lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in ribosomal large subunit assembly.
Subcellular Localization:
Nucleus.
Sequence:
MSNIEFDLYHLSAFTTGATKEEINPDYLKQSATDAFISFFKALKECDHESDTKVKLPKPTVSIPREKPLPAEKPKTRWEQFVEQKGLKFQEKEKKVLDEDTGEWCLRYGYKRANDPLARPIIEVPNNENAEDPFTKLAREKKERVAEQKKREVRNKKRAERAIKEAAVVASLKGNKRKEQIQQALDAASHPGSSASMNQFNKVKNKVGIFEEGSSVPKIFDRNKGQKPKLGKK
The following text describes a protein:
Function:
Mitochondrial aminoacyl-tRNA synthetase that catalyzes the specific attachment of the asparagine amino acid (aa) to the homologous transfer RNA (tRNA), further participating in protein synthesis. The reaction occurs in a two steps: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MLGVRCLLRSVRFCSSAPFPKHKPSAKLSVRDALGAQNASGERIKIQGWIRSVRSQKEVLFLHVNDGSSLESLQVVADSGLDSRELTFGSSVEVQGQLIKSPSKRQNVELKAEKIKVIGNCDAKDFPIKYKERHPLEYLRQHPHFRCRTNVLSSILRIRSEATAAIHSFFKDSGFVHIHTPIITSNDSEGAGELFQLEPSGKLKVPEENFFNVPAFLTVSGQLHLEVMSGAFTQVFTFGPTFRAENSQSRRHLAEFYMIEAEISFVDSLQDLMQVIEELFKATTMMVLSKCPEDVELCHKFIAPGQKDRLEHMLKNNFLIISYTEAVEILKQASQNFTFTPEWGADLRTEHEKYLVKHCGNIPVFVINYPLTLKPFYMRDNEDGPQHTVAAVDLLVPGVGELFGGGLREERYHFLEERLARSGLTEVYQWYLDLRRFGSVPHGGFGMGFERYLQCVLGVDNIKDVIPFPRFPHSCLL
The following text describes a protein:
Function:
Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis.
Subcellular Localization:
Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Nucleus.
Sequence:
MRRTRSAVATDPREQRRSGASGGLSGGESRARRYQSRTRAGGGGGAASSQLSSKPRPKPPPRALAAAAEEPPPADTPAASVSAFDLGEQRERWETFQKRQRLSFEGAAKLLLDTFEYQGLVKHTGGCHCGAVRFEVWASADLHIFDCNCSICKKKQNRHFIVPASRFKLLKGAESITTYTFNTHKAQHTFCKRCGVQSFYTPRSNPGGFGIAPHCLDEGTVRSVVTEEFNGSDWERAIKEHKTIKNMSKE
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSNVIASLEKVLLPFAVKIGKQPHVNAIKNGFIRLMPLTLAGAMFVLINNVFLSFGEGSFFYSMGIRLDASTIETLNGLKGIGGNVYNGTLGIMSLMAPFFIGMALAEERKVDALAAGLLSVAAFMTVTPYSVGEAYAVGANWLGGANIISGIIIGLVVAEMFTFIVRRNWVIKLPDSVPASVSRSFSALIPGFIILSIMGIISWALSNYGSNFHQIIMDTISTPLASLGSVVGWAYVIFVPLLWFFGIHGSLALTALDSGIMTPWALENISIYQQYGSVDAALEAGKTFHIWAKPMLDSYIFLGGSGATLGLIIAIFLASRRADYRQVAKLALPSGIFQINEPILFGLPIIMNPVMFIPFILVQPILAAITLVAYYLGIIPPITNIAPWTMPTGLGAFFNTNGSVAALLVALFNLAVATLIYLPFVVVANKAQNAIEQEESEEDIANALKF
The following text describes a protein:
Function:
Substrate-recruiting cofactor of the CDC48-NPL4-UFD1 segregase. Assists CDC48 in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation. Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Required for the proteasome-dependent processing/activation of MGA2 and SPT23 transcription factors leading to the subsequent expression of OLE1. Regulates ubiquitin-mediated mitochondria protein degradation. Involved in spindle disassembly probably by promoting the degradation of spindle assemby factors ASE1 and CDC5 at the end of mitosis.
