lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MADALKDVPFKTVQVDALVAIKIATASGKAFPSLATGSLVGMEKNGVLEITNSFPYPEINTASADGQNDTAANLSAAAPRAKQNIAYGNEMIKFLREVNVDANNVGWYTSTSMGNFVNLNTIENQFYYQSQLNERTVALIYDVSRSSQGTLNLRAYRLSPSFVTAYKEGKFTTESLQKSSLRYQDILVELPVTVHNSHLLTSLLHQLPSEAPKEELSFPPNLAALQQDPNTPLPPLFPNYDALDLSIDPFLEKTCDLLLESIENHHTELNNYQYYQRQLAREQTKITAWQQKRKAENAARTASKQPLLPEDEWQRLFKLPAEPSRLETLLNSRQVEQYSRQVDGFAAGVTSKMFAVKSNLLPGE
The following text describes a protein:
Function:
Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.
Subcellular Localization:
Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin.
Domain:
The DOCKER domain probably mediates the GEF activity.
Sequence:
MAPWRKTDKERHGVAIYNFQGSEAQHLTLQIGDVVRIQETCGDWYRGYLIKHKLSQGIFPTSFIHLKEVTVEKRRNIENIIPAEIPLAQEVTTTLWEWGSIWKQLYVASKKERFLQVQSMMYDLMEWRSQLLSGTLPKDELKELKQKVTSKIDYGNKILELDLIVRDEDGNILDPDKTSVISLFHAHEEATYKITERIKEEMSKDQPDYGVYSRISSSPTHSLYVFVRNFVCRIGEDAELFMSLYDPHKQTVISENYLVRWGSKGFPKEIEMLNNLKVVFTDLGNKDLNRDKIFLICQIVRIGKMDLKDINAKKCTQGLRRPFGVAVMDITDIIKGKAESDEEKQHFIPFHPVSAENDFLHSLLGKVIASKGDSGGQGLWVTMKMLVGDIIQIRKDYPHLVDRTTVVARKLGFPEIIMPGDVRNDIYITLLQGDFDKYTKTTQRNVEVIMCVCTEDGKVLPNAICVGAGDKAMNEYHSVVYYQVKQPRWMETVKVAVPIEDMQRIHLRFMFRHRSSLESKDKGEKNFAMSYVKLMKEDGTTLHDGYHELVVLKGDSKKMEDASAYLTLPSYRHPVENKGATLSRSSSSVGGLSVSSRDVFSISTLVCSTKLTQNVGLLGLLKWRMKPQLLQENLEKLKIVDGEEVVKFLQDTLDALFNIMMEHSQSNEYDILVFDALIYIIGLIADRKFQHFNTVLEAYIQQHFSATLAYKKLMTVLKTYLDTSSRGEQCEPILRTLKALEYVFKFIVRSRTLFSQLYEGKEQMEFEESMRRLFESINNLMKSQYKTTILLQVAALKYIPSVLHDVETVFDAKLLSQLLYEFYTCIPPVKLQKQKVQSMNEIVQSNLFKKQECRDILLPVITKELKELLEQRDDGQHQAEKKHCVELLNSILEVLSCQDAAFTYDHIQEIMVQLLRTVNRTVITMGRDHALISHFVACMTAILDQMGDQHYSFYIETFQTSSDLVDFLMETFIMFKDLIGKNVYPGDWMAMSMVQNRVFLRAINKFAETMNQKFLEHTSFEFQLWNNYFHLAVAFITQDSLQLEQFTHAKYNKILNKYGDMRRLIGFSIRDMWYKLGQNKICFIPGMVGPILEMTLIPEAELRKATIPIFFDMMLCEYQRTGAFKKFENEIILKLDHEVEGGRGDEQYMQLLESILMECTAEHPTIAKSVENFVSLVKGLLEKLLDYRGVMTDESKDNRMSCTVNLLNFYKDNNREEMYIRYLYKLRDLHLDCENYTEAAYTLLLHTWLLKWSDEQCASQVMQTGQQHPQTHRQLKETLYETIIGYFDKGKMWEEAISLCKELAEQYEMEIFDYELLSQNLTQQAKFYENIMKILRTKPDYFAVGYYGQGFPSFLRNKVFIYRGKEYERREDFQMQLLSQFPNAEKMNTTSAPGDDVRNAPGQYIQCFTVQPVLDEHPRFKNKPVPDQIINFYKSNYVQKFHYSRPVRRGKVDPENEFASMWIERTSFLTAYKLPGILRWFEVVHMSQTTISPLENAIETMSTVNEKILMMINQYQSDESLPINPLSMLLNGIVDPAVMGGFAKYEKAFFTEEYSREHPEDQDKLSHLKDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFEDRRVGRPRSMLRSYRQMSVISLASMHSDCSTPSKVPAESFDLESAPPKTPKVEEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAATESDLKRLSRKQEFMSDTNLSEHAAIPARVSILSQMSFASQSMPTIPALTLSVAGVPGLDEANTSPRLSQTFFQVSDGDKKTLKKKKVNQFFKTMLASKSSEESKQIPDFLSTNM
The following text describes a protein:
Function:
Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
Subcellular Localization:
Bacterial flagellum basal body.
