page_title: GAL4/UAS system
hierarchical_section_title: GAL4/UAS system
caption_attribution_description: Deutsch: Schematischer Aufbau eines Gal4/UAS-Systems: Die Expression von GAL4 unter einem speziellen Promotor führt durch die Bindung an die UAS-Sequenz zur Aktivierung beliebiger Gene (z.B. GFP).English: Schematic structure of a Gal4/UAS system; Expression of GAL4 under a particular promoter will result in activation of any genes (e.g., GFP) by binding to the UAS sequence.
context_page_description: The GAL4-UAS system is a biochemical method used to study gene expression and function in organisms such as the fruit fly. It has also been adapted to study receptor chemical-binding functions in vitro in cell culture. It was developed by Hitoshi Kakidani and Mark Ptashne, and Nicholas Webster and Pierre Chambon in 1988, then adapted by Andrea Brand and Norbert Perrimon in 1993 and is considered a powerful technique for studying the expression of genes. The system has two parts: the Gal4 gene, encoding the yeast transcription activator protein Gal4, and the UAS, an enhancer to which GAL4 specifically binds to activate gene transcription.
context_section_description: The GAL4-UAS system is a biochemical method used to study gene expression and function in organisms such as the fruit fly. It has also been adapted to study receptor chemical-binding functions in vitro in cell culture. It was developed by Hitoshi Kakidani and Mark Ptashne, and Nicholas Webster and Pierre Chambon in 1988, then adapted by Andrea Brand and Norbert Perrimon in 1993 and is considered a powerful technique for studying the expression of genes. The system has two parts: the Gal4 gene, encoding the yeast transcription activator protein Gal4, and the UAS (Upstream Activation Sequence), an enhancer to which GAL4 specifically binds to activate gene transcription.
caption: An example GAL4-UAS system, with GAL4 lines and UAS reporter lines.
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