lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
It uses activated amino acids in the form of aminoacyl-tRNAs (aa-tRNAs) as substrates to catalyze the ATP-independent formation of cyclodipeptides which are intermediates in diketopiperazine (DKP) biosynthetic pathways. Catalyzes the formation of cyclo(L-Leu-L-Leu) (cLL) from L-leucyl-tRNA(Leu). Can incorporate various nonpolar residues, such as L-phenylalanine, L-leucine and L-methionine, into cyclodipeptides.
Sequence:
MLHENSPSFTVQGETSRCDQIIQKGDHALIGISPFNSRFSKDYVVDLIQWSSHYFRQVDILLPCEREASRLLVASGIDNVKAIKKTHREIRRHLRNLDYVISTATLKSKQIRVIQFSDFSLNHDYQSLKTQVENAFNESESFKKSCLDMSFQAIKGRLKGTGQYFGQIDLQLVYKALPYIFAEIPFYLNTPRLLGVKYSTLLYHRPWSIGKGLFNGSYPIQVADKQSYGIVTQL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
Sequence:
MQGAGAAEGRSRGSPSTMDKADESAKKARLDLPDAHSVKQELVAHDAAAGAGAIVAVPEHSPRAELAVKIDMCVLHCPLCALPFKPPVFQCKGGHLACGGCAAQQPSGQCGACADGCGFFDPCPALDAVVSSTRVECPNAGCQRYVTYHEADEHRGACAHAPCRCTEHGCAFVGAAPDLAGHLSAAHSVPVRAIRYGKVSRLQVPVSTPRQLLVGDDDGRVFVLTVGALGAAATAVSVVCARGSAATRPRFTCKMWVNLTTSAAANGGKADTVLVEMQMRSSTSPGAMVAAGEPTFLAVPPAYLVPGADGGDGAAGMEVPLSVRIDKIAPWSD
The following text describes a protein:
Function:
Transcriptional coactivator that together with FHL1 regulates the expression of rRNA and ribosomal protein genes. Its activity is negatively regulated by environmental stress.
Miscellaneous:
MISCELLANEOUS: Present with 1430 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MAGKKSPRKSTINHSTHSGKLPANIKRLIKKGESDTKSRQSPPTLSTTRPRRFSLIYSSESSLSDVSDSDKNKSTNPHKIKRKAKNISNNSQGKKSKLIQRQIDNDDEGTESSDYQAVTDGEESENEEEESEEEEEDDDEDDDDDDDDGSDSDSDSETSSDDENIDFVKLTAQRKKRAMKALSAMNTNSNTLYSSRENSNKNKSVKLSPKKENEEEQKEEKEKEKEEQQKQQESNKKEVNGSGTTTTQQALSFKFKKEDDGISFGNGNEGYNEDIGEEVLDLKNKENNGNEEDKLDSKVMLGNNDELRFPNISESDESEYDIDQDAYFDVINNEDSHGEIGTDLETGEDDLPILEEEEQNIVSELQNDDELSFDGSIHEEGSDPVEDAENKFLQNEYNQENGYDEEDDEEDEIMSDFDMPFYEDPKFANLYYYGDGSEPKLSLSTSLPLMLNDEKLSKLKKKEAKKREQEERKQRRKLYKKTQKPSTRTTSNVDNDEYIFNVFFQSDDENSGHKSKKGRHKSGKSHIEHKNKGSNLIKSNDDLEPSTHSTVLNSGKYDSSDDEYDNILLDVAHMPSDDECSESETSHDADTDEELRALDSDSLDIGTELDDDYEDDDDDSSVTNVFIDIDDLDPDSFYFHYDSDGSSSLISSNSDKENSDGSKDCKHDLLETVVYVDDESTDEDDNLPPPSSRSKNIGSKAKEIVSSNVVGLRPPKLGTWETDNKPFSIIDGLSTKSLYALIQEHQQLREQHQRAQTPDVKREGSSNGNNGDELTLNELLNMSELEDDSPSHTDDMENNYNDAINSKSTNGHAADWYEVPKVPLSAFRNKGINAYEEDEYMIPANSNRKVPIGYIGNERTRKKIDKMKELQRKKTEKKRQLKKKKKLLKIRKQRQKAIKEQETMNLQLGINGHEIIGNNNSHSDINTGTDFTTNENTPMNELPSHAPEDASLIPHNSDLAVDSNTRKNSTKSVGLDEIHEILGKDENDLLSVGDINGYDAQEGHVIEDTDADILASLTAPVQFDNTLSHENSNSMWRRRQSMVEAAAENLRFTKNGLFSESALADIEGIMGNDVNHSFEFNDVLQ
The following text describes a protein:
Function:
The NADP dependent reduction of PAPS into sulfite involves thioredoxin which probably plays the role of a thiol carrier.
