lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probable methyltransferase.
Sequence:
MIVNDLRNDDFNLNSNNNSNNNSNNNNNNNNNSNSNNNNNNNSNNNNNNNNNKSNNNNNNNNNNNNNNININDCDSIYSNNNSTLNRRSVTYYSLAIQCFNNNYFKLIKENNNHDNSEIIKQIKKLISIIYSNLSLVYINGCFVDKALDSIEKSIEYDKENAKAHYRKALCLRYMCRFKESLEALDNSLKTSTCRKDEGLKKLIDNEKDEVVSKLERLKVEEKSFKEKIIRDKEELGLFPMVSIEWQEGKGRCVIANNNIEKGSLVLRVSPYTASIEDIHLHKYCGSCFNKIINKEDRQKYKCKECKKFLFCEECSTDPVAIQYHHEECPIYQYFNRYHPDSNETRDIRLMSRVLLNALKEKKINNKNNNNTNKKDNNNDNNDNNDNNDNNDNSDNNDNSDSDSDGDSDNDSDSDGDNNRNNKKFKSSKLNIAKVTLSEYSKNNIPIKWRKEPFLFGTYNDIINLSCSNDGKIDKELREKFNRGVTTLMNLFEDIYGIDFLGDSFTREEIYEIYTIFLSNGHTVSNIFGKGYGHGFYPLGCYFNHSCVPNVTWYVDDNGMLAFRATRTISQGEELFLTYYDMFSTLDDRRPHLLDQYRFFCQCPQCEFQSKLSGLTCNQCREPLEEKHLYFELPLSNDDNGYRFTCSEGHKTFYPPEKGQEGQDAIINGDLRTYEFVNLLLRTNSFLDECRDALGSSSIPISFITPEIIGQTLNQRIANSFNIGGILVKYLKENIPPHQIYHEVLEKLQTAIKDNPLNLTLEEFSPTSICDLNLKLFRSIRKNNPEDERLEKIKDKIISILKIINGYPNNLSSKIIDNQLNKIK
The following text describes a protein:
Function:
Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53 (By similarity).
Subcellular Localization:
Nucleus. Note=Predominantly associated with chromatin.
Sequence:
MSQMLHIEIPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPGTVPPACFQQILSFCYTGKLTMAASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSPHCDSQTAMIEDASSEPQSPCNQLQPATAAYATSPSVPIPLLTRVKHEAMEMPPATGPGLASKRPLDTGPRDGVAVATGAAGTPGTAPLKLPRVSYYGVPSLATLIPSIQQVPYPQGERTSPGASSLPTTDSSTSYHNEDEDDDEAYDTMVEEQYGQMYIKATGNYAVQEKPEPVPLESRSCVLIRRDLVALPASLISQIGYRCHPKLYSEGDPGEKLELVAGSGVYITRGQLMNCHLCAGVKHKVLLRRLLATFFDRNTLANSCGTGIRSSTSDPSRKPLDSRVLNAVKLYCQNFAPSFKESEMNVIAADMCTNARRVRKRWLPKIKSMLPEGVEMYRSVMGASAASLPLDPEFPSAASQVFEQRIYAERRNDAATIVALRTDAVNVDLSTSANPAFEANEEVDGAGSVIQEVAAPEQLPADGQSSPQAFEQGNTSSSRPQTPVATATRRPEGTYAGTL
The following text describes a protein:
Function:
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that mediates the vacuolar degradative transport via the intracellular vesicle trafficking from the endosome to the vacuole. Probably regulates the PIN1 and PIN2 homeostasis through its interaction with SNX1.
Subcellular Localization:
Cytoplasm. Endosome.
Sequence:
MNTPMSLSAARGRMLPFLEKEKSEEESETLESSLLQLIDDNRRSSLQLREKTERSRKEAIRHAARTADLLVKAVNGGVEECFVNEKRIESEIRNLAITVAKFGKQTDQWLAVTHAVNSAVKEIGDFENWMKTMEFDCKKITAAIRNIHEDQQ
The following text describes a protein:
Function:
Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'.
