lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway.
Sequence:
MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPAKSVK
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
Sequence:
MATTLAKRPKLSGLGESPGAPSAAPFSSPYSPISLTFTLNVISCGFCKEVLVSCIYQCRNHHLVCAHCRNTERRWCSCPGTVESFRNEALERLVGCFSVLCSNSSFGCPDAFPIYARRAHEARCSFAPRRCASCSFTGAASQFSSHFSDHHRWNIIDIPDYNVEFGMALKGSEARVIPVRIGSSEAMFLIHFEQQGSSGRLYPSEVARHQENVKTTVIFLMDAYGPRFASSAARTALAYSIERRETLPFMANGSIYDNNSRHTVRNVHGIVCALSWGILIPLVIRWYGFVTRLQVQGRHLKLFYAVRIIAYTLGFGGTIVGLWLAGDAGEIGNKAHFSIAIALLVLGGIGAIGFQCYCCCPVDGVAWAVMIMGIVNVFKGFDMLDPPRGYRIAYTVVLSLGCVAGVAAEILISKLEIILGLYMPPKRKETEHPSLEAAVEAAHRAAHNGDERGDDRNVGDSPHAVRPEDPESTKHIGDGENHDDETKDFDAPHPMFDSHQVEKCHRQQRDRDAEVGFVVGDAAVRDHARPEPDRRRGRGDGVERRLEKDVRSRQGTGQEILPVDEHWDEDPP
The following text describes a protein:
Function:
Critical regulator of mitochondrial DNA (mtDNA) abundance. Binds dsDNA throughout the mitochondrial genome without sequence specificity and controls mtDNA copy number by promoting its replication (By similarity). Also plays important roles in mitochondrial metabolism and cell proliferation (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass type I membrane protein. Mitochondrion matrix, mitochondrion nucleoid. Note=Retained in nucleoids under mtDNA replication stress caused by ddC and EtBr.
Sequence:
MGAAEPRMEVCPYCKKPFKRLKSHLPHCKMRGPSISADQNVSQSKPAALAQKEKSPTRDLTRAKEKELEVDRPKRAVKAETSRASWTAAASPLPEGILGSVRITKAEGENKDQNQFSFQALSQAKPEVTLQRVTTPWSPASDATSPKRELTQDVSESKGSPCPSETEAPSLVSSVEPFLANQDRKYSSTQPHANPATSVGLKLGTVDPQRQKLRVKLLDVPLSDRHSPKSGSHGVQRVTPSVLSREEGSQDGGHLLGVSAHPGNTKTQKSESLLLGLHTGLLGKAPVREHQELGLGMELSQSKGNTENRMSVTNVQEGAGLGQGGKDPITATKAKPHTALELRNVFMPESGNQSLTSPAVTSTPEENAQFCGQSHVPAITLSVGSVRDVLEPTSFYQPHTAQAGHCLMSYSAQYPVPKTFVGHVAAVTSGAPPRSVGLEWFPELYPAYVGLGVLPRRPPPWSLAAQVPPLPTLQGRSVSKVPWWGRSSADSRSLEPLTLTTSSLPLMRLLGAVHKGWVQCNTTIKKSGVGGLTMLFAGYFILCCNWSFKHLKLQHWRK
The following text describes a protein:
Function:
Proteolytically removes the C-terminal three residues of farnesylated proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGDAGREAYLRGRAALLLDSVSLGDLPSTAAGVFFKIFQRRVYKTTTHVPLELGQIMDSETFEKSRLYQLDKSTFSFWSGLYSEVEGTLILLFGGIPYLWRVSGRFCGYAGFGPEYEITQSLVFLLLATLFSALTGLPWSLYNTFVIEEKHGFNQQTLGFFMKDAIKKFVVTQCILLPVSSLLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYADYIAPLFDKFTPLPEGKLKQEIEVMAKSIDFPLTKVYVVEGSKRSSHSNAYFYGFFKNKRIVLFDTLLEEYSVLNKDIQEESGMEPRNDGEGDSEEIKAKVKNKKQGCKNEEVLAVLGHELGHWKLGHTVKNIIISQMNSFLCFFLFAVLIGRKELFVAFGFNDSQPTLIGLLIIFQFIFSPYNEVLSFCLTVLSRRFEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFSMWHYSHPPLLERLQALKNSKQD
The following text describes a protein:
Function:
Catalyzes the oxidation of (S)-lactate (L-lactate) to pyruvate with subsequent transfer of electrons to cytochrome c. Is involved in the utilization of (S)-lactate as a sole source of carbon for growth. Can also use ferricyanide as an electron acceptor in vitro.
