page_title: Titanocene dichloride
section_title: Reactions affecting Cp ligands
hierarchical_section_title: Titanocene dichloride / Reactions / Reactions affecting Cp ligands
caption_attribution_description: English: improved drawing indicating probable weakness of Ti--Ti bond
context_page_description: Titanocene dichloride is the organotitanium compound with the formula (η⁵-C₅H₅)₂TiCl₂, commonly abbreviated as Cp₂TiCl₂. This metallocene is a common reagent in organometallic and organic synthesis. It exists as a bright red solid that slowly hydrolyzes in air. It shows antitumour activity and was the first non-platinum complex to undergo clinical trials as a chemotherapy drug.
context_section_description: One Cp ligand can be removed from Cp₂TiCl₂ to give tetrahedral CpTiCl₃. This conversion can be effected with TiCl₄ or by reaction with SOCl₂.
  Titanocene itself, TiCp₂, is so highly reactive that it rearranges into a Tiᴵᴵᴵ hydride dimer and has been the subject of much investigation. This dimer can be trapped by conducting the reduction of titanocene dichloride in the presence of ligands; in the presence of benzene, a fulvalene complex, μ(η⁵:η⁵-fulvalene)-di-(μ-hydrido)-bis(η⁵-cyclopentadienyltitanium), can be prepared and the resulting solvate structurally characterised by X-ray crystallography.  The same compound had been reported earlier by a lithium aluminium hydride reduction  and sodium amalgam reduction of titanocene dichloride, and studied by ¹H NMR prior to its definitive characterisation.
caption: "Titanocene" is not Ti(C5H5)2, but rather this isomer with a fulvalene dihydride structure.[13][14]
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