lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts on leucine, isoleucine and valine.
Sequence:
MDGIISGLLPNVISPRCSPSVQGALQGRGAFPAGNHLEIAPNSRAILRHHAKGRPVMAEIKKAIEYSPSWTFFEGKWHDGNVPIMGPRTHAAWLGSVVFDGARAFEGVAPDLDRHIARANQSAINFGLKPVVDPGTWLTLANEGIARFATNAELYIRPMYWAENGSGGGVLFDPETTNWCLCIYEAPMPKPVGNAITLSPFRRPTAECAPVEAKAACLYPNNSRALAEAASRGFQNALMLDMLGNVAEFGNSNVFMARDGVVFTPVPNGTFLNGITRQRVIGLLRADGVTVVEKTLRYADFLAADEIFSTGNFAKVAPVIRIDERELKPGPLYTKARKLYWDFAHAVKLAA
The following text describes a protein:
Function:
Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the biliverdin in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.
Subcellular Localization:
Cytoplasm.
Sequence:
MIIVTNTAKITKGNGHKLIERFNKVGKVETMPGFLGLEVLLTQNTVDYDEVTISTRWNAKEDFQGWTKSAAFKDAHSHQGGMPEYILDNKIAYYDVKVVRMPMAAAQ
The following text describes a protein:
Function:
As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. dgt2 binds to microtubules in vitro.
Miscellaneous:
MISCELLANEOUS: The name 'dim gamma-tubulin 2' derives from the decreased gamma-tubulin staining of the spindle pole seen following RNAi-mediated knockdown of dgt2 in S2 cells.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Stably associates with the polar regions of some acentrosomal meiotic spindles in contrast to the uniform staining observed over mitotic spindles in syncytial embryos.
Sequence:
MDDPSATLLPEHSEDLRLARDAELKKVLKLKLVLDELRRLDVGPNPSDEIKRALKLVSIGSYARLGEMEGAGQEQVLGLPSGSSFPPLNYTDRKTVRTKLSAQLRTTLQPIAELCDRIREEFPDAFGQEADLSCDQKEILRLEEEHRSGLEKLVALLTRKCTLLKETAELKLGPQLANELKLQQAQAQLVQTKAELLRGFFVHEAASRTEHSVKAHKEVEAHLDELLAAKK
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Subcellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein. Note=75% cytoplasmic. 25% associated with the cell membrane.
Sequence:
MDYLKPAQKGRRRGLSINSLSETQQSAMNSSLDHLQNDLNRINLQWNRILSDNTNPLELALAFLDDTSVGLGHRYEEFNQLKSQIGSHLQDVVNEHSQVFNTNVASYGKAVSSIMQAQEQTLNLKNCLKEANEKITTDKGSLQELNDNNLKYTKMIDVLVNIEELLQIPEKIEENIRKENFHQVQILLERGFILMNNKSLKTVEILKPINQQLELQEHLLFNNLIEEIHDIMYSKSNKTNFTRVTNNDIFKIISISHNGFTSLENYLYNIVNIDIMEHSKTINKNLEQFIHDQSLNKGNIMLQENAATQAPLAPSRNQENEGFNRIGFLLKTINNINKLPVAFNIITERAKEEIHNIIVKSTESIRSKHPSLLKMATSLKNDNHFGLPVQDILSIILRECFWEIFLKLLYAIQCHRAIFEMSNILQPTSSAKPAFKFNKIWGKLLDEIELLLVRYINDPELISSNNGSIKPINGATNNAPTLPKRKNPKIFSLEYNIEDNSSVKDQAFELKALLKDIFPGFSVSSNMDLDSIYVKDESFEQDEPLVPPSVFNMKVILDPFLLFTQSTSTIVPSVLTQNTISSLTFFDDYMNKSFLPKIQMTMDYLFTVEVESNNPYALELSDENHNIFKTALDFQRLFYNLLNVFNTANTFREKISYCILDLLNHFYNYYLGLFNSLIGTSDRHLTRKIITAWLQNGILMDQEQKILNGDETLFHEESIELFKEIPHFYQAGKGLSKSDLFNNLTLDTILQFSASVLWILNWLPGLKKAINIDEVSQEPMLDADRLRSSWTFSESMDLNYSNPSSSPNSLGNLKILLDDKASKKFDETIDGFKTLKFKLITILRFNIRALCIYDIGSFFQNTKIWNMDVGSIELDQNIASLISELRRTESKLKQQLPEKEKNSIFIGLDIVNNYALIKGAKSIKVLNHNGIKKMLRNVNVLQHAYRNLSSEPSKINMNVTMNFYSLCGSSEAELFEYIKDNELPHCSVEDLKTILRLQFSEEMHRQLKRQSTSSTKGSIKPSNKRYTEALEKLSNLEKEQSKEGARTKIGKLKSKLNAVHTANEK
