page_title: CCDC92
section_title: Orthologs
hierarchical_section_title: CCDC92 / Expression / Orthologs
caption_attribution_description: English: Adjusted amino acid changes per 100 (m) vs millions of years gives a depiction of how quickly the gene changes. Fibrinogen, a quickly changing protein, and Cytochrome C, a slowly changing protein, are given as reference.
context_page_description: CCDC92, or Limkain beta-2, is a protein which in humans is encoded by the CCDC92 gene. It is likely involved in DNA repair or reduction/oxidation reactions. The gene ubiquitously found in humans and is highly conserved across animals.
  The CCDC92 gene is located at cytogenic location 12q24.31 and is 36,576 bases long with nine exons which codes for a 331 amino-acid long protein.
context_section_description: CCDC92 has orthologs as far back as an acorn worm, which diverged from humans 750 million years ago. The most highly conserved domain is the coiled-coil domain 92, which is amino acids 23-83 in humans. This region has no known functions and is not present in any other gene.
  CCDC92 shares a 54% similarity with the protein SPPG_05228 in the fungus Spizellomyces punctatus. Spizellomyces punctatus has an 8 amino acid stretch (LKGLHSEI) which matches perfectly with the coil-coiled domain 92 of the human variant. This sequence is present in primarily proteins which are involved in reduction/oxidation reactions, and some bind to DNA.
caption: Adjusted amino acid changes per 100 (m) against millions of years since the species diverged from humans determines how quickly the protein changes. Fibrinogen and Cytochrome C are given as a reference.
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