Document:

Amended and Restated Registration Rights Agreement - March 9, 2005

 Exhibit 10.42 
  
 AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT 
  
 THIS AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT (this “Agreement”) is made as of March 9, 2005, by
and among Boston Life Sciences, Inc., a Delaware corporation (the “Company”), the parties listed on Schedule 1 hereof (the “Initial Holders”) and such additional parties as may be added thereto from time to time
upon execution of a joinder agreement in a form satisfactory to the Company (each such party a “Subsequent Holder”, and together with the Initial Holders, the “Holders”): 
  
 W I T N E S S E
T H: 
  
 WHEREAS, the Company and certain of the
Initial Holders entered into that certain Registration Rights Agreement, dated as of July 25, 2002 (the “Prior Registration Rights Agreement”); 
  

WHEREAS, the Company issued a warrant to Ingalls & Snyder Value Partners, L.P. (“ISVP”) to purchase 500,000 shares of the
Company’s Common Stock (the “ISVP Warrant”) pursuant to that certain Securities Purchase Agreement dated as of July 25, 2002, by and among the Company and the purchasers set forth therein, which ISVP Warrant was amended on
November 12, 2004; 
  
 WHEREAS, the Company issued a warrant to
Robert L. Gipson (“Gipson”) to purchase 1,000,000 shares of the Company’s Common Stock (the “Gipson Warrant”) and issued a warrant to Nikolaos D. Monoyios (“Monoyios”) to purchase 820,123
shares of the Company’s Common Stock (the “Monoyios Warrant”, together with the ISVP Warrant and the Gipson Warrant, the “Warrants”) pursuant to that certain Consent to Transfer and Warrant Amendment, dated as
of November 22, 2002, by and among the Company, Ingalls & Snyder, L.L.C., Gipson, Monoyios and ISVP; 
  
 WHEREAS, on February 4, 2005 the Company effected a 1-for-five reverse stock split; 
  
 WHEREAS, in consideration of the immediate exercise of the Warrants in cash, the Warrants were each amended on February 11,
2005 to reduce the exercise price of each of the Warrants; 
  
 WHEREAS, certain of the Initial Holders are purchasing up to $5,000,000 in Shares (as defined below) pursuant to the terms and conditions of a certain Common Stock Purchase Agreement of even date herewith (the “Purchase
Agreement”) and in connection therewith are entitled to receive registration rights with respect to the Shares and Warrant Shares (as defined below) on the terms set forth in this Agreement; 
  
 WHEREAS, in connection with the execution of the Purchase Agreement, the
Company and ISVP desire to amend and restate the Prior Registration Rights Agreement to provide for certain rights with respect to the registration of shares of capital stock of the Company under the Securities Act (as defined below); 

 WHEREAS, pursuant to Section 12(a) of the Prior Registration Rights Agreement, such agreement could be
amended, modified or supplemented or any provision therein waived upon the approval of Holders (as defined therein) holding at least 67% of the Registrable Shares (as defined therein) then held by the Holders (the “Requisite
Approval”); and 
  
 WHEREAS, upon execution of this
Agreement by ISVP, the Requisite Approval shall have been received by the Company, and pursuant to Section 12 of the Prior Registration Rights Agreement and Section 12(h) of this Agreement, this Agreement shall be binding upon each of the parties to
the Prior Registration Rights Agreement. 
  
 NOW, THEREFORE, in
consideration of the premises and the mutual covenants and agreements set forth herein and other good and valuable consideration the mutual receipt and sufficiency of which is hereby acknowledged, the parties agree as follows: 
  
 1. Defined Terms. As used in this Agreement the following terms have
the following meanings. 
  
 “Affiliate” means, as to any specified Person, any other Person that, directly or indirectly through one or more intermediaries or otherwise, controls, is controlled by or is under common control with the specified Person.
This definition uses “control” to mean the possession, directly or indirectly, of the power to direct or cause the direction of the management or policies of a Person (whether through ownership of capital stock of that Person, by contract
or otherwise). 
  
 “Blue Sky
Laws” has the meaning Section 5(f) specifies. 
  
 “Board of Directors” means the Board of Directors of the Company. 
  
 “Business Day” means any day, excluding Saturday, Sunday and federally recognized holidays. 
  
 “Claims” has the meaning Section 11(a)
specifies. 
  
 “Closing Date”
means the date of the closing of the transactions contemplated by the Purchase Agreement. 
  
 “Common Stock” means the common stock, par value $.01 per share, of the Company. 
  
