lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acyltransferase required to remodel newly synthesized phospholipid cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL), a key component of the mitochondrial inner membrane, with tissue specific acyl chains necessary for adequate mitochondrial function (By similarity). Its role in cellular physiology is to improve mitochondrial performance (By similarity). CL is critical for the coassembly of lipids and proteins in mitochondrial membranes, for instance, remodeling of the acyl groups of CL in the mitochondrial inner membrane affects the assembly and stability of respiratory chain complex IV and its supercomplex forms (By similarity). Catalyzes the transacylation between phospholipids and lysophospholipids, with the highest rate being between phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) and CL. Catalyzes both 1-acyl-sn-glycero-3-phosphocholine (lysophosphatidylcholine or LPC) reacylation and PC-CL transacylation, that means, it exchanges acyl groups between CL and PC by a combination of forward and reverse transacylations. Also catalyzes transacylations between other phospholipids such as phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) and CL, between PC and PE, and between PC and phosphatidate (1,2-diacyl-sn-glycero-3-phosphate or PA), although at lower rate. Not regiospecific, it transfers acyl groups into any of the sn-1 and sn-2 positions of the monolysocardiolipin (MLCL), which is an important prerequisite for uniformity and symmetry in CL acyl distribution. Cannot transacylate dilysocardiolipin (DLCL), thus, the role of MLCL is limited to that of an acyl acceptor. CoA-independent, it can reshuffle molecular species within a single phospholipid class. Redistributes fatty acids between MLCL, CL, and other lipids, which prolongs the half-life of CL. Its action is completely reversible, which allows for cyclic changes, such as fission and fusion or bending and flattening of the membrane. Hence, by contributing to the flexibility of the lipid composition, it plays an important role in the dynamics of mitochondria membranes (By similarity).
Miscellaneous:
MISCELLANEOUS: The enzyme was named after a masochistic character Tafazzi, once popular on Italian television, apparently due to the difficulty encountered for its identification and characterization.
Subcellular Localization:
Mitochondrion outer membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Domain:
The HXXXXD motif is essential for acyltransferase activity.
Sequence:
MDSNNSNNNNKNLKQICDIPKPQFLSKGVFTLVGVLCKFWISMNTVTTSGIDKLVNEIDKTHQLKRPMITIANHSSNLDDPLLWGVLPNRILMDPSKQRWTLGASNILFTNWFYSKFFSLGKCIKIVRGDGIYQDGMNESIDRLSEGQWLHIFPEGRISQQTQLLYFKWGLGRLVGECYRRTGVVPLVVPIYHQGMEKSMPLAKLPIPRVGINLDIKVGDNIYCDQVISKYIDDNKISDLTDYLSQDDKKRKDFYKTITLHIEDEYQKIIPPTNRGRFSHPTIKD
The following text describes a protein:
Function:
Hydrolyzes trehalose-6-phosphate to glucose and glucose 6-phosphate. Can also very effectively hydrolyze p-nitrophenyl-alpha-D-glucopyranoside, but it does not recognize trehalose, sucrose, maltose, isomaltose, or maltodextrins.
Subcellular Localization:
Cytoplasm.
