page_title: List of dangerous snakes
section_title: Philippine cobra
hierarchical_section_title: List of dangerous snakes / Highly dangerous / True cobras / Philippine cobra
caption_attribution_description: English: A Philippines cobra in a defensive posture.
context_page_description: Of the 3,500 snake species, there are around 600 venomous snake species in the world. This is an overview of the snakes that pose a significant health risk to humans, through snakebites or other physical trauma.
  The varieties of snakes that most often cause serious snakebites depend on the region of the world. In Africa, the most dangerous species include black mambas, puff adders, and carpet vipers. In the Middle East the species of greatest concern are carpet vipers and elapids; in Central and South America, Bothrops and Crotalus are of greatest concern. In South Asia, it has historically been believed that Indian cobras, common kraits, Russell's viper and carpet vipers were the most dangerous species; however other snakes may also cause significant problems in this area of the world. While several species of snakes may cause more bodily destruction than others, any of these venomous snakes are still very capable of causing human fatalities should a bite go untreated, regardless of their venom capabilities or behavioral tendencies.
context_section_description: The Philippine cobra (Naja philippinensis) is one of the most venomous cobra species in the world based on murine LD₅₀ studies. The average subcutaneous LD₅₀ for this species is 0.20 mg/kg. The lowest LD₅₀ reported value for this snake is 0.14 mg/kg SC, while the highest is 0.48 mg/kg SC. and the average venom yield per bite is 90–100 mg. The venom of the Philippine cobra is a potent postsynaptic neurotoxin which affects respiratory function and can cause neurotoxicity and respiratory paralysis, as the neurotoxins interrupt the transmission of nerve signals by binding to the neuromuscular junctions near the muscles. Research has shown its venom is purely a neurotoxin, with no apparent necrotizing components and no cardiotoxins. These snakes are capable of accurately spitting their venom at a target up to 3 metres (9.8 ft) away. Bites from this species produce prominent neurotoxicity and are considered especially dangerous. A study of 39 patients envenomed by the Philippine cobra was conducted in 1988. Neurotoxicity occurred in 38 cases and was the predominant clinical feature. Complete respiratory failure developed in 19 patients,and was often rapid in onset; in three cases, apnea occurred within just 30 minutes of the bite. There were two deaths, both in patients who were moribund upon arrival at the hospital. Three patients developed necrosis, and 14 individuals with systemic symptoms had no local swelling at all. Both cardiotoxicity and reliable nonspecific signs of envenoming were absent. Bites by the Philippine cobra produce a distinctive clinical picture characterized by severe neurotoxicity of rapid onset and minimal local tissue damage.
caption: Philippine cobra (naja philippinensis)
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