lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Promotes apoptosis.
Subcellular Localization:
Membrane. Mitochondrion.
Sequence:
MCPCPLHRGRGPPAVCACSAGRLGLRSSAAQLTAARLKALGDELHQRTMWRRRARSRRAPAPGALPTYWPWLCAAAQVAALAAWLLGRRNL
The following text describes a protein:
Function:
Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfer of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors. Functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Regulates lipid droplet fusion.
Subcellular Localization:
Cytoplasm. Lipid droplet.
Sequence:
MAEKCGQHEEDSASKSLLGTRFKWCPTSLHNLAAAETKVLQYVKSRLERFYVPIPNGGRIWTLKVNPRKTDAFPIVMVHGFAAAAGFFFLNFDALAEHRTVYAFDVLGFGQSSRHKFSTKPDVVEEEFVDSIEEWRKGVGLEKFILMGTSFGGFLAASYAIKHPGRVKHLILADPWGFPEKTEQAAKKFRAETPFWMRIIAPMLPHINLLAPLRLAGPFGPQLLRAVRPDVRTKFADGFQDNTVIDYLYHCVAQPPSAETAFGTLQSEGWEWAKKPMLPRMTRLDPNVPITFIYGADTWMDSRTGKQTAILRKGSYVDIIFIQNAGHHMYAEQYRDFNRELLRVCRNTDRTQ
The following text describes a protein:
Function:
Orphan G-protein coupled receptor involved in the regulation of hair cell orientation in mechanosensory organs of the inner ear. It is required to trigger a 180 degree reversal in hair cell orientation, creating a virtual line of polarity reversal (LPR) across which stereociliary bundles are arranged in opposite orientations.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MEPEINCSEFCDSFPGQELDRRPLHDLCKTTITESQHSSTAASPLSPALLGIMWTFLSCGLLLVLFFLAFTIRCRKNRIVKMSSPNLNVVTLLGSCLTYISAYLFGIQDALEGSSVEALIQTRLSLLCIGTSLVFGPILGKSWRLYKVFTQRVPDKRVIIKDLQLLGLVAALVVADVILLVTWVLTDPIQCLQMLGVSMKVTGRDVSCSLTNTHFCASRYSDVWIALVLGCKGLLLLYGAYLAGLTNHVSSPPVNQSLTIMVGVNLLLLTAGLLFVVTRYLHSWPNLVFGLTSGGIFVCTTTVNCCVFIPQLKQWKAFEGENQTMRHMAKYFSTPSKSFHSQFDEDPSCHLRDEKSCMERLLTEKNAVIESLQEQVSNAKEKLVKLMSAECTYDSPEWAVPDAASARGLALPGPSECPAVSENESGAAARDSLHVPAACQHVQGPGASRRDTSPSPAQQDNMPLKQYCDHLDTGCNQKPKAEQSEGPERGDQEPMAPSQRLMADGVACEPHKPRQSPEGLPKKLPGVSSVVREKLQEVLQELDLGSEAPLSPLPCPQQLWKSTTSRSPQKLSPSKLGFSPYVVRRRRAAQRARSHIPGSVGLNVGHQANSTVSSSQSGLIVQNRDSPRLDHHNARSKVPRSSSVKPSPLSEPRRKQGTLEGSKQCETEPQEAGGACNVAFPCQSSASVQAQSPAAPCLPSSPALPRQRQPRPRLSPGCPSLSSGCYNLDSESSSSDEFFCRCHRPYCEICFQSSLDSNDSDTSDSDLEQASGLASWEKLWARSKPVVNFKDDLKPTLV
The following text describes a protein:
Function:
Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=May be localized to the nucleolus in an NPM1/B23-dependent manner. May be displaced from the nucleolus into the nucleoplasm in an CDKN2A/ARF-dependent manner. May shuttle back and forth from nucleoplasm to nucleolus.
Domain:
The N-terminal region (NRD) inhibits DNA-binding via its interaction with the C-terminal region.
