page_title: EHD3
section_title: Functions
hierarchical_section_title: EHD3 / Functions
caption_attribution_description: English: EHD3 can be mainly found in human heart and brain, as well as kidney, ovary and liver.
context_page_description: Eps15 homology domain-containing protein 3, abbreviated as EDH3 and also known as PAST3, is a protein encoded by the EHD3 gene. It has been observed in humans, mice and rats. It belongs to the EHD protein family, a group of four membrane remodeling proteins related to the Dynamin superfamily of large GTPases. Although the four of them are 70-80% amino acid identical, they all have different locations. Its main function is related to endocytic transport.
context_section_description: The EH domain is a common motif in a family of proteins involved in endocytic trafficking. This family of four paralogs (EHD1-EHD4) has been implicated in receptor intracellular trafficking, particularly in internalization and recycling to the plasma membrane. The list of functions of EHD proteins is just starting to be populated.
  EHD3 is a moonlighting protein, which means it can perform different functions depending on the tissue where the protein is located. The main functions are the following:
  To take part in endocytic transport. The EHD-family proteins have been seen to have a direct relation with endocytic transport in the cell. EHD1 (the closest paralog of EHD3) is in charge of enabling membrane recycling by controlling the way out of internalized molecules from the ERC to the plasma membrane. It has also been found that these EHD proteins bind to the Rab11-effector Rab11-FIP2 via EH-NPF interactions. These associations are affected by their ability to bind nucleotides. The role of EHD1 bonded to the Rab11-effector is clear (stated above), while there has not been found a clear relation between EHD3 and Rab11-FIP2. But when the EHD3 protein underwent a knockdown, the delivery of internalized transferrin and early endosomal proteins to the ERC was prevented, and even the subcellular location of Rab11-FIP2 changed. Therefore, a coordinated role for EHD proteins and Rab11-FIP2 has been found in mediating endocytic recycling and concretely for EHD3, early endosome to ERC transport.
  To control the membrane reorganization upon ATP hydrolysis.
  To induce phosphatidic acid membrane tubulation activity.
  To recycle the D1 dopamine receptor.
caption: EHD3 can be mainly found in human heart and brain, as well as kidney, ovary and liver.[15]
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