Subcellular Localization:
Nucleus.
Sequence:
MQPLNMAEILDHRGVLTDGDDGPFRNLTNFYDMFSSNFPEGLRVLVFDEDPSYLLILERHLQKFQYQVTICNEVNKAMHTLRNHRNRFDLAMIQVNNAEGDIFRFLSEIGSEMDLPIIIISEDDSVKSVKKWMINGAADYLIKPIRPEDLRIVFKHLVKKMRERRSVVTGEAEKAAGEKSSSVGDSTIRNPNKSKRSSCLEAEVNEEDRHDHNDRACASSAKKRRVVWDEELHQNFLNAVDFLGLERAVPKKILDVMKVDYISRENVASHLQVTFLIYNIIVHFQQHFCFYS
The following text describes a protein:
Function:
May have antimicrobial activity.
Subcellular Localization:
Secreted.
Sequence:
MWFTYTFAMLLVAGYVSAYGSGAPQSACQDMIPRHPVGPQNTSAPYIITTSTKVVKAGTPMQVTISGKKPENTMRGILLQARQGDKIVGKFTLDDNDSFAQLLDCGEPGNAITHKRHPPEFDKQTVTFTWTPPADLNDNIRFRATIAYSGAVFWLGVESPVVKVVA
The following text describes a protein:
Function:
Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVALISLSFGGAIGLMFLMLGSILALFVLFFYILSPIPYCVARRYVDCSDPATNACKELALFLTTGIVVSALDSRYGEGDSVRTLMETGALSFNRQPCQQRPDNQRKVAGVGASGLRLGCLPLATIICSFPGVPTTCRTVGRFLFLEGELVPLPLVFSPFRWVLAVFVSCRCASISTRPFAQVHR
The following text describes a protein:
Function:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules.
Sequence:
MELAQEARELGCWAVEEMGVPVAARAPESTLRRLCLGQGADIWAYILQHVHSQRTVKKIRGNLLWYGHQDSPQVRRKLELEAAVTRLRAEIQELDQSLELMERDTEAQDTAMEQARQHTQDTQRRALLLRAQAGAMRRQQHTLRDPMQRLQNQLRRLQDMERKAKVDVTFGSLTSAALGLEPVVLRDVRTACTLRAQFLQNLLLPQAKRGSLPTPHDDHFGTSYQQWLSSVETLLTNHPPGHVLAALEHLAAEREAEIRSLCSGDGLGDTEISRPQAPDQSDSSQTLPSMVHLIQEGWRTVGVLVSQRSTLLKERQVLTQRLQGLVEEVERRVLGSSERQVLILGLRRCCLWTELKALHDQSQELQDAAGHRQLLLRELQAKQQRILHWRQLVEETQEQVRLLIKGNSASKTRLCRSPGEVLALVQRKVVPTFEAVAPQSRELLRCLEEEVRHLPHILLGTLLRHRPGELKPLPTVLPSIHQLHPASPRGSSFIALSHKLGLPPGKASELLLPAAASLRQDLLLLQDQRSLWCWDLLHMKTSLPPGLPTQELLQIQASQEKQQKENLGQALKRLEKLLKQALERIPELQGIVGDWWEQPGQAALSEELCQGLSLPQWRLRWVQAQGALQKLCS
The following text describes a protein:
Function:
Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Domain:
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Sequence:
MASDFARYIANLRQSLFDEKLLDRHFLQLERLETNNEGYLEDVCADYFKDAAKFVGLMVPELQGHPYDAHSIESLLHRFKGMATGMGAIQVTHQIDCMREHLKRGDFEACKIALERIKQENEFLQFKLDNYFKLRKQAPPAEIEDQPEYGYMDTDSE
The following text describes a protein:
Function:
Transcription factor involved in inflorescence stems gravitropism, probably by regulating starch accumulation in amyloplasts of graviperceptive cells. Required for stem circumnutation movements. Regulates lateral organ morphogenesis and gravitropic responses. Acts cooperatively with IDD16 to control silique and branche orientation. Involved in the establishment of auxin gradients through the regulation of auxin biosynthesis and transport.
