page_title: IFFO1
section_title: Structure
hierarchical_section_title: IFFO1 / Protein / Structure
caption_attribution_description: English: Tertiary structure of IFFO1 protein as predicted by PHYRE2 program
context_page_description: Intermediate filament family orphan 1 is a protein that in humans is encoded by the IFFO1 gene. IFFO1 has uncharacterized function and a weight of 61.98 kDa. IFFO1 proteins play an important role in the cytoskeleton and the nuclear envelope of most eukaryotic cell types.
context_section_description: The predicted secondary structure of the protein consists mostly of alpha helices (47.19%) and random coils (44.74%). The building block of intermediate filaments are elongated coiled-coil dimer consisting of four consecutive alpha-helical segments.
   Structurally, it is most similar to 1GK4, which is chain A of the human vimentin coil 2b fragment (Cys2). Vimentin is a class-II intermediate filament that is found in various non-epithelial cells, especially mesenchymal cells. The vimentin protein is also responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. Its 1A subunit, most similar to IFFO1 protein, forms a single, amphipatic alpha-helix that's compatible with a coiled-coil geometry. It is speculated that this chain is involved in specific dimer-dimer interactions during intermediate filament assembly. A "YRKLLEGEE" domain on the C-terminus is found to be important for the formation of authentic tetrameric complexes and also for the control of filament width during assembly.
caption: Tertiary structure of IFFO1 protein as predicted by PHYRE2 program
exif: {}