page_title: DUTP diphosphatase
hierarchical_section_title: DUTP diphosphatase
caption_attribution_description: English: Cartoon representation of the molecular structure of protein registered with 1w2y code. Deutsch: Grafik des Molekularstruktur von jenem Protein, das mit 1w2y code registriert ist. Plattdüütsch: Grafik, de de Molekularstruktur von dat Protein wiest, dat mit’n Kood 1w2y registreert is.
context_page_description: In enzymology, a dUTP diphosphatase is an enzyme that catalyzes the chemical reaction
  dUTP + H₂O dUMP + diphosphate
  Thus, the two substrates of this enzyme are dUTP and H₂O, whereas its two products are dUMP and diphosphate.
  This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is dUTP nucleotidohydrolase. Other names in common use include deoxyuridine-triphosphatase, dUTPase, dUTP pyrophosphatase, desoxyuridine 5'-triphosphate nucleotidohydrolase, and desoxyuridine 5'-triphosphatase. This enzyme participates in pyrimidine metabolism.
  This enzyme has a dual function: on one hand, it removes dUTP from the deoxynucleotide pool, which reduces the probability of this base being incorporated into DNA by DNA polymerases, while on the other hand, it produces the dTTP precursor dUMP. Lack or inhibition of dUTPase action leads to harmful perturbations in the nucleotide pool resulting in increased uracil content of DNA that activates a hyperactive futile cycle of DNA repair.
context_section_description: In enzymology, a dUTP diphosphatase (EC 3.6.1.23) is an enzyme that catalyzes the chemical reaction
  dUTP + H₂O  dUMP + diphosphate
  Thus, the two substrates of this enzyme are dUTP and H₂O, whereas its two products are dUMP and diphosphate.
  This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides.  The systematic name of this enzyme class is dUTP nucleotidohydrolase. Other names in common use include deoxyuridine-triphosphatase, dUTPase, dUTP pyrophosphatase, desoxyuridine 5'-triphosphate nucleotidohydrolase, and desoxyuridine 5'-triphosphatase.  This enzyme participates in pyrimidine metabolism.
  This enzyme has a dual function: on one hand, it removes dUTP from the deoxynucleotide pool, which reduces the probability of this base being incorporated into DNA by DNA polymerases, while on the other hand, it produces the dTTP precursor dUMP. Lack or inhibition of dUTPase action leads to harmful perturbations in the nucleotide pool resulting in increased uracil content of DNA that activates a hyperactive futile cycle of DNA repair.
caption: the crystal structure of a complex of campylobacter jejuni dutpase with substrate analogue dupnhp
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