page_title: Coagulation
section_title: Physiology
hierarchical_section_title: Coagulation / Physiology
caption_attribution_description: English: vWF bound to the extracellular domain of GP1b alpha.
context_page_description: Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a blood clot. It potentially results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The mechanism of coagulation involves activation, adhesion and aggregation of platelets, as well as deposition and maturation of fibrin.
  Coagulation begins almost instantly after an injury to the blood vessel has damaged the endothelium lining the blood vessel. Exposure of blood to the subendothelial space initiates two processes: changes in platelets, and the exposure of subendothelial tissue factor to plasma factor VII, which ultimately leads to cross-linked fibrin formation. Platelets immediately form a plug at the site of injury; this is called primary hemostasis. Secondary.
  hemostasis occurs simultaneously: additional coagulation factors beyond factor VII respond in a cascade to form fibrin strands, which strengthen the platelet plug.
  Disorders of coagulation are disease states which can result in problems with hemorrhage, bruising, or thrombosis.
  Coagulation is highly conserved throughout biology.
caption: The interaction of vWF and GP1b alpha. The GP1b receptor on the surface of platelets allows the platelet to bind to vWF, which is exposed upon damage to vasculature. The vWF A1 domain (yellow) interacts with the extracellular domain of GP1ba (blue).
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