Sequence:
MEGESSRFEIHTPVSDKKKKKCSIHKERPQKHSHEIFRDSSLVNEQSQITRRKKRKKDFQHLISSPLKKSRICDETANATSTLKKRKKRRYSALEVDEEAGVTVVLVDKENINNTPKHFRKDVDVVCVDMSIEQKLPRKPKTDKFQVLAKSHAHKSEALHSKVREKKNKKHQRKAASWESQRARDTLPQSESHQEESWLSVGPGGEITELPASAHKNKSKKKKKKSSNREYETLAMPEGSQAGREAGTDMQESQPTVGLDDETPQLLGPTHKKKSKKKKKKKSNHQEFEALAMPEGSQVGSEVGADMQESRPAVGLHGETAGIPAPAYKNKSKKKKKKSNHQEFEAVAMPESLESAYPEGSQVGSEVGTVEGSTALKGFKESNSTKKKSKKRKLTSVKRARVSGDDFSVPSKNSESTLFDSVEGDGAMMEEGVKSRPRQKKTQACLASKHVQEAPRLEPANEEHNVETAEDSEIRYLSADSGDADDSDADLGSAVKQLQEFIPNIKDRATSTIKRMYRDDLERFKEFKAQGVAIKFGKFSVKENKQLEKNVEDFLALTGIESADKLLYTDRYPEEKSVITNLKRRYSFRLHIGRNIARPWKLIYYRAKKMFDVNNYKGRYSEGDTEKLKMYHSLLGNDWKTIGEMVARSSLSVALKFSQISSQRNRGAWSKSETRKLIKAVEEVILKKMSPQELKEVDSKLQENPESCLSIVREKLYKGISWVEVEAKVQTRNWMQCKSKWTEILTKRMTNGRRIYYGMNALRAKVSLIERLYEINVEDTNEIDWEDLASAIGDVPPSYVQTKFSRLKAVYVPFWQKKTFPEIIDYLYETTLPLLKEKLEKMMEKKGTKIQTPAAPKQVFPFRDIFYYEDDSEGEDIEKESEGQAPCMAHACNSSTLGGQGRWII
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system YiaMNO involved in the uptake of 2,3-diketo-L-gulonate.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MAVLIFLGCLLGGIAIGLPIAWALLLCGAALMFWLDMFDVQIMAQTLVNGADSFSLLAIPFFVLAGEIMNAGGLSKRIVDLPMKLVGHKPGGLGYVGVLAAMIMASLSGSAVADTAAVAALLVPMMRSANYPVNRAAGLIASGGIIAPIIPPSIPFIIFGVSSGLSISKLFMAGIAPGMMMGATLMLTWWWQASRLNLPRQQKATMQEIWHSFVSGIWALFLPVIIIGGFRSGLFTPTEAGAVAAFYALFVATVIYREMTFATLWHVLIGAAKTTSVVMFLVASAQVSAWLITIAELPMMVSDLLQPLVDSPRLLFIVIMVAILIVGMVMDLTPTVLILTPVLMPLVKEAGIDPIYFGVMFIINCSIGLITPPIGNVLNVISGVAKLKFDDAVRGVFPYVLVLYSLLVVFVFIPDLIILPLKWIN
The following text describes a protein:
Function:
Controls stomatal patterning.
Subcellular Localization:
Secreted.
Sequence:
MGSFQIWHRNRNKHISILLLFLSVFILILVTSIEGRGIQAMEGERKSAEVATEEEEKMGMMMRNQIGSRPPSCRRKCRECGGHCEAVQVPVALHDSNQNQRKGRRKRRSSSRYFSVNSKHDVALSSEDETSNYKPISWKCKCGNFIFNP
The following text describes a protein:
Function:
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. ski6 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MNRIGILSRSDGSSEWKQGSARVICGVNGPIDVKIRDERLNKATVEVLVQPVSGVAETLEKMISSRIVGILEDAIFLNTYPRTLIQVSIQIIEEDGTDTLAAVINGAVLALLDAGISLKYIPCAINCHWKNKITQDEPDVDGTINKLESIITICYSISSEPAKLIFLETAGPIPEEDFFRVLETAPLHAEEVSKKMKELLFETYNESDGHENEKNPKEDVEMDVVA
The following text describes a protein:
Function:
Involved in the biosynthesis of aklavinone which is an important precursor common to the formation of the clinically significant anthracyclines such as carminomycin, daunorubicin (daunomycin), rhodomycin, aclacinomycin T (aklavin) and aclacinomycin A (aclarubicin). These compounds are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. Catalyzes the methyl esterification of aklanonic acid to yield aklanonic acid methyl ester.
