page_title: Methylglyoxal
section_title: Biochemical function
hierarchical_section_title: Methylglyoxal / Biochemistry / Biochemical function
caption_attribution_description: English: Methylglyoxal-derived pyrimidine and imidazolone
context_page_description: Methylglyoxal is the organic compound with the formula CH₃CCHO. It is a reduced derivative of pyruvic acid. It is a reactive compound that is implicated in the biology of diabetes. Methylglyoxal is produced industrially by degradation of carbohydrates using overexpressed methylglyoxal synthase.
context_section_description: Methylglyoxal is involved in the formation of advanced glycation endproducts (AGEs). In this process, methylglyoxal reacts with free amino groups of lysine and arginine and with thiol groups of cysteine forming AGEs. Histones are also heavily susceptible to modification by methylglyoxal and these modifications are elevated in breast cancer.
caption: AGEs derived from the action of methylglyoxal on arginine.[11]
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