Document:

EX-10.21

 Exhibit 10.21 

NEOTHETICS, INC. 
 NOTICE
OF GRANT OF RESTRICTED STOCK UNITS 
 Neothetics, Inc. (the “Company”) has granted to the Participant an award
(the “Award”) of certain units pursuant to the Neothetics, Inc. 2014 Equity Incentive Plan (the “Plan”), each of which represents the right to receive on the applicable
Settlement Date one (1) share of Stock, as follows: 
  

							
	Participant:	  	  
	  	Employee ID:	  	  

			
	Date of Grant:	  	  
	  	
		
	Total Number of Units:	  	            , subject to adjustment as provided by the Restricted Stock Units Agreement.
		
	Settlement Date:	  	As soon as practicable on or after the date on which a Unit becomes a Vested Unit, but no later than March 15th of the calendar year following the year in which the
Unit becomes a Vested Unit..
			
	Vesting Commencement Date:	  	  
	  	
		
	Vested Units:	  	Except as provided in the Restricted Stock Units Agreement and provided that the Participant’s Service has not terminated prior to the applicable date, the number of Vested Units (disregarding any resulting
fractional Unit) as of any date is determined by multiplying the Total Number of Units by the “Vested Ratio” determined as of such date, as follows:

 

					
	 	  	Vested Ratio	 
		
	 Prior to first anniversary of Vesting Commencement Date
	  	 	0	  
		
	 INSERT VESTING SCHEDULE
	  			

  

							
	Superseding Agreement:	  	[None] [Title and Date of Employment Agreement]
		
		  	The terms and conditions of the Superseding Agreement shall, notwithstanding any provision of the Restricted Stock Units Agreement to the contrary, supersede any inconsistent term or condition set forth in the Restricted
Stock Units Agreement to the extent intended by such Superseding Agreement.

 By their signatures below or by electronic acceptance or authentication in a form authorized by the Company, the Company and
the Participant agree that the Award is governed by this Grant Notice and by the provisions of the Plan and the Restricted Stock Units Agreement, both of which are made a part of this document. The Participant represents that the Participant has
read and is familiar with the provisions of the Plan and Restricted Stock Units Agreement, and hereby accepts the Award subject to all of their terms and conditions. 
  

							
	NEOTHETICS, INC.	 		 	PARTICIPANT
				
	By:	 	  
	 		 	  

		 	[officer name]	 		 	Signature
		 	[officer title]	 		 	  

		 		 		 	Date
	Address:	 	  
	 		 	  

		 		 		 	AddressEX-10.22

 Exhibit 10.22 

NEOTHETICS, INC. 
 NOTICE
OF GRANT OF RESTRICTED STOCK 
 The Participant has been granted a Restricted Stock Award (the “Award”) pursuant
to the Neothetics, Inc. 2014 Equity Incentive Plan (the “Plan”) of certain shares of Stock of the Neothetics, Inc. (the “Shares”), as follows: 

 

							
	Participant:	  	  
	  	Employee ID:	  	  

				
	Date of Grant:	  	  
	  		  	
		
	Total Number of Shares:	  	            , subject to adjustment as provided by the Restricted Stock Agreement.
				
	Fair Market Value per Share on Grant Date:	  	$                                     
          	  		  	
		
	Vested Shares:	  	Except as provided in the Restricted Stock Agreement and provided that the Participant’s Service has not terminated prior to the applicable date, the number of Vested Shares shall cumulatively increase on each
respective date set forth below by the number of shares set forth opposite such date, as follows:

  

			
	 Vesting Date
	  	Number of Shares Vesting
		  	
		  	
		  	

  

							
	Superseding Agreement:	  	[None] [Name of applicable agreement]
		
		  	The terms and conditions of the foregoing Superseding Agreement (if any) to which the Participant is a party shall, notwithstanding any provision of the Restricted Stock Agreement to the contrary, supersede any
inconsistent term or condition set forth in the Restricted Stock Agreement to the extent intended by such Superseding Agreement.

 By their signatures below or by electronic acceptance or authentication in a form authorized by the Company, the Company and
the Participant agree that the Award is governed by this Grant Notice and by the provisions of the Plan and the Restricted Stock Agreement, both of which are made part of this document. The Participant represents that the Participant has read and is
familiar with the provisions of the Plan and the Restricted Stock Agreement, and hereby accepts the Award subject to all of their terms and conditions. 
  

							
	NEOTHETICS, INC.	 		 	PARTICIPANT
				
	By:	 	  
	 		 	  

		 	[officer name]	 		 	Signature
		 	[officer title]	 		 	  

		 		 		 	Date
	Address:	 	  
	 		 	  

		 		 		 	AddressEX-10.23

 Exhibit 10.23 

NEOTHETICS, INC. 
 NOTICE
OF GRANT OF STOCK OPTION 
 The Neothetics, Inc. (the “Company”) has granted to the Participant an option (the
“Option”) to purchase certain shares of Stock of the Company pursuant to the Neothetics, Inc. 2014 Equity Incentive Plan (the “Plan”), as follows: 

 

							
	Participant:	  	  
	  	Employee ID:	  	  

			
	Date of Grant:	  	  
	  	
		
	Number of Option Shares:	  	            , subject to adjustment as provided by the Option Agreement.
				
	Exercise Price:	  	$                                     
          	  		  	
			
	Initial Vesting Date:	  	  
	  	
			
	Option Expiration Date:	  	  
	  	
		
	Tax Status of Option:	  	             Stock Option. (Enter “Incentive” or “Nonstatutory.” If blank, this Option will be a Nonstatutory Stock Option.)
		
	Vested Shares:	  	Except as provided in the Option Agreement, the number of Vested Shares (disregarding any resulting fractional share) as of any date is determined by multiplying the Number of Option Shares by the
“Vested Ratio” determined as of such date as follows:

  

					
	 	  	Vested Ratio	 
		
	 Prior to Initial Vesting Date
	  	 	0	  
		
	 INSERT VESTING SCHEDULE
	  			

  

							
	Superseding Agreement:	  	[None] [Name of applicable agreement]
		
		  	The terms and conditions of the foregoing Superseding Agreement (if any) to which the Participant is a party shall, notwithstanding any provision of the Option Agreement to the contrary, supersede any inconsistent term
or condition set forth in the Option Agreement to the extent intended by such Superseding Agreement.

 By their signatures below or by electronic acceptance or authentication in a form authorized by the Company, the Company and
the Participant agree that the Option is governed by this Grant Notice and by the provisions of the Plan and the Option Agreement, both of which are made a part of this document. The Participant represents that the Participant has read and is
familiar with the provisions of the Plan and the Option Agreement, and hereby accepts the Option subject to all of their terms and conditions. 
  

							
	NEOTHETICS, INC.	 		 	PARTICIPANT
				
	By:	 	  
	 		 	  

		 	[officer name]	 		 	Signature
		 	[officer title]	 		 	  

		 		 		 	Date
	Address:	 	  
	 		 	  

		 		 		 	AddressEX-10.24

 Exhibit 10.24 

Neothetics, Inc. 
 2014
EMPLOYEE STOCK 
 PURCHASE PLAN 

 Neothetics, Inc. 

2014 Employee Stock Purchase Plan 
  

	 	1.	ESTABLISHMENT, PURPOSE AND TERM OF PLAN. 

1.1 Establishment. The Neothetics, Inc. 2014 Employee Stock Purchase Plan (the “Plan”) is hereby
established effective as of the effective date of the initial registration by the Company of its Stock under Section 12 of the Securities Exchange Act of 1934, as amended (the “Effective Date”). 

1.2 Purpose. The purpose of the Plan is to advance the interests of the Company and its stockholders by providing an incentive to
attract, retain and reward Eligible Employees of the Participating Company Group and by motivating such persons to contribute to the growth and profitability of the Participating Company Group. The Plan provides such Eligible Employees with an
opportunity to acquire a proprietary interest in the Company through the purchase of Stock. The Company intends that the Plan qualify as an “employee stock purchase plan” under Section 423 of the Code (including any amendments or
replacements of such section), and the Plan shall be so construed. 
 1.3 Term of Plan. The Plan shall continue in effect until its
termination by the Committee. 
  

