page_title: Hans Horst Meyer
section_title: Scientific achievements
hierarchical_section_title: Hans Horst Meyer / Scientific achievements
caption_attribution_description: Deutsch: Reliefplatte mit Hans Horst Meyer im Profil
context_page_description: Hans Horst Meyer was a German pharmacologist. He studied medicine and did research in pharmacology. The Meyer-Overton hypothesis on the mode of action on general anaesthetics is partially named after him. He also discovered the importance of glucuronic acid as a reaction partner for drugs, and the mode of action of tetanus toxin on the body.
context_section_description: Meyer is best remembered for three discoveries. With Schmiedeberg, he discovered glucuronic acid as the most important reaction partner of drugs (in his case, a metabolite of camphor). He also discovered a relationship between the lipophilicity of general anaesthetics and their potency. Meyer concluded that lipophilicity was the essential factor in the effectiveness of an anaesthetic. These findings were summarized in three papers in Archiv für experimentelle Pathologie und Pharmakologie by Meyer and his coworker Fritz Baum, published in 1899. A year later, Charles Ernest Overton (1865–1933) independently came to the same conclusion. This correlation became known as the Meyer-Overton hypothesis. It has been called the most influential correlation in anaesthesia Meyer also discovered that tetanus toxin acts on the central nervous system and is transported there from the periphery via the motor neurons. This explains why the incubation time always takes several hours, and why therapy with antibodies is of limited value.
  Meyer and Rudolf Gottlieb wrote a major German pharmacology textbook that was published in nine editions between 1910 and 1936. he also played an important role in the development and implementation of drug regulation in Austria.
caption: Hans Horst Meyer Medal awarded by the Vienna Academy of Sciences
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