page_title: St. Louis
section_title: Major companies and institutions
hierarchical_section_title: St. Louis / Economy / Major companies and institutions
caption_attribution_description: Jefferson Lake in Forest Park in St. Louis, looking toward Barnes-Jewish Hospital.
context_page_description: St. Louis is a city in Missouri, on the western bank of the Mississippi River, which forms the state line between Illinois and Missouri. The Missouri River merges with the Mississippi River 15 river miles north of Downtown St. Louis, forming the fourth-longest river system in the world. In 2019, the estimated population was 300,576, and of the bi-state metropolitan area, 2,804,724. Greater St. Louis is the largest metropolitan area in Missouri, second-largest in Illinois, seventh-largest in the Great Lakes Megalopolis, and the 22nd-largest in the United States.
  Before European settlement, the area was a regional center of Native American Mississippian culture. The city of St. Louis was founded in 1764 by French fur traders Pierre Laclède and Auguste Chouteau, and named after Louis IX of France. In 1764, following France's defeat in the Seven Years' War, the area was ceded to Spain. In 1800, it was retroceded to France, which sold it three years later to the United States as part of the Louisiana Purchase. In the 19th century, St. Louis became a major port on the Mississippi River; in 1870, it was the fourth-largest city in the country. It separated from St.
context_section_description: As of 2018, the St. Louis Metropolitan Area is home to ten Fortune 500 companies, the 7th-most among U.S. cities. They include Express Scripts, Emerson Electric, Monsanto, Reinsurance Group of America, Centene, Graybar Electric, and Edward Jones Investments.
  Other notable corporations headquartered in the region include Arch Coal, Bunge Limited, Wells Fargo Advisors (formerly A.G. Edwards), Energizer Holdings, Patriot Coal, Post Foods, United Van Lines, and Mayflower Transit, Post Holdings, Olin, and Enterprise Holdings (a parent company of several car rental companies). Notable corporations with operations in St. Louis include Cassidy Turley, Kerry Group, Mastercard, TD Ameritrade, and BMO Harris Bank.
  Health care and biotechnology institutions with operations in St. Louis include Pfizer, the Donald Danforth Plant Science Center, the Solae Company, Sigma-Aldrich, and Multidata Systems International. General Motors manufactures automobiles in Wentzville, while an earlier plant, known as the St. Louis Truck Assembly, built GMC automobiles from 1920 until 1987. Chrysler closed its St. Louis Assembly production facility in nearby Fenton, Missouri and Ford closed the St. Louis Assembly Plant in Hazelwood.
  Several once-independent pillars of the local economy have been purchased by other corporations. Among them are Anheuser-Busch, purchased by Belgium-based InBev; Missouri Pacific Railroad, which was headquartered in St. Louis, merged with the Omaha, Nebraska-based Union Pacific Railroad in 1982; McDonnell Douglas, whose operations are now part of Boeing Defense, Space & Security; Trans World Airlines, which was headquartered in the city for its last decade of existence, prior to being acquired by American Airlines; Mallinckrodt, purchased by Tyco International; and Ralston Purina, now a wholly owned subsidiary of Nestlé. The May Department Stores Company (which owned Famous-Barr and Marshall Field's stores) was purchased by Federated Department Stores, which has its regional headquarters in the area. The Federal Reserve Bank of St. Louis in downtown is one of two federal reserve banks in Missouri. Most of the assets of Furniture Brands International were sold to Heritage Home Group in 2013, which moved to North Carolina.
  St. Louis is a center of medicine and biotechnology. The Washington University School of Medicine is affiliated with Barnes-Jewish Hospital, the fifth largest hospital in the world. Both institutions operate the Alvin J. Siteman Cancer Center. The School of Medicine also is affiliated with St. Louis Children's Hospital, one of the country's top pediatric hospitals. Both hospitals are owned by BJC HealthCare. The McDonnell Genome Institute at Washington University played a major role in the Human Genome Project. St. Louis University Medical School is affiliated with SSM Health's Cardinal Glennon Children's Hospital and St. Louis University Hospital. It also has a cancer center, vaccine research center, geriatric center, and a bioethics institute. Several different organizations operate hospitals in the area, including BJC HealthCare, Mercy, SSM Health Care, and Tenet.
  Cortex Innovation Community in Midtown neighborhood is the largest innovation hub in the midwest. Cortex is home to offices of Square, Microsoft, Aon, Boeing, and Centene. Cortex has generated 3,800 tech jobs in 14 years. Once built out, projections are for it to make $2 billion in development and create 13,000 jobs for the region.
  Boeing employs nearly 15,000 people in its north St. Louis campus, headquarters to its defense unit. In 2013, the company said it would move about 600 jobs from Seattle, where labor costs have risen, to a new IT center in St. Louis.  Other companies, such as LaunchCode and LockerDome, think the city could become the next major tech hub.  Programs such as Arch Grants are attracting new startups to the region.
  According to the St. Louis Business Journal, the top employers in the St. Louis metropolitan area as of 1 May 2017, are:
  According to St. Louis's 2017 Comprehensive Annual Financial Report (June 30), the top empl
caption: Barnes-Jewish Hospital, which is affiliated with the Washington University School of Medicine
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