lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional regulator involved in developmental processes. Directly binds to the promoter region of the sex-determining factor xol-1 to activate its transcription. Its activation of xol-1 transcription controls sex determination and X chromosome dosage compensation to promote male development. Has a role in the fox-1-sex-1-mediated determination of sexual fate.
Subcellular Localization:
Nucleus.
Sequence:
MDTIININNNNQKYPQSAEEYHKVLCNYFITLQSAMQSTSRPSSSSPPSLPAVSSELLSSSFPTNAPESSSRDLAPKQNQFTINVVLFDEKKKKNPEENLPANGDQLATLRSLMMQINPSSPPSIPATSPQLPLAESENVPESSSTLKDHKFSLNTMLFNVKKNDAVKISLANQEQWAKFHEIGTEMMVFNSGRRLFPLLAYKVSGLDPHKLYCAGVHMIPDSAYKQEYDHDLQQWVNCLNQKKTIFKPTSEILGRIENGFKLMSLGIDMSDVKIFNIAIRKKTPLQIEKSRKPNLDKTIEVLIQYKYLPVIKIYELSNSGMEKKEIAQATFPETSFVTVSIYRNQKIKEMKTLGNKYCRTDRKQIVMEQRGELEQ
The following text describes a protein:
Function:
S-adenosylmethionine decarboxylase is essential for the biosynthesis of spermine and spermidine. The alpha subunit contains the active site (By similarity).
Sequence:
MPILSTEIFNEADAGFVYQSNSNDYSDGFEGPEKKLDIRFGPISKGSVKSIAGSPSKVGLRTIDKEKWQTVLDSARCTIISQTSNDHMDSYVLSESSLFVYPRRAMIKTCGTTTLLHLIAKMVQVGKECGLEVEMVVFSRKNLNQPSKQVFPHCSFSDEVNFLNKIFDGQAYVMGDVNKDHWNLYIADFRKNPTLQRTEQTFEVMMHDLDETVMKQFFKREGVSAWDTTVNSGIADLLPGSMIDDFQFDPCGYSMNGLLNEFYWTIHITPESHCSYVSFDTNVALADYNQLLAKVLNVFKPGRFTAALYAEDGAPCGDPYTAFDVNVPSYAIQNKTVHGFDGGYDVVVSNYQQLDKKVNFSNDDLIQSIESTNIDLIQV
The following text describes a protein:
Function:
Part of a complex involved in cell-cycle-dependent transcription. SWI4 and SWI6 are required for formation of the cell-cycle box factor-DNA complex. The repeated element in the upstream region of HO (5'-CACGAAAA-3') is called the cell cycle box (CCB).
Miscellaneous:
MISCELLANEOUS: Present with 3340 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MALEEVVRYLGPHNEIPLTLTRDSETGHFLLKHFLPILQQYHDTGNINETNPDSFPTDEERNKLLAHYGIAVNTDDRGELWIELEKCLQLLNMLNLFGLFQDAFEFEEPETDQDEEDPSHSKLPENKTKSENSKDNISSKRINNLQDMSLDSDAHRELGSPLKKLKIDTSVIDAESDSTPNTARGKPNDDINKGPSGDNENNGTDDNDRTAGPIITFTHDLTSDFLSSPLKIMKALPSPVVNDNEQKMKLEAFLQRLLFPEIQEMPTSLNNDSSNRNSEGGSSNQQQQHVSFDSLLQEVNDAFPNTQLNLNIPVDEHGNTPLHWLTSIANLELVKHLVKHGSNRLYGDNMGESCLVKAVKSVNNYDSGTFEALLDYLYPCLILEDSMNRTILHHIIITSGMTGCSAAAKYYLDILMGWIVKKQNRPIQSGTNEKESKPNDKNGERKDSILENLDLKWIIANMLNAQDSNGDTCLNIAARLGNISIVDALLDYGADPFIANKSGLRPVDFGAGTSKLQNTNGGDENSKMVSKGDYDGQKNGKAKKIRSQLLKNPPETTSLINDVQNLLNSISKDYENETVQYNEKLEKLHKELNEQREELANSREQLANVKQLKDEYSLMQEQLTNLKAGIEEEEESFREESKKLGIIADESSGIDWDSSEYDADEPFKVEFLSDFLEDKLQKNYEGDISKLLEAESKEQIMEQIRNQLPAEKIQSMLPPTVLLKARINAYKRNDKHLTNVLDTISTKQSELENKFRRVLSLCLKIDENKVDNMLDGLLQAISSEDPQDIDTDEMQDFLKKHAS
The following text describes a protein:
Function:
Endo-1,5-alpha-L-arabinanase involved in degradation of pectin. Its preferred substrate is linear 1,5-alpha-L-arabinan.
