page_title: Antalarmin
section_title: Chemical Structure
hierarchical_section_title: Antalarmin / Chemical Structure
caption_attribution_description: English: Chemical structure of CRH1 receptor Non-peptide Antagonist CP-154,526 and its close analog, Antalarmin (CP-156,181)
context_page_description: Antalarmin is a drug that acts as a CRH1 antagonist.
  Corticotropin-releasing hormone, also known as Corticotropin-releasing factor, is an endogenous peptide hormone released in response to various triggers such as chronic stress and drug addiction. Such triggers result in the release of corticotropin, another hormone involved in the physiological response to stress. Chronic release of CRH and ACTH is believed to be directly or indirectly involved in many of the harmful physiological effects of chronic stress, such as excessive glucocorticoid release, stomach ulcers, anxiety, diabetes mellitus, osteoporosis, depression, and development of high blood pressure and consequent cardiovascular problems.
  Antalarmin is a non-peptide drug that blocks the CRH1 receptor, and, as a consequence, reduces the release of ACTH in response to chronic stress.
context_section_description: The synthesis of CP-154,526, a non-peptide antagonist of the CRH1 receptor, was first described in 1997. Antalarmin, or CP-156,181, is a close analog that is highly structurally similar and has been shown to be easier to synthesize. The findings from several chemical, pharmacokinetic and pharmacological studies indicate that the two compounds possess very similar in their properties.
caption: Chemical structure of CRH1 receptor Non-peptide Antagonist CP-154,526 and its close analog, Antalarmin (CP-156,181)
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