page_title: Affilin
section_title: Based on ubiquitin
hierarchical_section_title: Affilin / Structure / Based on ubiquitin
caption_attribution_description: English: Cartoon representation of the molecular structure of protein registered with 1ubq code. Deutsch: Grafik des Molekularstruktur von jenem Protein, das mit 1ubq code registriert ist. Plattdüütsch: Grafik, de de Molekularstruktur von dat Protein wiest, dat mit’n Kood 1ubq registreert is.
context_page_description: Affilins are artificial proteins designed to selectively bind antigens. Affilin proteins are structurally derived from human ubiquitin. Affilin proteins are constructed by modification of surface-exposed amino acids of these proteins and isolated by display techniques such as phage display and screening. They resemble antibodies in their affinity and specificity to antigens but not in structure, which makes them a type of antibody mimetic. Affilin was developed by Scil Proteins GmbH as potential new biopharmaceutical drugs, diagnostics and affinity ligands.
context_section_description: Ubiquitin, as the name suggests, is a highly conserved protein occurring ubiquitously in eucaryotes. It consists of 76 amino acids in three and a half alpha helix windings and five strands constituting a beta sheet. For example, the eight surface-exposed exchangeable amino acids 2, 4, 6, 62, 63, 64, 65, and 66 are located at the beginning of the first N-terminal beta strand (2, 4, 6), at the nearby beginning of the C-terminal strand and the loop leading up to it (63–66). The resulting Affilin proteins are about 10 kDa in mass.
caption: Human ubiquitin, wild-type (PDB: 1UBQ​). The N-terminal beta strand is the second from top, pointing right; the C-terminal strand is the one in front, pointing right and downwards. The exchangeable amino acids are located at the top left.
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