page_title: NADH dehydrogenase (quinone)
hierarchical_section_title: NADH dehydrogenase (quinone)
caption_attribution_description: English: Structure of NADH dehydrogenase (quinone)
context_page_description: In enzymology, a NADH dehydrogenase (quinone) is an enzyme that catalyzes the chemical reaction
  NADH + H⁺ + a quinone NAD⁺ + a quinol
  The 3 substrates of this enzyme are NADH, H⁺, and a quinone, whereas its two products are NAD⁺ and a quinol.
  This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with other acceptors. The systematic name of this enzyme class is NADH: oxidoreductase. Other names in common use include reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase, NADH-quinone oxidoreductase, NADH ubiquinone oxidoreductase, DPNH-menadione reductase, D-diaphorase, and NADH2 dehydrogenase (quinone), and mitochondrial complex I. This enzyme participates in oxidative phosphorylation. Several compounds are known to inhibit this enzyme, including AMP, and 2,4-dinitrophenol. NADH dehydrogenase is involved in the first step of the electron transport chain of oxidative phosphorylation. Any change in the electron transport component caused by a mutation might effect the normal electron flow.
context_section_description: In enzymology, a NADH dehydrogenase (quinone) (EC 1.6.5.11) is an enzyme that catalyzes the chemical reaction
  NADH + H⁺ + a quinone  NAD⁺ + a quinol
  The 3 substrates of this enzyme are NADH, H⁺, and a quinone  (electron acceptor), whereas its two products are NAD⁺ and a quinol (reduced acceptor).
  This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with other acceptors.  The systematic name of this enzyme class is NADH:(quinone-acceptor) oxidoreductase. Other names in common use include reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase, NADH-quinone oxidoreductase, NADH ubiquinone oxidoreductase, DPNH-menadione reductase, D-diaphorase, and NADH2 dehydrogenase (quinone), and mitochondrial (mt) complex I.  This enzyme participates in oxidative phosphorylation.  Several compounds are known to inhibit this enzyme, including AMP, and 2,4-dinitrophenol. NADH dehydrogenase is involved in the first step of the electron transport chain of oxidative phosphorylation (OXPHOS). Any change in the electron transport component caused by a mutation might effect the normal electron flow. This might be leading "an increase of bifurcation and generation of superoxidase radicals and increase oxidative stress in various types of cancer cells."
  In the electron transport chain NADH is mainly used to create a concentration gradient of hydrogen in order to make ATP. Since After NADH is oxidized a hydrogen is pumped out and NAD⁺  will be a product.
caption: Structure of NADH dehydrogenase (quinone). PDB entry 3iam[1]
exif: {}