lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
Subcellular Localization:
Cytoplasm.
Domain:
Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
Sequence:
MDKKEILKEFSADPDKYYNVKLFQEQGFIRKSCAKCGRFFWTLNADRDLCPDDGLDTYSFIGEPPTSKRFDYTQSWKQVEEFFVKNNHTSVSRYPVVCRWRDDLYFTIASVVDFQRVMGSKVVFEFPANPLVVPQTCLRFKDLENVGVTGRHFSSFCMIGQHSVPDLGGYWKDECVDLDYRLLTEQFGINKDEVVFVEDVWAGGGSFGPSLEYFVQGLELGNAVFTEFQGELGKHTTLDQRVIDMGAGLERFAWITMGTPTAYDCCFGPINEKLFGTIGIDSDSEILRKYFTEIAKEIDHYDDLNQVRRLAVKNAGITDEQMQKMITPLEGMYLIADHLRTLIFAITDGALPSNVGGGYNLRMMLRRINATISKLNLKLNIDDLIDLHVDYLKDTYPELDEKRDDVKSILKLESARYEESKVHMKKKADKIKEKGAPSVDELITYYESDGITPEYLKEVDAISEIPSSFYSKLSDLHQSDKKKAIAELPLEGLPETETLFYQDDPMEFSAKVLKVIDDMIVLDRTSFYARGGGQEPDFGSIAGFKVINVDKHADIIVHQLEGGVPKEGETVSCKVDETRRSNITKNHTSTHIINASSRKVLGSWIWQHSAFKDDDHARLDITHHSSLSNDEVQKIEDEANDMIKKNYPVKINYYDRGTAEQKYGFRIYQGGVVPVKSVRIVSIEDKDIEACGGTHVKKTGDIELIKITKTKRIQDGVVRLEFVSGPNAFEYEKQQEQESKRKAEEAVAKEQLEKQREENKSKAREKIPVLLEKVLAGEDVESDGINTKGKLCFTASSDYDDYFHQNFGKKLVGKDSTAAFCGVFEAGPTIRVMVFSGEQSGVNAGEIAKKIASILGGSGGGDAKFAQGGGKDTSKKDEAISKAKSMILG
The following text describes a protein:
Function:
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
Sequence:
MSHQTGIKGNVELISFFGKCRDGQIRVFRVSIIKEELCLNEFARKQSNWEEDFDNLIPLLLDENQPAYLLFRLDSQNSLGYEWLFITWIPEDAPVREKMIYASTKATLKSQFGSGQIKEDILVTVPEDLTLKGYLKQKKNAAAPAPLTQAEEELALVKRTETNAHIGYDSKHQTLSGVAFPISEVGLKAMIDFKHKNHSYIQLSIDMAKEVVNLESTDQINVHTLGSRVPDDHGRYHLFRFPHSHEGDFLESIVFIYSMPGYACSIRERMLYSSCKGPITDLIENKLLITIDKKIEVEKGDELTEEFVMDELHPKKNLHQPKFEKPKGPPGRGARRLTSQKPQE
The following text describes a protein:
Function:
Promotes excretion of zinc from intestinal cells into the intestinal lumen in response to increased dietary zinc. Involved in cadmium resistance, possibly by promoting its transport from cells. Involved in resistance to B.thuringiensis pore-forming toxin Cry5B downstream of the sek-1 and pmk-1 MAPK kinase pathway.
Subcellular Localization:
[Isoform a]: Cytoplasmic vesicle membrane; Multi-pass membrane protein; [Isoform b]: Apical cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Sequence:
MTISMISPSSIRLSSDKRDSSSSNLPANIEEDTQSVSSSDSGVSADSIDHHHHGHGHGHSHGGHGHSHTHNNDDSSSDCSGAGGGAHKHSHDEKYQKGRRAEKVLWAVAALSAVFIAAEFVGGFWAQSLAIMTDAGHMLSDLLSFIISIFAIRCARLPASKRLSFGYERAEVLGALTSVIILWVLTTVLVVVAIQRIVNNEHEVDADVMLITAGVGVLFNIVMGLVLHFGTGGHGHTHGGHSSHGHAHDGKNVNVRAALIHVIGDLVQSIGVLIAALIIRFTGWTLADPICTFLFSIIVLFTTVTVMRDIFFVLMEATPSHYDLSDVKKALSALEGVKGVHDLHLWSIGMDKTAFSVHLALESPNRAMENVAEARSLIRRRFGVAVATVQVEPFDEKIDSCDTCQQQETA
The following text describes a protein:
Function:
Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.