Sequence:
MTHLPHWWQNGVIYQIYPKSFQDTTGSGTGDLRGVIQHLDYLHKLGVDAIWLTPFYVSPQVDNGYDVANYTAIDPTYGTLDDFDELVTQAKSRGIRIILDMVFNHTSTQHAWFREALNKESPYRQFYIWRDGEPETPPNNWRSKFGGSAWRWHAESEQYYLHLFAPEQADLNWENPAVRAELKKVCEFWADRGVDGLRLDVVNLISKDPRFPEDLDGDGRRFYTDGPRAHEFLHEMNRDVFTPRGLMTVGEMSSTSLEHCQRYAALTGSELSMTFNFHHLKVDYPGGEKWTLAKPDFVALKTLFRHWQQGMHNVAWNALFWCNHDQPRIVSRFGDEGEYRVPAAKMLAMVLHGMQGTPYIYQGEEIGMTNPHFTRITDYRDVESLNMFAELRNDGRDADELLAILASKSRDNSRTPMQWSNGDNAGFTAGEPWIGLGDNYQQINVEAALADDSSVFYTYQKLIALRKQEAILTWGNYQDLLPNSPVLWCYRREWKGQTLLVIANLSREIQPWQAGQMRGNWQLVMHNYEEASPQPCAMNLRPFEAVWWLQK
The following text describes a protein:
Function:
May assemble to form large pore channels with gating and ion conductance likely regulated by membrane lipids.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDAFQGILKFFLNQKTVIGYSFMALLTVGSERLFSVVAFKCPCSTENMTYGLVFLFAPAWVLLILGFFLNNRSWRLFTGCCVNPRKIFPRGHSCRFFYVLGQITLSSLVAPVMWLSVALLNGTFYECAMSGTRSSGLLELICKGKPKECWEELHKVSCGKTSMLPTVNEELKLSLQAQSQILGWCLICSASFFSLLTTCYARCRSKVSYLQLSFWKTYAQKEKEQLENTFLDYANKLSERNLKCFFENKRPDPFPMPTFAAWEAASELHSFHQSQQHYSTLHRVVDNGLQLSPEDDETTMVLVGTAHNM
The following text describes a protein:
Function:
Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLLEVIPLTLPLLLTLLPIVVILVMLLVFRKAADVSGIIGWLAISVVAWLGFQTAPEVILRSTAAGFIRSFSVSLIVATSLLQMALMEKTGALRRITIFIRTIASDNRAVQIMMINIGFGTLMVAVGATPVSILPPILLAMGYSTYVAIALPAIGYDSLCTYALLGAPIVVFVDIANSFLGKGNEIALHQAGMVFYMFLPVVSTMIGFCMLWIVGKWQAIRDGWLPCLLTGAVIGVVARFTNQYDNLVVLTGVLCGIAVIAAMAAYLVVTGGKVIDRSLLSAEEREFAAAMPLWRAFMPWTLLVILILVLNVPQDLFSWLYRTMKLPIAGLTADGKPLDTRALWQAYTWILVSTILAVPFLKPTGEQLRETVRTWVRRAPRPVFAAAVFFAIGEIMNMAGYDMAAGRFVVPSMVTVLADSSALAFQGMYGEVVAFIGLFGGFITGSEASTIAMFAKYTMTTAKNLDMPLSGLIIVTAGLAFGGGLASVISPAKLQNAAAAIDRIGEEGKVIRIAFVFALLLTLVTSLFVVVLLTVNGMGRVS
The following text describes a protein:
Function:
Involved in a F420-dependent anti-oxidant mechanism that protects M.tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron reduction of quinones to dihydroquinones, thereby preventing the formation of cytotoxic semiquinones obtained by the one-electron reduction pathway. In vitro, catalyzes the reduction of menadione to menadiol; since menaquinone is the sole quinone electron carrier in the respiratory chain in M.tuberculosis, the physiological electron acceptor for Fqr-mediated F420H(2) oxidation is therefore likely to be the endogenous menaquinone found in the membrane fraction of M.tuberculosis.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MDISRWLERHVGVQLLRLHDAIYRGTNGRIGHRIPGAPPSLLLHTTGAKTSQPRTTSLTYARDGDAYLIVASKGGDPRSPGWYHNLKANPDVEINVGPKRFGVTAKPVQPHDPDYARLWQIVNENNANRYTNYQSRTSRPIPVVVLTRR
The following text describes a protein:
Function:
Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Potential virulence factor (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MKKCIKTLFLSIILVVMSGWYHSAHASDSLSKSPENWMSKLDDGKHLTEINIPGSHDSGSFTLKDPVKSVWAKTQDKDYLTQMKSGVRFFDIRGRASADNMISVHHGMVYLHHELGKFLDDAKYYLSAYPNETIVMSMKKDYDSDSKVTKTFEEIFREYYYNNPQYQNLFYTGSNANPTLKETKGKIVLFNRMGGTYIKSGYGADTSGIQWADNATFETKINNGSLNLKVQDEYKDYYDKKVEAVKNLLAKAKTDSNKDNVYVNFLSVASGGSAFNSTYNYASHINPEIAKTIKANGKARTGWLIVDYAGYTWPGYDDIVSEIIDSNK
The following text describes a protein:
Function:
Involved in double-strand break repair via non-homologous end joining (NHEJ); the repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity.
