lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Sequence:
MEEDTLEACLDLPSGDYEYKFKMGKTWFCDTTKPVVPNVFGTLNNYIEVVKETDGGSATSFPETVQVTHLDPEILQQALAKVSEETQTSEVEIEKTDERSTAGGDDKNSTTFVEEQTPIQEDKVSEEKETSKDGVEKTDESTIAECVRISATCVEEKTIQENKVSEEKEAPEDKIETTDESGIAEKDDKISPTCSEEQTIQEDTEPTATVAPQQFVIQDSLMSICMTPDMPPPVISKQATHEDKDFSEETVSQGRKRDEPTVCVCRKPVPIPVRPVPQETTSNDVIESESEAITETASQDETAAEGSEDTSQKSNETAQQHEEVVKEEQPELTMETRVENFDQTAVSVVERLEEKDDIKTTAQETTQMVETITPDVEKESKERVTPDSVEKEEDNTVPEAIMIKDTTGKGVAFVEKEAKPDERAEDEETVSREGKTDEPVICICYKPTPVTLVLSPETTSEDAIEPKSVATTDTTSPDKTVGDIAEGTDKKPDETAQQQEVKVVEEQPESSVDEEDGKPVEQAADDNVQKVESVEVSMETPLRDEEVEIIDEKREEVVQDIKEKPDQKVSNEETPQNEATERPDLDVSDKSEEKTSSQTTHPDQAADEDVIDIVVQSVDETVVKAAPAAGETFEENIHTEVTLPDETIKTTVPCTVAAPEEIDETNVWPPQEITIQEAVTNLETAVITESPTQDKDDTAADFVAATDELAASEIQRRVTDSVQEVSPQIAEKVEDQDATATKKDEESSEIPQSEGTTHDTVLVTSEDVYEKGHSEISPTKEPVEVIVLDTVEKLDDTTQTETPPALPTGVADTAEKVTSKTAPTFEPTQKDAPDIAEEVKVITVKITKEPQTGKPFKAAALQSKTYAQAVKDSFPKVEKTVQENGDMSDVGETHKETPPKDKSVDETVPENVELPKEEVTEMLPSEKVEEKVSEKEELTKEEIHIDAPSEDIIIKTIVEPQSVEFGEEKVHTETPPPDKPVERVVSEKTEEPKMEIHTETPPEDKTPENTVQQQQVEVVEEEKEEVQVVVQEKVQTETLSPDKTVETKVSEKMEGLEEEVSIETPPEDKTVKETVKPQVSEVVEETIQTEAPDKPVDEKVSEKVEEAKEEIHTEAPPEDKIIMTTVQPQNVEVVKETIHTETPPPDKPVDEKVSEKVEVPKEEIHTETPPEDKTVETTVQTHKVEVSEDTVHTKTQPPDKPVEKVSETVEVTKEEVHIEASTENDKPVEKIVQPQQVSEVSERQVHTETTQPDKPVDDKVSEKVEIPKEEIHTETPPEDKTVETTVQTQEVEVSEDTVHTETSPPKKTVEIIVSEKKKVVKEEVHTETPLEDRSVKETVQPQKVKVVEDKVQPETPPSDKPVEIIVSEKTEVVKEEVHTETPPEDKTVEKTIQHITVEVSKEESHTETPPTDKPVEKKVLEKVEVPKEKLHIEAKSTVEETAPHIVECYKTIHEILTETEPTDKTVEIKVSDKVEVPTEKLHTEAESIVEKTAPPKVEPCYKTIHEILMEDTTEKIPLFEYTQFTLVCKEETSGDVFVQGSWDGWKESFKLNKSEDGSYSESVMLPYGLHEYKYRVGNSWIHDDTKAAVRNAFGTINNVLRVPAEAGGKDSLEIPPEEDSDLEECMRVRLDWTGEATGDVFVSGSWDGWTRSWKLKRR
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MDLFPPKFSKVLVTPDPQYIPGYAGYCPQLKYHVGQTYGQLTAKLLTSPEVSHSQRLVLQTSPLSSTEKETASRSQIWWSRHGASRNLETMIPGYTGFVPLRQNYICKTYAETCRDALSEFNQGQAKRLHNASADLSFPVINSVPDFRPRRSNSPLIALSKDPAPYKAPDPWKPPGSPYFMEDSSPHKYFISGFTGYVPKARFLFGTGYPTITNKALIQFSKEMKAGPASLQKYSLQEEDSSNLPLIPTIYPSKTGLLPSYTGHIPGYRFQYGHTFGKLTHNALGHTASQKNAGAIRLS
The following text describes a protein:
Function:
Required for 60S ribosomal subunit synthesis.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MADRTGLGSGDITGYTLFERIESEEIGIELDDVQKAVVELPRFQKIVRLKSFAPFRSAAHALENAMDISEGVMSDHLKAFLEMNLPKPGKKNKVLLGVGESNLGGSIKADLGIDCVVDDTVRELIRGIKLHSERLLAQLKEGDLGRAQLGLGHAYSRAKVKFNVNRVDNMITQSINLLDQLDKDVNTFSMRVREWYGWHFPELVKIVSDNFLYAKLVKVIRNKGDLSEDKLDALEAVTNDPIKAKQILDAARASMGTDISEIDMVNIQSFADRVISLTEYRKSLYGYLLSKMHAVAPNVSALIGEIVGARLIAHAGSLTNLAKYPASTVQILGAEKALFRALKTRGNTPKYGLIYHSTFIGRAAQKNKGRISRVLANKVSIASRIDCFLDNPTSKFGEFLRDQVEERLRFYEEGVTPRKNADVMADALKAAGIDMDIDEEEEEAPEVASTPAKKRKSSKESKEKTPTAKKSKKEDAEVFESPVKEKKSKKKEKASVEETVVEPKSAEKKKAKKAKQ
