lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation.
Subcellular Localization:
Late endosome membrane; Single-pass type I membrane protein.
Domain:
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Sequence:
MRSVQIFLSQCRLLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSPVSYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATISTCMGGLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEIEWQMAPYENKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWSFGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRGRLNCIMGSGRTGFSNCSYISFFKHISSGATCLNNIPGLGYVLKRCGNKIVEDNEECDCGSTEECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWAPPFCEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFRQVIGNHLKPKQEKMPLSKAKTEQEESKTKTVQEESKTKTGQEESEAKTGQEESKAKTGQEESKANIESKRPKAKSVKKQKK
The following text describes a protein:
Function:
Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.
Sequence:
MSEVIRVLLEEATKVAEKIGAKALVIMEELPEEEIPDVGITVVIVGSTFDVEKDNVKRISIPQNLDLNNLLNLISAFLLEHGILSEGDSFVYVTENLIGVRTIKRSIVAMKSFFAQNQNVLQRMLEIAIELSIEGREGNPVGTIFVIGDTRRVLKHSRQLIPNPFKGHRINVLDKESKEIIKEFAQLDGAFLIREDGRIVAAGRYLEVEPRVIDLMLPPGLGSRHIAAAGITKITSAMAISLSESGTIRIFKNGLMLLEYNPRLKY
The following text describes a protein:
Function:
Catalyzes the SAM-dependent methylation of geranyl diphosphate (GPP) to yield (E)-2-methylgeranyl diphosphate (2-MeGPP).
Sequence:
MTKSIHENGTAASVYQGSIAEYWNQEANPVNLELGEVDGYFHHHYGIGEPDWSVVEGDAATSHERTTRELHRLETWQAEFLLDHLGGVEPEHRIMDAGCGRGGSSFMAHERFGCSVEGVSLSRKQVDFANAQARERGVADKVAFHQLNMLDTGFDTASMRAIWNNESTMYVDLHDLFAEHSRLLARGGRYVTITGCYNDVYGLPSRAVSTINAHYICDIHPRSGYFRAMAANRLVPCAVVDLTEATVPYWRLRAKSPLATGIEETFIEAYTSGSFQYLLIAADRV
The following text describes a protein:
Function:
Chitinase involved in the remodeling of chitin in the fungal cell wall. Plays a role in cell separation.
Subcellular Localization:
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor.
Sequence:
MLSFKSLLAAAVVASSALASASNQVALYWGQNGAGGQERLAQYCQEADVDIILLSFLNLFPDPLNVNFANQCGNTFESGLLHCSQIGADIKTCQSLGKTVLLSLGGGVGDYGFSDVASATKFADTLWNKFGAGEDPERPFDDAVVDGFDFDIEHGGATGYPELATALRGKFAKDTSKNYFLSAAPQCPYPDASLGDLLSKVPLDFAFIQFYNNYCSINGQFNYDTWSKFADSAPNKNIKLFVGVPATSNIAGYVDTSKLSSAIEEIKCDSHFAGVSLWDASGAWLNTDEKGENFVVQVKNVLNQNACVAPSSSATTQSTTTTSSAVTQSTTTTSAAITQSATTTSAAVATKSNQIVTSSSSSSSSIFYGNSTTESSTGIATGTVLPTGSNENAATTGSGSNTKLAISTVTDVQKTVITITSCSEHKCVATPVTTGVVVVTDIDTVYTTYCPLTNSQVYVSVKTVVCTEETCVPSPTSTSQKPKASTTIKGVEKGQTTSYPVVGTTEGVKKIVTTSAQTVGSSTKYVTIELTSTITPVTYPTSVASNGTNTTVPVFTFEGGAAVANSLNSVWFTVPFLLAAFAF
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MASVYTPFVYWAQRKDKLSLKVDLRDVSDPNVQLDEYGLTFRAYGFGAKGQHEYGFQMDFFKQVDPEKSMYRTTPQGVEFMLMKQDKQWWSRLVEQEKRPGFLKVDFDKWRDEGDSESEAEEEKAKRLEAYRQESLKKFEEEMKEEMESRAAIKYLKTWWLFAYNFFQFMGYSFIFVSCVIRYMMYHRDSFKDTWEFTGQMMMTCQLMAFLEYVHAEVGLVNSKPIFPLIQTLGRNFILFMVIYPEELMYPLPVVTYLFTTWSCIEVARYIFRFRYPFYMFNLIGKENLPAKIYKVMQWLRYSIWIPLYPLGFLLEAYCIFTAVPYYERSEKFSYQYGKYRLHYPLLMKLYLMMLAAGGTLLLKYMVRQRRRKAAVKRGKERERAAQERAAAHQHID
The following text describes a protein:
Function:
Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity. Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria. ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering pro-inflammatory NF-kappa-B signaling. May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A. May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A. May play a role in ciliogenesis.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Note=Localized at the base of primary cilia.
