page_title: Hepatocyte nuclear factors
section_title: HNF1
hierarchical_section_title: Hepatocyte nuclear factors / Members / HNF1
context_page_description: Hepatocyte nuclear factors are a group of phylogenetically unrelated transcription factors that regulate the transcription of a diverse group of genes into proteins. These proteins include blood clotting factors and in addition, enzymes and transporters involved with glucose, cholesterol, and fatty acid transport and metabolism.
context_section_description: Members of the HNF1 subfamily contain a POU-homeodomain and bind to DNA as homodimers. 
  HNF1α/TCF1/MODY3 (TCF1)
  HNF1β/TCF2/MODY5 (TCF2)
caption: Structure of the hepatocyte nuclear factor 1A (green cartoon) bound to DNA (magenta) based on the crystallographic coordinates PDB: 1IC8​.
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