page_title: AB5 toxin
section_title: Families
hierarchical_section_title: AB5 toxin / Families
caption_attribution_description: English: Cartoon representation of the molecular structure of pertussis toxin. It is composed of 5 kinds of subuints. S1: green S2: cyan S3: purple S4: yellow (double) S5: red This file was created from pdb file id = 1pdb.
context_page_description: The AB₅ toxins are six-component protein complexes secreted by certain pathogenic bacteria known to cause human diseases such as cholera, dysentery, and hemolytic–uremic syndrome. One component is known as the A subunit, and the remaining five components are B subunits. All of these toxins share a similar structure and mechanism for entering targeted host cells. The B subunit is responsible for binding to receptors to open up a pathway for the A subunit to enter the cell. The A subunit is then able to use its catalytic machinery to take over the host cell's regular functions.
context_section_description: There are four main families of the AB5 toxin. These families are characterized by the sequence of their A (catalytic) subunit, as well as their catalytic ability.
caption: Ribbon diagram of pertussis toxin. S1 is the A subunit, and S2-S5 make up the B subunit.[3]
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