lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MGIRLQSSDSMNNQHQTQQNKYFNVSNQASTRSLWSQQQQQQLLDTKGSASTSKSPMLMANNNVFSIGPYRQRKDAGRVSVLEKYEIIGYIAAGTYGKVYKAKAKETQEEQENSIHTHNQTLGSVSVAGIDGGMASREVENGGDDPLRLDGHGGIAVAPAAGGGLSSAAAHRARSNGAVKALPKKSAFTPFYAIKKFKTEREGVEQLHYTGISQSACREMSLCRELDNKHLTKLVEIFLERKSIYMVSEFAEHDLLQIIHFHSHPEKRLIAPRMLKSIMWQILDGVSYLHQNWILHRDLKPANIMVTVDGCVKIGDLGLARKFYNLVQTLYTGDKVVVTIWYRAPELLLGARHYSPAIDLWAVGCIFAELIGLRPIFKGEEAKMDSKKSVPFQGNQLQRILEVLGTPTHHTWPNIHKYPEYEQLSKFSKYRDNLSVWYHSSGGRDKAALSLLYSLLKYDPITRIDAIDALEHEYFTNNDPPVSSDVFEGLSYKYPPRRIHTSDNDIMNVGANKNKSGFNHHPPQQQTVNNNGVTNSSIGGLGVNRRILAAAAAAAAAVQVNGTNIVSGSSSSNGPIRKKKR
The following text describes a protein:
Function:
Transfers a CMP moiety from CTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin cytosine dinucleotide (Mo-MCD) cofactor. Is specific for CTP; other nucleotides such as ATP and GTP cannot be utilized. Is also able to convert MPT to MCD in the absence of molybdate, however, with only one catalytic turnover.
Domain:
The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein. When the N-terminal domain of MobA is fused to the C-terminal domain of MocA, comparable kinetic constants as wild-type MobA are obtained with GTP, and the activity with CTP is completely lost. Consistent results are obtained when the N-terminal domain of MocA is fused to the C-terminal domain of MobA: the kinetic constants with CTP are comparable with the ones found for wild-type MocA, although no activity with GTP is detected.
Sequence:
MSAIDCIITAAGLSSRMGQWKMMLPWEQGTILDTSIKNALQFCSRIILVTGYRGNELHERYANQSNITIIHNPDYAQGLLTSVKAAVPAVQTEHCFLTHGDMPTLTIDIFRKIWSLRNDGAILPLHNGIPGHPILVSKPCLMQAIQRPNVTNMRQALLMGDHYSVEIENAEIILDIDTPDDFITAKERYTEI
The following text describes a protein:
Function:
The glycine cleavage system catalyzes the degradation of glycine.
Subcellular Localization:
Mitochondrion.
Sequence:
MTAPGRVGRLGHIVGPSTMAFRGAMPARLPLRASTTISCPQPLVAASCLRLASSESSQRGKLMKIIPSTAWVQYPELFPVREDFASRHIGPDNSSIQEMLGVLDPPVESLDQFVQEVIPADILSKRELFPQTRVRFHATKKYPTRQGHQEWEIMKIAESMASSNRHSVKAQIGAGYYGTLTPEVIKRNVLESPAWYTSYTPYQPEISQGRLESLLNFQTMVTDLTGLPIANASLLDEGTAAAEAMTMSLNALPASRAKRPAKTYVLSNRLHPQTRAVLRGRAEGFGVNIITLDFHDPEFPSKLEELGDDLVGVMVQYPDTTGQVLDHRQLADLVHKQGALLSVATDLLALTMLTPPGEWGADIAFGNSQRFGVPLGFGGPHAAFFAVQEKHKRKMPGRLIGVSKDRLGGRALRLSLQTREQHIRREKATSNVCTAQALLANISSFYAVYHGPEGLRAIAERCNLGARVLESAAKFCGLQLYSPNNSCSAVPFDTLVINQDHIGKVLVYAARERGINIRFISTDSAGISVDETTTENDLISLIGAFQDAARSLKVTGRDEALDANPQVIFEHFLKHHAEQIKQSGPLGHLPEPLRRTSSYLTHPVFNTHHSETELLRYIHHLQSKDLSLVHSMIPLGSCTMKLNASAEMALITLPGFSNLHPFVPPDQSEGYSRLTKVLESQLIDITGMDACSLQPNSGAQGEFAGLRVIRKYLQSRAQSQRDICLIPVSAHGTNPASASMAGMRVVPIKCDTKTGNLDLADLEAKCKQYENELAAMMITYPSTFGVFEPAIKKVCQIVHAHGGQVYMDGANMNAQVGLCSPGEIGADVCHLNLHKTFCIPHGGGGPGVGPICVKEHLAGFLPTTKTMSNTELNLPVSSASYGSASILPISWAYNALMGGAGLKKATQVTLLNANYLLSRLKEHYPILYTNEHGRCAHEFIIDARPFEKTSGIQAIDIAKRLQDYGFHAPTMSWPVANTLMIEPTESESKEELDRFVDALIAIREEIREVEEGKQPREGNVLKMSPHPISDIIGGDGEAGNKWDRPYSREKAAYPLPWLREKKFWPSVARVNDTYGDLNLFCTCPPVEDTTGGNQSSIQEQ
The following text describes a protein:
Function:
Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.
