page_title: Nitrile hydratase
section_title: Structure
hierarchical_section_title: Nitrile hydratase / Structure
caption_attribution_description: English: Cartoon representation of the molecular structure of protein registered with 2ahj code. Deutsch: Grafik des Molekularstruktur von jenem Protein, das mit 2ahj code registriert ist. Plattdüütsch: Grafik, de de Molekularstruktur von dat Protein wiest, dat mit’n Kood 2ahj registreert is.
context_page_description: In enzymology, nitrile hydratases are mononuclear iron or non-corrinoid cobalt enzymes that catalyse the hydration of diverse nitriles to their corresponding amides
context_section_description: NHases are composed of two types of subunits, α and β, which are not related in amino acid sequence. NHases exist as αβ dimers or α₂β₂ tetramers and bind one metal atom per αβ unit. The 3-D structures of a number of NHases have been determined. The α subunit consists of a long extended N-terminal "arm", containing two α-helices, and a C-terminal domain with an unusual four-layered structure (α-β-β-α). The β subunit consists of a long N-terminal loop that wraps around the α subunit, a helical domain that packs with N-terminal domain of the α subunit, and a C-terminal domain consisting of a β-roll and one short helix.
caption: Structure of nitrile hydratase.[7]
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