page_title: Integrase
section_title: In HIV
hierarchical_section_title: Integrase / In HIV
caption_attribution_description: English: Cartoon Structure of HIV enzyme; See Template:UniProt[752–1143]
context_page_description: Retroviral integrase is an enzyme produced by a retrovirus that integrates—forms covalent links between—its DNA into that of the host cell it infects. Retroviral INs are not to be confused with phage integrases, such as λ phage integrase, as discussed in site-specific recombination.
  The macromolecular complex of an IN macromolecule bound to the ends of the viral DNA ends has been referred to as the intasome; IN is a key component in this and the retroviral pre-integration complex.
context_section_description: HIV integrase is a 32 kDa protein produced from the C-terminal portion of the Pol gene product, and is an attractive target for new anti-HIV drugs.
  In November 2005, data from a phase 2 study of an investigational HIV integrase inhibitor, MK-0518, demonstrated that the compound has potent antiviral activity. On October 12, 2007, the Food and Drug Administration (U.S.) approved the integrase inhibitor Raltegravir (MK-0518, brand name Isentress).  The second integrase inhibitor, elvitegravir, was approved in the U.S. in August 2012.
caption: HIV Integrase shown in its full structure with its catalytic amino acids shown in ball and stick form.
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