lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
Sequence:
MSLEFDAFGNDVEEEEAVGPGSAASRPFDDGYLGYDPGLSSQRYEDYSSFAAGEDAKDPVDDNLPPASTGFPSDMSGGGGGEYGFHPVDAPVHHHHGGGGSMPDSPEGYGFSSAPSAFAMPEAEVKSYGAEENGEIFTSDGPILPEPDQMREEGFLLREWRRQNTMQLEEKERKEKERRNEIISEAEEYKRAFYEKRKLNCETNKTQNREREKLYLANQEKFHANADKQYWKAIAELVPHEIANIEKRRGKKEQDKKPSITVIQGPKPGKPTDLSRMRQLLVKLKHTPPPHMKPPPPPAPEPAKDAKDGAAAAAAAKQTSSPAKDANDGAAAAGKQPSSPAKDAKANGTTASPKEESPKLEEQADKAPAPTPDA
The following text describes a protein:
Function:
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MEMASFSRVYWGAATVLYVCIAYAFAKEVPQAYMDEIFHIPQCQAFCEGRFSYWDPMITTFPGLYYAALFLLSFLYPGTAAFQLLQGKFIRSTFRPLCSLFALRFVNIVLSLVCLLLFREVAFEVRLRAEHLLAVDSGSQELGSGQIAVTNGVESQSKKPIGSNDSKTYREANKGKETISRAGSGKLSVAKRRGTHHTENGTAAAIEDLTGRKTGPGGPGYEFGEAAYDSIGTASVGDLQNRRQPSTEDFFKAAALVLYPPHFFFAFLFYTDVGSTAAIAAMYLATLRHRFWVAALLAVVAIFFRQTNVVWALFVTCTGATEVLWPLPGSGMPSDRLDKRSLNKTESVSPLALWALAKRAWTHRTAVLRTFGPLLFVIAAFVVFAVRNGGIVLGAKDAHKMSLHMPQFLYCLAFVFCALAPVQLLPAHVSHVSAYGIARVKRSPGRTLALLLAALAAVHWFTIEHPYLLADNRHYPFYLWRWIFKRHVAVKYLLVPFYLYAATSLVLSLAKTQRPLWIFFYLMATFGVLVPAPLIEFRYFNVPFFLAALHVPMPSKRRRPTLLLQLVLFAILDIGAVSLFLRRTFEWPHESGTQRYMW
The following text describes a protein:
Function:
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells.
Sequence:
MEVPGSLCKKVKLSNNAQNWGMQRATNVTYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTVSMALEEYLVCHGIPCYTLDGDNIRQGLNKNLGFSPEDREENVRRIAEVAKLFADAGLVCITSFISPYTQDRNNARQIHEGASLPFFEVFVDAPLHVCEQRDVKGLYKKARAGEIKGFTGIDSEYEKPEAPELVLKTDSCDVNDCVQQVVELLQERDIVPVDASYEVKELYVPENKLHLAKTDAETLPALKINKVDMQWVQVLAEGWATPLNGFMREREYLQCLHFDCLLDGGVINLSVPIVLTATQEDKERLDGCTAFALMYEGRRVAILRNPEFFEHRKEERCARQWGTTCKNHPYIKMVMEQGDWLVGGDLQVLDRIYWNDGLDQYRFTPTELKQKFKDMNADAVFAFQLRNPVHNGHALLMQDTHKQLLDRGYRRPVLLLHPLGGWTKDDDVPLMWRMKQHAAVLEEGVLNPETTVVAIFPSPMMYAGPTEVQWHCRARMVAGANFYIVGRDPAGMPHPETGKDLYEPTHGAKVLTMAPGLITLEIVPFRVAAYNKKKKRMDYYDSEHHEDFEFISGTRMRKLAREGQKPPEGFMAPKAWTVLMEYYKSLEKA
The following text describes a protein:
Function:
Plays an important role in the reorganization of the actin cytoskeleton. Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. Regulates dendrite branching in Purkinje cells (By similarity). Regulates neuron morphogenesis and increases branching of axons and dendrites.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, ruffle. Cytoplasm. Cytoplasm, cytosol. Note=Recruited to the cell membrane via interaction with PACSIN1. Colocalizes with the actin cytoskeleton. Detected throughout the neuron cell body, as well as in axons and dendrites.
