page_title: Steroid sulfatase
section_title: Function
hierarchical_section_title: Steroid sulfatase / Function
caption_attribution_description: English: Distribution of steroid sulfatase (STS) and estrogen sulfotransferase (EST) activities in adult human tissues. STS was measured as conversion of estrone sulfate (E1S) into estrone (E1), and EST was measured as conversion of estrone (E1) into estrone sulfate (E1S). Source of values: (December 2002). "Systemic distribution of steroid sulfatase and estrogen sulfotransferase in human adult and fetal tissues". J. Clin. Endocrinol. Metab. 87 (12): 5760–8. DOI:10.1210/jc.2002-020670. PMID 12466383.
context_page_description: Steroid sulfatase, or steryl-sulfatase, formerly known as arylsulfatase C, is a sulfatase enzyme involved in the metabolism of steroids. It is encoded by the STS gene.
context_section_description: The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors to the free steroid. This includes DHEA sulfate, estrone sulfate, pregnenolone sulfate, and cholesterol sulfate, all to their unconjugated forms (DHEA, estrone, pregnenolone, and cholesterol, respectively). The encoded protein is found in the endoplasmic reticulum, where it is present as a homodimer.
caption: Distribution of STS and EST activities for interconversion of estrone (E1) and estrone sulfate (E1S) in adult human tissues.[6]
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