Subcellular Localization:
Nucleus.
Sequence:
MKFFLSLKDFKGEKFVLRSELDESSAFLCAISPTCRYVLRDEIPWKRLQRNVTSESLTDELIVDLLCGRSESKHTLQLVVLENLCRIYINYVDPFPLRIAWFELEQQALKDHEHFDVLWECSHSIKDLALASMAQQKNELQKLMAYTEQLQEECKSRERKLIMKFADMIKNARNNEDNEDNHHINYEDESDVGTDEQKQQEGVNSSAVSDTDESAVSDEFMQIKEEFPMKALSASPTADASPESAGEDDSHRRSSHESSETVSE
The following text describes a protein:
Function:
Involved in the active transport across the outer membrane of iron complexed with linear hydroxamate siderophores coprogen, rhodotorulic acid and ferrioxamine B. Binds Fe-coprogen with high affinity, rhodotorulic acid to a lesser extent, and weakly to ferrioxamine B. Selective for planar siderophores. Does not use cyclic siderophores ferrichrome nor ferrioxamine E as substrates.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MLSTQFNRDNQYQAITKPSLLAGCIALALLPSAAFAAPATEETVIVEGSATAPDDGENDYSVTSTSAGTKMQMTQRDIPQSVTIVSQQRMEDQQLQTLGEVMENTLGISKSQADSDRALYYSRGFQIDNYMVDGIPTYFESRWNLGDALSDMALFERVEVVRGATGLMTGTGNPSAAINMVRKHATSREFKGDVSAEYGSWNKERYVADLQSPLTEDGKIRARIVGGYQNNDSWLDRYNSEKTFFSGIVDADLGDLTTLSAGYEYQRIDVNSPTWGGLPRWNTDGSSNSYDRARSTAPDWAYNDKEINKVFMTLKQQFADTWQATLNATHSEVEFDSKMMYVDAYVNKADGMLVGPYSNYGPGFDYVGGTGWNSGKRKVDALDLFADGSYELFGRQHNLMFGGSYSKQNNRYFSSWANIFPDEIGSFYNFNGNFPQTDWSPQSLAQDDTTHMKSLYAATRVTLADPLHLILGARYTNWRVDTLTYSMEKNHTTPYAGLVFDINDNWSTYASYTSIFQPQNDRDSSGKYLAPITGNNYELGLKSDWMNSRLTTTLAIFRIEQDNVAQSTGTPIPGSNGETAYKAVDGTVSKGVEFELNGAITDNWQLTFGATRYIAEDNEGNAVNPNLPRTTVKMFTSYRLPVMPELTVGGGVNWQNRVYTDTVTPYGTFRAEQGSYALVDLFTRYQVTKNFSLQGNVNNLFDKTYDTNVEGSIVYGTPRNFSITGTYQF
The following text describes a protein:
Function:
Serine protease effector that inhibits host cell autophagy by targeting SNX17. Localizes to the host endoplasmic reticulum-mitochondria contact site and catalyzes degradation of host SNX17, thereby impairing endoplasmic reticulum-mitochondria communication, leading to inhibit autophagy as well as staurosporine-induced apoptosis.
Subcellular Localization:
Secreted. Host mitochondrion membrane. Note=Localizes to the host mitochondria-associated endoplasmic reticulum membrane (MAM).
Sequence:
MIQRGFTMQERREKQGNNSPYLLTPYEMANLVFKTGAISFTVSAGTQPFQYLLNKLQFSQSGTPSGLSGGLFRGMYRGFLPYAIAGQKRGAVAVTHKQTNKVTEEEEFEAPFRQRWWGTIFFSQADLLVSNGLSGKARLQNVGVINAENFKWSLSNFWKLTSVNWGSRSFAGGVNFALIGFAGDYVSSFYKFDKDLYNKILGGATSGVIATLFTTAPNAYADSKLLQTKVAENNRLITVSPYTMFGQMKSHVKAVGLKEAFMTFFKVSYLQQVAVRAPQAAITFALIFGMDEYMGPQPLKKVWPGRVEELESENPSPSPTKK
The following text describes a protein:
Function:
Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Promotes the recruitment of the methyl donor, S-adenosyl-L-methionine, to RNMT. Regulates RNMT expression by a post-transcriptional stabilizing mechanism. Binds RNA.