Miscellaneous:
MISCELLANEOUS: Present with 4590 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion intermembrane space.
Domain:
Consists of two discrete domains, an N-terminal cytochrome b domain from residues 81 to 179 and a C-terminal flavin-binding domain from residues 180 to 566. In addition there is an extended C-terminal tail. The cytochrome b domain is required for efficient cytochrome c reduction.
Sequence:
MLKYKPLLKISKNCEAAILRASKTRLNTIRAYGSTVPKSKSFEQDSRKRTQSWTALRVGAILAATSSVAYLNWHNGQIDNEPKLDMNKQKISPAEVAKHNKPDDCWVVINGYVYDLTRFLPNHPGGQDVIKFNAGKDVTAIFEPLHAPNVIDKYIAPEKKLGPLQGSMPPELVCPPYAPGETKEDIARKEQLKSLLPPLDNIINLYDFEYLASQTLTKQAWAYYSSGANDEVTHRENHNAYHRIFFKPKILVDVRKVDISTDMLGSHVDVPFYVSATALCKLGNPLEGEKDVARGCGQGVTKVPQMISTLASCSPEEIIEAAPSDKQIQWYQLYVNSDRKITDDLVKNVEKLGVKALFVTVDAPSLGQREKDMKLKFSNTKAGPKAMKKTNVEESQGASRALSKFIDPSLTWKDIEELKKKTKLPIVIKGVQRTEDVIKAAEIGVSGVVLSNHGGRQLDFSRAPIEVLAETMPILEQRNLKDKLEVFVDGGVRRGTDVLKALCLGAKGVGLGRPFLYANSCYGRNGVEKAIEILRDEIEMSMRLLGVTSIAELKPDLLDLSTLKARTVGVPNDVLYNEVYEGPTLTEFEDA
The following text describes a protein:
Function:
Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MAEIEENTVFEINDFTIVTDMEHFGAAFEGILQKYEFSSRRPCLSNDVKYRLIVTDTNMISIGENKLRIELLQPVPASSNPSNDVEFVEAPKDEIEEDAHVIPFTVAEEVANLKHGFEVTDSFLLKFGIRECIIISPNDSSGTFTDENQVNTVMGNIKTILHSSRCEVPVFCYIKDQSLDMISGYASDGNSTYNFSSVVLRNINRRHCSMTDLLYLFKEHLGASISAFHEEVRMSSRFTHVVPLKQSKYFRNHTVETFGLLATGPTSSLPFDILEIAATWRFFRENSLTENHSHSDFDINYSSYWNIKMKSTKSSLLGVLDEILGVYREDTRKAIRSDLNCALILGKHYTQKELPNAFQKLTINSASEVKIGKHAETEDSGTNGPMPPALMKSWVNFIFNEAESDNESLAHELNMLNAASMSENQLSDDELVNNVKLDTLFNYKNPKSANTFLAPYKCAKKSTVTWRLAIALANARVFMSDQPRAEPQLWVEFLLKLREKYEKMETVEKVYNGIDHLQCSFSQKMQMLQLCIDARQKRHRMLDSAHSANNSDEFFDANESFNAETILEPNNEGRLKLFGLNLVEIPDVPMYIPVTQDACPLTDEMIDARNEHLFSLDEEDRVHLQMELVKSDMQSFKAANAGAVFADFLRWHSPKDYDEKTNTISERMLISNNVWVRSWEAALPIPVANQARIFNDTKIAEEILEIFNNATLDQVREWMKPTVFAATLERLTEIESSYGVSEEKQKQRTKTAKILANATLNNTPMDYNEISKYCSQIEMIHNMKVHLMQLFENAREKMHPPYPSETDVQSAIKQLVNIAVHNLWDNSTDEEPTFVIKPQDPIGRAIAVIGKLDELTEQQLINGHRKEYIFNWKHSCPSTTTIPMTHRMYADLRSDKHSLYFSMANDCNFSNSSYL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that acts as a repressor of photomorphogenesis and as an activator of etiolation in darkness. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Represses photomorphogenesis in darkness by mediating ubiquitination and subsequent proteasomal degradation of light-induced transcription factors such as HY5, HYH and LAF1. Down-regulates MYB21, probably via ubiquitination process. Light stimuli abrogate the repression of photomorphogenesis, possibly due to its localization to the cytoplasm. Could play a role in switching between skotomorphogenetic and photomorphogenetic pathways. Mediates the ubiquitination-dependent degradation of HY5 in the darkness during seedling development (e.g. hypocotyl growth). Represses CIP7 in darkness. Triggers ubiquitination and subsequent protein degradation of UNE10/PIF8, PCH1 and PCHL in the dark.
