page_title: HIKESHI
section_title: Evolutionary History
hierarchical_section_title: HIKESHI / Evolutionary History
caption_attribution_description: English: Evolutionary History of C11orf73
context_page_description: HIKESHI is a protein important in lung and multicellular organismal development that, in humans, is encoded by the HIKESHI gene. HIKESHI is found on chromosome 11 in humans and chromosome 7 in mice. Similar sequences are found in most animal and fungal species. The mouse homolog, lethal gene on chromosome 7 Rinchik 6 protein is encoded by the l7Rn6 gene. When the l7Rn6 protein is disrupted in mice, the mice display severe emphysema at birth as a result of disorganization of the Golgi apparatus and formation of aberrant vesicular structures within club cells.
context_section_description: The evolutionary history of organisms can be determined using the sequences of orthologs as time references to create a phylogenetic tree. The CLUSTALW compares multiple sequences, the program can also be used to create such a phylogenetic tree based on the orthologs of C11orf73. The tree to the right shows the generated phylogenetic tree with a time line based on time of divergence. The tree made from the HIKESHI orthologs is identical to the literature phylogenetic tree, even grouping together similar organisms such as fish, birds, and fungi.
caption: Phylogenetic tree of C11orf73.
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