Subcellular Localization:
Cytoplasm.
Sequence:
MDQTDTRTTVEKPSLTEEEATQLIERRYGFKVESLRPMNSYVDLNFYVKVADNNLSWPHGYTLKVTNSTYSKNGDLFEAQTKMMTFLARKGFPVPQAVPNLRGEVMSLESLPGNNNGRCSKNMVRLLTYLPGSIYYDVPMTLSIAHDAGVFLAKVQEALQDFTHPALHRPDMLWSLASLPSLNKYLYCLKDEWIKDKIRKMVQTFEEKALSRIDELLQGAVHGDFNDQNVLVEEDPADPGKHRICGLLDFDLIIYNPYVFDLAIGLMYLMSVVRDPDNPITFGGHFLAGYESVRPLTPVERDVLYYCVVARMLQSYVYGHHTASMYPENREYLLVTAGGLWTLIDRWWGTPKAEIYRQWRDIQKSIQNQPK
The following text describes a protein:
Function:
May function as a GTPase-activating protein. May play a role in transmission ratio distortion (TRD) in mouse, in which heterozygous males for t-locus transmit their t-carrying chromosome to 95% or more of their offspring.
Sequence:
MKLISSLDGSKTLNANNMETLIECQSEGDIKVPPLLTSCESEDSICQLTEIKKRKKVLSWPSLMRKLSPSSDFSGSLEPELKVSLFDQPLSIICGENDTLPRPIQDILTILCLKGPSTEGIFRKAASEKARKELKEGLNCGVSVNLKQLPVHLLAVVFKDFLRGIPLKLLSCDLFEDWMGALEKPTEEDRIEALKQVAGGLPRPNLLLLRHLLYVLHLISKNAEVNKMDSSNLAICIGPNMLTLKNDQSLSFQAQKDLNNKVKILVEFLIDNCFEIFGENIRTRSRITSDDSLEHTDSSDVSTLQNDSAYDSNDPDVEPTSGAASPNRQLEGPTPTMAGLDTRGQRDTCESSSESSVSMVVRLKSSIVQQDRRFSEPNMSPSRECLVGPTSKQKLARSEDSFTLSQDASCSEGDEAEDPFTEEVFPAVDSKPKRPVDLKIKNWTQGLASPQGHITKAFSRSSPGESLGSSPVPSPSCPKRNFFTRHQSFTTKTDKTKPQREIRKHSMSFSFASHKKVLPRTSSIGSEKSKDFSRDQLQKDLRKESQLSGRIVQENESEIQSQTSLGFSLSGTWALSVDNTFQLVDMRKPGSPPSYEEAIYYQTSGLTAYGGQTVGSMRSRMFKPSTAVPPVPSHHGGDLSEGTPGGHRLSSVTEHWTHSQTVHVSIETQGRSELHQLRTVSESMQKAKLDCLGPQHSHLVFEADQLCCARESYI
The following text describes a protein:
Function:
May function as histone H3 lysine demethylase and be involved in regulation of gene expression (By similarity). Regulates flowering time by promoting CONSTANS (CO) and CONSTANS-LIKE genes (e.g. COL2 and COL5) expression via interaction with FBH transcription factors (FBH1, FBH2, FBH3 and FBH4) at their loci to remove H3K9me2 repressive histone marks. Also modulates the expression of several developmental genes such as MYB30, TFS1, AGL6 and RVE2.
Subcellular Localization:
Nucleus.
