page_title: Selective progesterone receptor modulator
section_title: Nonsteroidal SPRMs
hierarchical_section_title: Selective progesterone receptor modulator / Structure-activity relationships / Nonsteroidal SPRMs
caption_attribution_description: English: Trisubstituted thiophenes as PR antagonists with low potency
context_page_description: A selective progesterone receptor modulator is an agent that acts on the progesterone receptor, the biological target of progestogens like progesterone. A characteristic that distinguishes such substances from full receptor agonists and full antagonists is that their action differs in different tissues, i.e. agonist in some tissues while antagonist in others. This mixed profile of action leads to stimulation or inhibition in tissue-specific manner, which further raises the possibility of dissociating undesirable adverse effects from the development of synthetic PR-modulator drug candidates.
context_section_description: Progesterone receptor modulators with unique nonsteroidal structures are currently in the early stages of development (Fig. 5-12). Variety of new types of progesterone receptor antagonists with different degree of potency has been reported and show a remarkable structural diversity which can be seen in table below. Various lead compounds have also been identified as new progesterone receptor agonists. They can also be viewed in the table.
caption: Figure 6: Trisubstituted thiophenes as PR antagonists with low potency
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