page_title: Subventricular zone
hierarchical_section_title: Subventricular zone
caption_attribution_description: English: The anatomy of the neurogenic subventricular zone in the adult rodent and human brain. (A) Sagittal view of a rodent brain showing the sites of neurogenesis in the subventricular zone/olfactory bulb (SVZ/OB) system. (B) Schematic drawing of the composition and cytoarchitecture of the adult rodent SVZ. (C) Coronal view of the adult human brain showing the basal ganglia and lateral ventricles. (D) Schematic drawing depicting the cellular composition and cytoarchitecture of the adult human SVZ, consisting of four layers: Layer I – ependymal cell layer (green), Layer II – hypocellular gap, Layer III – astrocytic ribbon, containing astrocytes and migrating neuroblasts, Layer IV – transitional zone, containing oligodendrocytes and separating the SVZ from the striatum rich in neurons. RMS: rostral migratory stream; DG: dentate gyrus; LV: lateral ventricle. Arias-Carrión International Archives of Medicine 2008 1:2 doi:10.1186/1755-7682-1-2
context_page_description: The subventricular zone is a region situated on the outside wall of each lateral ventricle of the vertebrate brain. It is present in both the embryonic and adult brain. In embryonic life, the SVZ refers to a secondary proliferative zone containing neural progenitor cells, which divide to produce neurons in the process of neurogenesis. The primary neural stem cells of the brain and spinal cord, termed radial glial cells, instead reside in the ventricular zone.
  In the developing cerebral cortex, which resides in the dorsal telencephalon, the SVZ and VZ are transient tissues that do not exist in the adult. However, the SVZ of the ventral telencephalon persists throughout life. The adult SVZ is composed of four distinct layers of variable thickness and cell density as well as cellular composition. Along with the dentate gyrus of the hippocampus, the SVZ is one of two places where neurogenesis has been found to occur in the adult mammalian brain. Adult SVZ neurogenesis takes the form of neuroblast precursors of interneurons that migrate to the olfactory bulb through the rostral migratory stream.
context_section_description: The subventricular zone (SVZ) is a region situated on the outside wall of each lateral ventricle of the vertebrate brain. It is present in both the embryonic and adult brain. In embryonic life, the SVZ refers to a secondary proliferative zone containing neural progenitor cells, which divide to produce neurons in the process of neurogenesis. The primary neural stem cells of the brain and spinal cord, termed radial glial cells, instead reside in the ventricular zone (VZ) (so-called because the VZ lines the inside of the developing ventricles).
  In the developing cerebral cortex, which resides in the dorsal telencephalon, the SVZ and VZ are transient tissues that do not exist in the adult. However, the SVZ of the ventral telencephalon persists throughout life. The adult SVZ is composed of four distinct layers of variable thickness and cell density as well as cellular composition. Along with the dentate gyrus of the hippocampus, the SVZ is one of two places where neurogenesis has been found to occur in the adult mammalian brain. Adult SVZ neurogenesis takes the form of neuroblast precursors of interneurons that migrate to the olfactory bulb through the rostral migratory stream. The SVZ also appears to be involved in the generation of astrocytes following a brain injury.
caption: Human subventricular zone. From a paper by Oscar Arias-Carrión, 2008
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