page_title: C12orf60
section_title: Protein interactions
hierarchical_section_title: C12orf60 / Protein interactions
caption_attribution_description: English: Protein Interactions of c12orf60 from STRING and GeneMANIA Search. All hits from STRING (left) were from text-mining, and all hits from GeneMANIA (right) were from co-expression.
context_page_description: Uncharacterized protein C12orf60 is a protein that in humans is encoded by the C12orf60 gene. The gene is also known as LOC144608 or MGC47869. The protein lacks transmembrane domains and helices, but it is rich in alpha-helices. It is predicted to localize in the nucleus.
  The C12orf60 mature mRNA transcript is 1139 nucleotides long and encodes a protein containing 245 amino acids. The protein lacks transmembrane domains and helices, but it is rich in alpha-helices. It is predicted to localize in the nucleus, but its function is not yet well understood by the scientific community. The gene was listed as a potential biomarker for detecting the efficacy of allergen immunotherapy.
  The gene is highly expressed in the testes and colon, but it is also expressed in the kidney, breast carcinomas, brain, and various endocrine glands.
context_section_description: Rolland et al. found that C12orf60 interacts with BMP4 (bone morphogenetic protein 4). BMP4 induces bone and cartilage formation. It also acts in mesoderm induction and fracture repair.
  Several other proteins might also interact with C12orf60, and some are predicted to be co-expressed with the protein. Possible protein interactions include L3MBTL4, C3orf67, FAM78A, and PXDC1. Rats that overexpressed L3MBTL4 had higher blood pressure and heart rate.
  Proteins that are thought to be co-expressed alongside C12orf60 include ELMOD2, TTC30B, and BCDIN3D. ELMOD2 is thought to be involved in antiviral responses and causing familial idiopathic pulmonary fibrosis. TTC30B is involved in the organelle biogenesis and maintenance pathway as well as intraflagellar transport. BCDIN3D is a methyltransferase and serves as a negative regulator of miRNA processing. As there is no agreement from various sources on any protein-protein interaction, it is difficult to determine if any of these interactions actually occur.
caption: C12orf60 protein interaction (left) and co-expression (right).
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