page_title: Ganglionic eminence
hierarchical_section_title: Ganglionic eminence
caption_attribution_description: English: Interneurons (green) migrating into the cerebral wall from the ganglionic eminence(GE) interact with radial glia (red) and can exhibit changes in direction of migration after contacting radial glia. Interneurons can use radial glia as a scaffold upon which to migrate as they ascend to the cortical plate (CP) or descend in the direction of the ventricular zone (VZ). Particular orientation and morphological dynamics of migration may be associated with particular subsets of interneurons. Once the interneurons invade the cortex from the ganglionic eminence, differential interactions between interneurons and radial glial scaffold and localized multidirectional migration of interneurons influenced by local guidance cues may facilitate interneuronal positioning within distinct domains of the developing cerebral cortex. Potential differences among interneurons and radial glia are indicated by shades of green and red, respectively. Putative local guidance cues are indicated by a gradient of pink. Blue arrows indicate direction of migration.
context_page_description: The ganglionic eminence is a transitory structure in the development of the nervous system that guides cell and axon migration. It is present in the embryonic and fetal stages of neural development found between the thalamus and caudate nucleus.
  The eminence is divided into three regions of the ventral ventricular zone of the telencephalon, where they facilitate tangential cell migration during embryonic development. Tangential migration does not involve interactions with radial glial cells; instead the interneurons migrate perpendicularly through the radial glial cells to reach their final location. The characteristics and function of the cells that follow the tangential migration pathway seem to be closely related to the location and precise timing of their production, and the GEs contribute significantly to building up the GABAergic cortical cell population. Another structure that the GEs contribute to is the basal ganglia. The GEs also guide the axons growing from the thalamus into the cortex and vice versa.
  In humans, the GEs disappear by one year of age.
context_section_description: The ganglionic eminence (GE) is a transitory structure in the development of the nervous system that guides cell and axon migration. It is present in the embryonic and fetal stages of neural development found between the thalamus and caudate nucleus.
  The eminence is divided into three regions of the ventral ventricular zone of the telencephalon (a lateral, medial and caudal eminence), where they facilitate tangential cell migration during embryonic development. Tangential migration does not involve interactions with radial glial cells; instead the interneurons migrate perpendicularly through the radial glial cells to reach their final location. The characteristics and function of the cells that follow the tangential migration pathway seem to be closely related to the location and precise timing of their production, and the GEs contribute significantly to building up the GABAergic cortical cell population. Another structure that the GEs contribute to is the basal ganglia. The GEs also guide the axons growing from the thalamus into the cortex and vice versa.
  In humans, the GEs disappear by one year of age. During development, neuronal migration continues until the extinction of the germ layer, at which point the remnants from the germ layer make up the eminences.
caption: Interneurons (green) migrate tangentially from the ganglionic eminence to the cerebral cortex. The tangentially migrating interneurons travel perpendicular to the radial glial cells (red). The radially migrating interneurons travel parallel to the radial glial cells.
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