Subcellular Localization:
Secreted.
Sequence:
MAVIFVLFFLVSMALSARIRPSFNGTALSGTSNKHPFEPGPNTIFREEVPPSAAASGFPSAHGTELRTHDPSIIKVGSIYYSYSVGPSITIHQAFSLDGPWTEVGALLSGESVIKKGDRKAPWAANTIYINGRYYCYYSVSNSGCRDSAIGVASSAFPGPGEWTDHGLIIQSGTGEGSDVFPLNQSNTIDPNVFVDGDGTAYLNFGSFWTGLWQVPLEEELVTVKGLQDGTLDAVHLAAEPGKVWRSKLANSKAKTVSTSKTGSPICGDPTGGHPIEGGFMAYHAPYYYMWFSWGRCCEFKDPAMRSNGKEYRIRVGRSTSARGPFVDKQGIDLVDGGGETVYGSNGDVFAPGGQGILTDEFGDILYYHYLNSSVSYDFADARLGYNRLEYVDGWPVAVY
The following text describes a protein:
Function:
Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein.
Sequence:
MPPFFAEFTESVFRHFRRNEPDEENSAICSEKMSSYGAIGVDDNDTDPLLDDEPPRRLPPAGGVPIGRRRAISASQIGSIPSQSAATRQPYLFTGGLGLRDESLLSLHSEDDLHREHNNALRYRLYNRLDPGGEHLTMPDHVLPPNLFSILPFEELKDVSGKQGSIVTIFSIWNTMMGTSLLAMPWALQQAGLVLGIIIMLSMAAICFYTAYIVIESPKRLQDLSVDPLLAEFSDVCKSLFGRIGEYCAVVFSVCVLIGGVIVYWVLMSNFLYYTGAVVYESMQPNSTTIPVMENKTFTCDVYCPEQTSQWTIPQWEKQLYDAVSEMEGGETGDDSWSFDKFWTLRGTVPIYLAFALFPLMNFKSPTFFTKFNVLGTISVMYLLMFVFSKLLECGVNMDFSNPKSIHYVQLANMHFPALSGTLTLSYFIHNAVLTILRNQKHPENNARDLSIGYCLVAFCYVFIGFTFFAAFPVQRSCISDNFLNNFGAGDVLSSTARLFLLFQMITVLPLLMFLVRSQLFYAIFGQTWPGAIRVIILNVLLIAVAVGFATFYPNVGSILRYVGSISGLVYVFALPAMVYIKQSEAAGTLTPMKKYAHYGIIVIGVANLIAQFVI
The following text describes a protein:
Function:
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (By similarity).
Subcellular Localization:
Cell membrane. Cytoplasm. Nucleus, nucleolus.
Sequence:
MQSAMFLAVQHDCVPMDKSAGNGPKVEEKREKMKRTLLKDWKTRLSYFLQNSSAPGKPKTGKKSKQQTFIKPSPEEAQLWAEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKSLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT
The following text describes a protein:
Function:
Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
Sequence:
QVCFENRPENNTKMEDFNVRLTEAANRNFQDQLPDVCRRFHEMLTKEDFSPDALAKVRSFIKESCKRIVEEVREKRERKRENNEKKASESDKTKCDDEGSDSDDDVTTELESNPHINRMIDVLKPELRSVVECCNTVRAWVQLQVPEMQDGNNFGVEVQGEVLEEVRRVESGSQAFMEALSLYYLARAEVAGKFAKHTGIQDYVYALQELDVKEFHSLRLIVREVRNSCVTMLDMLNKNMDKILTPRSNTGNMLV
The following text describes a protein:
Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Sequence:
MAPKRSGYESLVNCYCLLMMMAIFTISRAQYDGFFGGAIQFWEYDDNIFPVRLRQQQRPVSAVVDIKGTTNFPGVSGQIHFTQTTTGGPVIVRGTIQGLTPGLHGLHIHQFGNLSDNCNAAGPHFNPYNKDHGGLDDHVRHVGDLGNVDAMGDSFADLFLFDHLISLSPKSDRSVLHRALVVHEKADDLGLGSHADSKKTGNSGSRVACGIITLTPSRIPSYFKHRRRRTVPWLKLFLNSLSRPIFGLDMEQHAVPEPGSIKMDMTHEPGIKKEKRVAASQARSSHITREGI
The following text describes a protein:
Function:
Involved in biosynthesis of fatty acids in mitochondria.