Miscellaneous:
MISCELLANEOUS: Present with 1050 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, perinuclear region. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes mainly at the nuclear periphery and the endoplasmic reticulum membrane.
Sequence:
MLIRFRSKNGTHRVSCQENDLFGTVIEKLVGNLDPNADVDTFTVCEKPGQGIHAVSELADRTVMDLGLKHGDMLILNYSDKPANEKDGVNVEIGSVGIDSKGIRQHRYGPLRIKELAVDEELEKEDGLIPRQKSKLCKHGDRGMCEYCSPLPPWDKEYHEKNKIKHISFHSYLKKLNENANKKENGSSYISPLSEPDFRINKRCHNGHEPWPRGICSKCQPSAITLQQQEFRMVDHVEFQKSEIINEFIQAWRYTGMQRFGYMYGSYSKYDNTPLGIKAVVEAIYEPPQHDEQDGLTMDVEQVKNEMLQIDRQAQEMGLSRIGLIFTDLSDAGAGDGSVFCKRHKDSFFLSSLEVIMAARHQTRHPNVSKYSEQGFFSSKFVTCVISGNLEGEIDISSYQVSTEAEALVTADMISGSTFPSMAYINDTTDERYVPEIFYMKSNEYGITVKENAKPAFPVDYLLVTLTHGFPNTDTETNSKFVSSTGFPWSNRQAMGQSQDYQELKKYLFNVASSGDFNLLHEKISNFHLLLYINSLQILSPDEWKLLIESAVKNEWEESLLKLVSSAGWQTLVMILQESG
The following text describes a protein:
Function:
Plays a key role in the control of the eukaryotic cell cycle.
Sequence:
MEDKYEKLEKVGEGTYGKVYKAKDKNTGELVALKKTRLEMDEEGIPPTALREISLLQMLSTSIYIVRLLCVQHIQHKGKPILYLVFEYLDTDLKKFIDSHRKGPNPSPLPPSQIQSFLYQLLKGVAHCHGHGVLHRDLKPQNLLVDKEKGILKIADLGLGRAFTVPLKSYTHEIVTLWYRAPEVLLGSAHYSTGVDMWSVGCIFAEMSRRQALFPGDSEFQQLLHIFRLLGTPTEEVWPGVSSLKDWHVYPRWEAQNLARAVPSLGPEGVDLLSKMLKYDPADRISAKHAMDHPYFDSLDRSQF
The following text describes a protein:
Function:
Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Degrades the rhamnogalacturonan I (RG-I) backbone of pectin (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MLSKATLLLFLPSWARVTYAAFGITTTSSSYVIDANSPNPLKFTVNRSNCDITSINFYGAELQYQGTGSHIGSGLGSASVSATQSGDYIKVTCSTSTLTHYFVVHNGDPIIHMATYITAEPSIGELRFIARLNNELLPNEEPFGEVSNTSGGTAIEGSDVFLVNGQTRSKFYSSERFIDDHRHCVSGSAHRVCMILNQYESSSGGPFHRDINTNNGGQYNALYWYMNSGHVQTEANRMGLHGPYSMYFSRSGTPGTNIDTSFFANLDIQGYVPDSARGKVSGKASGADSTFKWVVHWYNDEAQYWTYTASDGSFTSPAMKPGTYTMVYYQGEYKVASTSVSVSAGSTTTKNISGSVTTGKTIFKIGEWDGQPTGFRNAANQLRMHPSDSRMSSWGPLTYTVGSSSLSDFPMAIFKSVNSPVTIKFTASSSQTGAATLRIGTTLSFAGGRPQVTVNSWTGPIPSAPKDLNSRGVTRGAYRGLGEVYDVAIPAGTIVAGTNTITISVVSGSSGDAFLSPNFIFDCVELFQ
The following text describes a protein:
Function:
Negatively regulates the activity of members of the MAP kinase family in response to changes in the cellular environment. Has a specificity for the ERK family. Acts as a negative regulator in a variety of developmental processes including cell differentiation and proliferation controlled by the Ras/ERK pathway. Suppresses the photoreceptor cell differentiation and wing vein formation. Required for proper oogenesis and early embryogenesis. Functions autonomously in a subset of photoreceptor progenitor cells in eye imaginal disks. Also appears to be required in surrounding non-neuronal cells for ommatidial patterning and photoreceptor differentiation. Plays a role in the maintenance of epithelial integrity during tracheal development.