	 	2.	DEFINITIONS AND CONSTRUCTION. 

2.1 Definitions. Any term not expressly defined in the Plan but defined for purposes of Section 423 of the Code shall have the same
definition herein. Whenever used herein, the following terms shall have their respective meanings set forth below: 
 (a)
“Board” means the Board of Directors of the Company. 
 (b) “Cash Exercise
Notice” means a written notice in such form as specified by the Company which states a Participant’s election to exercise, as of the next Purchase Date, a Purchase Right granted to such Participant with respect to a
Pre-Registration Offering Period. 
 (c) “Change in Control” means the occurrence of any one or a
combination of the following: 
 (i) any “person” (as such term is used in Sections 13(d) and 14(d) of the Exchange Act)
becomes the “beneficial owner” (as such term is defined in Rule 13d-3 promulgated under the Exchange Act), directly or indirectly, of securities of the Company representing more than fifty
percent (50%) of the total Fair Market Value or total combined voting power of the Company’s then-outstanding securities entitled to vote generally in the election of Directors; provided, however,
that a Change in Control shall not be deemed to have occurred if such degree of beneficial ownership results from any of the following: (A) an acquisition by any person who on the Effective Date is the beneficial owner of more than fifty

  
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percent (50%) of such voting power, (B) any acquisition directly from the Company, including, without limitation, pursuant to or in connection with a public offering of securities,
(C) any acquisition by the Company, (D) any acquisition by a trustee or other fiduciary under an employee benefit plan of a Participating Company or (E) any acquisition by an entity owned directly or indirectly by the stockholders of
the Company in substantially the same proportions as their ownership of the voting securities of the Company; or 
 (ii) an Ownership
Change Event or series of related Ownership Change Events (collectively, a “Transaction”) in which the stockholders of the Company immediately before the Transaction do not retain immediately after the
Transaction direct or indirect beneficial ownership of more than fifty percent (50%) of the total combined voting power of the outstanding securities entitled to vote generally in the election of Directors or, in the case of an Ownership Change
Event described in Section 2.1(q)(iii), the entity to which the assets of the Company were transferred (the “Transferee”), as the case may be; or 

(iii) a date specified by the Committee following approval by the stockholders of a plan of complete liquidation or dissolution of the
Company; 
 provided, however, that a Change in Control shall be deemed not to include a transaction described in subsections (i) or (ii) of this
Section 2.1(c) in which a majority of the members of the board of directors of the continuing, surviving or successor entity, or parent thereof, immediately after such transaction is comprised of Incumbent Directors. 

For purposes of the preceding sentence, indirect beneficial ownership shall include, without limitation, an interest resulting from ownership
of the voting securities of one or more corporations or other business entities which own the Company or the Transferee, as the case may be, either directly or through one or more subsidiary corporations or other business entities. The Committee
shall determine whether multiple events described above are related and to be treated in the aggregate as a single Change in Control, and its determination shall be final, binding and conclusive. 

(d) “Code” means the Internal Revenue Code of 1986, as amended, and any applicable regulations
promulgated thereunder. 
 (e) “Committee” means the Compensation Committee and such other committee
or subcommittee of the Board, if any, duly appointed to administer the Plan and having such powers in each instance as shall be specified by the Board. If, at any time, there is no committee of the Board then authorized or properly constituted to
administer the Plan, the Board shall exercise all of the powers of the Committee granted herein, and, in any event, the Board may in its discretion exercise any or all of such powers. 

(f) “Company” means the Neothetics, Inc., a Delaware corporation, or any successor corporation thereto.

 (g) “Compensation” means, with respect to any Offering Period, base wages or salary, overtime,
bonuses, commissions, shift differentials, payments for paid time off, payments in lieu of notice, and compensation deferred under any program or plan, including, without limitation, pursuant to Section 401(k) or Section 125 of the Code.
Compensation shall 

  
 2 

 
be limited to amounts actually payable in cash or deferred during the Offering Period. Compensation shall not include moving allowances, payments pursuant to a severance agreement, termination
pay, relocation payments, sign-on bonuses, any amounts directly or indirectly paid pursuant to the Plan or any other stock purchase, stock option or other stock-based compensation plan, or any other compensation not included above. 

(h) “Eligible Employee” means an Employee who meets the requirements set forth in Section 5 for
eligibility to participate in the Plan. 
 (i) “Employee” means a person treated as an employee of a
Participating Company for purposes of Section 423 of the Code. A Participant shall be deemed to have ceased to be an Employee either upon an actual termination of employment or upon the corporation employing the Participant ceasing to be a
Participating Company. For purposes of the Plan, an individual shall not be deemed to have ceased to be an Employee while on any military leave, sick leave, or other bona fide leave of absence approved by the Company of ninety (90) days or
less. If an individual’s leave of absence exceeds ninety (90) days, the individual shall be deemed to have ceased to be an Employee on the ninety-first (91st) day of such leave unless the individual’s right to reemployment with
the Participating Company Group is guaranteed either by statute or by contract. 
 (j) “Fair Market
Value” means, as of any date: 
 (i) Except as otherwise determined by the Committee, if, on such date, the Stock is
listed or quoted on a national or regional securities exchange or quotation system, the closing price of a share of Stock as quoted on the national or regional securities exchange or quotation system constituting the primary market for the Stock, as
reported in The Wall Street Journal or such other source as the Company deems reliable. If the relevant date does not fall on a day on which the Stock has traded on such securities exchange or quotation system, the date on which the Fair
Market Value is established shall be the last day on which the Stock was so traded or quoted prior to the relevant date, or such other appropriate day as determined by the Committee, in its discretion. 

(ii) If, on the relevant date, the Stock is not then listed on a national or regional securities exchange or quotation system, the Fair
Market Value of a share of Stock shall be as determined in good faith by the Committee. 
 (iii) Notwithstanding the foregoing, if a
Pre-Registration Offering Period commences on the Effective Date, then the Fair Market Value of a share of Stock on such date shall be deemed to be the public offering price set forth in the final prospectus filed with the Securities and Exchange
Commission in connection with the Company’s initial public offering of the Stock. 
 (k) “Incumbent
Director” means a director who either (i) is a member of the Board as of the Effective Date, or (ii) is elected, or nominated for election, to the Board with the affirmative votes of at least a majority of the Incumbent
Directors at the time of such election or nomination (but excluding a director who was elected or nominated in connection with an actual or threatened proxy contest relating to the election of directors of the Company). 

  
 3 

 (l) “Non-United States Offering” means a separate Offering
covering Eligible Employees of one or more Participating Companies whose Eligible Employees are subject to a prohibition under applicable law on payroll deductions, as described in Section 11.1(c). 

(m) “Offering” means an offering of Stock pursuant to the Plan, as provided in Section 6. 

(n) “Offering Date” means, for any Offering Period, the first day of such Offering Period. 

(o) “Offering Period” means a period, established by the Committee in accordance with Section 6,
during which an Offering is outstanding. 
 (p) “Officer” means any person designated by the Board as
an officer of the Company. 
 (q) “Ownership Change Event” means the occurrence of any of the
following with respect to the Company: (i) the direct or indirect sale or exchange in a single or series of related transactions by the stockholders of the Company of securities of the Company representing more than fifty percent (50%) of
the total combined voting power of the Company’s then outstanding securities entitled to vote generally in the election of Directors; (ii) a merger or consolidation in which the Company is a party; or (iii) the sale, exchange, or
transfer of all or substantially all of the assets of the Company (other than a sale, exchange or transfer to one or more subsidiaries of the Company). 

