page_title: Ouabain
section_title: Sources
hierarchical_section_title: Ouabain / Sources
caption_attribution_description: Deutsch: Acokanthera schimperi. A blühender Zweig. B Fruchtzweig. 1 Kelch; 2 Korolle, aufgeschnitten; 3 Staubblatt; 4 Pistill; 5 Ovar; 6 Frucht, zum Teil aufgeschnitten; 7 Samen; 8 Querschnitt; 9 Längsschnitt in der Richtung a bis c; 10 Längsschnitt in der Richtung b bis d. A, B verkleinert, 1 bis 10 vergrössert. Latina: Acokanthera schimperi. Русский: Акокантера абиссинская. A — цветущая ветвь; B — ветвь с плодами; 1 — чашечка; 2 — разрезанный венчик; 3 — пыльник тычинки; 4 — пестик; 5 — завязь; 6 — частично разрезанный плод; 7 — семя; 8 — семя в поперечном разрезе; 9 — продольный разрез семени по линии a—c; 10 — продольный разрез семени по линии b—d.
context_page_description: Ouabain or also known as g-strophanthin, is a plant derived toxic substance that was traditionally used as an arrow poison in eastern Africa for both hunting and warfare. Ouabain is a cardiac glycoside and in lower doses, can be used medically to treat hypotension and some arrhythmias. It acts by inhibiting the Na/K-ATPase, also known as the sodium-potassium ion pump. However, adaptations to the alpha-subunit of the Na+/K+-ATPase via amino acid substitutions, have been observed in certain species, namely some herbivore- insect species, that have resulted in toxin resistance.
  It is classified as an extremely hazardous substance in the United States as defined in Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act, and is subject to strict reporting requirements by facilities which produce, store, or use it in significant quantities.
context_section_description: Ouabain can be found in the roots, stems, leaves, and seeds of the Acokanthera schimperi and Strophanthus gratus plants, both of which are native to eastern Africa.
caption: Acokanthera schimperi plant.
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