Subcellular Localization:
Nucleus.
Sequence:
MRTDQVMLSNKNTNTCCVVSSSSSDPFLSSSENGVTTTNTSTQKRKRRPAGTPDPDAEVVSLSPRTLLESDRYICEICNQGFQRDQNLQMHRRRHKVPWKLLKRDNNIEVKKRVYVCPEPTCLHHNPCHALGDLVGIKKHFRRKHSNHKQWVCERCSKGYAVQSDYKAHLKTCGTRGHSCDCGRVFSRVESFIEHQDNCSARRVHREPPRPPQTAVTVPACSSRTASTVSTPSSETNYGGTVAVTTPQPLEGRPIHQRISSSILTNSSNNLNLELQLLPLSSNQNPNQENQQQKVKEPSHHHNHNHDTTNLNLSIAPSSSYQHYNNFDRIKEIMASEQIMKIAMKEKAYAEEAKREAKRQREIAENEFANAKKIRQKAQAELERAKFLKEQSMKKISSTIMQVTCQTCKGQFQAVAVPAATADETSLVVSYMSSANTDGELENGF
The following text describes a protein:
Function:
Aldo-keto reductase (AKR) that displays broad substrate specificity in vitro. Is able to reduce the standard AKR substrates DL-glyceraldehyde, D-erythrose, methylglyoxal, p-nitrobenzaldehyde, benzaldehyde and butyraldehyde, in the presence of NADPH. Cannot use NADH as a cosubstrate. Does not act on glucose, 2-pyridine carboxyaldehyde, fructose and xylose. The physiological function of this enzyme is not clear. May play a role in bacterial stress response and/or in detoxification of reactive aldehydes.
Sequence:
MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAALDQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRARIVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIEQMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEEYTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADIALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI
The following text describes a protein:
Function:
Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.
Sequence:
MALLEHTLQKKLDRTDSVHTPCYCEENVYLLVKKLAETGRAAADYSDLFIVFVSNERKQVLMWRQQAGSEGDGACVWDYHVFLVQKRVESEGGSLIWDLDTTLPFPVRFSTYYDEAFRPSIRLYKEFERLFRVVPAQTYLQHFSSDRSHMRRPDGSWMAPPPPYPPILKVEGVGHALIDYVNVKLADCDGPKEEETEQKRVDVGPAKLQGQKIRTFGIVHTESTFVCCFL
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MENLRPVRCSENEEIGLYLWRKRQEMVESNGLSENLDQTLSKAYRSICDAKTPIKTLKDLSQIKGVGKWILRLMQGFFQESVADVPSTTNEAHAKGKKSKEPKRYVPKKNSVAYALLITLYRAMTNGSSYMKKQELIDAAEASGLSRTSIASDKSKQPGQFGISSRDWYTGWNCMKSLISKGLVVKSSCPAKYMLTQEGQEAARECLLRSGSIDLEPAKATCRSHSALDGQSASPVDLTLQSASVSCQTEMIDIPTEYVDRYKQADFLDSDHDSANLEKCSYSTAETCMPIVLDSIANIPVGDARCRNSVYADAAQSSFNLRACTSFDSPMHKPSANDATKGNDNAIAMPPYRSGEKFEDIYDVILILDDRENFGSRSRKIVDNIHTQFNILVEFRRLPVGDGIWIARHRGCNTEYVLDFIVERKRVDDLCRSIRDNRYKDQKLRLQRCGLQKLIYLVEGDQNCLEAAESIKTACFTTEILEGFDVQRTSGFADTVRRYGYLTKSIIQYYTMHFIDKAMCSRVCPSYDEFVKKCQDLEKMTISDVFALQLMQVPQVTEEIALAVVDLYPTLLSLAQAYSHIEGDLRAQEELLKNRSKIISASASRNIFKLIWGR
The following text describes a protein:
Function:
NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, it is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting axon destruction. Involved in the down-regulation of the tracheal immune response to Gram-negative bacteria. This is likely by mediating Tollo signaling in the tracheal epithelium.
