lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
Subcellular Localization:
Nucleus.
Sequence:
MCLFDRKPAAISGTSISIGKPKNTMDCNLHIETDYDKETPHCEHKNHSEPEYGTQESNYEEESNGEEIAEEEDPDGEAKPCEREVIEGLYWTEPTEEDPQEQVPDEESIGVHDQEDVSEGFRSQSSSNGDDEECELGSKPSSSDKKRRSADESQGNMQKRQKQDDSKLEIYSYATGVIFKDKARSSSCDENIADKENTGSSGKRKRSRSNMEPETYKVEVDIDLATKKRKTRSVNNDAKLKLLGPLKLPDFDKIPVGGTSVDPVTEKLNSQLFEVNRMLSAHVLVDDQPKVNESDIQMNSRVARLRTRLIKHRQKIILELIKRNPTFDPPDIKPPKLSKKLYIPVKEYPSYNFIGLIIGPRGNTQKRMEMETGAKISLRGKGSIRKGRVLTYKDSRCESSEDDDLHVYIKADTQNSLDSAVQMVEKLLVPVEEEMNEHKRAQLRELAVLNGKLGKDSSEVQKTTPRSSTSCDICGIAFHQSVACPLIASNTGIGKSDKFFVQLGSSGVGPFNYPPLASTISSLMSNQQFHAPASSNSIPLKEIDEAKLYVCYLPLSVNDDKLLELFSPFGCISEAIVIRDKTTGLSKGYGFVKYRDPAFAAEAAASMNGCRIEGKMLSVQVANQPSSASKTCTFPWLLNNCNKLPPYPTTAISQGKPGVMTWPGHPGSMISETRASIPKKSSFISHAGFIRGPPFFFGASNQNSVPSLIPDAVTSFKEPEQFPGYPNNIEFQDQSYCSRYHYRLPSKYVHPTQTHDSYRASFAHQMPPP
The following text describes a protein:
Function:
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MTRIKRGYIARRRRTKIRLFASSFRGAHSRLTRTITQQKIRALVSAHRDRDRKKRDFRRLWITRINAVIRERGVSYSYSRLIHDLYKRQLLLNRKILAQIAISNRNCLYMISNEIIKEVDWKESTRII
The following text describes a protein:
Function:
Acts on leucine, isoleucine and valine.
Sequence:
MNGEFVEKEKAVVSVYDHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPMTVEEMEEAVLHTLQKNEYTDAYIRLIVSRGKGDLGLDPRSCVKPSVIIIAEQLKLFPQEFYDNGLSVVSVASRRNTPDALDPRIKSMNYLNNVLVKIEAAQAGVLEALMLNQQGYVCEGSGDNVFVVKDGKVLTPPSYLGALEGITRNSVIELCERLSIPCEERPFTRHDVYVADEVFLTGTAAELIPVVKVDSREIGDGKPGSVTKQLTEEFKKLTRERGVRVPRLTESLA
The following text describes a protein:
Function:
Cell wall formation. May play a specialized role in remodeling the cell wall. Specifically hydrolyzes the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi (By similarity).
Subcellular Localization:
Periplasm.
Sequence:
MFKKALFILSLCPSFALAQSYVVYDFTHNRVLESHASDSIQPIASVTKLMTANVFLENNKNPNCRIAITKEDTDRIKGTGTKLPKNIPISCNELLKAMLVHSDNYAAHALSRAAGISRRQFIKKMNEKAHQLGMYSTRFHDSSGLSSYNISSPMDLVKLAKYSLNKSDIKRLSNLSATYIQAGKQKLYIKNTNKLVRDEIFDAAVNKTGYIQESGYNLVFINKHRCKNATIGVISLNNTSSAYRSSFTKSKLEKFGCTALNGRTIRDVAGEAQYEDGYDEVGFNTLIQKLSK
The following text describes a protein:
Function:
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Subcellular Localization:
Nucleus.