Subcellular Localization:
Cytoplasm.
Sequence:
MPETEHETCSKEWLQSQLRSLDSKDLILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLASTIKSPELKQRIQSGYKLCWFILYNGEGVPGQNQEIAGAGSLAVAMDSIISILHRRLKQDGCRVVALQDGFNNFRQAFPEWCEDDNQTHSKEIESSRNVQTDQLMGLRSLRISTTQSDSACSSSAESSDCESSSHHHHHHSHHNYNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLRLRPGSRFSCSCIAPDCNCMQTTGFMATHLANATGVSPDSGIEFDRWTPSDTGLK
The following text describes a protein:
Function:
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular Localization:
Cytoplasm, cytosol. Rough endoplasmic reticulum.
Sequence:
MGHQQLYWSHPRKFGQGSRSRRVCSNRHGLIRKYGLNMCRQCFRQDAKDLGFIKLD
The following text describes a protein:
Function:
Trans-acting transcriptional regulator of RuBisCO genes (rbcL and rbcS) expression.
Sequence:
MDLKRLKTFARAARTLNLSEAARQIHRTQSSVTEQIQALEADLGVALFDRSNRKLALTAAGTCLLAYADRLIGLADEARAAVLAAAGNASRTLDVGGIETLAVAFLPDVLARMAAIHPDIAVRVTVAQTSALHAQVKDGTLDAALFFGTRTASDDVACSVIAHAPLVLIVPSAHPLAARASAGHEDVAHERFLVTASGCGYRRMFEAAFRSRVDGEPVIAAECDSVAAIVKLVERGLGCAIVPRMVPALADAHVAIVPWHGEGATVPVSLAHRLPAPVAVAALHEALHEAMAAVEMQH
The following text describes a protein:
Function:
Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MIEDTMTLLSLLGRIMRYFLLRPETLFLLCISLALWSYFFHTDEVKTIVKSSRDAVQMVKGKVVEMMHNERLGGIDVLEAEFSKTWEYKSNNVAVYSIQGRRDHMEDRFEIITDLLNKSHPSIFGIFDGHGGESAAEYVKIHLPEVLKQHLQDFERDKENNVLSYQTILEQQILAIDRELLEKLSVSYDEAGTTCLIALLSDKELTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNLNVIISDPDILSFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPHFGAKSIVLQSFYRGCPDNITVMVVKFKNSSKTDEQ
The following text describes a protein:
Function:
Thiol-disulfide oxidoreductase that may participate in various redox reactions. Possesses insulin disulfide bonds reducing activity. Reduced by thioredoxin reductases NTRA and NTRB.
Subcellular Localization:
Mitochondrion.
Sequence:
MKSQWSNFHQIGRNSFLAASTVYVSNEFNFLNTSLLNRRSFCFAEGDRSSFVVLKSEAEFNSALSKARDGSLPSVFYFTAAWCGPCRLISPVILELSNKYPDVTTYKVDIDEGGLSNAIGKLNVSAVPTLQFFKGGVKKAEIVGVDVVRLKSVMEQLYK
The following text describes a protein:
Function:
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription.
Subcellular Localization:
Nucleus.
Sequence:
MDEAPCSANALPPFIAKTYEMVDDPSTDPIVSWSSNNKSFIVWNPPDFARELLPRYFKHNNFSSFIRQLNTYGFRKVDPEQWEFANEDFIRGEPHLLKNIHRRKPVHSHSVQNLHSVSSALTESERQGYKEDIEKLKHENESLHLELQGHKQDYQGLEMQMQVFTERVQQVKHRQKNMLSTLAQAINKPGLGLSLMPQLEMNERKRRLPGNNFLYNETGLEDNQASSSPQDSTRESMDATSHLTLNKELLDQLESSLTFWENILHDVDQNGMRRSSSVDLDASISCADSPTISYSQLNVDIGSNISGIDMNSEPNRITVPEVALQEDQVVVIGTATNRPTGVNDVFWEQFLTENPGSTESDVKPEREDFDSQKSESKTVEHGKSWWKMKSVNSLTEQLGHLTPAERT
The following text describes a protein:
Function:
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Miscellaneous:
MISCELLANEOUS: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
Subcellular Localization:
Mitochondrion.