Sequence:
MPAKMHSNYPSDSETAELRDSTESGYVSGGSSEEYLPEIVFTKPHLQFLNRQLQFLEPQDVLRWCVTSLPHLYQTTAFGLTGLVIMDMLSKLSIPRPQMVNLIFLDTLHHFPETLKLVDNVRKRYPLQHIHVYKPQGVETEEEFAKKHGERLWEKDDQLYDWIAKVEPAQRAYRELNVHAVLTGRRRSQGGKRGDLDIIEVDEAGLIKINPLANWTFDQVKQYVKENDIPYNELLDKGYKSVGDYHSTSPVKENEDERSGRWKGQAKTECGIHNPRSKYAQYLMDMERKRQEEALSQALQNKLTTA
The following text describes a protein:
Function:
Demethylates proteins that have been reversibly carboxymethylated.
Sequence:
MNLDSVLKPILEEEGGTTETLYKKKQLQKQEWNKYFDTMVIVNVQLSKLMQGTPVYSIMKHEPIVLLIHGAGHCAMTFALLCQQLKTFCSCISYDLMQHGQSLKTEPLEMDNLIKECEDVIDYIRLNNPNTNILLLGHSLGAAIACKLQPKSFIRGLIVIDMIESRAIESIQLMEKELRKRPSQFYSYSSAISYHLSNNLIKNPQSAQITVPHYLNDNLEWKVDLIQTKKYWQEWFKGIQDGFDNFQHSKLLFVAESNRLCSIQFKQQRYKIHLFDQSGHSMHEDEPERMAKLISDFILQEKIPINSDETEKLNSLGQQNFETKALSYEKQLKHVI
The following text describes a protein:
Function:
Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MPPKAKAKDAGPVERPILGRFSSLLKIGIVGLPNVGKSTLFNTLTKLSIPAENFPFCTIEPNEARVNIPDDRFDWLCQLYKPKSEIPAFLEIHDIAGLVRGAHEGQGLGNNFLSHIRAVDGIFHVLRAFEDPDIIHVDDIVDPVRDFETITEELRLKDIEFIKKKIEDVEKSMKRSNDKALKVELELLLKVKAWLEEGKDVRFGDWKAADIEILNTFQLLSAKPVVYLINMNERDYQRKKNKFLPKIHAWVQEHGGDTMIPFSGVFERTLADMLPDEAAKYCEENKLQSALPRIIKTGFSAINLIYFFTAGPDEVKCWQIRRQSKAPQAAGAIHTDFERGFICAEVMKFEDLKELGNETAVKGAGKYRQEGKTYVVQDGDIIFFKFNMCQSRYNRWFGSTGKRLMRKQTRSRKRIDYSTQLHASRINHLQSQDDIVTSMKDSVAKDLLRVSNNKNAYKKLSRVSSLRAISNKVVESIIEDAKKHYAEKAKVASPNKTIEEKVFLPPPPNPKLPDSHDLHWGGGKIVCKNTLDIDFRKKLPQIGLYEEGIAFVKFVYIKGNGLVTGDDHGKITSLGAEKTTIDLYLVHHLEDCVKFKTNKRETPLYELDSGKKYSFEEKGHKITGFHGRATADVIYSMEAISRTI
The following text describes a protein:
Function:
Required for normal Golgi function.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MTANLLNLNVDTLFEQHSVSEIDEVHKKIQSVVENKREELRTHVGERYRDLLQAADTIAAMQTSAGTLMEQVRHVQANCRSLNEQQLLGFQSTANASAKDAALKERNAGKKLQTYYGTMAQIKLLTALPELIWTHLDNDRFYAATELFIFSRHISTGLQLDGQSALMQKLPVARKQWEILRPFHVTIKQAILTALEREELLQEMTVDCLQSLLLLDKSDLSTVLKSFLNLRSSAFLNCLQSGPSEPRRVKDRILASLNVLNSTVELLDKCLLGYSLLFSRLEECASSTCPPSINRMESSERQLVHLLPEIIAGFKPQFDVPQLTPEQLGSSLQQWLDKMNALAAAHLQQVFALVTNMQTIQDIKSAARTNGRPDFVRLEQQLHLKRSQLDFYARKYVPLINARVREIIRSSWASAMKLTYEQVLLLIEAGQSQPPLQIWREQSDDLPLSLAAALSDQPKRLANRTKGYDGATIELCKRFDSHLADIVQELNVMLQEQTTRAEDKVSLIEFLRETAEEQLTEYLSNLKGLELRERPALLLALRNSLALVELCPNLKLCFCQPSSWRQWTDNSAGLGIEHWQRICGLIEKEMLSFWLVIVDDVLAGHNCEEKLPKVINHEVVLSDFALWQTLTLEQRDEDQEQSVQSTIRIPSQPRLSLQTYLHQLIQALNSVVPQTLPPKVLQAFIQRLIGKLLCHYEGLAHAECTKASQNIALQLYFDLKFLERVFAISREERTLYDQIHAQQNQLRDYIDPFDFELFAEHITAHVSRAASRLQGELGVLTPSAAAPSQGAAAASSLAHEADPNVLCLSSSGSTSLWFPLLPIVMPQAAGRVTSAERKSPIQEPVEKTATTTPTRKSGGNGARKGDSSKSKSSAASFFGMSQEWFR
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (By similarity). Required for mitochondrial protein synthesis. Has a role in mitochondrial integrity and cell respiration.
Subcellular Localization:
Mitochondrion.
Sequence:
MRNSVEFSQLGLKTAFNLSQNKTYTSAVKKQFFSTGAFLSNGGNIDLNKHTQKNIDSKYVACNSRSVTPPNDVASSVSKNTLRHKQRLMMAQWLMSPEVQKAKSSSSGNVGLGPNTNQPFPLNPFFKPPRPISHSLRMKITDEYLQGASIEVLARKFNTSPQRIEALIKLRRINDEFEEKKKPILHSYNEVMEKMLNACTKPEMMQFNDGNDIPLRSNPVSLWKSLPEGETFTPQEAAKILKWPSIEELNMRQNATHFHKTSDEHKDLNEDEELISSSPSEVGKRVFRLIDLSTGNVYRRDTGGDIYVKRKKSTT
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAPKSKKQAATQSKSKKSKDLVDERFQAIVLTDSFETRFMPLTAVHPRCLLPLANVPLIEYTLEFLANAGVNEVYLMCSAHADQIQEYIENSKWMGDNSPFSVTTIMSIESRSVGDTMRDLDNRGLIAGDFLLVSGDVVTNMDFSKALQFHKQKKAQDKDHIATMVLNQASPLHRTRSQIDPAAFVLDKETNRCIFYQSIPPVSGKKTCISIDPELLEDFQGELQVRNDLIDCHVDICSPHVPQIFQENFDYQYLRSDFLKGVLTSDLLKKTIYAYISKDSSEYAARVESWSTYDAISQDILARWCYPLVPDSNLVEGNSYSYELNNIYKEDKIILAQSCKIGTSTSIGRNSSVGEGTQIKNSVIGRNCTIGKNVVIENSYIWDNAVIKDNSVLNRSIVAADAQIGNNVTLSPGSVIGFNVIIGDDKVIPHNVKIVETPIVTENEFGDFDDESNSEDENEYEDGNAVPVLAVKDVELVGETGKGFAYESEIESGDEDDEEFVGNGTYSGIIYQMKSLNVSDDSIASVSNKKVKKHSHRRRLSMNSMISDNGGAFESDEGEEEEDFGVEGLATVTRAIENNHDIDTALLELNTLRMSMNVTYHDVRSVTTQALVNKIVDFITTGTLTPQEAATKIFTKWGIMFKRQVFSPEEEVDLLNIVEEKSSVLDKAYNQIVLFLGVKSFYDMEVVEEENILKWWNDGENDEVRTLAAKFITWLQEADEEDSDEDDEDSE
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.