Sequence:
MSINDLPVLSALRTKMQWHQERQRVLSENVSNSDTPKFRPRDLVEPKLDRAGAVTGSMGPLAMTVTSASHMTPSGAASGFDQNRNAGFETRPAGNAVNLEEEMMKAASNQMDYAAATSLYSKSLRLLKTAIGKG
The following text describes a protein:
Function:
Catalyses the transfer of galactose onto proteins or lipids.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MSRTCRNDCNMVLIFCLCCVALLTVLTFYIDLFRTQPFKPPSSLKKSSGSRPRAQNVKEKEKPASLSPCPSSMDLPDEQLTPRKDATTCEKVNVELLGNSLQKTLEATDIANKSLPSIIMKRRSIKEVNSSIDQTISEMNLAVDFDDYRLLPGGHWIPLSCKPLWKVAIVIPFRNRFHHLPIFLRHIVPFLKRQKLEFSIFISEQRNDIRFNRAMLMNVGFVEALNFINFDCVVFHDIDHLALNVQNYFGCENMPRHFISGEAIWRWKIPYTKLFGGVTGITKDQFYTINGLSNVYWGWGGEDDDFFNRVYTKNLTRTRPEGKIGYFDSVRHAKKESSVSNEARVCLLKSYKQRMPTDGVSNLKYEPPTIELHPLYTNISVNIQKLPWDPSWKRCKGQ
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MIAPTEPTEGNSRASVLEFDEEGYVESEDEDFDPSKPADDDKEEELSDKSDGDYQEADEEAEKYDYSHIESSEGGLVSTRNARRLQHEREQREKYEHFEMQGVSSRAGELWAQLQEESQARLHDTSSVMHAGGEAGKDRMQEEQIMIERAYWFAGEMVREKKMVLKSSAEAQEYLNSLKFKPKELVPSTMQEMDGGSKLRRPLKRPPILEQIIAGALKPKLTTLEKSKLDWATYVDKEGINEELQLFNKDGYLAKQDFLRKVDGIQNEQYKELRRQELQKNGAQGM
The following text describes a protein:
Function:
tRNA backbone modifying enzyme that mediates initiator/ elongator tRNA discrimination. This enzyme modifies exclusively the initiator tRNA in position 64 using 5'-phosphoribosyl-1'-pyrophosphate as the modification donor. Recognize the stem-loop IV region that is unique in eukaryotic cytoplasmic initiator tRNAs.
Miscellaneous:
MISCELLANEOUS: Present with 259 molecules/cell in log phase SD medium.
Sequence:
MVSRLSKRYRSRVQFSISVMDENIYLSLSQINKDIRKENKSVRNRLQSILLDNKFLQDRVIPIFPHYPLIPNERCGLWYCNPSSFKQTSYFKSTDGHVNQWDFSTRRLNFHLLETIRDNKGIIIVDSTRRGKKIPDALSKTVPIWCAVLNTLMLQETEKNVAIDKVLYLPPETVPKSEYDMIKRKIPELVAKLQKLNIIDSKKLNELFMGKLLRPIWVHPGSSLLDHSVDYFTGEVQEYEAWETPEDQNIIPIILCTVSYQAQDGMDKRYGFTYVQGAADDHELWSFGLDSNMFWAHIEYLGDASYSDDQLHDYIMDLAAAKLRNQCYIQDKGSLDEVFGNIDKITNEISLGKVSSGLTINKNLKQKLKSEYGKVIIFSNSVTVAEDTDDEEESGTDPFISIYKLQSGDKKSSKALRSTFPRIHGEIQSLFTNRDEKIKPMLICCNTGTDMSIGVILSILCTKYTEEWMLTSELPDISKLIVRKHLTKLISHLKGRNVNPSRATLNSVNSFLM
The following text describes a protein:
Function:
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKVASSSAAATAGPSCSLKAGRTAGEVVLGLSEQSVAISRCAGTRLPALLDEQQVNVLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSESEVATAGGRGLPVRAPLSTLNGEISALAAEVRSESEYYIILLWETKATGGGCPPYFSGA
The following text describes a protein:
Function:
Metallophosphoesterase that catalyzes the removal of a side-chain ethanolamine-phosphate (EtNP) from the second mannose of the GPI-anchor protein intermediate (By similarity). Participates in the glycan remodeling steps of GPI-anchor maturation to allow an efficient transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi.