The following text describes a protein:
Function:
Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids. Neutral amino acids are the preferred substrates, especially methionine and phenylalanine.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
ILFASFTSAQKDEGQTDDSRTQWGQGLQFFLSCLSISIGLGNVWRFPTLAYQNGGGAFLIPYFVVLFLIGKPMYFLELAIGQFVGKSPLKIWKCVPGFRGIGIAQIFSTFYTLVSYNYIMALCLFYMFASMQSVLPWTYCDTEWSDETCYDNDLVRAPGRGLEKTNLFLNISSFRKYVLKNSGGFTLPSALDWRMALCLLLAWVCEALSTIKGVDSIGKVSLGVLQDLLNVTFVNLFFTCLQDGAFTGIKAFFVPQWEKILDIEVWFKACEQSFFSLGIGFGYLVMYSSFNDFKHNVGRDAFLISIADTITSVLAGCVVFGTLGSLAHELGTDDISQVLKGESDLGLAFVTYPEALSRISFIPQFWSVMFFIMLFMLGLGSGVGGVQLVTTVLTDQYPGWTKWKSHISILFCVISFGTGLVLCTD
The following text describes a protein:
Function:
Involved in endocytosis.
Subcellular Localization:
Cytoplasm. Note=Found at the cell tip and the barrier septum.
Sequence:
MFSAKAKTYELKLEQTRCNGDWQAIPEVARKLHKHNSSKSFVCELAKIEASLKSALTAELKNIANVLEPKLIDNQYSLIPALPSARTDPLLSQLNSLNIQNATEDEKLQETSIRLLLYIVQRKFPEAVDLDWSPQGIPWTETSTGICILQATVLSSLAQYAQANDEVAYQYVRSAIGLIQNANIGKKPLPELTRWCDLAYSLYAQMSVSACSSQLERANILTTCLSYFTEHKSVNLLYKLVTSRQAIKYLEHILRTNTNGSKIFTKSPVKNLYLNWPQLVLDYGSLLCNFTSFPKAGDQNMFAVEFIELATSIWINTEKSYDITVSLIRMLYQLTGKCFQAQQIFRSLVFFLRHIEEFEEASEAFEIYKFLCVKSHERLARKNSDVAGSFSDIKPVFVDEPKSIIEVCSVMMTVYAQYLRNLKKVSEILDYITKIASDYDLLKRDDIAPLIYHTEGVAYSFMYYQANNPSLRERYHQKSVQSYQKCLEKQPTNTNALFHLAMQYSERRAITDAMQIVRRLLEVNPKYSIVSWHLLVLCVSCSEQYAAGIKLIDSVFETWGINHVNEDGTIEISLTNLTFNDRCALVDLLITKLALFEAEKGVEATLDIQDEIFTLFASIFDLNEYRISKEGSSDELSTLLERSTIQSIKSSKKISKDVENEKGSILGFSRKSSLKRSTVLSKKSHSSYKENFQLRRGKTVSYLNQKLWLTAASLFLKSGNDDQARSALLEAKKIDHECAWVYYLNGLSLLQQGKEVEGYEQLDVAHYLDPEDPLISTALAKCLLQGGYGPMHSRRNRADAILSSCTLQYGWDLPEAWYYTAEIFRQLGDLKQAAFSYDYCIQLADTNPVRRWSNLQPRFMNV
The following text describes a protein:
Function:
Transcription factor that behaves as a negative regulator of adhesion. Recognizes specifically the canonical CSL response element GTGA/GGAA. May also play a cbf12-antagonistic role in the regulation of a number of other important processes such as extracellular material production, colony morphogenesis, ploidy maintenance, or