page_title: Uroporphyrinogen-III C-methyltransferase
hierarchical_section_title: Uroporphyrinogen-III C-methyltransferase
caption_attribution_description: English: structure of dihydrosirochlorin
context_page_description: Uroporphyrinogen-III C-methyltransferase, uroporphyrinogen methyltransferase, uroporphyrinogen-III methyltransferase, adenosylmethionine-uroporphyrinogen III methyltransferase, S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase, uroporphyrinogen-III methylase, SirA, CysG, CobA, uroporphyrin-III C-methyltransferase, S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase is an enzyme with systematic name S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase. This enzyme catalyses the following chemical reaction
  2 S-adenosyl-L-methionine + uroporphyrinogen III 2 S-adenosyl-L-homocysteine + precorrin-2
  S-adenosyl-L-methionine + uroporphyrinogen III S-adenosyl-L-homocysteine + precorrin-1
  S-adenosyl-L-methionine + precorrin-1 S-adenosyl-L-homocysteine + precorrin-2
  Uroporphyrinogen-III C-methyltransferase catalyses two methylation reactions. The first reaction converts uroporphyrinogen III into precorrin-1. The second converts precorrin-1 into precorrin-2. These reactions are part of the biosynthetic pathway to cobalamin in both anaerobic and aerobic bacteria.
context_section_description: Uroporphyrinogen-III C-methyltransferase (EC 2.1.1.107), uroporphyrinogen methyltransferase, uroporphyrinogen-III methyltransferase, adenosylmethionine-uroporphyrinogen III methyltransferase, S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase, uroporphyrinogen-III methylase, SirA, CysG, CobA, uroporphyrin-III C-methyltransferase, S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase. This enzyme catalyses the following chemical reaction
  2 S-adenosyl-L-methionine + uroporphyrinogen III  2 S-adenosyl-L-homocysteine + precorrin-2 (overall reaction)
  (1a) S-adenosyl-L-methionine + uroporphyrinogen III  S-adenosyl-L-homocysteine + precorrin-1
  (1b) S-adenosyl-L-methionine + precorrin-1  S-adenosyl-L-homocysteine + precorrin-2
  Uroporphyrinogen-III C-methyltransferase catalyses two methylation reactions.  The first reaction converts uroporphyrinogen III into precorrin-1.  The second converts precorrin-1 into precorrin-2. These reactions are part of the biosynthetic pathway to cobalamin (vitamin B₁₂) in both anaerobic and aerobic bacteria.
caption: precorrin-2 product of the enzyme
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