The following text describes a protein:
Function:
Tegument protein that plays different roles during the time course of infection (By similarity). Participates in both the accumulation of viral mRNAs and viral protein translation at late time of infection (By similarity). Modulates the RNase activity of the virion host shutoff protein UL41 probably to ensure necessary levels of key cellular mRNAs and proteins (By similarity). Plays a role in microtubule reorganization that occurs after viral infection by stabilizing microtubule network (By similarity). Plays a role in the inhibition of host innate immune system by targeting the CGAS enzymatic activity which is the principal cytosolic DNA sensor that detects invading viral DNA. Acts by mediating disruption of liquid-like droplets in which CGAS is activated, thereby preventing CGAS activity (By similarity).
Subcellular Localization:
Virion tegument. Host cytoplasm. Host nucleus. Host Golgi apparatus. Note=One of the most abundant tegument protein (about 2000 copies per virion). Localizes in the cytoplasm at 8 hours postinfection and in the nucleus at 16 hours postinfection. During virion morphogenesis, this protein probably accumulates at the trans-Golgi where secondary envelopment occurs.
Sequence:
MARFHRPSEDEDDYEYSDLWVRENSLYDYESGSDDHVYEELRAATSGPEPSGRRASVRACASAAAVQPAARGRDRAAAAGTTVAAPAAAPARRSSSRASSRPPRAAADPPVLRPATRGSSGGAGAVAVGPPRPRAPPGANAVASGRPLAFSAAPKTPKAPWCGPTHAYNRTIFCEAVALVAAEYARQAAASVWDSDPPKSNERLDRMLKSAAIRILVCEGSGLLAAANDILAARAQRPAARGSTSGGESRLRGERARP
The following text describes a protein:
Function:
Knockout of the gene for this protein causes small aggregate formation. May regulate the secretion or processing of a secreted factor that regulates aggregate size.
Subcellular Localization:
Cytoplasm.
Sequence:
MEEIKETVEKKNKEKKYLNDYKIISEGNNIKVLQKKDFKPKFSLVSYKNYEQNFDFENAKIVSTNFAIDRHIKMKNPPDPFVFIKMPSSKLVQSQLKLYYENEGYKDIPVWITPCSAFMRYIKSYPIVGTVTETMEKKKGFTNRFLSTSETKASVSVGFFGCESSMEVTSGYEYEDTVTSEETRSWSQTLNEGSYIVYQNVLVYAYIIYGGSYKPYIDQMNKFNPGLNIKFFREDKCIFFVPINRDDAFTLRYQDNTWDPVEYDVLIDYLGQNQDKWFSGGLP
The following text describes a protein:
Function:
Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure.
Subcellular Localization:
Nucleus.
Sequence:
MSRRKQRKPQQLISDREGPSAPESGDASEDDHPQVCAKCCAQFTDPAEFLAHQNACSTEPPVMVIIGGQENPSSSATSSEPRAEGRRSPQVMEAEHSTPPAPGGAAPADPSWAPERRVEEPAGHFLVAATGTGAGGGGGLILASPKLGATPLPPESAPAPPPPGHLNIPLILEELRVLQQRQIHQMQMTEQICRQVLLLGSLGQAAGTPASPSELPGTGPAASAKPLLPLFSPIKPVQSGKTLAPSSSSSSSSSSGAEAPKQAFFHLYHPLGAQPAFPTGGAGRSHKPAAAASAALSGSAEPLMASPHLAFPGATGLLAAQCLGAARGLEAAASPGLLKPKNGSGELGYGEVMGPLEKPGGRHKCRFCAKVFGSDSALQIHLRSHTGERPYKCNVCGNRFTTRGNLKVHFHRHREKYPHVQMNPHPVPEHLDYVLTSSGLPYGMSVPPEKAEEEVAAAAGGGERKPLAASSAALSATESLTLLSTGAGAAATPALPAFNKFVLMKAVEPKSKADENTPPGAEGSGTAGVAEGGPAARLQLSKLVTSLPSWALLTSHFKSAGGFPFPYVLEPLGASPSETSKLQQLVEKIDRQGAGAPSSATSGAPPASGPTASAAASGPNQCVICLRVLSCPRALRLHYGQHGGERPFKCKVCGRAFSTRGNLRAHFVGHKASPAARAQNSCPICQKKFTNAVSLQQHVRMHLGGQIPNGAAAPDQGAELPAVPGPGPQPPSQQPSPEEELSEDEDDDEDDDEDGTDEDSLAGRGSESGGEKAISVRGDSEEASGAEEDVGAAAAVAGQAGQAGPRPEGDEQGAQQPCLAAPPPPERPEETQPPEQGGAAAALGAQEQERGEAEAEAAAAREGPREGEGGGGDPGEELGAPEARRKEAGDGSGRKACELCAQTSLEEPQKAHPGEGPLFTCVFCRQSFLERAILKKHMLLAHHQVQPFAPHGPQNIAALSLVPGCSPSITSPGLSPFPRKDDPTIP
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
Subcellular Localization:
Nucleus.
Sequence:
MLEVRLTQQKLEMEDRESTCEATTSVSKGCFVFKSKKRRKPLYPGDYFIPESKSETSQDCKLRYETGDTQWELINDDIESLQADVNKTLFDDLLNFIKNAQAGFRLDQDLDTSRTRSRLKEIPTAAFVTGVNVTDHHDVFTKLASVFQERVSPHVVCLMSRDCTTLKGLMGSVVSQLMGIEYMASEDEDTMPEVNMKKVPCTFPVLQAWYKDNVQKRKLPGSTATFKSPRRSRKRRSMSGPVSYPECPPIIIVLEDFEGFKAVVIQDFIHICSQYLEKLPLVLTFGIATSVTVIHRLLPQSVSSCLSIEKFQAQPSSIYLSKVIDKVLLTAKHPLKLGSKVFQLLLDLFLYHDFSVMNFVQGLQVSILKGHIKVMNFVQGLQVSILKGHIKVMNFVQGLQVSILKGHIKVMNFVQRLQVSILKGHIKVMNFVQGLQVRILKGHIKVMNFVQGLQVSILKGHIKVMNFVQGLQYAVLDHYFSQPLSILCCRYGDAINRTRNLSHDQLELFRQASSFRRYVDGRPASDQRALLLDDKHMKKTLQELLKQMNEYHKAFFPVLECLHILSEGLPYHPLGKQMRELFAMATEGDIFATEAYQEAFKFMKMLARDELIKKMTMCEESLSRCEGLQEARFQLETLQAKMETLGDTCNQPVEIDSTEDDEEEVDTEGSKQNEHDTEETNLRGRREKTTLHSLQQMLMSNAKKKRRMTPYEILRNEILDFFDALFREYLPCPKNLPLHEVFYYNNVSEIRQRLNAPPRAAIQTALSNPNYYLQNPDCETLEEGITSSLPDVCIVYKLHLECGRLINIYDWLQAFMTVIQGESETDNADTAKKPDPVLQARFIRAVSELQFLGFIKPTRRKTDHVARLTWGGC
The following text describes a protein:
Function:
Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility.
Subcellular Localization:
Cell projection, cilium.
