page_title: Argininosuccinate lyase
hierarchical_section_title: Argininosuccinate lyase
caption_attribution_description: English: ASL Tetramer at 50 percent
context_page_description: ASL is an enzyme that catalyzes the reversible breakdown of argininosuccinate producing the amino acid arginine and dicarboxylic acid fumarate. Located in liver cytosol, ASL is the fourth enzyme of the urea cycle and involved in the biosynthesis of arginine in all species and the production of urea in ureotelic species. Mutations in ASL, resulting low activity of the enzyme, increase levels of urea in the body and result in various side effects.
  The ASL gene is located on chromosome 7 between the centromere and the long arm at position 11.2, from base pair 64,984,963 to base pair 65,002,090.
  ASL is related to intragenic complementation.
context_section_description: ASL (argininosuccinate lyase, also known as argininosuccinase) is an enzyme that catalyzes the reversible breakdown of argininosuccinate (ASA) producing the amino acid arginine and dicarboxylic acid fumarate. Located in liver cytosol, ASL is the fourth enzyme of the urea cycle and involved in the biosynthesis of arginine in all species and the production of urea in ureotelic species. Mutations in ASL, resulting low activity of the enzyme, increase levels of urea in the body and result in various side effects.
  The ASL gene is located on chromosome 7 between the centromere (junction of the long and short arm) and the long (q) arm at position 11.2, from base pair 64,984,963 to base pair 65,002,090.
  ASL is related to intragenic complementation.
caption: Crystal structure of duck argininosuccinate lyase with bound argininosuccinate.[1]
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