page_title: Monoallelic gene expression
hierarchical_section_title: Monoallelic gene expression
caption_attribution_description: English: Two chromosomes are depicted as Paternal and Maternal. Bi-allelically expressed genes are transcribed from both Paternal and Maternal chromosomes, whereas mono-allelic expression occurs only from one of them.
context_page_description: Monoallelic gene expression is the phenomenon of the gene expression, when only one of the two gene copies is actively expressed, while the other is silent. Diploid organisms bear two homologous copies of each chromosome, a gene can be expressed from both chromosomes or from only one. MAE can be Random monoallelic expression or Constitutive monoallelic expression. Constitutive monoallelic expression occurs from the same specific allele throughout the whole organism or tissue, as a result of genomic imprinting. RME is a broader class of monoallelic expression, which is defined by random allelic choice in somatic cells, so that different cells of the multi-cellular organism express different alleles.
context_section_description: Monoallelic gene expression (MAE) is the phenomenon of the gene expression, when only one of the two gene copies (alleles) is actively expressed (transcribed), while the other is silent. Diploid organisms bear two homologous copies of each chromosome (one from each parent), a gene can be expressed from both chromosomes (biallelic expression) or from only one (monoallelic expression). MAE can be Random monoallelic expression (RME) or Constitutive monoallelic expression (constitutive). Constitutive monoallelic expression occurs from the same specific allele throughout the whole organism or tissue, as a result of genomic imprinting. RME is a broader class of monoallelic expression, which is defined by random allelic choice in somatic cells, so that different cells of the multi-cellular organism express different alleles.
caption: Diagram shows the difference between mono- and bi-allelic expression
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