Sequence:
MGKHRTAQQDAIFVAFMERHPIISKNYLKGDKQAAEAAWKRLSNELNSVGPPVKEASEWKRVWKDWKSCIRKKITNNRLENSKATGKGSLYQDTLTPLEDAVAVICDLYDMADTIAEGCPKDQTEMAHGVSLKFIKTDQDDSRVKDNQYYKDEDCSINIRRFGGQLEHSANTSQTTSKKRKRFKETALEIEQERSVPVLLGIARELSDLNRQSRLNAQRTKANTEALLALSTQIADLMQQQLKERKRLNAIIEKFVLKMESSD
The following text describes a protein:
Function:
Notch pathway component, may contribute to the specificity between lateral and inductive Notch signaling pathways in the wing disk. Required during many developmental stages including oogenesis, embryogenesis and imaginal development of the eye, wing and leg. Ebi and sno regulate EGFR-dependent Delta transcription in the developing eye, by antagonizing a repressor function of Suppressor of Hairless (Su(H)). They are required in the R-cells for normal cone cell development.
Subcellular Localization:
Nucleus.
Sequence:
MTSKKRKTLLDADDDNDNFDEDDSGSDFDDDEDPDQIEVPGGGRDLNTAVTYAQNIRSGVGVAPKGGIPIPISGAKIVVGNNKIKPISLLRINNNNNNIVTSVNNRNNNNIISTNGSSNNNNNSINNNSQIIKTTTVTTTPTTVGATPTVGGVALGGKLTVIPIAGRNVALDNNLSNMPKKLNNMVTAMGSPAARSSGNAGTTGSSQGGAIGSTSSYLNSLTTNELMNLAAYVAAKGSNAPPPPPPSTAANSVRHSPTGGIPNPGGNFFGGSAAASTSASAANFNMAASLLAQMSYAGGASQIRALKVAGNIGGVGNNQKPPPIATTPGSGGPAGGAPGSGVKGNNSMMEAVQKLIAMNPEYLTSGIPNTVFQMFMQSMQRPQATPSPNQPMNPGAMVTSAAAAAAHASAVAYVQQEEDEVDYEEMGVAETYADYWPAKLKLGKKHPDAVVETASLSSVEPCDVYYKLSLPLETINSGHLSALQLESITYASQAHDHLLPDGSRAGFLIGDGAGVGKGRTIAGIIYENYLKGRKKALWISVSNDLKYDAERDLSDIGATRIEVHALNKFKYAKISSDVNNNCKRGVIFSTYSALIGESNNKTGKYRSRFRQLLQWCGEDFEGLIIFDECHKAKNLCPVGSGKPTKTGQTVLELQQKLPKARVVYASATGASEPKNMAYMVRLGLWGQGTAFGNFNDFITAVERRGVGAMEIVAMDMKLRGMYIARQLSFKGVSFKIEEVPLSKEFRKIYDQSVELWVEAMQKFTEAAELIDAESRMKKTMWGQFWSSHQRFFKYLCIAAKVNHAVLVARESIKYGKCVVIGLQSTGEARTLDQLERDDGELTDFVSTAKGVFQSFVERHFPAPDRNRINRILGLYDETPSLSSVADSTSSLSNNSNITTAAGKRKGSNNNDNRSTKIKKKKRSGSWECSDSEDENTDMKRNRKRDGGNSNSDSDEANSDDDLKSDIDDEDEDHDVDSDQRSVASDASSDFNPFFSGSDSDIDPWVNARSKKSKKAQKKSKKKVKKEKTKKEITTSSATDPSGSTAMSATVVAALNAVKNRKSQLSTQDKIQDLLQKKQELKGTVTPVGVNGVKLNYGPPPKDAIERACTMKEELLRKIERLGARLPPNTLDQLIDELGGPDNVAEMTGRRGRVVQTDDGSIQYESRTESDVPLETLNITEKQRFMDGEKDVAIISEAASSGISLQSDRRVFNQRRRVHITLELPWSADRAIQQFGRTHRSNQVNAPEYIFLISDLAGERRFASTVAKRLESLGALTHGDRRATETRDLSQFNIDNKYGRQALETVMRTIMGYESPLVPPPTDYSGEFFKDIAGALVGVGIIVNSESHPGVLSLDKDYNNISKFLNRILGCPVDLQNRLFKYFTDTMTAIIQQAKRGGRFDLGILDLGAAGENVTRVRLIRFVRKHATGVAPTEMHTVRVERGMIWQEAIDKYADLFNENEGFYLSHQLRNQKRTAIMVVILESRNSSSTSSTTDLDSGSKKKKTHSKKEIMCQIYRPNTGLQVRHESLFELEKKYRKVASEEAEPHWTEQYDASVNTCSHAYWNGNCRNVSLGNDCEVGLRQRLYHVLAGSVLSVWGRVEHILNTRSNSKMQVIRMKTTEGEKIVGTLIPKSCFEPLVADLRSDSEKQEEFNY
The following text describes a protein:
Function:
Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3', transcription regulation may be tissue-specific. Regulates the expression of target genes such as: IGF2, PGAP6/TMEM8, ENHO, and PIANP. Acts as a transcriptional repressor of growth factor IGF2, thereby negatively regulating postnatal growth of muscles and internal organs, especially in females. Negatively regulates myoblast differentiation and myoblast mitochondrial activity via its regulation of IGF2 transcription. Negatively regulates the cell cycle of myoblasts, potentially via transcriptional regulation of the E2F family of transcription factors such as: E2F1 and E2F2. Positively regulates the cell cycle and survival of pancreatic beta cells. Binds to the CDH2 gene and may directly repress CDH2 transcription. Probably by controlling CDH2 expression, regulates pancreatic beta cell adhesion, and formation of cell-to-cell junctions between pancreatic beta cells and neural crest stem cells. May also play a role in embryonic beta cell differentiation. May play a role in insulin sensitivity and glucose clearance.
Miscellaneous:
MISCELLANEOUS: Encoded by an exapted DNA transposon located in an intron of the Zc3h11a gene.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Cytoplasm. Note=Located predominantly in the nucleolus but is also dispersed throughout the nucleus. Mainly cytoplasmic in insulin- and glucagon-positive islet pancreatic cells, however nuclear localization is evidence in some pancreatic endocrine cells.
