page_title: MIF4GD
section_title: Expression and regulation
hierarchical_section_title: MIF4GD / Expression and regulation
caption_attribution_description: English: Conceptual translation for the isoform 1 of the MIF4GD protein, annotating for the MIF4G domain, low complexity region, conserved amino acids, RNA-binding proteins, miRNA binding sites, predicted stem-loop structures in UTRs, and predicted post-translational modifications.
context_page_description: MIF4GD, or MIF4G domain-containing protein, is a protein which in humans is encoded by the MIF4GD gene. It is also known as SLIP1, SLBP-interacting protein 1, AD023, and MIFD. MIF4GD is expressed ubiquitously in humans, and has been found to be involved in activating proteins for histone mRNA translation, alternative splicing and translation of mRNAs, and is a factor in the regulation of cell proliferation.
context_section_description: MIF4GD is found only in animals, and is expressed ubiquitously in the body, though it has been discovered to be expressed at a somewhat higher rate in lymph nodes, bone marrow and testes. MIF4GD is expressed at an average rate that is 1.7 times higher than the average gene. 
  The promoter region of MIF4GD is approximately 1137 nucleotide base pairs long, and is predicted to interact with various transcription factors. The 5' untranslated region of MIF4GD mRNA transcripts is relatively short, at a length of around 137 nucleotides, and is predicted to form stem-loops and interior-loops to which RNA-binding proteins may bind. The 3' untranslated region is longer, at a length of approximately 510 nucleotides. The 3' UTR is also predicted to form stem-loops, interior-loops, and bulge-loops, as well as more complex secondary structures, and is predicted to bind to RNA-binding proteins and miRNAs at or near these sites.
caption: Conceptual Translation of MIF4GD mRNA and resulting protein. The MIF4G domain is highlighted in yellow, and a low complexity domain is highlighted in light purple. Predicted RNA-binding protein binding sites are highlighted in green, predicted miRNA binding sites are highlighted in pink, and predicted stem-loops are highlighted in blue. Conserved amino acids are bolded and/or underlined.
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