page_title: Steroidogenic enzyme
section_title: List of steroidogenic enzymes
hierarchical_section_title: Steroidogenic enzyme / List of steroidogenic enzymes
context_page_description: Steroidogenic enzymes are enzymes that are involved in steroidogenesis and steroid biosynthesis. They are responsible for the biosynthesis of the steroid hormones, including sex steroids and corticosteroids, as well as neurosteroids, from cholesterol. Steroidogenic enzymes are most highly expressed in classical steroidogenic tissues, such as the testis, ovary, and adrenal cortex, but are also present in other tissues in the body.
context_section_description: Steroid desmolases
  Cholesterol side-chain cleavage enzyme (20,22-desmolase) – steroid synthesis
  17,20-Lyase (17,20-desmolase) – androgen synthesis
  Steroid hydroxylases
  11β-Hydroxylase – corticosteroid synthesis
  17α-Hydroxylase – androgen and glucocorticoid synthesis
  18-Hydroxylase (aldosterone synthase) – mineralocorticoid synthesis
  21-Hydroxylase – corticosteroid synthesis
  Cytochrome P450 (CYP1, 2, 3) – estrogen metabolism
  Hydroxysteroid dehydrogenases (and ketosteroid reductases)
  3α-Hydroxysteroid dehydrogenase – androgen, progestogen, and neurosteroid synthesis and metabolism
  3β-Hydroxysteroid dehydrogenase/Δ⁵⁻⁴-isomerase (1, 2) – androgen, progestogen, and neurosteroid synthesis
  11β-Hydroxysteroid dehydrogenase (1, 2) – corticosteroid synthesis and metabolism
  17β-Hydroxysteroid dehydrogenase (1–15) – androgen, estrogen, and progestogen synthesis and metabolism
  20α-Hydroxysteroid dehydrogenase – progestogen synthesis and metabolism
  20β-Hydroxysteroid dehydrogenase – progestogen synthesis and metabolism
  Steroid reductases
  5α-Reductase (1, 2, 3) – androgen and neurosteroid synthesis, progestogen metabolism
  5β-Reductase – androgen and progestogen metabolism, neurosteroid synthesis
  Conjugation (and deconjugation)
  Glucuronosyltransferase (UGT2Bs) – steroid metabolism
  Glucuronidase (β-glucuronidase) – steroid synthesis
  Steroid sulfotransferase (SULT1A1, 1E1, 2A1, 2B1a, 2B1b) – steroid metabolism, neurosteroid synthesis
  Steroid sulfatase – steroid synthesis, neurosteroid metabolism
  Others
  Aromatase (estrogen synthetase) – estrogen synthesis
caption: Steroid numbering.
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