page_title: Phosphoribosyl-AMP cyclohydrolase
hierarchical_section_title: Phosphoribosyl-AMP cyclohydrolase
caption_attribution_description: English: Phosphoribosyl-AMP cyclohydrolase homodimer + Cd (purple), Methanothermobacter thermautotrophicus
context_page_description: In enzymology, a phosphoribosyl-AMP cyclohydrolase is an enzyme that catalyzes the chemical reaction
  1--AMP + H₂O 1--5-[methylideneamino]imidazole-4-carboxamide
  Thus, the two substrates of this enzyme are 1--AMP and H₂O, whereas its two products are [[1--5-[methylideneamino]imidazole-4-carboxamide]].
  This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is 1--AMP 1,6-hydrolase. Other names in common use include PRAMP-cyclohydrolase, and phosphoribosyladenosine monophosphate cyclohydrolase. This enzyme participates in histidine metabolism.
context_section_description: In enzymology, a phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) is an enzyme that catalyzes the chemical reaction
  1-(5-phosphoribosyl)-AMP + H₂O  1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4-carboxamide
  Thus, the two substrates of this enzyme are 1-(5-phosphoribosyl)-AMP and H₂O, whereas its two products are [[1-(5-phosphoribosyl)-5-[(5-]] and [[phosphoribosylamino)methylideneamino]imidazole-4-carboxamide]].
  This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines.  The systematic name of this enzyme class is 1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase. Other names in common use include PRAMP-cyclohydrolase, and phosphoribosyladenosine monophosphate cyclohydrolase.  This enzyme participates in histidine metabolism.
caption: phosphoribosyl-AMP cyclohydrolase dimer, Methanobacterium
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