lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.
Sequence:
MAGMGLSTGTARCYDWYMDYLKCMDERKEPMIALRREHCLEWLEDYNECLHREKERTRRQVIERERRAQLAGGSKPAGGGH
The following text describes a protein:
Function:
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
Subcellular Localization:
Cytoplasm.
Sequence:
MLYLASRSPRRHELLQRLDVPFQTLELDVPEVRAPGESPEHYVHRVALDKARAGLALVQADDAQAIVLGSDTEVVLGERVFGKPVDVDDAIAMLTVLAGRTHQVLTAVVLVGAQRPPLQALVVSEVTFDALDATRIAAYAASGEPMGKAGAYAIQGRAERFITHLSGSYSGVMGLPLFQTSQLLTAFGAH
The following text describes a protein:
Function:
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MTTLLDPQPQIDPSQKAMMVLKDSTITPAAMNVVGGYVMGFGFSLFGAMISAESTTQRMGTADFFRYSLKTAHRLGFSFAYFGFLFGGIEVALEKRRGRKDVWNATLSGGLLGGVYGCRYYKAPGLVGGTLGGAAVSLMLERVMDALGLAQR
The following text describes a protein:
Function:
Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasm. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein.
Sequence:
KMSAPGGNKSTNSEAWGSFDDNLIQGGGSAVIDMENMDDTSGSSFEDMGEMHQRMKEEEEVTEEAAATEEGEDGEFLGMKGFRGQLGRQVADEVWQAGKRQASKAFNLYANIDILRPYFDVEPVQVRNRLIESLIPVRMINFPQKIAGELYGPLMLVFTLVAILLHGMKTSGTVIREGTLMGTAIGTCFGYWLGVASFIYFLAYLSNAQITMLQMLSLLGYGLFSHCLVLFITYNVHFHSLFYILWLVIGGLSTLRMVAALISRTVGQTPRLLLCGTLAALHMLFLLYLHFTYHKIVEGILDTLEGPNVPPIQRVARDLPAMSATLVNATVKSIGATLQSH
The following text describes a protein:
Function:
Required for cilia biogenesis and maintenance in the kidney, the lateral line organ and eye. Appears to function within the multiple intraflagellar transport complex B (IFT-B).
Subcellular Localization:
Nucleus. Cell projection, cilium.
Sequence:
MSFRDLRNFTEMMRALGYPRLISMENFRSPNFPLVAEILIWLVKRYEPQMEIPSDVDTESDRVFFIKAVAQFMATKAHVKLNLKRLYQADGYAVKEMLKITSILYNAMKTKENAGGDQNNDENSKFKFDLGSKIADLKLARQLGSEITAKGAALFDLLGQEEDLRESRTAAIARPLEITETERAMRAAVKDVTESIQMTKDLLNNVSSDEASLEAKIEKKKQDLERNQKRLQTLQSVRPAFMDEYEKIEEDLEKQYQTYVEKYRNLSFLEQQLDDYHRVEQERFEEAEMAMKMRQNKLKEEEKRLMRSGVARDEDSDVDIPEDEGSDSDIDDGQQARPHHPRHTQISGRGGARFIGSMRGGDSEETEDSEIDVDDDDEDDDEDGEEDEEENEDLDEDNDSLEGSSGKPGRTNQSLHPQILEESDNDF
The following text describes a protein:
Function:
Flavoenzyme involved in polyamine back-conversion. Catalyzes the oxidation of the secondary amino group of polyamines, such as spermine, spermidine and their acetyl derivatives. Substrate preference is spermine > spermidine > N(1)-acetylspermine > N(1)-acetylspermidine > norspermine > thermospermine. No activity detected when putrescine is used as substrate. May play a role in producing hydrogen peroxide for secondary wall thickening through lignin formation during anther development (Probable).
