page_title: CXorf38 Isoform 1
section_title: Homology and Evolution
hierarchical_section_title: CXorf38 Isoform 1 / Homology and Evolution
caption_attribution_description: English: Closely related, moderately related, and distantly related orthologs of CXorf38 X1
context_page_description: Chromosome X Open Reading Frame 38 is a protein which, in humans, is encoded by the CXorf38 gene. CXorf38 appears in multiple studies regarding the escape of X chromosome inactivation.
context_section_description: The CXorf38 gene has no paralogs. Orthologs of CXorf38 have been found in some invertebrates and nearly all vertebrates. Among invertebrates sequenced to date, CXorf38 has only been found in Cnidaria and Mollusca taxonomic phyla. It has not been found in Porifera, Ctenophora, Echinodermata, Platyhelminthes, Nematoda, Annelida, or Arthropoda. The most distant ortholog of CXorf38 is the invertebrate Stylophora pistillata (Hood Coral), which is predicted to have appeared approximately 824 million years ago. Of note, the majority of invertebrate orthologs have disproportionately longer protein sequences.
  Among vertebrates sequenced to date, CXorf38 has been found in all vertebrate taxonomic orders except Pilosa and Peremelemorphia. Notably, CXorf38 is absent in all birds except 2 flightless birds sequenced to date: the emu and kiwi. Further, these bird proteins have much shorter sequences compared to other human CXorf38 orthologs.
caption: List of 20 CXorf38 Orthologs by Increasing Divergence. Rows colored with the same shade are of the same Taxonomic Order.
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