page_title: DNA laddering
hierarchical_section_title: DNA laddering
caption_attribution_description: English: Apoptotic DNA laddering visualised in an agarose gel by ethidium bromide staining. DNA was extracted from the rat hepatoma cell line H4IIE. Left lane: Cells were treated with 1 mM of the apoptosis-inducing substance paraquat for 24 h. Middle lane: 1 kb Marker (GeneRuler, Fermentas). Right lane: DNA from untreated cells (control).
context_page_description: DNA laddering is a feature that can be observed when DNA fragments, resulting from apoptotic DNA fragmentation, are visualized after separation by gel electrophoresis. It was first described in 1980 by Andrew Wyllie at the University of Edinburgh Medical School. DNA fragments can also be detected in cells that underwent necrosis, but when these DNA fragments after separation are subjected to gel electrophoresis no clear "ladder" pattern is apparent.
context_section_description: DNA laddering is a feature that can be observed when DNA fragments, resulting from apoptotic DNA fragmentation, are visualized after separation by gel electrophoresis. It was first described in 1980 by Andrew Wyllie at the University of Edinburgh Medical School. DNA fragments can also be detected in cells that underwent necrosis, but when these DNA fragments after separation are subjected to gel electrophoresis no clear "ladder" pattern is apparent.
caption: DNA laddering (left) visualised in an agarose gel by ethidium bromide staining. A 1 kb marker (middle) and control DNA (right) are included.
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