page_title: Mouse Models of Human Cancer database
section_title: Patient Derived Xenograft models (PDX)
hierarchical_section_title: Mouse Models of Human Cancer database / Patient Derived Xenograft models (PDX)
caption_attribution_description: English: This image shows an example search using the PDX Like Me search tool on the Mouse Models of Human Cancer database.
context_page_description: The laboratory mouse has been instrumental in investigating the genetics of human disease, including cancer, for over 110 years. The laboratory mouse has physiology and genetic characteristics very similar to humans providing powerful models for investigation of the genetic characteristics of disease.
  The Mouse Models of Human Cancer database is a unique, comprehensive online knowledgebase of mouse models of human cancer hosted by The Jackson Laboratory with funding from the National Cancer Institute. MMHCdb is part of the Mouse Genome Informatics consortium and was first released in 1998 as the Mouse Tumor Biology database. MMHCdb contains genetic and genomic information about inbred mouse strains, genetically engineered mouse models and Patient Derived Xenograft models of human cancer. Data in MMHCdb is expertly curated from peer-reviewed scientific publications or obtained as direct data submissions from individual investigators and large-scale research initiatives. MMHCdb, in collaboration with EMBL-EBI, co-developed the PDX Finder resource which serves as a global catalog of PDX models.
context_section_description: A Patient Derived Xenograft (PDX) is generated by the implantation of human tumor tissue in an immunodeficient or humanized host mouse strain. PDXs are a powerful pre-clinical model system for evaluating efficacy of cancer therapy. Most of the PDX models in MMHCdb are from xenografts in the immunodeficient NSG host strain (aka, NOD scid gamma;  NOD.Cg-Prkdc<scid> Il2rg<tm1>Wjl/SzJ) mice developed at The Jackson Laboratory.  MMHCdb allows researchers to search for PDX models by such parameters as cancer site, diagnosis, genomic properties of the engrafted human tumor, and model treatment response. Fig. 3 shows the output of a search for PDX models whose engrafted tumors have amplified KRAS, the TP53 A159V mutation, a deletion of the ALB gene, and high KIT expression. 
  MMHCdb and EMBL-EBI co-developed PDX Finder, an searchable catalog of PDX models available from repositories around the world.
caption: Fig. 3. PDX Like Me search example.
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