Sequence:
MGDEQLAKAGLFVDDFNRLRLIDPDVAELLQSAQDKSSEFNDQLKNFQTTTGGLIDSIEEFANVVETEKIRAMMVRNTQERDLAEDDPVLLQMTIRELTVEKERLRVELEAVRKIEKEQDECIQMMTEH
The following text describes a protein:
Function:
Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules. Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1 (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.
Domain:
Interaction between the cytoplasmic N-terminal and C-terminal domains (NTD and CTD, respectively) is essential for SLC12A3/NCC transporter activity. Phosphorylation by OXSR1/OSR1 and STK39/SPAK may activate SLC12A3/NCC by facilitating this interaction.
Sequence:
MAELPVTEMPGDALCSGRFTISTLLGGDEPPPAACDNSQPSHLTHGSTLYLRTFGYNTIDVVPAYEHYANSALPGEPRKVRPTLADLHSFLKQEGSHLHALAFDGRPGHELTDGLVEDETGANSEKSPGEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWLIILLSVMVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQENGTPIVDPINDIRIIGVVTVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPASKDKASKGFYSYHGDIFVQNLVPDWRGIDGSFFGMFSIFFPSATGILAGANISGDLKDPAVAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGDVNDTITPGPGLCEGLACGYGWNFTECSQQHSCRYGLINYYQTMSMVSAFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFRYYSKWAALFGAVISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVSTFTQNLSLMICGHVLIAPGKQRVPELRLIASGHTKWLNKRKIKAFYSDVIAEDLRSGVQILMQASGLGRMKPNILVVGFKKNWQSAHPATLEDYIGILHDAFDFNYGVCIMRMREGLNVSEALQTHTAPEALVQEEQTSTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLHRKKRWGKCKIRVFVGGQINRMDEERKAIISLLSKFRLGFHEVHVLPDINQKPQVEHTKRFEDMIAPFRLNDGFKDEATVAEMRRDYPWKISDEEINKNRIKSLRQVRLNEILLDYSRDAALIILTLPIGRKGKCPSSLYMAWLETLSQDLSPPVLLIRGNQENVLTFYCQ
The following text describes a protein:
Function:
Forms the sliding-clamp-loader together with the small subunit. Functions as an ATPase enzyme. The clamp loader holds the clamp in an open conformation and places it onto the DNA. 4 ATP molecules must bind to the sliding-clamp-loader before the latter can open the sliding clamp. ATP hydrolysis triggers the detachment of the sliding clamp from the sliding-clamp-loader, freeing the sliding clamp to track along DNA.
Sequence:
MITVNEKEHILEQKYRPSTIDECILPAFDKETFKSITSKGKIPHIILHSPSPGTGKTTVAKALCHDVNADMMFVNGSDCKIDFVRGPLTNFASAASFDGRQKVIVIDEFDRSGLAESQRHLRSFMEAYSSNCSIIITANNIDGIIKPLQSRCRVITFGQPTDEDKIEMMKQMIRRLTEICKHEGIAIADMKVVAALVKKNFPDFRKTIGELDSYSSKGVLDAGILSLVTNDRGAIDDVLESLKNKDVKQLRALAPKYAADYSWFVGKLAEEIYSRVTPQSIIRMYEIVGENNQYHGIAANTELHLAYLFIQLACEMQWK
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MAEAMRASVAELLHGIDRYNPENLATLERYVDLQCKENTYDLEANLAVLKLYVTLNKQTNKQTNCSTLPYIPTWLSSNCTLPKTNKQTNKRTVVRYLIYQPGCPQTVRYLKQTNKQTNELYPQTQEEEMITRVTFLADLLETCQFKNFWKEIALTPEVIEGVSGFEDSVRKFICHVVSITYQRIDKQTLLELLGDIDDQQLKQWMNKYGWRDDSEGFVFLANQEENVKTKNIVEKIDFESVAGIMAAAIQR
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MVRGKCMVCDSPNATNYHFGAQSCKACAAFFRRSIAMDQCYECLGDGVHSCKIDHTLRLNCRHCRLKKCQKAGMMRDLVQAKREIKSDKGKNSRNSSQSEDFFSPPPEQPGPSNYFDQFPWQASENEMDPYPSSPKIRKMSENLMGIDELQQFIQIPAGVDDFPDIFTDSDEIRSRMTSISEASAYVTGMEEEERLFGLAGLYTEQVINLNMRRRITYTDRLLGSVFDAPCVCPYDKADLKLFDHRTYRQKNRNDYTMILDYINRFPEFESLSKSEKTVLFRTAAAVDVLLDQSYYSQVIFPTEDVLVTANGEYLPMNPMPKVENQRDSGNFHSDEDYDRFKMLTSMKVRQWLHVCEPMKKLDMSLAEFSLFKALTIWHYNYYKLQCTGKQICSRQRDDIFRTLLLICDDEGHDSALIRASEIVLAVGIAMAEVHEMVTSYIEITVYDVLDDPILKDMLKFQY
The following text describes a protein:
Function:
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis.
