lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTTDALTALLPFIVLSAAAVAVMLAIAIRRSFRLVFWLTVGGLLAGLSTLPHASSVAPLQVTDLLRVDAYGLFFHALFLLAALVVALLCLAYFRRRENENEEIFVLLLTSTLGALLLVSSAHLAMFFLGLEVLTISLFPMIAYSVRASRPLEAGIKYLMLSGLASSFLMFGMAMVYGDLGVLSFEQIGAHGAELEQKPLALAGLFLILAAIGFKLSLVPFHLWTPDVYQGAPTPVTAFLATVSKASVFALLLRFFTAAHAERSETFLCVLGLLAVVSILAGNLLALLQVSLKRLLAYSSIAHMGYLLTGFVAAGLLRRDLQTETIAFYLAAYTVTSLTAFGAISALSDDDRESDRLSDYAGLFWRSPWLAAVLTLSLLSLAGIPLTVGFVGKFYVFAVGVQAETWPLVATVVIGSGIGIYYYLRVVLTMIQPAGVGQRVTLHPAAGTALAAAALVILAAGLFPQPLIDAAANVPQPPPTADSPQRLTATGGLP
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MEVADRMMSNGVDNDRRSSPSPHRGNGDMNNGNGNGNRDSRERSPPRGNSRERSPPRGGSPNRGGSPNRGGSPNRGGSPNRGGSPSRDDKRRYGNGGNGETRNRLANTASPSNVLGVFGLAPQTEERDLKDEFSRFGKIDHVDLIMDRKTGRSKCFGFVYFENKEDAVRAKEECQDLQLHGKSIRTDFSATKKPHEPTPGKYFGNPRYDSRRSPPRFSPYGGGDRYGRGDYGGRGGGGDRYGRDDRGGDRYGRDDRGGDRYGGRDDRGGDRYGGRDERGGDRGGDRYGRDDRDRHREDSRDRYNDRGGDRYNDRFRDERPRDSYRR
The following text describes a protein:
Function:
Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MNKFLALLFVLALFANIAFSCEGHPEHDHGDGDHEHDHDESFVKILDSDNFHNSVSEHDVTLVMFYAPWCGHCKTLKPLYEEAAKQLSANKKIAIAKVDCTQHEQLCKQNKVQGYPTLVVFKNGKAEPYEGDRTTKSIVQTLEEELKPTISTLESNEDIEEFKKQHPISVVGFFDNDHDDRFKLFSELAGNNKKSAKFAVVIDKDFSKEHVESTPNVVLFRSFDEPTVAHKGEFDSESLIKFIKGNSVPLLGEINRNTYKKYESIAVPLAYLFIDSTQDNTQVLEDVKKIATSQKGNAVFCWVDMKKFPQQATHMGLSGKVVPAISVDSVANKARYNFDEKETFSFDTVSKWIQDVIGGKVSPFVKSQPEPESNDAPVKVAVGTTFKKLVLDSPKDVLVEFYAPWCGHCKNLAPIYDKLGEYLKDVESVSIVKIDADSNDVPSDIEIRGYPTIMLFKADDKENPISYEGQRNDHMNFVEFIQDNAAIEFKLPSSQTDDNVESKKDSSAKHDEL
The following text describes a protein:
Function:
Regulates an ATP-dependent metal transporter (e.g. manganese transporter). Probably involved in the metabolism of auxin conjugates such as indole-3-acetic acid-leucine (IAA-Leu) and IAA-Phe. Required for root development.
Subcellular Localization:
Cytoplasm.
Sequence:
MASESSTHKTKLEKKTCLSFLSSFTRSQIVYPTQGISHYYPSCHMMVHAMNITLCDNFDFKRANPNYHPYILRLYCGVLFWIQCLRAGNDVNDLTDVQHRFLNRFLDNHPLETLAVPGPLLGLFKTLCSSQPEFPHNHNGKVYPRIPAQPGPARRDAFMRDLLESHFLPNVPGIFALLEDLTAFLPNTSRLSKERQAHSRYPKYPDQSLNEAFADCYSNFNFQVTSAADNLEKISSFLHMKHSMAWFNQVKGVADDVAASFEGSGTLADCSPHGLVANQVMVVLSTPEHLPESPNCIADKRATYEFGYQLKSTVRNLPPLAEALAAFSQTYIRMFPNHPFFGTFGSKTLDHGPFWKIRPIGSSLTDNSSYLTIPSIVKQAFKGPAT
The following text describes a protein:
Function:
Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context. Upon insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm.
