page_title: R2 RNA element
hierarchical_section_title: R2 RNA element
caption_attribution_description: English: Image has been uploaded to the Commons as part of the Molecular and Cellular Biology WikiProject in collaboration with the public-domain database Rfam. Here is the link to the discussion.
context_page_description: The R2 RNA element is a non-long terminal repeat retrotransposable element that inserts at a specific site in the 28S ribosomal RNA genes of most insect genomes. In order to insert itself into the genome, retrotransposon encoded protein protein makes a specific nick in one of the DNA strands at the insertion site and uses the 3′ hydroxyl group exposed by this nick to prime the reverse transcription process termed target primed reverse transcription, where the RNA genome is transcribed into DNA.
context_section_description: The R2 RNA element is a non-long terminal repeat (non-LTR) retrotransposable element that inserts at a specific site in the 28S ribosomal RNA (rRNA) genes of most insect genomes. In order to insert itself into the genome, retrotransposon encoded protein (R2) protein makes a specific nick in one of the DNA strands at the insertion site and uses the 3′ hydroxyl group exposed by this nick to prime the reverse transcription process termed target primed reverse transcription (TPRT), where the RNA genome is transcribed into DNA.
caption: Predicted secondary structure and sequence conservation of R2_retro_el
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