Sequence:
MKARAPPPPGKPAAQNVHSEQKLPHDATLGSQQSLVHLKEALHNSTLDITVVLPSGLEKQSVVSGSRAVMDLLVELCLQNHLNPSHHVLEIWSSETQQPLSFKPNTLIGSLNAHTVFLKEKVPEEKGKPGLTKAPEKSVRLVVNYLRTQKAVMRVSPEVPLQNILPVICAKCEVSPDHVVLLRDNIAGEELELSKSLNELGIKELYAWDNRREMLRKSSLGNDETDKEKKKFLGFFKVNKRSNSKAEHLGLSGADSDEDPSKSASGGDLNGCVTTPNSPSLHSRSLTLGPSLSLGNISGMSMKSDMKKRRAPPPPSPGLLGQDKVSEKASLSSQADLQKKKRRAPAPPPPQPPPPSPVVPNRKEDKEENRKSTVGMEENYETDTSSLTSSVNGVSNHSLQEAIIPDSGVDDIPVTFIGEVSDEPFDSGLFFSGSNNAAALNQGGIASQRSHLPPYQTEQSQPFIRTNRKEPDPSLPSQDYRKRNQPILANTSENENPVGIDPRVTSFVSKPSTDDPKAKDKDKMCGSGPSEKTQTGHRVNSLPVNPRVGEDENSNSALPPWSHHGQASGGSYGLKYGLTTYKIVPPKPEMRCYDRDVSLSTGAIKIDELGNLMSPHMNGSRTISKPSAVAETEAPPIGKVKEFWRRNSMEKYLNGPAECTVKKAPSTTITATSEKPQRDETKAGFTLTTPEQQPASQEYGAPPEEDRSRPHSAVSCPVKVPAPNPTDITFLKPQRRTSSQYVASAIAKKMGPPKVHADVVRPHKKTAEQGHEEAKLARPPPAWKDSAVPNLCSEAGQCEHGTNQGSVRLPSNPGGQLPADHPKVEVNSTYGKSATHNSPAAVHRNSYFLPGRSSQRDRVSVGQSCGFHEKQTISNQKMNSTSNPSQALDKAHPAPLLLTEARDSGRILVNGSAQTPGNCEPPHSQKESTLTSYIILQTEEKPSPLSADGQNSDDALPSSIFGPKKKFKPVVQRPLPKDISLHSALMEAIHTSGGRDKLRKTAEQASEGRPKKPSYVEAESERSALLAAIRGHSGTLSLRKVSSLASEELQSFRDAALMAPGVDKPQQEDRGLPPPPALPPPSTPASQVPSASIPVSRFSIGTLSNPVNARQALMDAIRSGTGAARLRKVPLLV
The following text describes a protein:
Function:
Probable carboxypeptidase.
Subcellular Localization:
Secreted.
