page_title: EF-Tu
section_title: Biological functions
hierarchical_section_title: EF-Tu / Biological functions
caption_attribution_description: English: EF-Tu has a cyclical role in translation.
context_page_description: EF-Tu is a prokaryotic elongation factor responsible for catalyzing the binding of an aminoacyl-tRNA to the ribosome. It is a G-protein, and facilitates the selection and binding of an aa-tRNA to the A-site of the ribosome. As a reflection of its crucial role in translation, EF-Tu is one of the most abundant and highly conserved proteins in prokaryotes. It is found in eukaryotic mitochrondria as TUFM.
  As a family of elongation factors, EF-Tu also includes its eukaryotic and archaeal homolog, the alpha subunit of eEF-1.
caption: The cyclical role of EF-Tu in translation.  Structures are from PDBs 1EFT, 1TUI, and 1TTT.
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