Sequence:
MSVCTLSVPVSSISPGRRCSTFGDAGILGCVSINSNTDEDDVVEGKMVAEGANKETKLPAKKKRKKGLRIKGKRRRKKLILAKKFSKDLGSGRPVADAPASLASGAPEQDEESLFEGNIEKQIYLPSTRAKTSIVWHFFHVDPQYTWRAICNLCEKSVSRGKPGSHLGTSTLQRHLQARHSPHWTRANKFGVTNGEEDFTLDLSLSPPSPGSNGSFEYIPTDSVDENRMGKKRDKSASDALRAKRGRFLIKSNIVKHALIPGTRAKTSAVWNFFYTDPQHISRAVCNICKRSVSRGRPGSHLGTSTLQRHLQATHPIHWAVANKDSGAIGNGLDETETESSDLLNDTMPGEKSSGSQDLTAEDLSDSDTDEPPCLEVENRSESPIPVADQDNPVHAQERETTTHCENAAANQISQAVIQMIVEDLHPYNYFSTPAFQRFLQIVAPDYRLPSETYFFTKAVPQLYDSVREKIFLTLENVQSQKIHLTADIWTHDPSTDYFIVTVHWVSLETASSPSNGGTPNFRKWAVLCVTGLAKDCLITNILQELNDQIGLWLSPNFLTPSFIVSDNSSNVVHAIKGGGFTHVPCFLHCLNIVIQDFFCEHKSIENMLVAARKTCHHFSHSVKARQILQEFQNDHQLPWKNLKQDETGHWISTFYMLKWLLEHCYSVHHSLGRASGVVLTSLQWTLMTYVCDILKPFEEATQRVSVKTTGLNQVLPLIHHLLFSLQRLREDFQVRGITQALNLVDSLSLKLESDALLSAMLKSKHCILATLLDPCFKNSLEDFFPQGADLETYKQILAEEVCNYMESSPGACQISSSETSGPLVRLGTDSFTSIKEGTSSAGSLDSSAAGSVAVGSKSSLLPAAVAVVDEYFKEKYSELSGGDDPLVYWQRKVSIWPALTQVAIQYLSCPMCSWQSECMFTTNSHFHPKQIMNMDFDNIEQLIFLKMNLENVNYDYSTLILSWDPENKAVQSNEKEILP
The following text describes a protein:
Function:
Prion-like protein required for the formation of Balbiani body (electron-dense aggregates in the oocyte) and germ plasm assembly, and for the establishment of oocyte polarity during early oogenesis. Mobility and aggregation properties are improved by tudor domain-containing protein tdrd6 through interaction with dimethylated arginines Tri-RG domains. Establishes oocyte polarity through interactions with RNA-binding proteins rbpms2 and dazl, initiating a positive feedback loop amplification mechanism in the Balbiani body. Interaction of BUC protein and mRNA with rbpms2 and dazl is required to mediate Balbiani body formation. Involved in recruitment of germ plasm to embryonic cleavage furrows and dorsoventral patterning through interaction with Kinesin-1/KIF5BA.
Subcellular Localization:
Cytoplasm. Cleavage furrow. Note=Localizes to nuage (a peri-nuclear protein-RNA aggregate that associates closely with mitochondria), the Balbiani body during oogenesis, and in the germ plasm upon fertilization. Accumulates at embryonic cleavage furrows.
Domain:
The dimethylated RG motifs (RG[X0-4]RG[X0-4]RG) motif mediates interaction with TDRD6 and is required for Balbiani body formation.
Sequence:
MEGINNNSQPMGVGQPHHPVNHTRPFFYVQPPSQPYFMYQWPMNPYGHYGFPGPALHFGRPYMAPYQFMQYPGYVIPHAPMQPIDYRRINPHYPSVASYDLRVRHHFQNAGMHRETACSEVQTDPSDSVNKLIDKIESLKACELGSDKGPNNVVSSTPDVVQGEKLTRLNEDSNLEVATKECKEDPVTRPTTYSDSAYDAESSQGRLDECVFSDVLPLDSSSVHEEEEEEEKDVNEEDEPQTVADEICSQNEMSASTTSNVFCSGVQSIADPTECHDLEKLGDEQKQDIPSADAAAVIEPLISLSEDFDLPYQILRLPCNKTTTGLSLEREIDPLVYFDSPSTLLPPQNYLSSIGSAYSYSYYPQVTQERQSVLSPSIDELSSRDEMFSTDVEDLEVVPGHVYVGGGRLAEASDMPVRSRKELPSVDKTCSVCQKTCACCGSTLQDEVGMCKMAEHSHPERDEMSDQDCDYDLEAEVRSNCESPRVSKRKCCSRHALPSCGHHCAKHRHRKLLCEGQESCDLREQARVHPKGECCEEYGALAKADKRIQKGALCRPCIEQQWREGVVSDQENWASCGAKPRSWRQVTGPQDQGRTPLRRSTCKSIHQQRPRSEYNDYDETEFTYCQRGRGSMKKRGSRY
The following text describes a protein:
Function:
Mediates influx of magnesium ions. Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The central ion permeation pathway is formed by the first transmembrane domain from each of the five subunits. Mg(2+) binding strengthens interactions between subunits and leads to the formation of a symmetrical homopentamer surrounding a closed ion permeation pathway. Low cytoplasmic Mg(2+) concentrations trigger both a conformation change within each subunit and a loosening of the interactions between subunits. This results in an open ion conduction pathway. In addition, this results in a less symmetrical shape of the whole complex.
