page_title: Striosome
hierarchical_section_title: Striosome
caption_attribution_description: English: immunochistochemical staining of striatum (mouse brain)
context_page_description: The striosomes are one of two complementary chemical compartments within the striatum that can be visualized by staining for immunocytochemical markers such as acetylcholinesterase, enkephalin, substance P, limbic system-associated membrane protein, AMPA receptor subunit 1, dopamine receptor subunits, and calcium binding proteins. Striosomal abnormalities have been associated with neurological disorders, such as mood dysfunction in Huntington's disease, though their precise function remains unknown. Striosomes were discovered by Ann Graybiel in 1978 using acetylcholinesterase histochemistry.
context_section_description: The striosomes (also referred to as the striatal patches) are one of two complementary chemical compartments within the striatum (the other compartment is known as the matrix) that can be visualized by staining for immunocytochemical markers such as acetylcholinesterase, enkephalin, substance P, limbic system-associated membrane protein (LAMP), AMPA receptor subunit 1 (GluR1), dopamine receptor subunits, and calcium binding proteins.   Striosomal abnormalities have been associated with neurological disorders, such as mood dysfunction in Huntington's disease, though their precise function remains unknown.  Striosomes were discovered by Ann Graybiel in 1978 using acetylcholinesterase histochemistry.
caption: Matrix and Striosome Compartments: Fluorescence microscopy image of a coronal mouse brain section, cut through the striatum (caudate putamen, CP). The matrix/striosome division is here revealed by dual immunohistochemical (calbindin, CALB; green) and transgenic (red fluorescent protein, RFP; red) labeling of the matrix compartment, using the matrix-specific Cre-mouse line Gpr101-Cre.[6] Unlabeled patches constitute striosomes.
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