Sequence:
MPKARASKSAKANKPNKDVNQWIMLAPDDALSSTPESESPPLFAKIPHPRTGKGVQLLFSSDEKSVCEVAKFKDEPRSWFIDDTVHEDGSMVIATPIDSVFLCLPYLEKCSSQFRTLDQILIDSKFPSVGKLTNCITHESLTSVCDCKGDDDLHVYRINEDKTMAWLKTKVECVADYLATSDINVSKGSQSATFVRSRKHSDVTREDHLRYSSGMICDYLSLSWEEKLKKALNLPEKDKEKEVSDEEPPSKRVKLEEGSETVEDYSKEYEKLKSKIPAGKTPGKMTAGQRALSKVDKTGMKSISSFFGGGKKTSKK
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Sequence:
MLLGVFFFHSETVDLCLSPGLCGYTAVTRVAGATARGRTVLAARVYFRNCFRLRPSSFPHRRDATMVNVPKTRRTFCKKCKKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKGQVIQF
The following text describes a protein:
Function:
Possesses 5'->3' exoribonuclease activity. Acts as an endogenous post-transcriptional gene silencing (PTGS) suppressor.
Sequence:
MGVPSFYRWLVNKYPKVVQDVVDPTMQEDPNGVKFGNLYLDMNAIIHPCFHPEDDDNIPFPTTFQDVFRNVFDYIDRLVETVRPSKLLYMAIDGVAPRAKMNQQRSRRFRAAKDNEIQEAEEERLRRQFGMKRKQVLPKQQSDVSDSNIITPGTEFMHELSKALKSYISSRITSNSLWKDIMVILSDANVSGEGEHKIMSYIRKQLSLEGYNPNTSLIWLTFEFEMQDVDLIMLAMATHEPHFSILREKDPHKNYSIEFERIIDDFIFICFFAGNDFLPHMPTLEICEGAIDLLMTVYKKEFNKLGGYLVDMSMSRIGEKNAAFLKLSRLEKFMLAVGAYEEKIFKKRSEIREKYLRRFIRDSEDAKQDEENATCYSDLDEENTSDCTLLIKSVLVNNVSATHAEYQIEQNTKDLKDELKICIREKCDLFQSGNFLTDKIKLGTTGYKERYYKAKFSVEGPTDIECKRKEIVQKYTEGLVWVLQYYFSSVASWTWFYPFHYGPFASDLKGMGQVRVKFEKGVPFLPRDQLLSENEAIRNSVKADSLFVRSASELAEKFGSLSLDTNPPCKLETISSDGIGGNISLCDEFIEKPCLDICDNKKEDRVLCVYYELPAGSNHIPRLLSDVKLPEKTIFEIDIMETELWHEPQKYYSRFERVQNQDKWRSENTSNTSRFPPNASNQHARSFVYKDAGVGLGSGRGKRIDAMANESVPNNIRTQHFVDNFRQLRISESNNHFPRPGGGSSQSRPHNIGHINQSRNAPYHQGSQYNNGYMNQPRNAPYHQGSQYNNGYMNQSKNAPNHQGSNYLTVSNVGPGQGRGASSNSSLRPQWSGGNSYQVKDQNLW
The following text describes a protein:
Function:
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit (By similarity). Required for embryo development.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRAKHIGKNYSSSLSPVLSPEHKPSLLESQAIGTVATAQANFMRVIVQDVANSVTSDDDNDSSKTGVELLCVVRAVLKKIRRRVLVGDKVLVGSIDWVDRRGMIENVFHRRSEILDPPVANVDHLLVLFSLDQPKLEPFTLTRFLVEAESTRIPLTLALNKTELISEEELETWKIRLRGWNYEPLFCSVGTKDGLDDIAFVLRDQTSVIVGPSGVGKSSLINVLRSNHGGGVVEDENWFEPMLGNKWFDDQRVGEVSSRSGRGKHTTRNVSLLPVSEGGYLADTPGFNQPSLLKVTKHSLAHCFPEIRNMIESEKCGFRDCLHIGEPGCVVKGDWERYPYYLQLLDEIRIREEFQLRTFGTKREDDVRYKVGDMGVKHAEPRLMPKKHRRESRKKTKQTMISELDEFEDEDSDLYIENDPIVQAIENENKRQ
The following text describes a protein:
Function:
Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.