Sequence:
MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT
The following text describes a protein:
Function:
Involved in the fatty acid remodeling steps of GPI-anchor maturation where the unsaturated acyl chain at sn-2 of inositol phosphate is replaced by a saturated stearoyl chain. May catalyze the second step of the fatty acid remodeling, by reacylating a lyso-GPI intermediate at sn-2 of inositol phosphate by a saturated chain. The fatty acid remodeling steps is critical for the integration of GPI-APs into lipid rafts.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MYQVPLPLDRDGTLVRLRFTVVALVTVCCPLVAFLFCILWSLLFHFKETTATHCGVPNYLPSVSSAIGGEVPQRYVWRFCIGLHSAPRFLVAFAYWNHYLSCASPCSCYRPLCRLNFGLNVVENLALLVLTYVSSSEDFTIHENAFIVFIASSLGHMLLTCILWRLTKKHTVSQEDRKSYSWKQRLFVINFVSFFSALAVYFRHNMYCEAGVYTIFAILEYTVVLTNMAFHMTAWWDFGNKELLITSQPEEKRF
The following text describes a protein:
Function:
Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSDYSFRNTGSGRQSSLSVQGESMGRDTSNGSVKKNYRYRVISNDSSVDETLFGSHRDRNRKAQVEWSDHPPQRTPSSGATRKSPAIKPMLTVSPSMPKTRNKYRIQQHTPTYVDHSLFGGPLEEPSFEAPWTDKKADKRRKTPLLWGSPVQGSLEFESRSNSSMGERPGSASGSRPGSATGGRRSSMGSRPQSASGRRSATPSKPAPWK
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MELIANIVNDFLNEEEPECCSRENPVFSSIFDKPFEEVEKDIKPLLFSSICRKKSNFGTPSIIYRCKTCEKNEYSCICEECFKNGNHEGHDYEMQKTIDSFTCDCGNELAWKVNGFCKNHGKKFEGDATQLLPDSYKDIPLKVETVLITIIKYLFNSTTQKHQKEECCSSCDEECHCECKHNQSGINIIGKMLNELSEIYLLFNIFGQLMNKPTSFSIKINGFSYQNLTIGEALFVGCEKQLSEELEHFITSFQTHPKMIHYNTSLLFNFFIKLSFDEEYENGYILNDLYSQLFLQKELSSLFIQDSSFIVYLQTLQQYIHLFKENQTENEILQNNICESLRIINYVFGNSNKIMNKETLIQYLQCLQELSNVEPSLKKQYVEKITLCIIEPLLFPLKITAYYFVDNIDIGYIYEIFNDIHLFVMNHLKNYMTNSKQIHFGKSIIHNRIIGINQPISTLSPLLYFYTLILSVLMKNDLTLDISKEDSEILVEYGLMNLVFRHQYENGKWLQTGENFVSNYNLYVTPINYEFVQSDIALVQMLNSIVGPNFIIDTLKWYYNIDIPERKNDDDQHGFICTVIQLIRGFIINSNVSKEDLIRIYIIHLMISGITDPDEMSSLVPFFSTDFYSAFNYIMSQTFGGNKTIFNYVDPFFALPIEMSKALLLNTIENKESIKLNRYQVQIKDSYIISPFIHLMKQSICSCLSLIEYIESISTQKSLINFSSSLLHEIKINCDPQTKQRIDSIQTVSYFDSDLI
The following text describes a protein:
Function:
Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts together with the monothiol glutaredoxin GLRX3.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MELSADYLREKLQRDLEAEHVEVEDTTPNRCASSFRVLVVSAKFEGKPLLQRHRLVNTCLSEELPHIHAFEQKTLTPEQWAREQQK
The following text describes a protein:
Function:
Plays a role in tubular endoplasmic reticulum network formation and maintenance (By similarity). May be involved in central nervous system development. Has a presynaptic role in neurotransmission. Likely to operate in synaptogenesis by regulating vesicular transport or localization. Required for correct localization of rab-3 and snb-1 (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes to three-way ER tubule junctions.
