAQSLALKPAAF
The following text describes a protein:
Function:
Involved in DNA repair and RecF pathway recombination.
Sequence:
MLQKTKGIVLHTLKYNDTSIIVDMYTELSGRTSFLVPVPRSRKAAVKSVLFQPLSFIEFEADFRPNATLYRVKEAKSFYPFTSIPYDPYKSSMALFLAEFLYRAVREEAENRPLFAYLQHSVIWLDECREGFANFHLVFLMRLSRFLGLYPNLEDYHTGDYFDLLNACFTSTRPQLHSSYINPEEAGRLRQLMRMNYETMHLFGMSRAERTRCLTIMNDYYRLHLPDFPALKSLDVLKELFD
The following text describes a protein:
Function:
Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
Subcellular Localization:
Secreted.
Sequence:
MKGISDSVQLHVMPVPAALSPSPEDRWYDKHMDMDSEDLTACGHPFLPDDKGRTKHSCQCSRPAVLLRAREAAQFLRPRQRRAYQVFEEAKQGHLERECVEEVCSKEEAREVFENDPETEYFYPRYQECLRKYGKPEDKNPNFAPCVQNLPDQCTPNPCDKKGTQLCQDLMGNFYCLCKAGWEGRLCNKDVNECAQKNGGCSQVCHNKPGSFQCACHSGFSLASDGRNCQDVDECADLNTCGDARCKNLPGSYSCLCDKGYTYSSQEKACQDVDECQQGRCEQTCVNSPGSYTCHCDGRGGLKLSPDMDTCEDILPCVPFAMAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLLAEFDFRTFDPEGVLFFAGGRSDSTWIVLGLRAGRLELQLRYNGVGRITSSGPIINHGMWQTISVEELERNLVIKVNKDAVMKIAVAGELFQLERGLYHLNLTVGGIPFKENDLVQPINPRLDGCMRSWNWLNGEDSAIQETVKANTKMQCFSVTERGSFFPGNAFAFYSLNYRVLLALVGDNHVVPLSVALVDYHSTKKLKKQLVVLAVEDIALALMEIKVCDSQEHIVTVSLRDGEATLEVDGTKGQSEVSATQLQERLDTLEKHLQGTVLTFVGGLPDVPVTSAPVTAYYRGCMTLEVNQKVLDLDEASYKHSDITSHSCPPVEHATL
The following text describes a protein:
Function:
Probably involved in the biogenesis of the COX complex.
Subcellular Localization:
Membrane. Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MKATLQLKRVMSLVISSCCGGVAGSSCSLARSLPVTTSLHRLSSPAWQQPLTAASPKLRLPPLSQSFSSSSHQRQDRSEEYTDAPEGYSKPGSSKSSKPWYRSPTTLVLGFIPIFTFGLGYWQIKRLKWKVSLIEELEDKLSRDPLRLPRNINIDVLPQFDFRLVSVKGSFDHSRTMFVGPRVRDGVMGYHVVVPFRRSEGGGMILINRGFVSEKQIVGTGEKRSLKDEAMPNGETEFVALLPRIYPANTFTPNNVPEKGSWFHVNPSQMAEWASSQAGVEALSLSPPEATPSTDSYTPSAGVAESVRNMLGSRETDRVLPVYLEQVFDGNVGEAAARVANGVPVGRAATIELRNQHAVYAATWFSLSACTAVMFGLLVRRGRS
The following text describes a protein:
Function:
May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MGRAMVVRLGLGLLLLALLLPTQIYCNQTSVAPFSGNQSISAAPNPTNATTRSGCSSLQSTAGLLALSLSLLHLYC
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds DNA of heat shock promoter elements (HSE).
Subcellular Localization:
Nucleus.
Domain:
The hydrophobic-rich region (HR-A/B) corresponds to the oligomerization domain.
Sequence:
MAFLVERCGGEMVVSMERSHGRSTTTAAAVTAAPAPFLSKTYQLVDDPSTDDVVSWGEDEATFVVWRPPEFARDLLPNYFKHNNFSSFVRQLNTYGFRKIVADRWEFANEFFRKGAKHLLSEIHRRKSSSCSQPQPPPPFPMHQHYPLSLFSPPTTPRSPPVGAAAAAAYHFQEEYCSSPADYAGGGGDLLAALSEDNRQLRRRNSLLLSELAHMRKLYNDIIYFLQNHVEPVAPPPLAAATSCRLVELGPSTTERRRCAASPSGDNDDDAAVRLFGVRLDDDHGKKRRVQLVQEDEGDEQGSEG
The following text describes a protein:
Function:
Methyltransferase involved in the biosynthesis of methylsalicylate in response to stresses. Utilizes salicylic acid (SA) more efficiently than benzoic acid (BA). Can also use anthranilic acid and m-hydroxybenzoic acid as substrate.