Sequence:
MLINTSQNTKRAKSRKIETEENRRANRTQMEVPGSSKKMIATQAEMVSNKVPLAYRDQCAHLLIPLNKCRQSEFYLPWKCEDERHSYEKCEYELVMERMLQMQKIREEEARSKQKSPAQTQQPIPLIPKTVNA
The following text describes a protein:
Function:
GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42.
Subcellular Localization:
Cytoplasmic vesicle.
Sequence:
MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVSSNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGSPEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGHETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESLENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNLPLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEASPASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAAFSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEVEEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGEDKQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEEKSKGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAEEKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKERESGDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEMEPEGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVAPANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRTQTCTEGGDYCLIPRTSPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDPLLSSQRRSYAFETQANPGKGEGL
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
MATEQPKPAAEDVKMDLFEDDDEFEEFEIDQEWEDKEEGKEVTQQWEDDWDDDDVNDDFSLQLRRELESNTEKK
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MSGSSNVAAMKKVVQQLRLEAGLNRVKVSQAAADLKQFCLQNAPHDPLLTGVSSSTNPFRPQKVCSFL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MYSSSGSLVVHKIAVHSENGNVFKCDLCVKFFRNKESLNMHNQSIHSRNSVTCETCERVFRSMIYLNAHKRNVHTGKKWECDLCEKSFNTKSYLGAHKKTVHTGKKMQCDLCEKSYKTMKILDVHKRNVHTEKKWECETCEKVFRSMLYLNAHKKTVHTGKKWECDLCEKSFNTKSYLGAHKKTVHTGKKMQCDLCDKSYKTKGNLDAHKRTVHTGKKVECDLLPLSLSALPLDVHSLQHTVPLNTINPQTETSADMLEIPGKGRCYVYLAKYTYDPFTQSPNDNPEAEVSLASGDYILVWKTMDGDGFYEGESLDGRKGLVPSNFIKRLQGEDLVKFNRAAVLGLQICGDDSSKTTSPRDLLGVSPNHKQSSMSSHFEGKWDYRNRRPMRAYDSSRVGHPSINQLPSLPHQHLQQQLQQHQQQQILPHQQVITNNNPIEQGESNVKKTRFSNLKNIQIQYSDL
The following text describes a protein:
Function:
Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
Sequence:
MAVHPIDYRYGSEEMRRIWDEENKLQKLLDVEAALARAHAKVGNIPEESARVISERANTKWVKLERVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVERDLKELRSVLKRLAMEHKYTVCIGRTHGQHAVPTTYGMKFAIWLDEVQRHIDRINQLKERVLVGQMSGAVGTMASFGERGLEIQRLVMEGLGLKPARITNQIIQRDVYAELMMVLALIASTLDKIALEIRNLQRTEILEVSEPFGKKQVGSSTMPHKRNPIRSEKVSGLARVLYSNVIPALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKTTIKVLSGLEFFPENIKRNLYLTNNLIMAEPLMLKLTEKGMGRQEAHELVRQLAMKAFHEKRDLLEVVRESEEAMKYLTEEDLESLKPENYIGLAPQIVDNVIAFIGEKEREEAFMGR
The following text describes a protein:
Function:
A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are subsequently ligated to produce recombinant products. Cleaves both mobile and immobile junctions. Binds 4-way junction DNA, a synthetic Hj, binding is not competed by dsDNA.
Sequence:
MYRKGAQAERELIKLLEKHGFAVVRSAGSKKVDLVAGNGKKYLCIEVKVTKKDHLYVGKRDMGRLIEFSRRFGGIPVLAVKFLNVGWRFIEVSPKIEKFVFTPSSGVSLEVLLGIQKTLEGKS
The following text describes a protein:
Function:
General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
Subcellular Localization:
Nucleus.
Sequence:
MDDSVIYPQDLQYWRTLPAYAGLSKPPQADAATQTSPRHDGARTPPTGDVPDTWPATKPAPTVKRPPTSEVINDGVEARFSIGEDVFVTVGCFKGMPLVNVRRFYRPCPEKDVWKPGKQGLALAPEQWLALKRNMSSVSSALLACGFSAMHISYKYNGSTFPPSRFDLGNQRYAVVELFRGEAVVSLREFFRPKADEGKLLPSKKGLNLSTQQWDALEEQADKIDAVLKTVLEQKSLTSKVLKK
The following text describes a protein:
Function:
Involved in specific self-immunity to microcin C7.