meiosis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGDYFAWDFANISGSNTSGSLNLNQLNLDNINNGLHNQEDGAGGRNENSERVGSGSPGSVSMQVLSLFSAVNSALATLEKSEEFPSVVKDEQSIFPAVAKASNSLDELAQNIIPAPSPPGFNRKRKTFDEDSSVEMIRRAISDHLDLLNNCCIGIANLNEDSVHKISLTRSGKPSQLVTVSCRHSSVIQKSYGSEKRYLCPPPMVYINGNYSSIFNQSFRTEISIMNDFGQCSQPISEEYTGQGCMIFRSLHISSLVAAKSKNLRLSLDMFSNVNNQLLSHLVTSSISIVSKPSKKGSKLKISNITLRSGSVVSLYNRINSQTVRTKYTSIEAGQFCLRGDRWVPLRINLLLPDENGKLKVCDDVDNPEPIKYGSIVELVDEATGTTSDPLIIRRVEKDHIAEEDGYVNQMHRIVLESAYPISNVRHLKIAEHSSLAYSNNISVRWFLGATSAQNRNASSEAILPIEWEAVGNLSSNEMTRVGDSVCWTIVGISHFDCTMMLPFNQNPVPTVTDYPYIEEPPEYLESSRSLQFKIGGYSVGLQIWLGVHGPLSYSFTAAADTSTMGTVTLGLSQISYDPSCAEQKYPLLFVIPGGIVIIGKCEILLTSSAFGN
The following text describes a protein:
Function:
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
Sequence:
MTKSELIERLCAEQTHLSAKEVEDAVKDILEHMASTLESGDRIEIRGFGSFSLHYREPRVGRNPKTGDKVELEGKYVPHFKPGKELRERVNLGS
The following text describes a protein:
Function:
Involved in the second cycle of side chain dehydrogenation in the beta-oxidation of cholesterol catabolism. It contributes partly to the virulence by increasing the efficiency of beta-oxidation. Catalyzes the dehydrogenation of the five-carbon steroid side chain of 3-oxo-chol-4-en-24-oyl-CoA (3-OCO-CoA) to yield 3-oxochol-4,22-dien-24-oyl-CoA. Can also use 3beta-hydroxy-chol-5-ene-24-oyl-CoA, and shows weak activity with cholyl-CoA and deoxycholyl-CoA.
Domain:
Contains two ACAD domains separated by a short linker. The two domains interact to form a single active site.
Sequence:
MVATVTDEQSAARELVRGWARTAASGAAATAAVRDMEYGFEEGNADAWRPVFAGLAGLGLFGVAVPEDCGGAGGSIEDLCAMVDEAARALVPGPVATTAVATLVVSDPKLRSALASGERFAGVAIDGGVQVDPKTSTASGTVGRVLGGAPGGVVLLPADGNWLLVDTACDEVVVEPLRATDFSLPLARMVLTSAPVTVLEVSGERVEDLAATVLAAEAAGVARWTLDTAVAYAKVREQFGKPIGSFQAVKHLCAQMLCRAEQADVAAADAARAAADSDGTQLSIAAAVAASIGIDAAKANAKDCIQVLGGIGCTWEHDAHLYLRRAHGIGGFLGGSGRWLRRVTALTQAGVRRRLGVDLAEVAGLRPEIAAAVAEVAALPEEKRQVALADTGLLAPHWPAPYGRGASPAEQLLIDQELAAAKVERPDLVIGWWAAPTILEHGTPEQIERFVPATMRGEFLWCQLFSEPGAGSDLASLRTKAVRADGGWLLTGQKVWTSAAHKARWGVCLARTDPDAPKHKGITYFLVDMTTPGIEIRPLREITGDSLFNEVFLDNVFVPDEMVVGAVNDGWRLARTTLANERVAMATGTALGNPMEELLKVLGDMELDVAQQDRLGRLILLAQAGALLDRRIAELAVGGQDPGAQSSVRKLIGVRYRQALAEYLMEVSDGGGLVENRAVYDFLNTRCLTIAGGTEQILLTVAAERLLGLPR
The following text describes a protein:
Function:
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (By similarity). Inhibits daf-21/Hsp90 ATPase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MPIDYSKWKDIEVSDDEDDTHPNIDTPSLFRWRHQARLERMAEKKMEQEKIDKEKGTTSKKMEELEKKLAAADVTDKSDIQKQIDEVKAQEEAWRKKEAELEEKERLEPWNVDTIGHEAFSTSRINKITEKKPQAPKTDEEDTHAMSTFFETHESLLEKMAVLKNGAKSTELFLAEHPHMASEYTANWLTIEALNAAIDFNEEKMKTMAEQCIIIQYLLELSKSLNAVATNTTVQKQFFKKFEAAEPVYMKHYQDEVKAFEDRLRTRAQTKRDAAMEEAEAEEKAERMKSAPGGIDPQEVFEQLPEEMRKCFEAHDIEALKGVAQKMDEEVFKYHFDRCIASGLWVPGKADDDDDDEEAAPAEEEPTTSS