Sequence:
MGNLFSRTKSPATELERVVLSIEDFKKRLQTISASNSSTLYYYYMGVIIILSIAMAHTWLRFDDPTKTYVACALVFGATVIVLTGRYIINCFFAWRTNRTTQKLENAITQKTVLLDLVKETLKFKEAKEILDRYEEKTEAGNTPTENSKLIHQQKQQNETLVSKTIMKPDQKRVETPVSQKPVPSKPGIAFDSMNMTPYQQRNSNATPVRPFLRQSTALDRILDYFMSDGPNCRNALICSICHTHNGMSVPAEYPFISFRCFECGHLNAAKKMGPHLPITRPPMGPKGIQHNGRAGPVPPKNQQPVVPMENPNPSTDLTPSASQHGSDSEPEKNADETAVVEKS
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSKKGTTHIEKKGEEQEESFIKVLLTSYSKETPSRLKMIDCFLIYQLITAALVLVYGFFFCHNPLNAFLAALFSCAGMFVFTMSLRLHESEEGSSKKYFVEYVFCVILLQLSVANFLG
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Sequence:
MDPGECTCMSGGICICGDNCKCTSCNCKTCRKSCCPCCPPGCAKCAQGCICKGGSNKCSCCP
The following text describes a protein:
Function:
Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.
Subcellular Localization:
Vacuole membrane; Single-pass type II membrane protein.
Sequence:
MLPKTLTIWASLASLAVAQSGQVVFAKNADGKFVHSTDDLDQGQRKIRGKFLHITDIHPDPYFHVGAVAEDKCHVDPDHKDSDYPDEDSELVWFRATGKKKHNHHKGKDHEKMPKAGYYGHPLSSCDGPISLMNATFDWIDQNIRDEIDFIIWTGDNVRHDNDNRYPRLEQDIFGYNQIVSSKFHELFRYNETRDGEGHNGGGDPQHPLVIPIIPSLGNNDVFPHNLYLAGPSFQSRRMLQIWSEFVPEAQQHIFSRGSYYFQEVITGKLAVISLNTLYFYKSNPMSDGCDEKTDPGYKHLVWLGVVLDEMRQRGMKVWLSGHVPPVEKNYEDSCHLKLAYWLTEYRDIIVGSVFGHMNIDHFVVMDPKKIEKAQSQDLGTPGLGYKSHVTDFLDVAISASHPVHTFGSIYKRNYIESVREDYSEIPGPKKWLDEYASNFAIAHVSPSVIPNYFPSLRVWEYNITGLGEEIGNPPHPPPSFRAWSDVLEEFERDYAQDVMDEIEVEWFDANSDVIEAEDNDGDDDEDENEDDPEMLTEEAIKEGVANINPETGTLASIFGGLKFWKSSTAVATSSEPESDDYDSDLDAERKKGKKKGKKGKKGKKGKKGKKKKGKKGKKGKKGKRDKSMPPKFPKDLQPGPAYIPQLFTPIGYTQYYANITQFNKEYKKTGASNFEYVVEYTTNDAPYNFEHLTVRNWVELARVLGKNFRDLDLEAEKSKSDQLWKVYMDRAFVGTGAEYLEEPDDD
The following text describes a protein:
Function:
This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity); The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
Sequence:
MGQLRIKDKSQRDGYKPNQSIAILRYAHISPLKARLVLREIQGKDVGDALYLLAVIPKKAARIAEKVLKSVIANAEQKGLDLDRLYIKKAVADDGPILKKWIPRAHGRATMVRKRLSHITIVLEEKPEGKEEE
The following text describes a protein:
Function:
This enzyme catalyzes the hydrogen sulfide production from sulfite. It is strictly anaerobic. It is regulated by electron acceptors rather than by cysteine.
Subcellular Localization:
Cytoplasm.
