lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MNNFFQGYNLLFQHSLFASYMDWFHAFNCSLLLGVLVFVTLLFGYLIFSTFYFKSKKIEYQFGELLCSIFPTIILLMQMVPSLSLLYYYGLMNLDSNLTVKVTGHQWYWSYEYSDIPGLEFDSYMKSLDQLNLGEPRLLEVDNRCVIPCDTNIRFCITSADVIHAWALNSLSVKLDAMSGILSTFSYSFPMVGVFYGQCSEICGANHSFMPIALEVTLLDNFKSWCFGTME
The following text describes a protein:
Function:
Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGIGADEKKPLLVQLDGQYYDIADFAPKHPGGAKVLNRLAGEEIGEFIRGEKRIMGVRHEHSEAAYNMLERYNVNAIQKGDPLIESKSGMLFKVGSLGSEYWHWIHQPYDGTLRLFDSDVLESMTRTAWWVVPAVWMPIVITFSILSVLSFSTSTDVYNSILLWSAWFVIGVLTWTLTEYSLHRWVFHWKPSPDSPNQILLHFLAHGLHHKTPMDGDRLVFPPVPATLIVGIFYLIYSNTFQWPVFCAFGAGKLFGYVTYDMVHYYLHHGSPRPRSNLHFRKVYHHNHHFKNFDVGFGISTSLWDYVFHTLGMGPL
The following text describes a protein:
Function:
Heterogeneous nuclear ribonucleoprotein (hnRNP)-protein binding the poly(A) tail of mRNA and probably involved in some steps of pre-mRNA maturation.
Subcellular Localization:
Nucleus.
Sequence:
MQSNGSDSQQLQQEQNKVQQQPPPPPPPPQQHQQWMAMQYPAAAMVMQHQMMPPQHYAPPPPQHYMAAYHQYHQHHPHLQQPPQQHHQNQGSSGENKTIWIGDLHHWMDENYLHTCFASTGEIASIKVIRNKQTGLSEGYGFVEFFTHAAAEKVLQNYTGILMPNTEQPFRLNWATFSSGGYASNGASGQGFQSDGDSTNTTIFVGGLDPNVTDEDLKHPFSQYGEIVSVKIPVGKGCGFVQFGNRSNAEEALQKLNGTVIGKQTVRLSWGRNPANKQFRSDFGNQWSGAYYGGQVYDGYGYALPPPHDPSLYAATAAAYAAYPVYGSHQQQVS
The following text describes a protein:
Function:
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Subcellular Localization:
Membrane.
Sequence:
MLLNWLRIYRYLLPVRACVRGHYQVDEPFSYGSLRFKNRIGLSAGFDKNAETFDELADFGFGFLEVGTVTPDYQPGNPSSRIFRLVEDESLISRTGFNNCGVDVALAHIRRHRKHSYILGVNINKNPLSVGEQIIKDFELVFTRLYESVDYFTLNWGSIDKESFAKVLENFTTFREAVNKRCSIFIKLPADIDEKELDLVISLAYKYSIEGFIATGPTMDRSELHQTKTKQLEKIGNGGVSGRGIGKKSQKVVHYLSEHTDRHFLIIGAGGIMTAEDAADMISQGADMVQIYSAFIYSGPSVVHKIGKKLKH
The following text describes a protein:
Function:
Required for efficient assembly and nuclear export of the 60S ribosomal subunit. Involved in asymmetric localization of ASH1 mRNA.
Miscellaneous:
MISCELLANEOUS: Present with 3650 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAPKKPSKRQNLRREVAPEVFQDSQARNQLANVPHLTEKSAQRKPSKTKVKKEQSLARLYGAKKDKKGKYSEKDLNIPTLNRAIVPGVKIRRGKKGKKFIADNDTLTLNRLITTIGDKYDDIAESKLEKARRLEEIRELKRKEIERKEALKQDKLEEKKDEIKKKSSVARTIRRKNKRDMLKSEAKASESKTEGRKVKKVSFAQ
The following text describes a protein:
Function:
Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.
