Dyskusja:Ayahuasca

message: Uważam, że hasło jest skrajnie (skandalicznie) nieobiektywne i przez pominięcie aspektów farmakologicznych, zakrawa na propagowanie narkotyku (składowe a. zostały we Francji, jako narkotyki zakazane - p. niżej). Hasło trzeba usunąć, albo b. rozbudować. Poniżej daję to, o co mi chodzi (z anglojęzycznej Wikipedii). Pozdrawiam Joanna Wieczorek (dyskusja) 20:18, 25 mar 2017 (CET)
Chemistry and pharmacology 
Harmala alkaloids are MAO-inhibiting beta-carbolines. The three most studied harmala alkaloids in the B. caapi vine are harmine, harmaline and tetrahydroharmine. Harmine and harmaline are selective and reversible inhibitors of monoamine oxidase A (MAO-A), while tetrahydroharmine is a weak serotonin reuptake inhibitor (SRI).
This inhibition of MAO-A allows DMT to diffuse unmetabolized past the membranes in the stomach and small intestine, and eventually cross the blood–brain barrier (which, by itself, requires no MAO-A inhibition) to activate receptor sites in the brain. Without RIMAs or the MAOI of MAO-A, DMT would be oxidised (and thus rendered biologically inactive) by monoamine oxidase enzymes in the digestive tract.
Individual polymorphisms in the cytochrome P450-2D6 enzyme affect the ability of individuals to metabolize harmine. Some natural tolerance to habitual use of ayahuasca (roughly once weekly) may develop through upregulation of the serotonergic system. A phase 1 pharmacokinetic study on ayahuasca (as Hoasca) with 15 volunteers was conducted in 1993, during the Hoasca Project. A review of the Hoasca Project has been published.
Effects
People who have consumed ayahuasca report having spiritual revelations regarding their purpose on earth, the true nature of the universe as well as deep insight into how to be the best person they possibly can. This is viewed by many as a spiritual awakening and what is often described as a rebirth. In addition, it is often reported that individuals feel they gain access to higher spiritual dimensions and make contact with various spiritual or extra-dimensional beings who can act as guides or healers.
Author Don Jose Campos claims that people may experience profound positive life changes subsequent to consuming ayahuasca. Vomiting can follow ayahuasca ingestion; this purging is considered by many shamans and experienced users of ayahuasca to be an essential part of the experience, as it represents the release of negative energy and emotions built up over the course of one's life. Others report purging in the form of nausea, diarrhea, and hot/cold flashes.
The ingestion of ayahuasca can also cause significant, but temporary, emotional and psychological distress. Excessive use can lead to serotonin syndrome, with symptoms such as tremors, diarrhea, autonomic instability, hyperthermia, sweating, muscle spasms and possible death. Long-term negative effects are not known. A few deaths due to participation in the consumption of ayahuasca have been reported. Some of the deaths may have been due to unscreened preexisting heart conditions, interaction with drugs, such as antidepressants, recreational drugs, caffeine, or nicotine, or any of the various additional plants that are frequently added to brews.
Research developed by the Beckley Foundation suggests ayahuasca intake can led to significant increases in mindfulness abilities and that ayahuasca can promote neurogenesis (the growth of new brain cells) in vitro. Tim Ferriss said he found a two-day use of ayahuasca removed 90% of his long-standing anger issues.
Legal status
[...] In France, Santo Daime won a court case allowing them to use the tea in early 2005; however, they were not allowed an exception for religious purposes, but rather for the simple reason that they did not perform chemical extractions to end up with pure DMT and harmala and the plants used were not scheduled.[56] Four months after the court victory, the common ingredients of ayahuasca as well as harmala were declared stupéfiants, or narcotic schedule I substances, making the tea and its ingredients illegal to use or possess.
* W Wikipedii trzymamy się zasady Wikipedia:Śmiało modyfikuj strony, zatem lepiej poprawić i uzupełnić encyklopedyczne hasło informacjami mającymi poparcie w źródłach (również wtedy należy je podać, gdy informacje są tłumaczeniem z np. en.Wiki!), niż kasować. Ented (dyskusja) 20:24, 25 mar 2017 (CET)
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