Sequence:
MFARSTFVRLLSTSGRQLAEAEKKVSKEALMTLRKRTGYSYVNCRKALVKFGENDMENAVKWLKEAAAKEGWAKAAKLGTRVTSNGLVSVVSDNSAAAVVELSCETDFVARSGAFKDLLANISNSALSKSKSQSVSGGAKLQEFNYDLGDLTDKEGKNMREVLSLAIGKLGENMAVKRVKAYKAPEGTTLFGASHPKDGSDELPMGRFISLVALKQTSKGSISSQQLAGQICQHIIGMSPETLGEAVDTAKSQEGLSSQEGHDPDADPVVVTNIDDSETALLRQAFMLNPSQSVHEYLKSHNASVIDFVRVELGGEQ
The following text describes a protein:
Function:
Kinesin-like motor protein that exhibits microtubule-stimulated ATPase activity. Plays an essential role in male meiotic chromosomal dynamics, male gametogenesis and anther dehiscence. May play a minor and nonessential role in regulating meiotic spindle formation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSNVTVCVRFRPLSHKERKTNGDKVCFKRLDSESFVFKDEREEDVIFSFDRVFYEDAEQSDVYNFLAVPIVADAISGINGTIITYGQTGAGKTYSMEGPSILHCNKQKTGLVQRVVDELFQSLQSSESMAMWSVKLSMVEIYLEKVRDLLDLSKDNLQIKESKTQGIYISGATEVSIQNSSDALECLSEGIANRAVGETQMNLASSRSHCLYIFSVQQGSTSDERVRGGKIILVDLAGSEKVEKTGAEGRVLDEAKTINKSLSVLGNVVNALTTGKPNHVPYRDSKLTRILQDALGGNSRAALLCCCSPSASNAPESLSTVRFGTRTKLIKTTPKSISPEVDSIKKPIPDSHGQNDLRDRILNKLRLSLKEEDVDLLEELFVQEGIIFDPNYSVADIDSACQDAASQEVSLLTQAVEELKETVEELTDENERLRGELELAQEAAAAAAAARADGALLGFVPAVAISSLLRPFGFVPD
The following text describes a protein:
Function:
Probable E3 ubiquitin-protein ligase. Has a role in meiosis.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Localizes to the barrier septum and the cell tip.
Sequence:
MSRPIEIANVSSGNRRTLPALHGSSFSSRSELDNNTNSKISRRLRELVCQRMGENPLRLRQSFHETISNDSYGNSEKLVIRPCICCNSVLRYPAQAMCFRCSLCMTVNDVYFCLSGSQIKTKASTDGSQFISVEHFVETIHQTRSALQLAKQRTGNVQAIVAAGLPLRELISLVFGSPPILNKLFSVKNGCSIQSSGLNYKLIYQLYHDITNLDILITNELLRAIESLLRRPMLYCHDPADYQYLLILLENPLLNSKSKNIVNKSSSILKRILGVLSNLNEKTHHFFISCFKKQPYNNPKFFRRKVDLINKFIGQRLMETYSRNKRKHYYNNDWQIKSAAITMALLYSANSQMRLIDRSSFYCIMADFINLYHDFELWEQKINCFCFCQYPFLLSMGAKISILQLDARRKMEIKAREAFFSSILSKMNVEPYLMIRVRRDRLLEDSLRQINDRNKDFRKALKVEFLGEEGIDAGGLKREWLLLLTRKVFSPEFGLFVNCEESSNYLWFNYSHRSKEIDYYHMSGILMGIAIHNSINLDVQMPRAFYKKLLQLPLSFNDLDDFQPSLYRGLKELLLFEGDVKNTYGLNFTINLKAVEGFRTVELKEGGSELSVDNENRKEYVLRYVDYLLNTTVKKQFSAFFDGFMKVCGGNAISLFQDNEISKLIRGSEEVIDWELLKNVCVYDFYDQNAISNSISESEPSMTASKYLCHSFVSKRKIILWFWDLISHYSLKMQKLFLIFVTGSDRIPATGAHNFQLRISVLGPDSDQLPISHTCFNHLCIWEYSSREKLKKKLDTALLETNGFNIR
The following text describes a protein:
Function:
Probable methyltransferase required to silence rDNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEVPDWDEVEDGFGATAAPVPIPRAGRSQLDALKKPRRTSSSSSFGDLPPKTAKVVLGSSTGSSPCRVVATTLDWRVFDSPKHTRSSSSTTSIASVDMSDAPPPAVFKPPRPARRNRGRLAATSDGQDSDNNSDHEGSNGSSMKSPKRAARHSRQIVQDAMQGLSIDATTPTATTKSPPERAPAAPAPTTAATSNASATAAPFDYEPRVRGPRAASARLQGARFRMLNEKLYTTTGDDAFRWFKESPELFDVYHKGFATQVQRWPVNPVDRMIEFVLQKPAKLVVADMGCGEAKLGASVPNKVHSFDLVAANPSVTACDIAHVPLADEKIDICIFCLALMGTNYVDYLLEAFRILKPRGILKIAELQGDAKAHQNAWPSCEQVKSRIGESSAFVRMVQDVGFELTSEDARNTHFVDYEFVRMRTPGRRQLIRNSQQTQQVLQPCIYKRR
The following text describes a protein:
Function:
Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
Sequence:
LEDNRGLVVVLFCLPASFIFDVCLRFRNWVIRYLFSAPHQHNERVRTIQAAVRKWNDLPTENRRPMCTSRPNWLSLSTTFFQKKDCHQITVSLFDILNLDEENMIVKVEPMVSVRDVTDYLITRGYALAVTLEIGDATCGGLAMAVGMTTYSHKVGLYQEAVVSYDVVTADGSLIHVERDNEHEDLFSCLPWSHGTLGFLVALELKIIKVKPYIHLQYIPVKGKKNYCDKMRLLSGALDKLATTPDYLEATVFSKDEAVIMVGNFSYADKPGEMGKVNNVARWYKPWFYKHVETFLRTGGGDEYIPLQQYLLRHNRAIFWVVEAMIPFGNHPIFRALLGWLCPPKPAFLKFTTTPGVRAMTFTRQVFQDIVLPMTVLEKSIDIAEDLFDTYPILIYPCRIYDHGVNSGQLRPPREDQMCPGANYGMFYDLGVYGVPGKVKRKERYDSVKAMRSMESFIRQHGGYSFLYADIFMTKEEFHEMFDLTLYEQCRVKYGAVGAFPHLYDKVKPEINVFEVGRTWAETN
The following text describes a protein:
Function:
Involved in several steps of L.monocytogenes infection by both intravenous and oral infection. Probably acts as an adhesion; upon ectopic expression in L.innocula bacteria adhere better to human cell lines.
Subcellular Localization:
Secreted, cell wall; Peptidoglycan-anchor. Note=No protein is expressed when grown in liquid culture; protein is detected 72 hours post-inoculation in intravenously infected mice. Upon expression under control of a heterologous promoter during exponential growth is detected on the cell surface as a series of dots in a helical pattern, it is excluded from the septum; at very high expression levels it accumulates at cell poles. The helical pattern of InlA does not overlap with that of InlH, InlJ or Hbp2 (SvpA). In stationary phase remains outside of the cell pole and septum.
Domain:
The LRR domain (34-508) binds more efficiently in vitro to human intestinal mucin-2 (MUC2) than does a nearly whole protein (26-792) suggesting the MucBP domains do not function in mucin-binding in Listeria.