Sequence:
MQDSSYKKQVTQAFDQSSSTYDRLGVEFFTPMGRRLVDISEPVTGERVLDIGCGRGACLFPAAEKVGSQGCVHGIDIAPGMIEEARKEATERGLRNISLMVMDAETPGFPARSFDLVMGSYSVIFLPDAVGALARYADILDHGGRIAFTSPVFRAGTFPFLPPEFTPLIPQALLEHLPEQWRPEALVRRFNSWLERAEDLVRTLEGCGYARLRQSTSRCG
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER. The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER. Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68. Can bind 7SL RNA with low affinity. The SRP complex possibly participates in the elongation arrest function.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum.
Sequence:
MASSGSGGVSVPALWSEVNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLANNSLSFEKAYCEYRLNRIENALKTIESANQQTDKLKELYGQVLYRLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHELCYNTACALIGQGQLNQAMKILQKAEDLCRRSLSEDTDGTEEDPQAELAIIHGQMAYILQLQGRTEEALQLYNQIIKLKPTDVGLLAVIANNIITINKDQNVFDSKKKVKLTNAEGVEFKLSKKQLQAIEFNKALLAMYTNQAEQCRKISASLQSQSPEHLLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENAAEIKLTMAQLKISQGNISKACLILRSIEELKHKPGMVSALVTMYSHEEDIDSAIEVFALAIQWYQNHQPKSPAHLSLIREAANFKLKYGRKKEAISDLQQLWKQNPKDIHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLKVDVEALENSPGATYIRKKGGKVTGDSQPKEQGQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERSYYRGRKKGKKKDQIGKGTQGATAGASSELDASKTVSSPPTSPRPGSAATVSASTSNIIPPRHQKPAGAPATKKKQQQKKKKGGKGGW
The following text describes a protein:
Function:
RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs.
Subcellular Localization:
Cytoplasm.
Domain:
The horseshoe-shaped TROVE domain is built with 7 helical HEAT-like repeats, and is closed by the VWFA-like domain giving rise to a ring-shaped monomer. Single-stranded RNA is bound in the positively charged central cavity (By similarity); The MIDAS-like motif in the VWFA-like domain binds divalent metal cations.
Sequence:
MADELNEFQEAGNFNEEALMRLSNVCARLRRMQMLESDVEITVVDGELKRVPRQMEKVKDGQVENNAGGFVFPVSDETQVRRFLILGSDKGSYHQSSEKITIDNAQRIIKIIEQGNGHMVLKELALINAENRNPKMNAMIFTLAICARISTHDTTKKTECPMLNAYSDYIRALHDSALDLIPEVCRTPTHLFEFVDYCQTISESTKAGGAKSSTGWGRSMRNAISKWYTTKTTEKLAMLLTKYPQREGWSHRDLFRLAHPNLMDSRSHGQSEDRLEREQLFRFAVKGDLVKRKRKMSVEEVAEVEKVWDKKALKLPYTEEQLIKEEQSRALNLVEAYLKLKNEQSEEVIVAAIKKHGLVREHLPTTSLNSKLVWETLFDVSMPMTAMIRNLAKMTVVGALDEKRVDNIVKRLTDQEELRRSRIHPINLLTARAVYAQGRGDKGSLTWEPNQKICDALEAGFYKAFVNAPPTGKRYCLALDVSGSMTSRVSSSPLSCREAATGMSLINLHNEAEVRCVAFCDKLTELPFTKDWKIGQVNDYVNNLDFGRTDCGLPMTWATENNLKFDVFIIYTDNDTWAGEIHPFEAIKKYREASGIHDAKVIVMAMQAYDYSIADPSDAGMLDITGFDSAVPQIVHEFVTGKI
The following text describes a protein:
Function:
Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=The 145 kDa plasma membrane form of GUCY2C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MTSLLGLAVRLLLFQPALMVFWASQVRQNCRNGSYEISVLMMDNSAYKEPMQNLREAVEEGLDIVRKRLREADLNVTVNATFIYSDGLIHKSGDCRSSTCEGLDLLREITRDHKMGCALMGPSCTYSTFQMYLDTELNYPMISAGSYGLSCDYKETLTRILPPARKLMYFLVDFWKVNNASFKPFSWNSSYVYKNGSEPEDCFWYLNALEAGVSYFSEVLNFKDVLRRSEQFQEILTGHNRKSNVIVMCGTPESFYDVKGDLQVAEDTVVILVDLFSNHYFEENTTAPEYMDNVLVLTLPSEQSTSNTSVAERFSSGRSDFSLAYLEGTLLFGHMLQTFLENGENVTGPKFARAFRNLTFQGFAGPVTLDDSGDIDNIMSLLYVSLDTRKYKVLMKYDTHKNKTIPVAENPNFIWKNHKLPNDVPGLGPQILMIAVFTLTGILVVLLLIALLVLRKYRRDHALRQKKWSHIPSENIFPLETNETNHISLKIDDDRRRDTIQRVRQCKYDKKKVILKDLKHSDGNFSEKQKIDLNKLLQSDYYNLTKFYGTVKLDTRIFGVVEYCERGSLREVLNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQATISQKGDVYSFAIIAQEIILRKETFYTLSCRDHNEKIFRVENSYGKPFRPDLFLETADEKELEVYLLVKSCWEEDPEKRPDFKKIESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADHLNFMLLPRLVVKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQIVDHHDVYKVETIGDAYVVASGLPMRNGNRHAVDISKMALDILSFIGTFELEHLPGLPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTITILKRTDCQFLYEVRGETYLKGRGTETTYWLTGMKDQEYNLPSPPTVENQQRLQTEFSDMIVSALQKRQASGKKSRRPTRVASYKKGFLEYMQLNNSDHDSTYF
The following text describes a protein:
Function:
Protein-histidine N-methyltransferase that mediates methylation of RPL3 at 'His-243'. Methylates ribosome-associated RPL3, but not free RPL3, thereby regulating 60S subunit assembly. In addition to RPL3, mediates His methylation of other proteins.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSFSFGFTSNDFDDDELVAQPETFVESSKENENTTAYINPLDSDFLSQAGVVQPNVEDLGTILESLKDVRLTFEEFQSPIYRKPLIKRELFDVKHQLMLETDAQSNNNSTELDILLGDTSEDLRKNIYEGGLKSWECSYDLVDLLSENVDRISNDIDAVVEIGCGTALPSEFLFRSALLRNDRSKGLKFVLTDYNASVLRLVTIPNLVITWAKTVLTKEQWYALQKDECEDIPINNEELLLTSKLLAAFYDDVQSRNISVTLISGSWGRKFSNLIHEVLSGSQKVLSLSSETIYQPDNLPVIAETILDIHNLPQTDVKTYVAAKDIYFGVGGSITEFEAYLDDKINSEHLPIHSERFKVNSGLKRSIICIETNKAIR
The following text describes a protein:
Function:
Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Binds to N-glycolylneuraminic analog of the ganglioside GM1 on the cell surface to provide virion attachment to target cell. Once attached, the virion is internalized by caveolin-mediated endocytosis and traffics to the endoplasmic reticulum. Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby triggering initial uncoating. Next, the virion uses the endoplasmic reticulum-associated degradation machinery to probably translocate in the cytosol before reaching the nucleus. Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2/Vp3 nuclear localization signal. The assembly takes place in the cell nucleus. Encapsulates the genomic DNA and participates in rearranging nucleosomes around the viral DNA. The viral progenies exit the cells by lytic release.
Miscellaneous:
MISCELLANEOUS: [Isoform VP1]: Produced by alternative splicing of the late mRNA (16s mRNA).
Subcellular Localization:
Virion. Host nucleus. Host endoplasmic reticulum. Note=Following host cell entry, the virion enters into the endoplasmic reticulum through a calveolar-dependent pathway. Then, viral DNA is translocated to the nucleus. Shortly after synthesis, a nuclear localization signal directs VP1 to the cell nucleus where virion assembly occurs.
Domain:
The intrinsically disordered C-terminal arm interacts with neighboring pentamers. The unstructured nature of this region allows to make different interactions depending on the structural context: pentamers present at the 12 icosahedral fivefold axes bind five pentamers, whereas pentamers present at the 60 icosahedral six-fold axes interact with six pentamers; A DNA-binding domain overlapping a bipartite nuclear localization signal is present in the N-terminal region of the protein and is required for efficient virus formation.