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MTKPTTMAIFLSIVLLSMAQLPSLVAGTGRPRVIIIGAGISGISAGKRLSEAGITDILILEATDHIGGRMHKQRFAGVNVEIGANWVEGVNGEKMNPIWPIVNSTLKLRNFLSDFDSLAQNVYKDGGLCDAAYVQKRIDLADEADKSGENLSATLHPSGRDDMSILSMQRLNNHLPNGPSSPVDMVVDYFTYDYEFAEPPRVTSLRNTVPLPTFTDFGDDNYFVADQRGYEAVVYYLAGQYLEADKSGNIVDARLQLNKVVREISYSSTGVTVKTEDNSTYQADYVMVSASLGVLQSDLIQFKPQLPSWKILAIYQFDMAVYTKIFVKFPKKFWPEGAGREFFLYASTRRGYYGVWQEFEKQYPDANVLLVTVTDEESRRIEQQPDSQTKAEIMEVVRSMFPDEDVPDATDILVPRWWSDRFFQGSFSNWPIGVSRYEHDQLRAPVGRVYFTGEHTSERYNGYVHGAYLAGIYA
The following text describes a protein:
Function:
Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MVSSGEPAAAHELSEVPSENTIRILVTTDNHVGYNETDPITGDDSWQTFHEIMMLAREKHVDMVLQGGDLFHVNKPSKRALYQVMRTLRLACMGERACELELVSDPARVFNYNEFSEVNYEDGNFNIDVPVFAIAGNHDDASGQGLLTPMDLLQVCGLVNHFGKVGQTDNIELNPLLFRKGGTQLALYGLASIRDERLFRTFKEGNVRFNVPAGQADDWFNLMCVHQNHSSHANTAFLPEAVLPDFLDMVVWGHEHECIPHLMHNASKGFDVLQPGSSVATALSDGESKEKHVFILELQRGERPRLVPLPLTTVRPFIMEDISLKDVEGLKPHDKEAIAKYLVEQVERLIERARATSAERLHAARREGNGEDMLPLIRLRVNYAAGPGAPMDYQVENPRRFSNRFVGKVANANNVVHFYKRRQARRGGQKADAVADLDSLADYSNQTSDLEVQTLVKDLLTDMNLSLLPEIGLNEAVRKFVDKDEKNALKQFIDHEVDHEVKILATSKEVLQTDNIEDLKRLVKQVRYSARSPEDSANSLTEFNDFEMETPTVVAKRSQRSKKSSAGRKTASARTRKTGISAQFVTSDDSDETPIQISDDSDQNMILTDEEESSNKVDAASSSNSGKSTASKRPAKTRKPKADTAATKSGTTSRMPKTAALQALLNKKRGASAE
The following text describes a protein:
Function:
Magnesium transporter that may mediate the influx of magnesium.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDSKLWCALAVDKHEFLQLERASIIQRTGIHARDLRILDPLLSNPSTILIRERAIVLNLEHIKAIITRNEVLVRNPNNVDVVPVIEELRQRLKENEFEIEALKVALESINKFLGAQVEELEIHGFSALDDLLAKINRYNLKRVRTLKGGVAGLVARLQKVANKVNGELEDLLKEDDDNYFFPGAHEEVLEWHFMQVEGMITKLKTLSEHVIDTEKHIKIQIVNRRNGLIQIGLILNACVLAMSFFSMIASFFGMNLVPKRWQICCHPEFFNLEAWTFDLQKKEFT
The following text describes a protein:
Function:
May have roles in host-pathogen interaction, including establishment and maintenance of biotrophy, prevention of host recognition of the fungus and a barrier to host defense molecules.
Subcellular Localization:
Secreted, cell wall. Note=Cell wall and surrounding interfacial matrix.
Sequence:
MQTSFVALLAVAASLASALPHGGNSYEASLPEPTNLPEPTKLPEPVEGPYKPKPPILPEPIKDNYKPKTPILPEHVEGPYKPKLPEPTTGDPKNNTLPVPTCVDGKIKTHKVKSGESLTTIAEKYDTGICNIAKLNNLADPNFVDLNQDLQIPTDACEKDNTSCIKPDGTATCVKDGKKDGKDIYSVVSGDTLTSIAQALQITLQSLKDANPGVVPEHLNVGQKLNVPVC
The following text describes a protein:
Function:
Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. Required for normal cell growth and septum formation. Shown to actively O-mannosylate wsc1.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.
