page_title: Asparagine synthase (glutamine-hydrolysing)
hierarchical_section_title: Asparagine synthase (glutamine-hydrolysing)
caption_attribution_description: English: Asparagine synthetase B dimer + 2 AMP (green-red) + 2 glutamine (l.blue-red) + 8 UO2 (d.green) + 2 Cl (yellow), E.Coli
context_page_description: Asparagine synthase (glutamine-hydrolysing) is an enzyme with systematic name L-aspartate:L-glutamine amido-ligase. This enzyme catalyses the following chemical reaction
  ATP + L-aspartate + L-glutamine + H₂O AMP + diphosphate + L-asparagine + L-glutamate
  L-glutamine + H₂O L-glutamate + NH₃
  ATP + L-aspartate + NH₃ AMP + diphosphate + L-asparagine
  The enzyme from Escherichia coli has two active sites6].
context_section_description: Asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4, asparagine synthetase (glutamine-hydrolysing), glutamine-dependent asparagine synthetase, asparagine synthetase B, AS, AS-B) is an enzyme with systematic name L-aspartate:L-glutamine amido-ligase (AMP-forming). This enzyme catalyses the following chemical reaction
  ATP + L-aspartate + L-glutamine + H₂O  AMP + diphosphate + L-asparagine + L-glutamate (overall reaction)
  (1a) L-glutamine + H₂O  L-glutamate + NH₃
  (1b) ATP + L-aspartate + NH₃  AMP + diphosphate + L-asparagine
  The enzyme from Escherichia coli has two active sites6].
caption: Asparagine synthetase B dimer, E.Coli
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