page_title: Aphthovirus
section_title: Replication
hierarchical_section_title: Aphthovirus / Replication
context_page_description: Aphthovirus is a viral genus of the family Picornaviridae. Aphthoviruses infect split-hooved animals, and include the causative agent of foot-and-mouth disease. Foot-and-mouth disease virus is the prototypic member of the genus Aphthovirus. There are seven FMDV serotypes: A, O, C, SAT 1, SAT 2, SAT 3 and Asia 1, and four non-FMDV serotypes belonging to three additional species Bovine rhinitis A virus, Bovine rhinitis B virus and Equine rhinitis A virus.
context_section_description: Aphthoviruses replicate in a similar fashion to all picornaviruses. Replication is cytoplasmic and initially involves attachment of the exogenous virus to the cell membrane. Attachment to the membrane and subsequent entry into the cell is mediated by a membrane receptor. After genome replication within the cytoplasm, virion assembly occurs and new virus particles aggregate within the cell. Release of virus particles is mediated by cell lysis.
caption: Replication cycle of type species Foot-and-mouth disease virus
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