page_title: Lattice corneal dystrophy
section_title: Genetics
hierarchical_section_title: Lattice corneal dystrophy / Genetics
caption_attribution_description: English: Lattice corneal dystrophy type II. Black and white light micrograph showing deposits of amyloid in cornea. Congo red stain (Reproduced with permission from Klintworth [2]). Klintworth Orphanet Journal of Rare Diseases 2009 4:7 doi:10.1186/1750-1172-4-7Русский: Решётчатая дистрофия роговицы тип II.
context_page_description: Lattice corneal dystrophy type, is a rare form of corneal dystrophy. It has no systemic manifestations, unlike the other type of the dystrophy, Lattice corneal dystrophy type II. Lattice corneal dystrophy was first described by Swiss ophthalmologist Hugo Biber in 1890.
  Lattice dystrophy gets its name from an accumulation of amyloid deposits, or abnormal protein fibers, throughout the middle and anterior stroma.
context_section_description: Lattice corneal dystrophy has two types:
  type I: with no systemic association. It is caused by mutations in TGFBI gene encoding keratoepithelin, which maps to chromosome 5q.
  type II or Finnish type amyloidosis: associated with manifestations of systemic amyloidosis due to accumulation of gelsolin. Associated conditions may include cutis laxa and ataxia.
  type III is also described which has an onset at age 70 to 90 years and is not associated with systemic amyloidosis.
caption: Lattice corneal dystrophy type II. Black and white light micrograph showing deposits of amyloid in cornea. Congo red stain.
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