Subcellular Localization:
Lysosome. Secreted. Apical cell membrane; Peripheral membrane protein; Extracellular side. Note=Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells.
Sequence:
MWGLKVLLLPVVSFALHPEEILDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPPSRSHSNDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENYGCGGGYMTNAFQYVQRNRGIDSEDAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDENCSSDNVNHAVLAVGYGIQKGNKHWIIKNSWGESWGNKGYILMARNKNNACGIANLASFPKM
The following text describes a protein:
Function:
May be required for replication-independent chromatin assembly (By similarity). May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MIRIAALNASSTIEDDHEGSFKSHKIQTKEAQEAEAFALYHKALDLQKHDRFEESAKAYHELLEARLLREAVSSGDEKEGLKHPGLILKYSTYKNLAQLAAQREDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCLYFICKALEKDCRYSKGLVLKEKIFEEQPCLRKDSLRMFLKCDMSVHEVSVNAAETQAIVDEALGLRKKRQALIVREKEPDLKLVQPIPFFTWKCLGESLLAMYNHLTTCEPPRPSLGKRIDLSDYQDPSQLLAPSIVVTPVSVVQPSPVCTNPTVAVAEPVLSYTSVTTTSFPLHSPGLLDTGTPMGDVSGGDKSKKGVKRKKTLEESGETAKRRSARVRNTKCKKEEKVDFQGLLVKFLPSRLRKLDPEEEDDPFNNYEVQSEAKLESFSNVGPHRLSFDSATFMESEKQDVHAFLMENLTNGGVLELMMRYLKSMGHKFLLKWPPGLAEVVLSVYHSWRRHSTSLPNPLLRDCSNKHIKDMMLMSLSCMELQLDQWLLTKGRSSTVSPRNCPAGVVTGRFGPDFPGTHCLGDLLQLSFASSQRDLFEDGWLEFVVRVYWLKARFLALQGDMEQALENYDICTEILQSSTALQAQAGAEQRDIVIRLPNLHNDSIVSLEEIDKNLKSLERCQSLEEIQRLFEAGDYKAVVQLLRPTLCTSGFDRAKHLEFMTSIPERPAQLLLLQDSLLRLEEHRQCFECSDVALNEAVQQMLNSSDSAAKEEWAATVTQLLLGMEQALSSDSRGSILKESSSPTGLVRLTNNLIQVIDCSMAVQEEPKEPYVSSVLPWIILHRIIWQEEDTFRSLCHQQQLQNPTEEGISEMPMLPSSLMLLNTAHEYLGRRSWCCNSDGALLRFYVHVLQKELAASASEDTHPYKEELETALEQCFYCLYSFPSKKSKARYLEEHSAQQVDLTWEDALFMFEYFKPKTLPEFDSYKTSTVSADLANLLKRIATIVPRTEKPALSMDKVSAYIEGTSAEVPCLPDGADPAPPVLNELYYLLADYHFKNKEQSKAIKFYMHDICICPNRFDSWAGMALARASRIQDKLNSNELKSDGPIWRHATPVLNCFRRALEIDSSNLSLWIEYGTMSYALHSFASRQLKQWRAELPPEVVQQMEDRRDSMLETARHCFTSAAHCEGDGDEEEWLIHYMLGKVAEKQQQPPTVYLLHYRQAGHYLHEEAARYPKKIHYHNPPELAMEALEVYFRLHASILKLLGKPDSGVSAEVLVSFMKEAAEGPFARGEEKNTPKASEKEKACLVDEDSHSSAGTLPGPGASLPSSSGPGLTSPPYTATPIDHDYVKCKKPRQQATPDDRSQDSTAVALSDSSSTQDFFNEPTSLLDGSRKLLPEKRISGLSAQAGPSGKDLPGPTEERGKTEESLESTEAFRVVEPSVQKPVADSSASAYIPSKPAVSTPPPWDGKKRSDPLGEPVAFPQGLPAGAEEQRQFLTEQCIASFCLCLSRFPQHYKSLYRLAFLYTYSKTHRNLQWARDVLLGSSIPWQQLQHMPAQGLFCERNKTNFFNGIWRIPVDEIDRPGSFAWHMNRSIVLLLKVLAQLRDHSTLLKVSSMLQRTPDQGKKYLRDADRQVLAQRAFILTVKVLEDTLSELAEGLEHPGSKACGLSGARMTTDVSHKASPEDGQESLPHPKKLPLADGSGPGPEPGGKVGPLHQLPVATDTRDNTEQGGEPKDKERPPVGPTEPMDTGETAARHPDLEPTPRLLPGRPPRDRGPESRSAELSLEELSISTRQQPAPLVPSPVTPTTAAPTTMGARAAGHPEEAPPRPNRKRKLLQDTESGKTLLLDAYRVWQQGQKAMAYDLSRIEKIMSETYMLIKQVDEETALEQAVKFCQVHLGAAAQRQASGDAPTTPKHPKDSRENFFPATVAPSAPDTTAPDALQRPSDSHLKPGLAAAITCPPSASASTPDPGIPQPHRPEAVPSRAPLSPDGEEVSGVTEGPSFLSQEPRHSHQMKMAATGPLAEQHCWPVEAACQTGAEPTFSQATSTKVPSSGSTQTPESHQGKTESSRAKSRLLPNMPKLVIPSATTKFPPEITVTPPTPTLLSPKGSISEETKQKLKSAILSAQSAANVRKESLCQPALEVLETSSQESSLESETDEDDDFMDV
The following text describes a protein:
Function:
Required for the maintenance and/or establishment of both the shoot and root meristems, probably by controlling the expression of the meristem genes and of genes required for auxin responses. Involved in the development of the basal pole and in auxin-mediated root and vascular development in the embryo (By similarity). Confers sensitivity to turnip mosaic virus (TuMV) probably by promoting viral movement and multiplication via interaction with TuMV VPg (Probable).
Subcellular Localization:
Nucleus.
Sequence:
PTADAIAAKKMENGKAAIDFPDQSVIRRVSSADRISLQDIARERVDVICDRMHRLPDEFLDELKNGLRAILEGGNGSQHRDEFFILQKLVQSRSDLTAKTLIRAHRVQLEILVSINTGIQGFLHPSISLSQTSLIEIFLYKRCRNIACQNQLPADECSXDTCTNNNGFCNLCMCVICSKFDFEVNTCRWIGCDLXSHWTHTDCAIREQLICMGPSVKSGSGPSEMVFRCQACSXTSXLLGWVKDVFQHCAPSWDGDALIRELDFVSRIFHGSKDQRGMNLFWKCDDLKEKLKSRKMDSKAACRAILMVFQELDLDNSKSLENAESGRLIAPQEACNRIAEVVQEAIRKMEFVADEKMRMFKKARIAVEACDRELADKAREAGDLKVERQKKKSQIEELERIVRLKNAEADMFQLKANEAKREAERLQRIALAKSDKSEEEYTSNYLKQKLSEAEAEKQYLYEKIKLQESSRLSQSSGDPSSMLMYSKIHDLLYNGPPKADSQSNDCHPFRTNP
The following text describes a protein:
Function:
Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSTRETFKISLLAKMPKDVINQFLSKDKTPFSVLFLSLLVGILAGLVGTYFEQAVHLVSETRTDWLKSEIGSFLPLWLAAFLISAFLAFIGYFLVHRFAPEAAGSGIPEIEGAMDGMRPVRWWRVLPVKFFGGMGALGSGMVLGREGPTVQMGGAVGRMISDIFRVKNEDTRHSLLAAGAAGGLAAAFNAPLAGIMFVIEEMRPQFRYTLISVRAVIISAVAANIVFRVINGQDAVITMPQYDAPELSTLGLFLLLGALFGVFGVLFNYLITLAQDLFVKFHRNDRKRYLLTGSMIGGCFGLLLLYVPELTGGGISLIPTITNGGYGAGILLLLFVGRIFTTLLCFGSGAPGGIFAPMLALGTLFGYAFGLIAKMWFPELNIEPGMFAIAGMGALFAATVRAPITGILLVIEMTNNYHLILPLIITSLGAVIFAQLLGGQPIYSQLLHRTLKNQKLQQQDLPPQSPNS
The following text describes a protein:
Function:
Involved in the breakdown of putrescine via the oxidation of L-glutamylputrescine.