Sequence:
MANGTNASAPYYSYEYYLDYLDLIPVDEKKLKAHKHSIVIAFWVSLAAFVVLLFLILLYMSWSASPQMRNSPKHHQTCPWSHGLNLHLCIQKCLPCHREPLATSQAQASSVEPGSRTGPDQPLRQESSSTLPLGGFQTHPTLLWELTLNGGPLVRSKPSEPPPGDRTSQLQS
The following text describes a protein:
Function:
As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. Binds to single-stranded sequences participating in DNA replication in addition to those mediating transcriptional repression (URS1) and activation (CAR1). Stimulates the activity of a cognate strand exchange protein (SEP1). It cooperates with T-AG and DNA topoisomerase I to unwind template DNA containing the simian virus 40 origin of DNA replication.
Miscellaneous:
MISCELLANEOUS: Present with 4100 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSSVQLSRGDFHSIFTNKQRYDNPTGGVYQVYNTRKSDGANSNRKNLIMISDGIYHMKALLRNQAASKFQSMELQRGDIIRVIIAEPAIVRERKKYVLLVDDFELVQSRADMVNQTSTFLDNYFSEHPNETLKDEDITDSGNVANQTNASNAGVPDMLHSNSNLNANERKFANENPNSQKTRPIFAIEQLSPYQNVWTIKARVSYKGEIKTWHNQRGDGKLFNVNFLDTSGEIRATAFNDFATKFNEILQEGKVYYVSKAKLQPAKPQFTNLTHPYELNLDRDTVIEECFDESNVPKTHFNFIKLDAIQNQEVNSNVDVLGIIQTINPHFELTSRAGKKFDRRDITIVDDSGFSISVGLWNQQALDFNLPEGSVAAIKGVRVTDFGGKSLSMGFSSTLIPNPEIPEAYALKGWYDSKGRNANFITLKQEPGMGGQSAASLTKFIAQRITIARAQAENLGRSEKGDFFSVKAAISFLKVDNFAYPACSNENCNKKVLEQPDGTWRCEKCDTNNARPNWRYILTISIIDETNQLWLTLFDDQAKQLLGVDANTLMSLKEEDPNEFTKITQSIQMNEYDFRIRAREDTYNDQSRIRYTVANLHSLNYRAEADYLADELSKALLA
The following text describes a protein:
Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MLLQKTLCIVKPDGVRRGLIGDVVSRFERVGLKMVAAKMLIVDESLAKKHYLYDDIVFRHSEAVWNSLIKFISNSPVFTFVVEGVESIEVVRKLCGATEPKLAIPGTIRGDFSYHSFKYSNEKGFSIYNVIHASANEADAMREIPIWFKDNEILNYKRDDECEHYYC
The following text describes a protein:
Function:
Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
Sequence:
MEDIEDVLGPAGFSGGGAPPGLRLPLSTVAVKPKRRPSRLVQTQPQPDARIPGTQTIYVKTFGCSHNQSDSEYMSGQLSAFGYAITEEPEGADLWLINTCTVKNPSQSAMSTLISKCKTANKPLVVAGCVPQGSRDLKELEGISIIGVQQIDRVVEVVEETLKGHEVRLLSRKTLPSLDLPKVRKNRFIEILPINVGCLGACTYCKTKHARGHLGSYSIDSLVDRVKIVVSEGVREIWLSSEDTGAYGRDIGTNLPNLLNAIVAELPADRSTMLRIGMTNPPFILEHLNEIASILRHPCVYTFLHVPVQSGSDAVLQAMNREYTVSEFRMVVDTLCELVPGMQIATDIICGFPGETDEDFVETVNLIKEYQLPQVHISQFYPRPGTPAARMKKVPSIEVKKRSRELTSVFEAFSPYEGLKGKVERIWITEIATDGVHLVGHTKGYIQVLVIAPDSMLGTSADAKITSVGRWSVFGEVIEGTIAVKEAALQQNSAEVQVENRPNRVEEAVCSTNTCDSDSCACSGVESVAQQCTPQRCEGPSDAPANYGDATRQETPQSTLVRRNVDGAGKTSESDAEKSRGDDHQVNVVTRRALNIDRILWGGLAVSFATTVAILVMLTYKIFYTSS
The following text describes a protein:
Function:
Involved in protein precursor import into chloroplasts. May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope.