Sequence:
MALSKFALCLWLCTSMFLLCTQIFSLELDPQTRALQEADRVISLPSQLPMQVLFRQYSGYVTVDKSNEKALFYWFFEATSKPAQKPLILWLNGGPGCSSVGSGAAQEIGPFLVKEGPTLKFNKYAWNKGMYLIVFTANLLFLDSPAGVGFSYSNKSLNVQGDNITALDSYAFLQNWFKRFPQYKSHEFYIAGESYAGHYVPQLADAIFDENKKSAKENYINLKGFIIGNPFLDYETDRRGMYDYAWGHGLISDALYQSIKAKCDFSSQILTQECWDQIFKYNSLYEMIDMFSLYTPTCALNAPSSSGKKLAARSNTVRVSGLFHMIPSAGHDPCTANYATEYFNRPDVQQALHANVTKVSRPYILCNSEVGNAWKNSTFSLLPTITKLINGGLRVWLFSGDTDGRLPVTSTRYTLNKLGLNIIEDWTPWYSHREVGGWTVTYEGLTFITVRGAGHQVPMFAPQQSLQIITHFLANKKLPSLAF
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLPRIGELFKERSLFITGASGFLGKVLVEKILYSVPDVKRIYIVVRSARGKSARERWTVITEGILFDRLRRESPDALQKVIVVEGDLMQENLGMSQHDIQRLCDEVSVVFHCAATVKFDEKLRDAVGMNVKGTTRLISLCHKMPKLACLVHCSTAYANCDRQKTEEMVYPAPVDPQKLNETLDWMDDKMIDVITPHLLGDRPNTYTLTKALAESQLMEDAQGLPVIIFRPSIVCAMWREQLPGWLDNVNGPAGLFIAVGKGVLSSMPGDLSAVADLIPVDVVANMMIATGAYRLNSSSTNIPIVHCTSGQLNPVTWNGVVSFLREVYKEYPIPDAFGIPSAIFYKNTTKFEFEHRLRHEFPAKALDIACQVVGKKAIYSRHYGKVRNMVHTLAYFTTRGWHFENKGLPMLWEALHPEDKKVFNFDVRQINWSNYLFDYVMGVRKYITKENLEDKKALAKAKTNIKNITLSSLQRAKFITRLVICYGLARLLSKYSKKYPFWKYFGAIFLTSQVIDNITYKPVHRLKSLDDYLKEQKAWIA
The following text describes a protein:
Function:
Required for the initiation of starch granules biosynthesis in leaf chloroplasts. Involved in determining starch granule number and size in chloroplasts.
Subcellular Localization:
Plastid, chloroplast. Note=Is in the soluble protein fraction of the leaves. Locates to distinct puncta within the chloroplasts.
Sequence:
MGFSQAIRLNLASFSSPSPCDYCLTRVVNHKQKSLVAFPSITRRKRHLLLSVQSVLHNTRPNINDNGSAESANVLFDKLFARTHRLERQTNQHSVYPDDDDLPYSNLGVLESDLEAALVALLKREEDLHDAERKLLSDKNKLNRAKEELEKREKTISEASLKHESLQEELKRANVELASQAREIEELKHKLRERDEERAALQSSLTLKEEELEKMRQEIANRSKEVSMAISEFESKSQLLSKANEVVKRQEGEIYALQRALEEKEEELEISKATKKLEQEKLRETEANLKKQTEEWLIAQDEVNKLKEETVKRLGEANETMEDFMKVKKLLTDVRFELISSREALVFSREQMEEKELLLEKQLEELEEQRKSVLSYMQSLRDAHTEVESERVKLRVVEAKNFALEREISVQKELLEDLREELQKEKPLLELAMHDISVIQDELYKKANAFQVSQNLLQEKESSLVEAKLEIQHLKSEQASLELLLQEKDEELAEARNKLGEVNQEVTELKALMISREDQLMEATEMLKEKDVHLHRIEGELGSSKLKVTEAEMVVERIAELTNRLLMSTTNGQNQNAMRINNEISIDSMQQPLEKPHDDYGMENKRLVMELSFTRENLRMKEMEVLAVQRALTFKDEEINVVMGRLEAKEQELKKLKEETINDSEDLKVLYALAQERVGEKTMGDLAIEMLQLEAANLEVEAATSALQKLAKMSTELLTQADMSIEADTTHTVMPERGYSEGSNECLGEVKTEVVRLWSLTEKLLENAGIVAGTSTCMEGVIL
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MLPGFGATQTVSPFPNPPEYASAYTSDRIDNGSAPPPPHPLTEFKVFGEEYRLEEDVIAPLSTAGVEQYYVDKNNWKAEMKKLNRXIGAFFDLLEVLIRAPDHPARDKKMVDLHTIFINMHHLINEFRPVQARDSVRILQERQIDELTEICDDFREYLAHGREVVEDQFKMITGKLPPPPPPSDLTRVRMQNGALHRLIEVEKETEEDEEMKEDDEEKPSTSSSEGNQKTLRDMTKGHGPPSVVNLLARQLNEMELKK
The following text describes a protein:
Function:
Histone methyltransferase.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MADLQRFLQDRCLGVSNLPQKGRSLFTARDFRPGEVILSQKPYICVPNNTSSESRCDGCFKTNNLKKCSACQVVWYCGSSCQKSEWKLHRDECKALTRLEKEKRKFVTPTIRLMVRLYIKRNLQNEKVLPITTTDNYSLVEALVSHMSEIDEKQMLLYAQMANLVNLILQFPSVDLREIAENFSKFSCNAHSICDSELRPQGIGLFPLVSIINHSCSPNAVLVFEEQMAVVRAMDNISKDSEITISYIETAGSTLTRQKSLKEQYLFHCQCARCSNFGKPHDIEESAILEGYRCANEKCTGFLLRDPEEKGFVCQKCLLLRSKEEVKKLASDLKTVSEKAPTSPSAEDKQAAIELYKTIEKLQVKLYHSFSIPLMRTREKLLKMLMDVEIWREALNYCRLIVPVYQRVYPATHPLIGLQFYTQGKLEWLLGETKEAVSSLIKAFDILRISHGISTPFMKELSAKLEEARAEASYKQLALH
The following text describes a protein:
Function:
Thylakoid-determinant subunit of high molecular weight LFNRs-containing protein complexes.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side. Plastid, chloroplast envelope. Plastid, chloroplast stroma.
Sequence:
MQTAASSVVGLSAVLPAAVKGRSLQIQAPRRVALRVRAAAAAVAVEAAEVDYSSNISVFPMEACDLIGGEACNVQMYPEAKLSSSAAVAVSRAAAEEVDRDYLSYDEPTTVFPEEACDDLGGEFCKAT
The following text describes a protein:
Function:
Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.
Subcellular Localization:
Cytoplasm.
Sequence:
MKQFKRGIERDGSGFVVLMAEEAEDMWHIYNLIRVGDVIKASTIRKVVSETSTGTTSSQRVHTMLTVSVESIDFDPGAQELHLKGRNIEENDIVKLGAYHTIDLEPNRKFTLQKTEWDSIDLERLNLSLDPAQAADVAAVVLHEGLANVCLITPAMTLTRAKIDMTIPRKRKGFTSQHEKGLEKFYEAVCVAFMRHVNLQVVKCVIIASRGFVKDAFMQHLIAYADANGKKFTADQKAKFMLTHSSSGFKHALKEVLETPQVAARLADTKAQGEVKALNQFLELMSTEPDRAFYGYNHVSRANQELAIETLLVADSLFRAQDIETRRKYVKLVESVREQNGKVHIFSSMHVSGEQLAQLTGCAAILRFPMPDLDDEPMSDDE
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits translation and colony formation. Its toxic effect on colony formation is neutralized by coexpression with cognate antitoxin VapB22; the effect on translation has not been tested but is probably neutralized also.
Subcellular Localization:
Secreted. Note=Following 6 weeks of nutrient starvation.
Sequence:
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSVAATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW
The following text describes a protein:
Function:
NAD-dependent deacetylase, which participates in a wide range of cellular events including chromosome silencing, chromosome segregation, DNA recombination and the determination of life span. Involved in transcriptional repression of the silent mating-type loci HML and HMR and telomeric silencing via its association with SIR3 and SIR4. Plays a central role in ribosomal DNA (rDNA) silencing via its association with the RENT complex, preventing hyperrecombination, and repressing transcription from foreign promoters, which contributes to extending life span. Probably represses transcription via the formation of heterochromatin structure, which involves the compaction of chromatin fiber into a more condensed form, although this complex in at least one case can still bind euchromatic levels of positive transcription regulators. Although it displays some NAD-dependent histone deacetylase activity on histone H3K9Ac and H3K14Ac and histone H4K16Ac in vitro, such activity is unclear in vivo and may not be essential.
