page_title: Nezelof syndrome
section_title: Treatment
hierarchical_section_title: Nezelof syndrome / Treatment
caption_attribution_description: A bag with bone marrow ready to be used for transplant
context_page_description: Nezelof syndrome is an autosomal recessive congenital immunodeficiency condition due to underdevelopment of the thymus. The defect is a type of purine nucleoside phosphorylase deficiency with inactive phosphorylase, this results in an accumulation of deoxy-GTP which inhibits ribonucleotide reductase. Ribonucleotide reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides, thus, DNA replication is inhibited.
context_section_description: In terms of treatment for individuals with Nezelof syndrome, which was first  characterized in 1964, includes the following(how effective bone marrow transplant is uncertain) :
  Antimicrobial therapy
  IV immunoglobulin
  Bone marrow transplantation
  Thymus transplantation
  Thymus factors
caption: Bone marrow for transplant
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