page_title: Perilipin-5
section_title: Perilipin 5-Nucleus interactions
hierarchical_section_title: Perilipin-5 / Function / Perilipin 5-Nucleus interactions
caption_attribution_description: English: When needed, Protein Kinase A phosphorylate perilipin 5, allowing it to enter the nucleus, where it displaces DCB1, giving way to the necessary interactions to change gene expression
context_page_description: Perilipin 5, also known as Oxpatperilipin 5 or PLIN5, is a protein that belongs to perilipin family. This protein group has been shown to be responsible for lipid droplet's biogenesis, structure and degradation. In particular, Perilipin 5 is a lipid droplet-associated protein whose function is to keep the balance between lipolysis and lipogenesis, as well as maintaining lipid droplet homeostasis. For example, in oxidative tissues, muscular tissues and cardiac tissues, PLIN5 promotes association between lipid droplets and mitochondria.
  Inside the cell, PLIN5 can be found in multiple intracellular structures including lipid droplets, endoplasmic reticulum, mitochondria, and the cytosol. The wrong expression of this protein has been proven to be related with diseases such as skeletal muscle diseases, liver diseases or carcinogenesis.
context_section_description: The mechanism by which OXPAT5 balances energy remain to be fully clarified. It interacts mainly with LDs, though recent data suggest that this protein also targets the nucleus. When needed, perilipin 5 is phosphorylated by protein kinase A, which allows it to access the nucleus and enter the complex SIRT1/PGC-1α, involved in fatty acid oxidation. PLIN5 removes SIRT1 inhibitor DBC1, therefore increasing its activity. As a consequence, PGC-1α boost activity levels activating certain types of genes that enhances mitochondrial function.
caption: PLIN5 is phosphorylated and it accesses the nucleus displacing DBC1 inhibitor
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