Sequence:
MGSLTSVDKSRIRQAFQKALNDYDRHALIQQKMTINLMAHLQDYLPNGSLDSVLELGCGSGMLSSLLQKQISADYWLFNDLCDVQTQLAEKLPQSFDFYCGDAEHFLFLQQFDLIASASAVQWFHQPDAFIAHCKTGLKTNGLLAVATFGEDNLKEVRQITNIGLNYPTLSQWQTWLAKDFELLWCEDFKVILDFDTPLDVLKHLKYTGVTATNQKNWTRKNLNGFIGDYLSAFGMPSGKVRLTYHPLFFIARYSHIENQ
The following text describes a protein:
Function:
Catalyzes the ultimate step of the pyrrolysine biosynthesis pathway by converting the isopeptide (3R)-3-methyl-D-ornithyl-N(6)-L-lysine to the 22nd proteinogenic amino acid.
Sequence:
MALLTPEDLENINRQLHEADSTVRRVTGLDIKGVCKDFYGTTPCCEKVGIVPVTSGNGIIGNFSESLRAITEYFGFDSFVTTMPDVSGYYEAVRNGAQIILMADDNTFLAHNLKNGKIANNQPCTGIIYAEIASRYMKADSKDVLAVGLGKVGFPGAAHLVNKGFRVYGYDADKALLEKTVSDLGITPFEPENPRRFSIIFEATPCADTVPESVISDNCVISTPGIPCAISRELQEKYGVELIMEPLGIGTASMLYSIL
The following text describes a protein:
Function:
Selectively catalyzes the oxidative deamination of acidic amino acids. Suppresses the level of D-aspartate in the brain, an amino acid that can act as an agonist for glutamate receptors (By similarity). Protects the organism from the toxicity of D-amino acids (By similarity). May also function in the intestine (By similarity).
Miscellaneous:
MISCELLANEOUS: The enzyme is inactive in complex with 6-hydroxy-flavin adenine dinucleotide (6-OH-FAD); the complex is not physiologically relevant but an artifact of purification procedures.
Subcellular Localization:
Peroxisome matrix.
Sequence:
MVKIAVIGAGVVGLSTALQVKQNFPFCSVTVVAEKFNTETTSDGAGGLFRPNFLTLSANPLESIKQWSQDTFSHFNNLFNSPEASDCGIALMSGFLLSNKEKLDMIEDISLGQSKMTAEQIAKMGFDCKHVTKVLTYTMECRRYMPWLTSKFLSLGGSMHHHRLKSLEELVGVYDVVVNCSGLGAKDLVPDPLVYPVKGQLIQVEAPWVKHFYFFEDDTYVIPNINRTSLGGIRIKNDYSTEVDPEISKSIWQRCTSRIPSLQKAKVLWEWAGLRPHRDPIRIEQDVMNFPKGTLKVVHNYGHGANGVSLSWGTAKHATRLVRQFLENDPELRSKL
The following text describes a protein:
Function:
Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation.
Subcellular Localization:
Cell projection, cilium.
Sequence:
MIDAALSSSGAQVVLATSSDENYPPENIIDGSTETFWISTGMFPQEFIIRFSGTQKIRLVTIQSYNVKNLKIQKSTFSDATDFEGIIDKEFEHTEGQLQSNDFALNGTRATHLRFIITSGFDHFVSVHRVMVEGSSESNL
The following text describes a protein:
Function:
Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It prefers the antibiotic chloramphenicol.
