page_title: Protease inhibitor (biology)
section_title: Inhibitor I34
hierarchical_section_title: Protease inhibitor (biology) / Families / Inhibitor I34
caption_attribution_description: English: Cartoon representation of the molecular structure of protein registered with 1dp5 code. Deutsch: Grafik des Molekularstruktur von jenem Protein, das mit 1dp5 code registriert ist. Plattdüütsch: Grafik, de de Molekularstruktur von dat Protein wiest, dat mit’n Kood 1dp5 registreert is.
context_page_description: In biology and biochemistry, protease inhibitors, or antiproteases, are molecules that inhibit the function of proteases. Many naturally occurring protease inhibitors are proteins.
  In medicine, protease inhibitor is often used interchangeably with alpha 1-antitrypsin. A1AT is indeed the protease inhibitor most often involved in disease, namely in alpha-1 antitrypsin deficiency.
context_section_description: The saccharopepsin inhibitor I34 is highly specific for the aspartic peptidase saccharopepsin. In the absence of saccharopepsin it is largely unstructured, but in its presence, the inhibitor undergoes a conformational change forming an almost perfect alpha-helix from Asn2 to Met32 in the active site cleft of the peptidase.
caption: the structure of proteinase a complexed with an ia3 mutant inhibitor
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