page_title: 9aaTAD
section_title: The 9aaTAD activation domains
hierarchical_section_title: 9aaTAD / The 9aaTAD activation domains
caption_attribution_description: SP family evolution
context_page_description: The Nine amino acids TransActivation Domains have the competence to activate transcription as small peptides. They function universally in all eukaryotic systems, which means that any human 9aaTAD could activate transcription in the yeast and vice versa. The 9aaTAD characteristics are given by their universal function and by the amino acid pattern
  .
  The tandem hydrophobic clusters separated by a hydrophilic region are well balanced with hydrophilic amino acids, which may be either positively or negatively charged. From the structural data for the E2A and MLL in complex with the KIX domain, the 9aaTAD domains form short helices whose lengths vary from 9 to 12 aa
  .
  The 9aaTADs interact with one or with the multiple coactivators / mediators of transcription, e.g. p53, which interacts with all four domains of CBP/p300 but also with MED15, TAF9, GCN5, Tfb1 and other coactivators
  .
  Interaction with at least one of them will be sufficient for activation of transcription “activation by recruitment”
  .
context_section_description: The Nine amino acids TransActivation Domains (9aaTADs) have the competence to activate transcription as small peptides (9 to 14 amino acids long). They function universally in all eukaryotic systems, which means that any human 9aaTAD could activate transcription in the yeast and vice versa. The 9aaTAD characteristics are given by their universal function and by the amino acid pattern
  . 
  The tandem hydrophobic clusters separated by a hydrophilic region are well balanced with hydrophilic amino acids, which may be either positively or negatively charged. From the structural data for the E2A and MLL in complex with the KIX domain, the 9aaTAD domains form short helices whose lengths vary from 9 to 12 aa
  .
  The 9aaTADs interact with one or with the multiple coactivators / mediators of transcription, e.g. p53), which interacts with all four domains of CBP/p300 (KIX, TAZ1, TAZ2 and IBiD domains) but also with MED15, TAF9, GCN5, Tfb1 (subunit of TFIIH) and other coactivators
  .
  Interaction with at least one of them will be sufficient for activation of transcription “activation by recruitment”
  .
caption: SP family evolution
exif: {}