Sequence:
MTEHTSSYYAASANKYAPFDTLNESITCDVCVVGGGYTGLSSALHLAEAGFDVVVLEASRIGFGASGRNGGQLVNSYSRDIDVIEKSYGMDTARMLGSMMFEGGEIIRERIKRYQIDCDYRPGGLFVAMNDKQLATLEEQKENWERYGNKQLELLDANAIRREVASDRYTGALLDHSGGHIHPLNLAIGEADAIRLNGGRVYELSAVTQIQHTTPAVVRTAKGQVTAKYVIVAGNAYLGDKVEPELAKRSMPCGTQVITTERLSEDLARSLIPKNYCVEDCNYLLDYYRLTADNRLLYGGGVVYGARDPDDVERLVVPKLLKTFPQLKGVKIDYRWTGNFLLTLSRMPQFGRLDTNIYYMQGYSGHGVTCTHLAGRLIAELLRGDAERFDAFANLPHYPFPGGRTLRVPFTAMGAAYYSLRDRLGV
The following text describes a protein:
Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.
Sequence:
MAEATLPNQSQPCGNNLLLVGSKQSPSSSEALQQQQSSIFSSISLSSYQVIPPVTHQPGSEPENTVAWTPPAQQTQDCPSGLEYLINLDKVLIKQQPDPLEMKSYTITPDRFIIKNKYDQQVFLGVEEGEPRQTLDIYRPIILKAYDRSGLEVFKVYRGSLPVYSLCSCSASSSVKIRLTFESPPGTLLYYLWPTSFKGHYYINDINGKCYVKVINKIKRKQFLESPPTEFNFDIYDYIENCLIGTMKKKWLGHQALSHEHSLEIDFLIDSPPGLKACIIAIGMLYDVYFFDNYTEHQNRIVEHNCGRKSFVNRK
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MTDIENQQPTDGQAPHKMPSSNDYLSNEYPSSDNEPFYNGDPQSPQYLNNEYYLPQTPQTQSTNKPIEPTSIHDLYARSNFNEDISAWNTIMNEPSEHSDFWITPEALTNFSQNATQLKKHNSFLWAIPFILNCLALIGLFFNFIRYHLDYMKYGINVAVPTIICYWISLAFVVMLVIEQCFPTITVRFGIFINLIIHLIGYFLKFKGFWEYIFVWLTFLVLGLFFYLITSGRAEYDIFMARLIRRKVYQTGNYIFLIFIVLVIMCCAICFPVYDSWTWFNSVNWIYQAYLTISFYNIVCVFGNCTYMSSSYMAAKWYLTGEKIGAKDVSKGLRTGFIDNIGVACKMSYLLPILEFVNAISRYSPQLTVYHIKDKYPLFAKHYCAVCGPIVRLFKKLAKFEMKLLGYPQRRAMTYCAIYGIPYEEAVHRYYEIQSTKGAPLVDDAFMFDTQLIFKQFSFGMVAFYFERFARRVKYGAFPGLNDALALFYVFAVYYSFRCITRGFLETVFVLFGELPEKANNIDPDLFDTLKEMFETSLKARNDDTDIKSDEV
The following text describes a protein:
Function:
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.
