page_title: Purine riboswitch
section_title: Adenine Riboswitch
hierarchical_section_title: Purine riboswitch / Adenine Riboswitch
caption_attribution_description: English: Tertiary structure of the purine riboswitch. The image was generated by Jmol from the PDB:1y26 structure.
context_page_description: A purine riboswitch is a sequence of ribonucleotides in certain messenger RNA that selectively binds to purine ligands via a natural aptamer domain. This binding causes a conformational change in the mRNA that can affect translation by revealing an expression platform for a downstream gene, or by forming a translation-terminating stem-loop. The ultimate effects of such translational regulation often take action to manage an abundance of the instigating purine, and might produce proteins that facilitate purine metabolism or purine membrane uptake.
context_section_description: The Adenine Riboswitch selectively recognizes adenine, and contains a uracil ribonucleotide in position 74 of the adenine-binding aptamer domain.  Some of the more frequently researched instances of this riboswitch are detailed below.
caption: A 3D representation of the adenine riboswitch.[7]
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