page_title: Eukaryotic translation initiation factor 4E family
hierarchical_section_title: Eukaryotic translation initiation factor 4E family
caption_attribution_description: English: Cartoon representation of the molecular structure of protein registered with 1ej4 code. Deutsch: Grafik des Molekularstruktur von jenem Protein, das mit 1ej4 code registriert ist. Plattdüütsch: Grafik, de de Molekularstruktur von dat Protein wiest, dat mit’n Kood 1ej4 registreert is.
context_page_description: In molecular biology, the eukaryotic translation initiation factor 4E family is a family of proteins that bind to the cap structure of eukaryotic cellular mRNAs. Members of this family recognise and bind the 7-methyl-guanosine-containing cap during an early step in the initiation of protein synthesis and facilitate ribosome binding to an mRNA by inducing the unwinding of its secondary structures. A tryptophan in the central part of the sequence of human eIF-4E seems to be implicated in cap-binding.
  Members of this family include EIF4E, EIF4E2, EIF4E3 and EIF4E1B.
context_section_description: In molecular biology, the eukaryotic translation initiation factor 4E family (eIF-4E) is a family of proteins that bind to the cap structure of eukaryotic cellular mRNAs. Members of this family recognise and bind the 7-methyl-guanosine-containing (m7Gppp) cap during an early step in the initiation of protein synthesis and facilitate ribosome binding to an mRNA by inducing the unwinding of its secondary structures. A tryptophan in the central part of the sequence of human eIF-4E seems to be implicated in cap-binding.
  Members of this family include EIF4E, EIF4E2, EIF4E3 and EIF4E1B.
caption: cocrystal structure of eif4e/4e-bp1 peptide
exif: {}