page_title: Beta-propeller phytase
section_title: Motifs
hierarchical_section_title: Beta-propeller phytase / Structure / Motifs
caption_attribution_description: English: β-propeller phytase (BPP) motifs found by Huang et al. shown in a BPP (PDBID: 1H6L). Actual highlighted motifs are DAADDPAIW (red) and NNVDIRY (green). This picture is made with PyMOL version 2.0.4 and is based on the following study: Huang, Huoqing; Shao, Na; Wang, Yaru; Luo, Huiying; Yang, Peilong; Zhou, Zhigang; Zhan, Zhichun; Yao, Bin (2009-05-01). "A novel beta-propeller phytase from Pedobacter nyackensis MJ11 CGMCC 2503 with potential as an aquatic feed additive". Applied Microbiology and Biotechnology. 83 (2): 249. doi:10.1007/s00253-008-1835-1. ISSN 0175-7598.
context_page_description: β-propeller phytases are a group of enzymes with a round beta-propeller structure. BPPs are phytases, which means that they are able to remove phosphate groups from phytic acid and its phytate salts. Hydrolysis happens stepwise and usually ends in myo-inositol triphosphate product which has three phosphate groups still bound to it. The actual substrate of BPPs is calcium phytate and in order to hydrolyze it, BPPs must have Ca²⁺ ions bound to themselves. BPPs are the most widely found phytase superfamily in the environment and they are thought to have a major role in phytate-phosphorus cycling in soil and water. As their alternative name alkaline phytase suggests, BPPs work best in basic environment. Their pH optima is 6–9, which is unique among the phytases.
context_section_description: A 2008 study by Huang et al. compared 66 BPP peptide sequences and found that sequence motifs DA[A/T/E]DDPA[I/L/V]W and NN[V/I]D[I/L/V]R[Y/D/Q] were conserved in all of the studied BPPs. R[Y/D/Q] for example signifies that R and Y, D or Q were found in the sequence, i.e. RY or RD or RQ. 2014 study by Kumar et al. compared 44 BPPs and found 10 motifs. Two of these, DDPAIW[VI][HN]PK[DN]P[ESA]KS and NN[F/V]D[I/V/L], were found in all of the studied BPPs. These were noted to be similar to the ones found in the 2008 study by Huang et al.
caption: BPP motifs found by Huang et al.[10] shown in a BPP (PDBID: 1H6L). Actual highlighted motifs are DAADDPAIW (red) and NNVDIRY (green).
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