page_title: Integrin
hierarchical_section_title: Integrin
caption_attribution_description: English: Cartoon representation of the molecular structure of protein registered with 1jv2 code. Deutsch: Grafik des Molekularstruktur von jenem Protein, das mit 1jv2 code registriert ist. Plattdüütsch: Grafik, de de Molekularstruktur von dat Protein wiest, dat mit’n Kood 1jv2 registreert is.
context_page_description: Integrins are transmembrane receptors that facilitate cell-extracellular matrix adhesion. Upon ligand binding, integrins activate signal transduction pathways that mediate cellular signals such as regulation of the cell cycle, organization of the intracellular cytoskeleton, and movement of new receptors to the cell membrane. The presence of integrins allows rapid and flexible responses to events at the cell surface.
  Several types of integrins exist, and one cell may have multiple different types on its surface. Integrins are found in all animals while integrin-like receptors are found in plant cells.
  Integrins work alongside other proteins such as cadherins, the immunoglobulin superfamily cell adhesion molecules, selectins and syndecans, to mediate cell–cell and cell–matrix interaction. Ligands for integrins include fibronectin, vitronectin, collagen and laminin.
context_section_description: Integrins are transmembrane receptors that facilitate cell-extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal transduction pathways that mediate cellular signals such as regulation of the cell cycle, organization of the intracellular cytoskeleton, and movement of new receptors to the cell membrane. The presence of integrins allows rapid and flexible responses to events at the cell surface (e.g. signal platelets to initiate an interaction with coagulation factors).
  Several types of integrins exist, and one cell may have multiple different types on its surface. Integrins are found in all animals while integrin-like receptors are found in plant cells.
  Integrins work alongside other proteins such as cadherins, the immunoglobulin superfamily cell adhesion molecules, selectins and syndecans, to mediate cell–cell and cell–matrix interaction. Ligands for integrins include fibronectin, vitronectin, collagen and laminin.
caption: Structure of the extracellular segment of integrin alpha Vbeta3.[1]
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