page_title: Framework region
hierarchical_section_title: Framework region
caption_attribution_description: English: The universal structure of antibody includes the constant regions part of the fragment crystallizable(Fc) region of the antibody(shown in dark blue). It also includes the fragment antigen binding which is composed of one heavy and one light chain(shown as L for light and V for heavy). Each heavy and light chain is composed of one variable region and one constant region(shown as V or C). The variable regions are composed of 7 amino acid segments; three of which are hypervariable regions or CDR(yellow) and four of which are FR(shown in green for heavy chains and pink for light chains).
context_page_description: In molecular biology, a framework region is a subdivision of the variable region of the antibody. The variable region is composed of seven amino acid regions, four of which are framework regions and three of which are hypervariable regions. The framework region makes up about 85% of the variable region. Located on the tips of the Y-shaped molecule, the framework regions are responsible for acting as a scaffold for the complementarity determining regions, also referred to as hypervariable regions, of the Fab. These CDRs are in direct contact with the antigen and are involved in binding antigen, while the framework regions support the binding of the CDR to the antigen and aid in maintaining the overall structure of the four variable domains on the antibody. To increase its stability, the framework region has less variability in its amino acid sequences compared to the CDR.
context_section_description: In molecular biology, a framework region is a subdivision of the variable region (Fab) of the antibody. The variable region is composed of seven amino acid regions, four of which are framework regions and three of which are hypervariable regions.  The framework region makes up about 85% of the variable region. Located on the tips of the Y-shaped molecule, the framework regions are responsible for acting as a scaffold for the  complementarity determining regions (CDR), also referred to as hypervariable regions, of the Fab. These CDRs are in direct contact with the antigen and are involved in binding antigen, while the framework regions support the binding of the CDR to the antigen and aid in maintaining the overall structure of the four variable domains on the antibody. To increase its stability, the framework region has less variability in its amino acid sequences compared to the CDR.
caption: The universal structure of antibody includes the constant regions part of the fragment crystallizable(Fc) region of the antbody (shown in dark blue). It also includes the fragment antigen binding which is composed of one heavy and one light chain (shown as L for light and H for heavy). Each heavy and light chain is composed of one variable region and one constant region (shown as V or C). The variable regions are composed of 7 amino acid segments; three of which are hypervariable regions or CDR (yellow) and four of which are FR(shown in green for heavy chains and pink for light chains).
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