Subcellular Localization:
Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Note=Also localizes to endoplasmic reticulum exit site.
Sequence:
MALVRWRLRRGNFHLLSRVLLLKLTVVIISVLLFCEYFIYHLVIFQCHWPEVKTLAHGDRQKPVLKAMFLADTHLLGEIRGHWLDKLRREWQMERAFQTALWWLQPEVIFILGDIFDEGKWSTTEAWADDVQRFRKIFRHGSHVQLKVVIGNHDIGFHYQMSKYRIKRFEKVFSSERLFSWKGVNFVMVNSVAMEGDGCSICSEAEAELREISRKLNCSREVQGSSQCEGEQRLPFSAPVLLQHYPLYRASDANCSGEDAAPPEERNVPFEEKYDVLSREASQKLLWWLQPRLVLSGHTHSACEVLHPGGVPEVSVPSFSWRNRNNPSFIMGSLTSKDYALSKCYLPFEDRVLATYGAAAVFLVVLILAHLERLPSSFLFGWKLRKMHMRG
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MASGALSASTPPNIPAPTDRLEDEFRRTLLSVNFPVEAEIVLDSQYTDLNVKFDQIEAVGDLRRTADRMTAAGYSQERVVDVYASARKSLLVEICKDLDPNVESEELKGRWTRAAKIAVHVSFPCERRLLDRIFPDLTADIAEACFVEIVGDSALCLLRFTEAITNTESPCRMFFALDLYELLSGLLPQIRTIFGSKSGESISNEAEKSLSGLSNCIITTFSENETALNREKHRIATEVNELTEEYYRDLKLYLELTWESLLDSLRSTEEVKPGVFSSFVSKKVVYRQRLKVFYDKFKKVRGTQSSWIVSDEQLRKEVRSYILSLVIPVYTSFLEKHGSDIERGDHPCICISHSVEKLRKEVEEMFQDESTISFEY
The following text describes a protein:
Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MASTRAKPTLPLLLALVTVVIPGPGDAQVSIHPREAFLPQGGSVQVNCSSSCKEDLSLGLETQWLKDELESGPNWKLFELSEIGEDSSPLCFENCGTVQSSASATITVYSFPESVELRPLPAWQQVGKDLTLRCHVDGGAPRTQLSAVLLRGEEILSRQPVGGHPKDPKEITFTVLASRGDHGANFSCRTELDLRPQGLALFSNVSEARSLRTFDLPATIPKLDTPDLLEVGTQQKLFCSLEGLFPASEARIYLELGGQMPTQESTNSSDSVSATALVEVTEEFDRTLPLRCVLELADQILETQRTLTVYNFSAPVLTLSQLEVSEGSQVTVKCEAHSGSKVVLLSGVEPRPPTPQVQFTLNASSEDHKRSFFCSAALEVAGKFLFKNQTLELHVLYGPRLDETDCLGNWTWQEGSQQTLKCQAWGNPSPKMTCRRKADGALLPIGVVKSVKQEMNGTYVCHAFSSHGNVTRNVYLTVLYHSQNNWTIIILVPVLLVIVGLVMAASYVYNRQRKIRIYKLQKAQEEAIKLKGQAPPP
The following text describes a protein:
Function:
Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.
