page_title: Dihydroorotate dehydrogenase (quinone)
hierarchical_section_title: Dihydroorotate dehydrogenase (quinone)
caption_attribution_description: English: Enzymatic reaction catalyzed by DHOQO (green). Protein is sitting on top of a lipid membrane (in gray)
context_page_description: Class 2 dihydroorotate dehydrogenases is an enzyme with systematic name-dihydroorotate:quinone oxidoreductase. This enzyme catalyses the electron transfer from dihydroorotate to a quinone:
  -dihydroorotate + quinone orotate + quinol
  These enzymes differ from class 1 dihydroorotate dehydrogenases on the electron acceptor, on their structure, and on their cellular localization. Since the reaction catalyzed by DHOQOs is both part of the electron transport chain and the pyrimidine de novo synthesis, it has been explored as a possible target for cancer treatment, immunological disorders and bacterial/viral infections.
context_section_description: Class 2 dihydroorotate dehydrogenases (DHOQO, EC 1.3.5.2) is an enzyme with systematic name (S)-dihydroorotate:quinone oxidoreductase. This enzyme catalyses the electron transfer from  dihydroorotate (electron donor) to a quinone (electron acceptor):
  (S)-dihydroorotate + quinone  orotate + quinol
  These enzymes differ from class 1 dihydroorotate dehydrogenases (DHODH) on the electron acceptor, on their structure, and on their cellular localization. Since the reaction catalyzed by DHOQOs is both part of the electron transport chain and the pyrimidine de novo synthesis, it has been explored as a possible target for cancer treatment, immunological disorders and bacterial/viral infections.
caption: Enzymatic reaction catalyzed by NDH-2. In yellow is represented the protein surface, sitting in the membrane (in gray)
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