Sequence:
MMIQSHPLLAAPLAVGDTIGFFSSSAPATVTAKNRFFRGVEFLQRKGFKLVSGKLTGKTDFYRSGTIKERAQEFNELVYNPDITCIMSTIGGDNSNSLLPFLDYDAIIANPKIIIGYSDTTALLAGIYAKTGLITFYGPALIPSFGEHPPLVDITYESFIKILTRKQSGIYTYTLPEKWSDESINWNENKILRPKKLYKNNCAFYGSGKVEGRVIGGNLNTLTGIWGSEWMPEILNGDILFIEDSRKSIATIERLFSMLKLNRVFDKVSAIILGKHELFDCAGSKRRPYEVLTEVLDGKQIPVLDGFDCSHTHPMLTLPLGVKLAIDFDNKNISITEQYLSTEK
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MPRKALLLKSLSRGKVRASFNKYNLFNLYKKSQIDLRTKTLYQQKWSSKQETRAYHGEHLTESRWQSTFSPRLTSVAQLDASLKGGDVAPTPILMQTYAVLEKRLEFALFRAMFASSVRQARQFILHGNVYVNGVTMKHPGYPLKAGDMFSVRPDKVLEALGARKPSLEQALAIDKQQIRMWNKYVTEARNNPREAWQGKIKQLQSMQASHPERQVFVELINHNNKQLDEKKLAVLKSTDKESLLCKVLAAAREHDGEKSISAATFRTASYGDAELAKALFEIYKTLEKSEALKILQDKTAEEQAKIILDSAAPEVSDAMKKKLRTTTSELGALMQQHDAAIRAFYDGKKGDPATLEMPYDSEWVESLRLHPQLKTKELLEDPAAAQKAVNLPWQKWPYGRQNPNKPYFTPWKPRPFLAPFAILPHHIEVSFKACHAIYLRDPVARPGHSEVISPFPLPVHERAYMYYLRKGQ
The following text describes a protein:
Function:
Required for normal rate of cell proliferation.
Miscellaneous:
MISCELLANEOUS: Present with 13100 molecules/cell in log phase SD medium.
Sequence:
MGLHSEPLDQEDQDTIILDARAGDLDSLKDIFTTLVSPELLSTCKESESDSTALHMAAANGHIETVRYILETVSRANSAEDLKAFVNEVNKTGNTALHWASLNGKLDVVKLLCDEYEADPFIRNKFGHDAIFEAENSGKEEVETYFLKKYDVEPEDDEEDTQTEGKNSVQITKGTEIEQVTKEATEALREETEKLNINKD
The following text describes a protein:
Function:
Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
Sequence:
MTPVISRVRIPPPAFRRDLKSSSNYNVSMSQPKRKEETVGVEMKGEEALAYVLNDIGLTKVFTTYSLPNIVKEMLKKYNIEVDFSISVKDASWLAYAYAMENNSVGTIIQIPGSKLTDAVDVIAQAYMESVPLLIISSVRSHKDTGRARIGEFRTIDDLSNILSPIIKTKERVISIEEITVTIEKAYKEAVSNRPRPSYVEISEDLFRAKAYPLSTAGQKPEKRTPDKNSVAKVAELLTNAKLPVIIAGYGVVLSDAEDMLVELAELIDSPVVTTFKAKGSIPSNHKLFAGEGLGAFSTSAANYLIENADVILALGTRFTQLSTAGWSLKYKGILVHNNVDGEDIGKVFMPHVPIVADTGLFLRELLTQLKAKIKEKINRGASDIIYKTQRQAYPITSHNDIWPIDVVKMLSSIGGFEKVYVDISATTIDLVRLPINAKKTWYTAESLLERGIAVGGIIASKYVAYGITDIEGILPHLSLLKYKMDKIKGKLIILNDGGANYIEVSNSDLPTIARSQTSFNANFDEIAEKALGGVTVNTLTELEEALKSVDKKIINVKIDPNFESVILSRI
The following text describes a protein:
Function:
Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart. Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein. In brain, involved in cognitive function, such as learning and long-term memory.
