page_title: EML4-ALK positive lung cancer
section_title: Screening
hierarchical_section_title: EML4-ALK positive lung cancer / Screening
caption_attribution_description: English: Micrograph showing ALK positive adenocarcinoma of the lung. H&amp;E stain/ALK immunostain. Related images ALK +ve lung adenoca - very low mag. ALK +ve lung adenoca - low mag. ALK +ve lung adenoca - intermed. mag. ALK +ve lung adenoca - high mag. ALK +ve lung adenoca - high mag. ALK +ve lung adenoca - very high mag. ALK +ve lung adenoca - very low mag. ALK +ve lung adenoca - low mag. ALK +ve lung adenoca - intermed. mag. ALK +ve lung adenoca - high mag. ALK +ve lung adenoca - high mag. ALK +ve lung adenoca - very high mag. ALK +ve lung adenoca - very high mag.
context_page_description: EML4-ALK positive lung cancer is a primary malignant lung tumor whose cells contain a characteristic abnormal configuration of DNA wherein the echinoderm microtubule-associated protein-like 4 gene is fused to the anaplastic lymphoma kinase gene. This abnormal gene fusion leads to the production of a protein that appears, in many cases, to promote and maintain the malignant behavior of the cancer cells.
  The transforming EML4-ALK fusion gene was first reported in non-small cell lung carcinoma in 2007.
context_section_description: Screening for ALK positive lung cancer is now a standard of care in the United States and Canada.  Screening can be done with immunostaining, FISH, or next-generation sequencing (NGS).
caption: Micrograph showing an ALK positive adenocarcinoma of the lung. ALK immunostain.
exif: {"Image Make": "Canon", "Image Model": "Canon EOS Rebel T6s", "Image Orientation": "Horizontal (normal)", "Image XResolution": "72", "Image YResolution": "72", "Image ResolutionUnit": "Pixels/Inch", "Image DateTime": "2018:09:05 21:12:40", "Image Artist": "", "Image YCbCrPositioning": "Co-sited", "Image Copyright": "", "Image ExifOffset": "220", "GPS GPSVersionID": "[2, 3, 0, 0]", "Image GPSInfo": "9622", "Thumbnail Compression": "JPEG (old-style)", "Thumbnail XResolution": "72", "Thumbnail YResolution": "72", "Thumbnail ResolutionUnit": "Pixels/Inch", "Thumbnail JPEGInterchangeFormat": "9734", "Thumbnail JPEGInterchangeFormatLength": "9995", "EXIF ExposureTime": "1/50", "EXIF FNumber": "0", "EXIF ExposureProgram": "Aperture Priority", "EXIF ISOSpeedRatings": "6400", "EXIF ExifVersion": "0230", "EXIF DateTimeOriginal": "2018:08:16 16:40:40", "EXIF DateTimeDigitized": "2018:08:16 16:40:40", "EXIF ComponentsConfiguration": "YCbCr", "EXIF ShutterSpeedValue": "45/8", "EXIF ApertureValue": "2147483648", "EXIF ExposureBiasValue": "0", "EXIF MeteringMode": "Pattern", "EXIF Flash": "Flash did not fire, compulsory flash mode", "EXIF FocalLength": "0", "EXIF SubSecTime": "38", "EXIF SubSecTimeOriginal": "38", "EXIF SubSecTimeDigitized": "38", "EXIF FlashPixVersion": "0100", "EXIF ColorSpace": "sRGB", "EXIF ExifImageWidth": "4000", "EXIF ExifImageLength": "6000", "Interoperability InteroperabilityIndex": "R98", "Interoperability InteroperabilityVersion": "[48, 49, 48, 48]", "EXIF InteroperabilityOffset": "9592", "EXIF FocalPlaneXResolution": "6000000/893", "EXIF FocalPlaneYResolution": "2000000/297", "EXIF FocalPlaneResolutionUnit": "2", "EXIF CustomRendered": "Normal", "EXIF ExposureMode": "Auto Exposure", "EXIF WhiteBalance": "Auto", "EXIF SceneCaptureType": "Standard"}