Subcellular Localization:
Nucleus.
Sequence:
MSDTSEEIPNFEEMFASRFTKDDKEYQEYLKRPPESPPIVEEWNSRAGGNQRNRGNWLQDNRQFRGRDNRRGWPSDNRSNQWHGRSWGNNNYPQQRPEPYYQQQYTQYGHNQRPPYGYY
The following text describes a protein:
Function:
Component of a RSP5 ubiquitin ligase complex which specifies polyubiquitination and intracellular trafficking of the general amino acid permease GAP1 as well as other permeases such as PMA1. The RSP5-BUL1/2 complex is also necessary for the heat-shock element (HSE)-mediated gene expression, nitrogen starvation GLN3-dependent transcription and pressure-induced differential regulation of the 2 tryptophan permeases TAT1 and TAT2.
Miscellaneous:
MISCELLANEOUS: Present with 339 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Domain:
The PY-motif is required for the interaction with RSP5 ubiquitin-ligase and the HSE-mediated gene expression.
Sequence:
MTFTFSTSSRKNGRPPLKSVSTEDNIHLLRKRRQQQLSSNSTDNSLHPNSGQTPRASDSQDDDIRSASTTNLDRLRQEREENSLEMDCTQSRLSHRANMLVDVLPSFEMYNALHRHIPQGNVDPDRHDFPPSYQEVRTQRMTILPSNDNSVERSQLTAVPGSENACNNATAHSLTNLHPLQTQHLTINSTRSGGQSLHSSSDTNISQIPFEDDLNDSDNIFIDKLYTLPKLSTPIEIDIRITKTASIPHERPEEQSILKEYTSGDIIHGYCLIENRSSQPLKFEMFYVTLEAYISVIDRQKGKRTLKRFLRMVDLSASWSYTNITPSTGINIVPGERDFDDAIIGLSNSRELKPNTKYKKFFMFKLPTQLLDVTCKQEQFSHCLLPPSFGIDKYKNNCKYSGIKVNSVLGCGHLGTKGSPILTLDMADDNLSINYTIDAKIVGKDKRTSKLNIMKEKEYNLRVMPFPFAGVTNQQNEKTCLRQLKNLESLIEDRFEALNKIFKKLELNEAISNVDIHDTDISGTLDGNEDLDSDEILRRKLDQLHINNRIDDTASQSPSYDSKNMAPKENLVETELRYKFKNKNKSNSSLFSHFLSSSETGSSSTGPHVYNSGLIVLSVKKPQSTLPYWSPSLLRKTNKFEAKSEQEKENWQRLMGMLPEGVKTPLTKLDVHLTCIQSNNSAGHKPPEISSVTTEFVVITAKSDNSIPIKFCTELLMNENRLNKLKTKFLTYQKKVHEYRKKFEENHAKLNELYNRNRDHFTPKELLFTNFISDQINNDIDSLAGLKVNIIDLHDIFKKQIHTFEEENEDIISKKGSSNPPSASSSNNNFLQATFSNGASTATKFTQQIVHEWEKVKPLQYKRDVTVNLKLNPNIKETLVPNLETCLCCRFYCVRVNIKFDNHLGSMKVDIPVDVKKLQI
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.