 “Eligible Offering” has the meaning Section
4(a) specifies. 
  
 “Exchange
Act” means the Securities Exchange Act of 1934, as amended, and any successor thereto and the rules and regulations thereunder. 
  
 “Exempt Offering” means any offering by the Company of shares of Common Stock (i) in connection with or pursuant to any
benefit, compensation, incentive or savings plan or program in which any of the officers, directors, employees or independent contractors of the Company or any of its subsidiaries participate, (ii) as consideration in 

  

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any business combination or other acquisition transaction, (iii) as the securities into or for which other equity or debt securities are convertible or
exchangeable, or as the securities that may be acquired by the exercise of options, warrants or other rights or (iv) made only to existing holders of securities issued by the Company. 
  
 “Holder” means at any time any Person then owning Registrable Shares and having the rights
and obligations of a Holder and which (i) is an Initial Holder, (ii) has been assigned those rights and obligations pursuant to Section 10(a) or (iii) has become a Subsequent Holder pursuant to Section 10(b) and upon execution of a joinder agreement
satisfactory to the Company. 
  
 “Indemnified Party” has the meaning Section 11(b) specifies. 
  
 “Initial Holders” has the meaning the preamble hereto specifies. 
  
 “Inspector” has the meaning Section 5(e)
specifies. 
  
 “ISVP” has the
meaning the preamble hereto specifies. 
  
 “Lockup Period” has the meaning Section 8 specifies. 
  
 “Person” means any natural person, sole proprietorship, corporation, partnership, limited liability company, business
trust, unincorporated organization or association, estate or trust or other entity. 
  
 “Preliminary Prospectus” means, as applied to any registration statement the Company files under the Securities Act to
register shares of Common Stock for its public offering of those shares (other than in an Exempt Offering), the prospectus that registration statement includes which is labeled “subject to completion” and is first used in
“roadshow” presentations by the Company to potential investors in connection with that offering. 
  
 “Prior Registration Rights Agreement” has the meaning the preamble hereto specifies. 
  
 “Proceeding” has the meaning Section 11(b)
specifies. 
  
 “Records” has the
meaning Section 5(e) specifies. 
  
 “Registrable Shares” means (i) all Shares, (ii) all Warrant Shares acquired upon exercise of the Warrants, (iii) any securities of the Company designated as Registrable Securities pursuant to Section 10(b) (the
“Additional Securities”) and any securities of the Company issued or issuable with respect to the Shares, Warrant Shares or the Additional Securities by way of conversion, exchange, dividend or stock split or combination. For
purposes of this Agreement, a share of Registrable Shares will cease to be Registrable Shares when (a) a registration statement covering that Registrable Share has been filed and become effective under the Securities Act and its Holder distributes
it by means of that effective registration statement or (b) its Holder distributes such Registrable Share pursuant to Rule 144 or (c) such securities become freely saleable under Rule 144(k). 
  

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 “Registration” has the meaning Section 3(a) specifies. 
  
 “Registration Notice” has the meaning
Section 4(b) specifies. 
  
 “Related
Party” means, as to any specified Person, any other Person who is an officer, director or agent of the specified Person or who controls the specified Person within the meaning of Section 15 of the Securities Act or Section 20 of the
Exchange Act. 
  
 “Reporting
Date” has the meaning Section 6 specifies. 
  
 “Requesting Holder” has the meaning Section 4(d) specifies. 
  
 “Request Notice” has the meaning Section 4(c) specifies. 
  
 “Rule 144” means Rule 144 (or any similar or successor provision) under the Securities Act.

  
 “SEC” means the Securities
and Exchange Commission and any successor thereto as the agency administering the Securities Act. 
  
 “Securities Act” means the Securities Act of 1933, as amended, and any successor thereto and the rules and regulations
thereunder. 
  
 “Sellers’
Registration Statement” means a registration statement filed by the Company under the Securities Act to register Registrable Shares for resale by Holders pursuant to the registration rights provided for under Section 3 or 4. 
  
 “Selling Holder” has the meaning Section
5(c) specifies. 
  
 “Shares” has
the meaning ascribed to it in the Purchase Agreement. 
  
 “Purchase Agreement” has the meaning the preamble hereto specifies. 
  
 “Warrants” has the meaning the preamble hereto specifies. 
  
 “Warrant Shares” means the shares of Common Stock issued upon exercise of the Warrants.

