page_title: S-adenosyl-L-homocysteine hydrolase
hierarchical_section_title: S-adenosyl-L-homocysteine hydrolase
caption_attribution_description: English: Cartoon representation of the molecular structure of protein registered with 1b3r code. Deutsch: Grafik des Molekularstruktur von jenem Protein, das mit 1b3r code registriert ist. Plattdüütsch: Grafik, de de Molekularstruktur von dat Protein wiest, dat mit’n Kood 1b3r registreert is.
context_page_description: S-adenosyl-L-homocysteine hydrolase is an enzyme of the activated methyl cycle, responsible for the reversible hydration of S-adenosyl-L-homocysteine into adenosine and homocysteine.
  AdoHcyase is a ubiquitous enzyme which binds and requires NAD⁺ as a cofactor. AdoHcyase is a highly conserved protein of about 430 to 470 amino acids. The family contains a glycine-rich region in the central part of AdoHcyase; a region thought to be involved in NAD-binding.
  AdoHcyase is significantly associated with adenosine deaminase deficiency, which classically manifests in severe combine immunodeficiency. Accumulated adenosine derivatives, dATPs, irreversibly bind to and inhibit AdoHcyase, promoting the buildup of S-adenosyl-L-homocystine, a potent inhibitor of methyl transfer reactions.
  This protein may use the morpheein model of allosteric regulation.
context_section_description: S-adenosyl-L-homocysteine hydrolase (EC 3.3.1.1) (AdoHcyase) is an enzyme of the activated methyl cycle, responsible for the reversible hydration of S-adenosyl-L-homocysteine into adenosine and homocysteine.
  AdoHcyase is a ubiquitous enzyme which binds and requires NAD⁺ as a cofactor. AdoHcyase is a highly conserved protein of about 430 to 470 amino acids. The family contains a glycine-rich region in the central part of AdoHcyase; a region thought to be involved in NAD-binding.
  AdoHcyase is significantly associated with adenosine deaminase deficiency, which classically manifests in severe combine immunodeficiency (SCID). Accumulated adenosine derivatives, dATPs, irreversibly bind to and inhibit AdoHcyase, promoting the buildup of S-adenosyl-L-homocystine (due to equilibrium constant favors S-adenosyl-L-homocystine), a potent inhibitor of methyl transfer reactions.
  This protein may use the morpheein model of allosteric regulation.
caption: Structure of S-adenosylhomocysteine hydrolase from rat liver.[1]
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