page_title: Glycerate dehydrogenase
hierarchical_section_title: Glycerate dehydrogenase
caption_attribution_description: English: Glyoxylate Reductase/Hydroxypyruvate Reductase. Quaternary structure of 2 homodimers of GRHPR.
context_page_description: In enzymology, a glycerate dehydrogenase is an enzyme that catalyzes the chemical reaction
  -glycerate + NAD⁺ hydroxypyruvate + NADH + H⁺
  Thus, the two substrates of this enzyme are-glycerate and NAD⁺, whereas its 3 products are hydroxypyruvate, NADH, and H⁺. However, in nature these enzymes have the ability to catalyze the reverse reaction as well. That is, hydroxypyruvate, NADH, and H⁺ can act as the substrates while-glycerate and NAD⁺ are formed as products. Additionally, NADPH can take the place of NADH in this reaction.
  This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is-glycerate:NAD⁺ oxidoreductase. Other names in common use include D-glycerate dehydrogenase, and hydroxypyruvate reductase. This enzyme participates in glycine, serine and threonine metabolism and glyoxylate and dicarboxylate metabolism.
context_section_description: In enzymology, a glycerate dehydrogenase (EC 1.1.1.29) is an enzyme that catalyzes the chemical reaction
  (D)-glycerate + NAD⁺  hydroxypyruvate + NADH + H⁺
  Thus, the two substrates of this enzyme are (R)-glycerate and NAD⁺, whereas its 3 products are hydroxypyruvate, NADH, and H⁺. However, in nature these enzymes have the ability to catalyze the reverse reaction as well. That is, hydroxypyruvate, NADH, and H⁺ can act as the substrates while (R)-glycerate and NAD⁺ are formed as products. Additionally, NADPH can take the place of NADH in this reaction.
  This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-glycerate:NAD⁺ oxidoreductase. Other names in common use include D-glycerate dehydrogenase, and hydroxypyruvate reductase (due to the reversibility of the reaction). This enzyme participates in glycine, serine and threonine metabolism and glyoxylate and dicarboxylate metabolism.
caption: Glyoxylate reductase/Hydroxypyruvate reductase. Quaternary structure of 2 homodimers of GRHPR bound to NADPH and (D)-glycerate.
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