page_title: Estriol (medication)
section_title: Pharmacokinetics
hierarchical_section_title: Estriol (medication) / Pharmacology / Pharmacokinetics
caption_attribution_description: English: Serum levels of estriol after a single dose during continuous daily administration of 8 mg oral estriol (with or without a meal at 4 hours) or 0.5 mg vaginal estriol in women. Source of values: &#32;(2005).&#32;"Pharmacology of estrogens and progestogens: influence of different routes of administration". Climacteric&#32;8 Suppl 1: 3–63. DOI:10.1080/13697130500148875. PMID 16112947.
context_page_description: Estriol, sold under the brand name Ovestin among others, is an estrogen medication and naturally occurring steroid hormone which is used in menopausal hormone therapy. It is also used in veterinary medicine as Incurin to treat urinary incontinence due to estrogen deficiency in dogs. The medication is taken by mouth in the form of tablets, as a cream that is applied to the skin, as a cream or pessary that is applied in the vagina, and by injection into muscle.
  Estriol is well-tolerated and produces relatively few adverse effects. Side effects may include breast tenderness, vaginal discomfort and discharge, and endometrial hyperplasia. Estriol is a naturally occurring and bioidentical estrogen, or an agonist of the estrogen receptor, the biological target of estrogens like endogenous estradiol. It is an atypical and relatively weak estrogen, with much lower potency than estradiol. When present continuously however, estriol produces full estrogenic effects similarly to estradiol.
  Estriol was first discovered in 1930, and was introduced for medical use shortly thereafter. Estriol esters such as estriol succinate are also used.
caption: Estriol (E3) levels after a single dose during continuous daily administration of 8 mg oral estriol (with or without a meal at 4 hours) or 0.5 mg vaginal estriol.[4] Note the second peak with oral estriol caused by consumption of a meal at 4 hours, which is due to enterohepatic recycling of the compound and a consequent resurgence in levels.[4]
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