Sequence:
MDKQSTFQDPKEKHRIQRDVKLSRPRKRFSFLDYVVVIFLTVVAFCVRAQRLMNPAKVVFEELRYYNYAVDYVNNKLLMDVYPPLGKLLFSLVAALTGNKYELNTLDEPGQQYPFTDVAYSMRLFTCLLGSLLVPLMYGTVYFPTKSKTAASLAALFVIFDNGLITMSRYIMIEIPALYFMSLTAFYWSVYEAQQKRPFSLRWHTSLLSTGVALGLALSTKLSAMFTFGWLLILAAFHLWNLLGDLSVPMYRIVKHLFSYIFYLIGVPITVYLAVFAVHSHIAYKASVADAFLPPEHRHALAGNRFDDQFADVAYGSLVTIRNAIPEHGYLHSSELLYPEGTEQQIISLVDEPNQNALWIIEHEHSQDNNRSNIELLKDGSVVRLRHVMTGRALHSHEHKPIVSNNDWQLEASAYGGFGFEGDANDLFRIQILEKKSKHATSNGTVETLNTKFRLIHVFANCELMSSHRRFPDWGDYQREVTCCRNCVERSTTWFIESNYHDGLPSDSRKITYRKPGFLESFVEHNKLMWLKDRKMGDGHVYESSALTWPLLLGPLRFFYEQHLQVFFMGNPFVWYSVISLVAFFVIVQIFCLARWNLGYNDFGPSAFHYNYNIGKFVVAWLLHWAPYILETDRVFLYHYLPALYFGIAALGVSWSFLGNAVFGNRTAYKALSVIIMALMFLVYRLYSPFTYMTTLTKSSCRALELKGSWNFHCNTYLDNLSDYKFSSDAGETYFEKAAPHPFVYSEDTAKKSEGDTPLNKNLNDYYPSWDQRVEAGYKLAAQQKAEQEAREAAEKAASEAAERSSSEAAASSSSESVAAASVEAERLAMEADEFNGASETVDGASVEAERSAMEAAALNNAAESTEVVGSSPESVASEQEENVAESAQARVE
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH).
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MASTQGSSPRTNGKVITILSIDGGGVRGIIPAVILYSLEAELQRIDGPNARIADYFDVIAGTSTGSIVTALLTTPYTPPNPPANASKTNPPPNASITNRPREAKEIPEFYKKHGPAIFQKRKAPHNRYTTVDEEVGTIRLADTLTDVLIPAYDIEHRKLVTFSSHQERNKVPKSSLPLRQAVLGSAAAPTYFPRHHFQADGKIYNLVDGGMAANNPTLLAIREAINIFGSRDDNRYLVISLGTGAEGDHHDFVNLGSPIDWILDLKRGIPPLVSLLFETSADMVDTYTSIFLGGGQNSRHQFLRIQDYTLNPKQLKMDKATEDNFNNLINIAKQLLEKPVSFPSSWIGLEPTTTNRDALGRFANDLSKIRGDAAKKLSRR
The following text describes a protein:
Function:
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.
Subcellular Localization:
Cell membrane.
Sequence:
MKKHLTTFLVILWLYFYRGNGKNQVEQSPQSLIILEGKNCTLQCNYTVSPFSNLRWYKQDTGRGPVSLTIMTFSENTKSNGRYTATLDADTKQSSLHITASQLSDSASYICVVS
The following text describes a protein:
Function:
Transcription coactivator involved in regulation of the aflatoxin biosynthesis gene cluster with aflR. The ratio of the expression data between aflS:aflR plays a crucial role in the regulation of aflatoxins production. A high ratio, produced at a range between 17 and 30 degrees Celsius, corresponds with the production profile of aflatoxin G1 biosynthesis. A low ratio, produced over 30 degrees Celsius, is related to aflatoxin B1 biosynthesis. AflJ may act in aflR transport to or from the nucleus, thus controlling the availability of aflR for transcriptional activation of aflatoxin biosynthesis cluster genes. AflJ may also assist in directing endosomes to the cytoplasmic membrane for aflatoxin export.
