page_title: LEAPER gene editing
section_title: Synopsis
hierarchical_section_title: LEAPER gene editing / Synopsis
caption_attribution_description: English: Structure of the ADAR protein. Based on PyMOL rendering of PDB 1qbj.
context_page_description: LEAPER is a genetic engineering technique in molecular biology by which RNA can be edited. The technique relies on engineered strands of RNA to recruit native ADAR enzymes to swap out different compounds in RNA. Developed by researchers at Peking University in 2019, the technique, some have claimed, is more efficient than the CRISPR gene editing technique. Initial studies have claimed that editing efiiciencies of up to 80% can be achieved.
context_section_description: The technique employs short engineered ADAR-recruiting RNAs (arRNAs) to recruit native ADAR1 or ADAR2 enzymes. These enzymes then change a specific adenosine to an inosine on a transcribed RNA. This results in a change in which protein is synthesized during translation.
caption: The technique utilizes native ADAR enzymes (pictured with RNA).
exif: {}