page_title: Doublecortin
section_title: Structure
hierarchical_section_title: Doublecortin / Structure
caption_attribution_description: English: Cartoon representation of the molecular structure of protein registered with 1uf0 code. Deutsch: Grafik des Molekularstruktur von jenem Protein, das mit 1uf0 code registriert ist. Plattdüütsch: Grafik, de de Molekularstruktur von dat Protein wiest, dat mit’n Kood 1uf0 registreert is.
context_page_description: Neuronal migration protein doublecortin, also known as doublin or lissencephalin-X is a protein that in humans is encoded by the DCX gene.
context_section_description: The detailed sequence analysis of Doublecortin and Doublecortin-like proteins allowed the identification of a tandem repeat of evolutionarily conserved Doublecortin (DC) domains. These domains are found in the N terminus of proteins and consists of tandemly repeated copies of an around 80 amino acids region. It has been suggested that the first DC domain of Doublecortin binds tubulin and enhances microtubule polymerisation.
  Doublecortin has been shown to influence the structure of microtubules. Microtubule nucleated in vitro in the presence of Doublecortin have almost exclusively 13 protofilaments, whereas microtubule nucleated without Doublecortin are present in a range of different sizes.
caption: solution structure of the N-terminal dcx domain of human doublecortin-like kinase
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