Miscellaneous:
MISCELLANEOUS: Its stability is directly linked to life span, which is extended when it is present in high dosage. Conversely, its absence shortens life span; MISCELLANEOUS: The reported ADP-ribosyltransferase activity of sirtuins is likely some inefficient side reaction of the deacetylase activity and may not be physiologically relevant; MISCELLANEOUS: Present with 3350 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus. Note=Associated with nucleolar chromatin. Preferentially bound to the spacer regions of the rDNA repeats through its interaction with NET1.
Sequence:
MTIPHMKYAVSKTSENKVSNTVSPTQDKDAIRKQPDDIINNDEPSHKKIKVAQPDSLRETNTTDPLGHTKAALGEVASMELKPTNDMDPLAVSAASVVSMSNDVLKPETPKGPIIISKNPSNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQALIGTINSIVHINSQERVQDLGSAISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRLRLSNFFTIDHFIQKLHTARKILVLTGAGVSTSLGIPDFRSSEGFYSKIKHLGLDDPQDVFNYNIFMHDPSVFYNIANMVLPPEKIYSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKLVQCHGSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRREYFPEGYNNKVGVAASQGSMSERPPYILNSYGVLKPDITFFGEALPNKFHKSIREDILECDLLICIGTSLKVAPVSEIVNMVPSHVPQVLINRDPVKHAEFDLSLLGYCDDIAAMVAQKCGWTIPHKKWNDLKNKNFKCQEKDKGVYVVTSDEHPKTL
The following text describes a protein:
Function:
Transcription factor. Binds to the E box motif 5'-CACGTG-3', probably in a heterodimeric complex with mml-1. Involved in modulating longevity in response to TOR signaling, dietary restriction, the decline in protein homeostasis associated with normal aging, germline signaling and the insulin-like signaling pathway. Plays a role in autophagy. Involved in regulating migration of the ray 1 precursor cells in the male tail, acting in concert with Wnt and semaphorin signaling pathways. Regulates transcription of genes encoding extracellular matrix (ECM) components which may contribute to the substratum required for migration of the neighboring ray 1 precursor cells. Required for resistance to oxidative stress. Involved in promoting infection by the microsporidian pathogen N.parisii, probably acting independently of its canonical partner, mml-1.
Subcellular Localization:
Nucleus. Cytoplasm. Mitochondrion. Note=Only sporadic mitochondrial localization.
Sequence:
MSRSRSAAASSSQKPDDMDLMSPDGSASSPSAPNTPATNSGGFSSDRKKATHLRCERQRREAINSGYSDLKDLIPQTTTSLGCKTTNAAILFRACDFMSQLKTDISDADKQLAQLNAQAAALEMIASEYEQMASSVPDAGQSTIQVKMLQLLLDDCFTSFSSQVDFTTYATITRTLLSWVESLAPNAEPFKSTAGKMVTMPFTSP
The following text describes a protein:
Function:
Possible non-essential role in spermiogenesis.
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: May be due to a competing acceptor splice site; MISCELLANEOUS: [Isoform 5]: Due to an alternative splicing donor site in exon 19. Markedly reduced enzymatic activity.
Subcellular Localization:
[Isoform 1]: Cytoplasm; [Isoform 4]: Cytoplasm. Nucleus.
Sequence:
MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLPQLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKNTNVLPPIV
The following text describes a protein:
Function:
A non-essential division protein that localizes to the septal ring in low ionic strength medium; Localizes to the septal ring in about 30% of observed cells before cell constriction occurs; localization occurs in low ionic strength medium (0 NaCl) and requires FtsZ but not FtsEX. Overexpression partially restores correct FtsI localization to the division septum in an ftsEX deletion. Isolated as a multicopy suppressor of an ftsEX deletion mutant; it does not suppress other cell division defects (e.g. ftsA, ftsI, ftsQ or ftsZ).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Note=Localizes to the septal ring before constriction, only when cells are grown at low ionic strength.