Sequence:
MPTPGTGSVPELQLVPFQLGHFPILQRWFATEKELVQWAGPALRHPLSLEQMHEDLAESRRRPPLRLLWSACRDDQVIGHCQLLFDRRNGVVRLARIVLAPSARGQGLGLPMLEALLAEAFADADIERVELNVYDWNAAARHLYRRAGFREEGLRRSATRVGRERWNVVLMGLLRQEWAAGGAGND
The following text describes a protein:
Function:
This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity); The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
Sequence:
MIAFAKQYRVHISPQKARLVCQLIVGKKINDAQNILLNTPKKAAYFLTKLLNSAISNATNNHGMSGDLLYVFECVANQGPSMKRTIARAKGSGSVLTKRSSNLVIKLSDNPNERKLLLTQQKELVKKRTMGHKKEKAKQKQKQQ
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Sequence:
MPGQSKTAAIAPPASEIAILGAGAVGQLICHQLHSAGLAVGLIARESFASNIEATHWQDLVFSPLLLNNTNTESVSYRVPKLDIESKSAQQIKLLIVCVKAYQVLDAISPLLDKLSPQCHILLLHNGMGPHLTLAPRLNGRGLSLGTTSQGVLRQSCWQVKQTGQGLTQFGHFTGPELPQALRERLLHAIPNSEWVEAIIPSLWQKLAVNAAINPLTALHQCPNGTLAQAQFSKTIATILDELVEVAAHDGVELDRQRLEERVYRVIELTAANFSSMHQDVAHHRPTEIDQINGYIGDRANAHGLSAATNAQMVQSIKQLSAIPPVQ
The following text describes a protein:
Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Miscellaneous:
MISCELLANEOUS: Has a low cysteine content when compared to the majority of known KAP family members. Possesses several C-terminal tyrosine-containing tandem decameric repeat structures.
Sequence:
MPAGSMSTTGYPGVCSTTSYRTHCYIPVTSSVTLSSSDLSPTFGHCLPSSYQGNLWLLDYCQESYGEAPTCKSPSCEPKTCSTTGCDPSNSSVPCNSPSAGQVFSVCETTNVSPSPSCSPSTQTNGYVCNCHIPTRNASKACQTLRNGSNCFGQLNCLSKSFQTLNHCRLSTLGYKSYQNPCFIPSYVSPLCYISNSCQPQSYLVRNYHYSSYRPTSCRPLSYLSRSFRSLSYIPSTFPPLRYLCSGSRPLKCY
The following text describes a protein:
Function:
Required for the activation of the NF-kappa-B factor Relish (Rel) by acting as an essential signaling component in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation, which is required for direct activation of Rel. Phosphorylates inhibitors of NF-kappa-B (cact) thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the NF-kappa-B inhibitor. Essential for antibacterial immune response. Also required for antiviral immune response.
Subcellular Localization:
Cytoplasm.
Sequence:
MITVVFCFSDCHGGIQILGRMSSVNKIKLNENNKMHSFGNWERCRNLGEGGFGLVIHWRNRTTGREIATKHIKEMGALSADQQVKLSERWNKELNWSRQFKNFPHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRKRLQSPENANGLTEFEVRQILGALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSVVGTRHYYAPEVVENGFYNSTVDLWSFGVIAYELVTGELPFIPHQTLKNIILNLIKKPAKCIAITEDPEDNTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSNYKERGQLAANNVPVVFADLDKILNMNVLTIFAVNNCERLEYAVSAEMTMKDLIALIVLDTGMDEKELYFVLPTSHPHKTITPKSTPLQLYVEEWSDTSKDSRKWTKRSNPPVMLYIFQVKKECDYKIPEPILSILSRKFIANKFKTKERWLQKRVVLDMLYVLTKEQARYEMLVSGINERALSLEDEMMENSFIDSIDKQRIIISFAYDQLTSLLKEAQAKIPSRQLISSAQWEKLNRNYNFIIQSAKSIRSFLEACLREAKDMVKTTNQLRKEVCEKDLFDCARFYKKYLCNGAIISPSELNNDAEEFAKSRFKLYNEGEARHLPKSIDHMHYLYFKTKESIPVLLQQFCDIKKEIFQINLQMLMSASSTPPPKLELSAAMDRLAISSGSPSSDPFDSLRTINAIEEAERINNILVNEMKIDHY
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MAGEDSSDSIIVNVDGDDNKSALFGKYDLGKLLGSGAFAKVYQAEDLHNDRESVAIKVVQKKRLKDGLTAHVKREISVMRRLRHPHIVLLSEVLATKTKIYFVMELAKGGELFSRVSSNRFTEKLSRKYFRQLISAVRYCHARGVYHSDLKPENLLLDENRDLKVSDFGLSAMKEQIKSDGMLHTLCGTPAYVAPELLTKKGYDGSKADIWSCGVVLFLLNAGYLPFRDSNISGLYRRIRTAQYTMPEWTSPELTNLLRRLLEPIPEKRITVDEILKDPWFNHGVDPSEIVGIQVDDYDLEESGKKLNAFELIASSSTANLAGLFGNFVTPDHCDQFVSDESPAEIMRKVVEVARQLNLRIAKKKERAVKLEGSQGVTNIVVKIRRLTDELVMVEMKNKQRDVGLAWADELRRKLRRIINQPVNRGP
The following text describes a protein:
Function:
Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.