Sequence:
MKTTKIVIASLVSLTMVSNPLLTFAATNDVIDNTTEITTDKETSSTQPTIKNTLKAGQTQSFNDWFPDDNFASEVAAAFEMQATDTISEEQLATLTSLDCHNSSITDMTGIEKLTGLTKLICTSNNITTLDLSQNTNLTYLACDSNKLTNLDVTPLTKLTYLNCDTNKLTKLDVSQNPLLTYLNCARNTLTEIDVSHNTQLTELDCHLNKKITKLDVTPQTQLTTLDCSFNKITELDVSQNKLLNRLNCDTNNITKLDLNQNIQLTFLDCSSNKLTEIDVTPLTQLTYFDCSVNPLTELDVSTLSKLTTLHCIQTDLLEIDLTHNTQLIYFQAEGCRKIKELDVTHNTQLYLLDCQAAGITELDLSQNPKLVYLYLNNTELTELDVSHNTKLKSLSCVNAHIQDFSSVGKIPALNNNFEAEGQTITMPKETLTNNSLTIAVSPDLLDQFGNPMNIEPGDGGVYDQATNTITWENLSTDNPAVTYTFTSENGAIVGTVTTPFEAPQPIKGEDVTVHYLDDKGEKLADDEVLSGNLDDPYTSSAKDIPDYTLTTTPDNATGTFTTTSQSVTYVYTKNIVAAEPVTVNYVDDTGKTLSPSEILNGNVGDTYNATAKQIDGYTLSAEPTNATGQFTSSAQTVNYIYTKNPAPEKGVVEIHYVDEDNKQLNSTTEISGTIGDNYTTEPKTIEGYTLTTTPGNATGTFTTGSQTVTYVYTKNIEAAEPITVNYVDANGKTLAPSETLNGNVGDTYKATAKQIDGYTLSAEPTNATGQFTSSAQTVNYIYTKNTNTDQPLPTKKPTNTTPTKPSNLKTTEVKKASDTLPKTGDSAPWKSALLGVFLSSTALVIWKKKK
The following text describes a protein:
Function:
DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination. Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair. Inhibits non-homologous end joining (NHEJ). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle.
Subcellular Localization:
Nucleus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Accumulates at sites of DNA damage by binding to DNA substrates that mimick structures generated at stalled replication forks. Localizes to the centrosome in interphase and to the spindle pole in metaphase.
Sequence:
MRRTGPEEEACGVWLDAAALKRRKVQTHLIKPGTKMLTLLPGERKANIYFTQRRAPSTGIHQRSIASFFTLQPGKTNGSDQKSVSSHTESQINKESKKNATQLDHLIPGLAHDCMASPLATSTTADIQEAGLSPQSLQTSGHHRMKTPFSTELSLLQPDTPDCAGDSHTPLAFSFTEDLESSCLLDRKEEKGDSARKWEWLHESKKNYQSMEKHTKLPGDKCCQPLGKTKLERKVSAKENRQAPVLLQTYRESWNGENIESVKQSRSPVSVFSWDNEKNDKDSWSQLFTEDSQGQRVIAHNTRAPFQDVTNNWNWDLGPFPNSPWAQCQEDGPTQNLKPDLLFTQDSEGNQVIRHQF
The following text describes a protein:
Function:
Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.
Subcellular Localization:
Cytoplasm.
Sequence:
MKILSKKIIKGVGFIKVVPEEDDDFWHLYNLLSVGDIIKTSTHRKIVKESQTGTKVSEKRRIFVFLKVHEINYWADQYLLLSIKGRNCQESHWLSLGQFHTYEVELNQKIVIYKENWDRFHYAILDQIKQQQTLSEVAAFIMEEGVGHLCLIGSATTRLKQKVEKQITKKRSANEQREKAMEEFFKACLAALEQDSLFEQVKCLIVASPGYVKDDFYQFLRNIFQKEEKYKGKQKMLDKIFLVRSSSGYLNSLMEILQDQQVQQRLENTKQNIRKIFRAMQEVMILEKFFEQLRIDITKVAYGKKDVEFAHSLGAIQTLLISDKVARAKDPKVRRQWLKVIEEIKNKGGEVFIFSSLHPSGKQLNNYTGIAAILYVSVSFDYEDDDEDEDEQEPVGQQIHQQQHQHAQDEFKMDMVVQKKFEEFGMEDGDDVDDDI
The following text describes a protein:
Function:
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MASYKNNNLVRLCIMGDGGVGKTAVTIQFISNHFVYYYDPTIEDSYRKQCVIDDQVYMLDILDTAGQDELTAMRDQWIRSCEGFVLVYSITSRSSFDQVQFFREQIIRVLDRDDVPIMMIGNKSDLDDERQVTYQEGKDLARCLGMSFMEVSAKSRANIEEVFNETVRSVKRREESLLKKDKSKDGKDIKKKNSIIKKLNQKVNNTKTSICKMM
The following text describes a protein:
Function:
Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MSQRDSASPHPQASPGMAKQEPVLLPGREKSPPQQLQFHQEFPNNSFKRTSTSAMTPPISKKPKMAPQTFNNYNASNYGQFQASPMNSGANTPIPQQQNMPQNQQTQNQQQGGPGGQGPGQPLDPDQLSDVISAVGLDLKQEEALLQQGVPQAGYGMQQQQYGYRQQGHALLDQKRVAYTVRQLSQEAGLRFNSDRAGETALLISHACEEWLNQILTQALVLSRHRRRSRNSVHSSLSRALKGIAVKDKEREDKRAERKNLLGLDHAEPESAANPEDQQHKAANMTAAMMSSGKKKYSWMAGGVGASAGGMRMGQTGGGRGDSAIKTREAKEEPGVALRDLLGALEKERAGVEKAIVKGYAKLRN
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MSSSDIAVKRIRRQWEPEDKAWRDEALQLPWEEVSPPLHSTTLFALRNVFFFSHATAVQARTISVFCSSGNSTIVEAPTGSGKTLAVLIPLMERTVRACDAFVAAHNFPLLRRDIIGIVLAPSRVLAEQTFVVGRNLAARLPHTIRFALCDGAVQSADVVLKSLKAAARGAGTFLVTTPRDLVDFIAALNTKRPTEHPPVARSDAETSEGGRSVHNEPDEREELLAAQDEETLRRYYEKRGRRKDTSEKDTGHNVQLRGCHNERFVLVVDEADLVFHSVEMRGIVTEFVATHAYLQQPLDKRLKEERGESTSTSTNSSEKTLSMDLSFVGATVSTSTEVQTYAERACAALQSKLHKVVLNSNEDFVTQLQNRYLLCEAHDFLPILIQLMNLHSSKKHFIFFNSPKTLRFVEKLFSRLVESHQMLLCINHVFVMYEGMNERTRLDQYNAFLNHKAEVKAGATDGKKAALLSATEKKNQFYTSGWKREGRQPGGRGAILLCTDVAAFGLDVRDVDYVYHFEPPTTVQSYVHRIGRVGRMGMRGSSILILPCFSTDSSLTEAPERKSTSTRFNTLINTKSATSSIQTQQVSEADLSEERRQYLKELGERSELQPCSIPPFAPIAATVRNVISQHNKIKTLAQQAAMSMCTAPSSVEGVKSWFDPKLALHALLLN
The following text describes a protein:
Function:
Required for cellular morphogenesis and polarization of the cortical cytoskeleton. It might act in concert with proteins such as CDC42 and CDC43 to limit the region of cortical patch formation to the cortex of the bud. Required for the accumulation and/or maintenance of plasma membrane H(+)-ATPase on the cell surface.
Miscellaneous:
MISCELLANEOUS: Present with 40600 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Cytoplasm, cytoskeleton, actin patch. Cytoplasm, cell cortex. Bud tip.
Sequence:
MSRIDSDLQKALKKACSVEETAPKRKHVRACIVYTWDHQSSKAVFTTLKTLPLANDEVQLFKMLIVLHKIIQEGHPSALAEAIRDRDWIRSLGRVHSGGSSYSKLIREYVRYLVLKLDFHAHHRGFNNGTFEYEEYVSLVSVSDPDEGYETILDLMSLQDSLDEFSQIIFASIQSERRNTECKISALIPLIAESYGIYKFITSMLRAMHRQLNDAEGDAALQPLKERYELQHARLFEFYADCSSVKYLTTLVTIPKLPVDAPDVFLINDVDESKEIKFKKREPSVTPARTPARTPTPTPPVVAEPAISPRPVSQRTTSTPTGYLQTMPTGATTGMMIPTATGAANAIFPQATAQMQPDFWANQQAQFANEQNRLEQERVQQLQQQQAQQELFQQQLQKAQQDMMNMQLQQQNQHQNDLIALTNQYEKDQALLQQYDQRVQQLESEITTMDSTASKQLANKDEQLTALQDQLDVWERKYESLAKLYSQLRQEHLNLLPRFKKLQLKVNSAQESIQKKEQLEHKLKQKDLQMAELVKDRDRARLELERSINNAEADSAAATAAAETMTQDKMNPILDAILESGINTIQESVYNLDSPLSWSGPLTPPTFLLSLLESTSENATEFATSFNNLIVDGLAHGDQTEVIHCVSDFSTSMATLVTNSKAYAVTTLPQEQSDQILTLVKRCAREAQYFFEDLMSENLNQVGDEEKTDIVINANVDMQEKLQELSLAIEPLLNIQSVKSNKETNPHSELVATADKIVKSSEHLRVDVPKPLLSLALMIIDAVVALVKAAIQCQNEIATTTSIPLNQFYLKNSRWTEGLISAAKAVAGATNVLITTASKLITSEDNENTSPEQFIVASKEVAASTIQLVAASRVKTSIHSKAQDKLEHCSKDVTDACRSLGNHVMGMIEDDHSTSQQQQPLDFTSEHTLKTAEMEQQVEILKLEQSLSNARKRLGEIRRHAYYNQDDD
The following text describes a protein:
Function:
DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair.