  
 2. Other Definitional Provisions. 
  
 (a) This Agreement uses the words “herein,” “hereof,”
“hereto” and “hereunder” and words of similar import to refer to this Agreement as a whole and not to any provision of this Agreement. 
  

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 (b) Whenever the context so requires, the singular number includes the plural and vice versa, and a
reference to one gender includes the other genders. 
  
 (c) The
word “including” (and, with correlative meaning, the word “include”) means including without limiting the generality of any description preceding that word, and the verbs “shall” and “will” are used
interchangeably and have the same meaning. 
  
 (d) The term
“underwriter,” as used herein, does not include any Holder. 
  
 (e) Terms that are capitalized in this Agreement but not otherwise defined, shall have the meanings ascribed to them in the Purchase Agreement. 
  
 3. Demand Registration Rights. 
  
 (a) Upon written notice to the Company, Holders of at least a majority of the then outstanding Registrable Shares, specifying the estimated number of
Registrable Shares intended to be registered, may request that the Company effect the registration under the Securities Act of all or a specified part of the Registrable Shares held by such Holders (a “Registration”), provided such
Registrable Shares have an aggregate value of at least $500,000 (based on the public market price on the date of such request). The Company will then use its commercially reasonable efforts to file and maintain the Registration under the Securities
Act of the Registrable Shares together with all other Registrable Shares which the Company has been requested to register by written notice delivered pursuant to Section 4(c) after the Company has given the written notice required by Section 4(b),
all to the extent required to permit the disposition (in accordance with the intended methods thereof) of the Registrable Shares which the Company has been so requested to register; provided, however, that the Company shall not be
obligated to take any action to effect any such Registration and shall not be obligated to effect such Registration pursuant to this Section 3(a): 
  
 (i) Within 180 days immediately following the effective date of any registration statement pertaining to a public offering of securities of the Company
for its own account (other than an Exempt Offering); or 
  
 (ii)
If the Company shall have furnished to such Holders which the Company has been requested to register pursuant to this Section 3(a) a certificate, signed by the President or Chief Executive Officer of the Company, stating that the Board of Directors
has determined in its good faith judgment that such Registration would be expected to have (i) a material adverse effect on (or require premature disclosure of) any proposal or plan by the Company to engage in any material acquisition of assets
(other than in the ordinary course) or stock or any material merger, consolidation, tender offer, reorganization or similar transaction, or (ii) a material adverse effect on a registration of securities of the Company which is proposed to be filed
within 90 days of such request, in which case the Company shall have an additional period of not more than 90 days within which to file such Sellers’ Registration Statement; provided, however, that the Company shall not so
postpone a registration pursuant to this clause (ii) more than once in any twelve month period. 
  

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 4. Piggyback Registration Rights. 
  
 (a) If at any time or from time to time the Company proposes to register any shares of Common Stock under the Securities Act
for its own account other than pursuant to an Exempt Offering, in the United States of those shares for cash, including without limitation, a Registration pursuant to Section 3 (each such public offering, other than an Exempt Offering, being an
“Eligible Offering”), then, at each of those times, each then Holder will, subject to the terms and conditions hereof, be entitled to have such number of that Holder’s Registrable Shares as that Holder may request in accordance
with Section 4(c) registered under the Securities Act for disposition by means of the registration statement relating to that Eligible Offering. 
  
 (b) In the case of each Eligible Offering, the Company will deliver to each then Holder a written notice of that offering (a “Registration
Notice”) at least ten days prior to its filing with the SEC of the registration statement, or the amendment thereto, which includes the Preliminary Prospectus for that offering. The Company will briefly describe in each Registration Notice
the Eligible Offering to which that notice relates and inform the addressee that it has five days within which to request to include any or all of its Registrable Shares in the registration statement for that offering. 
  
 (c) Any Holder desiring to participate in any Eligible Offering must deliver
to the Company within five days after the Holder receives the Registration Notice for that offering a written notice to that effect (a “Request Notice”) which specifies the number of the Holder’s Registrable Shares the Holder
desires to have registered under the Securities Act for inclusion in that offering. Any Holder that does not deliver a Request Notice for an Eligible Offering within that five-day period will be deemed to have waived its right to participate in that
offering unless the Company agrees otherwise in writing. 
  
