page_title: A value
section_title: Approximating intramolecular force strength using A-Values
hierarchical_section_title: A value / Applications / Approximating intramolecular force strength using A-Values
caption_attribution_description: English: The chair flip and hydrogen bonding available in a trisubstituted ring
context_page_description: A-Values are numerical values used in the determination of the most stable orientation of atoms in a molecule, as well as a general representation of steric bulk. A-values are derived from energy measurements of the different cyclohexane conformations of a monosubstituted cyclohexane chemical.
  Substituents on a cyclohexane ring prefer to reside in the equatorial position to the axial. The difference in Gibbs free energy between the higher energy conformation and the lower energy conformation is the A-value for that particular substituent.
context_section_description: Using the A-Values of the hydroxyl and isopropyl subunit, the energetic value of a favorable intramolecular hydrogen bond can be calculated.
caption: Possible chair conformations and the favorable hydrogen bond available in the conformation where both hydroxyl substituents are equatorial
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