page_title: C8orf34
section_title: Gene expression
hierarchical_section_title: C8orf34 / Gene / Gene expression
caption_attribution_description: English: This is microarray expression data for the gene C8orf34 processed and compiled into a viewable format.
context_page_description: C8orf34 is a protein that, in Homo sapiens, is encoded by the C8orf34 gene. Aliases for C8orf34 include vestibule-1 or VEST-1. Within the cell, C8orf34 is localized to the nucleus and nucleoli where it may play a role in the regulation of gene expression as well as the cell cycle.
context_section_description: Within the cell, C8orf34 is expressed primarily in the nucleus. C8orf34 protein lacks a signal peptide to allow it to sort outside of the nuclear membrane or to other organelles. An analysis via PSORT II concluded that C8orf34 is localized to the nucleus 94.1% reliability. This nuclear localization suggests that C8orf34 protein may have a function related to the expression and regulation of genes in the nucleus. Alternatively, it may be involved in the maintenance and protection of the cell's genetic material.
  C8orf34 is expressed in a wide array of tissues, including the kidney, stomach, thymus, pituitary gland, ear, and brain. In the brain, C8orf34 is expressed in the dentate gyrus, epithalamus, and medulla. In the mouse brain, an orthologous C8orf34 is expressed highly in the granule layer of the dentate gyrus, the somatosensory areas of the cerebral cortex and in the amygdala.
caption: Microarray data from 6 individuals showing the expression of C8orf34 in different regions of the brain. Areas of high expression are shown in red while areas of low expression are noted in green.[13]
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