Sequence:
MPIGAYLQYSRPASSLARAVSALARRHSVSSAPRSRPVSHAAARSRAYSIALVGTGYRGYRSHFLSLLGSPTLSITAVCDTNGTALESFSVEHPDIPTYNSLSSLLHHHRPDFAIVSVPHCAHLECISALAAKGVHVLKEKPIAESVDEYEWMTGLPVKVGITFQKRFEPHFLQFRSLLPLVGDVAAVDASLALNITNLEETWRASAGVGVTEDLGCHMLDLLVWLLGLPASVMAQQVSSVRPSQRYGGDDVCDIMMNWGTRNCIGHVRLSRVAHKPVSSIVVTGTNGTLIINGQAVTHYDTQGCETISSTHQPDEKQVIHSMVQEFGDWVTGRGPSFSTSLANVRNTVSLVDAVKMSLASRQLQRPLPLSASSTAVWGAINNRNGLSTKTLTSRVSAATLFTSTQARNRDRSFRLNTGALIPAVGLGTRRAQKPGLVYRAVRSALKTGYRHIDTAMSSGVEHEIGQAVKDSGVSRSQVWVTTKLDNRWHTRVQEALDMSLSELGMDYVDLYLMLADWDFVKTWYGKIFLSLMAGFLFLSSTGKNCKILRQPKCEILLHPYWPSRKLLQYCRNHEIHCTAYSCLGSTDSPLLEDKVLLEICKRRNKSPQQVLTDNSRIMWGLQRGTSVVPKTVNAARIEENFDLNGWALSDDELDKLNRCTTRFKSCNDDWLPATVFSEDGH
The following text describes a protein:
Function:
Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Abundant in the nucleus.
Sequence:
MAASLWMGDLEPYMDENFISRAFATMGETVMSVKIIRNRLTGIPAGYCFVEFADLATAEKCLHKINGKPLPGATPAKRFKLNYATYGKQPDNSPEYSLFVGDLTPDVDDGMLYEFFVKVYPSCRGGKVVLDQTGVSKGYGFVKFTDELEQKRALTECQGAVGLGCKPVRLSVAIPKASRVKPVEYSQMYSYSYNQYYQQYQNYYAQWGYDQNTGSYSYSYPQYGYTQSTMQTYEEVGDDALEDPAPQLDVTEANKEFMEQSEELYDALMDCHWQPLDTVSSEIPAMM
The following text describes a protein:
Function:
May play a role in carbohydrates metabolism.
Sequence:
MGFIDGSLGGSSSTLMPLHRSKTVHLVRHAQGTHNVEGEKDYKAYLSPKYFDAHLTSLGWEQVHSLRKHVQSSGLSKKLDLVIVSPLLRTIQTAVGVFGGEEYTDEIDALPLMVENAGDSDHSSISSLNCPPFISVEKCREHLGVHPCDNRRNIKEYKLLFPAIDFSLIENEDDILWTADTRETNEHVASRGVEFLNWLWTRKEKEIAIVTHSGFLYHTLQKISANYPPLIKNEISQHFANCELRSFTLMDSGALGSDSSSTNFPGGMIPK
The following text describes a protein:
Function:
Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
Sequence:
MIKYLVMNAGRLFLSLLKESGVNKIFIVSGTDYASLIEAKVEDSSLPEFEIVPHEITAISTAIGYALGNKLSAVAVHTTPGTANALGGIMSAFTSRIPLLVIAGRSPYTEKGNTASRNLRIHWTQEARDQGELVRQYVKYDFEIRMADQLPAVVSRAIQIMMSEPRGPVYIVLPREVSIQEVNEARRIPMDYYEPAPSPDKINKAKEMLEKSERPLIITWRAGRRKEWFESLRRFADNYNIPVLNYAGEVLNYPSSGPMALDRFDLRNSDLLLVVEAEVPYFPKKIDLDIPIVKIDVDPSYSYIPYYGFRCDLCIQSTPSNFFDYISIRPKSYDEIKELRAKQEEYKKQEIERLKDKKPIHPKYLSYEIGIVASEYNLVIFNEYQFNPRYARLNEFGSYFADLSVGYLGFALGAGVGYKIATNKDVLITTGDGSFIFGVPEAFYYVASKYPTMVVIYDNGGWLASAEAVDEVFPEGLAKSKKYYPGADFDRRFEIGKTVETFHGYYELVEDPWEIKPALIRGLEKMRRENKIAVIQVIVDKVR
The following text describes a protein:
Function:
Together with the serine/threonine kinase PknD, may play a role in the specific interactions with host proteins during intracellular growth. Phosphorylates IncG, an inclusion-membrane protein required for the modification of the nascent chlamydial inclusion.
