page_title: Guanine nucleotide exchange factor
hierarchical_section_title: Guanine nucleotide exchange factor
caption_attribution_description: English: Guanosine diphosphate
context_page_description: Guanine nucleotide exchange factors are proteins or protein domains that activate monomeric GTPases by stimulating the release of guanosine diphosphate to allow binding of guanosine triphosphate. A variety of unrelated structural domains have been shown to exhibit guanine nucleotide exchange activity. Some GEFs can activate multiple GTPases while others are specific to a single GTPase.
context_section_description: Guanine nucleotide exchange factors (GEFs) are proteins or protein domains that activate monomeric GTPases by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP).  A variety of unrelated structural domains have been shown to exhibit guanine nucleotide exchange activity. Some GEFs can activate multiple GTPases while others are specific to a single GTPase.
caption: GDP
exif: {}