Subcellular Localization:
Mitochondrion.
Sequence:
MRKVLITGGSSGLGKRIAQIWSQKGHQCHIVGRNEFHLKETLQSLSVAKGQQHTLTIADVQSDMKNLKSIFESVEIDTVVHAAGVLQSSLCVRTSEKEIDSIICTNLVSAIKLSKMAILEWFRNKNSERDRLILNISSRLSTYALPGTSVYAASKAGLESFTKVLAAEVASKGIRVNAISPGYVDTPMLSSQIRAIAEKKVPIGRLASTDEIVDACTFLLDNRYTTGTILPITGGL
The following text describes a protein:
Function:
May play a role in the establishment of transcriptional silencing boundaries, preventing the propagation of heterochromatic silencing.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNNPTSDDRLRFQQKCHKSMLNTGAIFKNCKLRNGDVLQEVTESLTEDSEFNYIVNESQNVSTRLIFWNKWIYILCANTSSNITATRIFRLDDDQPWNLESLVAEVCPVDTDNRLAEHAARTAKDTSANELNYESYQEKSRAPFGFAGPFGAMPGSQPMFPSIGASDLYPAGIGGSDMGNDGGMIPTFNHPIFHPENRSRNEQASANRTNIPPGARYDPTGPGDFRGFGRDERKPQFPFKGPRSQFPGEPDNDDFMPPGSSDMFM
The following text describes a protein:
Function:
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (By similarity). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (By similarity). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (By similarity). May counteract a default induction of apoptosis in G2/M phase (By similarity). The acetylated form represses STAT3 transactivation of target gene promoters (By similarity). May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity). Essential for the maintenance of mitochondrial integrity and function (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Midbody. Note=Localizes at the centromeres from prophase to metaphase, at the spindle midzone during anaphase and a the midbody during telophase and cytokinesis. Accumulates in the nucleus upon treatment with leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor. Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody. Colocalizes with AURKB at mitotic chromosomes (By similarity).
Domain:
The BIR repeat is necessary and sufficient for LAMTOR5 binding.
Sequence:
MGAPSLPRAWQLYLKEHRVSTFKNWPFVNGCSCTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDNPIEEHKKHSSGCAFLSVKKQFEELTLSEFLKLDKERAKNKIAKETNSKQKEFEETAAKVRQAMEQLAALE
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MSKNQVDFCAAITKDYFGPEVARVAQFLARNGSSVFRCLCSKGGFPEKMLKKSLWVLIQHNFVDVTVTQSGLTVYKINLNYILQKTRHFKFMYMVKCLYGDESKMIVEEISRHGKVDPCDVITSLSSQTGASRETLQEKWNQMKGDSLIVQCPLLDSSELQQTNSTPHKSCTTTNNNGATGMKARKRKNVVDSDEEADDKNVEPASKKFKSEGLWKLNSSKFNELLRNQIIIETMAMKIDRRSADIVKAILRLSELSQLQKNVANRFRTFGVTCNEIFSCLKKQMTSLTLLQLDQMLKILLEDANSILKYALSDMHVCIRWRDGPTAAVHCRSLPETSNPGDAFLHSSFVMKDGDSGGGVYRIDFQQAFTELGLAHVTSVIQERYGSKSLRIFRVVMLKKKIEQKQIEDLVMMDPKEAKELLYKLLEDNILFLTLYINVYKSLDGGLGVKASGKERVQVKD
The following text describes a protein:
Function:
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses.
Sequence:
MSSAAARALTSVSRAAFSWKPTGRPQQTLAAAVSRSGVGLHSGARVTATLFPTQAGEGRYFLVEGEEEAKVAAEVGNAEPRSQLCTTLRRGEGAHTRVRTVEHLLSAMEALGVDNCRIEVSGGDEIPLLDGSAQEWVEAIQSVGLCAAEDANGLKLDKLAPEIHEPVYLGKDDCFIAAFPSSQIHITYGIDFPKVPTIGCQWVSTFLDENIYSSKIAPARTFCIFEEVSSRWVGPGPWQCCQQHLPPHVDLDHPCVLVPAMAPADLEADDVRVVQANDGGLQVHVWETLISRHRPELLTVRGSSSKAPSSVALGTKICLFSRPSGPGVLKSIARPLNCR
The following text describes a protein:
Function:
Involved in tolerance to thiabendazole.
