page_title: Lysergic acid diethylamide
section_title: Dosage
hierarchical_section_title: Lysergic acid diethylamide / Chemistry / Dosage
caption_attribution_description: English: 10 hits of White On White (WOW) LSD.
context_page_description: Lysergic acid diethylamide, also known colloquially as acid, is a hallucinogenic drug. Effects typically include altered thoughts, feelings, and awareness of one's surroundings. Many users see or hear things that do not exist. Dilated pupils, increased blood pressure, and increased body temperature are typical. Effects typically begin within half an hour and can last for up to 12 hours. It is used mainly as a recreational drug or for spiritual reasons.
  LSD does not appear to be addictive, although tolerance may occur with use of increasing doses. Adverse psychiatric reactions are possible, such as anxiety, paranoia, and delusions. Distressing flashbacks might occur in spite of no further use, a condition called hallucinogen persisting perception disorder. Death as a result of LSD overdose is virtually unknown; on extremely rare occasions death can be the result of accidents or reckless behavior. The effects of LSD are believed to occur as a result of alterations in the serotonin system. As little as 20 micrograms can produce a noticeable effect. In pure form, LSD is clear or white in color, has no smell, and is crystalline. It breaks down with exposure to ultraviolet light.
context_section_description: A single dose of LSD may be between 40 and 500 micrograms—an amount roughly equal to one-tenth the mass of a grain of sand. Threshold effects can be felt with as little as 25 micrograms of LSD. Dosages of LSD are measured in micrograms (µg), or millionths of a gram. By comparison, dosages of most drugs, both recreational and medicinal, are measured in milligrams (mg), or thousandths of a gram. For example, an active dose of mescaline, roughly 0.2 to 0.5 g, has effects comparable to 100 µg or less of LSD.
  In the mid-1960s, the most important black market LSD manufacturer (Owsley Stanley) distributed acid at a standard concentration of 270 µg, while street samples of the 1970s contained 30 to 300 µg. By the 1980s, the amount had reduced to between 100 and 125 µg, dropping more in the 1990s to the 20–80 µg range,  and even more in the 2000s (decade).
caption: White on White blotters (WoW) for sublingual administration
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