page_title: U.S. Route 278
section_title: Mississippi
hierarchical_section_title: U.S. Route 278 / Route description / Mississippi
caption_attribution_description: English: US 49, US 61 and US 278 in Mississippi
context_page_description: U.S. Route 278 is a parallel route of U.S. Route 78. It currently runs for 1,074 miles from Hilton Head Island, South Carolina to Wickes, Arkansas at U.S. Route 71/U.S. Route 59. It is longer than its parent highway, US 78. US 278 passes through the states of South Carolina, Georgia, Alabama, Mississippi, and Arkansas. This highway passes through the cities and towns of Augusta, Covington, Atlanta, Powder Springs, Hiram, Dallas, Rockmart, and Cedartown, Georgia; Gadsden and Cullman, Alabama; Tupelo, Oxford, and Greenville, Mississippi; and Monticello and Hope, Arkansas. It also passes through the Savannah River Site, of the Department of Energy in South Carolina, and crosses the Tennessee-Tombigbee Waterway in eastern Mississippi. U.S. 278 passes through the places where many colleges, universities, and technical institutes are located, including the Georgia Institute of Technology, Georgia State University, and many others in Atlanta, Georgia; the University of South Carolina - Beaufort, the Augusta University; the University of Mississippi, Delta State University, and the University of Arkansas at Monticello.
context_section_description: US 82 and US 278 go through Greenville to Leland, where US 278 separates from US 82 at U.S. Route 61. US 278 then joins US 61 northward through Cleveland before splitting in Clarksdale. East of Clarksdale, it overlaps Mississippi Highway 6 through Batesville, Oxford, and Pontotoc before reaching Tupelo. At Tupelo, MS 6 separates from US 278 while US 278 overlaps U.S. Route 45 south to New Wren. From New Wren, US 278 continues east through Amory before entering Alabama.
caption: US 49 and US 61 run with US 278 near Clarksdale, MS
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