Sequence:
MSEEKNTAIDLKNLKAGGFIKERGKDLFTVRLRVPGGRLPVGRLKKIAEVAEKYGQGMVHLSVRQSVELININFRDFDAVVAELGEGTQKVASCGARVRVPTACGGCEYNPNGLVDTQKSALEVDEKLFGIPTGHHKFKVGFAGCPFDCPKSATNDVGFQGAVWPVLSADHCIGCGLCAKSCTEDAIAMGDNGKPLFIPANCLYCGDCLKVCPTEAWRAGKKGYTVRIGGKWGRRPLVGTLFAEFLPEDQVVDFIAAVLGWYQEKAEGQGRIRLGDVIRAQGPEALLARLRERFPAFVVNATIAPQAIATQVGKEKQAHDNR
The following text describes a protein:
Function:
Secreted immune-induced peptide induced by Toll signaling. Has a role in resistance to bacterial and fungal infections. The strength of antimicrobial activity appears to correlate with the overall level of expression.
Subcellular Localization:
Secreted.
Sequence:
MKLLSITFLFGLLALASANPLSPGNVIINGDCKVCNIRGD
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MMAAAWMEAARVSGRCWWHCCFSAGSERFLRRLWVSVTFDDVAVTFTQEEWGQLDPAQRTLYQEVMLENRGLLVSLGCPVPRPELICQLEHGGELWMVQKDLSQSTCPGERYRLEGGLEVFQPRSFRVFSSSLPPRIDVWPSVPEESSTREIQQSLGDRGKPKTREPSPWEPAVPEGASLREPTQGGLGDPQSGRTKNQGGPSVVQEGPFGRGIASQRGKLPGKVSPEHGRSGTADGVCSRGVQEPFPPGGAVPDRDSGGSGKDAMIQEEENIFKCNECGKVFNKKHLLAGHEKIHSGVKPYECTECGKTFIKSTHLLQHHMIHTGERPYECMECGKAFNRKSYLTQHQRIHSGEKPYRCSECGKAFTHRSNFVLHKRRHTGEKSFVCKECGQVFRHRPGFLRHHIVHSGENPYECFECGKVFKHKSYLVWHQQTHTGEKPYECSECGKAFCESAALIHHYVIHTGEKPFECLECGKAFNHRSYLKRHQRIHTGEKPFVCTECGRAFTHCSTFILHKRAHTGEKPFECKECGKAFSTRKDLIRHFSVHTGEKPHECTECGKAFNRRSGLTRHQRIHSGEKPYECMECGKSFCWSTNLIRHAIIHTGEKPYKCSECGKAFSRSSSLTQHQRVHTGRNPVSVTDVGRPFPGDQTSATLRELLLGKDFLNVNPEETLLQEKTSTTTSDRTYQRETPQVSSR
The following text describes a protein:
Function:
Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MRSRSNSGVRLDYYYRLVSETILAYQNPISGLLQATADQKHAWVRDNVYSIISVWGLALAYRKQADLDEDRAKAYELEQRVVKLMRGLLTSMMKQVDKVESFKLTQSPGDCLHAKYDSETGDTCVSDSEWGHLQLDATSLYLLLLSQMTVSGLQIVFTLDEVAFIQNLVFYIEEAYRIADYGVWERGDKTNHGQPELNSTSIGMAKGAMEAINDLDLFGARGGRKSVIHVHSDKIAQCQAILHSMLPRESSSKEIDAGLLSVIGYPAFAVDDESIINVTRQQILDKLQGRYGCKRFLRDGHQTAKEDPNRLYYEPAELKVFENIECEWPLFWTYLVLDGIFRGSKEQVDEYSEALEELIQRNPNGTKVMPELYYVPADKVELEYKNPGSQDRLPGGKMPQLWGQSLYILGCLLREGFIAPGEIDPLNRRLSTEPKPDLVIQVALLAEDNYIQEKMKEHGIQIQTVAEVAPIKIRPAKALCNITRLMGHNDKLGLSGNVKKEVGILSTSKLYAIHEKIIAFLPQFLDHHQFYLALDNDLLASICMNDMSYLRYNWRELGRPTMCIEVRHSMMEDDDVQRAMINIFQKFQSGYVNGVQVQLRNLSDIINTSCIEKLSYLEGFSTSGSELSQALEPSSDSSVPEPCLRGAKQLDPTASHHHHHGNHHDLQHHLHILHQEQLQQSSDEDEGGIHLLTSTPIEIPRSSSIHTSDKGTGDNPRSSSRFHGIVQRTRSIYIEESSANPDTRPLMYLLNRKASIHFNMPSIRHVESPTLTHIREQFIEQQKQQEQEHHHHQHHPKLKREGSVESYTTPYTTSLLQEDDTDSHETVFENTGIEIPLSSSPGKFHLRPDADGSFGSPMKRTPSWFEYKELEEIYKGQEAAQLVQQLQESDSLHEQADIVHYLYESKGMDWDTKINGKPGVTVKALIEELYYKSAHHKTWSVVRHTAGILCKRVEHLAKSVTDLLVRQKQVSVGLPPEPREKIITAPLPPEELETLIYEACGEDRSSAVLTQELLIYLSMFICTEPNLFTEMLRLRVGLIVQVMTSELARAMECEVNEAYEQLVTLSPFEIKDLLHHILSSREFMVNTTSHRAGTMERQLSIVSSRSNKFHGMSYLKGQISTSSSDKPYSTVSGDLMEEELTERQGQWLRRRRLDGALNRAPPDFYFKVWKILEKCQGLRIVSHFLPQHLTREMTPHEFKFALRVEEVLNRIPEQEYRQLMVECLMVISLVVENEWLHNLGGVIATDRLVAEANELFLQDQVTYDGDATLCCATPDRRGPSPLPLTCGGIAGICLHFYDTAPIGRYGTMTYLARAVAKQLNLTQHFGADAKVECKVS
The following text describes a protein:
Function:
General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress.
Subcellular Localization:
Nucleus.
Sequence:
MSSGCTSCRSKSLVRDDITGSLVCSACGLVQEFDNFDAQLGGLNGPQGTFVRVGTAGTGTLKNYKETKVYAAQTLIENITFSIGLSSSKSNDVKTMIATITENEFGQGDWFPILIGACAYVVMRKDNKLLPIAEVASIIGCDIFELGRMVSRVVDFLDLKGPEEFPEFDIVASFERTVRNSPRFTGVGRDKVATMLKQGIFLIQCAVKWFLTTGRRPLPVVAAVLVLVAELNGVDVRIDDVAKEVHATVSTCRLRYRELLESLVKVAQVLPWGKDVTLKNVVKNAPFVIQYMERKSMEKPVETRKTKGVEGVGVDLRDVVSQCLRKDVEYGTDLRSVENDSQYFEVEKNSGYARSRDDDLERMNISHECLSLMYTEFLNETSHTKSIEGDVEVRTKKTRRGFEPRPCRDWWNGKSELTKKLLLKQILEKDVGLDALPPSFVSGCRAYKRRKKRIDAAKWRVNRVLHPSRTDLVDSGDIYSSEDVDDGKRRKRRRIYDIDWEDFIIETLLLHGVNEEEIEKGHYNTLLDLHVFNGGIVPQIPSRKE
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MPSSSPSMDESRRSAVPPKEPAGRICTVCSDRANGYNFGVLTCESCKAFFRRNASKHKEIKCPFSDSCQITSASRKFCQACRLNKCFAVGMNSEWLNDLKPKSSIVSGKFKRKKPDMKNNLKVEVDDTEEDLENDDEEQISVPKALLEKLINKANEKSKDRCTCKCQCGFYPITQRLTAYEPKDTTAVNSPQDISFSHHLHHSDSFYSSSTSTLSPMSVISCAPSSHDSSGYNTSQLVTQSPTNYTVSPASIPSSITELSPQMPSQYPPMLSPFQFGVMAQMAAPANFLNFPPMPERTWTPIQAVSTVPVTETLPPNLLEQIHSKIDKYIGVLNEDEITLLEELHVQNEPLNAPLIQWHNPKSIDGVFRIIEEALRRIVNMACQLSLFRELHVDDRKNLLKSGFGELLIVRGLMAYDKSDNSWNHSFGVRGKMEVKVEVLKNPKLEEHYKAHMNLLSTFGEDVRNNEHLMLIFNAAVIFHPHVSNLRDSKRVHSTQAKYFQMLLKLLTFEYGKSRADIAYSNLLNQVVELHRVNRTLLRVFYGLDIAQLDPLIRELCSFE
The following text describes a protein:
Function:
Cell signaling peptide that may regulate plant stress, growth, and development. Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MSRSLALVYLSLLCLQTHLSISVTVPIPSVNGEIDAMLNRNGVIGEEEGEEMMPSEISRRVMMMRKQYISYETLRRDMVPCQKPGASYYACRSGQANAYNRGCSVITRCARDTNDIKT
The following text describes a protein:
Function:
Severs microtubules, probably in an ATP-dependent fashion.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region.
