page_title: Isotopic resonance hypothesis
section_title: Experimental verification
hierarchical_section_title: Isotopic resonance hypothesis / Experimental verification
caption_attribution_description: English: IsoRes
context_page_description: The isotopic resonance hypothesis postulates that certain isotopic compositions of chemical elements affect kinetics of chemical reactions involving molecules built of these elements. The isotopic compositions for which this effect is predicted are called resonance isotopic compositions.
  Fundamentally, the IsoRes hypothesis relies on a postulate that less complex systems exhibit faster kinetics than equivalent but more complex systems. Furthermore, system’s complexity is affected by its symmetry, and symmetry of reactants may be affected by their isotopic composition.
  The term “resonance” relates to the use of this term in nuclear physics, where peaks in the dependence of a reaction cross section upon energy are called “resonances”. Similarly, a sharp increase in the reaction kinetics as a function of the average isotopic mass of a certain element is called here a resonance.
context_section_description: The IsoRes hypothesis has been tested experimentally by means of growth of E. coli and found to be supported by extremely strong statistics (p << 10⁻¹⁵). Particular strong evidence of faster growth was found for the “super-resonance”.
  Fig. 1. 2D plot of molecular masses of 3000 E. coli tryptic peptides. A – terrestrial isotopic compositions (red arrow shows the line representing the resonance); B – ¹⁸O abundance is increased by 20%, which destroyed the terrestrial resonance; C – isotopic compositions of the “super-resonance”, where all dots (molecules) are perfectly aligned. Adapted from ref. 4.
caption: Fig1
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