Query: Do 1,25(OH)2D3-gly and/or 1,25(OH)2D3 accumulate in the body?
Context: No, they do not. 1,25(OH)2D3-gly is not absorbed from the intestinal tract because it is water-soluble, so any excess of 1,25(OH)2D3-gly passes through the gastrointestinal tract and is not accumulated in the body. In addition, free 1,25(OH)2D3 is rapidly degraded once it has fulfilled its task.