Miscellaneous:
MISCELLANEOUS: There is a partial copy of the N-terminus (positions 1-343) of ycf1 in the inverted repeat (ycf1-A, BAA84433).
Subcellular Localization:
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Sequence:
MMVFQSFILGNLVSLCMKIINSVVVVGLYYGFLTTFSIGPSYLFLLRARVMDEGEEGTEKKVSATTGFIAGQLMMFISIYYAPLHLALGRPHTITVLALPYLLFHFFWNNHKHFFDYGSTTRNEMRNLRIQCVFLNNLIFQLFNHFILPSSMLARLVNIYMFRCNNKMLFVTSSFVGWLIGHILFMKWVGLVLVWIQQNNSIRSNVVIRSNKYKFLVSELRNSMARIFSILLFITCVYYLGRIPSPIFTKKLKGTSETGGTKQDQEVSTEEAPFPSLFSEEGEDLDKIDEMEEIRVNGKDKINKDDEFHVRTYYNYKTVSENLYGNKENSNLEFFKIKKKEDHFLWFEKPFVTLVFDYKRWNRPNRYIKNDKIENIVRNEMSQYFFYTCQSDGKERISFTYPPNLSTFFEMIQKRIPSFTKEKKTFDQVSTYWSLIHEEKRENLKKEFLNRIEALDKEWSVENILEKTTRFCYNEAKKEYLPKIYDPFLHGISRGRIKKLPPFQIITETYRKNNLGGSWINKIHGLLLKINYKKFEQTIEKFNRKSLSIEKKLSFFSEPQQEEKINSEEEIKTFKFLFDIVRTDSNDQTLIKNFMDFPEINKKVPRWSYKLISELEELEGENEENVPMEPGIRSRKAKRVVVFTDKEPHGEIYTNLKDNQNSDQNDEMALIRYSQQSDFRREIIKGSMRSQRRKTVIWEFFQAKVHSPLFFDRIDKLFFFSFDIWGLKKKIIKNFIWKKKIDKKEEEQSKREETRRIEIAETWDSFLFAQIIRGSLLVTQSILRKYIILPLLIIIKNSVRMLLFQFPEWSQDLKDWKREMHVKCTYNGVQLSETEFPRNWLTDGIQIKILFPFYLKPWHKSKFQASQKARLKKTKDKGEKNDFCFLTVWGMETELPFGSAQRKPSFFEPISKELKKRIKKLKKKSFVVLKIFKERAPIFLKVAKETKNWILKNFIFIKGISKRNLIPLFGPREIYELNEPKKDSIISNQMIHELSVQNKSLEWTNSSLSEKKIKNLIDRKKTIRNQIEEISKEKQNLTNSCTKLRYDSKIIESSKKIWQTFKRKNTRLIRKSIFFFKFCIEQMSIAIFLGIINIPRITTQLFFESTKKILDKYIYKNEENGEKKKNTLYFISTIKNLISNKKKMSYDLCSLSQAYVFYKLSQIKVSNFCKLKAVLEYNICITSFFVKNKIKVFFQEHGIFHYELKNKTFLNSEVNQWKNWLRSQYQYNLPQISWARLVTQNWKNKINKDSLVLNPSLTKEDSYEKKKFDNYKKQKFFEADSLLNPKHNVKKDSIYNLFCYKSIHSTEKNFDMSIGIALDNCLVSSFLEKYNIRGMGEIRHRKYLDWRILNFWFTKKVTIEPWVDTKSKKKYINTKVQNYQKIDKITQTDLANKKRNFFDWMGMNEEILNQRITNFEFFFFPEFFLFSSTYKMKPWVIPIKLLLLNFNENINVNKKIIRKKKGFIPSNEKESLRFYNLNKEEKESAGQVELESDKETKRNPEAARLNQEKNIEENFAESTIKKRKNKKQYKSNTEAELDLFLTRYSRFQLRWNCFFNQKILNNVKVYCLLVRLNNPNEIAVSSIERGEMSLDILMIEKNFTFAKLMKKGILIIEPVRLSVQNDGQLIIYRTIGISLVHKNKHKISKRYKKKSYINKKFFEKSITKYQNKTVNKKKNNYDFFVPEKILSPKRRREFRILICFNLKKKNARDTNSRFDKNIQNLTTVLHKKKDLDLDKDKNNLINLKSFLWPNFKLEDLACMNRYWFNTTNGNHFSMIRIRMYTRFPIP
The following text describes a protein:
Function:
Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.
