page_title: Norepinephrine transporter
section_title: Structure
hierarchical_section_title: Norepinephrine transporter / Structure
caption_attribution_description: English: Simplified structure of the norepinephrine transporter protein. The protein is 617 amino acids long and consists of 12 transmembrane domains. Not to scale.
context_page_description: The norepinephrine transporter, also known as noradrenaline transporter and solute carrier family 6 member 2, is a protein that in humans is encoded by the SLC6A2 gene.
  NET is a monoamine transporter and is responsible for the sodium-chloride-dependent reuptake of extracellular norepinephrine, which is also known as noradrenaline. NET can also reuptake extracellular dopamine. The reuptake of these two neurotransmitters is essential in regulating concentrations in the synaptic cleft. NETs, along with the other monoamine transporters, are the targets of many antidepressants and recreational drugs. In addition, an overabundance of NET is associated with ADHD. There is evidence that single-nucleotide polymorphisms in the NET gene may be an underlying factor in some of these disorders.
context_section_description: The norepinephrine transporter is composed of 12 transmembrane domains (TMDs). The intracellular portion contains an amino (-NH
  ₂) group and carboxyl (-COOH) group. In addition, there is a large extracellular loop located between TMD 3 and 4. The protein is composed of 617 amino acids.
caption: Simplified structure of the norepinephrine transporter protein.
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