Sequence:
MKLEKHLIKLNKQFSNKEEAICYCGQVLYEGGYVNEDYIEAMIERDKELSVYMGNFIAIPHGTDAAKNDVLKSGITVVQVPRGVDFGNVSNPQVATVLFGIAGIGNEHLEIIQKISIFCADVDNVLKLADAQSKEEVLRLFDAVE
The following text describes a protein:
Function:
Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MIEIKMNIRWNVILGVIALCALAWFYSLNQETADLSELVKKPDSPDYVGYKMETTVFSPDGKKQYLALSDKIEHYTVNEQTLFTAPLVYLYPTTSNEKEKEKNANQNVDFFSTQSWKLSANQARLTKDQILYLEGNVVAQNLTSDSRLQRIETESAVVNLKTQDITSETQVKIKGKNFSSTGLKLVGNLRQQVATLKEQVKTYYEVSKQ
The following text describes a protein:
Function:
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MVKQRILTAGKNPPSSTATRLPPPHVNVRSRLNDLLHLPSSAPTTMNSSNVSPIPSHNTESEHYLQQLESTILYAASTGSPDSSHRLDIERCQSSDGLAGACLDLLRRRGWGVTDYAAQQFAKGGISCAQFDAVAFYALTTLQRSPLLACLPPTNGSSDNTNATQQNINLPLLRNQLRLLLLTTISHCASLQTMPTFVSTKVGVLLALLVLEDYPMNWASPWTDILGALSVHTGRMGNLSEVNTTDGSSNISVCENVASQDMYLRFLDCISDEIVYPAADNENNKDSSSSSSLSSNSQYISTRRDQVKDVLRGFTIDSPNNQQGVQEPSIPLENTDAAQIIGWLLDAITTNATTNYNNGATGGEFEQEKRKVAVRAAATLKRYLSWVDLRLAAHPNLVQCLLQGLGGASAGNPSSNATTDDLDDAIIDEDDIDATPGTLLAVECALCLREIITRGMDESKKVALLHELNIFGTVCRLAGFGNSATNGTQGKLDLTNPDATQIDAVIAAAELINTAGLEFIPCWELEYQTASTNVPSSHPVNVIMNQCLELTLGCLAYDDIDVSGGVVDLVTRMLVSLEKNEPFWNNTLQNNGEIPSDRLLQRVLSILQERMKYPSSFDFDYEDEDEAEEEVYRTHLRKLYQRIVRFKPQMVLHFMAASLSSLPQPLSMVSTSDMEVALRLVHHYGEGRRPAPGAKTALRDAQFREMVTALHRSDVSSHPHREVLLLYYDLSVRYASLLKDSPPELLSGLLGALSGDRGLQHPHARVRSRCCYLLLRLVKSVGAKAMRPYVEVVVDGIQRLLFPSTNILQLPANEALYLFEITGTLLGTTGLDNEVQQRCATAVLTPHVQSIEKTLQSPDLARDVEQYGEQLSMSISAIAQLSKGWQNHPPPEVQAVLVAAVDVCRSVLVALPSSPLVRNRTAVLLQRMILCLGERVLPTMPAFLDALLSHCSTEEDVLDVSQLLNQLCIKFKENAAPAIDVALLPFLQKVLTMQLSETSVVPTASCVAPPPHLVTEQLSIRKQAFATLQHIATHNASAVFFSERNVGSFGDILSLMNDGATTVPDPVMKKTCVVYMSELVQQWGGTNSEPCPVPQNVKDGFFDFICEVFVPGMLRCILDSSFNAKDALHYRVLSEFSNVLWFLKQSSAEFQSRVMEAFVLGGSGTGVIPRGSPNIASGLQNASSGKEMESYLKAWKDEVVSQR
The following text describes a protein:
Function:
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.
Subcellular Localization:
Nucleus speckle.
Sequence:
MASNQIISIEQQGGNKKIKRPSNCFFIFSKMMRPNFVAQNPEREFYKKEAEKEKEKHSQDNPGYKYRPKRKSNSQYVRPNKKAKFDLHSHSHLQNAYNGNTAPQQQTQQQQPPLHHEQLTHQKIHFLTNPFYQMTFNTATQLQQPQQHTDFYTNPSYQMAYDPLHQNLQ
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm.
Sequence:
MNQDDNGKNVVSKVSDLTSCSDFSTSSPVPCLNPLSHENNRIDLIRDLLASLSKEGVVAVYNHVRSLLFTDFTEVFPEEVSLRVFSYLDQLDLCKCKLMSKRWKRLLEDPGIWKALYMQKGWFVNENVLNEFEAWRRTHKFPQPRFENFLKQQNIIGPYGTMFLPQQFIFDSNGRPLLNWSYLYKEHAHLDSNWRHGRFLVSTFNNPSIRFPADQDFRATLDSVYCVQYDDEIMVSGSKDRTVSVWDVNSRFILYKLYGHSGSVLCLDFCRRRNLLVSGSSDSTIIIWDWQNRRPLKVYFGHTDNVLGVVVSENYIISSSRDHTARVWRLDATSPAEACMHVLRGHLASVNSVQYSSKTGLIVTASSDRTLRTWDITTGHCIRIIHAHQRGIACAQYNGKFIVSGSSDLTIRIFEASSGKLLRMLQGHEDLIRTVRFNDEKIVSGGYDGTVRIWNFNTGEQHCVLHNSRNSRVFGLQFDHRRIIACTHSSEILVWNFDDGLDCTFF
The following text describes a protein:
Function:
Molecular chaperone which promotes the proper subunit assembly and surface trafficking of alpha-7 (CHRNA7) nicotinic acetylcholine receptor. Promotes the proper subunit assembly and cell surface expression of alpha-8 (CHRNA8) nicotinic acetylcholine receptor (By similarity). May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4 (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Domain:
The coiled-coil domain mediates transient homodimerization with other acetylcholine receptor-bound RIC3 molecules, promoting stepwise ACHR homomeric assembly at the membrane.