Sequence:
MALVGESRGRSRSRSAAFPETQTAALDTDTQEATDELPGYLAPLSSQLADSVSTDQKKRKRQIDSQQTRSTSSRRSAKRSRRDGYAKGPLLGRGGFGSVFAGIRRSDGLPVAIKYVSKDRTCETLRVAGQGRLPLEVALMIRVTSAPACPSVLQLLDWFDRPRRYILILERPAPCQDLQSFCEENGCLDERLAKRVLVQLIAALKHCESRGVLHRDVKPENLLISTETQDIKLLDFGCGDQLKSSAYRYFAGTPAYAPPEWFSRHRYHAAPATVWSVGVTLFNILCDRFPFGGARRVTSRSRLLFPRQLSTG
The following text describes a protein:
Function:
Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Membrane raft; Single-pass type I membrane protein.
Domain:
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Sequence:
MALRVLLLTALTLCHGFNLDTENAMTFQENARGFGQSVVQLQGSRVVVGAPQEIVAANQRGSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSLAATTSPPQLLACGPTVHQTCSENTYVKGLCFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQLKKSKTLFSLMQYSEEFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFNITNGARKNAFKILVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQELNTIASKPPRDHVFQVNNFEALKTIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAITSNGPLLSTVGSYDWAGGVFLYTSKEKSTFINMTRVDSDMNDAYLGYAAAIILRNRVQSLVLGAPRYQHIGLVAMFRQNTGMWESNANVKGTQIGAYFGASLCSVDVDSNGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGRARWQCDAVLYGEQGQPWGRFGAALTVLGDVNGDKLTDVAIGAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLSPRLQYFGQSLSGGQDLTMDGLVDLTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAGEVRVCLHVQKSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLPNCIEDPVSPIVLRLNFSLVGTPLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDDLSITFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRSQRSWRLACESASSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKANVTSENNMPRTNKTEFQLELPVKYAVYMVVTSHGVSTKYLNFTASENTSRVMQHQYQVSNLGQRSLPISLVFLVPVRLNQTVIWDRPQVTFSENLSSTCHTKERLPSHSDFLAELRKAPVVNCSIAVCQRIQCDIPFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFTLLPGQGAFVRSQTETKVEPFEVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDMMSEGGPPGAEPQ
The following text describes a protein:
Function:
May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
Sequence:
MFSIALCEDNSLQREELKNNLSKVLDEIGVEYKLLTFETGEDLLREYPENLDMLFLDIQMGELTGMETARKVRKYDDKVEIIFITALWDYIQKGYEVRAFRYLIKPVKFKELQEQVTACVENILHKRYTYITIKDKNNVLKIRTEDILFLETFERKVIIHTNSQDYIVKMSMNKLEKELNNKGFFRCHTSYIVNLIKIEEIKKDYLLINKFTLPVSKHRMKNLKLRLTSLLGDLIC
The following text describes a protein:
Function:
Catalyzes the attachment of leucine to tRNA(Leu) in the mitochondrion.