The following text describes a protein:
Function:
Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEDTSNDAVESSTSNNEITFAAIRRWERQRQLRRLEATTIMKRRRRASPISSNMMTKISKQRSMKHILEQHFFLKHPLNDELRFFHDNLSMPLLIEGLEQHVLQLPNMSNYNSSLPLEEDPTRELPKSVVIMYCEGCQSYSYTGRSVWHKFDPNSLTLLRFLLRRVSFHIRKLQLWLISAHFMEHDNGFDSTVRVALNLQYEAADGSRHTKISTVRYNLGYLKCPSCSDLIDETQLSSVLQLRLYSCSNQILDLLHLRVLQKRPTFFNIKKIKHTDNGMDFFFDSEHGARKLNYFLKVEAPVKTDPIIENIVSTDTMIDNTAICQSCIRVTVCPISRDDLVYLPKKVFAALGIEYMGPLVICTKVSRNITFIDPLKLNECWINSNNYWRDPFEPLKVSQELVEYIVLDIEIVLSGPLNSLGKARVARVSDFGKNDTSFMVETHLGNTLKAGDYALGYDLVGAVVMNCEDMLPDVVLIKKKYVALAKLRHSVPQKNASPDYEKFLVDLEKNPAAMFNLSLEDGDDAQKHDLDDLLARLDLTD
The following text describes a protein:
Function:
May glycosylate diterpenes or flavonols in leaves.
Sequence:
MRHQKVTHVQKDFCLLVKEDYISTLNIIIVIDILFLELNVIIVIDVLLLLLAGAFSSSFIHTLWRTIEQAIAKNGDGDENFLLAFQEIPNLPEFPWWQVPQVMRDYETGDQEFESFRKGMLANMTSWGILYNTFEKLEEVYINHMKSIMGHDRVWAVGPLLPETNGPIAITGRGGWSTVSPDHLFTWLDEKPNESVVYICFGSQVELNEKQMSALARALELSKVNFILCVKGSESSTIWTIPSGFEDRVGNRGLIVMGWVPQLAMLTHRAVGSFVTHCGWNSTLEAIIGGVVMLTWPMIADQFANAALLVDQLGIAKRACDGGPESVPDSVELARLLDESLSVERPERVKIKELNQEATNAVEQGTSTRDLDTFVKLVSEI
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
Miscellaneous:
MISCELLANEOUS: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
Subcellular Localization:
Nucleus.
Sequence:
MANNMNFVRVVANHNSQPSRHIYIKAPVTMAQTVRGADAAGNQNQNAGKGGVETTQLVGGQRPGAARKANRMLLGLLEDSARYDMKSDYSLPDTWLRKRRATAQKTAKAEDKSVDTKKTRAAGKKTKPSEAGPDAKARSGMTSAPSSSSTDAAAPAATGKARNGKARAASSVTRNTVLANASPFASPSEDVIELQHQFFRITDHQDCVNREITSSLLLTPKDVADQQIVRLHFILYPDVSEEYKVTFGHPNNGVFNPIHEIGKCIKYAVEIYFPKTFKKKGSKLLQQLSKAYASMNQSAFVEAVEQYNDLVRAIPQDQVNEHLQQTKKIPRAFIHDILQMAYSRCVLPNVNGLKEYRSFSNFVYGELLPTFLSTVYQQCDLKPGQIFIDLGSGVGNCVVQASLEYGCALSFGCEIMKNASALAKSQLKELEERCALWGVDLKPIEFSLRKSFIDNERVNELLPQCDVLLINNFIFDTKLNQAVEKLIQGLKPGCKIITLKNLRPSGYTINFDDVENILNRLKVEKFTLPEDSVSWTYRGGGEYFISTVQADIDESVFHSYAKGRVRGMRPAKYTK
The following text describes a protein:
Function:
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MTLYYSLVFLLLMMEIIVFLVLIIPLPRRLRKSVFNFCASSPFIGKVQYSMKITFIFIIVLFIDSVSRVMKVTEEYNYARVSAHPESMRSEVQARKFYAQRNMYLCGFTLFLSLILNRHYVALSKLFTTQDRVDALTKRLEQSEATASKPSEQEKTLREKLDAVTNDYELLSEKYAKMQKATEPKKDI
The following text describes a protein:
Function:
EsxH, in complex with EsxG, disrupts ESCRT function and impairs host phagosome maturation, thereby promoting intracellular bacterial growth. The complex acts by interacting, via EsxH, with the host hepatocyte growth factor-regulated tyrosine kinase substrate (HGS/HRS), a component of the ESCRT machinery.
