page_title: Chalcone synthase
hierarchical_section_title: Chalcone synthase
caption_attribution_description: English: Chalcone Synthase X Ray Image PDG: 1BI5
context_page_description: Chalcone synthase or naringenin-chalcone synthase is an enzyme ubiquitous to higher plants and belongs to a family of polyketide synthase enzymes known as type III PKS. Type III PKSs are associated with the production of chalcones, a class of organic compounds found mainly in plants as natural defense mechanisms and as synthetic intermediates. CHS was the first type III PKS to be discovered. It is the first committed enzyme in flavonoid biosynthesis.
  The enzyme catalyzes the conversion of 4-coumaroyl-CoA and malonyl-CoA to naringenin chalcone.
context_section_description: Chalcone synthase or naringenin-chalcone synthase (CHS) is an enzyme ubiquitous to higher plants and belongs to a family of polyketide synthase enzymes (PKS) known as type III PKS. Type III PKSs are associated with the production of chalcones, a class of organic compounds found mainly in plants as natural defense mechanisms and as synthetic intermediates. CHS was the first type III PKS to be discovered. It is the first committed enzyme in flavonoid biosynthesis.
  The enzyme catalyzes the conversion of 4-coumaroyl-CoA and malonyl-CoA to naringenin chalcone.
caption: The structure of CHS from Medicago sativa.
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