Sequence:
MITVIAIAKDGSIVEPKLDEISFEDYRLIWIDCYDPKDEELYKLSKKIGISVSDLQIGLDEQEIPRVEEDEDFYLIIYKAPLFEEDITTTSLGIYIKNNLLLTIHSDKIKAIGRLHKLISTKKPRIVFERGIGFLLYHILNEITRSYSRILMNLEDELEELEDKLLAGYDREVMEKILGLRKTLVYFHKSLIANRDVLVLLKRKYLPITTKEDRENFEDLYYDTLQLIDMSATYREVLTSMMDITLSLENIKMNQIMKILTMVTTIFAVPMWITGIYGMNFSYLPLANNPQGFWLVMALMVVIIMIFVYIFRRSGWI
The following text describes a protein:
Function:
Putative oxidoreductase that negatively regulates the retrieval of cargo from late endosomes to the Golgi.
Subcellular Localization:
Cytoplasm. Membrane; Single-pass membrane protein.
Sequence:
MSNSRNIVIVGGGITGVSCLYFLAHHPSFNRDRDTITLFESAGIASAASGKASGFLSLEWHGPSTSSLAALSYNLHKELSDQYDGVNKWGYRALDTWSIKADENCQQPDKLPEGIEWIAPSIVENVTRLGNKKNSGQVHPYKFCHAIYEEASKVANVTLVKGHVLSVDENEVEYRLIGDDYAPDEEEEITSAEELHTIHSMEATHIIVAAGPWTPQLIPNLRISGARIHSITIDLPIKLNGNAVFSEITYKDGTIAAPEFYAREDELYVCGEFDDEPLPELSSDTKVDQDKCALIKQCANHFHQIIRDSPVKVRQACYLPISNATGAPVIGKIGSSIYVAAAHGCWGITLGPGTGKVLSELILDGAVTSANIDLLDPEGSLE
The following text describes a protein:
Function:
Plays a role in the biosynthesis of B-band O antigen for serotype O5. Catalyzes the C-6 dehydrogenation of UDP-D-GlcNAc to UDP-N-acetylglucosaminuronic acid (UDP-D-GlcNAcA).
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MIDVNTVVEKFKSRQALIGIVGLGYVGLPLMLRYNAIGFDVLGIDIDDVKVDKLNAGQCYIEHIPQAKIAKARASGFEATTDFSRVSECDALILCVPTPLNKYREPDMSFVINTTDALKPYLRVGQVVSLESTTYPGTTEEELLPRVQEGGLVVGRDIYLVYSPEREDPGNPNFETRTIPKVIGGHTPQCLEVGIALYEQAIDRVVPVSSTKAAEMTKLLENIHRAVNIGLVNEMKIVADRMGIDIFEVVDAAATKPFGFTPYYPGPGLGGHCIPIDPFYLTWKAREYGLHTRFIELSGEVNQAMPEYVLGKLMDGLNEAGRALKGSRVLVLGIAYKKNVDDMRESPSVEIMELIEAKGGMVAYSDPHVPVFPKMREHHFELSSEPLTAENLARFDAVVLATDHDKFDYELIKAEAKLVVDSRGKYRSPAAHIIKA
The following text describes a protein:
Function:
Cell wall formation.
Subcellular Localization:
Cytoplasm.