Subcellular Localization:
Nucleus.
Sequence:
MAATVRFGLLVAMFQAMSRDRTAAKKRARLRALLDRAYGPGGRDDYFSALRLVLPGLDRERGSYGLKEAALASVLVDALGIAKDSPDAVRLTNWRRGGGFRNAGNFALVAAEVLQRRQGMTSGGLTIKEVNDALDRLAATENSVCLESEKLLLILDRSEKASILSSLIKKTNALEMKWLLMIILKDLKLGISEKSVFHEFHPDAEDLFNVTCDLRLVCEKLNDRSQRHKRQDIEVGKAVRPQLSMRVNNASSAWKKLHGKQVVAECKFDGDRIQIHKNGEEIHFFSRSFLDHSEYAPGMSKVIIENILVDRCILDGEMLVWDTVLNRFAEFGSNQEIAKAAKEGLETDRQLCCILEWIASYVLALCVNILSCQDFFFSNKRESYVAFDILYAGDTSVIHQSLTERHEILQKVVRPLKGHLEILVPTGGLNIHRPPDEPCWSILAHSLDDVEKFFKDTVDNRFFPTSPNTDELSNLSISLMIQFRFSDYSICYVLREEGIILKDLESKWEPGDRSGKWLKLKPDYIHAGADLDVIIIGGYYGSGRRGGEVAQFLVGLAVPSDDNSYPKRFLSFCRVGTGLSDEELDALVTKLKPHFRKNEYPKKPPRFYEVTNHSKERPDVWIESPDKQSVRFRKHLIYCITKCRSVIISITSDIRTIKSEVFAAPYSLRFPRIQRLRYDKPWHECLDVQAFVDIVHSSNGTTHRAADDDNDLKNVKNGGSFSMNLNDSVTHCIAAEKKATRQGRIIHYSWILDCCKEKRLLHLQPKFDPCLQPMHKFPEEIDSYADYFYWDIDISDLKQIFSNMDRAVVDSNMVHHYKKKYCADERFCFFQGCCVYFYHAPLVNADYNVISDLALKRVKQDLTMHGGQVCSILAPATHLIIVSVLQAYNFDMLYKSLPPAERRYLHDKRLQVVSNKWLEDSVEKQTRLPETTYSLKPDTLEEIEIERSEETVQPCNDKLEENEKADTSHVKHAPRKRGRPSSSASRTAKPAPRPVRRTRARRGNQHAKIDDVEPEESDHGETGLDDQIPDTDNISKMEVDSFDKDQVSARPVRRTRARRGKQHAKIDYGQSEESDPGETGQDDQRLDADYISKMEEDSSDRDQGAHPTAPRVVRRSRAQRGKWLAKIDRETGPGETGQDDKKLNADSISKMEEHAHDKDQEPPPGAQLITLDEQEPKGIKSSTTETPSSPKHERNQTVLRRDTAETTSSATCEKMEQMVDPLHAMLLDMIPSLGQMKTDVGNRVAEAKAETNPPWVGSSTSSYVAPVPQASASSASSSGVPAPHAGSSTQSTGVPAPDPTAGAPKKKKVSYKDVAGALLKDW