Sequence:
MKSSLLPLEHAALTQRDFELIRQFLYEEAGIFLSDIKKSLVASRLCRRLKETGYENYGDYFEFVKNHSEHSEYHHFIDALTTNETFFFREIEHFEFVKNLIKTHPQKKSWQAWSAACSSGEEAYSLAMLLADHLGIDGQWQVQGSDISQRVLAKAEMAHYPLERNDGIGFERLQKYCLKGIGKQSGTFLIDETLKAKVTFFAMNLTQSCESVGMCDLIFIRNVMIYFDTVSKQRVINHVLKQLKVGGYLFISHTESLMHVKHGLKQIKPSIYQRI
The following text describes a protein:
Function:
Catalyzes the dehydration of L-2-keto-3-deoxyarabonate (L-KDA) to alpha-ketoglutaric semialdehyde (alphaKGSA). Is involved in a degradation pathway of L-arabinose that allows A.brasilense to grow on L-arabinose as a sole carbon source.
Sequence:
MTSSSTPRHRGIFPVVPTTFADTGELDLASQKRAVDFMIDAGSDGLCILANFSEQFAITDDERDVLTRTILEHVAGRVPVIVTTSHYSTQVCAARSLRAQQLGAAMVMAMPPYHGATFRVPEAQIFEFYARVSDAIAIPIMVQDAPASGTALSAPFLARMAREIEQVAYFKIETPGAANKLRELIRLGGDAIEGPWDGEEAITLLADLHAGATGAMTGGGFPDGIRPILEAWREGRHDDAYARYQAWLPLINHENRQSGILTAKALMREGGVIASERPRHPMPELHPDTRAELLAIARRLDPLVLRWAH
The following text describes a protein:
Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MTVYSYLVILFILLDNYCSAYGYGYSYYHRRHFDPAIASFTKEPYIGAVWFTQHGDYMYVNGSVAGLPPGKLLGTHVHRYGGLGNMCLEAGPHFNPFNQRHGPRHGYPRHAGDLGNIRVGRGGVAKFDFYVTIKGLGPFDGFIGRALVIHANRDDLGRNRDEGSRTTGNSGPRLACATIGFRAP
The following text describes a protein:
Function:
Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.