Miscellaneous:
MISCELLANEOUS: Present with 573 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MNMDSGITSSHGSMDKTQKQSSEWAANQKHNQRVENTRVLMGPAVPAMPPVPSNFPPVPTGTIMSPQLSPFPDHRLRHHPLAHMMPADKNFLAYNMESFKSRVTKACDYCRKRKIRCTEIEPISGKCRNCIKYNKDCTFHFHEELKRRREEALNNKGNGKSVKKPRLDKENKFKDENFDIAVRSRNTSSTDSSPKLHTNLSQEYIGVSAGKSASDKEDTWPDFVPIDRTVLEKIELNHTKVAGKVFVLEEICKNMKGTIEKLAEKSKIDVIDKEYMKRPKRKQYSKALLTKQKMFHFRQNVLSHLTDEEFLSPINEMFTTTFKYSILQTKLVLDFSFRSASSPSSDNILYPLPRLAIAKRLLKNIKCPSLASLLHIVDVDQCLQFADVHFDPAKGRLTSSQAFLLNICLCLGATVTNFEEKQELVDEDNHETYYFEKFELWRLRSFTFLNSVYYYHKLSVARADMTALKALLLLAKFAQQKISASSAVKVLSVAIKVALDLRLNLHSTYEDLELDEIIKRRRLWCYCFSTDKFFSVVLSRPPFLKEENTDVLTDESYVELFRDKILPNLSIKYDDSKLEGVKDIVSVVNLLANHLEYVPYIQSYFLSRLSLIESQIYYSCFSIRTTLDDTLDEIIENVLENQKALDRMRDDLPTILSLENYKENMRILSLDSSKLDFEVSCCTTILLHLRWYHQKITLSLFVISIIGDNLDQRESSRHDIAEIIRRSRLDFKRNCIEVLNILKDFEYYPTVQNEFLYFSLTTVFSMFLYLSEIMVNDEHAMETGYIIGLLRDTHTRMLGSEERCLSVHNLKWQTSLFFYTFFLRSTMEKFNLTSKYAKFYAFDSNYYEGVLNRLVKHTRESKDDMVELLKTSFINKEKMAAFGSFVTEDQEKMEVSFNIFNEITIQDLNFLQFSSIPKLWENKTLEPGEEYHHSNGTNTDNNETTGADDTDDNNNNNNNNNKNGNNSSSTINNNNNNYSNSNNNDNDNNINDDDDDDDDDDDDDDDDDDDDDNDDDYSNNGADDDEEDDDYDRSLFPTGLASLLDASYPERTANDYRDENEQSNKLFEKIEGHLEHGVFFYDRDFFFKNVCVKM
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (By similarity).
Subcellular Localization:
Cytoplasm. Endosome. Late endosome membrane; Peripheral membrane protein. Note=Colocalizes with F-actin.
Sequence:
MSVCDSSIRPVSAMAWASNTSTCPGHFTLISQTEDGASANFSRGFVRSGYFLCYSKDLSGGMVVADVQVITDKGTILHGYCYIPEYLEQKASVAKKKRVCVRLVPVGSVTTAVLDLKLTTKHKSMVQQYTCLGDMNGFVVWCLKGPFSPPAPQAKPRRVSLDIRSLSLDGPAPPQPLKPSNPPEAPPKVSRRRSKLDLPAGGVCDSSVCSGISAMDGVPFTLHPKFESRSSSTKVSVITLSDIRIKSVQDIENEYNYTFTVEELAAKRIRPSLSG
The following text describes a protein:
Function:
Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.
Sequence:
MPTQCLISFGSNLGDRRVVIAEAARRVAESGVIAEPCTDLSGGSAEEPVQRLRTSRLFETPPIGGPGGQSPFLNAVAAFATEASAAEVLDVLQHLEIDLGRKRLIRWGARVIDLDVVLHGRLAGSASTAGRRGLIGGRGPAGSAKALVVPHPRYTARRFVLEPACDVAADFCDPRFGWTIRDLRDHIAADVPSIALVGGDSKLRQIICQRLSSEHGIAVIDPNRPDAAKGLQQWVAADPPLALRDSKEIDQDTSPTSQCLPRLLARIQHTTEKDRWPAPHQIWPAGWKWPEYRLEVDDLDWAIGELASAMDSMRCEIHPTTDDGRWW
The following text describes a protein:
Function:
Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs.