Sequence:
MSENEIVPDEFRCNRSDGKQWRCKRRALEGKKMCESHHSQQSLKRSKQKVAESSKLVRSRRGGGDEVASSEIEPNESRIRSKRLGKSKRKRVMGEAEAMDEAVKKMKLKRGDLQLDLIRMVLKREVEKRKRLPNSNNKKKSNGGFSEFVGEELTRVLPNGIMAISPPSPTTSNVSSPCDVKVGEEPISMIKRRFRSKNIEPLPIGKMQVVPFKGDLVNGRKEKKMRCHWCGTRGFGDLISCLSCEREFFCIDCIEKRNKGSKEEVEKKCPVCRGSCRCKVCSVTNSGVTECKDSQSVRSDIDRVLHLHYAVCMLLPVLKEINAEHKVEVENDAEKKEGNPAEPQIHSSELTSDDRQPCSNGRDFAVVDLQRMCTRSSSVLRLNSDQDQSQESLSRKVGSVKCSNGIKSPKVCKRKEVKGCSNNLFLSLFPLELTSKLEISAEEVVSCYELPEILDKYSGCPFCIGMETQSSSSDSHLKEASKTREDGTGNFLYYPTVLDFHQNNLEHFQTHWSKGHPVIVRSVIKSGSSLNWDPVALFCHYLMNRNNKTGNTTDCMDWFEVEIGVKQFFLGSLRGKAETNTCQERLKLEGWLSSSLFKEQFPNHYAEILNILPISHYMDPKRGLLNIAANLPDTVQPPDFGPCLNISYRSGEEYAQPDSVKKLGFETCDMVDILLYVTETPVSTNQICRIRKLMKNIGRVRSKNPAKGRESRFDKGKKRDRLDDYSSSDSESSQHCLGAKCRGSEFEGEERESCNYSCEEESLSNTYGAQWDVFQKQDVSKLLEYIKNHSLELESMDSSKKKVSHPLLEQSYYLDEYHKARLKEEFDVEPWSFDQCVGEAVILPAGCPYQIRKNKSCVNAVLKFLSPEHVSESIKRVKELNQLPQSVKSKANKIEVKKMAIHKISEAVKEIRELTSSDSTGALRLYN
The following text describes a protein:
Function:
Essential tubulin-folding protein involved in the tubulin folding pathway. Not essential for cell viability. Probably involved in the binding of alpha-tubulin in the multimeric supercomplex.
Miscellaneous:
MISCELLANEOUS: Belongs to the PILZ group of genes that disrupt, when mutated, the microtubule cytoskeleton and produce mushroom-shaped ('pilz' in German) embryos.
Subcellular Localization:
Cytoplasm.
Sequence:
MKAESSNESFIIGQRVHSLNDSRRVGTVKYVGDVEGYSGTWIGVDWDQDGDGKHNGSVNGVFYFNGRSQSSASFVRSQNLSRGITLLQALELRYRTISTKDEEDEMYVLSAGNRRVSIQLLGGDKIQDKLSRFEELTSASLSYLGVSSLGVSSDLGSILPNLKLLDLTGNLISDWEEIGALCEQLPALTTLNLSCNSLSSDIKSLPQLKNIRVLVLNNSGLSWTQVEILRRSLPGIEELHLMGNMISTITSTSSSDDQAFNSLRLLNLDDNCISDWSEVLKLSQLPCLEQLYLNKNKLSRIFQSVNGTESSEKGSDPFPSLSCLLLGANNIGDLASVDALNGFPQLVDIRLSENPISDPVRGGVPRFVLVARLTKVQVLNGSEVRAREKKDSEIRYVRMVMSKLNDKSGEIELLHPRFYELKKLHGIEDERASAENSGPKNIASGLISITLKCVGPSMGEKPHLTKKLPGSITVGKLKILSENFFKLKSIKPRLFLQEEGSPFPTALDDETATLLDVGICDGSTLLVDEES
The following text describes a protein:
Function:
Part of the tripartite efflux system EmrAB-TolC, which confers resistance to antibiotics such as CCCP, FCCP, 2,4-dinitrophenol and nalidixic acid. EmrA is a drug-binding protein that provides a physical link between EmrB and TolC.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Sequence:
MSANAETQTPQQPVKKSGKRKRLLLLLTLLFIIIAVAIGIYWFLVLRHFEETDDAYVAGNQIQIMSQVSGSVTKVWADNTDFVKEGDVLVTLDPTDARQAFEKAKTALASSVRQTHQLMINSKQLQANIEVQKIALAKAQSDYNRRVPLGNANLIGREELQHARDAVTSAQAQLDVAIQQYNANQAMILGTKLEDQPAVQQAATEVRNAWLALERTRIISPMTGYVSRRAVQPGAQISPTTPLMAVVPATNMWVDANFKETQIANMRIGQPVTITTDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPVRIELDQKQLEQYPLRIGLSTLVSVNTTNRDGQVLANKVRSTPVAVSTAREISLAPVNKLIDDIVKANAG
The following text describes a protein:
Function:
Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs.
