page_title: HGH-hPL
section_title: Structure and location
hierarchical_section_title: HGH-hPL / Structure and location
caption_attribution_description: English: This is a draft about the structure and location of hGh-hPL
context_page_description: The multigenic complex formed by the human growth hormone and the human placental lactogen takes part in the process of maternal and fetal metabolism regulation and the following growth and development of the fetus
context_section_description: The hGH-hPL multigene family is located in the 17th chromosome, concretely between the q22 and q24 regions occupying an approximately 50.000 pairs of nitrogen bases area. It is formed by 5 genes: two hGH and three hPL with a similarity between 91% and 95%:
  hGH-N: expressed in the pituitary gland somatotroph. It is the only one from this multigene family expressed in the hypophysis
  hGH-V: expressed in low levels in the placenta. It codifies for a GH variety.
  hPL-1: pseudogene also found in the placenta that contains a mutation which avoids its removal.
  hPL-3 and hPL-4: found in the placenta. They codify for a lactogenic hormone also found in the placenta.
  The similarity of this five genes is shown in their function, as it has been exposed previously, but also in their structure. Each of them is formed by 5 exons and 4 introns. Their length is also very similar. Moreover, the three hPL genes, which are all found in the placenta, contain an enhancer sequence (DNA sequence that increases the transcription levels in gene family).
  Regarding the intergenic space, this has a length between 6000 and 13000 pb (1pb, picobarn = 10⁻³⁶ cm²). This space is filled with a serie of intergenic sequences repeated along the complex. The function of this sequences hasn't been clearly defined yet.
caption: Structure and location
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