page_title: LCHN
section_title: Neuronal insult
hierarchical_section_title: LCHN / Predicted function / Neuronal insult
caption_attribution_description: English: Brain development
context_page_description: LCHN is a protein that in humans is encoded by the KIAA1147 gene located on chromosome 7. It is likely part of the tripartite DENN domain family of proteins that often function as Rab-GEFs to regulate vesicular trafficking. Both the mRNA and protein have been shown to be upregulated following ischemic stroke, and to be produced at altered levels in patients with FTD-ALS, however the gene's contribution to these states is not well understood.
context_section_description: LCHN expression has been reported to be unregulated following ischemic stroke, chronic alcoholism, and cell culture responses of immature and mature dendrites to prolonged hypoxia. Additionally, decreased expression as a result of CpG methylation has been implicated to be pathogenic in patients with FTD-ALS. Within the predicted promoter of KIAA1147, there are predicted binding sites for hypoxia response elements that would accompany ischemic stroke,  heat shock proteins, factors related to the glucocorticoid mediated stress response, and cAMP responsive factors related to the ER stress response. Due to the reported evidence of LCHN upregulation following ischemic stroke, which often results in neuronal damage or death, as well presence of several binding sites for factors induced by rapid trauma to the brain, it is likely that KIAA1147 plays a role in the brain’s response to sudden stress and injury.
caption: LCHN is localized to the developing mouse brain
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