Subcellular Localization:
Nucleus. Endosome.
Sequence:
MTLTDLETCAEEIATAARTLARDGHSGGYSAGLPDHLRAVQRTLIANASQVLALASQPADLVRQLALYNQLLACLRWLGEFQVLACIPLDESVPFEDVADIAGVPECRLRRLVRPLFTIGFLCEPSPGHVAHSVLSKQFVTQPALLDAILFMSETLAPSASAMGTQTRRFGASEQAGDSAWNMAVGSDSPFAACLQQRPKVKRQLGAYLSYVSSAIDAGVEDTLTRMNWQNLGMATVVHVGAQSPSLVVALAPQFPSLRFLVQTEAKAESGGHQPCLDNHGIPALKLASIPLHLRARITWGTRLSTATQPVLDAAVYLISIPFPSPQSPAMEITMRVAQALKAHVEVLRNNSDARLILTLPMSSATRSMDAAARAAVSLSDLSLLQLTNGGSLNMGEIRDLLRSRSDGLVVMREVRSPTNAVIAFEIQYRVDNDDNRY
The following text describes a protein:
Function:
Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (By similarity). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival. In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter. SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (By similarity).
Miscellaneous:
MISCELLANEOUS: Predicted models used for more than 20 years predicted 10-12 transmembrane segments. More recently, the structure of SLC9A1 has been solved and reveals that SLC9A1 possesses 13 transmembrane regions.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
Sequence:
MLLWSGICGLSPPRIFPSLLVVVALVGLLPVLRSHGLQPSPTASTIRGSEPPRERSIGDVTTAPPELAPESRPVNHSVTEHGMKARKAFPVLGIDYTHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKAVGETPPFLQSEVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYDRVGIVDIVLGFLSFFVVSLGGVFVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGHLLDKNHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKTLPTERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKINNHLTVPAHKLDSPTMSRARIGSDPLAYEPKADLPVITIDPASPQSPESVDLVNEELKGKVLGLSREPGRATEEEDDDEDHDGGLVMRTKEPSSPGTDDVFTPAPSDSPSSQRIQRCLSDPGPHPEPGEGEPFIPKGQ
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MVAPRPPTTSTINSSCTSSATSYVTYLTPTTSATQAYETPSRALLEEHTRVAMEISCGIRVPTSATIDLGVLASPNQGLQAGIDTLFRSWTDLANQEFKLLTSITKTSVAPHPDNLFVLLSMLNPLTDLFSLAKEKFLPVMKVLSLEDHADTLATGFDRALLALGSTVKSTIEMVQAWISGECILLISGYATTEIHHSGGVHEITRYVMMYIKLLSEHSALLTIVLNVTHGTGDIASTTEAPERIMADLMSRLESTLEKQSYYHITAMRWLFLVNNMHFIIQQPETLDVLEDDSWVPRDSIEFYIYMYLDVSWTPVQFCLQYRIKMIPACFKPPATRRFNTLFEKTYRAQSSWKVEDPLLRKHMRQAVIGKLIPAYRSFLEKQENKPAQLIEHTPEELEETLSELFEG
The following text describes a protein:
Function:
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Sequence:
MLYFVSRVQIIRLLTQNPQIWITWHVVFIFLFQIISTFSCSLQMIDTVTGAGVQSSAAQLKTLIDLEARYQPKLSGLRLIECAQDNGLRMTAKLRELEVKDLLSLSRFFGFSAETFSLAVSLLDRFLSVMKIQPKHLSCVGLCCFYIAIKSSEEEKNVPLANDLIRISQNRFTVSDMMRMEKIVMEKLYWKVKAPTTLHFLRLIHSHIQEQLDSEGKMILSIERLESQLKACHCSFAFSKIKPSLLAMALVCYEAQDQHDPEQIDQISEAVKSLQKLLNVRDGDLVCVRELVRKCLAEYATTKCFKPHCLRLRWTISGRTARQLKHSYYKIAHLPTIPESAC
The following text describes a protein:
Function:
Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin. Dephosphorylates phosphotyrosine and synthetic substrates, such as para-nitrophenylphosphate (pNPP), and has low activity with phosphoserine and phosphothreonine substrates (in vitro). Has also been shown to dephosphorylate MAPT. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates. Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane. Note=Colocalizes with glycogen synthase in punctate structures in the cytoplasm. Primarily associated with polyribosomes at the rough endoplasmic reticulum, and also detected at the plasma membrane. Under glycogenolytic conditions localizes to the nucleus.