Miscellaneous:
MISCELLANEOUS: Present with 1240 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MSFWKTLQRQPRTISLFTNDIASNIKSQKCLQLLKGDVSHRFDVEIANRFPTWDQLQYMRTSCPQGPVSLQRQIPKLDSVLKYKHTDPTFGMDLQKCVQRGLWNPKEALWVDWENKLVGNEPADIDKYIIQRK
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MLFYLFTGGDNRRVYLGTRSVRSGWIWRRIAGWGVHLAARTHSPIRVRQSEARCDRAAPRASMRLCEGLYFLILWVQLSHPLHLVSASRLPFSPPTDCRAETLNQISHRAVGSPLVMDHRSICRKTRRLIGKQAEICRKEPEIVHEVIKGAKLGTGECQFQFKERRWNCSTADKFFGRILNQDRGRGNDWWRNLQDIRETAFVYAVTSAGVTFAVTQSCSMGELLQCGCDYQMKGESPDGSWEWGGCGDDIDFGYTKSREFMDAQTRHRSDIRTLLTLHNNEAGRLAVKNFMRTECKCHGLSGSCAVKTCWKKMPIFREVGVRLKERFNGAFQVMGSNNGKYLIPVGDTIKAPTAEDLVYTNESPNFCKRNRKTGSQGTKGRACNATSMGIGGCDLLCCGRGYKERQVVVEENCKCRFHWCCVVKCSKCTAVKTVHECL
The following text describes a protein:
Function:
Negative cell-cycle regulator that functions at the G1-to-S-phase transition. Required for suspension of the cell cycle in dauer larvae and starved L1 larvae. In vulval precursor cells (VPCs), a pathway of heterochronic genes acts via cki-1 to maintain VPCs in G1 during the L2 larval stage. Cul-2 may function in ubiquitin-mediated degradation by targeting cki-1 for degradation. Involved in distal tip cell development by repressing and modulating cye-1/cdk-2 activity levels in Z1.aa/Z4.pp and in Z1.ap/Z4.pa.
Subcellular Localization:
Nucleus.
Sequence:
MSSARRCLFGRPTPEQRSRTRIWLEDAVKRMRQEESQKWGFDFELETPLPSSAGFVYEVIPENCVPEFYRTKVLTVRTTCSSLDISSTTLTPLSSPSTSDKEEPSLMDPNSSFEDEEEPKKWQFREPPTPRKTPTKRQQKMTDFMAVSRKKNSLSPNKLSPVNVIFTPKSRRPTIRTRSSCSPY
The following text describes a protein:
Function:
Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.
Subcellular Localization:
Cytoplasm.
Sequence:
MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTPIKADISGNITKIKAVYDTNPAKFRTLQNILEVEKEIGLRFIQVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIFQAALYAAPYKSDFLKALSKGQNVTEEECLEKIRLFLVNYTATIDVIYEMYTQMNAELNYKV
The following text describes a protein:
Function:
Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor. Note=Localizes to cis and medial Golgi cisternae. Probably cycles between early Golgi and distal compartments like endosome (By similarity).
