page_title: Proton-sensing G protein-coupled receptors
hierarchical_section_title: Proton-sensing G protein-coupled receptors
caption_attribution_description: English: Production of cAMP in response to activation of TDAG8 G protein-coupled receptor by low pH.
context_page_description: Proton-sensing G protein-coupled receptors are transmembrane receptors which sense acidic pH and include GPR132, GPR4, GPR68 and GPR65. These G protein-coupled receptors are activated when extracellular pH falls into the range of 6.4-6.8. The functional role of the low pH sensitivity of the proton-sensing G protein-coupled receptors is being studied in several tissues where cells respond to conditions of low pH including bone and inflamed tissues. The four known proton-sensing G protein-coupled receptors are Class A receptors in subfamily A15.
context_section_description: Proton-sensing G protein-coupled receptors are transmembrane receptors which sense acidic pH and include GPR132 (G2A), GPR4, GPR68 (OGR1) and GPR65 (TDAG8). These G protein-coupled receptors are activated when extracellular pH falls into the range of 6.4-6.8 (typical values are above 7.0). The functional role of the low pH sensitivity of the proton-sensing G protein-coupled receptors is being studied in several tissues where cells respond to conditions of low pH including bone and inflamed tissues. The four known proton-sensing G protein-coupled receptors are Class A receptors in subfamily A15.
caption: Production of cAMP in response to activation of TDAG8 G protein-coupled receptor by low pH. Data from Wang et al., "TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor".[1]
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