page_title: Durotaxis
section_title: Atherosclerosis
hierarchical_section_title: Durotaxis / Clinical significance / Atherosclerosis
caption_attribution_description: LDL'nin damar intima matrisinde oksitlenmesi (oxLDL) aterom oluşumunun ilk adımıdır. Endotel hürlerinin oxLDL tarafından uyarılması kandaki monositelerin seferber olup damar duvarına girmesine neden olur. Monositlerin makrofajlara dönüşümü ve kümelenmiş oxLDL'nin Avcı Reseptör (Scavenger receptor') tarafından bu hücrelerin içine alınması sonucu köpük hücreler meydana gelir. Damar düz kas hücrelerinin uyarılmısı bunların harekete geçmelerine ve çoğalmalarına neden olur. Doku Faktörü (Tissue Factor, TF), düz kas hücreleri ve makrofajların yüzeyünde belirir ve birikmiş fibrin'in fibrinojene dönüşmesine neden olur. en: The initiation of an atherosclerotic lesion is characterized by retention of LDL and subsequent oxidative modification (oxLDL) within the matrix of the vascular intima Figure 1 from "Blood coagulation and the risk of atherothrombosis: a complex relationship" Henri MH Spronk , Danielle van der Voort and Hugo ten Cate (2004) Thrombosis Journal 2004, 2:12 doi:10.1186/1477-9560-2-12 [1] tr: LDL'nin damar intima matrisinde alıkonup orada oksidatif değişime uğraması aterosklerotik lezyonu başlatır. "Blood coagulation and the risk of atherothrombosis: a complex relationship" Henri MH Spronk , Danielle van der Voort and Hugo ten Cate (2004) Thrombosis Journal 2004, 2:12 doi:10.1186/1477-9560-2-12 [2] makalesinde Resim 1.
context_page_description: Durotaxis is a form of cell migration in which cells are guided by rigidity gradients, which arise from differential structural properties of the extracellular matrix. Most normal cells migrate up rigidity gradients.
context_section_description: The pathology of atherosclerosis is largely dependent on the migration of vascular smooth muscle cells (VSMCs) into the tunica intima layer of the blood vessel, where they can accumulate lipids, undergo necrosis, and elaborate the ECM (fibrosis). The migration of these cells has also been demonstrated to be rigidity-dependent, and matrix stiffness further affects their proliferation in response to growth factors.
caption: A diagram of the formation of an atherosclerotic plaque. Note the blue vascular smooth muscle cells, which migrate from the tunica media into the tunica intima, where the stiff plaque is forming.
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