Sequence:
MAYSTVQRVALASGLVLAVSLLLPKAFLSRGKRPEPPPGPEGKLDRFPPMMHHHSAPSDGQTPGARFQRSHLAEAFAKAKGAGGGAGGGGSGRGLMGQIIPIYGFGIFLYILYILFKLSKGKTAEDRNCSTAPPGNAHRKITNFELVQLQEKLKETEEAMEKLINRVGPNGESRAQAVTSDQEKRLLHQLREITRVMKEGKFIDTSPEKEAEEAPYMEDWEGYPEETYPIYDLSDGIKRRQETILVDYPDLKEPSAEEIAEQMGEIEEEGSERLSWDHLPTDPGAQKDNSVAPCDPKPESCSCCVHEEEDPAVLAENAGFSADGYSEQEEATKENLPQDFTNEGLGVSTDNAHVGGMLRKRNPQGFE
The following text describes a protein:
Function:
Transcription factor that negatively regulates jasmonate (JA) signaling. Negatively regulates JA-dependent response to wounding, JA-induced expression of defense genes, JA-dependent responses against herbivorous insects, and JA-dependent resistance against Botrytis cinerea infection. Plays a positive role in resistance against the bacterial pathogen Pseudomonas syringae pv tomato DC3000.
Subcellular Localization:
Nucleus.
Sequence:
MVTGNMLWSGEDKAMVASVLGKEAFEYLMSGSVSAECSLMAIGNDQNLQNKLSDLVERPNAANFSWNYAIFWQISRSKSGELVLGWGDGCCREPKEAEEREVKKILNLRLDDEGQQRMRKRVLQKLHMLFGGTDEDNYAFGLDRVTDTEMFFLASMYFSFPRGEGGPGKCFGSGKYLWLSDALTSNLDYCARSFLAKSAGMQTIALIPTDVGVVELGSVRSIPESLELLQNIKSCFSSFLSLVRDKQAAGIAAVPEKNEGNNPRLSNSGAVTERTDGNPKIFGHDLNSGTHFREKLAVRKAEERPWDMYQNGNRMPFVNARNGLNPASWAQFSNVKLGKPVELYAPPTPGHNLMNGGREEFRLNNFQHQKPAARMQIDFTGATSRTIVSPAHNVESEHSDVEASCKEDRAGPVDEKRPRKRGRKPANGREEPLNHVEAERQRREKLNQRFYALRAVVPNISKMDKASLLGDAIAYITELQKKLRDMESERELRLGSTSRDAITSEDSPSSEIQIRGPDINIEAANDEVIVRVSCSLETHPLSRIIQIFKEAQINVVESKLSAGNGTVYHTFVIKSSGSEQLTKEKLLAAFSSESNSLRQLSPKLHKVILPSLF
The following text describes a protein:
Function:
Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins. Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains. Not able to deubiquitinate substrates with shorter ubiquitin chains. Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation.
