page_title: CCR4-Not
hierarchical_section_title: CCR4-Not
caption_attribution_description: English: Structure of the NOT module of the human CCR4-Not complex, solved at 3.2 Å (PDB 4C0D). CNOT1 is green, CNOT2 is magenta, and CNOT3 is yellow.
context_page_description: Carbon Catabolite Repression—Negative On TATA-less, or CCR4-Not, is a multiprotein complex that functions in gene expression. The complex has multiple enzymatic activities as both a poly 3′-5′ exonuclease and a ubiquitin ligase. The complex is present both in the nucleus where it regulates transcription and in the cytoplasm where it associates with translating ribosomes and RNA processing bodies.
context_section_description: Carbon Catabolite Repression—Negative On TATA-less, or CCR4-Not, is a multiprotein complex that functions in gene expression. The complex has multiple enzymatic activities as both a poly(A) 3′-5′ exonuclease and a ubiquitin ligase. The complex is present both in the nucleus where it regulates transcription and in the cytoplasm where it associates with translating ribosomes and RNA processing bodies.
caption: Structure of human CNOT1-CNOT2-CNOT3 module (PDB 4C0D).[1]
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