Miscellaneous:
MISCELLANEOUS: Plants lacking COP1 are not viable; MISCELLANEOUS: Although plants lack TRIB proteins, a human TRIB1 peptide binds to a highly conserved surface on the top face of the beta propeller, indicating a general mode for recognition of peptide motifs by COP1.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localizes to the nucleus in darkness but is gradually relocated to the cytoplasm upon illumination. Localizes to subnuclear foci (speckle) and in dispersed nuclear localization in the dark.
Domain:
The coiled-coil domain (134-201) is necessary for SPA1, SPA3 or SPA4 binding. The DWD box is required for interaction with DDB1A.
Sequence:
MEEISTDPVVPAVKPDPRTSSVGEGANRHENDDGGSGGSEIGAPDLDKDLLCPICMQIIKDAFLTACGHSFCYMCIITHLRNKSDCPCCSQHLTNNQLYPNFLLDKLLKKTSARHVSKTASPLDQFREALQRGCDVSIKEVDNLLTLLAERKRKMEQEEAERNMQILLDFLHCLRKQKVDELNEVQTDLQYIKEDINAVERHRIDLYRARDRYSVKLRMLGDDPSTRNAWPHEKNQIGFNSNSLSIRGGNFVGNYQNKKVEGKAQGSSHGLPKKDALSGSDSQSLNQSTVSMARKKRIHAQFNDLQECYLQKRRQLADQPNSKQENDKSVVRREGYSNGLADFQSVLTTFTRYSRLRVIAEIRHGDIFHSANIVSSIEFDRDDELFATAGVSRCIKVFDFSSVVNEPADMQCPIVEMSTRSKLSCLSWNKHEKNHIASSDYEGIVTVWDVTTRQSLMEYEEHEKRAWSVDFSRTEPSMLVSGSDDCKVKVWCTRQEASVINIDMKANICCVKYNPGSSNYIAVGSADHHIHYYDLRNISQPLHVFSGHKKAVSYVKFLSNNELASASTDSTLRLWDVKDNLPVRTFRGHTNEKNFVGLTVNSEYLACGSETNEVYVYHKEITRPVTSHRFGSPDMDDAEEEAGSYFISAVCWKSDSPTMLTANSQGTIKVLVLAA
The following text describes a protein:
Function:
Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MTSSPALSEAPAAPKAVRPSSASGTSTKAAGASTKTKKTTSKTAAAAAPPAKPSRATSAAGLPLPALVAGGVGALGLVALAAWALVSGRRRGGSSSSSKDGKDGGKDSAVKGPCSKLKPTSRCVPLADGSGCVVRREIPADNSCLFNSIGYVMHRSKTRAPHLRNVVAQQVSGDRNTYSDAFLGMSNESYCAWIRQPYNWGGGIELAILAQAYGIEIAAWNIESKKEHVFGEESGYKRQVMVIYNGVHYDALAVCAHPRANADEDELNYNPRGKRGKMIIAAARKLVELAHKESAFNGAAEKKAAAAAAAAAKKAAAAAAKTNGTTAASTGAGSGASSATANSTSGSSSNGGSGTAGGAKTASGAKSSKPRVARSAAAASTAAGAAKADGAPTAASGSGAGAGAVGAGLSGGTKLSCGDCGVMLDGPAAAQQHAHSTGHVNFSEVAAA
The following text describes a protein:
Function:
Catalyzes the transfer of a phosphate from ATP to alpha-D-galactose and participates in the first committed step in the catabolism of galactose.
