page_title: Phosphoramidite ligand
section_title: 1,4-addition
hierarchical_section_title: Phosphoramidite ligand / Reactions using phosphoramidite ligands / 1,4-addition
caption_attribution_description: English: Reactions of phosphoramidite ligand
context_page_description: A phosphoramidite ligand is a chiral monodentate phosphine ligand, widely used for enantioselective synthesis. They were invented by Dutch chemist Ben Feringa. The introduction of phosphoramidite ligands challenged the notion that high flexibility in the metal–ligand complex is detrimental for high stereo control.
context_section_description: A dramatic increase in the enantioselectivity of the addition reactions was observed when a chiral amine moiety was incorporated in these phosphoramidite ligands. Excellent yields (up to 95 %) and ee values exceeding 98 % ee were achieved in the addition to cyclochexenone in the presence of the bis(1-phenylethyl)amine derived ligand.  In addition to the organozinc nucleophiles used by Feringa, the 1,4-addition to enones has been shown by Woodward to work with organoaluminum nucleophiles.
caption: Reactions of phosphoramidite ligand
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