page_title: Branched-chain alpha-keto acid dehydrogenase complex
section_title: Biological function
hierarchical_section_title: Branched-chain alpha-keto acid dehydrogenase complex / Biological function
caption_attribution_description: English: This is the overall reaction catalyzed by the branched-chain alpha-ketoacid dehydrogenase complex.
context_page_description: The branched-chain α-ketoacid dehydrogenase complex is a multi-subunit complex of enzymes that is found on the mitochondrial inner membrane. This enzyme complex catalyzes the oxidative decarboxylation of branched, short-chain alpha-ketoacids. BCKDC is a member of the mitochondrial α-ketoacid dehydrogenase complex family comprising pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, key enzymes that function in the Krebs cycle.
context_section_description: In animal tissue, BCKDC catalyzes an irreversible step in the catabolism of the branched-chain amino acids L-isoleucine, L-valine, and L-leucine, acting on their deaminated derivatives (L-alpha-keto-beta-methylvalerate, alpha-ketoisovalerate, and alpha-ketoisocaproate, respectively). In bacteria, this enzyme participates in the synthesis of branched, long-chain fatty acids. In plants, this enzyme is involved in the synthesis of branched, long-chain hydrocarbons.
  The overall catabolic reaction catalyzed by the BCKDC is shown in Figure 1.
caption: Figure 1: This is the overall reaction catalyzed by the branched-chain alpha-ketoacid dehydrogenase complex.
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