page_title: Polioencephalomalacia
hierarchical_section_title: Polioencephalomalacia
caption_attribution_description: Walon: Moraedje gris do cervea a ene berbis coûtchêye sol flanc, tiesse sorsitindowe; li biesse va rweri après médiaedje al vitamene B1 (loukîz cial). English: ewe with encephalomalacia lateral recumbency and opisthotonus; this ewe will recover after Vitamin B1 treatment (on this file)
context_page_description: Polioencephalomalacia, also referred to as cerebrocortical necrosis, is a neurological disease seen in ruminants that is caused by multiple factors, one of which is thiamine depletion in the body. Thiamine is a key chemical in glucose metabolism that, when deficient, is most threatening to neurological activity. In addition to altered thiamine status, an association with high sulfur intake has been observed as a potential cause of PEM. Other toxic or metabolic diseases can result in PEM as well. Cattle, sheep, goat, and other ruminants that are diagnosed with PEM or pre-PEM suffer opisthotonus, cortical blindness, disoriented movement, and eventually fatality, if left untreated. Current data shows that the onset of PEM can range from birth to late adulthood.
context_section_description: Polioencephalomalacia (PEM), also referred to as cerebrocortical necrosis (CCN), is a neurological disease seen in ruminants that is caused by multiple factors, one of which is thiamine depletion in the body. Thiamine is a key chemical in glucose metabolism that, when deficient, is most threatening to neurological activity. In addition to altered thiamine status, an association with high sulfur intake has been observed as a potential cause of PEM. Other toxic or metabolic diseases (eg, acute lead poisoning, sodium toxicosis/water deprivation) can result in PEM as well. Cattle, sheep, goat, and other ruminants that are diagnosed with PEM or pre-PEM suffer opisthotonus, cortical blindness, disoriented movement, and eventually fatality, if left untreated. Current data shows that the onset of PEM can range from birth to late adulthood.
caption: lateral recumbency and opisthotonos
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