Sequence:
MSVDILITNLQACLISEDQPPGNVSKPFTSFLDKLSESTRTSVKRCKERCLDEAIQILKQISEEQLRGLQSEHLQLLVRLLISLQVQMVNISTACRKVDQMLQYLGKVDHQLVATETLHRFHSLFQSDQVPSQGDLQTACMFLEDSAVGHEVWRTFCVSMLNKVSELFPVLMQNESLNDGPLCYLSVKVCLQIFQLLSSEVAPLVWKENHNSQPVQKILQALMNIILGQCCNRDTRLLAGTAVAMLINTATEYQSGGAAVLSLQQIAHKDPWQLTVGVLQVECDPVRKDGVDRLAVIRGLLTCCQPQILLASLPCYSESSILIDCLYPLVYGLCEELLECHYVSFEVLTLWLKKVRECLTDLWKITGTRLFTDDNRLLVELIHIIWTNAESPVEGVPEFANRAFSLLLNLYDVDCERFGDAKKDFYSTALLKIMKLPWEAKAKYHLLCALLPYLDTDKVLDQCVEIPTHILKGLSTNQLSPCGSELYKCLIQQQRRELSQKSVSVTELDLAKHWARRWQPVLFQALMSEVSLLQSNSSTHLLPCTFQVFPSAAQHLLESLDPHTPGHLHAWACILSSYRATTGCSPWALQDSSIFETLQQALMCADEKVRLASFNLLCCSPKTNDRPTAEEMAIMKKFIPMNLNCESSSFRQHLQTGVKRFLVRIRDSCLAQIRKPKEKGKENSAHPERMQDTLEQGIEFVEWLGQLPYSNLAPGHSFQRKKTSLLLLSAVLETCTDTWSPDRKKGQPPANMKILINHAQLRGRWDFFCRSKKLLLLSCLEDSTNEIRELSTELLLKFFPPSLPVDIAEVLPMRANQLLCSPRVQEAQMGALMMKVLMYKSGEHYEGCDGGLASKTSSIIRFLLKELEDHYQTAKADMMLAARTKPIHGVLRALQRCLFEAPVSVCDAADHSLISEVLNLLEGIALLLLSTLHGDNMDSFTEKDTPPSFYDMSDAISSLISQQCGSEQTDEEDCILLSEEHRLVLTCCWVSLKEIGIFLGTLVEKGFTESKQSGEHNLLKPHLSRVSKVFKNILLNCRHWGAIEGCCVGFTKFCSCLLSCSDPELKEIPAQMLTQGLQVVQCPRSASVTRRAAGLPMLILSILAAEDASKARPLLALSVQTLMDTARTPVLDNWDQTLDLPQVCAVHTLQALVRAAPLAAAVRQFASGITVLSLTLLSSTCWAMRNAALQLYSSLCFRMLGQKSGNEESGAVQHGMTPPAFLFHYRQLQPFLLGELTRAAKGLRGPSAEAKLHLQPSLFPILTLLAQLQPAVTDTSGVFLDFSHPLLQLSASPIYSVRVMASKALVAMTPTSEHMNILLQLTAQLPGPQDICSHNQLHGRLLQIKAILEKCLCTNSRISDEWREVVSRVQDAQWLVTESQRCPLVRAVYLGVADCLREELCEDFLCQLSGKLICDLHTHPPGLQIGLSSFHQQAVHFLCGDVKWACQIWDSFSETSLDLKLSLVTWVLDGRSFKQPLLREEVQNVLLSNLKEALLSHRVEYRTAYLAALVKVMTAGGSLPQQPVLSTSHVHQPLLQCLELLFMNLEDQKRGPEFLSQALSAAGLLISQCPKASVNTSMLQRWCCILECHRAPVVPEVLRVACSEALCVTAAPLMSSMVLKIRLINTAIYLLQDQSQQVRLKAARFAALLHCARRGGSQENPNLVQVSHALLLLLDLLLEEHWDAPGTLEVLLSHLPQSDLTCVLREASAIGGFSSLYEQDEANVFAEPSVMSAHVLPHLLQLAEKSSKCSTLAHSLTSWAEENATQVLEDLKFCEKIVPENALSPAWLGLLVDPRFYTTLCGLFTRAAFLLRLLETFAPAQHLCDPSTLHTHLQTVWKLLRQNGVHFHSSLTAALAGELPPPELKQSLS
The following text describes a protein:
Function:
Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MNDQIKEQLEKEGFEIPVEDPPANYMVTTNPFGEDGSFNPVDTSALYQMSRGDSAPKSLEDKYWKVRQFYAHQLRSLQRAELIGDEITNIREILASGNLNKINELMHERHKWVEKAYYSRKDNRPICADVSCSHYALPFSKYCINHIIYDTEQKLYEKCPVCGTVKPVNGICCYCQAEATEK
The following text describes a protein:
Function:
Role in flagellar biosynthesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Bacterial flagellum basal body.
Sequence:
MTGPETLDVARDAIWTIVIVSSPLMVVGLVVGVIVSLFQALTQIQEQTLIYVPKILAIFATMLLALPFMADSLHAHMLRISSRIIGG
The following text describes a protein:
Function:
Regulatory subunit for cdc7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Specifically required during the initiation of DNA replication in egg and during early embryonic development. The complex cdc7-dbf4b phosphorylates mcm2 and mcm4 subunits and is required for cdc45 loading.
Subcellular Localization:
Nucleus. Note=Binding of complex to chromatin is dependent on pre-replication complex assembly but is not regulated by ATR checkpoint pathways.
Sequence:
MASVISVLHGQVMQQDDEPPLAKRRRCREITFAGKSFYLDVPANRQTQLLTKAIGRLGGIIESFLSRDVDYVVTGSKKAVASVSSVATRRGEKSQIQAAERKEPIHCSRGKQLLKKVVHSQECNSVLTNARSWGVTVLYVEDVVSYIERLERPPSRGIQNKTAEGRAADSTRPSLKIARLRSPFIKIEDQSRKFRPLQCTFTSFPELSFVCSDKSPFETVQTVKKKDPGDQEEEEGQRSQKPQARKRKGYCECCEETFDTLSEHLVGEHHFRFVSNPLSYKMIDDLAAQLTCDLMELPFGSPTSPEAERSSQNEDWDLDLAPGEAEPAGNEGHELGILKATRLDKDGHADCEDQGAPAYLRDGGAEEPDQRCGEIPLANIEVDVYNVCSFDQPVVTCTMELPDVSAEGKIHSNLLGSTVGDERVLQRTNGTCEPHIDLALGNGRELKHAELQKDPLTKDSQPELLSTAHEQLPTSAPCMLLEGASVVHFPSHGGTVGSQGDVTSHSAANKPHTENCPVDSTGDRHAQPAGSDALAMSCVIPTLDNGGRHVDATMQSHWEVPLGCTTDTLLSYSTTVTVGELGPEAHNPTPEQQPLLISTCSSITTVCCTDTEFKSCTVSVHSTSHSPPNQNVKSNQTPSLLEMDLANPNCHRAKRKHWDSLLSPPGKKPTSPSHCQSLTLPMWLLCQFPNYGQQVQLPVWADLCKWDGTAAAEEGTVDCSSSSTLPKLHQDSFSSESDWDAHLPSFFQNNPQQSLQCGDLRTAQVTLNESWYGKQLCNILTHDP
The following text describes a protein:
Function:
The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Recycling endosome membrane; Single-pass type I membrane protein.