Sequence:
MAPTKRKGSCPGAAPKKPKEPVQVPKLVIKGGIEVLGVKTGVDSFTEVECFLNPQMGNPDEHQKGLSKSLAAEKQFTDDSPDKEQLPCYSVARIPLPNINEDLTCGNILMWEAVTVKTEVIGVTAMLNLHSGTQKTHENGAGKPIQGSNFHFFAVGGEPLELQGVLANYRTKYPAQTVTPKNATVDSQQMNTDHKAVLDKDNAYPVECWVPDPSKNENTRYFGTYTGGENVPPVLHITNTATTVLLDEQGVGPLCKADSLYVSAVDICGLFTNTSGTQQWKGLPRYFKITLRKRSVKNPYPISFLLSDLINRRTQRVDGQPMIGMSSQVEEVRVYEDTEELPGDPDMIRYIDEFGQTTTRMQ
The following text describes a protein:
Function:
Involved in the lipid remodeling steps of GPI-anchor maturation.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MLIRFTSMEQCYKTGCVGQKSFQHCQFLSNAKPIDGPWYLQEPLYLQWKQWDCHSGCPYNCLVAGRRQELGDKPIMYRGNGHLNVFMEFSKCVCASQEPVSVAVSALPIAIQFHGFVHFEFTGLWHVYEILSMNSWFWSAFHSRSRGHYPVMVLKQGSEWKILAHSCNIIFTFKTLMILQAFNVRIEAASIMVAAPLIASLATHIMYLNVYDLDCGLNMKVCGAMGLTQLLIWASVTHHASRCKLWMVVVGGGLAMLLDTIRLPTISRIC
The following text describes a protein:
Function:
As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.
Subcellular Localization:
Secreted.
Sequence:
MAGPLRAPLLLLAILAVALAVSPAAGASPGKPPRLVGGPMDASVEEEGVRRALDFAVSEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHEQPHLKRKAFCSFQIYTVPWQGTMTLSKSTCQDA
The following text describes a protein:
Function:
Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein.
Sequence:
MADDEDREALLPEAAGSRKRDMAAICDPSRFAHRMLVLALMCFLGFGSYFCYDNPAALQTQVQADMKVNTADFMQLYAFYSWPNVVLCFFGGFLIDRVFGIRLGTIIFSLFVCAGQVIFATGALVNSFLVMEVGRLVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARVANGAIRNVITATCEVIKITDVKDFSLSLWLIFIICVCYYVAVFPFIGLGKVFFIEKFQFSPLQAGAINSVVYIISAPLSPVLGFMVDRLGKNIIWVMCAVVATLASHLMLAFTFWNPWIAMSLLGVSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIIAIVAGVILDSRGYLFLEVFFSACLCMAIIAVVMLYFVNLLRGGDLNLSAWEREKLQKQAAVEAEKEQMKRRNSDWARIRPMSAFAVRVRYLSRLGAQLPEHYCSHLSSLAHRSVLK
The following text describes a protein:
Function:
May regulate cell growth likely by suppressing RB1 phosphorylation (By similarity). May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages. Serve as a tumor suppressor in certain leukemia cells (By similarity). Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, P-body. Note=Colocalizes with ZC3H12A in GW bodies (GWBs).
Sequence:
MEHRSKMEFFQKLGYSQEDVVRVLGKLGDSALVNDVLQELIQTGSRPRAQEDPASGTGVVLIPRGCCGVQDSAQQGPGTRPRRGWRRSSPLLRPIVIDGSNVAMSHGNKEAFSCRGIRLAVDWFTDRGHTYIKVFVPSWRKEPSRSDTPIREQHVLEELERQAVLVYTPSRKVNGKRVVCYDDRYIVKVAYEKDGIIVSNDNYRDLQNENPEWKWFIEQRLLMFSFVNDRFMPPDDPLGRRGPTLSNFLSKKPRPPEPSWQHCPYGKKCTYGVKCRFYHPERPHHGQLSVADELRAKTRAWLGGGAEEPRTPSARSRPTTARLLPQEPGEHDLPPAPQPAVLAALNRSFARLTFSDTAASGVVSQSRGPDWMPTGVPTSWAPPSLRAGSAATIGLPGMRSLRTPNNPLSPGDLGSPICPQARLSERHRSRDMHSDLPPQRRPLEDPWALLPSSYCYLNHSVWSESAWGEDIFRGPSESAQPVANGGGTRPVHCSFFPPDQDHPVMASGPPLSDMALLTLLQRSQKTGAPLGDP