Subcellular Localization:
Cytoplasm. Cell projection, axon.
Domain:
The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Sequence:
MKAAEIKRDLTNIQKSMSEINDLAKERITGGPGSISTTSASAITAPSTMSQTTTSRLAPKLTSAHPSIDDLRGLSRQDKITQLQKKIRASFENLVDHDDSNVIVTLPDDDDCPHNHFGSGLNLTHPTAAQLSASGLSGSSKTIDTIKFQEKSMKTESKTKVVTDGFSSEQATSNSAEMKRLQAGDIDYQESKGASAMRNRLEVDGVKTEENAAVIKEALSLRTGDITQQASNNVAASSITVQSENFSADKKAISQSQQSQTMTSNGIISQEKHVSSASQANYSMSHKGVSSTGSSMITSSSQMSAMNGQMLKLADLKLDDLKSLTAGSGQQEIEQTINKYSNMLTSIVSSLQEDERGGSAITVHDVGGKKSQYLEKINEVIRRAWAVPTHGHELGYSLCNSLRQSGGLDLLMKNCVKPDLQFSSAQLLEQCLTTENRKHVVDNGLDKVVNVACVCTKNSNMEHSRVGTGILEHLFKHSEGTCSDVIRLGGLDAVLFECRTSDLETLRHCASALANLSLYGGAENQEEMILRKVPMWLFPLAFHNDDNIKYYACLAIAVLVANKEIEAEVLKSGCLDLVEPFVTSHDPSAFARSNLAHAHGQSKHWLKRLVPVLSSNREEARNLAAFHFCMEAGIKREQGNTDIFREINAIEALKNVASCPNAIASKFAAQALRLIGETVPHKLSQQVPLWSVEDVQEWVKQIGFNDYIDKFNESQVDGDLLLKLNQDNLRADIGIGNGILLKRFERELQNLKRMADYSSKDTAKMHQFLSEIGTDYCTYTYAMLNAGIDKCALPHVNEDMLMTECGIHNSIHRLRILNAVKNLENSLPSSSEENMAKTLDVFVSYRRSNGSQLASLLKVHLQLRGFSVFIDVERLEAGKFDNGLLNSIRQAKNFVLVLTPDALHRCINDEDCKDWVHREIVAALNSNCNIIPIIDQQFDWPEVERLPEDMRSVAHFNGVNWIHDYQDACIDKLERFLRGEKNIDRIAAMVPGTPGSVSYQRMHSNDSDYQSGGAGAGSGAGTGGGGGGGVTGSVVDGLMVAANGSGQANHQANRYRQSPSPARQRGSTSQLSGYSRAPSKRSQILTPYRTQQAALLHKTGAGSASMQNMMPLAYLPPRRSSAAGLGHGSGSGMGSGYRSHSVDGLLDQAGSTPEQRIAAAAAKVTAGSTALTNASSTSTLQPEEEVTDAALNDSVTRRDKHTLSPPGNVQQHRKSRSLDHILSKQTLAELLPPSSELADGTQSMQNLAIPMTPQPQRRDTSSSSKSPTPERPPQPAMERVRERQSPEGVSATESEREDQPEECLRHGNQQRASASVHRGASLTSNKTSNSSLGSNFSAGGNNKTIFNRTMKKVRSLIKKP
The following text describes a protein:
Function:
May be involved in iron transport and iron homeostasis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPASVSMSKLLSPPYYTSYTSLRRLPRHAVPARFARDPGGPRFAQPRSLRPSSRFAGSCHTGASSEISLAVDGGEGTSAGGYEDGGLPFVNLSSSIFQTELGLLKDDALPAPQKGSRGEDHLESTPAYPAAMNALYAAFFAGNATEHLWNFTWPAAVATLHQSLLPVAVLGFFTKLVVFIAGPLLGELVSSLPRIPVYRSLTVIQTAAHLVSASMIAHAFTMPRASTTMKLLLRPWFAMLVVSTAVDRLSCVSLGIIAERDFVVQLAGTGRPIALARANATLSRVDLICETAGASIFAFLLAKNDPLTCIKLSCLISLSALPVHIFMAGTMNRLADGVFDHSEQRSSHAASSFHIWRIVEEAWATIRQGWTEYISQPVLPASLAYVLICFNVALVPGALMTTFLIHHGTTPLVLGAFGVSSALMGILATFMTPSLVKELGLLKAGAAGIIAQSVLLSAAVLVYLTGSISRRGALFAFLGLIVVSRLGHMAYSVIGLQVVQTGNPMAKAKLIGATEVAVGSLAELGTMAVAMAARDVSGFGAVAVLSAAAVAAAACLYCGWLANPHRRSENALSALMTCE
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
Subcellular Localization:
Peroxisome membrane.