Sequence:
MKKTCGTLVVQTFLADLFRSAAEAGPHDILKLYSPKGSIINISTRLEPNSPSSCYRLEVVATDCSHQPPGAELAGGLDLSSIEKRSLQCLERNILIYDDKTPSVVFEMKKQVDSFREKLENVEHLSWLGLFKDLSEGTHKPSPFYHKRTLQKTREECERVREKFLQMSSLEVSEEVRNYLKTPTFDNWQWEDAEIMVLLQVMYTDLDFVASFNIEPETLQQFLFEVYRRYNNIPFHNFKHCFCVTQMMYGLIWLTDLRSKMDSINLLIMLTSAVCHDLDHTGYNNAYQINARTDLALRYNDISPLENHHCAVAFEILERSNIFRNLSPDQYKRIREGMIKCILATDMTRHNEILNKFKSTLPSFDFTNKEHKDLLMMILIKVSDISNEARPMEVAEPWLDCLLQEFFNQSDVEKLEGLPVTPFMDRDKVTKPSSQIGFIRFVLLPLLIELTKLFPCLKHHIIEPVRKALDYYTEMEKALEKEQQAWAQSENVAKSNEEDDGQDNPNSNLLSVVLQLNSASQVSRCIKNPKDSLLLHLYRCNNLGKIKTQIKGN
The following text describes a protein:
Function:
Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.
Sequence:
MYSLIISDILSTFTSVEHCFILGDVTYGACCVDDLSAAALSADLLIHFGHSCLVPIDSTTIPCLYIFVEISIDVHRLLNELKLNFCNSRIYDNIVMAGTIQFATAIRAVKPELEKLGFSVLVPQAKPLSAGEVLGCTAPSVRNRIADGEDVVLVFVADGRFHLEAFMIANPGIKTYRYDPFIGKLFVEEYDHKGMKEERKRAIEKAREAKNWGIVLGTLGRQGNPRILDRLEKKMAEKGMTWTVVLMSEISPTRIALFEDAVDAWIQIACPRLSIDWGDAFKRPLLTPFEAEIALGELSGWWERKTVVNSDECCDEGVKCSKNESCGACDNGGEEVKERVPVDYPMDYYAQDGGEWNSCYSKKPARLSQRSSQSCNGNSAIKCSNC
The following text describes a protein:
Function:
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MIPGTETIRNVIADLRIAASFVTLLPVGSSKPAADGAIARATWALPVAGLLVGLAGALVYKISSRLGLTPNLAALLALATTALITGALHEDGLADTADGLGGGRTRERKLEIMRDSRIGTYGVCALILSFGLRWSALAAIANPWLVTLALCAAHCAARAGVPAFMSLVPPARPDGLSASAGAPPGRSVAIAFAVGTLVLTLALGPGKALVGLILLSLAGLILARLAIRQIGGQTGDILGAFEQTGEIVILLVAAAFQMGR
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MFSRLSLFRRAALAPAPMRMSFRTIYQKTEDELPRRIVPKLATFYSANPNHEDRINRLERLLRKYIKLPSQNNNEAQQTKAPWISFDEYALIGGGTKLKPTQYTQLLYMLNKLHNIDPQLTNDEITSELSQYYKKSSMLSNNIKIKTLDEFGRSIAVGKRKSSTAKVFVVRGTGEILVNGRQLNDYFLKMKDRESIMYPLQVIESVGKYNIFATTSGGGPTGQAESIMHAIAKALVVFNPLLKSRLHKAGVLTRDYRHVERKKPGKKKARKMPTWVKR
The following text describes a protein:
Function:
Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity).
Subcellular Localization:
Cytoplasm. Preautophagosomal structure.