The following text describes a protein:
Function:
Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSTPSEYKLPEYTVKDYASFALAGAIGCGATHGAMTPIDVVKTRIQLEPTVYNKGMLGSFKQVIKSEGAGALLTGLGPTILGYSLQGAFKFGGYELFKKTFIEYLGYDTAKQYKDSIYIGSSALAEFFADIALCPLEATRIRLVSQPTFANGLIGGFSRILKEEGVGSFYNGFTPILFKQIPYNIAKFLVFERANEAIYNAIPTPKVDLSTAAHTAVNLGAGIIAGCAAAIVSQPADTLLSKVNKTKKAPGQSTVGLLIQLAKQLGVSGSFAGLPTRLVMVGTLTSLQFTIYGSLKKALNCPPAVAL
The following text describes a protein:
Function:
May transport inorganic phosphate (Pi).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKFGKQFETQQVPEWREAYLDYRQGKEIVKHMAKIKKQWQEESEPHLSRRISNFRRLVSGFQHAHSPRGARSPTSEEEMILIEPKQTSDGMEFQTAFLGDGSPHDELERTFFWLLDKELAKLNKFYKSKEKELVTQATALDSQMEALLSAKKSVDNLDAGNGESNASSHGRLSVVEEDGGSVRQIKIDIPAAKPADALAALFAELANKSITNLNSRRLKRAEEMLQNAFVEFYKGLYILRNFCSLNIIAFSKLLKKYNKVTQRNLGRKYMKAVEDSYIGQSEIIQKLMEKVEVLFTKHFTDSNRRDAMQVLRPEARKERHRISFFVGVFFGLSVALLVSLVLTIRVERLYVREYATTYMDAVFPIFSMLTAVLLHFFLYGLNIYMWRRTRINHTFILGLNRKSELRFRDVFLLATWLSTLALSGLILHLQVTAGEICCQTYQEIIPLLVVAGMVVLLFMPFNILYRATRYFFLNALWHCLLTPFYKVIITDFLLADQLTSQVPALRDLEYVLCYFGGGFFKDRNSNACLKNPTFITFGFVMALLPYWCRFSQCLRRWHDEKDVMQLYNALKYFSAILAVAARLAYGYYKDPVLLGFTIAISATAAIVSTYWDLVYDWGLLERNSANPWLRDKLAIPYKSVYYFAIVSNILLRFAWLQSLIPISMPGINPKGLSLIVASLEVIRRGQWNYYRLENEHFNNVGKFRAVKSVPLPFVD
The following text describes a protein:
Function:
Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process, increasing the linking number in steps of +1; also positively supercoils with dATP and ATP-gamma-S. With UTP or dTTP relaxes negatively supercoiled DNA, in the absence of any nucleotide partially relaxes negative supercoils. In the absence of nucleotide has a higher affinity for dsDNA with a single-stranded tail than dsDNA or ssDNA. Has an ATPase activity in the absence of DNA. Binds to single-stranded DNA, transiently cleaves and then rejoins the ends, introducing a positive supercoil in the process (Probable). The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate (Probable). Probably involved in rewinding DNA strands in regions of the chromosome that have opened up to allow replication, transcription, DNA repair and/or for DNA protection.
Miscellaneous:
MISCELLANEOUS: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea known and seems to be essential for adaptation to life at high temperatures. It may play a role in stabilization of DNA at high temperatures.
Subcellular Localization:
Cytoplasm.