Sequence:
MSWKRNYFSGSRGSVQGMFAPRSSMSIAPSKGLSNEPGQNSCFLNSALQVLWHLDIFRRSFRQLTTHKCMGDSCIFCALKGIFNQFQCSSEKVLPSDTLRSALAKTFQDEQRFQLGIMDDAAECFENLLMRIHFHIADETKEDICTAQHCISHQKFAMTLFEQCVCSSCGATSDPLPFIQMVHYISTTALCNQAICMLEKREKPSPSMFGELLQNASTMGDLRNCPSNCGERIRIRRVLMNAPQIITIGLVWDSEHSDLAEDVIHSLGTCLKLGDLFFRVTDDRAKQSELYLVGMICYYGKHYSTFFFQTKIRKWMYFDDAHVKEIGPKWKDVVTKCIKGHYQPLLLLYADPQGTPVSAQDLPPHAQFLPYTKTCYDSEDSGHLTDSECNQKHTSKKGSLVERRRSSGRVRRKGDEPQASGYHSEGETLKEKQAPRNASKSSSSSRLKDFKETVSNMIHSRPSLASQTSAGSPCVGRAGDQLDKIPPRNFPLQARGWETESTSSEAKSSSSSKYRPTWRPKRESLNIDSIFSKDRRKHCGYTQLRTFPEDAAKEFTPDEVSKPTANDIKDGGSRSQHKLWGTARPGSHLLEQHPRLIQRMESGYESSERNSSSPVSLDAAPPDSVNVYRDQSTKRPVGFVPSWRHIPKSHSSSILEVDCTAPMTSWTKTQPLSDGEVTSRSELDELQEEVVRRAQEQELRKKREKELEAAKGFNPHPSRYMDLDELQNQGRSDGFERSLQEANSIFEESLHLEQKGDCAAALALCNEAISKLRLTLHDASSSTHSRALVDKKLQISIRKARSLQDRMQQQASSQQPVQPSASLPSQGGALPQPTSEQPITLQVLLNQEAQLEPCKDTELGATSSFFHSPASCPELHSSLIPESPVSSVSQHSPPGTSSLKLLTSFEVDSVNRSAFHRQGLPKATGRTEMNSQHECLPLDALEDRLQGHREDNSCCSKFPPREGRDIAQDQLFEGKKNPADISMGMPWSYSTGEATSERVIYSLNSPSSSSAQPSIPPYSSCHPITSAASSPVLHAADPMQKLNQHVQAQSLQTSLTSKVVRSSEEPYRLEFPSTKGLVRSLAEQFQKMQNTSTRDVIGSQDRSLPNGVRKSSSPSDFMPPLSQGPGREHCRWVKQPRSPDGRERPPCWEDPAAHPPLSMGSGLPDGETSRTAQPRLAEPDMYQGKLPQVTDIRSKELGSSVNLGTSLPLDSWVNVTRLCDSQVKPSAPGPGDKSSSHDSHPRATCLERSPILLHPHWDQDTEQETSELESLYQASLQASSHTAYSDWRSQDVAWQPLSLAGSADGMGRRLHSAPGLDLSKPLTAEMEHVLYEPSTVPVSQDSSNVRKKTLETGHHCSSSSSLPVIHDPPVFLLDPKLYPPQPQFLSPDVLMPSMAGEPYRPPGTSRSVHQFLAMCDRDETPQGVKYTGRTLNYRSLPHRSRTDASWGPGSETNQHIGARVLTMPACKPQLTYTATLPERHQGLQVPHAQSWGNLFHSPSHPSAVHPGSPPSSNLHVPLRSTWNSGPVLGSRTPGPRRIDMPPDDDWRQSSYPSQDRHRSPGEERIMFALSNAAGREQNRVRFLQHSRW
The following text describes a protein:
Function:
Involved in vision.
Subcellular Localization:
Cell projection, cilium, photoreceptor outer segment. Membrane; Lipid-anchor; Cytoplasmic side. Endoplasmic reticulum. Golgi apparatus. Note=Localizes to photoreceptor disk membranes in the photoreceptor outer segment. The secretion in media described in PubMed:24992209 is probably an experimental artifact.
Sequence:
MCTTLFLLSTLAMLWRRRFANRVQPEPSDVDGAARGSSLDADPQSSGREKEPLK
The following text describes a protein:
Function:
May be a carrier protein for lipids.
Subcellular Localization:
Secreted.
Sequence:
MRASAVFLSSFIISIQAAAFNNPEDELRRSAACLEQSKVSSESIKNLQIGNFDDDERLKEYLFCVSKNAGYQDPAGHLQHEMIRLRFKGGRYSDDTINEVLQQCGHQKDTPQETAFQFMKCAYQNAFPRNYK
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (Probable). Plays an important role in the phosphorylation of EIIA-deficient PTS transporters. The EIIA domain can transfer a phosphoryl group to EIIA-deficient PTS transporters, enabling growth with maltose, N-acetylglucosamine, sucrose or trehalose as the sole carbon source.