Sequence:
MQSNIENVSRDYAKILQSADLEKEINPLCTNIEDMLARLDEFETLLASVRAESNGMMANNVCSILGFTDSFEQLKARIDGLEQCVGVVSANLSEVERSVDIAEEELHVTDYSLKGLLLKPLKAKLSASDTSTLSSLPRSNLVEEEYQPVEIYKSDDYFGKSEEENYVAK
The following text describes a protein:
Function:
The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein. The carboxylated form binds strongly to apatite and calcium.
Subcellular Localization:
Secreted.
Sequence:
KFPQPKWSLGKSKCECTNVCSSLCSSVVEPEVIVDLAADADTEVTPAAPAASSSESNSASSSESDSTSDSADSNSSSDSSASDSTSAASSESSSSESSESTSAASSQSSSAESSESSESSESDSSAASQSSESDSAASASSSSSSSSESASAEAASDSQVVMKRDLAAVLLRRRRAASGGTLTPLQMESLKEVCELNVACDEMADTEGIVAAYTAYYGQVPF
The following text describes a protein:
Function:
Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (By similarity). Negatively regulates cell proliferation (By similarity). Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway (By similarity). Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSALGAPAPYLHHPTDSHSGRVSFLGSQPSAEVTAVAQLLKDLDRSTFRKLLKLVVGALHGKDCREAVQHLGASANLSEERLAVLLAGTHTLLQQALRLPPASLKPDAFQDELQELGIPQDMIGDLASLAFGSQRPLLDSVAQQQGSSLPRVSNFRWRVDVAISTSAQSRSLQPSVLMQLKLTDGSAHRFEVPIAKFQELRYSVALVLKEMAELERKCERKLQD
The following text describes a protein:
Function:
Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MKLQSTLYNVGYPVYGARFLNANTLLVTGGGGEGNHGIPNKLTALQINFSKKKIVKRFRELTLDENDDSPTTLDVAQDVILMGCNENSEKIRQGAPNHHLRKFVYENEHLKFVGAIDLNRSDNPEDYTKLLYMSQDGWVAAVASSAVPTVIRIVNPGNLRETYEVETGNDVKDLHFSSDGKVLAYITASTLEVISIVTGNFIVRKTDFDKNLSLSKIRFIGEDTLLIAAALKKGTGIVLTKLSLKKGNTQILRTCVITKKFKSVTSMDVDPKGQLAVLAGSDNSLALVKLRNFSVAKFFKQVHTFAVTRVVFSPDSRLLVSVSAANTVHVVQLPEDFATRTTLTENLIKFFTNFVLVVLVALFARFAHQHGLHTKAYNIVSNTLRKPENRRTSFFSDILNQQITLSGDVVSSSTTAVDTVHSSVDTSGWYLDSTRSGTDAVASGDRLDGGAATIESLAKSAGVDSPVEVETLPHANSTTFSEVTAYTGEYPEVVSSATSEVAMESSVDSKFMAIEASTTPAITISTSLQSMSVSDVYTGTSAAEDASSTGSDASVVLEKTAILNPSSTNIAEDEFVDAIAEPPSASVDSTPYVTAARDYSSEDTGERSEPTITEYKTAIESPSTFGDDNESVFLVTSADLHPSVSSASQTLTTEELQAVANSHQYKTEVQIVKQDEDEVEDVLELDSPPASLYDGDVLKEAEKNDSSNVIPDDSIDIDEYLDENLVKNFTLENALSLDEIFDDDNVVFGEEKLLVDPDLEFPELTGMEQDMESDYLPLIENGTEAVLQLDPNIDDIDLDNNMVYADDAQPVSDGLQNIAIMPDVIDNLEIQTFSEQEKQQLEPSSIESVATSLEVPNEATTYEVEAADLTSSVDPIEIVIETAETAYNDASPDIVNLENTLTSTEQQDSAPDINEVDDLETEVEVKTEFLEDIVDFQHPVETSAQFNVPKTPALEVIDQPQPVTQVQTVIETVVDGTTRPANALLMNSTVEVITVKEIVKETVFVTEKVTN