Domain:
Introduction of positive supercoils requires the cooperation of both domains. The helicase-like domain probably does not directly unwind DNA, but more likely acts by driving ATP-dependent conformational changes within the whole enzyme. A beta hairpin in the 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
Sequence:
MALATGAKYYHSCINCGGINTDTRNEKGLPCEVCLPFEDGDVLKGLKLNNSLKGYEKYWNLNQQYKEFEEFFFSKINKKPTGYQRFWAKRLLLSKSFTLVAPTGVGKTTFGLISALWIAKKGGKVALVFPTVSLVEQAAKRLIEFSKEDEDVNILFYTSSLKKKEREKFEKNFSEGNYDILVISSQFISKRKEQLSQKVFDLVFVDDVDAVLKSSKNIDTLLNMIGISQKAIDSTLDNLKKGNNSDKIQIEEKAPKGRLIVSSATAKPKGIKPLLFRELLGFEIGRFTTSARNITNVRIKEKSLEKLLYIINLLKDGILLFVPTEEEGKEIANYLEEHGVKLGKTWEDFEKSFEKFKEGSLQLLCGIYSYYGKLVRGIDLPLRIKFAVFWGTPSFKFSTKLENAPRFILERNFQDYLENNPKLKAYFKDLQRLSTEKLRKSVEKYISPETWEKLIQKNFPTTKFDKEKNLIVIPDVYTYIQASGRTSRIFGTSLTKGISILFEEDDSLFELLKARLLYLTEEEWTEEGEIEHLVKEAEETRKAISTDSSSKDMKSRMIIVESPTKAQTISKFLEKSSTRRYGSLMVHESITQEGILLLTASKGHLYDLETKTGLHGVEINDGRFIPYYNSIKRCSSCGAQFTDELPRCPYCNSDKIDDKKKILEALRDIAMEVDEVIIATDPDVEGEKIGWDISQYIKPVNKNVQRIEMHEITKFGFDKAIRNRRNCDVNLVKSQIVRRIEDRWVGFELSLRLQKNFQNSNLSAGRVQSTVLGWILEKEIEHSKSKKTVTQFTLDNGFKFEVDGKIDVDEVEVEIVEEKEQALSPLPPFNTPSLLTAASQQFKLPVQQIMEILQTLFELGFITYHRTDSTRISSTGQKIARSYLEKIGKITLLSEREWGKEGAHEAIRPVKPISPEELSEFITEKIAAYLSPMHIKVYSLIFNRFMASQMTSPVVINQKILIKNGSFQVEREVPVKLQEEGWNIFNPITVYTPFEEKKYSVVSKRTYTTHTVPLFTQASLIEEMQKRNIGRPSTYAKIVDILFKRKYIIEDVYKRLRTTALGRKVYSYLSERYMNYINEETTRQLEKLMESVETGEKDYQSVLKNLYEELNEILIKN
The following text describes a protein:
Function:
Plays an important role in the processing of non-canonical mitochondrial mRNA precursors.
Subcellular Localization:
Mitochondrion matrix, mitochondrion nucleoid. Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids.
Sequence:
MAATLKSLKLVRYRAFCSPSAFGAVRSVSYWNVSSTQHGGQDPPEHISLCHSAKKVKNICSTFSSRRILTTSSAHPGLEFSKTSSSKASTLQLGSPRATGVDEEDVEVFDSFENMRVFLQLRPEYRVHSYNASETSQLLSVSEGELILHKVRVNQNNLQAQVIVDYLCKLSSLPAEQHPVLLGSTSFALLCQLSVKKIQLFDTQDLINVLKAFVILGIPHSHSMLDVYETKCCHQVWEMNMDQLLLVADLWRYLGRKVPRFLNIFSSYLNLHWKDLSLSQLVHLIYVIGENRQVSQDLMQKLESLILKYIDLINLEEVGTICLGFFKSSTNLSEFVMRKIGDLACANIQHLSSRSLVNIVKMFRFTHVDHINFMKQIGEIAPQRIPSLGVQGVMHLTLYCSALRFLNEGVMNAVAASLPPRVAHCRSKDVAKILWSFGTLNYKPPNAEEFYSSLISEIHRKMPEFNQYPEHLPTCLLGLAFLEYFPVELIDFALSPGFVRLAQERTKFDLLKELYTLDGTVGIECPDYRGNRLSTHLQQEGSELLWYLAEKDMNSKPEFLETVFLLETMLGGPQYVKHHMILPHTRSSDLEVQLDVNLKPLPFNREATPAENVAKLRLEHVGVSLTDDLMNKLLKGKARGHFQGKTESEPGQQPMELENKAAVPLGGFLCNVADKSGAMEMAGLCPAACMQTPRMKLAVQFTNRNQYCYGSRDLLGLHNMKRRQLARLGYRVVELSYWEWLPLLKRTRLEKLAFLHEKVFTSAL
The following text describes a protein:
Function:
Compacts the host nucleoid. Probably dysregulates hundreds of host genes including derepression of most of the H-NS regulon. Plays a role in the transcriptional regulation of middle promoters.
Sequence:
MIINIGELARVSDKSRSKAAGKLVEVVSIQLKHGVKDEDSEVKVRIIPKDGKSKPQFGYVRAKFLESAFLKAVPAKGIETIDTSHVGVDFKWKLGQAIKFIAPCEFNFIKDDGRVVYTRAMCGYITDQWVEDGVKLYNVVFLGTYKVIPESWIKHYSNALYA