Sequence:
MDPRFINTIPSLRYDDDKCDDEYAFVKALCMSGGDGANSYSANSRLQKKVLSMAKPVLVRNTEEMMMNLDFPTYIKVAELGCSSGQNSFLAIFEIINTINVLCQHVNKNSPEIDCCLNDLPENDFNTTFKFVPFFNKELMITNKSSCFVYGAPGSFYSRLFSRNSLHLIHSSYALHWLSKVPEKLENNKGNLYITSSSPQSAYKAYLNQFQKDFTMFLRLRSEEIVSNGRMVLTFIGRNTLNDPLYRDCCHFWTLLSNSLRDLVFEGLVSESKLDAFNMPFYDPNVQELKEVIQKEGSFEINELESHGFDLGHYYEEDDFEAGRNEANGIRAVSEPMLIAHFGEEIIDTLFDKYAYHVTQHANCRNKTTVSLVVSLTKK
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTAVLASDVIVRTSTGEAVMFWVLSALALLGAVGVVLAVNAVYSAMFLAMTMIILAVFYMAQDALFLGVVQVVVYTGAVMMLFLFVLMLIGVDSAESLKETLRGQRVAAVLTGVGFGVLLISTIGQVATRGFAGLTVANANGNVEGLAALIFSRYLWAFELTSALLITAAVGAMVLAHRERFERRKTQRELSQERFRPGGHPTPLPNPGVYARHNAVDVAALLPDGSYSELSVPRMLRTRGADGLQTPSPGAVSGSLEGGAS
The following text describes a protein:
Function:
Histidine kinase involved in a two-component signaling pathway that regulates cell wall mannan biosynthesis. Part of the bifurcated SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to oxidative stress and probably also to changes in the osmolarity of the extracellular environment. Plays a role in the regulation of alternative oxidase (AOX) gene family expression. Required for hyphal formation and virulence.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRRLKIGIRPQLIIIVCFASLFSLLILGIVTGIYFSANLKNLRLERLLVISQLKRTQVQQAIQYIAYQVMTVSEVDSLTVPLSNYRAGNNSKAVFSEAQNYLQQYVLTTDSFTAARLYDLDLQVVASSFDNMTLISESAQDVVYPLQPNRSMPPVLGTPSGLYFTGPIANNSDNFNSRYFMGITVPVLSNSSIILSQPSISGYLTIVAAAESIRSALNSTSEDDYQAMAVQPVYGDPQKGIDNLSQNAYNGDNEVIGFKLVFPVENSLLEAGTIYNINSSSSMKTALASNSGTATGVKSFFGKKVAIGFSRISVQDNLNWSIVIVQSNSVFNGPANKLRKITIGVVIGIGAFMCFVTFPLAVWFIRPITKLKEATEAITKYKKEKLNSVNSNSPTSGSGSGSGSGSGSRANSDSSADQSLSLDTGKRNSINSSSFSSSYSTGIRLPARIPRSKKIFKDELTELSEAFNIMTEELDKQYTHLEDRVKLRTKELEASKIQAEAANEAKTVFIANISHELRTPLNGILGMTSIAMEEEDPNVIHDSLKLIHRSGELLLHILTELLTYSKNTLNRSKLEKSNFQILEIVYQVRSIFNKLAHDQRVNFKILVKPNIFRKLIIYGDSNRIIQIVMNLVSNSLKFTPVDGSVSVSFKLLGEYDHERSKKLDYKKVCILNDSSSSTVAVPPPTPPSDTKPNPKPKSTPTPKPDPTRSHLVDHNNRSANTTSPLTPVRKPTNQTKNKSITNNVTKQNMKIRKKKKTNKNLHNNNNNNKNDNSDFLMNRRLSGSHKFNNTNDEELSPTAIEKNIDKYLTSSADSDNISVTTLSTVQYETTIFESQFKSKPLPALPVDAKPQVSGKIDENDVNDEDPSGGSIKDDDSEDTINEKQGISSSPSSSSSSNEKQENSPRSNDSTTVTVTRPRHNMMPSAQDFKSYPTFDKKPEYDSNMSNNEIVKNNRVYRIRNMYQPKVWVIQIEVTDTGPGIEPALQEKVFEPFVQGDQTLSRSYGGTGLGLSICRQLATMMHGTLTLKSTIGKGSTFTLTLPLPQTGEIMVPPEDMAEFCEDEFNPAAKINRKVAFEDGDIDTESQQQENPSSEEDTQGDRNVQSSTSSSPPNSSSTDSALPASDSSDIGGTNKSKTTSHGNNKNINAKKRIITNSSASSTKGTKRHTNNDGGGGVNGNHSDDNKDLTLTIDKPSLFTRGSTGTANSGTTSSHSDKKILYPTPTTTTTTTTTTDHTTVLDDISHLRVLVAEDNSVNQEVISRMLKQEGITNLTMACNGAKAIDFVKESIENNENFDLIFMDVQMPEVDGLKATKMIRKNLQYNKPIIALTAFADESNVKECLNSGMSGFITKPISKTNIKKVLVEFLSNEVVTS