Sequence:
MEERAAVEYWGDYKVIAELGHGLWSRDVLAEHRFIKKRYILKILPSELSSSENFMRVFQEVIVQLAAIRHASLVAIENVSREGDRYFVVTEENGGTISLAQYLSGRKLSEEEVVHLIQQLCDALELVHSIGLAHGQIHLHSVHVSFFNGIANIYLPEVGFASLLRERMFSTIMQSGSARESITRIRDLLMFEAPEEQEVFGREADVYSVGVLAYYLLVGSFPWGSFPKPSLCMPDSWYDWDGFILSCLQQQREVRPKCLREALRRKTSGEQLQVTLDSCREPLREMEIEDTPTELGPPSALIREGERLCEVKEEQHAFVLVEAKSIDEVMVTTVDSEEELESSEGYANPLQSLLAREPVVSRYVEVEREEIKPQPLLTEMIFIEGGEFSRGSGDGQRDELPVHNITLPGFFLDIHPVTNEQFVRFLECVGSEQDEHYNELIRLKDSRIQRRSGRLIIEPGYAKHPVVGVTWYGASSYACWIGKRLPSEAEWEVAASGGKLGLRYPTGEEIDKSKANFFSSDTTPVMSYPSSILGLYDMAGNVYEWCQDWYSYDFYESSALEPDAPLGPPQGVYRVLRGGCWKSLKDDLRCAHRHRNNPGAINSTYGFRCAKDVK
The following text describes a protein:
Function:
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
Sequence:
MSDLENIDYYDYKALLKRARSQIPDYVFQKDRFELPEIEILIEGNRTIIRNFRELAKAVNRDEEFFAKYLLKETGSAGNLEGGRLILQRRISPELLKSRINDFLREYVICRECGKPDTKIIKEGRVHLLKCMACGAIRPIRMI
The following text describes a protein:
Function:
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm.
Sequence:
MNPFWSMSTSSVRKRSEVEEKTLTGDVKTSPPRTAPKKQLPSIPKNALPITKPTSPAPAAQSTNGTHASYGPFYLEYSLLAEFTLVVKQKLPGVYVQPSYRSALMWFGVIFIQHGLYQDGVFKFTVYIPDNYPDGDCPRLVFDIPVFHPLVDPTSGELDVKRAFAKWRRNHNHIWQVLMYARRVFYKIDRASPLNPEAAVLYEKDIQLFKSKVVDSVKLCTARLFDQPKIEDLYAISFSPWNPSVHDEAGEKILTQKKKPEEQHNKSVHVAGLSWPFSKEAKTVAT
The following text describes a protein:
Function:
Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.
Sequence:
MAVDVPTSVIVKLMFFTLAMVSFPVLTFFVSQQYTSNTLVNGGLAALAANVVLFAYVIMAFSEDVPQSDGKESKKQQ
The following text describes a protein:
Function:
Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.
Subcellular Localization:
Secreted, cell wall. Cell membrane. Membrane raft. Note=Present in detergent-resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion.
Sequence:
MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAIMIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEISQDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKELGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETSSIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERNGMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGKEKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKDYGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF
The following text describes a protein:
Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. UBE2W-catalyzed ubiquitination also occurs in the presence of inactive RING/U-box type E3s, i.e. lacking the active site cysteine residues to form thioester bonds with ubiquitin, or even in the absence of E3, albeit at a slower rate.
Subcellular Localization:
Nucleus. Note=In the nucleus, colocalizes with FANCL.