Sequence:
MLHPQKLEQQNYETFNKAYLKSKQLVTEGVSIDEISSNNDEQRKRIAMEKYRMGIEYFEKALKISPDKVYPEKRSEVITHREAMKRNLEATKGRLSDLEKMFPSKGNRNLQHRPVQFVSPSISKPQTAQLSSRPISSEKKNINYSNARTRSNLLKGVDDKFGGPLLNEILNQDDVKMSDIIGAETAKRALEETVILPTVNPSLFSGLRQPAQGILLFGPPGNGKTLLARAVAGECGSTMFLNVSAASLTSKWVGDAEKIVRALFQIARNGQPTIIFIDEIDSILCERNEKETEVSRRMKTEFLIQMDGMLSSKDDRLLVIGATNRPEELDSAILRRFPKRILIDVPNAAARLKLIMSLLEKTKTSFDLGLTQRQILAEWTHGYSNSDLVALCREAAMVPIRDLSRKDIKNLVSTELRPITLRDFEIAMKAIKPSTNERMLQKLRKYAATAGQSD
The following text describes a protein:
Function:
Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. Plays an essential role in the process of digit differentiation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MRRWWGALLLGALLCAHGIASSLECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCTLPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEESCPSAVPSPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINSGWRCDGDADCDDQSDERNCTTSMCTAEQFRCRSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCASDQFLCWNGRCIGQRKLCNGINDCGDSSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGRTCQDVNECAEEGYCSQGCTNTEGAFQCWCEAGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQSLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKINSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASSRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGQRIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRQRPPVTTLCAVENGGCSHLCLRSPNPSGFSCTCPTGINLLRDGKTCSPGMNSFLIFARRIDVRMVSLDIPYFADVVVPINMTMKNTIAIGVDPLEGKVYWSDSTLHRISRASLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRTVLINNNLGWPNGLTVDKTSSQLLWADAHTERIEVADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADKSTGSNVILVRSNLPGLMDIQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDRKTCDPSPETYLLFSSRGSIRRISLDTDDHTDVHVPVPGLNNVISLDYDSVHGKVYYTDVFLDVIRRADLNGSNMETVIGHGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARASDFVCACPDEPDGHPCSLVPGLVPPAPRATSMNEKSPVLPNTLPTTLHSSTTKTRTSLEGAGGRCSERDAQLGLCAHSNEAVPAAPGEGLHVSYAIGGLLSILLILLVIAALMLYRHRKSKFTDPGMGNLTYSNPSYRTSTQEVKLEAAPKPAVYNQLCYKKEGGPDHSYTKEKIKIVEGIRLLAGDDAEWGDLKQLRSSRGGLLRDHVCMKTDTVSIQASSGSLDDTETEQLLQEEQSECSSVHTAATPERRGSLPDTGWKHERKLSSESQV
The following text describes a protein:
Function:
Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA.
Subcellular Localization:
Nucleus.
Sequence:
MLALRWGLRAASGGFRPRNVPLAMAKRPSGAGEGPEENGQQAKRLKGTAGEGDAEGQNKRTPKRKIVLLMAYSGKGYHGMQRNLGSSQFKTIEDDLVSALVRSGCIPENHGEDMKKMSFQRCARTDKGVSAAGQIVSLKVRLIDDILEKINNHLPSHIRILGLKRVTGGFNSKNKCDARTYAYMLPTFAFAHKDHDVQEEAYRLSREILEKVNSLLARYKGTHNFHNFTSQKGPKDPSARRYIMEMYCGEPFVREGIEFAVIKVKGQSFMMHQIRKMIGLVIAIVKGYAPESIIERSWGEEKVDVPKAPGLGLVLERVHFEKYNRRFGNDGLHEPLEWEEEEEKIAVFKEQYIYPTIINTEREEKSMMSWLNTLSIHDFNSSTAEMEANNKNSKNSDVEGSDGCNDDSD