Sequence:
MGNGMCSRKQKRIFQTLLLLTVVFGFLYGAMLYLELQTQLRKAEAVALKYQQHQDSLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELRKQHSDLEEEHRKQGEDFSRTFNDHKQRYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKTQVAEYKQLKDTLNRIPSFRNPDPVEQQNVTFPHGTHPPQGYNGREKLTGELQEVQPNHEAGPRRMEEKPLSSMQKDAGFQALEEQNQVEPREPEERQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDRDWRDQQGQNAAHLLDGHPQAEVEHSTKAATNFQSPYEEQLEQQRLAARRDEEAQRLREHQEALHQQRLHGQLLRQQQQQQFLAREMAQQKQVAHEDGQQQHQEQLRQQAHYNAVENDIAQGVEDQGIPEEEGGAYDRDNQRQDEAEGDPGNRQELREPGHQEGDPEVEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPEESEEQKQSEAKQGNVEMDEHLVMAGNPDQQEDNVDEQYQDEGEEEVQEDLTEEKKREMEHNVEETYGEHPDDKNNDGEEQGVHNRAHPKGRQEHYEEEEDEEDGAAVAEKSHRRAEM
The following text describes a protein:
Function:
Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.
Subcellular Localization:
Cytoplasm, cytosol. Endoplasmic reticulum. Golgi apparatus. Mitochondrion.
Sequence:
MDGITDEHEQGINLSELPKLRLVLIGVTESGKSAVGNAILGKKAFDEVGVKTRVCFARQGLVRGRQVQVVDTPGWEWFKVNGSSTSLWFVKKEMMMSMSLCQPGAHALLLVVPLSFSFSQRERHAVEEHIELFGQEAWRHSLVLFTILDRKQLRGSSLKQEVELNVELYKLVEKCGGRFHALYSNPKAGEDQVADLLAKITKMMETNGETMISSKNVLEKVKEMEKEEERKLEEERKLKEENLQKVREALKAKELRRSRRRMEQQTLDGVEQKGWAGDNQSNKIPLDEGGSNSLLSCKQQ
The following text describes a protein:
Function:
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consists of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B, activin E and NODAL. Upon NODAL binding, activation results in increased apoptosis and reduced proliferation through suppression of AKT signaling and the activation of Smad2-dependent signaling pathway in pancreatic beta-cells, trophoblasts, epithelial or neuronal cells. Acts as a positive regulator for macrophage activation partially through down-regulation of PPARG expression.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MPWAGLLHLGASLILLSAASLCTALKCVCLLCENTNYTCQTEGACWTSVMLTHGKEEVLKSCISLPEFKAQVFCHSSNNITRTECCLSDFCNNITLRLPAVTPRVYHMGHVELTVIITVSICLLSIVIMVTAYVCQGRYCTKKKARRQCVEEPLTECPMDIAGKSLKDLIYDMTTSGSGSGLPLLVQRTIARTVVIQELVGKGRFGEVWRGKWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLISEFHEQGSLFDYLNRNTVTIGGMMKLALSIVSGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNDTCCIADLGLAVKHDSITNSIDIPQNPRVGTKRYMAPELLDDSINTYHFESFKCADIYSLGLVYWEIARRCSVGGVVDEYQLPYYDMVPSDPSLEDIRKVVCEQKLRPSIPNQWQSFEALRVIGRIMRECWYANGKARLTSLRIKKTIAQLCVEEDYKL
The following text describes a protein:
Function:
Probably participates in deamination of adenosine-34 to inosine in many tRNAs.
