page_title: Oligosaccharyltransferase
hierarchical_section_title: Oligosaccharyltransferase
caption_attribution_description: English: Structure of the yeast oligosaccharyltransferase complex based on the 6ezn PDB coordinates.
context_page_description: Oligosaccharyltransferase or OST is a membrane protein complex that transfers a 14-sugar oligosaccharide from dolichol to nascent protein. It is a type of glycosyltransferase. The sugar Glc₃Man₉GlcNAc₂ is attached to an asparagine residue in the sequence Asn-X-Ser or Asn-X-Thr where X is any amino acid except proline. This sequence is called a glycosylation sequon. The reaction catalyzed by OST is the central step in the N-linked glycosylation pathway.
context_section_description: Oligosaccharyltransferase or OST (EC 2.4.1.119) is a membrane protein complex that transfers a 14-sugar oligosaccharide from dolichol to nascent protein.  It is a type of glycosyltransferase. The sugar Glc₃Man₉GlcNAc₂ (where Glc=Glucose, Man=Mannose, and GlcNAc=N-acetylglucosamine) is attached to an asparagine (Asn) residue in the sequence Asn-X-Ser or Asn-X-Thr where X is any amino acid except proline.  This sequence is called a glycosylation sequon. The reaction catalyzed by OST is the central step in the N-linked glycosylation pathway.
caption: Structure of yeast OST [1]
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