page_title: CXorf38 Isoform 1
section_title: Tertiary Structure
hierarchical_section_title: CXorf38 Isoform 1 / Protein / Tertiary Structure
caption_attribution_description: English: CXorf38 Immunocytochemistry Localization
context_page_description: Chromosome X Open Reading Frame 38 is a protein which, in humans, is encoded by the CXorf38 gene. CXorf38 appears in multiple studies regarding the escape of X chromosome inactivation.
context_section_description: The space-filling model predicted by I-TASSER reveals an overall linear shape. The ribbon structure shows multiple alpha helices, coiled coils, and random coils. There is a known coiled coil region from Pro82 - Gln88, as well as a predicted coiled coil region from approximately Asn240 - Tyr255. Within the coiled coil region, there is a predicted nuclear export signal (NES) from Lys247-Leu256. Folding of the protein is predicted to leave ~30% of amino acids buried, ~60% exposed to the cytosol, and ~10% in an intermediate state. CXorf38 does not have any predicted high scoring hydrophobic segments or transmembrane segments.
caption: Localization in the cytosol, indicated in red. Image courtesy of Human Protein Atlas.[9]
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