page_title: Structural bioinformatics
section_title: Protein Data Bank (PDB)
hierarchical_section_title: Structural bioinformatics / Protein Data Bank (PDB)
caption_attribution_description: English: The number of structures from PDB. (A) The overall growth of released structures in Protein DataBank per year. (B) Growth of structures deposited in PDB from X-ray crystallography, NMR spectroscopy, and 3D electron microscopy experiments per year. Source: https://www.rcsb.org/stats/growth
context_page_description: Structural bioinformatics is the branch of bioinformatics that is related to the analysis and prediction of the three-dimensional structure of biological macromolecules such as proteins, RNA, and DNA. It deals with generalizations about macromolecular 3D structures such as comparisons of overall folds and local motifs, principles of molecular folding, evolution, and binding interactions, and structure/function relationships, working both from experimentally solved structures and from computational models. The term structural has the same meaning as in structural biology, and structural bioinformatics can be seen as a part of computational structural biology. Structural bioinformatics main objectives are the creation of new methods to deal with biological macromolecules data to solve problems in biology and generate new knowledge.
context_section_description: The Protein Data Bank (PDB) is a database of 3D structure data for large biological molecules, such as proteins, DNA, and RNA. PDB is managed by an international organization called the Worldwide Protein Data Bank (wwPDB), which is composed of several local organizations, as. PDBe, PDBj, RCSB, and BMRB. They are responsible for keeping copies of PDB data available on the internet at no charge. The number of structure data available at PDB has increased each year, being obtained typically by X-ray crystallography, NMR spectroscopy, or cryo-electron microscopy.
caption: The number of structures from PDB. (A) The overall growth of released structures in Protein DataBank per year. (B) Growth of structures deposited in PDB from X-ray crystallography, NMR spectroscopy, and 3D electron microscopy experiments per year. Source: https://www.rcsb.org/stats/growth
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