page_title: Ornithine transcarbamylase
section_title: Active site
hierarchical_section_title: Ornithine transcarbamylase / Structure / Active site
caption_attribution_description: English: Binding Site of Carbamoly Phosphate in Ornithine Transcarbamylase. Carbamoyl Phosphate is shown.
context_page_description: Ornithine transcarbamylase is an enzyme that catalyzes the reaction between carbamoyl phosphate and ornithine to form citrulline and phosphate. There are two classes of OTC anabolic and catabolic. Anabolic OTC facilitates the sixth step in the biosynthesis of the amino acid arginine in prokaryotes. In contrast, mammalian OTC plays an essential role in the urea cycle whose purpose is to capture toxic ammonia and transform it into less toxic urea nitrogen source for excretion.
context_section_description: Ser-Thr-Arg-Thr-Arg motif from one subunit and a His from the neighboring subunit both interact with the phosphate group of CP for binding. Binding the primary nitrogen of CP are residues Gln, Cys, and Arg. The carbonyl oxygen of CP is bound by residues Thr, Arg, and His.
caption: Depicted is CP situated in OTC's Binding Site with residues that play an important role in binding CP.[9]
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