(r) “Parent Corporation” means any present or future “parent corporation” of the Company, as
defined in Section 424(e) of the Code. 
 (s) “Participant” means an Eligible Employee who has
become a participant in an Offering Period in accordance with Section 7 and remains a participant in accordance with the Plan. 
 (t)
“Participating Company” means the Company and any Parent Corporation or Subsidiary Corporation designated by the Committee as a corporation the Employees of which may, if Eligible Employees, participate in the
Plan. The Committee shall have the discretion to determine from time to time which Parent Corporations or Subsidiary Corporations shall be Participating Companies. 

(u) “Participating Company Group” means, at any point in time, the Company and all other corporations
collectively which are then Participating Companies. 
 (v) “Pre-Registration Offering Period” means
an Offering Period commencing prior to the Registration Date with respect to the shares of Stock issuable pursuant to such Offering Period. 

  
 4 

 (w) “Purchase Date” means, for any Offering Period, the
last day of such Offering Period, or, if so determined by the Committee, the last day of each Purchase Period occurring within such Offering Period. 

(x) “Purchase Period” means a period, established by the Committee in accordance with Section 6,
included within an Offering Period and on the final date of which outstanding Purchase Rights are exercised. 
 (y)
“Purchase Price” means the price at which a share of Stock may be purchased under the Plan, as determined in accordance with Section 9. 

(z) “Purchase Right” means an option granted to a Participant pursuant to the Plan to purchase such
shares of Stock as provided in Section 8, which the Participant may or may not exercise during the Offering Period in which such option is outstanding. Such option arises from the right of a Participant to withdraw any payroll deductions or
other funds accumulated on behalf of the Participant and not previously applied to the purchase of Stock under the Plan, and to terminate participation in the Plan at any time during an Offering Period. 

(aa) “Registration Date” means the effective date of the registration on Form S-8 of shares of Stock
issuable pursuant to the Plan. 
 (bb) “Securities Act” means the Securities Act of 1933, as amended.

 (cc) “Stock” means the common stock of the Company, as adjusted from time to time in accordance
with Section 4.3. 
 (dd) “Subscription Agreement” means a written or electronic agreement, in
such form as is specified by the Company, stating an Employee’s election to participate in the Plan and authorizing payroll deductions under the Plan from the Employee’s Compensation or other method of payment authorized by the Committee
pursuant to Section 11.1(c). 
 (ee) “Subscription Date” means the last business day prior to
the Offering Date of an Offering Period or such earlier date as the Company shall establish. 
 (ff) “Subsidiary
Corporation” means any present or future “subsidiary corporation” of the Company, as defined in Section 424(f) of the Code. 

2.2 Construction. Captions and titles contained herein are for convenience only and shall not affect the meaning or interpretation of
any provision of the Plan. Except when otherwise indicated by the context, the singular shall include the plural and the plural shall include the singular. Use of the term “or” is not intended to be exclusive, unless the context clearly
requires otherwise. 

  
 5 

	 	3.	ADMINISTRATION. 

 3.1 Administration by the
Committee. The Plan shall be administered by the Committee. All questions of interpretation of the Plan, of any form of agreement or other document employed by the Company in the administration of the Plan, or of any Purchase Right shall be
determined by the Committee, and such determinations shall be final, binding and conclusive upon all persons having an interest in the Plan or the Purchase Right, unless fraudulent or made in bad faith. Subject to the provisions of the Plan, the
Committee shall determine all of the relevant terms and conditions of Purchase Rights; provided, however, that all Participants granted Purchase Rights pursuant to an Offering shall have the same rights and privileges within the meaning of
Section 423(b)(5) of the Code. Any and all actions, decisions and determinations taken or made by the Committee in the exercise of its discretion pursuant to the Plan or any agreement thereunder (other than determining questions of
interpretation pursuant to the second sentence of this Section 3.1) shall be final, binding and conclusive upon all persons having an interest therein. All expenses incurred by the Company in the administration of the Plan shall be paid by the
Company. 
 3.2 Authority of Officers. Any Officer shall have the authority to act on behalf of the Company with respect to any
matter, right, obligation, determination or election that is the responsibility of or that is allocated to the Company herein, provided that the Officer has apparent authority with respect to such matter, right, obligation, determination or
election. 
 3.3 Power to Adopt Sub-Plans or Varying Terms with Respect to Non-U.S. Employees. The Committee shall have the power, in
its discretion, to adopt one or more sub-plans of the Plan as the Committee deems necessary or desirable to comply with the laws or regulations, tax policy, accounting principles or custom of foreign jurisdictions applicable to employees of a
subsidiary business entity of the Company, provided that any such sub-plan shall not be within the scope of an “employee stock purchase plan” within the meaning of Section 423 of the Code. Any of the provisions of any such sub-plan
may supersede the provisions of this Plan, other than Section 4. Except as superseded by the provisions of a sub-plan, the provisions of this Plan shall govern such sub-plan. Alternatively and in order to comply with the laws of a foreign
jurisdiction, the Committee shall have the power, in its discretion, to grant Purchase Rights in an Offering to citizens or residents of a non-U.S. jurisdiction (without regard to whether they are also citizens of the United States or resident
aliens) that provide terms which are less favorable than the terms of Purchase Rights granted under the same Offering to Employees resident in the United States. 

3.4 Power to Establish Separate Offerings with Varying Terms. The Committee shall have the power, in its discretion, to establish
separate, simultaneous or overlapping Offerings having different terms and conditions and to designate the Participating Company or Companies that may participate in a particular Offering, provided that each Offering shall individually comply with
the terms of the Plan and the requirements of Section 423(b)(5) of the Code that all Participants granted Purchase Rights pursuant to such Offering shall have the same rights and privileges within the meaning of such section. 

3.5 Policies and Procedures Established by the Company. Without regard to whether any Participant’s Purchase Right may be
considered adversely affected, the Company 

  
 6 

 
may, from time to time, consistent with the Plan and the requirements of Section 423 of the Code, establish, change or terminate such rules, guidelines, policies, procedures, limitations, or
adjustments as deemed advisable by the Company, in its discretion, for the proper administration of the Plan, including, without limitation, (a) a minimum payroll deduction amount required for participation in an Offering, (b) a limitation
on the frequency or number of changes permitted in the rate of payroll deduction during an Offering, (c) an exchange ratio applicable to amounts withheld or paid in a currency other than United States dollars, (d) a payroll deduction
greater than or less than the amount designated by a Participant in order to adjust for the Company’s delay or mistake in processing a Subscription Agreement or in otherwise effecting a Participant’s election under the Plan or as advisable
to comply with the requirements of Section 423 of the Code, and (e) determination of the date and manner by which the Fair Market Value of a share of Stock is determined for purposes of administration of the Plan. All such actions by the
Company shall be taken consistent with the requirements under Section 423(b)(5) of the Code that all Participants granted Purchase Rights pursuant to an Offering shall have the same rights and privileges within the meaning of such section,
except as otherwise permitted by Section 3.3 and the regulations under Section 423 of the Code. 
 3.6 Indemnification. In
addition to such other rights of indemnification as they may have as members of the Board or the Committee or as officers or employees of the Participating Company Group, to the extent permitted by applicable law, members of the Board or the
Committee and any officers or employees of the Participating Company Group to whom authority to act for the Board, the Committee or the Company is delegated shall be indemnified by the Company against all reasonable expenses, including
attorneys’ fees, actually and necessarily incurred in connection with the defense of any action, suit or proceeding, or in connection with any appeal therein, to which they or any of them may be a party by reason of any action taken or failure
to act under or in connection with the Plan, or any right granted hereunder, and against all amounts paid by them in settlement thereof (provided such settlement is approved by independent legal counsel selected by the Company) or paid by them in
satisfaction of a judgment in any such action, suit or proceeding, except in relation to matters as to which it shall be adjudged in such action, suit or proceeding that such person is liable for gross negligence, bad faith or intentional misconduct
in duties; provided, however, that within sixty (60) days after the institution of such action, suit or proceeding, such person shall offer to the Company, in writing, the opportunity at its own expense to handle and defend the same. 

