page_title: Papanicolaou stain
hierarchical_section_title: Papanicolaou stain
caption_attribution_description: English: Micrograph showing a low grade squamous intraepithelial lesion (LSIL). Pap test. Pap stain. LSIL is an abnormality found on a pap test that consists of cells that are abnormal and may develop into cervical cancer. Abnormal cells have an enlarged nucleus, irregular chromatin and relatively abundant cytoplasm. Binucleation (two nuclei in one cell) and peri-nuclear glycogen are commonly seen. Related images LSIL. HSIL. Adenocarcinoma.
context_page_description: Papanicolaou stain is a multichromatic cytological staining technique developed by George Papanicolaou in 1942. The Papanicolaou stain is one of the most widely used stains in cytology, where it is used to aid pathologists in making a diagnosis. Although most notable for its use in the detection of cervical cancer in the Pap test or Pap smear, it is also used to stain non-gynecological specimen preparations from a variety of bodily secretions and from small needle biopsies of organs and tissues. Papanicolaou published three formulations of this stain in 1942, 1954, and 1960.
context_section_description: Papanicolaou stain (also Papanicolaou's stain and Pap stain) is a multichromatic (multicolored) cytological staining technique developed by George Papanicolaou in 1942. The Papanicolaou stain is one of the most widely used stains in cytology, where it is used to aid pathologists in making a diagnosis. Although most notable for its use in the detection of cervical cancer in the Pap test or Pap smear, it is also used to stain non-gynecological specimen preparations from a variety of bodily secretions and from small needle biopsies of organs and tissues. Papanicolaou published three formulations of this stain in 1942, 1954, and 1960.
caption: Papanicolaou stain showing a low-grade squamous intraepithelial lesion (LSIL) from a Pap test. Cell nuclei stained blue.
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