page_title: Perilipin-5
section_title: Function
hierarchical_section_title: Perilipin-5 / Function
caption_attribution_description: English: The 3D structure of Perilipin 5 on humans.
context_page_description: Perilipin 5, also known as Oxpatperilipin 5 or PLIN5, is a protein that belongs to perilipin family. This protein group has been shown to be responsible for lipid droplet's biogenesis, structure and degradation. In particular, Perilipin 5 is a lipid droplet-associated protein whose function is to keep the balance between lipolysis and lipogenesis, as well as maintaining lipid droplet homeostasis. For example, in oxidative tissues, muscular tissues and cardiac tissues, PLIN5 promotes association between lipid droplets and mitochondria.
  Inside the cell, PLIN5 can be found in multiple intracellular structures including lipid droplets, endoplasmic reticulum, mitochondria, and the cytosol. The wrong expression of this protein has been proven to be related with diseases such as skeletal muscle diseases, liver diseases or carcinogenesis.
context_section_description: Perilipin 5 is a protein often found in the adipose tissue, especially in those with high oxidative stress, including the heart, liver, skeletal muscle and brown adipose tissue (BAT). The perilipin family contributes to the creation of lipid droplets and it also plays a pivotal role in determining what the lipid droplet's function is within the cell. In addition, perilipin 5 regulates the activation of hepatic stellate cell, implicated in fibrosis, which is the creation of new tissue to repair the one damaged.
caption: The 3D structure of Perilipin 5 on humans. It is 66.122% identical to PLIN5 on rats, with 80 identical spots.
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