page_title: Affilin
section_title: Structure
hierarchical_section_title: Affilin / Structure
caption_attribution_description: English: Cartoon representation of the molecular structure of protein registered with 2jdf code. Deutsch: Grafik des Molekularstruktur von jenem Protein, das mit 2jdf code registriert ist. Plattdüütsch: Grafik, de de Molekularstruktur von dat Protein wiest, dat mit’n Kood 2jdf registreert is.
context_page_description: Affilins are artificial proteins designed to selectively bind antigens. Affilin proteins are structurally derived from human ubiquitin. Affilin proteins are constructed by modification of surface-exposed amino acids of these proteins and isolated by display techniques such as phage display and screening. They resemble antibodies in their affinity and specificity to antigens but not in structure, which makes them a type of antibody mimetic. Affilin was developed by Scil Proteins GmbH as potential new biopharmaceutical drugs, diagnostics and affinity ligands.
context_section_description: Two proteins, gamma-B crystallin and ubiquitin, have been described as scaffolds for Affilin proteins. Certain amino acids in these proteins can be substituted by others without losing structural integrity, a process creating regions capable of binding different antigens, depending on which amino acids are exchanged. In both types, the binding region is typically located in a beta sheet structure, whereas the binding regions of antibodies, called complementarity-determining regions, are flexible loops.
caption: Human gamma-B crystallin, wild-type (PDB: 2JDF​). The beta strands making up the beta sheets are coloured blue.
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