page_title: Cellular dewetting
hierarchical_section_title: Cellular dewetting
caption_attribution_description: English: Snapshot images taken from a video showing the nucleation and growth of a TEM in an endothelial cell intoxicated with C3 exoenzyme from Clostridium botulinum for 24 hours, Bar = 10μm. For the dynamic see Video at http://movie.rupress.org/video/10.1083/jcb.200509009/video-1
context_page_description: Cellular dewetting refers to the process of nucleation and enlargement of transendothelial cell macroaperture tunnels in endothelial cells. This phenomenon is analogous to the nucleation and growth of dry patches in viscous liquids spreading on a non-wettable substrate. Cellular dewetting is triggered by several protein toxins from pathogenic bacteria, notably the EDIN-like factors from Staphylococcus aureus and from Clostridium botulinum, as well as edema toxin from Bacillus anthracis. TEMs form in response to the rupture of cytoskeleton physical connections through the cytoplasm due to inhibition of the RhoA/ROCK pathway or to induction of the flux of cyclic-AMP broad signaling molecule.
context_section_description: Cellular dewetting refers to the process of nucleation and enlargement of transendothelial cell macroaperture (TEM) tunnels in endothelial cells (Figure 1). This phenomenon is analogous to the nucleation and growth of dry patches in viscous liquids spreading on a non-wettable substrate (Figure 2). Cellular dewetting is triggered by several protein toxins from pathogenic bacteria, notably the EDIN-like factors from Staphylococcus aureus and from Clostridium botulinum, as well as edema toxin from Bacillus anthracis. TEMs form in response to the rupture of cytoskeleton physical connections through the cytoplasm due to inhibition of the RhoA/ROCK pathway or to induction of the flux of cyclic-AMP (cAMP) broad signaling molecule.
caption: Figure 1. Snapshot images taken from a video showing the nucleation and growth of a TEM in an endothelial cell intoxicated with C3 exoenzyme from Clostridium botulinum for 24 hours, Bar = 10 μm. For the dynamics see Video.
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