The following text describes a protein:
Function:
Transcriptional repressor.
Miscellaneous:
MISCELLANEOUS: Does not bind methylated DNA; MISCELLANEOUS: The MBD3L proteins are encoded by strongly repeated regions of the 19p13 chromosome. The exact number of functional copies is unclear, and some of them may represent pseudogenes.
Subcellular Localization:
Nucleus. Note=Nuclear, in large foci.
Domain:
The N-terminal half of the protein mediates transcription repression.
Sequence:
MAKSSQRKQRDCVNQCKSKPGLSTSIPLRMSSYTFKRPVTRITPHPGNEVRYHQWEESLEKPQQVCWQRRLQGLQAYSSAGELSSTLDLANTLQKLVPSYTGGSLLEDLASGLEHSCPMPHLACSSDAVEIIPAEGVGISQLLCKQFLVTEEDIRKQEGKVKTVRERLAIALIADGLANEAEKVRDQEGRPEKR
The following text describes a protein:
Function:
Serine/threonine kinase involved in negative regulation of chemotaxis.
Miscellaneous:
MISCELLANEOUS: RckA kinase activity remains elevated unless the stimulus is removed and the kinase function is directly involved in delocalizing the protein from the plasma membrane. However, the membrane localization does not require a functional kinase domain and seems not to be essential for the kinase activation.
Subcellular Localization:
Cytoplasm. Cell membrane. Note=Translocates very rapidly to the plasma membrane upon stimulation by chemoattractant, but no polarized localization to the leading edge in aggregating cells.
Domain:
The RGS domain is involved in translocation to the plasma membrane.
Sequence:
MKTSKDSSNSNSNNNNNNNNNNNNNNNNNNGLNGTYSSKSLSPPTSPKQMSGNSIISNSTGNLSSGSGSGSSSGGNKKFINRSFNTFIDFIKKPARRNSKAHNTPPPYPEVDTGFGYFLELDSKPPKPFDEKDDPIHNSTGSTDSWEGDLNSSGGGGKQPQQTQQQSSGENLNNSSDRNNNSNENNQIVDDNSNVFNKGVVVQTVPMTEIGLFPVSLMMAQQRAEHPINVEDIESDVQTCSIPNSKPLYSSLGCSTNSSNSGSSISAPNITFQSFGISPVNNNNNNNNNSNNNSNSNSNSNSNSNNNNNNNNNNNNNNNNNNNNNNNNNSTVNSNNSSLNNSPRYLNSSSSPRSMQHLSSKITTTTTTTTTTTTTTSDDNNGNTNNNISNNNNIINNSNNNSNSNNNNNNNINNTNHKFKTMEKYFSSKENFPIPFPKLKDELGVIIENSSNKGYVGGNKGSEDRRKKIEQKKKQVPAPEMKATKEKFIETITDPTTLNSFRSFMENTQSNENLEFFLEVKRFNTIQDQVLLKHTCDDIWRRFFDDLAVTQLCVESSLKKLINNRRENPTHSMFNEVLDLLLDDIVCDAFRNYISSPFNPEWKSEFKKKFTNNTYSTTTQPINNFNNTNNNNNNNCSTPPNNYSSSPIKQSNINNNNNNASSSNIASSSNVNNNNNNSNGSNTSSSHHRERLDNIKGNRERVDSNGKERSIDNKDILSLLESNLSNHSNSSSNSNGKDKDKDKDKNENTTDNSNNNNNSNNNLNNLIIKNNFNNILQSPQIVSKINEIFKDSNNSQLSISITLDNDEDPTIFHLDESDMESLIEEVVKDNISVHTEISYSDVSIHKWIASGSSGRVYNGQYKGKDVAIKVLGPEVCVHFDLNEFKREVALMSIFKHDNLARCLGAGQYDDKYFHLTEYCHNGSLFSYLRDQRNNISFGQRLHFALGIARGMRYLHSMSIIHRDLKSMNILLTKRLKIKIVDFGTSRVANKYNMTTHVGTQAWMAPEIFTSRTYTNKVDVYSYAIILFEIFTRKSAYDENANINIPNMVMKGERPELPKDMQTSISNIIKKCWQQKPSNRPSFIKIVAYLESIIYPSVSNSLGLVASTSFSSSALWSGQILAQPKN