Sequence:
MGAEREARACAAFYGDAGRCGPGRAALRCVRCLRQFAGSTARRCRDEHLEEALQLAQALGKELQALGEAEVRPLLRCVLAFQLEAAGSSSAFQKLEQIVTQLAVGQEAVLVQEVGTLLAGLAPHGEVLSPEDLQAVCMFIEESRLGRHHWQQNMAPLLQRLAHTLSYVLQGQPAPSGTWGCLAVKACLQLFQVMPKDVAPLVWSAAAKNEALQRILGLLLEAVAGKALSKDVRLLAGTALSMLLNTAPQPESGARAALTLFQLMDRGAEELRVGELAVEAHSIPELDGLERLALSRGLLTCCRADILCCRLEGSTCQACLLLDVLFPIVCTLSKEQKDCHYHCFQVLVLWLRRVQENLPELWHLRGGRLLAEDAKLLQKLTQLVWDNAEAPVEGVSEFIQSSFRVLLEIYHLECQHFEDQERPLYQQMLQRAVSMPWQIKARYVPLCALVPYVGSQQVLDACPMLPQHLLSCLATNHLCPTATELYRALVRQQCSQGQGDVQAELWAQHWLPLLSRALRSPLPILHSNAANHLLPWTLRQLPAAGTLLAAQFSGADTAALRAWVSLLRVQRSTAGVTPLRAEEIARLQACLRAREEGVRLAALGLLCGGPGHSLAGTEERLLREFLPLNLNCHTSAFRQLLQAALRKVLGRLRDGALARLRGKDPREPRGEGVGQPARAVDFVEWLLQLCISSLTPWANYQRKKTALLLLTAILETCTDTWSPERKKGQPPRTMATLLGHARQSGCWDFFSRPNLLALLGCLQDSTNEIRDTASELLIRYFPATFPETLTPALLRLAQDALSSPRVQEAEAGAVLMKTILHKSDSSTLKLLALEAKTAQTLTNRSLYFTQHLLRVLQAQLATAQQNLLQAAAVAPMHGVLAALRRCLLQVPEVITCMQTAESAQAWQELLSSLVDTARDITSLLLGALQSQQGPEAEQQVAAPSFADMGNAIGSLIMLGKGQREEEEDSVLLSEEHSLILTCCWVSVKEVGLLLGGLAELLLSSPGAKHLLQLASLQTAATVFQEILLRCRHWGAVEGCSMGFTKFCAALLNHPNTELQAIPQTILDQGLEALSGPRSSSITRRAAGFPMLFLCIVSGENPAQARPLLTRCIQTLLALATMALPQDWDQTLDLPQVCALHVLQTLVRGAGLGAALLRHATPMVALALRGLSSPCWAMRNAAIQLFSALTTRLLGQKQSSTEGCLVEGLSLPAFLGQHPQLGAVLLAELEAAVPGGPHLRPTLHAVLTLLAQLQPGPDDPSSPSTHFLEPLLELAGSPIYAVRAMAAKALIPVVPPPQRPALLLQLAQQLPAPGGVLSHNALHGRLLQMKALLAPNPGTARLPAEALHPVALQLEARSWLLSPAQRCPLVRAAFLQVLTLLPASLSPGFTQSIWDAVSAELGGLTLGREPGCAELQVGAAVLHQTMARFACSEAARLADSKRIHTVCSLLQHPHPDVRLAVLSWVTDGKRAQCEELERALRLTLLENLQSVLQDRGNKEFLRLYLEALVHLCRDCPSWSQEASQKLQGSALACVETLLLVMEMERPGPELLSQALCAASLLLTVGFGDEDALLVQRWCTMLEACGRPVADEVLRLAAACSLQTAGTEVLRRCRGAACPWLIPMALRVINMSIHLLQDEDPDVRHEAAGFASLVQHGLGQPGGDGCIFVQGNVGLLSLLQLLLDEFGHHPETFGSLLQHLPQPNLRAIVEDLEADTPHSLYKEDEPNVFAEPAALAQQLLPFLVQLLEKAPSSALHWLQAAGPSVLQDLHYCQQRWSHESATRCWMKALGCAVLRAALAVLLVRAQLVAHALRLLGEEHGAVLGLDCGAQELEQELVLVQGLLAQHGLGSAPQQSPAPAEQGEAHGDG
The following text describes a protein:
Function:
Acyltransferase; part of the gene cluster that mediates the biosynthesis of the glycolipid biosurfactant ustilagic acid (UA). UA is a secreted cellobiose glycolipid that is toxic for many microorganisms and confers biocontrol activity to U.maydis. UA consists of 15,16-dihydroxypalmitic or 2,15,16-trihydroxypalmitic acid, which is O-glycosidically linked to cellobiose at its terminal hydroxyl group. In addition, the cellobiose moiety is acetylated and acylated with a short-chain hydroxy fatty acid. UA biosynthesis starts with omega-hydroxylation of palmitic acid catalyzed by the cytochrome P450 monooxygenase cyp1. Terminal hydroxylation of palmitic acid precedes subterminal hydroxylation catalyzed by the cytochrome P450 monooxygenase cyp2. Sequential glucosylation of the hydroxy fatty acid is probably catalyzed by the glycosyltransferase ugt1 (Probable). The cellobiose lipid is further decorated by acetylation of the proximal glucose residue and by acylation with a short-chain beta-hydroxy fatty acid at the distal glucose residue (Probable). The acyltransferase uat1 may be a good candidate for catalyzing either acetylation or acylation of the cellobiose lipid (Probable). The fatty acid synthase fas2 may be involved in synthesis of the carbon backbone of the short-chain beta-hydroxy fatty acid esterified to the cellobiose disaccharide (Probable). The secreted UA consists of a mixture of both alpha-hydroxylated and non-hydroxylated glycolipids; therefore, alpha-hydroxylation of the long-chain fatty, catalyzed by the fatty acid hydroxylase ahd1, occurs late in UA biosynthesis and may be the last step before secretion.
Sequence:
MVVKRILPLPRPAGLAPPTEVPLDGQDLAMPKMVMHCIWFFLASSQPSLESTSLQELEQAFTLGMQLFLARFPAAGARTRHDKDTARWYLEYNDQGADLEVIQLDRPLQDDWKALDGKCDSVFAPRPVMIFDDDASIFSIKVTRLSCGSVAISTSTHHWLVDFVGYIDLMEELSHCVSIFLNDPNAQINIDEGATKFDWSRDLLAYSKQLEPESIPSATWFTERGSPPQMTRAPSSCHYASLLFTQESLEKLKRSLAEWALETAPTTATDRIVPSKDNWIATNDALHALLWAAITDARGLDLNATTQLHTPLDGRRLLSSLSSADSQSRGKYIGNVHPGHVFPLPSSVVSAKDRSGLFNLAWLIRTQYLNVTPGQMSAIIRHHNYTDAETFGPGRLPKCTSMFGNDVTISNVARIPVRQRLDFGEKLGKPYTLTVVGMVPVTLNGLTLDSADGTCFIIQAPAEWTSKEAVLQHQPRSGDNQAPGGMLVYVGMRSEEMDKLLQNSLLQEFALVL
The following text describes a protein:
Function:
Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.
Subcellular Localization:
Cytoplasm, cytosol. Endoplasmic reticulum. Golgi apparatus. Mitochondrion.
