page_title: Arogenate dehydratase
section_title: Reaction
hierarchical_section_title: Arogenate dehydratase / Reaction
caption_attribution_description: English: Arogenate dehydratase converting prephenate to phenylpyruvate, carbon dioxide and water
context_page_description: Arogenate dehydratase is an enzyme that catalyzes the chemical reaction
  L-arogenate → L-phenylalanine + H₂O + CO₂
  Hence, this enzyme has one substrate, L-arogenate, but 3 products:L-phenylalanine, H₂O, and CO₂. Certain forms of the protein have the potential to catalyze a second reaction,
  L-prephenate → L-phenylpyruvate + H₂O + CO₂
  This enzyme participates in phenylalanine, tyrosine, and tryptophan biosynthesis
context_section_description: The carboxyl and hydroxide groups (shown in red) attached to the 2,5-cyclohexene ring are eliminated from L-arogenate, leaving as carbon dioxide and water. The 2,5-cyclohexene ring becomes a phenyl ring, and L-phenylalanine is formed.
  Certain forms of ADT have been shown to exhibit some prephenate dehydratase (PDT) activity in addition to the standard ADT activity described above. Known as cyclohexadienyl dehydratases or carbocyclohexadienyl dehydratases (listed above), these forms of the enzyme catalyze the same type of reaction (a decarboxylation and a dehydration) on prephenate. The carboxyl and hydroxide groups (in red) attached to the 2,5-cyclohexene ring are removed, leaving phenylpyruvate.
caption: Arogenate dehydratase converting prephenate to phenylpyruvate, carbon dioxide and water
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