 

	 	4.	SHARES SUBJECT TO PLAN. 

4.1 Maximum Number of Shares Issuable. Subject to adjustment as provided in Sections 4.2 and 4.3, the maximum aggregate number
of shares of Stock that may be issued under the Plan shall be one hundred seventy thousand (170,000) and shall consist of authorized but unissued or reacquired shares of Stock, or any combination thereof. If an outstanding Purchase Right for any
reason expires or is terminated or canceled, the shares of Stock allocable to the unexercised portion of that Purchase Right shall again be available for issuance under the Plan. 

4.2 Annual Increase in Maximum Number of Shares Issuable. Subject to adjustment as provided in Section 4.3, the maximum aggregate
number of shares of Stock that may be issued under the Plan as set forth in Section 4.1 shall be cumulatively increased automatically on January 1, 2015 and on each subsequent January 1, through and including

  
 7 

 
January 1, 2024, by a number of shares (the “Annual Increase”) equal to the smallest of (a) one percent (1%) of the number of shares of Stock
issued and outstanding on the immediately preceding December 31, or (b) an amount determined by the Board. 
 4.3 Adjustments
for Changes in Capital Structure. Subject to any required action by the stockholders of the Company and the requirements of Section 424 of the Code to the extent applicable, in the event of any change in the Stock effected without receipt
of consideration by the Company, whether through merger, consolidation, reorganization, reincorporation, recapitalization, reclassification, stock dividend, stock split, reverse stock split, split-up, split-off, spin-off, combination of shares,
exchange of shares, or similar change in the capital structure of the Company, or in the event of payment of a dividend or distribution to the stockholders of the Company in a form other than Stock (excepting regular, periodic cash dividends) that
has a material effect on the Fair Market Value of shares of Stock, appropriate and proportionate adjustments shall be made in the number and kind of shares subject to the Plan, the Annual Increase, the limit on the shares which may be purchased by
any Participant during an Offering (as described in Sections 8.1 and 8.2) and each Purchase Right, and in the Purchase Price in order to prevent dilution or enlargement of Participants’ rights under the Plan. For purposes of the foregoing,
conversion of any convertible securities of the Company shall not be treated as “effected without receipt of consideration by the Company.” If a majority of the shares which are of the same class as the shares that are subject to
outstanding Purchase Rights are exchanged for, converted into, or otherwise become (whether or not pursuant to an Ownership Change Event) shares of another corporation (the “New Shares”), the Committee may
unilaterally amend the outstanding Purchase Rights to provide that such Purchase Rights are for New Shares. In the event of any such amendment, the number of shares subject to, and the exercise price per share of, the outstanding Purchase Rights
shall be adjusted in a fair and equitable manner as determined by the Committee, in its discretion. Any fractional share resulting from an adjustment pursuant to this Section shall be rounded down to the nearest whole number, and in no event may the
Purchase Price be decreased to an amount less than the par value, if any, of the stock subject to the Purchase Right. The adjustments determined by the Committee pursuant to this Section 4.3 shall be final, binding and conclusive. 

 

	 	5.	ELIGIBILITY. 

 5.1 Employees Eligible to
Participate. Each Employee of a Participating Company is eligible to participate in the Plan and shall be deemed an Eligible Employee, except the following: 

(a) Any Employee who is customarily employed by the Participating Company Group for twenty (20) hours or less per week; or 

(b) Any Employee who is customarily employed by the Participating Company Group for not more than five (5) months in any calendar year.

 5.2 Exclusion of Certain Stockholders. Notwithstanding any provision of the Plan to the contrary, no Employee shall be treated as
an Eligible Employee and granted a Purchase Right under the Plan if, immediately after such grant, the Employee would own, or hold options to purchase, stock of the Company or of any Parent Corporation or Subsidiary

  
 8 

 
Corporation possessing five percent (5%) or more of the total combined voting power or value of all classes of stock of such corporation, as determined in accordance with
Section 423(b)(3) of the Code. For purposes of this Section 5.2, the attribution rules of Section 424(d) of the Code shall apply in determining the stock ownership of such Employee. 

5.3 Determination by Company. The Company shall determine in good faith and in the exercise of its discretion whether an individual has
become or has ceased to be an Employee or an Eligible Employee and the effective date of such individual’s attainment or termination of such status, as the case may be. For purposes of an individual’s participation in or other rights, if
any, under the Plan as of the time of the Company’s determination of whether or not the individual is an Employee, all such determinations by the Company shall be final, binding and conclusive as to such rights, if any, notwithstanding that the
Company or any court of law or governmental agency subsequently makes a contrary determination as to such individual’s status as an Employee. 
  

	 	6.	OFFERINGS. 

 The Plan shall be implemented by
sequential Offerings of approximately six (6) months duration or such other duration as the Committee shall determine. If so determined by the Committee, a Pre-Registration Offering Period shall commence on the Effective Date and end on such
date established by the Committee prior to the Effective Date. The Committee may establish additional or alternative concurrent, sequential or overlapping Offering Periods, a different duration for one or more Offering Periods or different
commencing or ending dates for such Offering Periods; provided, however, that no Offering Period may have a duration exceeding twenty-seven (27) months. If the Committee shall so determine in its discretion, each Offering Period may consist of
two (2) or more consecutive Purchase Periods having such duration as the Committee shall specify, and the last day of each such Purchase Period shall be a Purchase Date. If the first or last day of an Offering Period or a Purchase Period is not
a day on which the principal stock exchange or quotation system on which the Stock is then listed is open for trading, the Company shall specify the trading day that will be deemed the first or last day, as the case may be, of the Offering Period or
Purchase Period. 
  

	 	7.	PARTICIPATION IN THE PLAN. 

7.1 Initial Participation.  

(a) Generally. Except as provided in Section 7.1(b), an Eligible Employee may become a Participant in an Offering Period by
delivering a properly completed written or electronic Subscription Agreement to the Company office or representative designated by the Company (including a third-party administrator designated by the Company) not later than the close of business on
the Subscription Date established by the Company for that Offering Period. An Eligible Employee who does not deliver a properly completed Subscription Agreement in the manner permitted or required on or before the Subscription Date for an Offering
Period shall not participate in the Plan for that Offering Period or for any subsequent Offering Period unless the Eligible Employee subsequently delivers a properly completed Subscription Agreement to the appropriate Company office or
representative on or before the Subscription Date for such subsequent Offering Period. An Employee who becomes an Eligible 

  
 9 

 
Employee after the Offering Date of an Offering Period shall not be eligible to participate in that Offering Period but may participate in any subsequent Offering Period provided the Employee is
still an Eligible Employee as of the Offering Date of such subsequent Offering Period. 
 (b) Automatic Participation in
Pre-Registration Offering Period. Notwithstanding Section 7.1(a), each Employee who is an Eligible Employee as of the Offering Date of a Pre-Registration Offering Period shall automatically become a Participant in the Pre-Registration
Offering Period and shall be granted automatically a Purchase Right consisting of an option to purchase the lesser of (i) a number of whole shares of Stock determined in accordance with Section 8, or (ii) a number of whole shares of
Stock determined by dividing fifteen percent (15 %) of such Participant’s Compensation paid during the Pre-Registration Offering Period by the Purchase Price applicable to the Pre-Registration Offering Period. The Company shall not require or
permit any Participant to deliver a Subscription Agreement for participation in the Pre-Registration Offering Period prior to the Registration Date; provided, however, that following the applicable Registration Date a Participant may deliver a
Subscription Agreement to the office or representative designated by the Company if the Participant wishes to change the terms of the Participant’s participation in the Pre-Registration Offering Period. Such changes may include, for example, an
election to commence payroll deductions in accordance with Section 10. In addition, the Company may provide that following the Registration Date, if a Participant has not elected to confirm his or her enrollment in the Plan’s
Pre-Registration Offering Period, and to commence payroll deductions, then the Participant shall be automatically treated as withdrawing from the Pre-Registration Offering Period for all purposes of this Plan. 

