page_title: Transmission electron microscopy DNA sequencing
section_title: Workflow
hierarchical_section_title: Transmission electron microscopy DNA sequencing / Workflow
caption_attribution_description: English: Workflow of Transmission Electron Microscopy DNA Sequencing
context_page_description: Transmission electron microscopy DNA sequencing is a single-molecule sequencing technology that uses transmission electron microscopy techniques. The method was conceived and developed in the 1960s and 70s, but lost favor when the extent of damage to the sample was recognized.
  In order for DNA to be clearly visualized under an electron microscope, it must be labeled with heavy atoms. In addition, specialized imaging techniques and aberration corrected optics are beneficial for obtaining the resolution required to image the labeled DNA molecule. In theory, transmission electron microscopy DNA sequencing could provide extremely long read lengths, but the issue of electron beam damage may still remain and the technology has not yet been commercially developed.
caption: Workflow of transmission electron microscopy DNA sequencing
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