page_title: Low-density lipoprotein receptor gene family
hierarchical_section_title: Low-density lipoprotein receptor gene family
caption_attribution_description: বাংলা: 1n7d কোডসহ নিবন্ধিত প্রোটিনের আণবিক গঠনের কার্টুন উপস্থাপনা। English: Cartoon representation of the molecular structure of protein registered with 1n7d code. Deutsch: Grafik des Molekularstruktur von jenem Protein, das mit 1n7d code registriert ist. Plattdüütsch: Grafik, de de Molekularstruktur von dat Protein wiest, dat mit’n Kood 1n7d registreert is.
context_page_description: The low-density lipoprotein receptor gene family codes for a class of structurally related cell surface receptors that fulfill diverse biological functions in different organs, tissues, and cell types. The role that is most commonly associated with this evolutionarily ancient family is cholesterol homeostasis. In humans, excess cholesterol in the blood is captured by low-density lipoprotein and removed by the liver via endocytosis of the LDL receptor. Recent evidence indicates that the members of the LDL receptor gene family are active in the cell signalling pathways between specialized cells in many, if not all, multicellular organisms.
  There are seven members of the LDLR family in mammals, namely:
  LDLR
  VLDL receptor
  ApoER2, or LRP8
  Low density lipoprotein receptor-related protein 4
  also known as multiple epidermal growth factor repeat-containing protein
  LDLR-related protein 1
  LDLR-related protein 1b
  Megalin.
context_section_description: The low-density lipoprotein receptor gene family codes for a class of structurally related cell surface receptors that fulfill diverse biological functions in different organs, tissues, and cell types. The role that is most commonly associated with this evolutionarily ancient family is cholesterol homeostasis (maintenance of appropriate concentration of cholesterol). In humans, excess cholesterol in the blood is captured by low-density lipoprotein (LDL) and removed by the liver via endocytosis of the LDL receptor. Recent evidence indicates that the members of the LDL receptor gene family are active in the cell signalling pathways between specialized cells in many, if not all, multicellular organisms.
  There are seven members of the LDLR family in mammals, namely:
  LDLR
  VLDL receptor (VLDLR)
  ApoER2, or LRP8
  Low density lipoprotein receptor-related protein 4
  also known as multiple epidermal growth factor (EGF) repeat-containing protein (MEGF7)
  LDLR-related protein 1
  LDLR-related protein 1b
  Megalin.
caption: Structure of the LDL receptor extracellular domain at endosomal pH.[2]
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