page_title: Turbo-Hauser bases
section_title: Reactions
hierarchical_section_title: Turbo-Hauser bases / Reactions
caption_attribution_description: English: Example Turbo Hauser Base Rktn General
context_page_description: Turbo-Hauser bases are amido magnesium halides that contain stoichiometric amounts of LiCl. These mixed Mg/Li amides of the type R₂NMgCl⋅LiCl are used in organic chemistry as non-nucleophilic bases for metalation reactions of aromatic and heteroaromatic substrates. Compared to their LiCl free ancestors Turbo-Hauser bases show an enhanced kinetic basicity, excellent regioselectivity, high functional group tolerance and a better solubility.
context_section_description: In contrast to Turbo-Grignard compounds that are used for highly efficient Br/Mg exchange reactions, Turbo-Hauser bases are used as effective deprotonation reagents of functionalized aromatics. After deprotonation, the intermediate product (a Turbo-Grignard) can selectively be functionalized via addition of an electrophile (e.g. I₂, -CHO).
caption: General reaction path of a Turbo-Hauser base reaction
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