Sequence:
MSFQGTSSGSSHSSKSKLNQVVQNFFSKATQVVVQARLNPRLREQRQSGDKHKLNKWFNLETDELEAYREDLKLWRTIDIYNMDKMPPVVVETYLDMRHLSPNQTLVLEDAFGKRWNASFGGRKTEVVLERWVIEIQRPDPQAGGATTSPASSTELPMAYKKCILLFRSLYTYCRLLPAWTLQKRLSKSKLSTSPLRIGCRVLNGSQPISSRGRVGLSKLIAGSSESQHLQTFSFDPVEIPSGVFKISVSYRVNCNFAVDDSEAMLSSQFLRIDEEKPVVPPSPPVKHPSMAAPNLHYITGLPRRHSHSQGVGVSGAAIVPTSVSSVTDYMERRRSSGASGVGATGGGLAGTSGGSGGVSGGVSGGSGGSGGSGGWGGEEGSPGPAATSASPSTPPFARVPSSSSLAALRIPRRTISNSSTSSTNNARVVTTPGYTPSAYEQAISSSGGSSRSGSVPKYSSSFGTRQWNRSGSISSTRRRNSMLVGSAESAMSSGSSLMEPGSGFIDIEDPTDVSDFVKMVDSIKPGSPYSLPSPRKGSDPLARFQQLKGSHAGIADSITSSIYHHQPSPPYVRSKLSGEANLEAISSLPRPVTVPPSPRKLETQMQPISLADQHTSEYHQLQQRTSARPQAHSYSERDQLDNSHYKALERYDLVGASPSVVGSRYYTEHDRGRGEKRYSVAPLPGLEFDEDDDLLFAMSDMAMGDSASGGNVRT
The following text describes a protein:
Function:
Probably involved in reactive chlorine species (RCS) stress resistance.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MEKYLHLLSRGDKIGLTLIRLSIAIVFMWIGLLKFVPYEADSITPFVANSPLMSFFYEHPEDYKQYLTHEGEYKPEARAWQTANNTYGFSNGLGVVEVIIALLVLANPVNRWLGLLGGLMAFTTPLVTLSFLITTPEAWVPALGDAHHGFPYLSGAGRLVLKDTLMLAGAVMIMADSAREILKQRSNESSSTLKTEY
The following text describes a protein:
Function:
Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP) (Probable). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales. To a much lesser extent, is also able to use geranylgeranyl diphosphate (GGPP; C20) as the prenyl donor.
Sequence:
MYDISGWKHVFKLDPNKELSDEHLEMICESGTDAVIVGGSDGVTIDNVLHMLVSIRRYAVPCVLEVSDVEAITPGFDFYYIPSVLNSRKVEWVTGVHHEALKEFGDIMDWDEIFMEGYCVLNPEAKVAQLTDAKCDVTEDDVIAYARLADKLLRLPIFYLEYSGTYGDVELVKNVKAELKQAKLYYGGGISNAEQAKEMAQHADTVVVGNIIYDDIKAALKTVKAVKGE
The following text describes a protein:
Function:
Core component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The classical complement pathway is initiated by the C1Q subcomplex of the C1 complex, which specifically binds IgG or IgM immunoglobulins complexed with antigens, forming antigen-antibody complexes on the surface of pathogens: C1QA, together with C1QB and C1QC, specifically recognizes and binds the Fc regions of IgG or IgM via its C1q domain. Immunoglobulin-binding activates the proenzyme C1R, which cleaves C1S, initiating the proteolytic cascade of the complement system. The C1Q subcomplex is activated by a hexamer of IgG complexed with antigens, while it is activated by a pentameric IgM. The C1Q subcomplex also recognizes and binds phosphatidylserine exposed on the surface of cells undergoing programmed cell death, possibly promoting activation of the complement system.
Subcellular Localization:
Secreted. Cell surface. Note=Specifically binds IgG or IgM immunoglobulins complexed with antigens, forming antigen-antibody complexes on the surface of pathogens.
Domain:
The C1q domain is the ligand-recognition domain, which specifically recognizes and binds the Fc regions of IgG or IgM immunoglobulins; The collagen-like domain interacts with C1R and C1S proenzymes.
Sequence:
MVVGPSCQPPCGLCLLLLFLLALPLRSQASAGCYGIPGMPGMPGAPGKDGHDGLQGPKGEPGIPAVPGTRGPKGQKGEPGMPGHRGKNGPRGTSGLPGDPGPRGPPGEPGVEGRYKQKHQSVFTVTRQTTQYPEANALVRFNSVVTNPQGHYNPSTGKFTCEVPGLYYFVYYTSHTANLCVHLNLNLARVASFCDHMFNSKQVSSGGVLLRLQRGDEVWLSVNDYNGMVGIEGSNSVFSGFLLFPD