page_title: Malate dehydrogenase
section_title: Protein families
hierarchical_section_title: Malate dehydrogenase / Protein families
caption_attribution_description: English: 3-D protein structure of the mobile loop region in malate dehydrogenase in the closed and open conformation. The MDH closed conformation is shown in pink (indicated by the pink arrow) while the open conformation is shown in cyan (indicated by the cyan arrow).
context_page_description: Malate dehydrogenase is an enzyme that reversibly catalyzes the oxidation of malate to oxaloacetate using the reduction of NAD⁺ to NADH. This reaction is part of many metabolic pathways, including the citric acid cycle. Other malate dehydrogenases, which have other EC numbers and catalyze other reactions oxidizing malate, have qualified names like malate dehydrogenase.
context_section_description: The malate dehydrogenase family contains L-lactate dehydrogenase and L-2-hydroxyisocaproate dehydrogenases. L-lactate dehydrogenases catalyzes the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. The N-terminus is a Rossmann NAD-binding fold and the C-terminus is an unusual alpha+beta fold.
caption: 3-D crystal structure of the mobile loop region in malate dehydrogenase in the closed and open conformation. The MDH closed conformation is shown in pink (indicated by the pink arrow) while the open conformation is shown in cyan (indicated by the cyan arrow).
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