Sequence:
MMPRATVKLIITGDDFGYCPRRNQGIVECFLTGAVSNVSLLVNGAAVVDAVQLARRHHIPIGLHANLSEGSPVCPALKESSSLLNAEGFFHGKMGIRRALAEGRLNMAEVKQELTAQVELFRELTGHLPYHMDGHQHVHVLPEIRHVFAQLLVDYGIMYTRVPIEPDLPRCSWIDPPLMAFYRSVEKDSLETVDVFQKYHIRWPDIYIGLSTMGKNMSVSNIIGAIDNATAAYQAKKDSVAPLSPLLGSGREARSVTVELMTHPGYPSLPPVGGCGEGPDDFSQSWERLHELETLKKPELQSCYKARNIELCSFKELKV
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MLCCLFGVQIKCALLKLLQHNVLDVTPVAAIRGGAPTVAYNINVQEALYRLRFPKFIELAKGMFGVEGEVIMEEVLVQGRVRMDQSLETMAYNLAEQRRQDQKQKAQEAEGDQAAAAEDDDISEEELDECRHLVQEAFVEMAKKRYISRVHPLDLKVVEPEEGPEFPASIMGRGQDKGATSNLNSKSAAAAAAGGGGNASSANGANKNGKAAGEDGITVRGKKRKAPSAPSGNAIPVELQMILEADEAARKGNDDSEAEWEPNSASSSTSSGRGSKRKKNSKRAKLPTRGTSSGDGTTCGETSGEDAPDGSGATTDERSLVWRFGVTQLLRDLRHKACIKFATENINAVAGVIVEAMLQHSSPREREKDEPTSFPVSARDLFEMESVKKALPSEANNPWRLLLNYIMVMCRDKSGMVMKVSQEAFDPTQARSGDGGQYVVHMQKIVEFLQQATTRAYIQDKYGVASARIVRLLMEKRQLEQKTIGELALLPSNDARHRLYELYTDKLLKMQEIPKRADHNPAFTFFCWSVDVPQMQTRIAERVQDSLCRLRRRRKFEAEENKELIARSEQLVEANDLDKFDKLSRSLDRLDRAIIHLDGMLMLYRDF
The following text describes a protein:
Function:
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(KLHDC2) complex specifically recognizes proteins with a diglycine (Gly-Gly) at the C-terminus, leading to their ubiquitination and degradation. The CRL2(KLHDC2) complex mediates ubiquitination and degradation of truncated SELENOK and SELENOS selenoproteins produced by failed UGA/Sec decoding, which end with a diglycine. The CRL2(KLHDC2) complex also recognizes proteolytically cleaved proteins ending with Gly-Gly, such as the N-terminal fragment of USP1, leading to their degradation. May also act as an indirect repressor of CREB3-mediated transcription by interfering with CREB3-DNA-binding.
Subcellular Localization:
Nucleus.
Sequence:
MADGNEDLRADDLPGPAFESYESMELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEWIQFNHPYTEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEILIFSVQPKSLVRLSLEAVICFKEMLANSWNCLPKHLLHSVNQRFGSNNTSGS
The following text describes a protein:
Function:
Forms a receptor complex together with receptor ilcr-1, which upon activation acts as a modulator of neuronal activity. Binding of the ligand ilc-17.1 to the ilcr-1/2 receptor complex triggers a signaling cascade that activates the downstream signaling components actl-1, pik-1 and nfki-1, and results in increased neuronal activity in RMG interneurons in response to input from oxygen-sensing neurons. This leads to increased animal movement and promotes aggregation behavior.