page_title: Vacuolization
hierarchical_section_title: Vacuolization
caption_attribution_description: English: Micrograph of perinuclear vacuolization (one indicated by arrows), as an incidental finding in a skin slice taken at the edge of a skin excision with basal-cell carcinoma, with no signs of non-radical excision.
context_page_description: Vacuolization is the formation of vacuoles or vacuole-like structures, within or adjacent to cells. Perinuclear vacuolization of epidermal keratinocytes is most likely insignificant when not seen in combination with other pathologic findings. In dermatopathology "vacuolization" often refers specifically to vacuoles in the basal cell-basement membrane zone area, where it is an unspecific sign of disease. It may be a sign of for example vacuolar interface dermatitis, which in turn has many causes.
  It is one of the components of koilocytosis, which may be present in potentially precancerous cervical, oral and anal lesions.
context_section_description: Vacuolization is the formation of vacuoles or vacuole-like structures, within or adjacent to cells. Perinuclear vacuolization of epidermal keratinocytes is most likely insignificant when not seen in combination with other pathologic findings. In dermatopathology "vacuolization" often refers specifically to vacuoles in the basal cell-basement membrane zone area, where it is an unspecific sign of disease. It may be a sign of for example vacuolar interface dermatitis, which in turn has many causes.
  It is one of the components of koilocytosis, which may be present in potentially precancerous cervical, oral and anal lesions.
caption: Perinuclear vacuolization of epidermal keratinocytes (one indicated by arrows), in this case an insignificant incidental finding.
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