page_title: Diguanylate cyclase
hierarchical_section_title: Diguanylate cyclase
caption_attribution_description: English: Crystal structure of diguanylate cyclase PleD in complex with c-di-GMP from Caulobacter crecentus
context_page_description: In enzymology, diguanylate cyclase, also known as diguanylate kinase, is an enzyme that catalyzes the chemical reaction:
  2 Guanosine triphosphate ↔ 2 diphosphate + cyclic di-3',5'-guanylate
  The substrates of diguanylate cyclases are two molecules of guanosine triphosphate and the products are two molecules of diphosphate and one molecule of cyclic di-3’,5’-guanylate.
  Degradation of cyclic di-GMP to guanosine monophosphate is catalyzed by a phosphodiesterase.
context_section_description: In enzymology, diguanylate cyclase, also known as diguanylate kinase (EC 2.7.7.65), is an enzyme that catalyzes the chemical reaction:
  2 Guanosine triphosphate ↔ 2 diphosphate + cyclic di-3',5'-guanylate
  The substrates of diguanylate cyclases (DGCs) are two molecules of guanosine triphosphate (GTP) and the products are two molecules of diphosphate and one molecule of cyclic di-3’,5’-guanylate (cyclic di-GMP).
  Degradation of cyclic di-GMP to guanosine monophosphate (GMP) is catalyzed by a phosphodiesterase (PDE).
caption: Crystal structure of diguanylate cyclase PleD in complex with c-di-GMP from Caulobacter crescentus; rendering based on PDB: 2WB4​
exif: {"Image ExifOffset": "28", "EXIF ImageDescription": "ImageSource=RCSB PDB; StructureID=2wb4; DOI=http://dx.doi.org/10.2210/pdb2wb4/pdb;"}