page_title: Opioid use disorder
section_title: Opioid overdose
hierarchical_section_title: Opioid use disorder / Signs and symptoms / Opioid overdose
caption_attribution_description: English: Fentanyl. 2 mg. A lethal dose in most people
context_page_description: Opioid use disorder is a substance use disorder relating to the use of an opioid. Any such disorder causes significant impairment or distress. Signs of the disorder include a strong desire to use opioids, increased tolerance to opioids, difficulty fulfilling obligations, trouble reducing use, and withdrawal symptoms with discontinuation. Opioid withdrawal symptoms may include nausea, muscle aches, diarrhea, trouble sleeping, agitation, and a low mood. Addiction and dependence are components of a substance use disorder. Complications may include opioid overdose, suicide, HIV/AIDS, hepatitis C, and problems at school, work, or home.
  Opioids include substances such as heroin, morphine, fentanyl, codeine, oxycodone, and hydrocodone. In the United States, a majority of heroin users begin by using prescription opioids, that may also be bought illegally. Risk factors for misuse include a history of substance use, substance use among family and friends, mental illness, low socioeconomic status, and race. Diagnosis may be based on criteria by the American Psychiatric Association in the DSM-5.
context_section_description: Signs and symptoms of opioid overdose include, but are not limited to:	
  Pin-point pupils may occur. Patient presenting with dilated pupils may still be suffering an opioid overdose.
  Decreased heart rate
  Decreased body temperature
  Decreased breathing
  Altered level of consciousness. People may be unresponsive or unconscious.
  Pulmonary edema (fluid accumulation in the lungs)
  Shock
  Death
caption: Fentanyl 2 mg. A lethal dose in most people.[27]
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