page_title: Early 35 kDa protein
hierarchical_section_title: Early 35 kDa protein
caption_attribution_description: English: Structure of the baculoviral protein P35
context_page_description: The Early 35 kDa protein, or P35 in short, is a baculoviral protein that inhibits apoptosis in the cells infected by the virus. Although baculoviruses infect only invertebrates in nature, ectopic expression of P35 in vertebrate animals and cells also results in inhibition of apoptosis, thus indicating a universal mechanism. P35 has been shown to be a caspase inhibitor with a very wide spectrum of activity both in regard to inhibited caspase types and to species in which the mechanism is conserved.
context_section_description: The Early 35 kDa protein, or P35 in short, is a baculoviral protein that inhibits apoptosis in the cells infected by the virus. Although baculoviruses infect only invertebrates in nature, ectopic expression of P35 in vertebrate animals and cells also results in inhibition of apoptosis, thus indicating a universal mechanism. P35 has been shown to be a caspase inhibitor with a very wide spectrum of activity both in regard to inhibited caspase types and to species in which the mechanism is conserved.
caption: P35 structure by Fisher et al. 1999[1]
exif: {"Image ExifOffset": "28", "EXIF ImageDescription": "ImageSource=RCSB PDB; StructureID=1p35; DOI=http://dx.doi.org/10.2210/pdb1p35/pdb;"}