Sequence:
MASQNGGIPENVPELGPAAPRESLISTAVKFLQNPQTQSSPLDQKKKFLVSKGLTENEIEIAVSRSNISSQPIPITQLTQVNAVPPKPVSAWKNIQAYSSMAIVIGGFVYAFFTIYKKYIEPLFMKHRGEQRDQMVELEMGVKELNTEVTRNLKSLEGVIAEIRDEVKEHAQVMQRVSTQLTVMKNENGNNGNDATIRDLQAQISSLKGLLLNTKQFPAAPVIPSWQIPSNSKPQQDVRSHVENGLMSGQPSNGRVDELESHETNHVNDEESSLELNQSRTVDHKPDDVNLQVDGISHTSLYNNYKTPNSSISSEMAQDKESELD
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MTTNHRPTLESKRGKAESISNTIFHSRSLPQHTSLKYRGDIRKPKVDTKIGKQAVEELKKDLLLNEGKLEDSLKINKSLTDGDHSMDEHISKTIDNQEDERDYNRQEYDERSIGKEEYSGSEDDSGDDSEDETAQLMEELAKIKKERQEEQEKLELQNKLDKTKVSNPLVQVVGASTEANFKIKKSWRDSTAFKKQNSQNKNDDETFTNDTLNSEFHQNFLTKYIR
The following text describes a protein:
Function:
Glycophorin A is the major intrinsic membrane sialoglycoprotein of the erythrocyte. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
QTIATGSPPIAGTSDLSTITSAATPTFTTEQDGREQGDGLQLAHDFSQPVITVIILGVMAGIIGIILLLAYVSRRLRKRPPADVPPPASTVPSADAPPPVSEDDETSLTSVETDYPGDSQ
The following text describes a protein:
Function:
Is the sulfur donor in the synthesis of the thiazole phosphate moiety of thiamine phosphate.
Sequence:
MQILFNDQAMQCAAGQTVHELLEQLDQRQAGAALAINQQIVPREQWAQHIVQDGDQILLFQVIAGG
The following text describes a protein:
Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MAGNKMFCRPRRQRLSHSRRAELQFPVSHLERCLRESQHARHLSSTTPVFLAGVLEYLTANILEKVGKEVKNSCRLCITPEHVKRALQKDEQLRWILELEDDTHSQVEEMPQSEEEEEEEEEKEEEMVVLVVMGGRRRRRRRRRRKDS
The following text describes a protein:
Function:
Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.
Sequence:
MASETRKVVVHLRATGDAPILKQAKFKFVYVNSAFSPNPDELVSDLYNNFGFDGKLVVNYACSMAWG
The following text describes a protein:
Function:
Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.
Subcellular Localization:
Cytoplasm.
