page_title: Carbamoyl phosphate synthetase
hierarchical_section_title: Carbamoyl phosphate synthetase
caption_attribution_description: English: Cartoon representation of the molecular structure of protein registered with 1dv2 code. Deutsch: Grafik des Molekularstruktur von jenem Protein, das mit 1dv2 code registriert ist. Plattdüütsch: Grafik, de de Molekularstruktur von dat Protein wiest, dat mit’n Kood 1dv2 registreert is.
context_page_description: Carbamoyl phosphate synthetase catalyzes the ATP-dependent synthesis
  of carbamoyl phosphate from glutamine or ammonia and bicarbonate. This enzyme catalyzes the reaction of ATP and bicarbonate to produce carboxy phosphate and ADP. Carboxy phosphate reacts with ammonia to give carbamic acid. In turn, carbamic acid reacts with a second ATP to give carbamoyl phosphate plus ADP.
  It represents the first committed step in pyrimidine and arginine biosynthesis in prokaryotes and eukaryotes, and in the urea cycle in most terrestrial vertebrates. Most prokaryotes carry one form of CPSase that participates in both arginine and pyrimidine biosynthesis, however certain bacteria can have separate forms.
  There are three different forms that serve very different functions:
  Carbamoyl phosphate synthetase I
  Carbamoyl phosphate synthetase II.
  Carbamoyl phosphate synthetase III.
context_section_description: Carbamoyl phosphate synthetase catalyzes the ATP-dependent synthesis
  of carbamoyl phosphate from glutamine (EC 6.3.5.5) or ammonia (EC 6.3.4.16) and bicarbonate. This enzyme catalyzes the reaction of ATP and bicarbonate to produce carboxy phosphate and ADP. Carboxy phosphate reacts with ammonia to give carbamic acid. In turn, carbamic acid reacts with a second ATP to give carbamoyl phosphate plus ADP.
  It represents the first committed step in pyrimidine and arginine biosynthesis in prokaryotes and eukaryotes, and in the urea cycle in most terrestrial vertebrates. Most prokaryotes carry one form of CPSase that participates in both arginine and pyrimidine biosynthesis, however certain bacteria can have separate forms.
  There are three different forms that serve very different functions:
  Carbamoyl phosphate synthetase I (mitochondria, urea cycle)
  Carbamoyl phosphate synthetase II (cytosol, pyrimidine metabolism).
  Carbamoyl phosphate synthetase III (found in fish).
caption: the structure of biotin carboxylase, mutant e288k, complexed with atp
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