page_title: Cuprospinel
section_title: Catalyst for C-H activation
hierarchical_section_title: Cuprospinel / Recyclable catalyst for organic reactions / Catalyst for C-H activation
caption_attribution_description: English: C-H activation in Mannich type reaction. Adapted from the article - Catalysis Science &amp; Technology, 2014. 4(12): p. 4281- 4288.
context_page_description: Cuprospinel is a mineral that occurs naturally in Baie Verte, Newfoundland, Canada. The mineral was found in an exposed ore dump, on the property of Consolidated Rambler Mines Limited near Baie Verte, Newfoundland. The mineral was first characterized by Ernest Henry Nickel, a mineralogist with the Department of Energy, Mines and Resources in Australia, in 1973.
  Cuprospinel is an inverse spinel with the formula CuFe₂O₄, where copper substitutes some of the iron cations in the structure. Its structure is similar to that of magnetite, Fe₃O₄, yet with slightly different chemical and physical properties due to the presence of copper.
context_section_description: Nano CuFe₂O₄ catalyst was demonstrated its activity for C-H activation in Mannich type reaction. In the mechanistic study, the copper play a significant role in both generate radical from TBHP and activate C-H from substituted alkyne. In this reaction, iron center was considered as a magnetic source and this hypothesis was proved by the experiment, in which magnetic Fe3O4 had been used but failed to catalyze reaction in the absence of copper center.
caption: C-H activation in Mannich type reaction. Adapted from Nguyen et al. 2014.[16]
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