Sequence:
MRIVSVFTFMAYCHLLKAFTITVTKDLYVVDYGSNVTIECKFPVEEPLNLAALIVYWEMENKKIIQFVNGEEDPKVQHSSYSQRARLLKDQLFLGKAALQITDVKLQDAGVYCCLISYGGADYKRITLKVNAPYRKINQRISVDPVTSEHELTCQAEGYPEAEVIWTSSDHRVHSGKTTITNSEREEKLFNVTSTLRINATANEIFYCTFRRSGLEENSTAELVIPEPLIVPANKRTHLAILGVIPLLLVALTIIICLKRHVRMMDVEKCITRDTNSKKQNGKNISQDREVKEKGNRRLKS
The following text describes a protein:
Function:
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Subcellular Localization:
Cytoplasm.
Sequence:
MNIGIIGTGNMGNILIDAFLETRAVKPSCLTIINRTPAKAYHIKEKYPSVHIAKTIPEVIEQSQLIFICVKPIDIYPILKKYAEHFSDETCLVSITSPISPSQLETLVPCHVARIIPSITNRALSGASLFTFGDNCSEEWQQKLLRLFKNISTPLVIEEDITRVSSDIASCGPAFFSYLLQCFINAAVDKTNITHEEATTLVSEMVVGMGKLLEKEIFTLPTLQEKVCVKGGVTGEGIRVLEEHVGDMFHKLIERTHEKFDEDLECVDQQFNKHT
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MGTNVSGDLVFLLHFILMHHFSLPLFLRAPGREMEPELFPTRIKEEEANCDYCWSPKGNSAAAAPTDGGLQAFGSGIFKIKTEESDSEVEVIPAEVSVGSHEIEENLLQVNKKEEELDYDYYLNPMENSTAALTAGENCATNDWNCDFGILPVLGTKSYFVILDTAQEPLQSTGMLVWPPESRAQTILDCGLSASSAHFPAAPKAAGFICDKCGLSFSVSGELVSHYCNHSMINMQSRQLQQKPPVCLDVVWKQKRSDNNSQAHHLLYTEEKCFPCPECGRLFPEGYRMRNHMLIHNGEKPFVCSECGKAFKRRVALVEHERVHTGEKPYRCKRCGRSYTHRGSLYSHQAVCYEEKPFACTECGKQFSQKSLYLLHQNSHTPPCADCGKIFTRKYSYQQHIKTHRRRDRRPIELAHVQ
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system.
Sequence:
MKISCRVKPISYLKSNTAEIVRDISETREPMLITQNGEAKLVVLDVKSYEEYEETLSLLKILSLGQKEIEKGQFRSADDVFADLDKD
The following text describes a protein:
Function:
May play a role in apoptosis. May act as a tumor suppressor.
Sequence:
MAHIFGSLLANGYHVVILGLDSSGKTSVLYRLKLDEYVNTVPTISFNTEKIKCKKGSAKGSTFKFWDAGGAEKLRPLWKSYTRAADAIVYVVDSTEKERFDEAKFELFKVAQRPETKGVPIMLIANKQDLRQAVGVSTIEEALTIPALRKQQHTVNVLAGCALTGEGFEDVLDTLKEIIDKHRKLLKQQKKGR
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MVVHITTDNDIGVRITLRRMLLLTLVTYIVYIAYNQRDILHINRLAVLALSFVAYLAWESIGIQYSNFTLLNDWFQYTPGNAPIVLLLIILVITLLVYLTTTQRYITPNKWIALLMLVNLIGLILFPMVNDLIPLYVIIELQSYSLYLLTGVYNKSYNATRAAILYFVTGGIASVLILLSSAEVYEATGLTNLSEISTYYSISGINTWTSFDILLIALVFKMGLAPLHAWSISVYSYAPLYITAYISIVAKVSIMSFIYLNIHLFSTQLLILAFYLSVAVAAYTPLYQVNIKSILAYSGILNFGYLLTAVLTNDNAYYIYIIQYSLTHVTIFLCILAITEYTNKPASYWSPIVNVNQLVVPNKALCIALIVCLFSLIGIPPLPGFYGKYYIIVGLMSNGLNLEALTIIVFSVIATYYYAYIIKQLASNLYNNNTNVIATPINSTLGFIISILMVILITFYMYLPTLLDGLTLLHS
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
VAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPLLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAADRDDSPTMALLLQQFKENIQDLVFRTKTGKQTRTNAKRKLSDDPCPVESKKTKRAGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGITEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
The following text describes a protein:
Function:
Ensures the proper localization of the mRNA of the bicoid gene to the anterior regions of the oocyte thus playing a fundamental role in the establishment of the polarity of the oocyte. May bind the bcd mRNA.