 (d)
Any holder that delivers a Request Notice relating to an Eligible Offering on a timely basis, or as otherwise agreed by the Company, pursuant to Section 4(c) (each such Holder being a “Requesting Holder”) will be entitled to offer
and sell up to the number of its Registrable Shares specified in its Request Notice in that offering on the terms and conditions on which the Company offers and sells shares of Common Stock in that offering if the Requesting Holder complies with the
applicable provisions of Sections 5, 6 and 11; provided, however, that: (i) the Company may reserve to itself the right to be the exclusive grantor of any underwriter’s over allotment option; and (ii) the number of Registrable Shares any
Requesting Holder will be entitled to offer and sell will be subject to reduction as set forth in Section 4(e) below. 
  
 (e) The Company will have the right to determine the aggregate size of each Eligible Offering and to limit the number of Registrable Shares to be included
in each such offering without reducing the number of shares, if any, of Common Stock to be offered by the Company in that offering, as follows: (i) if the lead managing underwriter selected by the Company for an Eligible Offering (or, if that
offering will not be underwritten, a qualified independent underwriter (as defined in Rule 2720 of the NASD Conduct Rules) serving as financial advisor to the Company) determines that marketing factors render necessary or advisable a limitation on
the number of Registrable Shares to be included in that offering, the Company will be required to include in that offering only such number of Registrable Shares, if any, as that lead managing underwriter (or financial advisor, as the case may be)
believes will not jeopardize the success of the primary offering by the Company; and (ii) if the Company limits the number of Registrable Shares that Requesting Holders may include in any Eligible Offering pursuant to clause (i), but 

  

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does not exclude all such Registrable Shares from that offering, the maximum number of Registrable Shares to be included in that offering on behalf of each
of those Requesting Holders will be the product of (A) the number of Registrable Shares that the Company has allocated to the Requesting Holders in the offering multiplied by (B) a fraction, the numerator of which is the number of Registrable Shares
that each such Requesting Holder has specified in its Request Notice relating to that offering and the denominator of which is the aggregate number of Registrable Shares all Requesting Holders have specified in their Request Notices relating to that
offering. 
  
 (f) In connection with each Eligible Offering, the
Company, in its sole discretion, will determine whether to proceed with or terminate or postpone that offering and to select any underwriter or underwriters to administer that offering. 
  
 5. Registration Procedures. 
  

Whenever the Company must register Registrable Shares pursuant to a Registration in accordance with Section 3 or include Registrable Shares in a
registration statement relating to an Eligible Offering in accordance with Section 4, it will, subject to the applicable terms and conditions hereof: 
  
 (a) cause those shares to be registered under the Securities Act by means of a Sellers’ Registration Statement as soon as practicable, in either the
original filing thereof or in a pre-effective amendment to a previously filed registration statement; 
  
 (b) prior to the first to occur of (i) the sale by the Holders thereof, by means of the Sellers’ Registration Statement after it becomes effective
under the Securities Act, of all the Registrable Shares covered by the Sellers’ Registration Statement when it becomes effective under the Securities Act and the elapse of the period in which a dealer is required by the Securities Act to
deliver a prospectus in connection with its offer and sale of any of those shares and (ii) the withdrawal by the Company of the Sellers’ Registration Statement pursuant to Securities Act Rule 477, prepare and file with the SEC under the
Securities Act such amendments (including post-effective amendments) to the Sellers’ Registration Statement and Supplements to the related prospectus as are necessary (A) to reflect the plan of distribution contemplated by the Sellers’
Registration Statement and (B) so that (1) neither the Sellers’ Registration Statement nor that prospectus contains any untrue statement of a material fact or omits to state a material fact required to be stated therein or necessary to make the
statements therein not misleading and (2) both the Sellers’ Registration Statement and that prospectus comply in all material respects with all other applicable legal requirements; 
  
 (c) provide to each Holder named as a selling stockholder in the Sellers’ Registration Statement in accordance with
such Holder’s exercise of its registration rights under this Agreement (each a “Selling Holder”) such number of prospectuses (including preliminary prospectuses) and other documents incident to the offering and sale of that
Selling Holder’s Registrable Shares by means of the Sellers’ Registration Statement as that Selling Holder may from time to time reasonably request; 
  

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 (d) prior to the time the Sellers’ Registration Statement or any post-effective amendment thereto
becomes effective under the Securities Act, provide an opportunity to review and comment with respect to that document to one counsel selected by Selling Holders holding a majority of the Registrable Shares covered by that document and reasonably
satisfactory to the Company; 
  