Sequence:
MLNCGYCCERCIPFIIIGNVSNCLFDDFGFEGCVILNRIDFLERIKPDVYRVGSGYRFNRLGVQCTNEGFSGLEFASGIPGTVGEAAYMNAGANGQETVDAIDIVEIVTVDGRHQILYRSDLAFGYRVSPFQAMQDLAAIVDVTFRLLPSASAKERQQAYLRKKRWSQPMREQATGSVFRNPPGMGVSAGELIQKAGLKSFRVGSAEVSKVHANFIITAAQIPERCLNSLAWLKQELKRNLEYNSESLPTQL
The following text describes a protein:
Function:
Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MQTPLQHSQSSSQFPNGGAAPVKRRNYRVLYDPEIHYKAAYAKKPIYRFDGHAKPPIQAVDPREHNPNYSRGIPNSSRPVRKSLLPVQFEYDSNSIGPEPPTQVLITNLSPLVTANDIRYHFKTFGSVNEVDLQLNPYNGTSLGLCRVTFRKDPSVSAAHAAAKKAVASGTGLRLNGKCMRVELDKDGSLCRKAYERAVHALEEQLAAEEAHQQELAQAEAVAKAKAAALQAQAAAAASRQNQKVHRYGSYEPSYFTESPSHSHSYAPSSSSSSSALPSSSHSSHHPPENLDELVYLFIDDRFVPPDRVLYSDIRHHFRKYYYDRIYMDRRGFYITFSNYEEARECYYRLDRTYVNDCRIKLRFHEPPVLRNHVPEKDITTTTPRERVLKAATDAILTELSEVLLRDIKTKIAGPAIFKFFTDYKNAHPRSDKQEAAIEARVEPASIDAKSTKLEEEVPVDVPLDSLLHKKTVLPKFRKRVTSGTTTKGSKALPTAQSVRRRRRRHSDARPLYHRLNDNVDDSEYSEGKEDEDVSDTHYTQNILSETSSSEEEVEEGDQLILNTHDHETEEEEESEDNEDFLEKFHAASQKSKTTEEEQPDFTDEIDYTSSDEETVQEQAVAPLPEHTEVSESALKAERVETKIEATTVTIKSTISESIVPAIPVKQNTWSEDGFVFHGTLPNTYPEDEVLLDLDGFQQIVKDDEDLQYLREVVAAEESKELGDTNYWAYRRKESKIRNGDAEPSNLVLPFNKNEYHKPNSTGSARTEGYYMVPAAEKSQYLPLRNRVSLEKANTSSSRITSRMNRVNNRRLAAGVEKSNLNSETDLLRFNALKARKKQLRFGPSRIHTLGLFAMENIDKNDMVIEYVGEIVRQRVADTRERKYVREGIGDSYLFRIDKDAIVDATKKGNIARFINHSCAPNCIAKIIRVEGHQKIVIYADRDIEEGEELTYDYKFPEEVDKIPCLCGAPTCRGYLN
The following text describes a protein:
Function:
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
Sequence:
MHVSELQTLHISKLLELAEEHGIENANRFRKQDLVFAIVRQMMKKGEGFTCSGTLEILPDGFGFLRSADTSYLAGPDDIYVSPTQIRRFNLHTGDTIEGSVRVPKDNERYFALVRLDTINGDHPEVCRHKILFENLTPLFPTEQLKLERDLKSEENLTGRAIDLISPIGKGQRALLVAPPKSGKTVMLQNIAHAVTANYPEVELIVLLIDERPEEVTEMSRSVRGEVVSSTFDEPAQRHVQVAEMVLEKAKRMVEHKKDVVILLDSITRLARAYNTVVPTSGKILTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALVETGSRMDDVIYEEFKGTGNMELHLDRRMAEKRLFPAININKSGTRREELLVPNDQLQRMWLLRKFLHPMDEIEAAEFLIGKIKASKNNDDFFELMRGK
The following text describes a protein:
Function:
Plays an important role in the degradation of dermatan and keratan sulfates.
Sequence:
MIPRLWDLLILLLTTSLANCLLHVQKNEIRTFDSLDGLWTFVREPHNGGDIGIGNQWNTLDLDKFPNATVMPVPSAYNDIGTGSELRDHIGWVWYEKKEFVPLRDRNMRHVLRFASVNYFAVVYVNSEKVTSHTGGHLPFEVDVSSQIKFGAENKFTVAVNNTLSWSTIPQGDFNYQKLAQRNISGRIVSPMLSRLPDGAVKNVGNFDFFNYAGILRTVQLVKIPSIHIQNINIVADHTGSFFFETAANNLDGIQVEVKMFDGDSNQVFTTNQTKTEGKLENAKLWWPRGMGDPNLYTLEVSLISDGELVDIYRETFGFRTVTWSDSQIFINSKPFYCLGFGMHEDFELIGRGFNQAVMTKDLNLLEWMGGNCYRTTHYPYSEERMFENDRRGIAVIVETPAVGLKGFSKANNNLHIKMLTDMIDRDKNHPSVFAWSLANEPVTSKKESRAYFKTLVDTAHGIDRTRPVTTVYGPTNFDNDETADLMDFICVNRYYGWYIDMGYIPWINQSVYWDISLWRETFHKPIIVTEYGADSIPGLNQEPSVDFSEQYQNEVIQETHHAFDALHKDHTITGEMIWNFADFMTGMRFPTTRAVGNHKGVFTRSRQAKIAAYTLRNRYLKRFDQTQLEIWD
The following text describes a protein:
Function:
Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass type IV membrane protein. Peroxisome.
