page_title: Calciseptine
hierarchical_section_title: Calciseptine
caption_attribution_description: English: A model of the 3D structure of calciseptine, based on an NMR structure of its homologue FS2 (PDB: 1TFS&#8203;). Disulfide bridges are shown in yellow. The three residues that differ between FS2 and calciseptine are shown in red.
context_page_description: Calciseptine is a natural neurotoxin isolated from the black mamba Dendroaspis p. polylepis venom. This toxin consists of 60 amino acids with four disulfide bonds. Calciseptine specifically blocks L-type calcium channels, but not other voltage-dependent Ca²⁺ channels such as N-type and T-type channels.
context_section_description: Calciseptine (CaS) is a natural neurotoxin isolated from the black mamba Dendroaspis p. polylepis venom. This toxin consists of 60 amino acids with four disulfide bonds. Calciseptine specifically blocks L-type calcium channels, but not other voltage-dependent Ca²⁺ channels such as N-type and T-type channels.
caption: A model of the 3D structure of calciseptine, based on an NMR structure of its homologue FS2 (PDB: 1TFS​). Disulfide bridges are shown in yellow. The three residues that differ between FS2 and calciseptine are shown in red.
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