 (e) provide to each Selling
Holder, any managing underwriter participating in the distribution of the Registrable Shares covered by the Sellers’ Registration Statement and any accountant, lawyer or other professional retained by that Selling Holder or managing underwriter
(each an “Inspector”) reasonable access to appropriate officers and employees of the Company to ask questions and obtain information reasonably requested by that Inspector in connection with that Sellers’ Registration
Statement; provided, however, that in connection with any such access or request, each Selling Holder will and will cause each of its representative Inspectors to, and the Company may require each other Inspector to, (i) cooperate to the
extent reasonably practicable to minimize any disruption in the operation by the Company of its business, (ii) keep confidential all records, documents and information the Company advises are confidential or of a proprietary nature (collectively,
the “Records”) and (iii) not use the information it obtains from the Records as a basis for any market transactions in the securities of the Company unless and until that information is in the public domain or otherwise becomes
publicly available; 
  
 (f) use its good-faith efforts to register
and qualify the Registrable Shares covered by the Sellers’ Registration Statement under the applicable securities or “blue sky” laws (collectively, “Blue Sky Laws”) of such jurisdictions as any Selling Holder may
reasonably request, provided that it will not be required to (i) qualify generally to do business in any jurisdiction where it otherwise would not be required to qualify but for this Section 5(f), (ii) subject itself to taxation in any such
jurisdiction or (iii) consent to general service of process in any such jurisdiction; 
  
 (g) notify each Selling Holder promptly (i) when it is informed that the Sellers’ Registration Statement or any post-effective amendment thereto becomes effective under the Securities Act, (ii) of any request by
the SEC for an amendment to the Sellers’ Registration Statement or a supplement to any related prospectus, (iii) of the issuance by the SEC of any stop order suspending the effectiveness of the Sellers’ Registration Statement or any order
preventing or suspending the use of any related prospectus or the initiation or threat by the SEC of any proceeding for any of those purposes, (iv) of the suspension of the qualification of any Registrable Shares covered by the Sellers’
Registration Statement for sale in any jurisdiction or the initiation or threat of any proceeding for that purpose and (v) of any determination by it that any event has occurred or fact exists which makes untrue any statement of a material fact
included in the Sellers’ Registration Statement or any related then current prospectus or which requires the making of a change in the Sellers’ Registration Statement or that prospectus in order that the same will not contain any untrue
statement of a material fact or omit to state a material fact required to be contained therein or necessary to make the statements therein not misleading; 
  
 (h) if any order is issued which (i) suspends the effectiveness of the Sellers’ Registration Statement, (ii) suspends or prevents the use of any
related then current prospectus or (iii) suspends the qualification of any Registrable Shares covered by the Sellers’ Registration Statement for sale in any jurisdiction, use commercially reasonable efforts to obtain the withdrawal of that
order; 
  

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 (i) if the Eligible Offering to which the Sellers’ Registration Statement relates is being
underwritten by underwriters, (i) enter into agreements customary at the time (including an underwriting or purchase agreement in then-customary form) as those underwriters reasonably may request in order to facilitate the disposition of the
Registrable Shares in that offering, (ii) use reasonable diligence to obtain an opinion of legal counsel (who may be its general counsel) covering such matters as are then customarily covered by opinions addressed to those underwriters by an
issuer’s counsel and (iii) use reasonable diligence to obtain a “comfort” letter or letters from its independent public accountants in their customary form and covering such matters of the type then customarily covered by
“comfort” letters as those underwriters reasonably may request; and 
  
 (j) otherwise use its good-faith efforts to comply with all applicable rules and regulations of the SEC and make available to its security holders, as soon as reasonably practicable, an earnings statement that (i)
covers a period of at least 12 months beginning within three months after the effective date of the Sellers’ Registration Statement and (ii) satisfies the provisions of Section 11(a) of the Securities Act. 
  
 (k) if at any time after a Sellers’ Registration Statement has become
effective the Company is engaged in any activity the public disclosure of which the Company determines, in its reasonable business judgment, would be detrimental to the Company, then the Company may direct that use of the prospectus contained in the
Sellers’ Registration Statement be suspended. The Company will notify all selling Holders of the suspension, and each selling Holder will immediately discontinue any sales of Registrable Shares pursuant to such registration statement until such
selling Holder has received copies of a supplemented or amended prospectus or until such selling Holder is advised in writing by the Company that the then-current prospectus may be used and has received copies of any additional or supplemental
filings that are incorporated or deemed incorporated by reference in such prospectus. The Company will use its commercially reasonable efforts to terminate any such suspension and reinstate the ability of all selling Holders to use the prospectus
contained in the Sellers’ Registration Statement, as amended or Supplemented, as the case may be, as soon as is practicable. The Company may not exercise the rights provided by this Section 5(k) to effect a suspension for more than 60 days (90
days if such event causing the suspension relates to a potential acquisition or merger) in the aggregate during any twelve-month period. 
  