Sequence:
MASRESRAVVRGSAHKRSRSKDLDPPSMSEKLNVLVCGSDGSLKSSISELILQHTHRRSESVRTDVINVLELPALFNTGLSEEEVMRQTLRCVSLCHPGVHAFLLIIPDAPLNNEDRAEMEEIQKIFSSRINKHIMILIMQNSEHQTAELNEETQAVIQSFGGRHHYFSPETQVSTLMENIEQMLEENRGGVYSTETFLEAQMSKLVKYEKMKKKINSLETHVLSQGSRVNTEDEVRIVLLGKTGVGKSATGNTIIGRAKFTAETSHQSVTKESQRETCEINGRQVTVIDTPGVFDTELTEEEIQREIRHCISMILPGPHVFIIVLSLGQRFTKEEETSVKIIQETFGENSLMFTMVLFTRGDDLKNKSIEEFLGKPGSPLMNLIEACGHRYHVFNNNQPEERTQVSDLLEKIDNMVKANGGSFYSCKMFREMEREKQEQQMKILMDRVRETEEEMKKLEEEKDRMKMMMEEERQKQEKERKRREEEFREREERYKRLIRGREQKENELIEQMKRMQKQKLEERLRREEEKQKSKLHPRLQNPVSDQTADLNVVLLGKRGAGKSASGNTILGRQVFISKKSARPVTRDVNVESGSFCELPVTVYDTPGLFDTKLRDEEIQQMISEKVLQKCSSGLCVFLLVIRADRFTEEERKTVEKIEKILGEKHQKNTWILFTGGDELEEENTTIQEFIEETEELKTLVQKYEHRYHLFNNKRKMKRTSVQVKALFTKILKNYSDTAAGAENLLRKIPANIEPVPRVSSPPSRRIVLVGKSGVGKSAAGNTILGQKEFRSVRRMSSVTCKSSAAQTTVSGRSVSVVDTPPLFDTQMNPEELMMEIARSVYISSPGPHAFLIVFPVNMRFTERELQILQKIELMFGEEVLKYSIILFTHGDLLDGEPVEKLIEENSGLRSVVQQCGGRYHVFNNRDEENREQVEDLLQKTELMIQQNGGGHYTNQMFEDAQRFRREEEEQRQREEEERKLQEEKQIQEEIKRVRKETEERVRAEMEAKNLKAERPSEEEQRRREKQRQKEIEREKKNTKERVRKEMQAVNDIEERIKGEDRVRKQSQNCVCS
The following text describes a protein:
Function:
May mediate the reduction of outer membrane cytochrome b5.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MLVPWAPIAATSVVAAAASSYYFSNMAISNDAKTATLKGDDQWVDLKLKSSKDLSHNTKALIFELPTPDSTLGLTTASALLTKYVTPKGSNVVRPYTPVSDPDSKGEFELVVKSYPEGKMSKHIHELKEGDTLSFKGPIIKYQWQPNLHKEITLIGAGTGITPLYQLISAINKNPEDKTKVNLFYGNATEGDILLKDEIDAIAKAKPQQFNVHYFLDKPSDNWKGENGFISEEFIKGNSPAADSDNVKVFVCGPPPFYKAISGAKVSPTDQGEVDGALKNLGFNKDQVFKF
The following text describes a protein:
Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MSGTAQIIITVLDELLLFSVLFLPSVVGQVSYTVPEEMQTGSLIGNVAHDLGLDVKRLKSGNGRIYSGDSRNYVELNVDRGALLLKERIDREVLCGETTPCALHFQIVLDNPMEFYSVTVEIKDINDNAPTFEKNEIKFVISESAVVGAKFDLERAIDLDEGINHVQSYVLKPSDNFSLKLRSQADGSKNVEMVLQKALDRERNEFIPLVLTAVDGGEPQMSGTMQILITVLDVNDNAPVFTQPVYKATVAENALKDSVVVSVKAEDADHGLNGKIEYSFTNALDDVRRIFEVNEENGEIRLIGRLDYEKKKHFQINVRARDNGGLTDSCKVIVDVTDINDNEPAIKIMSKSTVISESASAGTVVTMINIQDPDSGDNGKVQCFINDNIPFILKLTSNNFFSLQTDSELDRETASEYNITVTCSDEGVPSLSSSVTLTLQISDVNDNAPVFEMSSYEAYIVENNTPGVSIFTVKATDADWKQNARVSYILEDSSVNGVPVSSYVSVSADSGVIHAVRSFDYEQIKDFRFCVKAQDGGSPPLSSNVTVKIQIQDQNDNPPQVLYPVQTAGSVVAEMVPRSADVGYLVTKVVAVDVDSGQNAWLSYKLQKATDRALFEVGSQNGEIRTVRQVTEKDLLKQRLTVIVEDNGQPSRSATVIVNVAVADSFPEVLSEFTDFPHDKDYNDNLTFYLVLALAVVSFLFITCLVVIISVKIYRWRQSRILYHSSLPVIPYFPPRYSDTLGTGTLPHTYNYEVCRTTDSRKSDCKFGRAGSQNVLIMDPSSTGTMQRLQSEKSILDEPDSPLESPPSPAASLSPYRSLMPTL
The following text describes a protein:
Function:
Functions as an activator subunit for the CBK1 protein kinase. Part of the regulation of ACE2 activity and cellular morphogenesis (RAM) signaling network. Required for coordinating polarized cell growth during interphase with the onset of mitosis. Required for mother/daughter cell separation after cytokinesis. Also has a role in the prevention of nuclear export of ACE2 from the daughter cell nucleus after mitotic exit. It coordinates ACE2-dependent transcription with mitotic exit network activation.
