page_title: Captopril
section_title: Medical uses
hierarchical_section_title: Captopril / Medical uses
caption_attribution_description: English: Drosophila Angiotensin Converting Enzyme in complex with Captopril
context_page_description: Captopril, sold under the brand name Capoten among others, is an angiotensin-converting enzyme inhibitor used for the treatment of hypertension and some types of congestive heart failure.
  It was patented in 1976 and approved for medical use in 1980.
context_section_description: Captopril's main uses are based on its vasodilation and inhibition of some renal function activities.  These benefits are most clearly seen in:
  1) Hypertension
  2) Cardiac conditions such as congestive heart failure and after myocardial infarction
  3) Preservation of kidney function in diabetic nephropathy.
  Additionally, it has shown mood-elevating properties in some patients. This is consistent with the observation that animal screening models indicate putative antidepressant activity for this compound, although one study has been negative. Formal clinical trials in depressed patients have not been reported.
  It has also been investigated for use in the treatment of cancer. Captopril stereoisomers were also reported to inhibit some metallo-β-lactamases.
caption: Drosophila ACE in complex with captopril (purple), PDB entry 2x8z[2]
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