page_title: List of skin conditions
section_title: Abnormalities of dermal fibrous and elastic tissue
hierarchical_section_title: List of skin conditions / Connective tissue diseases / Abnormalities of dermal fibrous and elastic tissue
caption_attribution_description: Stretchmarks on the abdomen of an obese adult male.
context_page_description: Many conditions affect the human integumentary system—the organ system covering the entire surface of the body and composed of skin, hair, nails, and related muscle and glands. The major function of this system is as a barrier against the external environment. The skin weighs an average of four kilograms, covers an area of two square metres, and is made of three distinct layers: the epidermis, dermis, and subcutaneous tissue. The two main types of human skin are: glabrous skin, the hairless skin on the palms and soles, and hair-bearing skin. Within the latter type, the hairs occur in structures called pilosebaceous units, each with hair follicle, sebaceous gland, and associated arrector pili muscle. In the embryo, the epidermis, hair, and glands form from the ectoderm, which is chemically influenced by the underlying mesoderm that forms the dermis and subcutaneous tissues.
  The epidermis is the most superficial layer of skin, a squamous epithelium with several strata: the stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum, and stratum basale. Nourishment is provided to these layers by diffusion from the dermis, since the epidermis is without direct blood supply.
context_section_description: Abnormalities of dermal fibrous and elastic tissue are caused by problems in the regulation of collagen synthesis or degradation.
  Acrodermatitis chronica atrophicans (Herxheimer disease, primary diffuse atrophy)
  Actinic elastosis (solar elastosis)
  Anetoderma (anetoderma maculosa, anetoderma maculosa cutis, atrophia maculosa cutis, macular atrophy)
  Blepharochalasis
  Cutis laxa (chalazoderma, dermatochalasia, dermatolysis, dermatomegaly, generalized elastolysis, generalized elastorrhexis, pachydermatocele)
  Cutis rhomboidalis nuchae
  Ehlers–Danlos syndrome (cutis hyperelastica, elastic skin, India rubber skin)
  Elastosis perforans serpiginosa
  Homocystinuria
  Jadassohn–Pellizzari anetoderma
  Linear focal elastosis (elastotic striae)
  Loeys–Dietz syndrome
  Marfan syndrome
  Occipital horn syndrome
  Osteogenesis imperfecta (Lobstein syndrome)
  Perforating calcific elastosis (localized acquired cutaneous pseudoxanthoma elasticum, perforating periumbilical calcific elastosis, periumbilical perforating pseudoxanthoma elasticum)
  Pseudoxanthoma elasticum (Grönblad–Strandberg syndrome)
  Reactive perforating collagenosis
  Schweninger–Buzzi anetoderma
  Sclerotic fibroma
  Striae atrophicans
  Striae distensae
  Ullrich disease
  Verrucous perforating collagenoma
  Wrinkly skin syndrome
caption: Striae distensae
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