page_title: Phosphoribosylaminoimidazolesuccinocarboxamide synthase
hierarchical_section_title: Phosphoribosylaminoimidazolesuccinocarboxamide synthase
caption_attribution_description: English: Cartoon representation of the molecular structure of protein registered with 1kut code. Deutsch: Grafik des Molekularstruktur von jenem Protein, das mit 1kut code registriert ist. Plattdüütsch: Grafik, de de Molekularstruktur von dat Protein wiest, dat mit’n Kood 1kut registreert is.
context_page_description: In molecular biology, the protein domain SAICAR synthase is an enzyme which catalyses a reaction to create SAICAR. In enzymology, this enzyme is also known as phosphoribosylaminoimidazolesuccinocarboxamide synthase. It is an enzyme that catalyzes the chemical reaction
  ATP + 5-amino-1-imidazole-4-carboxylate + L-aspartate ADP + phosphate +-2-[5-amino-1-imidazole-4-carboxamido]succinate
  The 3 substrates of this enzyme are ATP, 5-amino-1-imidazole-4-carboxylate, and L-aspartate, whereas its 3 products are ADP, phosphate, and-2-[5-amino-1-imidazole-4-carboxamido]succinate.
  This enzyme belongs to the family of ligases, to be specific those forming carbon-nitrogen bonds as acid-D-amino-acid ligases. The systematic name of this enzyme class is 5-amino-1-imidazole-4-carboxylate:L-aspartate ligase. This enzyme participates in purine metabolism.
  This particular protein family is of huge importance as it is found in all three domains of life. It is the seventh step in the pathway of purine biosynthesis. Purines are vital to all cells as they are involved in energy metabolism and DNA synthesis.
context_section_description: In molecular biology, the protein domain SAICAR synthase is an enzyme which catalyses a reaction to create SAICAR. In enzymology,  this enzyme is also known as phosphoribosylaminoimidazolesuccinocarboxamide synthase (EC 6.3.2.6). It is an enzyme that catalyzes the chemical reaction
  ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate  ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
  The 3 substrates of this enzyme are ATP, 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, and L-aspartate, whereas its 3 products are ADP, phosphate, and (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate.
  This enzyme belongs to the family of ligases, to be specific those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases).  The systematic name of this enzyme class is 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming).   This enzyme participates in purine metabolism.
  This particular protein family is of huge importance as it is found in all three domains of life. It is the seventh step in the pathway of purine biosynthesis. Purines are vital to all cells as they are involved in energy metabolism and DNA synthesis. Furthermore, they are of specific interest to scientific researchers as the study of the purine biosynthesis pathway could lead to the development of chemotherapeutic drugs. This is because most cancers lack a salvage pathway for adenine nucleotides and rely entirely on the SAICAR pathway.
caption: Structural genomics, protein TM1243, (SAICAR synthetase)
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