page_title: Notch 3
section_title: Pathology
hierarchical_section_title: Notch 3 / Pathology
caption_attribution_description: English: Very high magnification micrograph of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Notch 3 immunohistochemical staining. In CADASIL, the small vessels show a characteristic punctate staining of smooth muscle and pericytes with Notch 3.&#91;1&#93; References ↑ Lesnik Oberstein SA, Jukema JW, Van Duinen SG, et al.&#32;(July 2003).&#32;"Myocardial infarction in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)". Medicine (Baltimore)&#32;82&#32;(4): 251–6. DOI:10.1097/01.md.0000085054.63483.40. PMID 12861102.
context_page_description: Neurogenic locus notch homolog protein 3 is a protein that in humans is encoded by the NOTCH3 gene.
context_section_description: Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Mutations in NOTCH3 have also been identified in a Turkish family with Alzheimer's disease. Adult Notch3 knock-out mice show incomplete neuronal maturation in the spinal cord dorsal horn, resulting in permanently increased nociceptive sensitivity.
  Mutations in NOTCH3 are associated to lateral meningocele syndrome.
caption: Micrograph showing CADASIL with a Notch 3 immunostain.
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