Sequence:
MASMQKRLQKELLALQNDPPPGMTLNEKSVQNSITQWIVDMEGAPGTLYEGEKFQLLFKFSSRYPFDSPQVMFTGENIPVHPHVYSNGHICLSILTEDWSPALSVQSVCLSIISMLSSCKEKRRPPDNSFYVRTCNKNPKKTKWWYHDDTC
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
MAGIEITVIDYYHSKINKDSKMEIKIGELPKVLNKTYLGKLNATPSMNNPVKDTQGGEKQMESMLAYIKQKGWAGESKPNFVMNRNVIGAIPSSTGVENFIVFKTNDVQVIVKTPKEKGQESEGNQMEPWKSLIYGVNFEHHCTKTANEPLPTNDAVTKAVLKAHVPRTQEGSNNSSYSILYSAQIDGIDDKRQHYEMKVLNGGLTKYHLENSSCWFYWQSVFGNCNTLIVGSRTGKQDQDPKTLTKTRERQREELDDISYVSKFSAGKKRSSENKDTNHGSSKKSKSSSSSKTPEADNDSSKTPEADNDSSKTPEADNDSSKTPEADNDSSKTPEADNDSSKTPEADNDSSKTPEADNDSSKTLEADNDNHLRGLPELSLYRVRHLKREDIPKYKDVKWNIEDGKKRIQTFLEQVETEATENGSCYSCTIDFENKEEAWKIKKIKRKRIKGNTFLEEFTKLVHESIPS
The following text describes a protein:
Function:
Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Domain:
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Sequence:
MDRNQSRRQVAAMKQSLFDQGLLDEQFIQLEELQDDANPNFVEEIVTLHYRDSSRLISSIEQALKERNPLDFNKLDTLMHQFKGSSSSIGAKKVKTECNLFREYCRAGNAEGCMRSFQQLKREYAALRKKLEAYFQLGKLDPRKQHVAPNEDLMKICIIGQMY
The following text describes a protein:
Function:
Heavy-metal-binding protein.
Sequence:
MNKQDVMKLQTCVLKVNVHCEGCKHKVKKQLQKIEGVYSVKADVEQGRVTVTGNIDPALLVKKLSKSGKHAEILGGGGGGGGGGGKGFPNLNGQFANLNMGGNNKPKGGKESNQVKGKAGGGGGGGQNHGHGQPMQLNPQQIQQMMMMKAAHGGGGGGQMKMPPMAAKDQKKSVKFADDEDDEFSEDDYDDEDFSEDDYDDDEFDDDEDDDDEMGHGHGHGGGGGNHMPPNKMMMPNKMMPQMGGHHGNGGGPKGPNEIMMMMNGFKGGGGGGKKGGGGGFEIPVQMKGMGEGKNGKDGKKGKGGEKGKKEGKENKGGGKTGKTDAKSGGGGLLGFFKKGKSGNGDEKKSAGKKDGHGGNKVKSHGGGGGVQHYDSGPKKGGGGTKGGGHGGLDIDELMKHSKGGGGGGNKGNHNHSAKGIGGGPMGPGGPMGPGGPMGQGGPMGMMGPGGPMSMMGPGGPMGPMGGQGGSYPAVQGLPMSGGGGYYPGPPQASQQMNQQQYMQMMMNQQQQQQQQQQAVAHGGYGGGHGGDMYHPMMYARPYPAVNYAHPPPMPPPHSDSYTHMFSDENPGSCSIM
The following text describes a protein:
Function:
Derepression of silent mating type loci when overexpressed.
Miscellaneous:
MISCELLANEOUS: Present with 1910 molecules/cell in log phase SD medium.
Sequence:
MPKNRGVLDAITRSVIDGSDQESSSSFNSDKEYAAVTKGLSSSRVQKKSSLRQMKSKVKELQSLVNHYRENEAALVSSAKLLSGEIIGYEIKMASLHGKMKSILDENNALKETHKSSAEKRIELVRLPSSKEERNYDEYTLLVNLKKEICAKLQDYKNVQNTVNTKLDEIHTFHEKYYEGLELSLDSKVFDAESSKELAKVRRELNNVRKNSEIKVNNLKMQLLQATKSLEHLKKQAKAKDDYLKCIPELVDKANLTMLSYKKSIANQRETIEALQAELSQQSETKGQIETETQNQVQIPTNVTLVDPFEENNPEDLFAIQEQELQDLRLHKKMADERSRTTHLHLERKNNTIKLLQSYVQSLIQRLPPAQRKHHLGIFQKLGSEKSCPLAPAVASTYAPLLLLSQHSNHQEIDNTPQRLLLAAPDGQSYSEKSTTLNLDYSSRKSYLSRLQPPHIANLKSLTLKTLPRVPTDSPQLPSKDKSQETAKKDDRPKLVANEPVTLDTSTPPVAQSLADSKHCSGLHK
The following text describes a protein:
Function:
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKMIELCSCNGSFLVWNFEDVHRLRSEHRIVGNFIGCLPSLPRQDQMLGLPMELMIEEVYHLNSRGIVKLIEFKQLNLPAQGQNKEKIEEMHKASFADQEVIFKVERTKQLLQMADKIIEGKRRKMNGKTVDEKIALQEEIDKIPKMSKDLMMVQIFTRPHWTCQGESVLPLDFHVRPTLRCKVFSDLWEKGYYITSGEKFGGDFLVYPGDPLKFHSHFIAVCVEEHQMLTPWFLIQKGRLGTSVKKTVLMCSLDENDEVNYQSVNWNGK
The following text describes a protein:
Function:
Required for the activation of Aurora-A (aur) at the onset of mitosis.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus. In interphase cells, it is nuclear. Upon entry into mitosis, it is excluded from the nucleus and translocates into the cytoplasm in a Cdk1-dependent manner.