7.2 Continued Participation. 

(a) Generally. Except as provided in Section 7.2(b), a Participant shall automatically participate in the next Offering Period
commencing immediately after the final Purchase Date of each Offering Period in which the Participant participates provided that the Participant remains an Eligible Employee on the Offering Date of the new Offering Period and has not either
(a) withdrawn from the Plan pursuant to Section 12.1, or (b) terminated employment or otherwise ceased to be an Eligible Employee as provided in Section 13. A Participant who may automatically participate in a subsequent Offering
Period, as provided in this Section, is not required to deliver any additional Subscription Agreement for the subsequent Offering Period in order to continue participation in the Plan. However, a Participant may deliver a new Subscription Agreement
for a subsequent Offering Period in accordance with the procedures set forth in Section 7.1(a) if the Participant desires to change any of the elections contained in the Participant’s then effective Subscription Agreement. 

(b) Participation Following Pre-Registration Offering Period. Notwithstanding Section 7.1(a), an Eligible Employee who was
automatically enrolled in a Pre-Registration Offering Period and who wishes to participate in an Offering Period which begins after the Pre-Registration Offering Period shall deliver a Subscription Agreement in accordance with Section 7.1(a) no
earlier than the applicable Registration Date and no later than the Subscription Date for such Offering Period, unless the Employee delivered a Subscription Agreement with respect to the Pre-Registration Offering Period as provided in
Section 7.1(b). 

  
 10 

	 	8.	RIGHT TO PURCHASE SHARES. 

8.1 Grant of Purchase Right. Except as provided in Section 7.1(b) with respect to a Pre-Registration Offering Period or as
otherwise provided below, on the Offering Date of each Offering Period, each Participant in such Offering Period shall be granted automatically a Purchase Right consisting of an option to purchase the lesser of (a) that number of whole shares
of Stock determined by dividing the Dollar Limit (determined as provided below) by the Fair Market Value of a share of Stock on such Offering Date or (b) the Share Limit (determined as provided below). The Committee may, in its discretion and
prior to the Offering Date of any Offering Period, (i) change the method of, or any of the foregoing factors in, determining the number of shares of Stock subject to Purchase Rights to be granted on such Offering Date, or (ii) specify a
maximum aggregate number of shares that may be purchased by all Participants in an Offering or on any Purchase Date within an Offering Period. No Purchase Right shall be granted on an Offering Date to any person who is not, on such Offering Date, an
Eligible Employee. For the purposes of this Section, the “Dollar Limit” shall be determined by multiplying $2,083.33 by the number of months (rounded to the nearest whole month) in the Offering Period and
rounding to the nearest whole dollar, and, for Offering Periods of six (6) months duration, the “Share Limit” shall be four hundred (400); provided, however, that if an Offering Period is established
for a period other than six (6) months, then the Share Limit shall be adjusted automatically on a pro rata basis (rounding to the nearest whole share), based on the number of months in such Offering Period (rounded to the nearest whole month).

 8.2 Calendar Year Purchase Limitation. Notwithstanding any provision of the Plan to the contrary, no Participant shall be granted
a Purchase Right which permits his or her right to purchase shares of Stock under the Plan to accrue at a rate which, when aggregated with such Participant’s rights to purchase shares under all other employee stock purchase plans of a
Participating Company intended to meet the requirements of Section 423 of the Code, exceeds Twenty-Five Thousand Dollars ($25,000) in Fair Market Value (or such other limit, if any, as may be imposed by the Code) for each calendar year in which
such Purchase Right is outstanding at any time. For purposes of the preceding sentence, the Fair Market Value of shares purchased during a given Offering Period shall be determined as of the Offering Date for such Offering Period. The limitation
described in this Section shall be applied in conformance with Section 423(b)(8) of the Code and the regulations thereunder. 
  

	 	9.	PURCHASE PRICE. 

 The Purchase Price
at which each share of Stock may be acquired in an Offering Period upon the exercise of all or any portion of a Purchase Right shall be established by the Committee; provided, however, that the Purchase Price on each Purchase Date shall not be less
than eighty-five percent (85%) of the lesser of (a) the Fair Market Value of a share of Stock on the Offering Date of the Offering Period or (b) the Fair Market Value of a share of Stock on the
Purchase Date. Until changed by the Committee, the amount determined pursuant to the preceding sentence shall be the Purchase Price. 

  
 11 

	 	10.	ACCUMULATION OF PURCHASE PRICE THROUGH PAYROLL DEDUCTION. 

Except as provided in Section 11.1(b) with respect to a Pre-Registration Offering Period and in Section 11.1(c) with respect to a
Non-United States Offering, shares of Stock acquired pursuant to the exercise of all or any portion of a Purchase Right may be paid for only by means of payroll deductions from the Participant’s Compensation accumulated during the Offering
Period for which such Purchase Right was granted, subject to the following: 
 10.1 Amount of Payroll Deductions. Except as otherwise
provided herein, the amount to be deducted under the Plan from a Participant’s Compensation on each pay day during an Offering Period shall be determined by the Participant’s Subscription Agreement. The Subscription Agreement shall set
forth the percentage of the Participant’s Compensation to be deducted on each pay day during an Offering Period in whole percentages of not less than one percent (1%) (except as a result of an election pursuant to Section 10.3 to stop
payroll deductions effective following the first pay day during an Offering) or more than fifteen percent (15%). 
 10.2
Commencement of Payroll Deductions. Payroll deductions shall commence on the first pay day following the Offering Date and shall continue to the end of the Offering Period unless sooner altered or terminated as provided herein; provided,
however, that with respect to a Pre-Registration Offering Period, payroll deductions shall commence as soon as practicable following the Company’s receipt of the Participant’s Subscription Agreement (delivered no earlier than the
applicable Registration Date), if any. 
 10.3 Election to Decrease or Stop Payroll Deductions. During an Offering Period, a
Participant may elect to decrease the rate of or to stop deductions from his or her Compensation by delivering to the Company office or representative designated by the Company (including a third-party administrator designated by the Company) an
amended Subscription Agreement authorizing such change on or before the “Change Notice Date.” The “Change Notice Date” shall be a date prior to the beginning of the first pay period for which such
election is to be effective as established by the Company from time to time and announced to the Participants. A Participant who elects, effective following the first pay day of an Offering Period, to decrease the rate of his or her payroll
deductions to zero percent (0%) shall nevertheless remain a Participant in such Offering Period unless the Participant withdraws from the Plan as provided in Section 12.1. 

10.4 Administrative Suspension of Payroll Deductions. The Company may, in its discretion, suspend a Participant’s payroll
deductions under the Plan as the Company deems advisable to avoid accumulating payroll deductions in excess of the amount that could reasonably be anticipated to purchase the maximum number of shares of Stock permitted (a) under the
Participant’s Purchase Right, or (b) during a calendar year under the limit set forth in Section 8.2. Unless the Participant has either withdrawn from the Plan as provided in Section 12.1 or has ceased to be an Eligible Employee,
suspended payroll deductions shall be resumed at the rate specified in the Participant’s then effective Subscription Agreement either (i) at the beginning of the next Offering Period if the reason for suspension was clause (a) in the
preceding sentence, or (ii) at the beginning of the next Offering Period having a first Purchase Date that falls within the subsequent calendar year if the reason for suspension was clause (b) in the preceding sentence. 

  
 12 

 10.5 Participant Accounts. Individual bookkeeping accounts shall be maintained for each
Participant. All payroll deductions from a Participant’s Compensation (and other amounts received from the Participant in a Pre-Registration Offering Period pursuant to Section 11.1(b) or a non-United States Participant pursuant to
Section 11.1(c)) shall be credited to such Participant’s Plan account and shall be deposited with the general funds of the Company. All such amounts received or held by the Company may be used by the Company for any corporate purpose. 