Sequence:
MSIFEIENIINKILLPQEKELIESEFMCQICKKLIFNRYVYQCRIGDWYCDSCVKSKVLKKKRCSIYELNNALIDENKDISEEDENRCSQKITISELNGHIETCQFRFVKCKNQGCEMELRFKDLQVHSDKCGYEVIMCQLCNHEVIRSKLEHH
The following text describes a protein:
Function:
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
Sequence:
MISMKPRYKPDWESLREHTVPKWFDKAKFGIFIHWGIYSVPGWATPTGELGKVPMDAWFFQNPYAEWYENSLRIKESPTWEYHVKTYGENFEYEKFADLFTAEKWDPQEWADLFKKAGAKYVIPTTKHHDGFCLWGTKYTDFNSVKRGPKRDLVGDLAKAVREAGLRFGVYYSGGLDWRFTTEPIRYPEDLSYIRPNTYEYADYAYKQVMELVDLYLPDVLWNDMGWPEKGKEDLKYLFAYYYNKHPEGSVNDRWGVPHWDFKTAEYHVNYPGDLPGYKWEFTRGIGLSFGYNRNEGPEHMLSVEQLVYTLVDVVSKGGNLLLNVGPKGDGTIPDLQKERLLGLGEWLRKYGDAIYGTSVWERCCAKTEDGTEIRFTRKCNRIFVIFLGIPTGEKIVIEDLNLSAGTVRHFLTGERLSFKNVGKNLEITVPKKLLETDSITLVLEAVEE
The following text describes a protein:
Function:
Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins; Interacts with target proteins during translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation and facilitate correct glycosylation.
Subcellular Localization:
Membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MVAKQRIRMANEKHSKNITLRGNVAKSTRGTQEEKAVVGPWLLALFVFVVCGSAIFQIIQSIRMGM
The following text describes a protein:
Function:
May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTEINDELAIRFRHNVVFYHLHLFSNPSAVGAQTASDISRTKERVWSGLATRRPWRELADVRAIRLPPILGVAYLRIRSNAAYFDMNYVIVVHPVVFLSPLWHPTSLMVFLYFVRNEPLVALVRTCVNDRTILIALSMVTLVLLLRTKATSDVLISRLVGLRMVLIHAALLRTEDLVLKEEAAGSETWYAAVPQSQPISAAFTDAANPNRPAIAE
The following text describes a protein:
Function:
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
Sequence:
MPSVESFELDHTIVKAPYVRHCGVHNVGSDGIVNKFDIRFCQPNKQAMKPDVIHTLEHLLAFNLRKYIDRYPHFDIIDISPMGCQTGYYLVVSGTPTVREIIDLLELTLKDAVQITEIPAANETQCGQAKLHDLEGAQRLMNFWLSQDKDELEKVFG
The following text describes a protein:
Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MALRTLASKKALSFALGGAARPLAASARGVTTVTLPDLSYDFGALEPAISGEIMRLHHQKHHATYVANYNKALEQLDAAVAKSDASAVVQLQGAIKFNGGGHVNHSIFWKNLKPISEGGGEPPHGKLGWAIDEDFGSFEALVKKMNAEGAALQGSGWVWLALDKEAKKLSVETTANQDPLVTKDASLVPLLGIDVWEHAYYLQYKNVRPDYLNNIWKVMNWKYAGEVYENVLA
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDISKMNRYTAPVNFASLPLLTTFLCGVGLLLLATFTMIQVTSTKYNRNLLKELFIAATSSVFLGFGSVFLLLWVGIYV
The following text describes a protein:
Function:
