page_title: Calmodulin binding domain
hierarchical_section_title: Calmodulin binding domain
caption_attribution_description: English: Cartoon representation of the molecular structure of protein registered with 1kkd code. Deutsch: Grafik des Molekularstruktur von jenem Protein, das mit 1kkd code registriert ist. Plattdüütsch: Grafik, de de Molekularstruktur von dat Protein wiest, dat mit’n Kood 1kkd registreert is.
context_page_description: In molecular biology, calmodulin binding domain is a protein domain found in small-conductance calcium-activated potassium channels. These channels are independent of voltage and gated solely by intracellular Ca²⁺. They are heteromeric complexes that comprise pore-forming alpha-subunits and the Ca²⁺-binding protein calmodulin. CaM binds to the SK channel through the CaMBD, which is located in an intracellular region of the alpha-subunit immediately carboxy-terminal to the pore. Channel opening is triggered when Ca²⁺ binds the EF hands in the N-lobe of CaM. The structure of this domain complexed with CaM is known. This domain forms an elongated dimer with a CaM molecule bound at each end; each CaM wraps around three alpha-helices, two from one CaMBD subunit and one from the other.
context_section_description: In molecular biology, calmodulin binding domain (CaMBD) is a protein domain found in small-conductance calcium-activated potassium channels (SK channels). These channels are independent of voltage and gated solely by intracellular Ca²⁺. They are heteromeric complexes that comprise pore-forming alpha-subunits and the Ca²⁺-binding protein calmodulin (CaM). CaM binds to the SK channel through the CaMBD, which is located in an intracellular region of the alpha-subunit immediately carboxy-terminal to the pore. Channel opening is triggered when Ca²⁺ binds the EF hands in the N-lobe of CaM. The structure of this domain complexed with CaM is known. This domain forms an elongated dimer with a CaM molecule bound at each end; each CaM wraps around three alpha-helices, two from one CaMBD subunit and one from the other.
caption: solution structure of the calmodulin binding domain (cambd) of small conductanceCa2+-activated potassium channels (sk2)
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