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MVRLCTTNFLAYRATGSPLLLLYFYLCSLSSVKSSAAASYTNASDYVLRNVFEHSDQCYKDSFVYVRADDKKSDPFITYSTTKECSERLKKNDLPEKLPTCPPGLIDLELKPVYVPKSQISYPYANLNISVTAHSSVDTIAFRLECLSASDGSDVYCSNSKAMYINGVKEWPCRGIHLSSRVQYPTRFSYSCFRLTSFSVYAINATILPQKCRVSTIMTAPYFDDMFPEILVDPTTNQSIITKTDPFWAPMLSADFSDKNAIWVRLGKAERAECETMVVNVYKEHDDDSQKVTFLEILTVKCPETAVKWENQKAGRYLLTAYVPIRGCKFYCEKKERGCRQCLRTHLNLVIYKNRASLSWLALQKFKDYGFEIFIAVVVLLILIIVLAVTGFGYVLWRDKVRSREVRNIALTEFVKVMIVYADDNDLHTDCVKKLVENLRNCASCDPVFDLEKLITAEQIVPSRWLVDQISSLKKFIIVVSDCAEKILDTEASETHQLVQARPFADLFGPAMEMIIRDATHNFPEARKKYAVVRFNYSPHVPPNLAILNLPTFILPEQFAQLTAFLHNVEHTERANVTQNISEAQIHEWNLCASRMMSFFVRNPNWLETRWKPKDELAALHLKRQSPVIVPIQTEEDRIAASIKYNLVPPQALVDSDDEDDVDLQPHASHQNQPLILLPPEQCGPDSDSDSESDSSSESESESDNEGEDPKTIVVKKS
The following text describes a protein:
Function:
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MRNLKLFRTLEFRDIQGPGNPQCFSLRTEQGTVLIGSEHGLIEVDPVSREVKNEVSLVAEGFLPEDGSGHIVGVQDLLDQESVCVATASGDVILCSLSTQQLECVGSVASGISVMSWSPDQELVLLATGQQTLIMMTKDFEPILEQQIHQDDFGESKFITVGWGRKETQFHGSEGRQAAFQMQMHESALPWDDHRPQVTWRGDGQFFAVSVVCPETGARKVRVWNREFALQSTSEPVAGLGPALAWKPSGSLIASTQDKPNQQDIVFFEKNGLLHGHFTLPFLKDEVKVNDLLWNADSSVLAVWLEDLQREESSIPKTCVQLWTVGNYHWYLKQSLSFSTCGKSKIVSLMWDPVTPYRLHVLCQGWHYLAYDWHWTTDRSVGDNSSDLSNVAVIDGNRVLVTVFRQTVVPPPMCTYQLLFPQPVNQVTFFAHPQKSNDLAVLDASNQISVYKCGDCPSADPTVKLGAVGGSGFKVCLRTPHLEKRYKIQFENNENQDVNPLKLGLLTWIEEDVFLAVSHSEFSPRSVIHRLTAASSEMDEEHGQLNVSSSAVVDGVIISLCCNSKTKSVVLQLADGQIFKYLWESPSLAIKPWKNSGGFPVRFPYPCTQTELAMIGEEECVLGLTDRCRFFINDIEVASNITSFAVYDEFLLLTTHSHTCQCFCLRDASFKTLQAGLSSNHVSHGEVLRKVERGSRIVTVVPQDTKLVLQMPRGNLEVVHHRALVLAQIRKWLDKLMFKEAFECMRKLRINLNLIYDHNPKVFLENVETFIKQIDSVNHINLFFTELKEEDVTKTMYPAPVTSSVCLSRDPDGNKLDLVCDAMRAVMESINPHKYCLSILTSHVKKTTPELEIVLQKVHELQGNAPSDPDAVSAEEALKYLLLLVDVNELYDHSLGTYDFDLVLMVAEKSQKDPKEYLPFLNTLKKMETNYQRFTIDKYLKRYEKAIGHLSKCGPEYFPECLNLIKDKNLYNEALKLYSPSSQQYQDISIAYGEHLMQEHMYEPAGLMFARCGAHEKALSAFLTCGNWKQALCVAAQLNFTKDQLVGLGRTLAGKLVEQRKHIDAAMVLEEYAQDYEEAVLLLLEGAAWEEALRLVYKYNRLDIIETNIKPSILEAQKNYMAFLDSQTATFSRHKKRLLVVRELKEQAQQAGLDDAVPHGQESDLFSETSSVVSGSEMSGKYSHSNSRISARSSKNRRKAERKKHSLKEGSPLEDLALLEALSEVVQNTENLKDEVYHILKVLFLFEFDEQGRELQKAFEDTLQLMERSLPEIWTLTYQQNSATPVLGPNSTANSIMASYQQQKTSVPVLDAELFIPPKINRRTQWKLSLLD
The following text describes a protein:
Function:
Binds together with bS18 to 16S ribosomal RNA.