10.6 No Interest Paid. Interest shall not be paid on sums deducted from a Participant’s Compensation pursuant to the Plan or
otherwise credited to the Participant’s Plan account. 
  

	 	11.	PURCHASE OF SHARES. 

 11.1
Exercise of Purchase Right. 
 (a) Generally. Except as provided in Section 11.1(b) and Section 11.1(c), on
each Purchase Date of an Offering Period, each Participant who has not withdrawn from the Plan and whose participation in the Offering has not otherwise terminated before such Purchase Date shall automatically acquire pursuant to the exercise of the
Participant’s Purchase Right the number of whole shares of Stock determined by dividing (a) the total amount of the Participant’s payroll deductions accumulated in the Participant’s Plan account during the Offering Period and not
previously applied toward the purchase of Stock by (b) the Purchase Price. However, in no event shall the number of shares purchased by the Participant during an Offering Period exceed the number of shares subject to the Participant’s
Purchase Right. No shares of Stock shall be purchased on a Purchase Date on behalf of a Participant whose participation in the Offering or the Plan has terminated before such Purchase Date. 

(b) Purchase in Pre-Registration Period. Notwithstanding Section 11.1(a), on the Purchase Date of a Pre-Registration
Offering Period, each Participant who has not withdrawn from the Plan and whose participation in such Offering Period has not otherwise terminated before such Purchase Date shall automatically acquire pursuant to the exercise of the
Participant’s Purchase Right (i) a number of whole shares of Stock determined in accordance with Section 11.1(a) to the extent of the total amount of the Participant’s payroll deductions accumulated in the Participant’s Plan
account during the Pre-Registration Offering Period, if any, and not previously applied toward the purchase of Stock, and (ii) such additional shares of Stock (not exceeding in the aggregate the Participant’s Purchase Right) as determined
in accordance with a Cash Exercise Notice delivered to the Company office or representative designated by the Company (including a third-party administrator designated by the Company) no earlier than the applicable Registration Date and not later
than the close of business on the business day immediately preceding the Purchase Date or such earlier date as the Company shall establish, accompanied by payment of the Purchase Price for such additional shares in cash or by check. However, in no
event shall the aggregate number of shares purchased by a Participant during the Pre-Registration Offering Period exceed the number of shares subject to the Participant’s Purchase Right. In addition, if a Participant delivers a Subscription
Agreement to the Company after the applicable Registration Date, the Participant may not elect to exercise a 

  
 13 

 
Purchase Right pursuant to a Cash Exercise Notice in an amount which, when aggregated with payroll deductions pursuant to such Subscription Agreement, exceeds fifteen percent (15%) of the
Participant’s Compensation during the Pre-Registration Offering Period. The Company shall refund to the Participant in accordance with Section 11.4 any excess Purchase Price payment received from the Participant. 

(c) Purchase by Non-United States Participants for Whom Payroll Deductions Are Prohibited by Applicable Law. Notwithstanding
Section 11.1(a), where payroll deductions on behalf of Participants who are citizens or residents of countries other than the United States (without regard to whether they are also citizens of the United States or resident aliens) are
prohibited by applicable law, the Committee may establish a separate Offering (a “Non-United States Offering”) covering all Eligible Employees of one or more Participating Companies subject to such prohibition
on payroll deductions. The Non-United States Offering shall provide another method for payment of the Purchase Price with such terms and conditions as shall be administratively convenient and comply with applicable law. On each Purchase Date of the
Offering Period applicable to a Non-United States Offering, each Participant who has not withdrawn from the Plan and whose participation in such Offering Period has not otherwise terminated before such Purchase Date shall automatically acquire
pursuant to the exercise of the Participant’s Purchase Right a number of whole shares of Stock determined in accordance with Section 11.1(a) to the extent of the total amount of the Participant’s Plan account balance accumulated
during the Offering Period in accordance with the method established by the Committee and not previously applied toward the purchase of Stock. However, in no event shall the number of shares purchased by a Participant during such Offering Period
exceed the number of shares subject to the Participant’s Purchase Right. The Company shall refund to a Participant in a Non-United States Offering in accordance with Section 11.4 any excess Purchase Price payment received from such
Participant. 
 11.2 Pro Rata Allocation of Shares. If the number of shares of Stock which might be purchased by all Participants on
a Purchase Date exceeds the number of shares of Stock available in the Plan as provided in Section 4.1 or the maximum aggregate number of shares of Stock that may be purchased on such Purchase Date pursuant to a limit established by the
Committee pursuant to Section 8.1, the Company shall make a pro rata allocation of the shares available in as uniform a manner as practicable and as the Company determines to be equitable. Any fractional share resulting from such pro rata
allocation to any Participant shall be disregarded. 
 11.3 Delivery of Title to Shares. Subject to any governing rules or
regulations, as soon as practicable after each Purchase Date, the Company shall issue or cause to be issued to or for the benefit of each Participant the shares of Stock acquired by the Participant on such Purchase Date by means of one or more of
the following: (a) by delivering to the Participant evidence of book entry shares of Stock credited to the account of the Participant, (b) by depositing such shares of Stock for the benefit of the Participant with any broker with which the
Participant has an account relationship, or (c) by delivering such shares of Stock to the Participant in certificate form. 
 11.4
Return of Plan Account Balance. Any cash balance remaining in a Participant’s Plan account following any Purchase Date shall be refunded to the Participant as 

  
 14 

 
soon as practicable after such Purchase Date. However, if the cash balance to be returned to a Participant pursuant to the preceding sentence is less than the amount that would have been
necessary to purchase an additional whole share of Stock on such Purchase Date, the Company may retain the cash balance in the Participant’s Plan account to be applied toward the purchase of shares of Stock in the subsequent Purchase Period or
Offering Period. 
 11.5 Tax Withholding. At the time a Participant’s Purchase Right is exercised, in whole or in part, or at
the time a Participant disposes of some or all of the shares of Stock he or she acquires under the Plan, the Participant shall make adequate provision for the federal, state, local and foreign taxes (including social insurance), if any, required to
be withheld by any Participating Company upon exercise of the Purchase Right or upon such disposition of shares, respectively. A Participating Company may, but shall not be obligated to, withhold from the Participant’s compensation the amount
necessary to meet such withholding obligations. 
 11.6 Expiration of Purchase Right. Any portion of a Participant’s Purchase
Right remaining unexercised after the end of the Offering Period to which the Purchase Right relates shall expire immediately upon the end of the Offering Period. 

11.7 Provision of Reports and Stockholder Information to Participants. Each Participant who has exercised all or part of his or her
Purchase Right shall receive, as soon as practicable after the Purchase Date, a report of such Participant’s Plan account setting forth the total amount credited to his or her Plan account prior to such exercise, the number of shares of Stock
purchased, the Purchase Price for such shares, the date of purchase and the cash balance, if any, remaining immediately after such purchase that is to be refunded or retained in the Participant’s Plan account pursuant to Section 11.4. The
report required by this Section may be delivered in such form and by such means, including by electronic transmission, as the Company may determine. In addition, each Participant shall be provided information concerning the Company equivalent to
that information provided generally to the Company’s common stockholders. 
  

	 	12.	WITHDRAWAL FROM PLAN. 

12.1 Voluntary Withdrawal from the Plan. A Participant may withdraw from the Plan by signing and delivering to the Company office or
representative designated by the Company (including a third-party administrator designated by the Company) a written or electronic notice of withdrawal on a form provided by the Company for this purpose. Such withdrawal may be elected at any time
prior to the end of an Offering Period; provided, however, that if a Participant withdraws from the Plan after a Purchase Date, the withdrawal shall not affect shares of Stock acquired by the Participant on such Purchase Date. A Participant who
voluntarily withdraws from the Plan is prohibited from resuming participation in the Plan in the same Offering from which he or she withdrew, but may participate in any subsequent Offering by again satisfying the requirements of Sections 5 and
7.1. The Company may impose, from time to time, a requirement that the notice of withdrawal from the Plan be on file with the Company office or representative designated by the Company for a reasonable period prior to the effectiveness of the
Participant’s withdrawal. 

