page_title: Ramanujan Hegde
section_title: Research and career
hierarchical_section_title: Ramanujan Hegde / Research and career
caption_attribution_description: English: Title Hegde, Ramanujan Description Portrait Topics/Categories National Cancer Institute, People Type B&amp;W, Photo Source National Cancer Institute
context_page_description: Ramanujan Shankar Hegde FRS is a group leader in the Medical Research Council Laboratory of Molecular Biology at the University of Cambridge.
context_section_description: Hegde's research investigates how proteins are localised correctly inside cells, and how errors during protein maturation are recognised and disposed. These processes are important because the accumulation of abnormal proteins is disruptive to cell function, and underlies numerous diseases.
  His laboratory have discovered a widely conserved protein targeting pathway needed by a subset of proteins to reach their correct membrane-embedded destination. Their studies of such protein targeting pathways are revealing how membrane proteins are accurately recognised by the machinery responsible for their proper localisation and insertion. Hegde's work has also shown that even modest failures of individual proteins to reach their correct cellular location can lead to neurodegeneration, and that cells have specialised pathways to identify these wayward proteins and target them for destruction.
  As of 2016, according to Google Scholar his most cited research include papers published in Science, Nature, and Cell. His research has been funded by the Medical Research Council.
caption: Ramanujan Hegde in 2001
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