Sequence:
MAAPMGDLGPCKKKMKVMTTADGDTSIAPASTASPGVNIPHPVPVLSDDIMAPVPLIDVYVAPVLDKKQTSRLIKEVSSRFPLPDLLHLKRVNSQKSGNKETTIQILLSKAPSSEDGSSADSESRDPTENGFHFDGLGKPFLTKVAVRPAITRRQYEHCVQYWPTAFHEDKLLERRLKGDFFTSEELQSIQKYMQRALQAAQHAKQTGMEPVGAVVVDPVADEVIGVGHDLRHAGNPLHHAVMVAVDTVASSQDGGYWDHRGPELYWREEQSETSNIHVKETADDCSLKGTETAGKDVKSEDSTRTSDISGNTEEQPKDGPYLCTGYDLYVTREPCIMCAMALVHSRIRRVFYGAPHPSGALGTRYSLHTQPNINHHYEVFKHVMLEECGSLKT
The following text describes a protein:
Function:
May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAVLGVQLVVTLLTATLMHRLAPHCSFARWLLCNGSLFRYKHPSEEELRALAGKPRPRGRKERWANGLSEEKPLSVPRDAPFQLETCPLTTVDALVLRFFLEYQWFVDFAVYSGGVYLFTEAYYYMLGPAKETNIAVFWCLLTVTFSIKMFLTVTRLYFSAEEGGERSVCLTFAFLFLLLAMLVQVVREETLELGLEPGLASMTQNLEPLLKKQGWDWALPVAKLAIRVGLAVVGSVLGAFLTFPGLRLAQTHRDALTMSEDRPMLQFLLHTSFLSPLFILWLWTKPIARDFLHQPPFGETRFSLLSDSAFDSGRLWLLVVLCLLRLAVTRPHLQAYLCLAKARVEQLRREAGRIEAREIQQRVVRVYCYVTVVSLQYLTPLILTLNCTLLLKTLGGYSWGLGPAPLLSPDPSSASAAPIGSGEDEVQQTAARIAGALGGLLTPLFLRGVLAYLIWWTAACQLLASLFGLYFHQHLAGS
The following text describes a protein:
Function:
Involved in assembly and/or maintenance of motile cilia. Required during spermatogenesis for axoneme elongation. Necessary for optimal function of the chordotonal (hearing) organs.
Subcellular Localization:
Cell projection, cilium. Perikaryon. Cytoplasm.
Sequence:
MSGAGEHSDEESYGEESFEEDSESEVEVEEEEIEYIEPEESKPSDALLLGESDTQSESDVKEEFLSGNPHARRYLGARVVSYLSSSSDDESQVVITKTVAEVNQLSLRVDTPPEDETPSVRTLMPGSAHSRVKDEDEAEDEDDDEGDGENDNDNEDENDDEDAEVEEIEEEEEEIPGDEDDAQSDGSMGRQSADDSDEEEGTDVEVEQLEEDEPIVTAVCKKTVQKELPPPQKDIVSLVDASDNSSEHSVVTMCASGDETDNTLVKYPRLRKQQPLTAKDSQSLKEQEEPEEPEQPEENQTEEHMPTSQPDLARVRYLEQQMTQMSELIMKSFQINGGAPNSQAFEQLAMATEMLQQRSDRRGDTESEMSSMTETTMTSARSLGGGIPPLTMRMERSQEALLTTRSSKLPRPKCRCPSESDLIEHEQKLDMGHELPHDLAANFGLGEGYLVDECGQGDGLMRHPQQRKPMELNRRAVSGTPSTFNSDGCEYQINVSRSRCSNDKINYKNLGRKSFSFTNPQVREIERQNQILLRKMMTVKPTATIKASTSSIKINGPEKRQTPPAPRLSSAAVNRKKNQRQIDLDNDLLKRKLEAIGTRRPQFK
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (camk4) activity; contributes to the regulation of camk4 signaling cascades. Plays a role in the regulation of definitive hematopoiesis via its effects on camk4.
Subcellular Localization:
Cytoplasm. Cell projection, cilium, flagellum. Cell projection, cilium. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, flagellum axoneme.
Domain:
The IQ domain mediates interaction with calmodulin when cellular Ca(2+) levels are low.
Sequence:
MTSVEELRACALLQDCADQLSVLGNIIRPGAETQQRTELHLKTAQLMAGSSLSNFSGELKSQKHFKIQQTLLASDNLAKVQKDRQFVSDVINALLEELQKKNNFQSLFSAVAEERKKKAELLDIINREEEGRRQIKKLQKQLLDIRKEKTEECERLEEEVAILKDQVQDMRVRTNQQGKFVKSCAEQLVYQESKHNSYKENELEDEVKMLQEKIEEEKNVHFETEAFLKQQHANLKQKLQYWIHRYEKDMEEKEQEITALQNKRNSSQTRIQDLSKKCKDMENVVIEDRIEKEHLRAQMEKEQREKNAATKIQAWWRGTLVRKGPRSKKADKSKKKDGKKGKKKRK
The following text describes a protein:
Function:
May have a photoreceptor function.
