page_title: Zuclopenthixol
section_title: Pharmacodynamics
hierarchical_section_title: Zuclopenthixol / Pharmacology / Pharmacodynamics
caption_attribution_description: Svenska: Cisordinol (zuclopenthixol) tablets
context_page_description: Zuclopenthixol, also known as zuclopentixol, is a medication used to treat schizophrenia and other psychoses. It is classed, pharmacologically, as a typical antipsychotic. Chemically it is a thioxanthene. It is the cis-isomer of clopenthixol. Clopenthixol was introduced in 1961, while zuclopenthixol was introduced in 1978.
  Zuclopenthixol is a D₁ and D₂ antagonist, α₁-adrenergic and 5-HT₂ antagonist. While it is approved for use in Australia, Canada, Ireland, India, New Zealand, Singapore, South Africa and the UK it is not approved for use in the United States.
context_section_description: Zuclopenthixol antagonises both dopamine D₁ and D₂ receptors, α₁-adrenoceptors and 5-HT₂ receptors with a high affinity, but has no affinity for cholinergic muscarine receptors. It weakly antagonises the histamine (H₁) receptor but has no α₂-adrenoceptor blocking activity.
  Evidence from in vitro work and clinical sources (i.e. therapeutic drug monitoring databases) suggests that both CYP2D6 and CYP3A4 play important roles in zuclopenthixol metabolism.
caption: Cisordinol 10 mg tablet
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