page_title: Aggressive lymphoma
section_title: Diffuse large B-cell Lymphoma (DLBCL)
hierarchical_section_title: Aggressive lymphoma / Types / Diffuse large B-cell Lymphoma (DLBCL)
caption_attribution_description: Burkitt lymphoma, touch prep, Wright stain
context_page_description: Aggressive lymphoma also known as high-grade lymphoma is a group of fast growing Non-Hodgkin Lymphoma.
  Some common symptoms for aggressive lymphoma are weight loss, night sweats, nausea and recurrent fevers. Since these tumors are fast to grow and spread, immediate intervention is required after diagnosis.
  There are several subtypes of aggressive lymphoma. These include AIDS-associated lymphoma, angioimmunoblastic lymphoma, Burkitt lymphoma, central nervous system lymphoma, diffuse large B-cell lymphoma, mantle cell lymphoma and peripheral T-cell lymphoma. Diffuse large B-cell lymphoma is the most common subtype as well as the most common type of Non-Hodgkin Lymphoma.
  Aggressive lymphoma accounts for approximately 60 percent of all Non-Hodgkin Lymphoma cases in the United States.
context_section_description: Diffuse large B cell lymphoma (DLBCL) is a type of high-grade NHL which is the most common type of NHL worldwide at affecting 30-40 percent of all NHL cases. It is more prevalent in elderly patients with a median age of 70 years. Patients most often present with a rapidly growing tumor mass in single or multiple, nodal or extranodal sites. The most commonly diagnosed versions of DLBCL are germinal center B-cell like (GCB) and activated B-cell like (ABC) subtypes.
  Immunohistochemical and flow cytometry analysis is also necessary for the diagnosis of this disease. The DLBCL cells have found to express B-cell antigens such as CD19, CD20, and CD22 as well as the transcription factors PAX5, BOB.1, and OCT2. CD20 is especially relevant in diagnostics as well as therapeutics because it is the target of the Rituximab humanized monoclonal antibody that is used in the most common treatment strategy. In addition to this, the majority of cells also express surface or cytoplasmic immunoglobulins, specifically IgM, IgG and IgA. While these analyses allow for diagnosis by displaying proof of B-cell lineage, they can also be used in treatment strategy and can give insight into prognosis of the specific case being considered.
caption: Burkitt Lymphoma
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