The following text describes a protein:
Function:
May play a role in ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MGIKERNAPSQYKQSSRKNKRAWRKNIDLEDIESGLEQTRDEEIKGGNVEHKPNDALFVIDTLGDDRIAKRSRKKIKPLKVDQILENKSSIEKVHSHLTNNSTESNKKGKIFSRKELNRLQALVYKNKDGLTATSAASELKNTKQPKESYDVWETNPTVTIPVKRPSTLSKLPESLTENNAKVPNVVIADPGMSYNPDAAAWMKLLDTKGSEELKKEQKRISELEEKERIQKKAFEDKGLVSDQDVNHSIDSDDQSEHEQAETPIPSSKNKRKTRSQRNKIRQRREEELRLLEQKKNEELLRTIDKAPAISKKLQQKDKAEKFSNKAVSSSTTEIKLKKKKFGKHRLPNNPLEIKLGDELTSSLRELKPEGNLFADRYLSLQQRAMVPPSLPVLKKSKYRAKIKEKYSHKDFHLQKNSI
The following text describes a protein:
Function:
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSSATPSPVPSSAHGHHKRHSILPAVSQSGPKPPVQFSSSCTIADSALLTGPHTIIVSTESVIHPRARLESLGGRVTVGRRCIVHERACLGAADLQGRYHKGSPDKEGRSMGAVTLGDYVTVEVGAQVESGGTVIGEGTTVGIGTRVGAGAVVGKHCTLTANSTVAAGEVIPDYTVIYSNGLRRIDRRGVSELKNKAQARQIDVLRRMIPSNPGKFQ
The following text describes a protein:
Function:
Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs). Required during vasculogenesis.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MCGSALAFFTAAFVCLQNDRRGPASFLWAAWVLSLVLGLGQGEDNICASSNAASCARCLALGPECGWCVQEDFISGGSRSERCDIVSNLISKGCSVDSIEYPSVHVIIPTENEINTQVTPGEVSIQLRPGAEANFMLKIHPLKKYPVDLYYLVDVSASMHNNIEKLNSVGNDLSRKMAFFSRDFRLGFGSYVDKTVSPYISIHPERIHNQCSDYNLDCMPPHGYIHVLSLTENITEFEKAVHRQKISGNIDTPEGGFDAMLQAAVCESHIGWRKEAKRLLLVMTDQTSHLALDSKLAGIVVPNDGNCHLKNNVYVKSTTMEHPSLGQLSEKLIDNNINVIFAVQGKQFHWYKDLLPLLPGTIAGEIESKAANLNNLVVEAYQKLISEVKVHVENQVQGVYFNITAICPDGSRKPGMEGCRNVTSNHEVLFNVTVTMKKCDVTGGKNYAIIKPIGFNETAKIHIHRNCSCQCEDNRGPKGKCVDETFLDSKCFQCDENKCHFDEDQFSSESCKSHKDQPVCSGRGVCVCGKCSCHKIKLGKVYGKYCEKDDFSCPYHHGNLCAGHGECEAGRCQCFSGWEGDRCQCPSAAAQHCVNSKGQVCSGRGTCVCGRCECTDPRSIGRFCEHCPTCHTACKENWNCVQCLHPHNLSQAILDQCKTSCALMEQQHYVDQTSECFSSPSYLRIFFIIFIVTFLIGLLKVLIIRQVILQWNSNKIKSSSDYRVSASKKDKLILQSVCTRAVTYRREKPEEIKMDISKLNAHETFRCNF
The following text describes a protein:
Function:
May be required for sperm ADAM3 processing and consequential sperm fertilizing ability. In vitro, has an endopeptidase activity (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MPISKDKLILILGMVCLEQGHSETLSSIRNPDCGQSLVKPQPQNYFSLFSRIVGGSQVEKGSYPWQVSLKQKQKHICGGTIISSQWVITAAHCMANRNIALTLNVTAGEHDLSQAEPGEQTLAIETIIIHPQFSTRKPMIYDIALLKMAGTFQFGQFVRPVCLPEPGEHFNAGFICTTAGWGRLSEGGRLPQVLQQVNLPILTQEECEAVLLTLKNPITGKTFLCTGSPDGGRDACQGDSGGSLMCQNRKGAWTLAGVTSWGLGCGRSWRNNARKKEQGSPGIFTDLRRVLPWILKHIQTGHRRKSTKALCSEPDGLISGSEGELHFPESLHLYYESKQLCVWTFLVPEDMHMLLNLSHLDIESCHHNYLAMYSLEDRLVGKFCGENLPSSILIGSSSIRLRFISDATDYATGFNLTYKALKPRYHPDSGCRSLTILFEEGTIQSLHYPEDYSNMASCTWIFQAPNYCLIKLSFQSLEIEENGDCSSDYVTVHSDVEKEKEIARFCDYVIPSPVLSSSSVMLISFQSDENGTARGFQADISFISRADLNISISEDESVPLETWDLPPGAMEIFDAERDTHTKPPYEEDIGEMPAIDSGLLKQGERRGKH
The following text describes a protein:
Function:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Subcellular Localization:
Secreted.
Domain:
The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
Sequence:
MAALMRSKDSSCCLLLLAAVLMVESSQIGSSRAKLNSIKSSLGGETPGQAANRSAGMYQGLAFGGSKKGKNLGQAYPCSSDKECEVGRYCHSPHQGSSACMVCRRKKKRCHRDGMCCPSTRCNNGICIPVTESILTPHIPALDGTRHRDRNHGHYSNHDLGWQNLGRPHTKMSHIKGHEGDPCLRSSDCIEGFCCARHFWTKICKPVLHQGEVCTKQRKKGSHGLEIFQRCDCAKGLSCKVWKDATYSSKARLHVCQKI
The following text describes a protein:
Function:
Protein-L-histidine N-tele-methyltransferase that specifically monomethylates RPL3, thereby regulating translation elongation. Histidine methylation of RPL3 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Nucleus, nucleolus.
Sequence:
MTFQFNFTIEDHLENELTPIRDGALTLDSSKELSVSESQKGEERDRKCSAEQFDLPQDHLWEHKSMENAAPSQDTDSPLSAASSSRNLEPHGKQPSLRAAKEHAMPKDLKKMLENKVIETLPGFQHVKLSVVKTILLKENFPGENIVSKSFSSHSDLITGVYEGGLKIWECTFDLLAYFTKAKVKFAGKKVLDLGCGSGLLGITAFKGGSKEIHFQDYNSMVIDEVTLPNVVANSTLEDEENDVNEPDVKRCRKPKVTQLYKCRFFSGEWSEFCKLVLSSEKLFVKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVLLASKAHYFGVGGGVHLFQKFVEERDVFKTRILKIIDEGLKRFIIEITFKFPG
The following text describes a protein:
Function:
Involved in the biosynthesis of alanine. Catalyzes the transamination of pyruvate by glutamate, leading to the formation of L-alanine and 2-oxoglutarate. Is also able to catalyze the reverse reaction.