Sequence:
MASALLGSGDPTRPTYDVDFSEAINQRMQVPVRLKVAGGPDLEDPQETGGDLPPSFHMHIPDRISLAEATEGSLRPFFRQNSDSMSPAVPVDVSGRLTTLVRAGTAVSRRVVPPAPTGRLQRERAPGEDSRLLLRRAQSGRDRPKRGSSPAPVCPPIMQGNRIFCLQNVFQTVWFLGSLLSHRLQASLMPQAQPSSQDPGPVLEASLEDMGGSEIMAMKKQLYKISRRLQSLEEQCTGWKQKELLLYSMLVSACVINTWLWMRR
The following text describes a protein:
Function:
IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation.
Sequence:
MTTRYRVEYALKTHRRDQFIEWIKALLAVPFVLYSQPHGVLEDPDRSVDTLSQTREEAHRRYSEIFRDIEAMIDDHIAHQNDAENPFPSKLKLLVPSIGPFFTRLPLEAAFKFQDNKRYISSRRFVSPSFNDIRLILNSAQIMAVTTYGTLQLATFDGDVTLYDDGQSLEPTSPVIPRLLDLLRKNVKIGIVTAAGYTTADRYYSRLHGLLDAMANSADLTPSQKQSLVVMGGEANYLFEFDSSSPHLLAPVPRQHWLTPEMAAWNEQDIAQLLDVAEAALRDCIKTLNLPATLMRKDRAVGIIPVSPEIRIPRESLEETVLLVQKILELSTVGRSRRVPFCAFNGGRDVFVDIGDKSWGVTVCQRWFSQKEGPHGVIKGENTLHVGDQFLSAGANDFRARSVGTTAWIASPVETVELLDELAELMGKKMS
The following text describes a protein:
Function:
Electrogenic antiporter that exchanges one cholinergic neurotransmitter, acetylcholine or choline, with two intravesicular protons across the membrane of synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to store neurotransmitters inside the vesicles prior to their release via exocytosis (By similarity). Determines cholinergic vesicular quantal size at presynaptic nerve terminals in developing neuro-muscular junctions with an impact on motor neuron differentiation and innervation pattern (By similarity). Part of forebrain cholinergic system, regulates hippocampal synapse transmissions that underlie spatial memory formation. Can transport serotonin.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein.
