page_title: SBK3
section_title: Post-translational modifications
hierarchical_section_title: SBK3 / Regulation / Protein level regulation / Post-translational modifications
caption_attribution_description: English: SBK3 Post-Translational Modifications
context_page_description: SH3 Domain Binding Kinase Family Member 3 is an enzyme that in humans is encoded by the SBK3 gene. SBK3 is a member of the serine/threonine protein kinase family. The SBK3 protein is known to exhibit transferase activity, especially phosphotransferase activity, and tyrosine kinase activity. It is well-conserved throughout mammalian organisms and has two paralogs: SBK1 and SBK2.
context_section_description: SBK3 has 29 proposed phosphorylation sites at various serine, threonine, and tyrosine residues. O-GlcNAc is predicted to occur at five threonines and one serine. SUMOylation was predicted to occur at two lysine residues: K165 and K347; a SUMO-interacting motif was found between residues 298-302. SBK3 is also predicted undergo C-mannosylation at a singular tryptophan residue: W258.
caption: Image depicting the locations in which SBK3 is predicted to undergo phosphorylation, O-GlcNAc, SUMOylation, and C-mannosylation.
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