Miscellaneous:
MISCELLANEOUS: To improve expression in E.coli the proteins were cloned as a single protein in the order esxH-esxG with a cleavable thrombin tag.
Subcellular Localization:
Secreted. Note=Secreted via the ESX-3 / type VII secretion system (T7SS).
Sequence:
MSQIMYNYPAMLGHAGDMAGYAGTLQSLGAEIAVEQAALQSAWQGDTGITYQAWQAQWNQAMEDLVRAYHAMSSTHEANTMAMMARDTAEAAKWGG
The following text describes a protein:
Function:
Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs. Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation.
Sequence:
MAEGEAEGESRSEGGHDGGSGAAATGAGSPERGVAAIKPQYLTTKEQFHTFLETKGKDAEGQGTEKPTGRDAEEEEPICQGLPEPTTKKIKLEDEKEETQGQGAEEVEQQQKRRARGQNKNRPHVKPTHYSENKLCPSVIQASADKCFFGERCRFLHNLASYMATKPPDLGDRCVLFDTFGKCIYGVTCRFAGAHLGERQQNLVDEERAAQWRDRQLVRNSLSKELQQQLRKKKVLFSRSERYLRQLNKPSAGKGRTPDPGGPAPAEEAPSLKLEGQEPQPGGLEEEPRAGGGASPSGTVQTSGPLTDEDVIRLRPAEKKELDIRGKLYLAPLTTCGNLPFRRICKRFGADVTCGEMAVCTNLLQGQSSEWALLKRHHSEDLFGVQLEGAFPDTMTKCAELLNQTVEVDFVDINVGCPIDLVYKKGGGCALMNRSNKFEQIVRGMNSVLDVPLTVKIRTGVQEKANLAHRLLPELRAWGVSLVTVSRRQGGRGERIVSLGSSHLQGRALPPGFFHRPLGSRPQLPSASRPKLMEFCPSPSGSSPRLLGSCPSPSGSFPRLMGSCSNPSGSSPRLAGSCPQPLRSLH
The following text describes a protein:
Function:
May be involved in neurite outgrowth.
Sequence:
MGTVPDPLRSAKLSLVTLSEEKNGLGELSPKYQQKEATIERNSNGYPFGAKVQPTEEQLFGVNCVAEANVQKTEQSCGYDTSSPTMLSPGSFNRSKEGCLETVNNSKQEASSDCKGQVLVESHSLGQAALKAPAIQETNQVGGELLFSAVDDKASSPSKEGDCVMKNKTHETSSLLPSHPDTSPTTPAVKQIVEEKFAPEKNGSPTSAKELEPVSGLELKSPVCMDAKPKGVKDESSHPSARTVPESLSKSKSENKSQPSLKGETIEEAVPEPSKFRDTGTMTVPATRENISRTCQDAEVQAVASMESKSASTSPSIFAAFLKESMPSEAKQKQDQLHIIYTAAGGKEQSEIVDNFTQKAPSTGIMPEVHIQAPAATKKKLVAQVVKTQDDPSGMMNAVCSASLDKAEHPCPLASGCTQEISVKEMEVQTPGVARYYSGLPQQMADSSVLQKTRPVYQISIHTSNQPLAPSQPVNIETTLPPCSGLPEVKSKHHHIGISVTENQPTSPSCGRQPEEDKVLPTTAGPHSTRTGEQLQIKTISDVDIKPKKEDSFVHPDSKEQKTSKRAAVAVAVVGLQATCPPIAAQKERGNFSATQKETGAIGLESEWSSNSAPDQETKTSERRKDPKLSRTEAPASIQPAASHGGKKKEAKSEAKVHLKQSKHVRDVVWDEQGMTWEVYGASLDPESLGIAIQNHLQRQIREHEKLLKAQNTQTRKSISSDTSSNKKLKGRQHNVFQSMMQNIRRPNCCVRPAASAVSD
The following text describes a protein:
Function:
Catalyzes the glucosylation at the O-5 position of anthocyanidin 3-glucosides to form anthocyanidin 3,5-di-O-glucosides using UDP-glucose as sugar donor. Anthocyanidin 3,5-di-O-glucosides are molecules that are responsible for pigmentation. Involved in biosynsthesis of accumulate gentiodelphin, a unique polyacylated delphinidin-type anthocyanin, in the petals. Also acts on anthocyanidin 3-O-(6-O-malonylglucoside). Much less active with hydroxycinnamoylglucose derivatives. No activity in the absence of the 3-O-glucoside group.
