page_title: Mesenchymal–epithelial transition
section_title: In development
hierarchical_section_title: Mesenchymal–epithelial transition / In development
caption_attribution_description: English: The role of EMT and MET in malignancy, with key biological features and EMT-inducers highlighted. EMT: epithelial-mesenchymal transition; MET: mesenchymal-epithelial transition from [The importance of epithelial-mesenchymal transition and autophagy in cancer drug resistance/Charlotte Hill and Yihua Wang/Cancer Drug Resist 2020;3/mesenchymal-epithelial transition]
context_page_description: A mesenchymal–epithelial transition is a reversible biological process that involves the transition from motile, multipolar or spindle-shaped mesenchymal cells to planar arrays of polarized cells called epithelia. MET is the reverse process of epithelial–mesenchymal transition and it has been shown to occur in normal development, induced pluripotent stem cell reprogramming, cancer metastasis and wound healing.
context_section_description: During embryogenesis and early development, cells switch back and forth between different cellular phenotypes via MET and its reverse process, epithelial–mesenchymal transition (EMT).  Developmental METs have been studied most extensively in embryogenesis during somitogenesis and nephrogenesis and carcinogenesis during metastasis, but it also occurs in cardiogenesis or foregut development.  MET is an essential process in embryogenesis to gather mesenchymal-like cells into cohesive structures. Although the mechanism of MET during various organs morphogenesis is quite similar, each process has a unique signaling pathway to induce changes in gene expression profiles.
caption: EMT: epithelial-mesenchymal transition; MET: mesenchymal-epithelial transition
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