page_title: 11β-Hydroxysteroid dehydrogenase
hierarchical_section_title: 11β-Hydroxysteroid dehydrogenase
caption_attribution_description: English: 11-beta-hydroxysteroid dehydrogenase dimer + 2 NADP (green) + 2 inhibitor (white) + 2 Ni (blue), Human
context_page_description: 11β-Hydroxysteroid dehydrogenase is a family of enzymes that catalyze the conversion of inert 11 keto-products to active cortisol, or vice versa, thus regulating the access of glucocorticoids to the steroid receptors:
  11β-hydroxysteroid + NADP⁺ ⇌ an 11-oxosteroid + NADPH + H⁺
  Thus, the two substrates of this enzyme are 11beta-hydroxysteroid and NADP⁺, whereas its 3 products are 11-oxosteroid, NADPH, and H⁺.
  This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 11beta-hydroxysteroid:NADP⁺ 11-oxidoreductase. Other names in common use include corticosteroid 11β-dehydrogenase, β-hydroxysteroid dehydrogenase, 11β-hydroxy steroid dehydrogenase, corticosteroid 11-reductase, and dehydrogenase, 11β-hydroxy steroid. This enzyme participates in c21-steroid hormone metabolism and androgen and estrogen metabolism.
context_section_description: 11β-Hydroxysteroid dehydrogenase (HSD-11β or 11β-HSD) is a family of enzymes that catalyze the conversion of inert 11 keto-products (cortisone) to active cortisol, or vice versa, thus regulating the access of glucocorticoids to the steroid receptors:
  11β-hydroxysteroid + NADP⁺ ⇌ an 11-oxosteroid + NADPH + H⁺
  Thus, the two substrates of this enzyme are 11beta-hydroxysteroid and NADP⁺, whereas its 3 products are 11-oxosteroid, NADPH, and H⁺.
  This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 11beta-hydroxysteroid:NADP⁺ 11-oxidoreductase. Other names in common use include corticosteroid 11β-dehydrogenase, β-hydroxysteroid dehydrogenase, 11β-hydroxy steroid dehydrogenase, corticosteroid 11-reductase, and dehydrogenase, 11β-hydroxy steroid. This enzyme participates in c21-steroid hormone metabolism and androgen and estrogen metabolism.
caption: 11-beta-hydroxysteroid dehydrogenase 1, dimer, Human
exif: {}