page_title: Umbellulone
section_title: Structure and reactivity
hierarchical_section_title: Umbellulone / Structure and reactivity
caption_attribution_description: English: Cysteamine
context_page_description: Umbellulone is a headache-inducing monoterpene ketone found in the leaves of the tree Umbellularia californica, sometimes known as the "headache tree".
  It is hypothesized to cause headaches by influencing the trigeminovascular system via TRPA1.
context_section_description: Umbellulone is a monoterpene ketone that is found in the leaves of Umbellularia californica. The formula of umbellulone is C₁₀H₁₄O, containing a cyclopropane and cyclopentane ring. There is only one isomer of umbellulone known. Umbellulone is a lipophilic liquid (oil) at room temperature. The boiling point of umbellulone is 220 °C and the vapor pressure is 0.159 mm/Hg. Umbellulone has a high-affinity binding for thiols. The molecule is reactive with most of the thiols, but not with all. The reaction between the thiol cysteamine and umbellulone, is given in figure 3. A European registered medicine called Cystagon® or Procysbi® contains cysteamine, which can interact with umbellulone.
caption: Figure 3: Reaction between cysteamine and umbellulone.
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