page_title: Oxcarbazepine
section_title: Pharmacogenetics
hierarchical_section_title: Oxcarbazepine / Pharmacology / Pharmacogenetics
caption_attribution_description: English: Trileptal Oxcarbazepine NOVARTIS Oral Suspension 100 mg/ml
context_page_description: Oxcarbazepine, sold under the brand name Trileptal among others, is a medication used to treat epilepsy and bipolar disorder. For epilepsy it is used for both focal seizures and generalized seizures. It has been used both alone and as add-on therapy in people with bipolar who have had no success with other treatments. It is taken by mouth.
  Common side effects include nausea, vomiting, dizziness, drowsiness, double vision and trouble with walking. Serious side effects may include anaphylaxis, liver problems, pancreatitis, suicide, and an abnormal heart beat. While use during pregnancy may harm the baby, use may be less risky than having a seizure. Use is not recommended during breastfeeding. In those with an allergy to carbamazepine there is a 25% risk of problems with oxcarbazepine. How it works is not entirely clear.
  Oxcarbazepine was patented in 1969 and came into medical use in 1990. It is available as a generic medication. A month supply in the United Kingdom costs the NHS about £6.50 as of 2019. In the United States the wholesale cost of this amount is about $7.15.
context_section_description: The human leukocyte antigen (HLA) allele B*1502 has been associated with an increased incidence of Stevens–Johnson syndrome and toxic epidermal necrolysis in people treated with carbamazepine, and thus those treated with oxcarbazepine might have similar risks. People of Asian descent are more likely to carry this genetic variant, especially some Malaysian populations, Koreans (2%), Han Chinese (2–12%), Indians (6%), Thai (8%), and Philippines (15%). Therefore, it has been suggested to consider genetic testing in these people prior to initiation of treatment.
caption: Trileptal (oxcarbazepine), oral suspension 100 mg/ml
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