page_title: Acetylation
section_title: Acetylation of STAT3
hierarchical_section_title: Acetylation / Protein acetylation / Lysine acetylation and deacetylation / STAT3 / Acetylation of STAT3
caption_attribution_description: English: Structure and acetylation residue of STAT3
context_page_description: Acetylation describes a reaction that introduces an acetyl functional group into a chemical compound. Deacetylation is the removal of an acetyl group.
  Acetylation refers to the process of introducing an acetyl group into a compound, namely the substitution of an acetyl group for an active hydrogen atom. A reaction involving the replacement of the hydrogen atom of a hydroxyl group with an acetyl group yields a specific ester, the acetate. Acetic anhydride is commonly used as an acetylating agent reacting with free hydroxyl groups. For example, it is used in the synthesis of aspirin, heroin, and THC-O-acetate.
context_section_description: The acetylation of Lys685 of STAT3 is important for STAT3 homo-dimerization, which is essential for the DNA-binding and the transcriptional activation of oncogenes. The acetylation of STAT3 is catalyzed by histone acetyltransferase p300, and reversed by type 1 histone deacetylase. The lysine acetylation of STAT3 is also elevated in cancer cells.
caption: Structure and acetylation residue of STAT3
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