page_title: Salt bridge (protein and supramolecular)
section_title: Supramolecular chemistry
hierarchical_section_title: Salt bridge (protein and supramolecular) / Supramolecular chemistry
caption_attribution_description: English: Yes
context_page_description: In chemistry, a salt bridge is a combination of two non-covalent interactions: hydrogen bonding and ionic bonding. Ion pairing is one of the most important noncovalent forces in chemistry, in biological systems, in different materials and in many applications such as ion pair chromatography. It is a most commonly observed contribution to the stability to the entropically unfavorable folded conformation of proteins. Although noncovalent interactions are known to be relatively weak interactions, small stabilizing interactions can add up to make an important contribution to the overall stability of a conformer. Not only are salt bridges found in proteins, but they can also be found in supramolecular chemistry. The thermodynamics of each are explored through experimental procedures to access the free energy contribution of the salt bridge to the overall free energy of the state.
context_section_description: Supramolecular chemistry is a field concerned with non-covalent interactions between macromolecules. Salt bridges have been used by chemists within this field in both diverse and creative ways, including sensing of anions, the synthesis of molecular capsules and double helical polymers.
caption: Figure 7. Interlacing salt bridges that connect the two halves of the molecular capsule.
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