The following text describes a protein:
Function:
Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription (By similarity); Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes. Required for fusion of endosomes and autophagosomes with lysosomes (By similarity).
Subcellular Localization:
Cytoplasm. Lysosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Note=Colocalizes with TGFBR1 and TGFBR2 in cytoplasmic vesicular structures and most prominently in cortical vesicles.
Sequence:
MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGEEVLRMCVAVRKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAMEHQPPYIVAVLPRYVEIRTLEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPTLSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLNFLIENFKALAIPYLEHIIHVWEETGSQFHNCLIQLYCEKVQSLMKDYLLSLPTGKSPVPAGEEGGELGEYRQKLLMFLEISSHYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHVLKDTKMAKEYCHKHYDQNKEGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPQANLQAALQVLELHYSKLDTTKAINLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNSADT
The following text describes a protein:
Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
Sequence:
MDAWFSLIPAFTPHAPCFPLLYNLLEVIFKRLIQNMHKWNKVNGRSGKTSQPRSDQDSFLDEDLFPDQPSLSGRGSFSDQDSSTDGDSKEFVGLINQGSTCYLNALLQCLFLTPEFQEKISEEPPRSSTVEERLGQVFRKLKEKKSSVETRELTQCLKLSPTLQRDVTEIFHLLLFYLDRDDLREVFESTLMNTIVCQECQYAENVEAERKTLLVSLPINGDTVSVKAALDNFLQDTTFGDQDNMFYCGQCDRKTPANMKQTFTAVPPVLAIQLRRFEMRDGRLQKSNIPVETSQTLELQTIEKETKQYKLFAVCHHHGTHVGGHYTAHIRPAQHNRWYHFNDQSVTASEQFAEEEYKRSSYLLMYRQDRFKPRAERTGAAVMMTEPRKTTVKPNGDFQHLKRHSREAEPHTGSTGDKGAEKSGRAEGKRVEGAGVEKPSPDGEPPLNNSQGNPTEMSECFLTLNRTSSQPSRRSRPQGYHRAASPPSEFSGGVRRSWEELGYSSPQGISPDGIHQKDPLESETNPVQGPDGPQQIGPFAQKDSSELQWIKAQRFGTSSGLPQGTWGPPPVSPGNRNRTMGQEKEVHLMGRYHARDPEQSVSTESAADRGPESQEEQRPISRVEGAGIEKRSPDGDFPMGEAESHIGSTGDKGPERQEETMIPGNGVEGAGMEKRSPDRESPLSNLQGNPTEMSEYVLTLDHPSSQYTGGSRPRGYLRESSQPTEFSGGGGKSREELGHPSPRWIRPDSIHQKDPLESERSPETNPVQGPDGPQQIGPFAPKESLERETIEVLSFLEEWLKVLSFGTSSGPPQGICGPPPVSPGSRNGTMGQDAEGRYHPGDPEQSVSTESVADRGPESQEEQRPISRVEGAGIEKRSPDGDLPMDGAEPRTGNTGDKGLESQERMMPGQRGEGAGMEKRSPDRDLPMDE