  
 15 

 12.2 Return of Plan Account Balance. Upon a Participant’s voluntary withdrawal from
the Plan pursuant to Section 12.1, the Participant’s accumulated Plan account balance which has not been applied toward the purchase of shares of Stock shall be refunded to the Participant as soon as practicable after the withdrawal,
without the payment of any interest, and the Participant’s interest in the Plan and the Offering shall terminate. Such amounts to be refunded in accordance with this Section may not be applied to any other Offering under the Plan. 

 

	 	13.	TERMINATION OF EMPLOYMENT OR ELIGIBILITY. 

Upon a Participant’s ceasing, prior to a Purchase Date, to be an Employee of the Participating Company Group for any reason, including
retirement, disability or death, or upon the failure of a Participant to remain an Eligible Employee, the Participant’s participation in the Plan shall terminate immediately. In such event, the Participant’s Plan account balance which has
not been applied toward the purchase of shares of Stock shall, as soon as practicable, be returned to the Participant or, in the case of the Participant’s death, to the Participant’s beneficiary designated in accordance with
Section 20, if any, or legal representative, and all of the Participant’s rights under the Plan shall terminate. Interest shall not be paid on sums returned pursuant to this Section 13. A Participant whose participation has been so
terminated may again become eligible to participate in the Plan by satisfying the requirements of Sections 5 and 7.1. 
  

	 	14.	EFFECT OF CHANGE IN CONTROL ON PURCHASE RIGHTS. 

In the event of a Change in Control, the surviving, continuing, successor, or purchasing corporation or parent thereof, as the case may be (the
“Acquiring Corporation”), may, without the consent of any Participant, assume or continue the Company’s rights and obligations under outstanding Purchase Rights or substitute substantially equivalent
purchase rights for the Acquiring Corporation’s stock. If the Acquiring Corporation elects not to assume, continue or substitute for the outstanding Purchase Rights, the Purchase Date of the then current Offering Period shall be accelerated to
a date before the date of the Change in Control specified by the Committee, but the number of shares of Stock subject to outstanding Purchase Rights shall not be adjusted. All Purchase Rights which are neither assumed or continued by the Acquiring
Corporation in connection with the Change in Control nor exercised as of the date of the Change in Control shall terminate and cease to be outstanding effective as of the date of the Change in Control. 

 

	 	15.	NONTRANSFERABILITY OF PURCHASE RIGHTS. 

Neither payroll deductions or other amounts credited to a Participant’s Plan account nor a Participant’s Purchase Right may be
assigned, transferred, pledged or otherwise disposed of in any manner other than as provided by the Plan or by will or the laws of descent and distribution. (A beneficiary designation pursuant to Section 20 shall not be treated as a disposition
for this purpose.) Any such attempted assignment, transfer, pledge or other disposition shall be without effect, except that the Company may treat such act as an election to withdraw from the Plan as provided in Section 12.1. A Purchase Right
shall be exercisable during the lifetime of the Participant only by the Participant. 

  
 16 

	 	16.	COMPLIANCE WITH SECURITIES LAW. 

The issuance of shares under the Plan shall be subject to compliance with all applicable requirements of federal, state and foreign law with
respect to such securities. A Purchase Right may not be exercised if the issuance of shares upon such exercise would constitute a violation of any applicable federal, state or foreign securities laws or other law or regulations or the requirements
of any securities exchange or market system upon which the Stock may then be listed. In addition, no Purchase Right may be exercised unless (a) a registration statement under the Securities Act shall at the time of exercise of the Purchase
Right be in effect with respect to the shares issuable upon exercise of the Purchase Right, or (b) in the opinion of legal counsel to the Company, the shares issuable upon exercise of the Purchase Right may be issued in accordance with the
terms of an applicable exemption from the registration requirements of the Securities Act. The inability of the Company to obtain from any regulatory body having jurisdiction the authority, if any, deemed by the Company’s legal counsel to be
necessary to the lawful issuance and sale of any shares under the Plan shall relieve the Company of any liability in respect of the failure to issue or sell such shares as to which such requisite authority shall not have been obtained. As a
condition to the exercise of a Purchase Right, the Company may require the Participant to satisfy any qualifications that may be necessary or appropriate, to evidence compliance with any applicable law or regulation, and to make any representation
or warranty with respect thereto as may be requested by the Company. 
  

	 	17.	RIGHTS AS A STOCKHOLDER AND EMPLOYEE. 

A Participant shall have no rights as a stockholder by virtue of the Participant’s participation in the Plan until the date of the
issuance of the shares of Stock purchased pursuant to the exercise of the Participant’s Purchase Right (as evidenced by the appropriate entry on the books of the Company or of a duly authorized transfer agent of the Company). No adjustment
shall be made for dividends, distributions or other rights for which the record date is prior to the date such shares are issued, except as provided in Section 4.3. Nothing herein shall confer upon a Participant any right to continue in the
employ of the Participating Company Group or interfere in any way with any right of the Participating Company Group to terminate the Participant’s employment at any time. 

 

	 	18.	NOTIFICATION OF DISPOSITION OF SHARES. 

The Company may require the Participant to give the Company prompt notice of any disposition of shares of Stock acquired by exercise of a
Purchase Right. The Company may require that until such time as a Participant disposes of shares of Stock acquired upon exercise of a Purchase Right, the Participant shall hold all such shares in the Participant’s name until the later of two
years after the date of grant of such Purchase Right or one year after the date of exercise of such Purchase Right. The Company may direct that the certificates evidencing shares of Stock acquired by exercise of a Purchase Right refer to such
requirement to give prompt notice of disposition. 

  
 17 

	 	19.	LEGENDS. 

 The Company may at any time place legends
or other identifying symbols referencing any applicable federal, state or foreign securities law restrictions or any provision convenient in the administration of the Plan on some or all of the certificates representing shares of Stock issued under
the Plan. The Participant shall, at the request of the Company, promptly present to the Company any and all certificates representing shares acquired pursuant to a Purchase Right in the possession of the Participant in order to carry out the
provisions of this Section. Unless otherwise specified by the Company, legends placed on such certificates may include but shall not be limited to the following: 

“THE SHARES EVIDENCED BY THIS CERTIFICATE WERE ISSUED BY THE CORPORATION TO THE REGISTERED HOLDER UPON THE PURCHASE OF SHARES UNDER AN EMPLOYEE STOCK
PURCHASE PLAN AS DEFINED IN SECTION 423 OF THE INTERNAL REVENUE CODE OF 1986, AS AMENDED. THE TRANSFER AGENT FOR THE SHARES EVIDENCED HEREBY SHALL NOTIFY THE CORPORATION IMMEDIATELY OF ANY TRANSFER OF THE SHARES BY THE REGISTERED HOLDER HEREOF.
THE REGISTERED HOLDER SHALL HOLD ALL SHARES PURCHASED UNDER THE PLAN IN THE REGISTERED HOLDER’S NAME (AND NOT IN THE NAME OF ANY NOMINEE).” 
  

	 	20.	DESIGNATION OF BENEFICIARY. 

20.1 Designation Procedure. Subject to local laws and procedures, a Participant may file a written designation of a beneficiary who is
to receive (a) shares and cash, if any, from the Participant’s Plan account if the Participant dies subsequent to a Purchase Date but prior to delivery to the Participant of such shares and cash, or (b) cash, if any, from the
Participant’s Plan account if the Participant dies prior to the exercise of the Participant’s Purchase Right. If a married Participant designates a beneficiary other than the Participant’s spouse, the effectiveness of such designation
may be subject to the consent of the Participant’s spouse. A Participant may change his or her beneficiary designation at any time by written notice to the Company. 

