page_title: De-linkage
section_title: De-linkage and development of new antibiotics
hierarchical_section_title: De-linkage / De-linkage and development of new antibiotics
caption_attribution_description: English: Antibiotic resistance tests; the bacteria in the culture on the left are sensitive to the antibiotics contained in the white paper discs. The bacteria on the right are resistant to most of the antibiotics Français&#160;: Tests de résistance aux antibiotiques&#160;: Une souche bactérienne a été introduite et cultivée dans un milieu de culture dans une boite de pétri. Puis des disques blancs contenant chacun un antibiotique différent ont été introduits dans la boite. Les bactéries de la culture de gauche sont sensibles à tous les antibiotique testés (comme le montrent les anneaux) alors que dans la boite de droite, elles ne sont sensibles qu'à seulement trois des sept antibiotiques testés Deutsch: Antibiotika-Resistenz-Tests: Ein Bakterienstamm wurde in einem Kulturmedium in einer Petrischale eingebracht und aufgewachsen . Dann weiß Scheiben jeweils einen anderen Antibiotikum enthalten, wurden in die Box eingeführt. Die Bakterienkultur links zu allen getesteten Antibiotika empfindlich sind, während in der Box auf der rechten Seite (wie durch die Ringe gezeigt), sind sie nur empfindlich gegenüber nur drei der sieben getesteten Antibiotika Nederlands: Antibioticaresistentie testen: Een bacteriële stam werd geïntroduceerd en gekweekt in een kweekmedium in een petrischaal. Dan witte schijven die elk een ander antibioticum zijn geïntroduceerd in de doos. De bacteriekweek linker gevoelig voor alle geteste (zoals getoond door de ringen), terwijl in de doos op de juiste antibiotica, ze alleen gevoelig zijn slechts drie van de zeven geteste antibiotica Español: Pruebas de resistencia a los antibióticos&#160;: Una cepa bacteriana se introdujo y se cultiva en un medio de cultivo en una placa de Petri. A continuación, los discos blancos que contienen cada uno un antibiótico diferente se han introducido en la caja. La izquierda cultivo de bacterias son sensibles a todos los antibióticos probados (como se muestra por los anillos), mientras que en el cuadro de la derecha, que sólo son sensibles a sólo tres de los siete antibióticos probados
context_page_description: De-linkage is a proposed model for development of new pharmaceutical drugs where "de-link" refers to isolating the profitability of a drug from its volume of sales.
  In the current business model, the pharmaceutical industry relies on the pricing and sales of its products to generate profits and to finance research and development of new drugs. This ability is dependent on the monopoly granted through patents.
  In the de-linkage model, other means would be used to reward companies for research and development in exchange for restricting the price charged for the product. This would allow the product to be sold at prices closer to production costs which would ensure better access, particularly for poor people and those who pay for their own treatment.
context_section_description: Until resistance has emerged against a previous generation of antibiotic, commercial return for any given new drug is uncertain. Therefore, the de-linkage model may be preferable in the context of developing new antibiotics and the fight against resistance where new antibiotics initially are unlikely to sell in large quantities because they should be reserved for use only when all other options have been exhausted. De-linkage also removes the incentive for the industry to boost sales that may encourage overuse that accelerate the development of antibiotic resistance.
caption: Antibiotic resistance tests
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