Sequence:
MTSHGGRALGPRRTFGKPRSAPLRLRVGAGPARVGSTDRAPPRKASPDPAVPPAPLEGAPAGLARSPPPGRGGGVGGAGTRRRAPGRWLGRGRGGAGRRGRGRGRGRGARSGMCAAPARPRPEHPAPTGPRCRASVMAASSPPRAGELLAEARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELVTVLVGSPRADGLVSLLTTSEDADEPRRLQFPLPTAQRSLEPGTPRWANYVKGVIQHYPAAPLPGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQLCPDSGSVAARAQVCQQAEHSFAGVPCGIMDQLIALLGQEGHALLIDCRSLETSLVPLSEPKLAVLITNSNVRHSLGSSEYPLRRRQCEEVARALGKESLREVQLEELEAGRELVSKEGFRRARHVVGEIRRTAQAAAALCRGDYRAFGRLMVESHHSLRDDYEVSCPELDQLVEAALSAPGVYGSRMTGGGFGGCTVTLLEASFTSQVMQHIQEQYSGTATFYLSQAADGAKVLHW
The following text describes a protein:
Function:
Acts in the GPI biosynthetic pathway between GlcNAc-PI synthesis and GPI transfer to protein.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTSASPSPLRAANAASSAPVPPPAMKPSAPPVNILPTQLARTYSFVHPAALLAILATRFQALVADPVAEMLNTLPFLALLQVTYVMVCLPPAGSVLPSPPASPVSDGDEKEKEKEKEKEKEKEKRKLPLRAGKLPRKKNQTHAAGLSAKLTPALLSLILTFLLATPVLSLLLVLFGAPLTTHNAETVLCAAHMALLASTALIYVHGVDGAVWREVWAFARPADAVWGGALGTALGAWFGAVPIPLDWDRPWQAFPITILTGAYFGFAVGSVVCRSSWLFGKWLEFTPEQDDRDKKTE
The following text describes a protein:
Function:
Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
Subcellular Localization:
Nucleus.
Sequence:
MSSSDSTARQELGDRFGRAVMDHPDVMAECLSLMRLYNLTASDLFFKYEAFVMSRPSGLRAKLSTITINSVKELRTELQRSQQAKAVANMGAANVPRLNGSEKKAAVGVKKAKGLGDLEGLLGNLTTPNRPTKPRPSASSTISPSHFASPASTVKATPSHLTTPQRQSPLPPTASSYRPNPSKLASSNNVFLDTPMDKGGNGLLVPSSPLSPSGVSPSSSPQPSQSFTKQANSNTVVETLNIHLPQLPPSHTRLTSKPRVELSSTITAADYNYRYMFEKLSERSEALDDSIDEYADAIKDAYGLSELGDPHFVSDESIYTVGRVLSNTTSSKSDKTALKNSFHLQSSRLIGAGKRIALELPEEKLKVRGGAPGVKGFSLYSGCLVCVKGRNGGGSKFVVEEVLLLPPSLLPQTPASELIDFQYGDKLKGEPLSLMVAAGPYTLNENLLFEPFETLVDKVLEDRPDVLILLGPFVDSQHPIIKSCAVTETPQEIFRKQISSRLQKVVTQSPSTVIILIPSVRDVVSHHMAFPQSMLEKEYLGLPKKVKALPNPCTFSVNEVTISLSSVDILFHLGQAHAPIRAQEADADPGMSGSPAPDPLANHIRQVLGQRSFYPLFPPQEDVAGEVNLDVTHYPLLKMDQAPDILILPSRLNKFVKIVDSTLVINPSHIARARATGHYAKVIIHPTAREVLEESMEVDGEESLCEHQVYERARSEIWKI
The following text describes a protein:
Function:
Light-emitting reaction in luminous bacteria. The specific role of the beta subunit is unknown, but it is absolutely required for bioluminescence activity.