Subcellular Localization:
Cytoplasm, Cytoplasmic ribonucleoprotein granule.
Sequence:
MVADNIDAGVAIAVADQSSSPVGDKVELPAGNYILVGVDIDTTGRRLMDEIVQLAAYTPTDHFEQYIMPYMNLNPAARQRHQVRVISIGFYRMLKSMQTYKIIKSKSEIAALKDFLNWLEQLKTKAGPSSDGIVLIYHEERKFIPYMILESLKKYGLLERFTASVKSFANSINLAKASIGDANIKNYSLRKLSKILSTTKEEDAACSASTSGSGSGLGSGSSMVSDSVSISPRDSTVTNGDDKQSSKNAVQGKRELFDGNASVRAKLAFDVALQLSNSDGKPEPKSSEALENMFNAIRPFAKLVVSDVLELDIQIENLERQNSFRPVFLNYFKTTLYHRVRAVKFRIVLAENGFDLNTLSAIWAEKNIEGLDIALQSIGRLKSKDKAELLELLDSYFDPKKTTVKPVVKGNSNNNNNYRRRNRRGGRQSVKDARPSSSPSASTEFGAGGDKSRSVSSLPDSTTKTPSPNKPRMHRKRNSRQSLGATPNGLKVAAEISSSGVSELNNSAPPAVTISPVVAQPSPTPVAITASN
The following text describes a protein:
Function:
May play a role in protein folding in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAAAAPLPVLLLLVAVSLLVPAADAIYCDEDDCYDLLGVKQDANASEIKKAYYKLSLKHHPDKNPDPESRALFVKVANAYEILKDEETREKYDYAVAHPEEFFYNTAQYYRAYYGYKTDTRSVLIGLLLIVSAFQYINQLTSYSQAIESVKQTPAYRNRLKALEFERTGGISSKKKGNKQMDKKVEDELRNEVDLQIQGVQKPSVWNLCGVQLILLPYLIGKLLIWQICWFWRYRVKKSPYSWEDACYLTRTSLRMPANTWQNIDEFTKEDLVMKRLWEKANMERHIAEARRGSKQRRR
The following text describes a protein:
Function:
May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
Sequence:
MTTEEKINNLNDDLEELNTLLLSVKRENVKAKIQECIENINGEIIKLKINKNQMPNKITETKVQLNDPIVSYNSVQSFAWNQERNKVTIFLTVKNVHTVGEEKISTVFEERSFEIKMNDVDKKHYRFCIKKLCDKIIPNKCSFKVKKDSVHVTLVKQENKHWENLHFKESPMSKIKPPSMDEQAEPSAMLMNMMKQLYQEGDSDMKRTIAKAWCEANEKKSDFSVPNF
The following text describes a protein:
Function:
Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones. Shows a preference for naphthoquinones such as plumbagin; Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines. Preferred substrates are methyl red, amaranth and p-aminoazobenzene sulfonamide (PAABSA).
Miscellaneous:
MISCELLANEOUS: Rate of quinone reduction is higher than reduction of azo substrates, suggesting the enzyme is better suited for carrying out quinone rather than azo reduction.
Sequence:
MSRVLVIESSARQRGSVSRLLTAEFISHWKIAHPADRFQVRDLAREPLPHLDELLLGAWTTPCDGHSAAERRALERSNRLTEELRMADVLVLAAPMYNFAIPSSLKSWFDHVLRAGLTFRYAEQGPEGLLQGKRAFVLTARGGIYAGGGLDHQEPYLRQVLGFVGIHDVTFIHAEGMNMGPEFREKGLARARERMRQALETDTSLCVPLPTLR
The following text describes a protein:
Function:
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.
