page_title: ESCRT
section_title: ESCRT complexes and accessory proteins
hierarchical_section_title: ESCRT / ESCRT complexes and accessory proteins
caption_attribution_description: English: Same as previous with Tsg101 fixed
context_page_description: The endosomal sorting complexes required for transport machinery is made up of cytosolic protein complexes, known as ESCRT-0, ESCRT-I, ESCRT-II, and ESCRT-III. Together with a number of accessory proteins, these ESCRT complexes enable a unique mode of membrane remodeling that results in membranes bending/budding away from the cytoplasm. These ESCRT components have been isolated and studied in a number of organisms including yeast and humans.
  The ESCRT machinery plays a vital role in a number of cellular processes including multivesicular body biogenesis, cellular abscission, and viral budding. Multivesicular body biogenesis is a process in which ubiquitin tagged proteins enter organelles called endosomes via the formation of vesicles. This process is essential for cells to destroy misfolded and damaged proteins. Without ESCRT machinery, these proteins can build up and lead to neurodegenerative disease. For example, abnormalities in ESCRT-III components can lead to neurological disorders such as hereditary spastic paraplegia. Cellular abscission, the process by which the membrane connecting two daughter cells is cleaved, is also mediated by ESCRT machinery.
context_section_description: Each of the ESCRT complexes and accessory proteins have unique structures that enable distinct biochemical functions. A number of synonyms exist for each protein component of the ESCRT machinery, both for yeast and metazoans. A summary table of all of these proteins is provided below.
  In yeast, the following complexes/accessory proteins exist as follows:
caption: Summary of ESCRT machinery and accessory proteins.[3][5]
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