page_title: NOD2
section_title: Structure
hierarchical_section_title: NOD2 / Structure
caption_attribution_description: English: NOD2 protein model consisting CARD, LRR and NBD domains
context_page_description: Nucleotide-binding oligomerization domain-containing protein 2, also known as caspase recruitment domain-containing protein 15 or inflammatory bowel disease protein 1, is a protein that in humans is encoded by the NOD2 gene located on chromosome 16. NOD2 plays an important role in the immune system. It recognizes bacterial molecules and stimulates an immune reaction.
  NOD2 is an intracellular pattern recognition receptor, which is similar in structure to resistant proteins of plants and recognizes molecules containing the specific structure called muramyl dipeptide that is found in certain bacteria.
context_section_description: The C-terminal portion of the protein contains a leucine-rich repeat domain that is known to play a role in protein–protein interactions. The middle part of the protein is characterized by a NOD domain involved in protein self-oligomerization. The N-terminal portion contains two CARD domains known to play a role in apoptosis and NF-κB activation pathways.
caption: NOD2 protein model consisting two N-terminal CARD domains (red) connected via helical linker (blue) with central NOD  domain (green). At C-terminus LRR domain (cyan) is located[9]
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