Query: In practice, Pre-Columbian refers to the history of the indigenous cultures of America prior to Europeans doing what to them?
Context: While technically referring to the era before Christopher Columbus' voyages of 1492 to 1504, in practice the term usually includes the history of American indigenous cultures until Europeans either conquered or significantly influenced them, even if this happened decades or even centuries after Columbus' initial landing. "Pre-Columbian" is used especially often in the context of discussing the great indigenous civilizations of the Americas, such as those of Mesoamerica (the Olmec, the Toltec, the Teotihuacano, the Zapotec, the Mixtec, the Aztec, and the Maya civilizations) and those of the Andes (Inca Empire, Moche culture, Muisca Confederation, Cañaris).