page_title: SimThyr
section_title: Scientific uses
hierarchical_section_title: SimThyr / Scientific uses
caption_attribution_description: English: SimThyr used for educational purposes in a computer resource centre
context_page_description: SimThyr is a free continuous dynamic simulation program for the pituitary-thyroid feedback control system. The open-source program is based on a nonlinear model of thyroid homeostasis. In addition to simulations in the time domain the software supports various methods of sensitivity analysis. It provides a GUI, which allows for visualising time series, modifying constant structure parameters of the feedback loop, storing parameter sets as XML files and exporting results of simulations in various formats that are suitable for statistical software. SimThyr is primarily intended for educational purposes and in-silico research.
context_section_description: Multiple studies employed SimThyr for in silico research on the control of thyroid function.
  The original version was developed to check hypotheses about the generation of pulsatile TSH release. Later and expanded versions of the software were used to develop the hypothesis of the TSH-T3 shunt in the hypothalamus-pituitary-thyroid axis, to assess the validity of calculated parameters of thyroid homeostasis (including SPINA-GT and SPINA-GD) and to study allostatic mechanisms leading to non-thyroidal illness syndrome.
  SimThyr was also used to show that the release rate of thyrotropin is controlled by multiple factors other than T4 and that the relation between free T4 and TSH may be different in euthyroidism, hypothyroidism and thyrotoxicosis.
caption: SimThyr used for educational purposes in a computer resource centre
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