page_title: Long-chain-alcohol oxidase
section_title: Structure
hierarchical_section_title: Long-chain-alcohol oxidase / Structure
caption_attribution_description: English: The long-chain alkane/omega-oxidation pathway. An enzyme of the cytochrome P450 family converts an alkane to an alcohol, which is converted to an aldehyde by an oxidase (or a dehydrogenase), which is converted to a carboxylic acid by a dehydrogenase.
context_page_description: Long-chain alcohol oxidase is one of two enzyme classes that oxidize long-chain or fatty alcohols to aldehydes. It has been found in certain Candida yeast, where it participates in omega oxidation of fatty acids to produce acyl-CoA for energy or industrial use, as well as in other fungi, plants, and bacteria.
context_section_description: The enzyme is an octamer of ~46kD subunits  (except in C. tropicalis, in which it is a dimer of subunits ~70kD). It is a Cytochrome c oxidase containing a covalently-bound heme group using the Cys-X-X-Cys-His motif. It also contains flavin to assist in oxidation-reduction. The enzyme is bound to the endoplasmic reticulum membrane.
  Long-chain fatty alcohol oxidases vary between species in their specificity; some species have multiple different alcohol oxidases. They generally have a broad range of substrates, ranging from short chain alcohols starting at 4 carbons to the longest long-chain alcohols at 22 carbons. Some can also oxidize select diols, secondary alcohols, hydroxy fatty acids, and even long-chain aldehydes. However, each enzyme is optimized to function for specific alcohol, often between 10 and 16 carbons. In at least one species, the enzyme was stereoselective for the R(-) entantiomer.
caption: The long-chain alkane/omega-oxidation pathway, from alkane to carboxylic acid.
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