Sequence:
MEYGSTKMEERLSRSPGGKLALWAFYTWCGYFVWAMARYIWVMSRIPDAPVSGFESDLGSTAGKWLGALVGFLFMALVGALLGSIAWYTRPRPARSRRYE
The following text describes a protein:
Function:
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MLLLDYQNVLIQNLLTERFSGGAPVSIDQVVSDFDGVTFHLSTPESKTKILISIHVKCFKELVQYGAQEVLEREYGPYIVTPEPGYDFSVQIDLENLPAEQEARDELIMRLALLKRNAMAAPFERAFDEFAKLSEEASRYTSESAPQGVKEGGELMAIHYREEEAIYIKASHDRVTVIFSTVFREETDRIFGKVFLQEFVDARRRVVTLQNAPQVLFRSDPPLELQGVPGLQTAGDGKMSYVTFVLFPRHLTPQRRYENISHIQTFRDYFHYHIKASKAYIHTRMRKRTADFLQVLNRARPENEERERKTASGRTFRVHG
The following text describes a protein:
Function:
Plays a role in modulating RNAi activity and P-granule accumulation in the germline. May function in association with CSR-1 complex components such as drh-3 to regulate RNA transcript accumulation in germ cells.
Subcellular Localization:
Cytoplasm. Cytoplasmic granule. Note=Mainly localizes to the rachis, which is the central core of the cytoplasm connecting developing oocytes in the syncytial gonad. Within the rachis, partially co-localizes with the P-body component cgh-1. Localizes to foci next to P-granules, but does not co-localize with P-granules.
Sequence:
MSNGKRGRKAKPTNKEKDMIFTPGCVDCHMNHLPFQCPRPVMTKKLPEWEKKSIGMGKLKNPLDSKVKMYSEPARQTTWKEKLSQLNHENMSYNAHNKRSSRQRGNSYRLPQQNIPPPSHHQSSQVMRGFQNAPFQMQPHYNNERKPQSRRNDTMRASKSAYAAATAPVKKHVRPANEQHMRKLNDLLRPFSYGSDDLYEETQPFVKETSLANVDIQICQTRPKVPPGKMWIFESRTIYDENGNCVSAREGAMEVSLASRMHNEPIVIVSMNDSMCF
The following text describes a protein:
Function:
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle, secretory vesicle, Cortical granule. Note=Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells.
Domain:
The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Sequence:
MAQRDADKYLYVDKNIINNPLTQADWAAKKLVWVPSEKSGFEAASLKEEVGDEAIVELAENGKKVKVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKSKKDQGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLSGAGEHLKTDLLLEPYNKYRFLSNGHVTIPGQQDKDMFQETMEAMRIMGIPDEEQIGLLKVISGVLQLGNIVFKKERNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQTKEQADFAIEALAKATYEQMFRWLVMRINKALDKTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQNEGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPKATDKSFVEKVVQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSSDKFVSELWKDVDRIVGLDQVAGMSETALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNAIPKGFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELIKVKEKQLAAENRLSEMETFQAQLMAEKMQLQEQLQAEAELCAEAEEIRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEDVIVLEDQNLKLAKEKKLLEDRMSEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSSDLHDQIAELQAQIAELKIQLSKKEEELQAALARVEEEAAQKNMALKKIRELESQITELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVTVLKKTLEDEAKTHEAQIQEMRQKHSQAIEELAEQLEQTKRVKANLEKAKQALESERAELSNEVKVLLQGKGDAEHKRKKVDAQLQELQVKFTEGERVKTELAERVNKLQVELDNVTGLLNQSDSKSIKLAKDFSALESQLQDTQELLQEETRLKLSFSTKLKQTEDEKNALKEQLEEEEEAKRNLEKQISVLQQQAVEARKKMDDGLGCLEIAEEAKKKLQKDLESLTQRYEEKIAAYDKLEKTKTRLQQELDDIAVDLDHQRQTVSNLEKKQKKFDQLLAEEKNISAKYAEERDRAEAEAREKETKALSLARALEEAIEQKAELERVNKQFRTEMEDLMSSKDDVGKSVHELEKAKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNQQAMKAQFDRDLLGRDEQNEEKRKQLIRQVREMEVELEDERKQRSIAVAARKKLELDLKDLESHIDTANKNRDEAIKHVRKLQAQMKDYMRELEDTRTSREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALAMEEKRRLEARIAQLEEELEEEQGNTEIINDRLKKANLQIDQMNADLNAERSNAQKNENARQQMERQNKELKLKLQEMESAVKSKYKATITALEAKIVQLEEQLDMETKERQAASKQVRRAEKKLKDILLQVDDERRNAEQFKDQADKANMRLKQLKRQLEEAEEEAQRANVRRKLQRELDDATETADAMNREVSSLKSKLRRGDLPFVVTRRLVRKGTGECSDEEVDGKAEAGDAKATE
The following text describes a protein:
Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Sequence:
MCGSYYGNYYGDHGYGCCGYEGLGYGYGSLRCGYSSCCGYGHGYGSRFFCGCGYGCGSGYYY
The following text describes a protein:
Function:
Asymmetrically hydrolyzes Ap4A to yield AMP and ATP.
Sequence:
MPKQLYFSKFPVGSQVFYRTKLSAAFVNLKPILPGHVLVIPQRAVPRLKDLTPSELTDLFTSVRKVQQVIEKVFSASASNIGIQDGVDAGQTVPHVHVHIIPRKKADFSENDLVYSELEKNEGNLASLYLTGNERYAGDERPPTSMRQAIPKDEDRKPRTLEEMEKEAQWLKGYFSEEQEKE
The following text describes a protein:
Function:
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Subcellular Localization:
Nucleus.
Sequence:
MQENIISANSSKVFVLPEKCMSNGRKCSIITLLHPRTQEKTKFLISSDENKTELFELNQYTDEFSSWFINNETVKSDGTVYIVTPMDPLFMCLPSLCANAREKFVPLDQIFSTENGEEVLGKVFEHSALNVKQLDNVCDSKSCVDLLAYRYNETKTLEWLKVKVERTVDALKSADLFIGDTEGDAYTRYAYGLICENIHADLAKKLATHLKIPERIEKRKSSGNQPSAKKVKTEASEDYSKLVKSPTNSENKNLTRAQKALKKVDKSGMKNISSFFGAKPKKK
The following text describes a protein:
Function:
Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.
Miscellaneous:
MISCELLANEOUS: Present with 2830 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSTADQEQPKVVEATPEDGTASSQKSTINAENENTKQNQSMEPQETSKGTSNDTKDPDNGEKNEEAAIDENSNVEAAERKRKHISTDFSDDDLEKEEHNDQSLQPTVENRASKDRDSSATPSSRQELEEKLDRILKKPKVRRTRRDEDDLEQYLDEKILRLKDEMNIAAQLDIDTLNKRIETGDTSLIAMQKVKLLPKVVSVLSKANLADTILDNNLLQSVRIWLEPLPDGSLPSFEIQKSLFAALNDLPVKTEHLKESGLGRVVIFYTKSKRVEAQLARLAEKLIAEWTRPIIGASDNYRDKRIMQLEFDSEKLRKKSVMDSAKNRKKKSKSGEDPTSRGSSVQTLYEQAAARRNRAAAPAQTTTDYKYAPVSNLSAVPTNARAVGVGSTLNNSEMYKRLTSRLNKKHK
The following text describes a protein:
Function:
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSINNNSVNNSNVTTSNNNTENDNNSRSKSGILNDRYINFKIFKKGEELSDEQKAFIKVQTYLNEGILPKCIGMGIGGGIVGLLIGVFFFSMQPSNIDYNLTYKQQLKEQFSLLKQSVKSSCLNFAKIGFLYSFYENSLQKIRATNDLTNTLYSGCLTGASISYKKGVPSMISGCASFAAFSLAIEKWQRSTR