Sequence:
MSDSKILIYLMRRDLRVADNPILHSLIHNKDHGFTHLLPLYVFAAQQIEVSGFIPEDGGKSPYPEARSQLGAFWRCGPHRAKFLAQSVWDLKDGFEKIGSGLSIRVGMVDEIVKGLIERFEEGAGSKVSAVWMTSEEGVEEKREERSTKKICDKAGVDFKLWQDEKYFVDDRDLPFEDPKDLSDIYTTYRKSVEPLRNAPRPDLPKPEMNSLPPFPTDVPPQHSPFVIPTKYEEIEAALLKPINSQPLVKNPPKCPENTLSVHPFTGGESHAQERLEHLITSGSITGYKSSRNGLMGTDFSTKLSAYLALGSITSRQIHASMSVFENGSTSDDRYKDLEGYGNGENEGTYAVRFELLWRDYMRLCTRKFGPQLFRLGGFKAEGNAHSKWSRLDSPKDGFSKEQIQEIVERFLNGTTGMGFIDASQREIYHTGYTSNRARQNVASFLSKHLYIDWRIGAEWYECMLVDYDVSSNWGNWQYVAGVGNDPRGNDRIFNPVKQAFDYDPKAEYVLAWVDELRGVDELGQIFQAWTINDEEKKEELGIADTDMVKNPLKRIDFKVNRGRGGGVGGGGGRGGGRGRPPYRPHGGDRWMGRRPSPQDQGRGSWYGGRGDRGYQTRGYQGRGYRGRGDRGREMRTGMMDKEREATADNE
The following text describes a protein:
Function:
Plays an essential role in the initiation and regulation of chromosomal replication. ATP-DnaA binds to the origin of replication (oriC) to initiate formation of the DNA replication initiation complex once per cell cycle. Binds the DnaA box (a 9 base pair repeat at the origin) and separates the double-stranded (ds)DNA. Forms a right-handed helical filament on oriC DNA; dsDNA binds to the exterior of the filament while single-stranded (ss)DNA is stabiized in the filament's interior. The ATP-DnaA-oriC complex binds and stabilizes one strand of the AT-rich DNA unwinding element (DUE), permitting loading of DNA polymerase. After initiation quickly degrades to an ADP-DnaA complex that is not apt for DNA replication. Binds acidic phospholipids.
Subcellular Localization:
Cytoplasm.
Domain:
Domain I is involved in oligomerization and binding regulators, domain II is flexibile and of varying length in different bacteria, domain III forms the AAA+ region, while domain IV binds dsDNA.
Sequence:
MTLAEFWPLCLRRLHDMLPQGQFAQWIAPLTVGEEGGVWVVYGKNQFACNMLKSQFAGKIEAVREELAAGRSAFVFKPGEGVRYEMAAVEGAVEPAEPSLHAVSEGMPVQEVLLDELPSEEPVKPAASKTAADILAERMKNLPHEPRQAAGSASRPESVAVAKARTDVQRDAEEARYEQTNLSPDYTFDTLVEGKGNRLAAAAAQAIAESPGQSYNPFFLYGSTGLGKTHLVQAVGNELLKNRPDAKVRYMHSDDYIRSFMKAVRNNTYDVFKQQYKQYDLLIIDDIQFIKGKDRTMEEFFYLYNHFHNEKKQLILTCDVLPAKIEGMDDRLKSRFSWGLTLELEPPELEMRIAILQKKAEAAGISIEDEAALFIANLIRSNVRELEGAFNRVGASSRFMNRPVIDIDLARTALQDIIAEKHKVITADIIIDAVAKYYRIKISDVLGKKRTRNIARPRQVAMSLTKELTTLSLPSIGDSFGGRDHTTVMHGIRAVAKLREEDPELAQDYEKLLILIQN