Subcellular Localization:
Nucleus speckle.
Sequence:
DRSIIDYRSRQSTEMAATLKVDVSIMPDFPTPPPHSSDGAGSSSSSSTSSASSTTASPSSSTSSKTHHPVADHSDHLDVSTPPPSASSLSSPSSLTTISTGGCPLLGPDYDQHGHKIKRPMNAFMVWAQMRRAEITAVSSKVHNSTISKALGVEWREMSDEAKQPYVQKAKELRDELFREHPHYVYRPRKRKVRAAPYSPRPAPLMHNTTASLPAGSACGLLLPPSSTPPPSLSALLMPLQQQQQQSTMIKQEPTADATATLSQTQFPLFPPGLLQQLQQQLALAAVMQPQQPAPAQPVGGAAAMLNPLLLANLLNPIFAQMLTQLTSTSTP
The following text describes a protein:
Function:
Able to bind (1->3)-beta-D-glucans (laminarin).
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Cell junction, plasmodesma.
Sequence:
MAPLVLYLLTLLMAGHTSASWCVCKTGLSDSVLQKTLDYACGNGADCNPTHPKGSCFNPDNVRAHCNYAVNSFFQKKGQASESCNFTGTATLTTTDPSYTGCAFPSSASGSSGSGSTTVTPGKNSPKGSNSITTFPGGNSPYSGTPSTGLLGGNITDATGTGLNPDYSTESSGFALYYSNNLLLTGFCSLVMML
The following text describes a protein:
Function:
Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).
Sequence:
MCCYLFQQRERERKGTLLTGEAYKLCETITLLDVLQIEQDIPPIGNSDDNSDDVAKSRKVRNSCMCPPGPPGERGPVGPPGLPGLPAPYYRRPRVPLSNVVFVVVIVIVFFKFQNLDESISRKMRAFGMLYSPDGQAIQLRGMPGPPGPAGPKGLRGYPGFPGPIGLDGPRGLPGTPGSKGERGERGPVGPPGFPGPKGDRGVMTGPFGVHGQHPAPSGPIGHHTTMNIGPPGPPGPPGPPGPAGRDGRHGMKGDRGLPGFDGESKIGPKGETGNPGRDGIPGARGPPGERGEKGDTAFLSTYPRGQSVSTVSSSGSQGPPGPPGPPGVCQVSQCIGVQGPPGIPGEPGRTIIGPQGPPGEKGERGERGETGDKGPPGTPGAASLLNGGKALVGPPGPPGRDGRPGEKGEKGEHGLRGDMGLPGPEGTPGKRGRRGRHGISLVAPNGTINEDLKKLLKTELMPLLIEDISELRGKNVIPGPPGPPGPRGHHGPIGPAGERGPQGLPGHSGERGERGDIGPPGLPGQPGAAESSGNQSGPRGPPGLPGPPGEKGDLGPPGLPGQPGALGLPGHPGPMGLRGPHGTEGKQGKQGPEGPKGYPGPMGPQGPPGNDGEPGIDGRPGPAGEKGDQGIPGLDAPCPTGPDGLPLPYCSWKPMDGKNDVWERRKRATLPRSESVPEERTYIKN
The following text describes a protein:
Function:
Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MYNGIGLKTARGTGTNGYVQRNLSNFEAGKKRWNKRDATDEVGSDTRLGPDAAILEHERKRAVEVKCMELRVELEDDDVADDEIEERVAQLRETLNAQLAEQTNESAASSYESGRAKETRLRHMGTHQQIQTKQHLDRRFAIAVGVESGYRQADAFNRDLQELKKSERIHQQRQAYQQRQLARASHASTQPPPHPPARCSSTHSQSTSSSSPSSPPRKRARSRSASQDSSARSSSSHASPRSPTPRTTSHVASYSSYSSRSRSRSRSRSPLSHSRSSRSRSRSRSRSRSRSRSPLSHSRSSRSRSPSRSRSPSRCASSRSRSPAHRPRRHSSSRVNPPGPPPRRPAGL