page_title: Acetoacetyl-CoA reductase
hierarchical_section_title: Acetoacetyl-CoA reductase
caption_attribution_description: English: Acetoacetyl-CoA reductase homotetramer + 4 acetoacetyl-CoA (green-red) + 4 NADP (l.blue-red) + 4 SO4 (yellow-red), Cupriavidus necator
context_page_description: In enzymology, an acetoacetyl-CoA reductase is an enzyme that catalyzes the chemical reaction
  -3-hydroxyacyl-CoA + NADP⁺ 3-oxoacyl-CoA + NADPH + H⁺
  Thus, the two substrates of this enzyme are-3-hydroxyacyl-CoA and NADP⁺, whereas its 3 products are 3-oxoacyl-CoA, NADPH, and H⁺.
  This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is-3-hydroxyacyl-CoA:NADP⁺ oxidoreductase. Other names in common use include acetoacetyl coenzyme A reductase, hydroxyacyl coenzyme-A dehydrogenase, NADP⁺-linked acetoacetyl CoA reductase, NADPH:acetoacetyl-CoA reductase, D-beta-hydroxybutyryl CoA-NADP⁺ oxidoreductase, short chain beta-ketoacetyl-CoA reductase, beta-ketoacyl-CoA reductase, D-3-hydroxyacyl-CoA reductase, and-3-hydroxyacyl-CoA dehydrogenase. This enzyme participates in butanoate metabolism.
context_section_description: In enzymology, an acetoacetyl-CoA reductase (EC 1.1.1.36) is an enzyme that catalyzes the chemical reaction
  (R)-3-hydroxyacyl-CoA + NADP⁺  3-oxoacyl-CoA + NADPH + H⁺
  Thus, the two substrates of this enzyme are (R)-3-hydroxyacyl-CoA and NADP⁺, whereas its 3 products are 3-oxoacyl-CoA, NADPH, and H⁺.
  This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-3-hydroxyacyl-CoA:NADP⁺ oxidoreductase. Other names in common use include acetoacetyl coenzyme A reductase, hydroxyacyl coenzyme-A dehydrogenase, NADP⁺-linked acetoacetyl CoA reductase, NADPH:acetoacetyl-CoA reductase, D(−)-beta-hydroxybutyryl CoA-NADP⁺ oxidoreductase, short chain beta-ketoacetyl(acetoacetyl)-CoA reductase, beta-ketoacyl-CoA reductase, D-3-hydroxyacyl-CoA reductase, and (R)-3-hydroxyacyl-CoA dehydrogenase. This enzyme participates in butanoate metabolism.
caption: Acetoacetyl-CoA reductase tetramer, Cupriavidus necator
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