Sequence:
MRKYEIMCLISPELSEEDFKTLYEGIQQDIQNLGGEVQNVDVWGKRTLAYPVKKFTEGYYVVMNFLFPQTQLPEFERRLKLREKLLRYMITLLEKEE
The following text describes a protein:
Function:
Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor; In the context of N-glycan degradation, cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MARGERKRRSGPPADAPGLRASDKGVQGAMGRRREGRAGMGPGAGSRRGPGGRGAGGRGPGVAALAALGLALGLGLGLGLSWRGILAWQRARRAVTLHPAPPALPPNSSSALAAPDLFWGTYRPHVYFGMKTRSPRAPVTGLMWLQQGAPPGMLGQLRHTCEQGDGMGPYGWELHDGVNFGRQRLHDGSLLLTTEFVKRPGGSHGGDWSWRVTAEPQTPEGSVPPLLSLFFYVATDGQGTLWPDPGTGGQLDGINGHTEELGDFRLILLPPTSAKGTALKHGSYNILWMPSPGLPLLTEAVKNRLNRWFQHRPPGGSPERYLGLPGSPQWEGESPQPGHTVQGQVVVQQLTLKPPFRVELVFESGSVGWGETRPGGRLAGPVLSQALDAHATAFTNRFEETFRLEARGLSSGEQALGRAALSGLLGGIGYFYGQGLVLPDPGDEPEEDPAPTPSLFPPAPLFTAVPSRSFFPRGFLWDEGFHQLLVHQWEPQLTREALGHWLGLLNVDGWIGREQVLGDEARARVPPPFLVQRAAHANPPSLLLPVIRMLDSGDPADLDFLRASFPRLQAWFSWLQQSQAGPVPLSYRWRGRDQAAAGLLNPKTLPSGLDDYPRASHPSTDERHLDLRCWVAFGASVLARLAQKIGETQAEAELADLATKLKDENGLDSLHWAPDLGAFADFGNHTGAVRLARGPQGLVRVVGRPPPRLQHVDALGYVSLFPLLLRLLSPDSPHLGPLLDLLSDSRHLWSPFGLRSLSASSPLYGQRNSEHDPPYWRGAVWFNINYLALGALDHYGRLEGPHQAQASQLHTQLRTNLVGNVWRQYRDTGFLWEQYSDRDGHGMGCRPFHGWTSLVLLAMAEDY
The following text describes a protein:
Function:
May catalyze the synthesis of indole-3-acetic acid (IAA)-amino acid conjugates, providing a mechanism for the plant to cope with the presence of excess auxin.
Sequence:
MAAKGISTIGAASRSLSSSLMAAAKEPDVENLRLIEELTSNVDAVQERVLAEILGRNADAEYLDKCGLDASDTDRATFRAKVPVASYDDLKPYVKRIANGDRSPILSTHPIIEFFTSSGTSAGERKLMPIVTDEMARREVLSSLATSVLNVYVPGLHTGKGLYFLFARSETKTPGGLTAQPALTSVYKSEHFKRAYAYTSPMAAILCEDASQSMYAQMLCGLCQRHDVLRVGAVFAAALVRAIRFLQLNWAQLAADIETGELNPRVTDPSDRECSRGDWTGIVTRLWPKTKCLNVVVTGVMAQYIPTLQYYSGGLPIVSGMYASSECFFGLNLRPLCGPSEVSYTIMPNTAYFEFLPVGEAVDASNLVELARVEDGREYEVVVTTYAGLNRYRVGDVLCVTGFHNAAPQFRFVRRQSVLLSIEADKTDEAELQRAVERASSALLRPRGASIVEYTSRACTERVPGHFSPALPHWTLAP
The following text describes a protein:
Function:
Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein.
Sequence:
MALVRGAEPAAGPSRWLPTHVQVTVLRARGLRGKSSGAGSTSDAYTVIQVGREKYSTSVVEKTPGCPEWREECSFELPPGALDGLLRAQEADAGPAPWATGSAAACQLVLTTMHRSLIGVDKFLGQATVALDEVFGAGRAQHTQWYKLHSKAGRKEKERGEIQVTIQFTRNNLSASMFDLSAKDKPRSPFSKIKDKMRGKKKYDLESASAILPSSALEDPELGSLGKMGKAKGFFLRNKLRKSSLTQSNTSLGSDSTLSSASGSLAYQGPGAELLTRSPSRSSWLSSEGGRDSAQSPKLLTHKRTYSDEASQIRAAPPRALLDLQGHLDGASRSSLCVNGSHIYNEEPQGPPRHRSSISGPFPPSSSLHSVSSRPSEEGPRSADDSWGRGSRRTSISEAVPGQEELSSQAKVLAVGASRSGEEEGARPSEGRPVQVATPMVASSEAVAEKEGARKEDRKPRMGLFHHHHQGLSRSEMGRRGSLGEKGGPSLGASPHHSSSGEEKTKSSWFGLREAKEPTQKPSPHPVKPLSAAPAEGSPDRKQSRSSLSSALSSGLEKLKTVTSGGIQPVAPAPQVGQTADTKRLKDSGVLDQSAKYYHLTHDELIGLLLQRERELSQRDEHVQELESYIDRLLVRIMETSPTLLQIPPGTPK
The following text describes a protein:
Function:
Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSTTGSMRSLVLHSYKTLRRTIDQVFQGDTDTIRAAKIQVRQEFAKNAFEPDSAKIQELLKVAEEVDLVLRRDVVQAVRNEEGRYELQLKPHHLHDNASVAHPTEKPK
The following text describes a protein:
Function:
Synaptotagmin family member which does not bind Ca(2+). Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses. Plays a role in dendrite formation by melanocytes (By similarity).