Sequence:
MKFGLFFLNFQKDGITSEETLDNMVKTVTLIDSTKYHFNTAFVNEHHFSKNGIVGAPITAAGFLLGLTNKLHIGSLNQVITTHHPVRVAEEASLLDQMSEGRFILGFSDCESDFEMEFFRRHISSRQQQFEACYEIINDALTTGYCHPQNDFYDFPKVSINPHCYSENGPKQYVSATSKEVVMWAAKKALPLTFKWEDNLETKERYAILYNKTAQQYGIDISDVDHQLTVIANLNADRSTAQEEVREYLKDYITETYPQMDRDEKINCIIEENAVGSHDDYYESTKLAVEKTGSKNILLSFESMSDIKDVKDIIDMLNQKIEMNLP
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in lipopolysaccharide biosynthesis and pathogenicity.
Sequence:
MHADTLDAMLHHELPHAAAGCQQAYGRIVTACQNTVTAIALAITRDVAASEDIAQEAFLRAWQRLAQLHQPASFLPWLRQITRNLARDWLRSHRHRPLSGEAADLAIAMAADPSPSPAEQALQVEEERAALEIMSALPNDSREILLLYYREGQRSQQVASLLGLSDAAVRKRLSRARATVRNELLQRFDTFARGSAPGVAFATTVTAATMLAAPGTASAAIALGGIGSLGGVGKLGASGLSGSALTSGSAAGALSVLLGMPMAIALLAITGVTLTTYMSGAYLLRFATTAREAAAIRGFTRLSTLTAALTCGAPLLLRAFGAPKWLALCVLAVGMSVVCYHTLGTLPRIMQPMLERDARRRGTTRPPLLYRCMFSRSAIAVSLAAVIVPIAYRYGVLGLV
The following text describes a protein:
Function:
Transcription factor that activates a subset of organizer-specific genes. Binds to the distal element (DE) of the gsc promoter to regulate its expression. In the presence of pou5f1.1/oct-25, forms a repression complex on the promoter of the gsc and mix2 genes to inhibit their transcription.
Subcellular Localization:
Nucleus.
Sequence:
MALAGKQYEGSLNNSRPNLWPSSIPGGKNEIITSLVTALDSMCTALSKLNTEVACIALHEESAFVVGTEKGRCFLNSRKELQADFQRFCIGAHKKDQENEVKRRNRDGIQNIQHVPLGPTSDIYLLRKMVEEIFEVLYSEALGKSNIVPVPYVKVMKEPGSVVVLGLPDGISFRKPAEYDLKSLMLILKHSHNIRFKLRIPTEESIREPKSCSELNSPPTSATKVIPETSQCHRLPIQEHPSSASNFPYSVSQPNQISLEPKQEVHSNMLGTNAVNQMLVQRPSAENNHDLSDCCGQQSPVAGSSLRQNVLASKHLLFSIVHDKTDKWDSFLRETEDINILRECVQILFNSRYAGALGLDHMVPVPYRKIACHPEAVEINGFPDKIPFKRPCTYGVPKLKRILEERHNIHFTIKSMFDQRIFDGTTFTKETTKSDSSSLGEEACSENQKAAALDMLGFPTGSRSEKSSISDECEPGTSSETTGVKLIKLEAEDPDIMQIAVPGTSSETSGVKIIKLESEDPDLIQITVPGTSNETSGVKPKLESEDPDLIQIAVPDRLAECVKNHLAPEDPSYVLDTGKVCDDRPCGVLRNENKHLDGIGDIIRQLRKHVENLFNRKYAKAIGASGPVKVPYAKFLMYPEDLFVLGLPEGVAFRRPNCFGITKLRRILEYSDGIQFVVKRPELISEGLEDCVVGSPGTLGFNDKSNEVILDETNTRPSFQESFDARLSRIDIANTLREQVQVLFNKKYGEALGIKYPVQVPYKRIKNNPGSVIIEGLPPGIPFRKPCTFGSQNLERILAVADKIRFTVTRPFQGLIPRPDDEDANRLGEKVILREQVKELFNEKYGKALGLDQPALIPYKLIRDNPDAVEVRGMPNDIPFRNPNSYDLHRLENILKAQDQIQMVVIKQLEPFPEICSEPPKIKNGNTGPKRKRKRVSEGNSISSASSNCSSSSSSSSNMDPISSAHHVSLVQWPMYMLDYGGLNMQLPGPINY
The following text describes a protein:
Function:
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
Sequence:
MDPPAIEHPRFAKPQRVAFVQACWHRDVVEEARIAFMKEAEARHLTHVDVFEVPGSFEIPLHAQILAKTRRYTAIVAAGLVVDGGIYRHEFVADTVIKALMDVQLRTEVPVFSAVLTPQQFHETEVHYDFFRRHFAIKGVEVAEACANTLLGLERLRGQVAAGIA
The following text describes a protein:
Function:
Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.
