page_title: Methylenetetrahydrofolate dehydrogenase (NADP+)
hierarchical_section_title: Methylenetetrahydrofolate dehydrogenase (NADP+)
caption_attribution_description: English: Methylenetetrahydrofolate dehydrogenase/cyclohydrolase (NADP) homodimer + 2 NADP (green-red) + 1 L34 inhibitor (l.blue-red), Human
context_page_description: In enzymology, a methylenetetrahydrofolate dehydrogenase (NADP+) is an enzyme that catalyzes the chemical reaction
  5,10-methylenetetrahydrofolate + NADP⁺ 5,10-methenyltetrahydrofolate + NADPH + H⁺
  Thus, the two substrates of this enzyme are 5,10-methylenetetrahydrofolate and NADP⁺, whereas its 3 products are 5,10-methenyltetrahydrofolate, NADPH, and H⁺.
  This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate:NADP+ oxidoreductase. Other names in common use include N5, N10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate:NADP oxidoreductase, 5,10-methylenetetrahydrofolate dehydrogenase, methylenetetrahydrofolate dehydrogenase, and methylenetetrahydrofolate dehydrogenase. This enzyme participates in glyoxylate and dicarboxylate metabolism and one carbon pool by folate.
context_section_description: In enzymology, a methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) is an enzyme that catalyzes the chemical reaction
  5,10-methylenetetrahydrofolate + NADP⁺  5,10-methenyltetrahydrofolate + NADPH + H⁺
  Thus, the two substrates of this enzyme are 5,10-methylenetetrahydrofolate and NADP⁺, whereas its 3 products are 5,10-methenyltetrahydrofolate, NADPH, and H⁺.
  This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor.  The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate:NADP+ oxidoreductase. Other names in common use include N5,N10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate:NADP oxidoreductase, 5,10-methylenetetrahydrofolate dehydrogenase, methylenetetrahydrofolate dehydrogenase, and methylenetetrahydrofolate dehydrogenase (NADP).  This enzyme participates in glyoxylate and dicarboxylate metabolism and one carbon pool by folate.
caption: Methylenetetrahydrofolate dehydrogenase dimer, Human
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