page_title: Mambalgins
hierarchical_section_title: Mambalgins
caption_attribution_description: English: The crystal structure of mambalgin-1, a 57-residue protein of the three-finger toxin (3FTx) family isolated from the venom of the black mamba. Mambalgins are potent inhibitors of acid-sensing ion channels. Unlike most 3FTx proteins, which are usually neurotoxins, mambalgins produce analgesia through ASIC inhibition without apparent toxic effect in laboratory tests. Mourier, Gilles; Salinas, Miguel; Kessler, Pascal; Stura, Enrico A.; Leblanc, Mathieu; Tepshi, Livia; Besson, Thomas; Diochot, Sylvie; Baron, Anne (2016-02-05). "Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition". Journal of Biological Chemistry. 291 (6): 2616–2629. doi:10.1074/jbc.m115.702373. PMC 4742732. PMID 26680001.
context_page_description: Mambalgins are peptides found in the venom of the black mamba, an elapid snake. Mambalgins are members of the three-finger toxin protein family and have the characteristic three-finger protein fold. First reported by French researchers in 2012, mambalgins are unusual members of the 3FTx family in that they have the in vivo effect of causing analgesia without apparent toxicity. Their mechanism of action is potent inhibition of acid-sensing ion channels.
context_section_description: Mambalgins are peptides found in the venom of the black mamba (Dendroaspis polylepis polylepis), an elapid snake. Mambalgins are members of the three-finger toxin (3FTx) protein family and have the characteristic three-finger protein fold. First reported by French researchers in 2012, mambalgins are unusual members of the 3FTx family in that they have the in vivo effect of causing analgesia without apparent toxicity. Their mechanism of action is potent inhibition of acid-sensing ion channels.
caption: The structure of mambalgin-1, showing the three "finger" loops in red (loop I), blue (loop II), and green (loop III), with core disulfide bonds highlighted in yellow.[1]
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