Sequence:
MYNDEVRTPQALKNRYITNVNGLKCRARRNSHSNSSNSSAASATPTNGGKENGKYSPQMSGNVCTPPPKRLHKVRNPFEGAMADRLHLPLIASPSLFRSRTPQLSSTQFEWNIDEVSQLKPADVEPHETQFHDSPDPEQESKAQLAISAFFKESLIVPSPVDCPLRKQRIILNCSEDNTPISNKSRRMRDCEVQTELTLPPILPKALEDALRPYFQPHLAGRLSGRSKSSGGPDIFNSSMRRKLFDLHNVIVLGEQDTAEPSRSMVGSSPQGKQTMFAGRLSDSASGESSFGCLSPIRNLCGLPPGTPDNGTCSGKRKLLMHELELPSPIAPSEHLSRRLVHSKVEISVTEQHDTLSERTALKFTPDRSSSPMGGGLEHSDCSINQRVRRLRVNSTRQVVIETGDQPLFEETEGEEEEAESEDDEEADAMQLSTVSFNCSSSNSDTPRGHKRHRSAQRKNLSQSFSANLEEEADQTQGGAGSIQPAEPPSVAMPQQGARIPLYRADSGFNETSSTTFAFSQDLPLDVSMACCSTPSTRS
The following text describes a protein:
Function:
Component of the RPD3C(L) histone deacetylase complex (HDAC). Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Controls filamentous growth and required for full virulence in a mouse model of disseminated candidiasis.
Miscellaneous:
MISCELLANEOUS: The ASH1 mRNA is transported to the daughter cell before cytokinesis where translation produces the protein to block mating-type switching, as well as to the hyphal tips during filamentous growth.
Subcellular Localization:
Nucleus. Note=Preferentially accumulates in daughter cell nuclei of budding-yeast form to the hyphal tip cells in growing filaments.
Sequence:
MSLVQSAMFNHHMGPSHTRSRSFELFQEAKTLRVAACKRSYSDDLNISTKRARTAPPSPPYETATPTRASRLVISNLVKPTSNLRSRSLSPNKKFSSPLSPSSSPIATVTSPISSPQNIKIKLPSISDALNLPPITSKEPVKLKPIVPTVSLDYFDTYKPNDENWRYGLLDKIAKESKHFHLNQYNYLNDHAKPSFDSKLSSKIQQSSIANGKKINFPYESNYTYLNKTYLNDVKNYPEYLELAAESLLQLKERQLPPPPLQSHQKQHPPPPPHLPVQGLLPVPAPPVSHFSSSYTTPQAPTFYHPPSQQQQQTPPPQTLHHQQPQPPISTHKFIPISPPSAKKSRSDLLKSPPKHHHHHAPRVCISCGSDQSPCWRPSWSIKQGQLCNSCGLRYKKTKARCLNDKCKKIPAKGEWTLMQSKGKETFEDGIEGYSCIACGWRVEVLPKS
The following text describes a protein:
Function:
Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Required for efficient export of polyadenylated RNA and spliced mRNA. The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway.
Subcellular Localization:
Nucleus speckle.
Sequence:
MSKLHARSSGQQGALALSSKNHTSHSGTKMASQYYQEMQESFRNNSKSREFPAHSAKVHSVAWSCDGRRLASGSFDKTASVFVLEKDRLVKDNNYRGHGDSVDQLCWHPNNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPDGQTIAVGNKDDVVTFIDAKTHRSRAEEQFKFEVNEISWNNDNDMFFLTNGNGCINILSYPELKPIQSINAHPSNCICIKFDPTGKYFATGSADALVSLWDVEELVCVRCFSRLDWPVRTLSFSHDGKMLASASEDHFIDIAEVETGEKLWEVQCDSPTFTVAWHPKRPLLAYACDDKEGKYDNNREAGTVKLFGLPNDS