20.2 Absence of Beneficiary Designation. If a Participant dies without an effective designation pursuant to Section 20.1 of a
beneficiary who is living at the time of the Participant’s death, the Company shall deliver any shares or cash credited to the Participant’s Plan account to the Participant’s legal representative or as otherwise required by applicable
law. 
  

	 	21.	NOTICES. 

 All notices or other communications by a
Participant to the Company under or in connection with the Plan shall be deemed to have been duly given when received in the form specified by the Company at the location, or by the person, designated by the Company for the receipt thereof. 

  
 18 

	 	22.	AMENDMENT OR TERMINATION OF THE PLAN. 

The Committee may at any time amend, suspend or terminate the Plan, except that (a) no such amendment, suspension or termination shall
affect Purchase Rights previously granted under the Plan unless expressly provided by the Committee, and (b) no such amendment, suspension or termination may adversely affect a Purchase Right previously granted under the Plan without the
consent of the Participant, except to the extent permitted by the Plan or as may be necessary to qualify the Plan as an employee stock purchase plan pursuant to Section 423 of the Code or to comply with any applicable law, regulation or rule.
In addition, an amendment to the Plan must be approved by the stockholders of the Company within twelve (12) months of the adoption of such amendment if such amendment would authorize the sale of more shares than are then authorized for
issuance under the Plan or would change the definition of the corporations that may be designated by the Committee as Participating Companies. Notwithstanding the foregoing, in the event that the Committee determines that continuation of the Plan or
an Offering would result in unfavorable financial accounting consequences to the Company, the Committee may, in its discretion and without the consent of any Participant, including with respect to an Offering Period then in progress:
(i) terminate the Plan or any Offering Period, (ii) accelerate the Purchase Date of any Offering Period, (iii) reduce the discount or the method of determining the Purchase Price in any Offering Period (e.g., by determining the
Purchase Price solely on the basis of the Fair Market Value on the Purchase Date), (iv) reduce the maximum number of shares of Stock that may be purchased in any Offering Period, or (v) take any combination of the foregoing actions. 

IN WITNESS WHEREOF, the undersigned Assistant Secretary of the Company certifies that the foregoing sets forth the Neothetics, Inc. 2014
Employee Stock Purchase Plan as duly adopted by the Board on September 10, 2014 and ratified by the Board on November 4, 2014. 
  

	
	 /s/ Michael Kagnoff

	Michael Kagnoff, Assistant Secretary

  
 19 

 APPENDIX A 

Participating Companies 
 Neothetics, Inc. 

 TABLE OF CONTENTS 
  

											
	 	  	 	 	  	 	  	Page	 
			
	1.	  	  
	 Establishment, Purpose and Term of Plan
	  	 	1	  
				
		  	 	1.1	  	  	 Establishment
	  	 	1	  
		  	 	1.2	  	  	 Purpose
	  	 	1	  
		  	 	1.3	  	  	 Term of Plan
	  	 	1	  
			
	2.	  	  
	 Definitions and Construction
	  	 	1	  
				
		  	 	2.1	  	  	 Definitions
	  	 	1	  
		  	 	2.2	  	  	 Construction
	  	 	5	  
			
	3.	  	  
	 Administration
	  	 	6	  
				
		  	 	3.1	  	  	 Administration by the Committee
	  	 	6	  
		  	 	3.2	  	  	 Authority of Officers
	  	 	6	  
		  	 	3.3	  	  	 Power to Adopt Sub-Plans or Varying Terms with Respect to Non-U.S. Employees
	  	 	6	  
		  	 	3.4	  	  	 Power to Establish Separate Offerings with Varying Terms
	  	 	6	  
		  	 	3.5	  	  	 Policies and Procedures Established by the Company
	  	 	6	  
		  	 	3.6	  	  	 Indemnification
	  	 	7	  
			
	4.	  	  
	 Shares Subject to Plan
	  	 	7	  
				
		  	 	4.1	  	  	 Maximum Number of Shares Issuable
	  	 	7	  
		  	 	4.2	  	  	 Annual Increase in Maximum Number of Shares Issuable
	  	 	7	  
		  	 	4.3	  	  	 Adjustments for Changes in Capital Structure
	  	 	8	  
			
	5.	  	  
	 Eligibility
	  	 	8	  
				
		  	 	5.1	  	  	 Employees Eligible to Participate
	  	 	8	  
		  	 	5.2	  	  	 Exclusion of Certain Stockholders
	  	 	8	  
		  	 	5.3	  	  	 Determination by Company
	  	 	9	  
			
	6.	  	  
	 Offerings
	  	 	9	  
			
	7.	  	  
	 Participation in the Plan
	  	 	9	  
				
		  	 	7.1	  	  	 Initial Participation
	  	 	9	  
		  	 	7.2	  	  	 Continued Participation
	  	 	10	  
			
	8.	  	  
	 Right to Purchase Shares
	  	 	11	  
				
		  	 	8.1	  	  	 Grant of Purchase Right
	  	 	11	  
		  	 	8.2	  	  	 Calendar Year Purchase Limitation
	  	 	11	  
			
	9.	  	  
	 Purchase Price
	  	 	11	  
			
	10.	  	  
	 Accumulation of Purchase Price through Payroll Deduction
	  	 	12	  
				
		  	 	10.1	  	  	 Amount of Payroll Deductions
	  	 	12	  

  
 -i- 

 TABLE OF CONTENTS 

(continued) 
  

											
	 	  	 	 	  	 	  	Page	 
				
		  	 	10.2	  	  	 Commencement of Payroll Deductions
	  	 	12	  
		  	 	10.3	  	  	 Election to Decrease or Stop Payroll Deductions
	  	 	12	  
		  	 	10.4	  	  	 Administrative Suspension of Payroll Deductions
	  	 	12	  
		  	 	10.5	  	  	 Participant Accounts
	  	 	13	  
		  	 	10.6	  	  	 No Interest Paid
	  	 	13	  
			
	11.	  	  
	 Purchase of Shares
	  	 	13	  
				
		  	 	11.1	  	  	 Exercise of Purchase Right
	  	 	13	  
		  	 	11.2	  	  	 Pro Rata Allocation of Shares
	  	 	14	  
		  	 	11.3	  	  	 Delivery of Title to Shares
	  	 	14	  
		  	 	11.4	  	  	 Return of Plan Account Balance
	  	 	14	  
		  	 	11.5	  	  	 Tax Withholding
	  	 	15	  
		  	 	11.6	  	  	 Expiration of Purchase Right
	  	 	15	  
		  	 	11.7	  	  	 Provision of Reports and Stockholder Information to Participants
	  	 	15	  
			
	12.	  	  
	 Withdrawal from Plan
	  	 	15	  
				
		  	 	12.1	  	  	 Voluntary Withdrawal from the Plan
	  	 	15	  
		  	 	12.2	  	  	 Return of Plan Account Balance
	  	 	16	  
			
	13.	  	  
	 Termination of Employment or Eligibility
	  	 	16	  
			
	14.	  	  
	 Effect of Change in Control on Purchase Rights
	  	 	16	  
			
	15.	  	  
	 Nontransferability of Purchase Rights
	  	 	16	  
			
	16.	  	  
	 Compliance with Securities Law
	  	 	17	  
			
	17.	  	  
	 Rights as a Stockholder and Employee
	  	 	17	  
			
	18.	  	  
	 Notification of Disposition of Shares
	  	 	17	  
			
	19.	  	  
	 Legends
	  	 	18	  
			
	20.	  	  
	 Designation of Beneficiary
	  	 	18	  
				
		  	 	20.1	  	  	 Designation Procedure
	  	 	18	  
		  	 	20.2	  	  	 Absence of Beneficiary Designation
	  	 	18	  
			
	21.	  	  
	 Notices
	  	 	18	  
			
	22.	  	  
	 Amendment or Termination of the Plan
	  	 	19	  

  
 -ii-

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00237-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00237-of-00352.parquet"}], [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00237-of-00352.parquet"}], [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00237-of-00352.parquet"}]]