Miscellaneous:
MISCELLANEOUS: PubMed:3034607 authors identified this protein as the gene product of the NAM2 gene, which is capable of compensating for mutations in mRNA maturase encoded by the fourth intron of the mitochondrial cytochrome b gene; MISCELLANEOUS: Present with 2120 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MLSRPSSRFLSTKRGPGPAVKKLIAIGEKWKQKTTRGLPKQDTLNSGSKYILCQFPYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAENAAIERSINPAIWTRDNIAKMKQQMQSMLANFDWDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDPVDMTVLANEQVDAQGRSWRSGAIVEKKQLKQWFLGITKFAPKLKKHLNQLKDWPSNVKQMQKNWIGESVGAELVFKVADPKFENLIVFTTRPETLFAVQYVALALDHPIVQKYCEEMPDLKEFIQKSDQLPNDTKEGFQLPNIKAVNPLTKEEVPIFAAPYVVSSYGSAPSAVMGCPGHDNRDFEFWQTNCPGEHIKTCIAPFFDDASKVTEQERQRIIDTVPFTSTDGVLTKECGEHSGVLTVVARKSIMGMLNSEGLSKSVVRYKIRDWLISRQRYWGTPIPIIHCDNCGPVPVPESDLPVKLPELEGLDTKGNPLSTIDEFVNVACPSCGSPAKRETDTMDTFIDSSWYYFRFLDPKNTSKPFDREIASKNMPVDIYIGGVEHAILHLLYSRFIAKFLGSINAWSDPAGIFEPFKKLVTQGMVQGKTYVDPDSGKFLKPDELTFVNDSPDGNTVIIKSNGKVPVVSYEKMSKSKYNGADPNECILRHGPDATRAHILFQSPIADALNWDESKIVGIERWLQKVLHLTKNILSLEKDLAISKDYKTPTDLNDAEVKFHNDFQRFLKSITESFEVNLSLNTVISDYMKLTNILESALKKGEVRNEMIVQNLQKLVTVIYPAVPSISEEAAEMINSQMEWNQYRWPEVERTTESKFKKFQIVVNGRVKFMYTADKNFLKLGRDAVIETLMNLPEGRMYLMNKKIKKFVMKFNVISFLFHK
The following text describes a protein:
Function:
Has a role in the perception of gravity.
Sequence:
MSFNEGKMLPPSFEDFVTDYVLASLAMNNNNNSSTNNNNSNSNNNNLLSSSQQNNAKIEQEQPDSDTIKMFVGQVPRSMDENDLRRMFEEYGRVHSINVLRDKTTGASKGCCFVTFFTRKAALQAQDALHNVKTLNGMHHPIQMKPADSENRNERKLFVGMLSKKLCENDVRTLFSGYGTIEECTVLRDTAGNSKGCAFVTFASKQSALSAIKALHQSQTMEGCSAPLVVKFADTQKEKELKRQQQIQANVWNALAAPQLQTSPQQFSPVLSNDATSLQLLQAMSGGSALLPQQLLTGAENLLAPLGVQNLVTLAAMSQPTAAPLCVANLLGKGAGVERTLTTGLQTGMSTSDLSTYGSLITNATLNAAAIAAAGKQIEGPDGCNLFIYHLPQEFTDTDLASTFLPFGPVISAKVFIDKQTNLSKCFGFVSFDNATSAQQAIAAMNGFQIGTKRLKVQLKRAKDASKPY
The following text describes a protein:
Function:
Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MPNYKLLYFNMRGRAEIIRYIFAYLDIKYEDHRIEQADWPKIKPTLPFGKIPVLEVEGLTIHQSLAIARYLTKNTDLAGKTALEQCQADAVVDTLDDFMSLFPWAEKDQDLKERMFNELLTHQAPRLLKDLDTYLGDKEWFIGNYVTWADFYWDICSTTLLVLKPGLLDIYPKLVSLRNKVQAIPAISAWILKRPQTKL
The following text describes a protein:
Function:
Self-assembles to form a helical, filamentous nucleocapsid mesuring 400 nm in length and 20 nm in width (Probable). Together with capsid protein 2, wraps arounds the DNA and maintains it in an A-form (Probable). Capsid proteins probably maintain the DNA in A-form by non-specific desolvation and specific coordination of the DNA phosphate groups by positively charged residues (Probable). This certainly protects the viral DNA under conditions such as the extreme desiccation of its host (Probable).
Subcellular Localization:
Virion.
Sequence:
MSVVTTRARIAETLTEKHTLGIEKVVATDSWRVGITSREKKLERINISAEISRRIQDEAIAYARNKGIPYLPGINGIAWKLLRLKWLGYTDQINVVMRTVPAEWRDFLTQIMENTQMESMYSELRKVRV
The following text describes a protein:
Function:
Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. To a lesser extent, is able to slowly catalyze the deamination of L-threonine into alpha-ketobutyrate and that of L-serine and 3-chloroalanine into pyruvate. Is also able to rapidly convert vinylglycine to threonine, which proves that the pyridoxal p-quinonoid of vinylglycine is an intermediate in the TS reaction.
