page_title: 4-Hydroxycoumarins
hierarchical_section_title: 4-Hydroxycoumarins
caption_attribution_description: rat poison on the Schelde river dike, Steendorp, Belgium VLAAMS GEWEST AFDELING WATER Tel.: 02/553 21 11 Bevat 0,005% BROMADIALONE EERSTE HULP: in geval van inname, water drinken, laten braken en een arts waarschuwen. Eventueel antigifcentrum bellen: 070/245 245 AANWIJZINGEN VOOR DE GENEESHEER. Het product is schadelijk bij inname van grote hoeveelheden en werkt cumulatief. Bevat een antibloedstollend middel met verlengde werking. Tegengif Vitamine K1 BRUINE RATBESTRIJDING FLEMISH REGION DEPARTMENT WATER Tel.: 02/553 21 11 Contains 0.005% BROMADIALONE FIRST AID: in case of ingestion, drink water, induce vomiting and notify a physician. Call poison control center when necessary: 070/245 245 DIRECTIONS FOR PHYSICIAN. The product is harmful when ingested in large quantities and has a cumulative effect. Contains an anticoagulant with prolonged activity. Antidote Vitamin K1 BROWN RAT DESTRUCTION
context_page_description: 4-Hydroxycoumarins belong to a class of vitamin K antagonist anticoagulant drug molecules derived from coumarin by adding a hydroxy group at the 4 position to obtain 4-hydroxycoumarin, then adding a large aromatic substituent at the 3-position. The large 3-position substituent is required for anticoagulant activity.
  The primary mechanism of the 4-hydroxycoumarin drugs is the inhibition of vitamin K epoxide reductase. These compounds are not direct antagonists of vitamin K, but rather act to deplete reduced vitamin K in tissues. For this reason vitamin K antagonizes their effect, and this has led to the loose terminology of vitamin K antagonism.
context_section_description: 4-Hydroxycoumarins belong to a class of vitamin K antagonist (VKA) anticoagulant drug molecules derived from coumarin by adding a hydroxy group at the 4 position to obtain 4-hydroxycoumarin, then adding a large aromatic substituent at the 3-position (the ring-carbon between the hydroxyl and the carbonyl). The large 3-position substituent is required for anticoagulant activity.
  The primary mechanism of the 4-hydroxycoumarin drugs is the inhibition of vitamin K epoxide reductase. These compounds are not direct antagonists (in the pharmaceutical sense) of vitamin K, but rather act to deplete reduced vitamin K in tissues. For this reason vitamin K antagonizes their effect, and this has led to the loose terminology of vitamin K antagonism.
caption: Warning label on a tube of "brown rat" poison laid on a dike of the Scheldt river in Steendorp, Belgium. The tube contains bromadiolone, a second-generation ("super-warfarin") anticoagulant. The label in Dutch states, in part: Contains an anticoagulant with prolonged activity. Antidote Vitamin K1.
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