Subcellular Localization:
Cytoplasm.
Sequence:
MSPIEKSSKLENVCYDIRGPVLKEAKRLEEEGNKVLKLNIGNPAPFGFDAPDEILVDVIRNLPTAQGYCDSKGLYSARKAIMQHYQARGMRDVTVEDIYIGNGVSELIVQAMQALLNSGDEMLVPAPDYPLWTAAVSLSSGKAVHYLCDESSDWFPDLDDIRAKITPRTRGIVIINPNNPTGAVYSKELLMEIVEIARQHNLIIFADEIYDKILYDDAEHHSIAPLAPDLLTITFNGLSKTYRVAGFRQGWMVLNGPKKHAKGYIEGLEMLASMRLCANVPAQHAIQTALGGYQSISEFITPGGRLYEQRNRAWELINDIPGVSCVKPRGALYMFPKIDAKRFNIHDDQKMVLDFLLQEKVLLVQGTAFNWPWPDHFRIVTLPRVDDIELSLSKFARFLSGYHQL
The following text describes a protein:
Function:
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.
Sequence:
MASVEPIKTFEIRQKGPVETKAERKSIRDLNEEELDKLIEAWRWIQDPARTGEDSFFYLAGLHGEPFRGAGYNNSHWWGGYCHHGNILFPTWHRAYLMAVEKALRKACPDVSLPYWDESDDETAKKGIPLIFTQKEYKGKPNPLYSYTFSERIVDRLAKFPDADYSKPQGYKTCRYPYSGLCGQDDIAIAQQHNNFLDANFNQEQITGLLNSNVTSWLNLGQFTDIEGKQVKADTRWKIRQCLLTEEYTVFSNTTSAQRWNDEQFHPLESGGKETEAKATSLAVPLESPHNDMHLAIGGVQIPGFNVDQYAGANGDMGENDTASFDPIFYFHHCFIDYLFWTWQTMHKKTDASQITILPEYPGTNSVDSQGPTPGISGNTWLTLDTPLDPFRENGDKVTSNKLLTLKDLPYTYKAPTSGTGSVFNDVPRLNYPLSPPILRVSGINRASIAGSFALAISQTDHTGKAQVKGIESVLSRWHVQGCANCQTHLSTTAFVPLFELNEDDAKRKHANNELAVHLHTRGNPGGQRVRNVTVGTMR
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSSSIGPRVGQGTAAGQAVEGIARKLEAEGKILGTLLLSLAFMEALKIYGLVVALALLFANPFV
The following text describes a protein:
Function:
May be involved in agglutination during conjugation or other aspects of colony formation (By similarity). Induces flocculation when overexpressed.
Subcellular Localization:
Cell surface.
Sequence:
MNVVKYIIFSFALAPLLLVNANTYNFTQIQKRSVNQAVLESSQDTNSVGGEASSTACPLFTTIYTNGITPGTTTIYPTSISTSGVSSNNIDETSVSSESIITSTITTTITSGSQLYTTTITGQNTPVDTVEVVIPTAGTFTTTLTSGSSYPVATTTVRTASGTQSGEVEVITPSCGCSPENSFHLKIDNDKISPSYVYMDPNAPVRTNGAGREGNMFASTNGDNEGLNLFYYDSTIQRVLTCDCQRPSYTVYIEDPIIGNGFSSAWNLIKNSDGIFTPVESRNNEPLHFHVDNNGRVWMTSQEYDTEVSSTDERNFRANDVTLQLY
The following text describes a protein:
Function:
Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
Sequence:
NPVPSALSELMTSGWTSGEELGTDGETGAPPKWEKMIKMLVHEVTTLRNQQFVEEFQKPVEEISSFSQHQVPSTPPHLSKTLCSTSNKEACLQEISRGLQVYQLLLQHVKAEYPQSTLLPSVTHQTTVLIGLVKDQMKVAEVVEDLSASERKRVLGEVSTGTEWERKTSVHAILRELRNFLVDTKRALRRMGKRGKDFQ