Voltage-dependent potassium channel involved in the excitation of muscles operating egg-laying and defecation.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLDACSFNRFDSNRSSARRFSRRGSDYFGDKGISMDERIVLNVGGVRHETYQATLKKIPATRLSRLTPSLANFDPLLNEYFFDRHPAVFAMILNYYRTGKLHYPTDVCGPLFEEELQYWGLDASDTEPCCWMQLLHAKDTQETLAVLDRMDADHEDDPQLREQDTMKKFGWEEDYFQGKRTRWMKLKPQMWSLFDEPYSSQAAKLIAGISVLFIFISIFSFCLKTHQSFRLPVLIGQNITMPGGVVQPSIERVSTEPLPIFGQIEMLCNIWFTLELIIRFVFCPSKIRFFKSPLNMIDLVATLSFYADAMMVRVVEDEPKDVVEFLSMIRIFRLFKLTQHHQGLQILIHTFRASAKELILLVFFLILGIVIFAALVYYAEKMEANPNNQFQSIPLGLWWAICTMTTVGYGDMTPHTSFGRLVGSLCAVMGVLTIALPVPVIVSNFAMFYSHNQARDKLPKRRRRVLPVEQIRLQARRHAAVLEPSASQGGLGGGQAIRRRNMPILIDQNCCDEENHNHKHREKSENSDEGTNSSSTTGVDTVVKLGPSETAITTTIIS
The following text describes a protein:
Function:
ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MVSESCSRNYNHPYTPYDIQIQLMDAIYNTIENGYKIGLFESPTGTGKTLSIICSSMTWLRTFKRNNTFLETNNEVEDVYESESEEDEPEWVKKAYQSSIVNRSKNKLIEYEHYLDKIEKEHAQNKRKEEELEIKVHKRRKAMTAAGTDLSEESYLPMDYYSDSEVGKIEDQNLAITKEINRLLKKVENKEEVSYINECPIKIFFSSRTHSQLNQFSSQLRLTNFQASFEDLEERTKYIPLGSRKQLCINEKVRSKGNDQSVNDACLDLQRETNGCQYLPKNYMMSSVTKEFADLSLAKIRDIEDLNELGIELNICPYYSVRKGIEMTEIISLPYQMIFQDTTRKILNLDIKDSIIIIDEAHNIIDVITSMYSIKITSDQLNKVIKSLKIYLNKFLKRLNSGNRINLMKLIKICQILLKFLNTNSEKVKSGDEVQIQDIFKDSTGDLVNIHKLDQFLTKSKIAYKIESYIEKTEMETDNGEKKGRITNSGGSSSSSSSSNPLLFTIIKFLRTLTNLSKEGKFFWDNENGTISLNYMLLDPSAVFKEIVDQAKCVLLCGGTMEPMSDYMDYLFPSVPTNKINTFACGHVIPKENLQVFPISQWNDTNFEFSYQKRNDSKQLMALGEFLIEITKRVPYGVVIFFPSYKYLDQVLQFWRDTKILTSIESEKTIFREPKDPSNVEKVLNEYGYLIQTERKGAILFSVVGGKMSEGINFSDDLARAVIMVGLPYPNAYSGEMVTKRKYIETSELSNGGTTTDAKEKSRNYYENLCMRAVNQSIGRSIRHINDYSIIYLVDRRFSTPRIQNKLSQWVKERISITTTNNNNNNSIYIMESTTDFFNIIR
The following text describes a protein:
Function:
Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses or by promoting the activation and maturation of some APCs. Interacts with the essential precursor of cell wall synthesis lipid II to inhibit bacterial cell wall synthesis. Inhibits adenovirus infection via inhibition of viral disassembly at the vertex region, thereby restricting the release of internal capsid protein pVI, which is required for endosomal membrane penetration during cell entry. In addition, interaction with adenovirus capsid leads to the redirection of viral particles to TLR4 thereby promoting a NLRP3-mediated inflammasome response and interleukin 1-beta (IL-1beta) release. Induces the production of proinflammatory cytokines including type I interferon (IFN) in plasmacytoid dendritic cells (pDCs) by triggering the degradation of NFKBIA and nuclear translocation of IRF1, both of which are required for activation of pDCs.
Subcellular Localization:
Secreted.
Sequence:
MRTLAILAAILLVALQAQAEPLQARADEVAAAPEQIAADIPEVVVSLAWDESLAPKHPGSRKNMACYCRIPACIAGERRYGTCIYQGRLWAFCC