Domain:
The CBM20 domain mediates binding to cytoplasmic glycogen and to Lafora polyglucosan bodies.
Sequence:
MRFRFGVVVPPAGAGAAPELLVVGSRPELGRWEPRGAVRLRPAGSAAGGGARALQEPGLWLGEVELAPGEAARDGAEPARVDTFWYKFLKREPGGALSWEGNGPHHDRCCTYNENNLVDGVYCLPIGHWIEATGHTNEMKHTTDFYFNIAGHQAMHYSRILPNIWLGSCPRQVEHITIKLKHELGITAVMNFQTEWDIVQNSSGCNRYPEPMTPDTMIKLYKEEGLVYIWMPTPDMSTEGRVQMLPQAVCLLHALLENGHTVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYIDEDALARAEEDFFQKFGKVRSSVCSV
The following text describes a protein:
Function:
Salivary chemokine-binding protein which has chemokine-neutralizing activity and binds to host chemokines CCL1, CCL3, CCL3L1, CCL4, CCL4L1, CCL5, CCL7, CCL8, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL20, CCL21, CCL22, CCL23, CCL24, CCL27, XCL1, CX3CL1, CXCL1, CXCL2, CXCL4, CXCL5, CXCL6, CXCL7, CXCL9, CXCL12 and CXCL14.
Subcellular Localization:
Secreted.
Sequence:
MHSTIAYVFVSALALFAALHGSTSARNHTEDNSTEYYDYEEARCACPARHLNNTNGTVLKLLGCHYFCNGTLCTAPDGYPCYNLTAQQVRTLTTYPNTSCAVGVCMKGTCVKNGTMEQCFKTP
The following text describes a protein:
Function:
Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.
Sequence:
MDQTCSLESFLNHVQKRDPHQTEFAQAVREVMTTLWPFLEQNPRYRHMSLLERLVEPERVIQFRVVWLDDKNQVQVNRAWRVQFNSAIGPYKGGMRFHPSVNLSILKFLGFEQTFKNALTTLPMGGGKGGSDFDPKGKSEGEVMRFCQALMTELYRHLGPDTDVPAGDIGVGGREVGFMAGMMRKLSNNSACVFTGKGLSFGGSLIRPEATGYGLVYFTEAMLKRHGLGFEGMRVAVSGSGNVAQYAIEKAMAFGARVVTASDSSGTVVDESGFTPEKLARLCEIKASRDGRVADYAREFGLTYLEGQQPWSVPVDIALPCATQNELDVDAARVLIANGVKAVAEGANMPTTIEATDLFLEAGVLFAPGKAANAGGVATSGLEMAQNAARLSWKAEKVDARLHHIMLDIHHACVKYGGDNKHTNYVQGANIAGFVKVADAMLAQGVI
The following text describes a protein:
Function:
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
Domain:
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Sequence:
MTLLVNQQEISDIDIGMPEYWTYKSEGAMNVVLSYTGPFNENLNGLVLRVKKQSNGGSNLEKEIELFNFVSKVMTPLLGEKYVFCGSMINITQDFLEKLDSLIFKQRPITRSTIRLDTKLPVAFLIMDLTKLDSFNISIDHDSILRSPVSHRLTSEQYQKQHPSHDKEKVICIEIKPKWGFLPSNSLKYMASETRDTKASTCRYCMHQHLKFQENSIGDISNYCPIDLFSGDPKRQEYSIKEMINHPQNNLKIYYNGVLSFTGSLGGGAERDQLSNCKILSSLLYENDIIRVSSNGQEEGVENIDIHSTIDAFSKLVTIILNRETILSSIKKVQLFDEYDIEGIYYIYNKLNGNESKNQSLDISKESQDQLNQLSTDQMKDIINRFMISCTAKDCSIMISFTLGKSITSIQDLNTNLTFINSLDETTNNNTDNNSSNNTVTYKIGVVDLDTKKQSAIPKYYELDREIVKTFKKSIKSIKSCK
The following text describes a protein:
Function:
Probable chromatin remodeling factor.