Sequence:
MEQDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEIDEDRIPNPHLKSTLAMSPRQRKKMTRITPTMKELQMMVEHHLGQQQQGEEPEGAAESTGTQESRPPGIPDTEVESRLGTSGTAKKPAESIPKTQQRGSKEPSTKEPSTHIPPLDSKGANSV
The following text describes a protein:
Function:
Kills sensitive strains of yeast.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPRFAIIFALLIAYSLFLSTLFTGSIPDRANTVTSNAPCQVVIWDWIRTRRICNCCSRLCYSLLGRSNLSRTAKRGVCTIAGAVLATAAVIVAAVLVGKSSGSATKRGLTKTISVLNHTIPFTDHILNGQTLSNGTGSNFVTIGFSGYAVHATIKRASTTDIISWVIPESMEPTLARVASYVSSSSINLAAVPDTGGNASALSFQNAVQEFATSWVSMTYDQSYGDLRNVANDEGGEEILILMRKRSYRISFQVIETGSTALLLRTRRVVSQLITMTYLVTVQARVGIQIGDIFQHYGGIDNYVMTSISVLRTLEDKAFHENKLLIVREPPNKSNQDANQSYRLRPFSANDLIQNLKSVDIGFLAFCSFFDKYAHYPEIIMMKITIFISKGNLWSIIYVIQARYVRKRVMKVRGQMPGGLLTNMESLLNIVSTPNLNISEFHIQTHSMSQSKPMYFQKQCYSSQNNIIYIYNSIHITCGAVYVIVHDVRTPSVFVLIELRNCKPLKNSWCETTKTSPRDTKIKKNEYNETVCRRAGALLDGRVRTIRFLMMRTHWSRVKGVSCNTANRLSRFCNHVVSYYPSQNATIHLLPTSLRAESLEQQYTTRPLSSSNNRFCCLKSIFINNCKKACESPSLVSCNLQQTAELLMVYYLYICEACYVSRNHDLLSKQCMSTVRAVYVARMRLPKFRSTFPCMPRLCWLVNGVVVV
The following text describes a protein:
Function:
A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Subcellular Localization:
Cell junction, desmosome. Cell membrane; Single-pass type I membrane protein.
Sequence:
MAKLLFFVICLQVTTSCVESCHLPGSVYVLVPQNIPVGYQITKVQTSDCDPKTLRLTLKDPSFSIRENGEVVAAAAVSLPDGERTFSVKAQDQNGPESAMEVYLYCKRAQQTDFKGQALLKRTKRRWQPPPTQILENDPGPFPKDVETLASDSASVHDVYYTISGPGADLDPKGVFSLNRDTGLLQVHKSLDREEIEEYKFRISAFKKATDEPADDPMTFVIRVDDKNDNPPEFVGKLQFTVSEQTPGAVVGKVNSTDKDKQDTDHVRIKYSLKSELNLFSIDPDTGEIRTITNTLDREVKDKYTVIIELRDLKGAPKGLSTTGTATITLSDINDNAPTFRKTSYEATIKENESGKCILDIPLDDKDLENTPNWISKLVITKGNENGNFQVERDPKQNIGRLCVVKPLDYEKTKSINLEVSARNEPDLIGTSAQWQSVPIVVSVSDVDEGPEFSAPTIRIPVKENTPNGSVIGSYTALDPETKSSSGIRYYKVQDPASWINVDTNTGELKVANTIDRESHYVYDGLYNITMRAVDPSLKTGTGTVILVIEDVNDNMPVFPSQLVMCENKDQSLSSMLVTAEDRDQAPFSSPFTFSLANENEEDWSIERFNDTTAMLKQLKDLPRGRYEIPLIVRDQQSFGKTQTVTATLCVCTKQGVCQANQSSISLGPLGILALLLPLFLLLLLFLLLAFVCSTRTEKVPFDETGYSGGILLESNTEAPGDEVDTFIPVASLGAGQQQLKESSKIFDSTWKGNKSGSTLGGHSIRENGFYQTGMNSINMQYGSGQFETQNYLGNGMSLERHYATDSSLTQFWRTNEHRINQKLAIMGEEGEEHFADDNVKCYGYEGVGSAAGSVGSCKDFGEEENLDFLNTLGPRFKTLAAVCKKT
The following text describes a protein:
Function:
Component of the translocation and assembly module (TAM), which facilitates the insertion and assembly of specific beta-barrel proteins into the outer membrane.