Sequence:
MVGRGKGKGREHVLLVVFPAQGHISPALQLAFKIVAHSSIDLTFLTSSSAVASILIGLPPTAPALNFAAFSQGNLHNDDDDDDDAKDYMHTLCKHGSQSVRDIIHSTKKGQGQGQGQGQGQGQGQGHPITRILYTTLLPWAADVAREFRLPSVLLWTQPVTTFLTFHYYFTGYEDAINKVRNQQGTEDDSTIQLPRLPLLSSRDLHSFMLPSNPFKGAINTFKEHLEALDAEETPPTILVNSYDALEEEALQAMIPKYKTMGIGPLIPSSVFDTRETTCEVVSLVPDLAQKSKDDCQWHGWLNSKAEGSVIYVSFGSHVKQSKAQTEEIAKGLLASGHPFLWVITSNEEEEGDEIMEQNLVEEIQEKGMMIVPWCAQFQVLKHPSVGCFMTHCGWNSTLESIACGVPMIGFPKMFDQPTISKLIAHVWKVGVRVNAAVDGIVGQEVIKNCIESVMDPDGIGRELNENVRKFMSLGKKAAEEGGSSHNNFKAFLQDMTGGTTTIN
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSRRVEFDLSTEDHSDRRRTNTFSSSADEDGVPNEVADYLVYFSRMVDEQNVPEILTLYDQAFPDLTERFFRDRMWPDENVVERIIGPGNKLFIILYKELYYRQLYARNTRGPLLVHRYESFMNYQELFSELLSSKDPIPLSLPNVWLWDIIDEFVYQFQAFCLYKANPGKRNADEVEDLINIEENQNAWNIYPVLNILYSLLSKSQIVEQLKALKEKRNPDSVADEFGQSDLYFKLGYFALIGLLRTHVLLGDYHQALKTVQYVDIDPKGIYNTVPTCLVTLHYFVGFSHLMMRNYGEATKMFVNCLLYIQRTKSVQNQQPSKKNFQYDVIGKTWDQLFHLLAICLAIQPQRIDESIASQLSERCGERMMHMANGNIDEFRNAFATGCPKFLSPTTVVYEGVNQSKEPLLRQTQSFLEGIESQMALPVLRGYLKLYTTLPTKKLASFMDVDDEHYDSFIGKLLTYKMIVNELGKEAGPSSADDDEPQTDIDFYVDRDMINIADTKVARHVGEHFIRHIQKLQEVQDVLKRLDIQKP
The following text describes a protein:
Function:
Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Constitutes the pore-forming subunit of the MAC complex: during MAC assembly, C9 associates with the C5b8 intermediate complex, and polymerizes to complete the pore.
Subcellular Localization:
Secreted. Target cell membrane; Multi-pass membrane protein.
Sequence:
MSVDRRFALLIWLLEIILLVNGTKISLSETALNRPRREIETPAPIDCKLTSWSEWSSCEPCQKEMYRSRTIEAFGQFGGKRCLHSLGDRRSCEPFRACDDEEYDCENDFKCETGRCIKKRLLCNVDNDCGDFSDEDNCEKDPRSPCHTDVEMSELGRTAGYGMNILGMDPLDTPFDNEYFHGLCERVRDGNTGTYYRKPWNVATLNYDTKAEKRLRTENYEEHVLQITDTFRERQKNFGFDISLKLTSTEGPLSSLNAAASFDSNVPEFGEAEARAPESTIAKEEAPEDRILKEAPKDGTPGEAPEDRILKEAPKDGTPGEAPEGGTPKRKPDPKRNQQDAGLTFRFRYSKNESLHLIKYYASDKTKMFLQVKGEIQLGRFHMRNREFMLKSTFLDDLKALPTSYEKGEYFGFLETYGTHYSSSGNIGGKYELIYVLDKEEMQRKGLEIQDVRKCLGLDLDLSYQSAVNFEANIKGSDCSSVNWKRFDDNERKHIIDDVISLIEGGTREYATNLKEKLLRGPKVVDVTDFLNWSASLDNAPVLINQKLLPIGNLVPVRMENAHEKKQNLEQAINDYVDQFNSHKCQPCQNEGTTMLLDGECICACKTGFQGVACQISPVV
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MPSASRPLYNFLFRKNYVFLGAVFASAFGFEMAYDSITDRVWDSINKGRQWKDIRSRYVEAADDE
The following text describes a protein:
Function:
Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Enriched in the cortical ER. Concentrated in punctae along the ER tubules.
