page_title: Thiourea organocatalysis
section_title: Catalyst-substrate interactions
hierarchical_section_title: Thiourea organocatalysis / Catalyst-substrate interactions
caption_attribution_description: Deutsch: H.Brücken Koordination von Thiourea T1, Mike Kotke, selbst erstellt
context_page_description: Within the area of organocatalysis, urea organocatalysis describes the use of ureas and thioureas to accelerate and stereochemically alter organic transformations. The effects arise through hydrogen-bonding interactions between the substrate and the urea. Unlike classical catalysts, these organocatalysts interact by non-covalent interactions, especially hydrogen bonding. The scope of these small-molecule H-bond donors termed urea organocatalysis covers both non-stereoselective and stereoselective applications.
context_section_description: Hydrogen-bonding between thiourea derivatives and carbonyl substrates involve two hydrogen bonds provided by coplanar amino substituents in the (thio)urea.
    Squaramides engage in double H-bonding interactions and are often superior to thioureas.
caption: Ketone complex with Schreiner's N,N'-bis[3,5-bis(trifluoromethyl)phenyl thiourea.  The double hydrogen-bonding, clamp-like binding motif is evident.[4][7]
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