Sequence:
MEPTAPTGQARAAATKLSEAVGAALQEPQRQRRLVLVIVCVALLLDNMLYMVIVPIVPDYIAHMRGGSESPTLISEVWEPTLPPPTLANASAYLANTSASPTAAGSARSILRPRYPTESEDVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATFFAARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGVSSCVVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLLRNVGLLTRSRSERDVLLDEPPQGLYDAVRLREVQGKDGGEPCSPPGPFDGCEDDYNYYSRS
The following text describes a protein:
Function:
Involved in plastid rRNA processing and consequently in translation and early chloroplast differentiation. Involved in organellar RNA editing. Required for the processing of multiple editing sites in plastids.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MALPLSGTRHLTRALLSNVTLMAPPRIPSSVHYGGSRLGCSTRFFSIRCGANRSGSTYSPLNSGSNFSDRPPTEMAPLFPGCDYEHWLIVMDKPGGEGATKQQMIDCYIQTLAKVVGSEEEAKKRIYNVSCERYLGFGCEIDEETSTKLEGLPGVLFVLPDSYVDPENKDYGAELFVNGEIVQRSPERQRRVEPQPQRAQDRPRYNDRTRYSRRRENTR
The following text describes a protein:
Function:
Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAQSRDTGNPFPDSGELDNPFQDPAVIQHRPSQQYATLDVYNPFENREPPPAYEPPAPAPAPLPPPSAPSVQSSRKLSPTEPRNYGSYSTQASAAAATAELLKKQEELNRKAEELDRRERELQHVALGGAGTRQNNWPPLPSFCPVKPCFFQDISMEIPQEFQKTVSTMYYLWMCSTLALLLNFFACLARFCVDTGSGSGFGLSMLWLLLFTPCSFVCWYRPMYKAFRSDSSFNFFVFFFIFFVQDVFFVLQAIGIPGWGFSGWVTALVVVGSKPAVAVLMLLVALLFTGIAVLGIVMLKRIHSLYRQTGASFQKAQQEFAAGVFSNPAVRTAAANAAAGAAENAFRAP
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). As one of the FG repeat nucleoporins NUP1 is involved in interactions with and guidance of nuclear transport receptors such as SRP1-KAP95 (importin alpha and beta) through the NPC. Like the closely related NUP2 it also plays an important role in disassembling and recycling SRP1-KAP95 to the cytoplasm after nuclear import. Upon entry of the heterotrimeric SRP1-KAP95-cargo complex in the nucleus, NUP1 binds through its C-terminus to KAP95, thus accelerating the release of KAP95 and, indirectly, of the nuclear localization signal (NLS)-containing cargo from the SRP1-KAP95-cargo complex.
Miscellaneous:
MISCELLANEOUS: Present with 468 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side.
Domain:
Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side: FXFG repeats are especially abundant in NUPs on the nucleoplasmic side (in a highly charged environment and enriched in Ser and Thr).
Sequence:
MSSNTSSVMSSPRVEKRSFSSTLKSFFTNPNKKRPSSKKVFSSNLSYANHLEESDVEDTLHVNKRKRVSGTSQHSDSLTQNNNNAPIIIYGTENTERPPLLPILPIQRLRLLREKQRVRNMRELGLIQSTEFPSITSSVILGSQSKSDEGGSYLCTSSTPSPIKNGSCTRQLAGKSGEDTNVGLPILKSLKNRSNRKRFHSQSKGTVWSANFEYDLSEYDAIQKKDNKDKEGNAGGDQKTSENRNNIKSSISNGNLATGPNLTSEIEDLRADINSNRLSNPQKNLLLKGPASTVAKTAPIQESFVPNSERSGTPTLKKNIEPKKDKESIVLPTVGFDFIKDNETPSKKTSPKATSSAGAVFKSSVEMGKTDKSTKTAEAPTLSFNFSQKANKTKAVDNTVPSTTLFNFGGKSDTVTSASQPFKFGKTSEKSENHTESDAPPKSTAPIFSFGKQEENGDEGDDENEPKRKRRLPVSEDTNTKPLFDFGKTGDQKETKKGESEKDASGKPSFVFGASDKQAEGTPLFTFGKKADVTSNIDSSAQFTFGKAATAKETHTKPSETPATIVKKPTFTFGQSTSENKISEGSAKPTFSFSKSEEERKSSPISNEAAKPSFSFPGKPVDVQAPTDDKTLKPTFSFTEPAQKDSSVVSEPKKPSFTFASSKTSQPKPLFSFGKSDAAKEPPGSNTSFSFTKPPANETDKRPTPPSFTFGGSTTNNTTTTSTKPSFSFGAPESMKSTASTAAANTEKLSNGFSFTKFNHNKEKSNSPTSFFDGSASSTPIPVLGKPTDATGNTTSKSAFSFGTANTNGTNASANSTSFSFNAPATGNGTTTTSNTSGTNIAGTFNVGKPDQSIASGNTNGAGSAFGFSSSGTAATGAASNQSSFNFGNNGAGGLNPFTSATSSTNANAGLFNKPPSTNAQNVNVPSAFNFTGNNSTPGGGSVFNMNGNTNANTVFAGSNNQPHQSQTPSFNTNSSFTPSTVPNINFSGLNGGITNTATNALRPSDIFGANAASGSNSNVTNPSSIFGGAGGVPTTSFGQPQSAPNQMGMGTNNGMSMGGGVMANRKIARMRHSKR