Sequence:
MNGHFAAVDNGNGSSPDSNAHSFEHGIQVINEDKQYNTNLNEYLNETHVAEAGFNYHLISVFGSQSTGKSTLLNHLFGTQFSVMSERERRQTTKGIWMSKNKNEGKMADNILVMDVEGTDGRERGEDQDFERKSALFALATSEVLIVNIWEHQVGLYQGANMGLLKTVFEVNMQLFLKDKQNQTRSLLFFVIRDHIGVTPLANLRNTLIQDLTHIWSSISKPAGLENSKIEDYFDFAFAALPHKILQPDKFISEVQNLGSRFIAGHRNKDSDATDDQELTGGVFLPEYHRRIPADGLSIYAEGIWDQIVSNKDLDLPTQQELLAQFRCDEIAREVQIAFDAAIAPLEEQQAESTRAGKPAVLPNLGQIGAEAREKCVKNFETQASRYHKGVYTTKRAELEDKIDNRLKALYQAHLTAAHKAGVTAFSEAVANAVKAGQKAGGAYEFAEIVEKQKTKTLEIFKKEAQSLAIPGVAWSNFKPQYLIFEKELDEVSARLRKEEMRRLAIRVERWVKSRLGDAIGLEFNKLGSGRGGSGAPESGEKPATEKDIWDRVWKAFISIVGEAESRFTDRAKSFEASDDEVQVGLWRLRRKSWVALREKIEEEVMESNILMKLRENFEDKFRYDEDGVPRIWRPSDDIEGIYTRARESTLGLVPLLSRFRLTSTSAPPDLIEFVGPQPHGVEPGDEEDLTPIGGVDEDEGKSLEEETTILSEPKKQDLVVRFKKMADGVYVEAKRSAIGGITQVPLYFYAVLLVLGWNEFVMVLRNPILFLLLLLISGGTYVAYSLNLLGPMMQMANAASTQGMEIGKAKLRDFLENHEGARGALGMPPKNAQRVESGISMDTLDSNGKRKETGLGAEDDI
The following text describes a protein:
Function:
May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNRLPDDYDPYAVEEPSDEEPALSSSEDEVDVLLHGTPDQKRKLIRECLTGESESSSEDEFEKEMEAELNSTMKTMEDKLSSLGTGSSSGNGKVATAPTRYYDDIYFDSDSEDEDRAVQVTKKKKKKQHKIPTNDELLYDPEKDNRDQAWVDAQRRGYHGLGPQRSRQQQPVPNSDAVLNCPACMTTLCLDCQRHESYKTQYRAMFVMNCSINKEEVLRYKASENRKKRRVHKKMRSNREDAAEKAETDVEEIYHPVMCTECSTEVAVYDKDEVFHFFNVLASHS
The following text describes a protein:
Function:
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).
Sequence:
MAAPGFCRTLFSYTWFLVSWTFQVIFLRILGVISPAKQRQILVKVAKATQFWDSQLQFDDYADTFLSFTAYLDVCWAVWHDVTSAVRVGSRAPLCDVIELETGTSRHLLEFENAGRPLVLNCGSCSUPPFLAKLADFKRLAADFEQTADFLTVYLAEAHPPSGWALKNNIDIPQHRSLQERLAAARKLQRYDDHTPCPIVVDTMDNAVAKTYACYPDRLFVILDGRVAYRGGLGPEGYHLDEVRHWLRNFSGIARKE
The following text describes a protein:
Function:
Largest component and core scaffold of the TFIID basal transcription factor complex.
Subcellular Localization:
Nucleus.