Sequence:
MKLYNLKDHNEQVSFAQAVTQGLGKNQGLFFPHDLPEFSLTEIDEMLKLDFVTRSAKILSAFIGDEIPQEILEERVRAAFAFPAPVANVESDVGCLELFHGPTLAFKDFGGRFMAQMLTHIAGDKPVTILTATSGDTGAAVAHAFYGLPNVKVVILYPRGKISPLQEKLFCTLGGNIETVAIDGDFDACQALVKQAFDDEELKVALGLNSANSINISRLLAQICYYFEAVAQLPQETRNQLVVSVPSGNFGDLTAGLLAKSLGLPVKRFIAATNVNDTVPRFLHDGQWSPKATQATLSNAMDVSQPNNWPRVEELFRRKIWQLKELGYAAVDDETTQQTMRELKELGYTSEPHAAVAYRALRDQLNPGEYGLFLGTAHPAKFKESVEAILGETLDLPKELAERADLPLLSHNLPADFAALRKLMMNHQ
The following text describes a protein:
Function:
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes The CSN complex is involved in the regulation of the mating pheromone response.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDLLKFSSLAISEINFLHESSFDSIDHSWFLLIGCKLDQDDEIYIPINGNEAESQWYIEKVIRIPMQENDKINQERLERRINLTKVTQKDICILGILDLCQLEEDENITNKVTEKVLTQLTALALKYLIKYNVFRQHTSFQEAVNSLKGYKIENSVQIGAEIILDFLQDKVQIKDVNDRYQIPTPNNTVDPGFDEFQLIDMKDKEINIQKYNNNTIRKLLEKINRMIIFLKNYDATDKPFSSTQDVILRKISMLVTQLQRGGTSDMNYLLDNKINEIKLLEISCKQWEISNMLKK
The following text describes a protein:
Function:
Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA. Probably participates in beta-oxydation and energy production but could also play a role in the metabolism of specific fatty acids to control fatty acids composition of cellular lipids in brain.
Subcellular Localization:
Mitochondrion membrane. Peroxisome.
Sequence:
MAQRTGELVGEVNSAHQLDNDALFRYCSSHVEGFPVSSSRFSVSQFGHGQSNPTYLLEVESGHLVKRYVMRKKPPGKLLQSAHAVEREFQVLHALGTHTLVPVPKVFCLCTDSSVIGTPFYVMEFLEGRIFLDPMLPGVAPDRRRALYHATANALASLHSADVDAIGLGSFGRRNNYCKRQVERWAKQYIASTGEGKSERNPKMLTLIDWLRENIPSEDSSGSTAGLVHGDFRMDNLVFHPIEDRVIGILDWELSTLGNQMCDIAYSSMLYIADFSQGKVKHNNGFELDISEGVPSLEEYLADYCSAAGKQWPVAGWKFYIAFSLFRGASILAGVHSRYIMGNASGGKRAQDAGEKANDLIQIAWSYIQRETVLSKNPPSVTKGKDEGLESGGRFVPNKKVKDLRDKLIKFIEERVYPMEQEFSKLAQSSMRWTVHPQEEKLKEIAKKEGLWNLFIPLDSAARAREILFDGRGDDAIGTGFPNQLGAGLSNLEYGYLCEIMGRSVWAPQVFNCGAPDTGNMEVLLRYGNKEQLQEWLIPLLSGTIRSGFAMTEPQVASSDATNIECSIRREGDTYVINGKKWWTSGAMDPRCKLLILMGKTDFKAPIHKQQSMILVDINTPGVKIIRPLTVFGFDDAPHGHAEVSFENVRVPAKNILLGEGRGFEIAQGRLGPGRLHHCMRLIGAAERGMQLMVQRSLQRRTFGKLIAQHGSFVSDLAKCRIELEKTRLLVFEAADQLDRFGNKKARGALAMAKVAAPNMAMKVLETAIQVHGAAGVSGDTVLAHLWATARTLRIADGPDEVHIGTIAKLELKRAKL
The following text describes a protein:
Function:
One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPQGETFHRAVSNVLFISQIYGLLPVSNVRALDVADIRFRWCSPRILYSLLIGILNLSEFGAVINYVIKVTINFHTSSTLSLYIVCLLEHLFFWRLAIQWPRIMRTWHGVEQLFLRVPYRFYGEYRIKRRIYIVFTIVMSSALVEHCLLLGNSFHLSNMERTQCKINVTYFESIYKWERPHLYMILPYHFWMLPILEWVNQTIAYPRSFTDCFIMCIGIGLAARFHQLYRRIAAVHRKVMPAVFWTEVREHYLALKRLVHLLDAAIAPLVLLAFGNNMSFICFQLFNSFKNIGVDFLVMLAFWYSLGFAVVRTLLTIFVASSINDYERKIVTALRDVPSRAWSIEVQRFSEQLGNDTTALSGSGFFYLTRSLVLAMGTTIITYELMISDVINQGSIRQKTQYCREY
The following text describes a protein:
Function:
Palmitoyltransferase that targets several endosomal SNAREs. Palmitoylates the SNAREs at cysteine residues close to the cytoplasmic end of their transmembrane domain. May have a role in the cellular quality control of transmembrane domain-containing proteins (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MLFTLIVCLTIISSLATFLLLFGDSPSFRNTPIQKLRNSLLSISRDIFQFYHWLDEKLNGQLLKILNWLVPVGYVMVVTVCFQQFLTHTLPMLSSPGLFRLFTIYFSMVLIYASTILAAFSDPGRITTINLKSYPYTPNQLIFFDGKTCSTCHIAKPARSKHCSVCNQCFLLYDHHCVWINNCVGYYNYKWFMLFLISNINMLGYGGWLCYWALTPVSWRKITSTNNANKVTGIFLILCSIFIVITTLFTFLHLRYIYLGVTTNELDKWSEIDHLVGLGVLYQIEPSIANENYVERAILDGNAVYISLKDERILIYNSNVKNFKLQLIQSVEDDLVNIYDHGFWNNLIERLKW
The following text describes a protein:
Function:
Part of a lipoate-protein ligase complex that catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. Can also use octanoate as substrate.
Miscellaneous:
MISCELLANEOUS: In contrast to E.coli, where the lipoate-protein ligase is encoded by a single gene product (LplA) with a large N-terminal domain and a small C-terminal domain, the same activity in T.acidophilum is dependent on two separate proteins, corresponding to the two domains of E.coli LplA, respectively.
Subcellular Localization:
Cytoplasm.
Sequence:
MEGRLLLLETPGNTRMSLAYDEAIYRSFQYGDKPILRFYRHDRSVIIGYFQVAEEEVDLDYMKKNGIMLARRYTGGGAVYHDLGDLNFSVVRSSDDMDITSMFRTMNEAVVNSLRILGLDARPGELNDVSIPVNKKTDIMAGEKKIMGAAGAMRKGAKLWHAAMLVHTDLDMLSAVLKVPDEKFRDKIAKSTRERVANVTDFVDVSIDEVRNALIRGFSETLHIDFREDTITEKEESLARELFDKKYSTEEWNMGLLRKEVV
The following text describes a protein:
Function:
Involved in the oxidative stress response and detoxification.
Sequence:
MAQFTLYTHKGGPNPWKAAMCLKELGLTYESVYLDFQKNEQKNPQHLKLNPNGRVPTLVDHLNNDYTIWESDAVLLYLTDRYDKQRAISLPHDHPDYHHELQYLFFQSSGQGVIWGQANWFNIYHPVPVPSAVTRYRNELKRVLGVLETILQDKPYLLGDKFTIADLSFVTWNNLLSMIFGKGKYEWDDQVPQLDFQKEFPKTYDWNHRINQRQAIAKTNEEKAKIGGH