page_title: Procyclidine
section_title: Synthesis
hierarchical_section_title: Procyclidine / Synthesis
caption_attribution_description: English: DE patent 1084734 US patent 2826590 doi:10.1039/JR9510000052.
context_page_description: Procyclidine is an anticholinergic drug principally used for the treatment of drug-induced parkinsonism, akathisia and acute dystonia; Parkinson disease; and idiopathic or secondary dystonia.
context_section_description: Procyclidine, 1-cyclohexyl-1-phenyl-3-pyrrolidinopropan-1-ol, is synthesized in exactly the same manner as was seen for trihexyphenidyl, except this time the linear synthesis begins with the preparation of 3-(1-pyrrolidino)propiophenone.
  In an interesting variation, the ketone is first reacted with phenylmagnesium bromide. Catalytic hydrogenation of the carbinol thus obtained can be stopped after the reduction of only one aromatic ring.
caption: Procyclidine synthesis: DE 1084734  U.S. Patent 2,826,590
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