Miscellaneous:
MISCELLANEOUS: Present with 2250 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localizes to the bud cortex during polarized growth and to the bud neck and daughter cell nucleus during late mitosis.
Sequence:
MSFFNFKAFGRNSKKNKNQPLNVAQPPAMNTIYSSPHSSNSRLSLRNKHHSPKRHSQTSFPAQKSTPQSQQLTSTTPQSQQQEASERSESQQIMFLSEPFVRTALVKGSFKTIVQLPKYVDLGEWIALNVFEFFTNLNQFYGVVAEYVTPDAYPTMNAGPHTDYLWLDANNRQVSLPASQYIDLALTWINNKVNDKNLFPTKNGLPFPQQFSRDVQRIMVQMFRIFAHIYHHHFDKIVHLSLEAHWNSFFSHFISFAKEFKIIDRKEMAPLLPLIESFEKQGKIIYN
The following text describes a protein:
Function:
The alpha isoform interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. The beta isoform does not interact with XRCC1 and may be specifically involved in the completion of homologous recombination events that occur during meiotic prophase.
Subcellular Localization:
Nucleus.
Sequence:
MSEDKSGSFYSMYKLCGQLEKESSHSGKTQLIKSFCNVFKGDLYLLAKLMLCKEDKRVFRIKDKAMLKICSHIWDCDLDDMIEDLDNGDFTETCKKFYIEYGKYPEKSTLTLKEVDQVLDSLTVSGKFEDQVKIINKLLKRCTPFDFRLVCRIIDSDLKINTGAKFFLDAFHPQAYDAFKKANNLKGVIEKIQQHDFDNDNGDGDDGDGDDNDDDDGDGDSDSDKKKKKSSGGSGSDSGSKKKSKSFEVAIKLMTPIKPMLPKAVKTVEGVVKSSECFYAEIKYDGERIQIHKDGNQFSCYSRNLKPLMPWKVDEVKPYIPKSTKAQQMILDGEILLMDTKTSQPLPFGTLSAHKKNGFKDATVCVFLFDILYLNGKSLIHLPLKERREILEKNVMVVKNRIEFSEVTIVNGASEKSKLTALLNRVFKEKLEGLVIKDAMSEYEPGCRHWIKIKKDYIHGMADSADLIAVGGYYGSGSMGGLVTVFLMVCYDKQNKIYKTVVKASGGLDDNMIAKLQPKVTSTMTKISKEVSKIPYWLDCPKQYAPDFIVKDIKQAMIFEIESAEFTKSDHHTTGYSMRFPRILKIRHDKDYKTATTLEELVEIGKDIKIVPVGKGDNNSPTTTTTTTTTTTTTTSSKLIKKQQLSDDDDDNDKDSKQQQQEPSKLKFVSDDLLDPFNDKSDDESNKIFILNYVDNSGIWNEKGLSGAIGKKWPSIPKSFSQGDSNIIKSGEIRVEKVKDDSISTNKKVFICNLSCIIPPKSKKESYTFSLKEFKSAIKEAKGAINQKKASVHLAKPQFTSPSWSELDEVLTKELYNSGIKVFVHSISKSSPTTTSPTTTSPTTTSPKITSPSSSSSPSNKLSPLKRGRDEKLEHEIIKDIEPSLPIFEDVNAVIDSKTIDQVDVKRLINSIKTMGGRVSDKWQQVGIGKTTHLICNGMSDLYLHVDRLGGTIVLPNWVDQCFGSDKLLPLHEDYIYFNKKDHPDYSQSSSSSSMSIEEEKIVVTTTSDDPSEGNQQQQDKKVIKESKIIQSKDHSSTTTIDTKITITSTNNNNNGNDNNKTRKKQHLLSIFQECIIFLHDNVNDRETLKRYIIAYGGDISDSVNDKTTHLVASLPNNFSNVKPKDLFKSIINNNSKNNNNNNNNNNNGIIVNSLWLWDSINMSDLLDVKNYKLF