page_title: Thymidylate kinase
hierarchical_section_title: Thymidylate kinase
caption_attribution_description: English: Thymidylate kinase dimer + 2 ADP (green) + 2 TMP (l.blue) + 5 Mg (red), Human
context_page_description: Thymidylate kinase catalyzes the phosphorylation of thymidine 5'-monophosphate to form thymidine 5'-diphosphate in the presence of ATP and magnesium:
  ATP + thymidine 5'-phosphate ADP + thymidine 5'-diphosphate
  Thymidylate kinase is a ubiquitous enzyme of about 25 Kd and is important in the dTTP synthesis pathway for DNA synthesis. The function of dTMP kinase in eukaryotes comes from the study of a cell cycle mutant, cdc8, in Saccharomyces cerevisiae. Structural and functional analyses suggest that the cDNA codes for authentic human dTMP kinase. The mRNA levels and enzyme activities corresponded to cell cycle progression and cell growth stages.
  Thymidylate kinase's subfamily is predicted thymidylate kinase, TKRP1. InterPro: IPR014505
  Human protein DTYMK contains this domain.
context_section_description: Thymidylate kinase (EC 2.7.4.9; dTMP kinase) catalyzes the phosphorylation of thymidine 5'-monophosphate (dTMP) to form thymidine 5'-diphosphate (dTDP) in the presence of ATP and magnesium:
  ATP + thymidine 5'-phosphate  ADP + thymidine 5'-diphosphate
  Thymidylate kinase is a ubiquitous enzyme of about 25 Kd and is important in the dTTP synthesis pathway for DNA synthesis. The function of dTMP kinase in eukaryotes comes from the study of a cell cycle mutant, cdc8, in Saccharomyces cerevisiae. Structural and functional analyses suggest that the cDNA codes for authentic human dTMP kinase. The mRNA levels and enzyme activities corresponded to cell cycle progression and cell growth stages.
  Thymidylate kinase's subfamily is predicted thymidylate kinase, TKRP1. InterPro: IPR014505
  Human protein DTYMK contains this domain.
caption: Thymidylate kinase dimer, Human
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