page_title: PDE10A
section_title: Inhibitors
hierarchical_section_title: PDE10A / Inhibitors
caption_attribution_description: English: The compound is an inhibitor of phosphodiesterase 10A and was synthesized by Michael Malamas et al. in 2011. In the article, the compound is compound 96. The file was made with Spartan '10, and the equilibrium geometry was calculated with the PM3 semi-empirical model. The digital object identifier of the reference is https://dx.doi.org/10.1021/jm2009138.
context_page_description: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A is an enzyme that in humans is encoded by the PDE10A gene.
  Various cellular responses are regulated by the second messengers cAMP and cGMP. Phosphodiesterases, such as PDE10A, eliminate cAMP- and cGMP-mediated intracellular signaling by hydrolyzing the cyclic nucleotide to the corresponding nucleoside 5-prime monophosphate.
context_section_description: Compound 96: IC₅₀ = 700 pM, high selectivity against all other members of the PDE family
  Papaverine
  PF-2545920
  TAK-063: IC₅₀ = 300 pM
  AMG 579
caption: 3d model of compound #96 (Malamas, 2011)[8]
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