Subcellular Localization:
Cell outer membrane.
Sequence:
MKKKSLKLTALFLALSCFPAFAEQTVDIEVQGIRGFRAVRNTDLNVNLINKEEMDGSERYQHLVTKAVDRGLRVFGYYESSVRFERKQRQGKRDLLIAHVTPGEPTKIAGTDVQIEGEAAQDENFNALRKNLPKDGVLVEHQTYDDYKTAISRLALNRGYFDGNFKISRLEISPETHQAWWRMLFDSGVRYHYGNITFSHSQIRDDYLNNILNIKSGDPYLMNNLSDLTSDFPSSNWFSSVLVQPNVNHKSKTVDVEIILYPRKKNAMELGVGFSTDGGVHGQIGWTKPWINSRGHSLRSNLYLSAPKQTLEATYRMPLLKNPLNYYYDFAVGWEGEKENDTNTRVLTLSALRYWNNAHGWQYFGGLRMRYDSFTQADITDKTLLLYPTVGFTRTRLRGGSFATWGDVQKITFDLSKRIWLSESSFIKVQASSAWVRTYAENHRVVARAEIGYLHTKGIEKIPPTLRFFAGGDRSVRGYGYKKIAPKNRNGKLVGGSRLLTTSLEYQYQVYPNWWAATFADSGLAADNYTAKELRYGTGVGVRWASPVGAIKFDIATPIRDKDNSKNIQFYIGLGTEI
The following text describes a protein:
Function:
Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MVEYKPNQTVYAYHGPLIYEAKILKLKNGKDSFIINQDFQHEPLEEKPNSSGNHHHHHHSQHIAKFDPKKWQDQTCYYLHYQGWNSKWDEWVGIDRIMEYNEENKFKKLELDQLTKKKKAINNNEIIVNATTKNHTNNKNKKESNKRKSSSATTTSGVTAGTNNNKKQKSASTSTTNNTSGNSGTTSNKSKQILSRLNLNFPPELKHILVNDWEYITKDRKLVSLPSQYPINQILQDYKTYRTKQLTSNSDQLSILIEILTGLEIYFNKSLSLILLYKYEHLQYLNFLKQNIINPQQDILQSNIYGVEHLLRLIISFPGLLSTTTMDGISLSVLISELESLCRFIGDRLQLYQNNYEFTSPQYDSLARS
The following text describes a protein:
Function:
Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage.
Miscellaneous:
MISCELLANEOUS: Antibodies against PHF20 are present in sera from patients with hepatocellular carcinoma, glioblastoma and childhood medulloblastula.
Subcellular Localization:
Nucleus.
Domain:
The Tudor domain 2 mediates reading of dimethyl-lysine residues; The Tudor domain 1 doesn't bind dimethyl-lysine residues, due to an atypical and occluded aromatic cage.