Sequence:
MGDGERREDENPTTSAADDDDDEDYDEPGGGNHFLGFMFGNVDDSGDLDADYLDEDAKEHLFALADKLGPSLKDIDLIKPSAAPTDPSEQDYDAKAEDAVDYEDIDEEYDGPEVEAATEEDHLLSKKDYFSSNAVYASVNSKVSVFDEENYDEDEEPPNDNDLPSDNIVQNCTSASAEQLDMAPSNDNLAVEKMSSSLSEPEESFESEAFQKEMVAEEQLESKTATSLPVLCIEDGSVILKFSEIFGAQEPVRKAKMDRHKRPVNKELQITNFTDIVEEDEEVFLRSTIQNLSALKHIKTNDNFVESDSDESTSDVALRLKDSCLSEQPMKDKDIPTAVQSPVFPDFYPLEHENWENDIVWGNSPTTAIQPCLTSCAISKESLDDHNEDQAEGYVSGCWDVQNKFHSSSVMADPFGHTEIPDSTSYRSPENSYSPLRKETAQENNSLDEPNNITQPVKIDTTRHLNKLSLLNKELLEGSWLDNIVWDPSEDVPKPKLIFDLKDDHMLFEILDEKNGDHLRSHARAMIVTRPMKTSAVENVDHNNQAIALSGRFNISNDKFYSNRKMSQQARSHAKKRATMGLKLVHSVPAQKLQTMKPKLSIKEIANFHRPKAKWYPHENKLTARFQGDECSHGPMTAIVMTLGGKGVKFLVNAEETPLSVKSKASKKLEFKPSEKIKLFCSGKELQDDISLAMQNVRPNSILHVVRTEIHLWPKAQRLPGENKPLRPPGAFRKKSDLSVKDGHVFLMEYCEERPLLLANAGMAARLCTYYQKTSPSDQTATSLRSNSDGLGTMLAIDPADKSPFLGNIRSGSHQSCLETNMYRAPVFPHKVATTDYLLVRSPKGMLSLRRIDKLYAVGQQEPHMEVFSPGTKNMQNYILNRILVYVYREFRAREKPGIIPQIRADELPIQPPITEAIVRKRLKHCADLRKGPKGHLFYIQRPDFRIPSEEELRRLLTPENVCCYESMQAGQYRLKHLGIEKLTQPVGLASAMNQLPDEAIELAAAAHIERELQITSWNLTSNFVACTNQDKENIERLEITGVGDPSGRGLGFSYVRVTPKAPVSNSTHKKKSAAAKGTTVTGTDADLRRLSMDAARELLLKFGVPEEQIDKLTRWHRIAMVRKLSSEQAASGVTMDEIPVSKFARGQRMSFLQLQQQTKEKCQEIWDRQIQSLSAMDGNENGSDTEANSDLDSFAGDLENLLDAEEFDDEDVGNTDIRSDKMDGMRGLKMRRCHTQSQINEEIQDDVAEAALVEKLLEESDSDMKRKKQPVETTNYSTPMYNQGNKMKQGKAGQMIKSSVYAGALTPKESIPREAKEVENFAEGSLPSKLRTKTGFDANDDIILVKRKNIPGKDGFKEKRQGARGDTLVCGACGQLGHMRTNKLCPKYGEDPETSEMDVNSIRSHPPDIVSNAQIKTSNKRLVAKVSSEAFETEGPESIEKAKPVPVKFKCGAPEKSLDRNMSISASLVSDKRMMDATDSKSTGKVNKIKISNKIKYDDYPPDTPKPSVVIRPPAEVEKDLPRKKIIIKQPKVLGDQQRPTELRSGQEPRKTRKIVELSSFEKRDREDDNGFSGQPIQINSSHDRGWGLVGKRSKGIMESSESWRAFEEQRERQEQRLIEARIYDARREDELQKAKKKNKKKKKHEFRDDDLLDPRPYKNDRRVPERGRAAKRRTPADMTEYTPPAKRHRGGEVELSNILEKIVDHLRTMSCSFLFRKPVTKKEAPDYFDIIERPMDLGTIRDKVRKMEYKNREDFRHDVAQIALNAHTYNLNRHPHIPPLADELLELCDYLLEESADVLDDAEYAIED
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MKREEKKEIEKEKEEKEESSNDEDEEDDYFTVSNKFNKTSKNIIKPLDPKTLHSVLSTLPDTHPEEKTKLIESYYKTQDSIINYPFNKMYNDLKLNYSLLINGVGDKSKVLKKFVDNFCVDGPAIFFKGYLPTLSIRDLLFRITFSIFGMDKGFGSPITHCNFIKSIFESNSIDKLKFLGGKYSYIPENLYIVVLNIDGPSLRNTTSQTALALLSSIPQIHLIATIETYSPTLLWDSNLFEQFYWVKHTLTTYLPYKKELTYQKSLINQNQKGSSSLDPDGVLTVLQSLTPNTTNIFTELLEHLIKKKIKKIEFKELFEICKEGFLVSSELGLKNQLREFLDHKIIVKKIIGDTEYLLVPLEFSTMQIILDKLVSFEEKE
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MAAASRSASDTAEGWRDGGSIDDEGAEVELSLRLRTGSSSSAARRSMTIFYNGRVCAVDVTELQAREIITMASQQILTEQQDSSGGGTAVAQCGAHQNPSQSAPQRWASRPLRQGAVTSQAAAAGLSMKRSLQQFLQKRKTRVAAMGSPYAGGRRAVPS