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane; Single-pass membrane protein.
Domain:
Unlike in other synaptotagmin family members, the first C2 domain/C2A does not bind Ca(2+) neither mediates Ca(2+)-dependent phospholipid binding. An aspartate-to-serine substitution in this domain inactivates Ca(2+)/phospho-lipid binding.
Sequence:
MAPITTSRVEFDEIPTVVGIFSAFGLVFTVSLFAWICCQRRSAKSNKTPPYKFVHVLKGVDIYPENLSSKKKFGGDDKSEAKRKAALPNLSLHLDLEKRDLNGNFPKTNPKAGSSSDLENVTPKLFPETEKEAVSPESLKSSTSLTSEEKQEKLGTLFLSLEYNFEKKAFVVNIKEAQGLPAMDEQSMTSDPYIKMTILPEKKHKVKTRVLRKTLDPVFDETFTFYGVPYPHIQELSLHFTVLSFDRFSRDDVIGEVLVPLSGIELSDGKMLMTREIIKRNAKKSSGRGELLVSLCYQSTTNTLTVVVLKARHLPKSDVSGLSDPYVKVNLYHAKKRISKKKTHVKKCTPNAVFNELFVFDIPCESLEEISVEFLVLDSERGSRNEVIGRLVLGATAEGSGGGHWKEICDFPRRQIAKWHMLCDG
The following text describes a protein:
Function:
Probable inhibitory regulator of the Ras-cyclic AMP pathway. Plays a role in dendrite formation by melanocytes.
Sequence:
MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVHLPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEICLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHWDEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAEEDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGDCRQDLATKLVKLFLGRGLAGRFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVRDFLDRLVDVDGDEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGETLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVNELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSDPLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEVLADLDRAHEEFQQQERGKAALGPLGP
The following text describes a protein:
Function:
Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.
Subcellular Localization:
Cytoplasm.
Sequence:
MKTVVVIGGGITGLSTMFYLEKLKKDYNIDLNLILIEKEEYLGGKIHSVEEKDFIMESGADSIVARNEHVMPLVKDLNLEDEMVYNETGISYIYSENMLHPIPSDTIFGIPMSVQSLFSSTLVSTKGKIVALKDFITKNKEFTKDTSLALFLESFLGKELVERQIAPVLSGVYSGKLNELTMASTLPYLLDYKNKYGSIIKGFEENKKQFQSAGNKKFVSFKGGLSTIINRLEEVLTETVVKKGVITTAVSKQEDRYEISFANHETIQADYVVLAAPHDIAQTLLQSNELNEQFNTFKNSSLISIYLGFDILDEQLPADGTGFIVTENSDLHCDACTWTSRKWKHTSGKQKLLVRMFYKSTNPVYETIKNYSEEELVRVALYDIEKSLGIKGEPEVVEVTNWKDLMPKYHLEHNQAVQALQEKMTNLYPNVYLAGASYYGVGIGACIGNGKNIANEIMDTLNK
The following text describes a protein:
Function:
Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.
Sequence:
MADVSATDVVALAEDIDGADLVKKSGRGGKGGRGGKGGGGQSREVVISKALSKLLRHAAEDEGLKLDEEGYARLDLVMQWPRLKSLKPTFADIRTAVHDNAKQRFSMKANPALPTPPSPSSENPSDWVIRANQGHSIAIDSATLLVPITIEKGNVPETCVHGTYFAFYEEIVKSGGLKKMGRNHVHFGTGVPEEGGVISGMRGDAEVLIYVDVKKCLEEEPDVKWWVSDNGVVLSEGNADGVVGTRFWKRVEGRKEGGVLWEDGVKVKELDESLKNRKAPMGKGGRGGGERGGGRGGRGQGRGGKAMGGTADTNIEEAQPVAET