page_title: LINE1
hierarchical_section_title: LINE1
caption_attribution_description: English: Genetic structure of murine LINE1 and SINEs. Bottom: proposed structure of L1 RNA-protein (RNP) complexes. ORF1 proteins form trimers, exhibiting RNA binding and nucleic acid chaperone activity.
context_page_description: LINE1 are class I transposable elements in the DNA of some organisms and belong to the group of long interspersed nuclear elements. L1 comprise approximately 17% of the human genome. The majority of L1 in the human genome are inactive; however, about 80-100 have retained the ability to retrotranspose, with considerable variation between individuals. These active L1s can interrupt the genome through insertions, deletions, rearrangements, and copy number variations. L1 activity has contributed to the instability and evolution of genomes, and is tightly regulated in the germline by DNA methylation, histone modifications, and piRNA. L1s can further impact genome variation by mispairing and unequal crossing-over during meiosis due to its repetitive DNA sequences.
  L1 gene products are also required by many nonautonomous Alu and SVA SINE retrotransposons. Mutations induced by L1 and its nonautonomous counterparts have been found to cause a variety of heritable and somatic diseases.
  Human L1 has been reported to have transferred to the genome of the gonorrhea bacteria.
context_section_description: LINE1 (also L1 and LINE-1) are class I transposable elements in the DNA of some organisms and belong to the group of long interspersed nuclear elements (LINEs). L1 comprise approximately 17% of the human genome. The majority of L1 in the human genome are inactive; however, about 80-100 have retained the ability to retrotranspose, with considerable variation between individuals. These active L1s can interrupt the genome through insertions, deletions, rearrangements, and copy number variations (CNV). L1 activity has contributed to the instability and evolution of genomes, and is tightly regulated in the germline by DNA methylation, histone modifications, and piRNA. L1s can further impact genome variation by mispairing and unequal crossing-over during meiosis due to its repetitive DNA sequences.
  L1 gene products are also required by many nonautonomous Alu and SVA SINE retrotransposons. Mutations induced by L1 and its nonautonomous counterparts have been found to cause a variety of heritable and somatic diseases.
  Human L1 has been reported to have transferred to the genome of the gonorrhea bacteria.
caption: Genetic structure of murine LINE1 and SINEs. Bottom: proposed structure of L1 RNA-protein (RNP) complexes. ORF1 proteins form trimers, exhibiting RNA binding and nucleic acid chaperone activity.
exif: {}