page_title: Agnoprotein
section_title: Expression
hierarchical_section_title: Agnoprotein / Expression
caption_attribution_description: English: Schematic of the circular viral DNA genome of the John Cunningham (JC) virus showing locations of genes and the non-coding control region (NCCR). From the following paper: Wharton KA Jr, Quigley C, Themeles M, Dunstan RW, Doyle K, et al. (2016) JC Polyomavirus Abundance and Distribution in Progressive Multifocal Leukoencephalopathy (PML) Brain Tissue Implicates Myelin Sheath in Intracerebral Dissemination of Infection. PLoS ONE 11(5): e0155897. doi: 10.1371/journal.pone.0155897
context_page_description: Agnoprotein is a protein expressed by some members of the polyomavirus family from a gene called the agnogene. Polyomaviruses in which it occurs include two human polyomaviruses associated with disease, BK virus and JC virus, as well as the simian polyomavirus SV40.
context_section_description: Agnoprotein is expressed from a region of the circular viral genome called the agnogene, an open reading frame contained in a region of the polyomavirus genome that codes for the viral capsid proteins and is known as the "late region" because it is expressed late in the cycle of viral infection and replication. The agnogene and its protein product received their name (from the Greek agnosis, "without knowledge") because the presence of the open reading frame and corresponding RNA was detected before the existence of the protein product was confirmed.
caption: A map of the genome of JC virus, indicating the position of the agnogene (yellow) in the late region relative to the other coding genes and to the non-coding control region (NCCR).[5]
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