page_title: RICTOR
section_title: Function
hierarchical_section_title: RICTOR / Function
caption_attribution_description: English: Rictor is a subunit of the mTORC2 complex, which activates Akt/PKB signaling, leading to cell proliferation and survival.
context_page_description: Rapamycin-insensitive companion of mammalian target of rapamycin is a protein that in humans is encoded by the RICTOR gene.
  RICTOR and mTOR are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth.
context_section_description: RICTOR is a subunit of the mammalian target of rapamycin complex 2 (mTORC2) which contains mTOR, GβL, RICTOR (this protein) and mSIN1.
  The mammalian target of rapamycin (mTOR) is a highly conserved Ser/Thr kinase that regulates cell growth and proliferation.
  mTOR may exist as mTOR complex 1 (mTORC1) or mTOR complex 2 (mTORC2). RICTOR is a key component of mTORC2, which, unlike mTORC1, is not directly inhibited by rapamycin. mTORC2, and RICTOR, specifically, has been shown to phosphorylate Akt/protein kinase B (PKB) on SER473. This phosphorylation activates Akt/PKB, where deregulation of Akt/PKB has been implicated in cancer and diabetes.
  RICTOR and mTORC2 have been shown to play an essential role in embryonic growth and development, perhaps due to the control that mTORC2 exerts on actin cytoskeleton organization.
caption: RICTOR is a subunit of the mTORC2 complex, which activates Akt/PKB signaling, leading to cell proliferation and survival.
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