Subcellular Localization:
Cytoplasm.
Domain:
The PTS EIIA type-1 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-1 domain.
Sequence:
MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMMGEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFTAHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGESKLFTIKAK
The following text describes a protein:
Function:
Toxic component of a type III toxin-antitoxin (TA) system. An endoribonuclease which cleaves between the first and second A of AAAAA sequences; it tolerates other nucleotides in positions +2 and +4 of the consensus. Digests cognate antitoxin RNA ToxI as shown by the 2'-3'-cyclic phosphate at the 3' end of the 34-nt repeats and probably other RNAs. Inhibits growth when expressed in E.coli without causing cell lysis; this bacteriostatic effect is neutralized by cognate RNA antitoxin ToxI, which has 2.9 nearly identical 34 nucleotide-long repeats. Non-cognate antitoxin RNA from P.atrosepticum does not inhibit this toxin. The toxin-antitoxin pair function in plasmid maintenance (a plasmid addiction system), but unlike its P.atrosepticum homolog it is not seen to confer resistance to bacteriophages.
Miscellaneous:
MISCELLANEOUS: Encoded on a conjugative plasmid that includes genes for a type IV secretion system.
Sequence:
MTNKDNPKFHTISTEYIDYLREADSKVPFNKDEQHSRPYVGVLEKINGHDYFVPLTSRNDKNFNSQVSVKLFDNDEKRIGVLLVNNMIPVPEKECKEIDIAEKTAADPQYGNLMLKQYLFLKENMDRVTNKVEKVYKDVTVQGKPSHKQKFLKGVCCDFPKLEEKCQEYKERDQAKERDKARRIAYMRQMGRER
The following text describes a protein:
Function:
Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP-mannose as its preferred substrate, yielding GMP and mannose-1-phosphate.
Domain:
In the dimer, the N-terminal domains are swapped between the two monomers, such that residues of both chains contribute to the active site.
Sequence:
MSVKIENIQCELLSKNWFKLHKYTFDLKTDEGTSVQQIREVYDRGNGATILLYNRQQGTVVLIEQFRMPTYVNGNASGMLLEACAGLLDNDSPEACIRREAMEETGYQVDKVQKLFEAYMSPGGVTELVYFFAAEYHPDQKITDEVGVEDEVIEVVELPFHDALAMVADGRIKDGKTIMLLQYAQIHFFPSSLTPQRC
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MEEAEELLLEGKKALQLAREPRLGLDLGWNPSGEGCTQGLKDVPPEPTRDILALKSLPRGLALGPSLAKEQRLGVWCVGDPLQPGLLWGPLEEESASKEKGEGVKPRQEENLSLGPWGDVCACEQSSGWTSLVQRGRLESEGNVAPVRISERLHLQVYQLVLPGSELLLWPQPSSEGPSLTQPGLDKEAAVAVVTEVESAVQQEVASPGEDAAEPCIDPGSQSPSGIQAENMVSPGLKFPTQDRISKDSQPLGPLLQDGDVDEECPAQAQMPPELQSNSATQQDPDGSGASFSSSARGTQPHGYLAKKLHSPSDQCPPRAKTPEPGAQQSGFPTLSRSPPGPAGSSPKQGRRYRCGECGKAFLQLCHLKKHAFVHTGHKPFLCTECGKSYSSEESFKAHMLGHRGVRPFPCPQCDKAYGTQRDLKEHQVVHSGARPFACDQCGKAFARRPSLRLHRKTHQVPAAPAPCPCPVCGRPLANQGSLRNHMRLHTGEKPFLCPHCGRAFRQRGNLRGHLRLHTGERPYRCPHCADAFPQLPELRRHLISHTGEAHLCPVCGKALRDPHTLRAHERLHSGERPFPCPQCGRAYTLATKLRRHLKSHLEDKPYRCPTCGMGYTLPQSLRRHQLSHRPEAPCSPPSVPSAASEPTVVLLQAEPQLLDTHREEEVSPARDVVEVTISESQEKCFVVPEEPDAAPSLVLIHKDMGLGAWAEVVEVEMGT