page_title: SH-SY5Y
hierarchical_section_title: SH-SY5Y
caption_attribution_description: This photo illustrates the growth pattern of the SH-SY5Y neuroblastoma cell line. Author: Reid Offringa Iamnotanorange
context_page_description: SH-SY5Y is a human derived cell line used in scientific research. The original cell line, called SK-N-SH, from which it was subcloned was isolated from a bone marrow biopsy taken from a four-year-old female with neuroblastoma. SH-SY5Y cells are often used as in vitro models of neuronal function and differentiation. They are adrenergic in phenotype but also express dopaminergic markers and, as such, have been used to study Parkinson's disease, neurogenesis, and other characteristics of brain cells.
context_section_description: SH-SY5Y is a human derived cell line used in scientific research. The original cell line, called SK-N-SH, from which it was subcloned was isolated from a bone marrow biopsy taken from a four-year-old female with neuroblastoma. SH-SY5Y cells are often used as in vitro models of neuronal function and differentiation. They are adrenergic in phenotype but also express dopaminergic markers and, as such, have been used to study Parkinson's disease, neurogenesis, and other characteristics of brain cells.
caption: SH-SY5Y cells can form mounds of undifferentiated cells, which then spread differentiated cells into the surrounding area. This growth formation can be referred to as the "over-easy formation"
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