Subcellular Localization:
Nucleus.
Sequence:
MDMTSCVARRTRSRTESYLNSILNKSKGISGEEEDQSLGCVNSRTEKRRVNMRDACSPSPRKKKRRRRKDDDDDVVFVRTEYPEGKRDDENVGSTSGNLQSKSFDFGDRVCDFDADDRNLGCEEKASNFNPIDDDDDVVFVGTVQRENDHVEDDDNVGSASVISPRVCDFDEDDAKVSGKENPLSPDDDDDVVFLGTIAGENQHVEDVNAGSEVCDILLDDANLRGEEKTYVSDEVVSLSSSSDDEEDPLEELGTDSREEVSGEDRDSGESDMDEDANDSDSSDYVGESSDSSDVESSDSDFVCSEDEEGGTRDDATCEKNPSEKVYHHKKSRTFRRKHNFDVINLLAKSMLESKDVFKEDIFSWDKIAEVDSREDPVVRESSSEKVNEHGKPRERRSFHRVREKNHLNGESFYGGEKLCDGEETINYSTEDSPPLNLRFGCEEPVLIEKTEEEKELDSLWEDMNVALTLEGMHSSTPDKNGDMLCSKGTHDFVLDDEIGLKCVHCAYVAVEIKDISPAMDKYRPSVNDNKKCSDRKGDPLPNRLEFDASDPSSFVAPLDNIEGTVWQYVPGIKDTLYPHQQEGFEFIWKNLAGTTKINELNSVGVKGSGGCIISHKAGTGKTRLTVVFLQSYLKRFPNSHPMVIAPATLMRTWEDEVRKWNVNIPFYNMNSLQLSGYEDAEAVSRLEGNRHHNSIRMVKLVSWWKQKSILGISYPLYEKLAANKNTEGMQVFRRMLVELPGLLVLDEGHTPRNQSSLIWKVLTEVRTEKRIFLSGTLFQNNFKELSNVLCLARPADKDTISSRIHELSKCSQEGEHGRVNEENRIVDLKAMIAHFVHVHEGTILQESLPGLRDCVVVLNPPFQQKKILDRIDTSQNTFEFEHKLSAVSVHPSLYLCCNPTKKEDLVIGPATLGTLKRLRLKYEEGVKTKFLIDFIRISGTVKEKVLVYSQYIDTLKLIMEQLIAECDWTEGEQILLMHGKVEQRDRQHMIDNFNKPDSGSKVLLASTKACSEGISLVGASRVVILDVVWNPSVESQAISRAFRIGQKRAVFIYHLMVKDTSEWNKYCKQSEKHRISELVFSSTNEKDKPINNEVVSKDRILDEMVRHEKLKHIFEKILYHPKKSDMNTSFF
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Subcellular Localization:
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Domain:
Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
Sequence:
MLKGIEEISATKKRLKIEIPADIVEGEIQKALKEIQKKAKIPGFRPGKAPISIIEKKFGKEAEADVLEKLVSESYQKAVKETKIKPLLPPMAEDAIDIKRNEPLSFELVVEVRPDIENLNYDNIEVEEISTEVKEEEIEEVLQRLSKERGTYEPTEEPAMSEDLVVIDYTTDIGKEAKDYIYKLGAGPFPEDFSKAIEGKKKDETFSVTIDFPEDSIADFAGKKVNFEITIKEVKRRQNIPLEELHKELGFEDSDSLKKYIRQSLENAKKEQALEKQKFDILKKLLETYDFELPEGLVEMEMKRITEEYESLGLDITQHMDKISERAKRNVKAYILIDLIGEKEGVSVSEEELKQEIMNIARRYSITPQGVVQYYMSRDGSLEALQNSVFERKVFDILLQKSNRIKKEEAV
The following text describes a protein:
Function:
Might play a role in cell proliferation.