Sequence:
MTKHPPNRRGISFEVGAQLEARDRLKNWYPAHIEDIDYEEGKVLIHFKRWNHRYDEWFCWDSPYLRPLEKIQLRKEGLHEEDGSSEFQINEQVLACWSDCRFYPAKVTAVNKDGTYTVKFYDGVVQTVKHIHVKAFSKDQNIVGNARPKETDHKSLSSSPDKREKFKEQRKATVNVKKDKEDKPLKTEKRPKQPDKEGKLICSEKGKVSEKSLPKNEKEDKENISENDREYSGDAQVDKKPENDIVKSPQENLREPKRKRGRPPSIAPTAVDSNSQTLQPITLELRRRKISKGCEVPLKRPRLDKNSSQEKSKNYSENTDKDLSRRRSSRLSTNGTHEILDPDLVVSDLVDTDPLQDTLSSTKESEEGQLKSALEAGQVSSALTCHSFGDGSGAAGLELNCPSMGENTMKTEPTSPLVELQEISTVEVTNTFKKTDDFGSSNAPAVDLDHKFRCKVVDCLKFFRKAKLLHYHMKYFHGMEKSLEPEESPGKRHVQTRGPSASDKPSQETLTRKRVSASSPTTKDKEKNKEKKFKEFVRVKPKKKKKKKKKTKPECPCSEEISDTSQEPSPPKAFAVTRCGSSHKPGVHMSPQLHGPESGHHKGKVKALEEDNLSESSSESFLWSDDEYGQDVDVTTNPDEELDGDDRYDFEVVRCICEVQEENDFMIQCEECQCWQHGVCMGLLEENVPEKYTCYVCQDPPGQRPGFKYWYDKEWLSRGHMHGLAFLEENYSHQNAKKIVATHQLLGDVQRVIEVLHGLQLKMSILQSREHPDLPLWCQPWKQHSGEGRSHFRNIPVTDTRSKEEAPSYRTLNGAVEKPRPLALPLPRSVEESYITSEHCYQKPRAYYPAVEQKLVVETRGSALDDAVNPLHENGDDSLSPRLGWPLDQDRSKGDSDPKPGSPKVKEYVSKKALPEEAPARKLLDRGGEGLLSSQHQWQFNLLTHVESLQDEVTHRMDSIEKELDVLESWLDYTGELEPPEPLARLPQLKHCIKQLLMDLGKVQQIALCCST
The following text describes a protein:
Function:
Acyltransferase involved in the biosynthesis of akuammilan monoterpene indole alkaloids (MIAs) natural products, components with various biological properties such as antidiabetic, antibacterial, anti-inflammatory, anticancer, and antimalarial activities. Catalyzes the conversion of rhazimol to akuammiline.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNITILSKETIKPLAPTPHHHKYYKVSLLDQFAPSSYMPFIFFYPNKFADRDAAGILTQLKESLSQILTIYYPLAGRVKDTVYVECNDEGVEFIEAQANGSLSDFLKQPDIAALNNFLPRNGNGLEKGCSISPVAIKATVFECSGIVLGVCIFHKVVDAAAAGEFLQSWAKIGRGSKETVELPNFTSASSLFPPRESLSSKFVRDFDNFFFQGSKSFMRRFVFDATAITTLRTKATSEKVPNPSRVEALMEFVVQHLSTAFKTAKSETPETLMITHPVNLRKRIEPPLPDSTFGNVIWLAFAFYDCDPSETKIKPGDVVERVREAFAALDKESISELETDDAFTSLSELLESVYTNEKIKIYRFTSTCNMGFYDVDFGWGKPVWVAHMGNMVDYRCKQQIVFMETGHMSKDIELWLAAEEDELSVLEKNAEFLAYATPNPTIWLDSDGTN
The following text describes a protein:
Function:
Catalyzes the synthesis of activated sulfate.
Sequence:
MSQSNSDDSASSSTQQAGDGQDDVQQNIVWHAHTVSREDRESKLGQRGVVVWFTGLSGCGKSTIANELDRLLIDRGATCTLLDGDNVRHGLCAPPSVLKEEHGEDFAGRFGLGFGPTDREENIRRIGAVTELFASAGVIVLAAFVSPYQRDRDRVRNTIESSGRAGDFLEVFVDTPLEICKQRDPKGLYQKAIAGEIKNFTGISDPYDAPPSPEIHLKWREGQTPHDQASEIIREMEKRGVLGPAKG
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MEPELGEPCKGKLWGLNGGHSGSPGLASLGRKNSLRAGSEVGKQRAWGRRQGKGSLQGWRVRTREMGSKPEPKGVPRGMGLMLGRGCRGPAVVAVLEAQAAGWAWNLEPMISLGVRDLGFQTICFIQRLSADQEPGGSNPILSGSGTSGLKCTLLLGRTWSLRGRMAQDLSEKELLKMEVEQLKKEVKTPRALISKTGKEIKDYVEAEAGNDPLLKGIPEDKNPFKEKGGCLIS