page_title: History of cancer chemotherapy
section_title: Targeted therapy
hierarchical_section_title: History of cancer chemotherapy / Targeted therapy
caption_attribution_description: Crystal structure of the c-abl kinase domain (green) in complex with Sti-571 (imatinib, red).Rendered with Accelrys DS Visualizer Pro 1.6 and edited in the GIMP.Conformation and style made to match w:Image:Bcr abl sti.jpg, originally created by Mxpule for use in Wikipedia.
context_page_description: The era of cancer chemotherapy began in the 1940s with the first use of nitrogen mustards and folic acid antagonist drugs. The targeted therapy revolution has arrived, but many of the principles and limitations of chemotherapy discovered by the early researchers still apply.
context_section_description: Molecular genetics has uncovered signalling networks that regulate cellular activities such as proliferation and survival. In a particular cancer, such a network may be radically altered, due to a chance somatic mutation. Targeted therapy inhibits the metabolic pathway that underlies that type of cancer's cell division.
caption: bcr-abl kinase, which causes CML, inhibited by imatinib (small molecule).
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