Subcellular Localization:
Secreted.
Sequence:
MAKLNTKLRGCSQESSVSSLLASGSLSGSRSDSAHSAHSSFVYKDQLYSSASEALQAYIDDFDLSREHPGANAVKVNTDGEIGNGLQFSSYVHIPDNAFVNLDPKQHFNPLYYRRETVNDMDAISLTTDDLLRLPADGCFSFPCVPPDHRPNKKYSGRQDSSDIKNSPSFYVDATSKSKNNIVPPYVYTNINGKKCGRPRTPKPINRENKCVSESSLSFPKESSFTEDSAERRLENYPRWLTSQKSDLSVSGVTSIPDVKYPIWLHNQDLLPEANTPRGYKLLNEDEYRPIHSYQTQRANQLLNKIDCFEYTFKPSNLTDSFSEYEGLGNEFKCQCDNPLLPGQSQKPFCGDKIELLILKAKKNLKQSAKDLPKPVEKDDSPCSLDKLEAERTWENVPVAFKSPVPVKADDSPQQSSRTQCVNAFLEDFLNGENQSSTLSGGKHHGPVEALKQMLFNLQTVQESFNKNKTTEPEEEIKQVSEDDLAKLQMKENMMPITRSLHKALQHLSRLRDLVDDTSGRQSPKK
The following text describes a protein:
Function:
Intracellular mono-ADP-ribosyltransferase that plays a role in different processes, such as protein translation and unfolded protein response (UPR), through the mono-ADP-ribosylation of proteins involved in those processes. Acts as an inhibitor of protein translation by catalyzing mono-ADP-ribosylation of ribosomal subunits, such as RPL14 and RPS6, thereby inhibiting polysome assembly and mRNA loading. Mono-ADP-ribosylation of ribosomal subunits is promoted by NMNAT2. Involved in the unfolded protein response (UPR) by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors. May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor. May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Sequence:
MEDIQTTVIELVKSDFLAADLRWSLFIGALDSYRHDSVLRPYPPGPHLLTADGEKDFSALESVAGRIPNMKMISEGKGSSGMQQHEWDLLKWVLEPNIFTVKSVNEDKKYHAIQELTGAASYEVKPSFIFEVEYHSAAGERFKTLSEQYDVLYAYHGSRWDNFHSITNNGLHAHMSKNTLYGEGTYLSSDLAVSLPYSPAGRGWTRSLIGSTLSCVAVCAMLDHPDVKCQVKDAQSHPSPSRSHAPDSMGGAVPERYYVVTNSEAVQIKYLLIFVDKKISQRASSRVSHRQRWIRENLFSLLLVGYIIVLIFVSFFNSRSFQSMWRRYVNS
The following text describes a protein:
Function:
Acts with E3 ubiquitin-protein ligase trim-21 to catalyze the 'Lys-48'-linked polyubiquitination of ced-1, promoting its proteasomal degradation to maintain appropriate ced-1 levels for apoptotic cell clearance.
Sequence:
MSVSKLNKMQFSDKMSNLALARVTRKCKEVANASDITEAGIHVEIKENNLMDIKGFIKGPEGTPYAGGTFEIKVDIPEHYPFEPPKAKFVTRIWHPNISSQTGTICLDILKDKWTASLTLRTVLLSLQAMLCSPEPSDPQDAVVAKQFINNYPMFTATAVYWTSYFANSKKDVEPDFNRKVGRLIEMGIRETEAIVYLSCNNWKLEQALQFIFD
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MSNNSTSGLSSLQKSVNQLRFEASFDRIMVSQAADDLKAFCLKNASKDPLIKGVPPNDNPFRPAKSCVLL
The following text describes a protein:
Function:
Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE associated with ER-derived vesicles (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Sequence:
MASNRGAGGSLYGGADPYRSREGLSTRNASGSEEIQLRIDPMHSDLDDEILGLHGQVRQLKNIAQEIGSEAKSQRDFLDELQMTLIRAQAGVKNNIRKLNLSIIRSGNNHIMHVVLFALLLFFILYMWSKMFKR