page_title: 3-hydroxy-3-methylglutaryl-CoA lyase
hierarchical_section_title: 3-hydroxy-3-methylglutaryl-CoA lyase
caption_attribution_description: English: HMG-CoA lyase dimer + hydroxyglutaric acid (green-red) + 2 Mg (l.blue), Human
context_page_description: 3-hydroxy-3-methylglutaryl-CoA lyase is an enzyme that in human is encoded by the HMGCL gene located on chromosome 1. It is a key enzyme in ketogenesis. It is a ketogenic enzyme in the liver that catalyzes the formation of acetoacetate from HMG-CoA within the mitochondria. It also plays a prominent role in the catabolism of the amino acid leucine.
context_section_description: 3-hydroxy-3-methylglutaryl-CoA lyase (or HMG-CoA lyase) is an enzyme that in human is encoded by the HMGCL gene located on chromosome 1. It is a key enzyme in ketogenesis (ketone body formation). It is a ketogenic enzyme in the liver that catalyzes the formation of acetoacetate from HMG-CoA within the mitochondria. It also plays a prominent role in the catabolism of the amino acid leucine.
caption: HMG-CoA lyase dimer, Human
exif: {}