page_title: Gliogenesis
section_title: Signaling inhibition
hierarchical_section_title: Gliogenesis / Gliogenesis regulation / Signaling inhibition
caption_attribution_description: English: Schematic showing high-level multi-step process of neurogenesis and gliogenesis. Activation of proneural genes by EGF and FGF results in neural stem cell (NSC) differentiation. Upon Notch-Delta signaling between neighboring NSCs, a subset of cells will become neuronal progenitors (giving rise to neurons), whereas the inhibited cells will become glial progenitors (giving rise to astrocytes and oligodendrocytes).
context_page_description: Gliogenesis is the generation of non-neuronal glia populations derived from multipotent neural stem cells.
context_section_description: During periods in which glial cell formation is discouraged, neural stem cells have the option to remain pluripotent or switch pathway lineages and begin forming neurons during neurogenesis. If neuron development is instructed, neurogenic factors, i.e. BMPs, are present to induce expression of proneural transcription factors like Neurogenin and ASCL1. These transcription factors function to interact with transcription factors generated from Notch signaling. Consequently, this complex is sequestered away from promoters activating gliogenesis and now directed to promoters that influence activity directed for neuron development. Neurogenin proteins regulate JAK/STAT signaling by similar mechanisms.
caption: Stem cell differentiation and Notch-Delta lateral inhibition in neural stem cells, resulting in the generation of neuronal and glia progenitors.
exif: {}