 6. Underwriting Arrangements. No Holder will be permitted to participate in any registration hereunder of securities being underwritten and offered
for resale by underwriters unless the Holder (i) agrees to sell the Holder’s Registrable Shares on the basis provided in any underwriting arrangements approved by the Persons entitled hereunder to approve those arrangements, (ii) enters into a
written agreement with the managing underwriter or the representative of the underwriters in such form and containing such provisions as are then customary in the securities business for such an arrangement between those underwriters and issuers of
the Company’s size and investment stature and (iii) completes and executes all questionnaires, powers of attorney, indemnities and other documents, and obtains such spousal or other consents, as are reasonably required under the terms of those
arrangements and this 

  

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Agreement. If a Selling Holder disapproves of the proposed terms of any such underwriting, it may elect to withdraw therefrom by written notice to the
Company and the managing underwriter, delivered not less than ten days before the Sellers’ Registration Statement is declared effective under the Securities Act (the “Reporting Date”). 
  
 7. Rule 144 Reporting. The Company will: 
  
 (a) make and keep public information available (as those terms are
understood and defined in Rule 144) at all times from and after 90 days following the Reporting Date; 
  
 (b) use its good-faith efforts to file with the SEC in a timely manner all reports and other documents Section 13 or 15(d) of the Exchange Act, as
applicable, requires it to file with the SEC; and 
  
 (c) so long
as a Holder owns Registrable Shares, deliver to the Holder, on the Holder’s request, a written statement as to whether it is in compliance with the requirements referred to in clauses (i) and (ii) above (if it is then subject to those
requirements). 
  
 8. Market Standoff. Each Holder agrees,
to the extent permitted by applicable law, that, for so long as the Holder holds Registrable Shares, the Holder will not, except as Sections 3 and 4 permit, sell, transfer or otherwise dispose of in a public transaction (including through put or
short-sale arrangements) shares of Common Stock in the period (i) beginning ten days prior to the effectiveness under the Securities Act of any registration statement covering shares of Common Stock being publicly offered in an Eligible Offering or
in an Exempt Offering of the type specified in clause (iii) of the definition of Exempt Offering and (ii) ending 90 days (or such greater period as may be requested by the underwriter in any such Eligible Offering or Exempt Offering following the
date of that effectiveness (each such period being a “Lockup Period”). The Company will provide each Holder written notice of any Lockup Period. 
  
 9. Registration Expenses. 
  

(a) Except as Section 9(b) provides, the Company will pay or otherwise bear all the expenses attributable to the registration of Registrable Shares
under the Securities Act for sale pursuant to Section 3 or 4, including all the following: (i) registration and filing fees payable under the Securities Act or Blue Sky Laws; (ii) fees and expenses incurred in complying with Blue Sky Laws, including
the reasonable fees and disbursements of counsel incurred in that connection; (iii) printing expenses; (iv) messenger and delivery expenses; (v) the Company’s internal expenses, including the salaries and expenses of its employees; (vi) fees
and expenses attributable to the listing of the Registrable Shares on each securities exchange (including, for this purpose, the Nasdaq SmallCap Market) on which the Common Stock is then listed or included at the Company’s initiation; (vii)
registrar and transfer agents’ fees; (viii) fees and disbursements of the Company’s counsel and independent certified public accountants; (ix) Securities Act liability insurance premiums (if the Company elects to obtain that insurance);
and (x) fees and expenses of any special experts or other Persons the Company retains in connection with its compliance with this Agreement. 
  
 (b) Each Selling Holder will pay or otherwise bear all underwriting commissions and discounts and transfer taxes attributable to that Selling
Holder’s sale or other disposition of 

  

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Registrable Shares, and each Holder will pay or otherwise bear (i) the fees and expenses of that Holder’s counsel and any other special experts or
Persons that Holder retains in connection with any Seller’s Registration Statement or the sale or other disposition of that Holder’s Registrable Shares and (ii) that Holder’s internal expenses, including the salaries and expenses of
that Holder’s employees. 
  
 10. Transfers and Additional
Grants of Registration Rights. 
  
 (a) A Holder may not
transfer the registration rights this Agreement affords the Holder to any other Person except as follows: (i) a Holder who is a natural person may transfer those rights to a member of his immediate family (including his parents) or a trust for the
benefit of one or more members of his immediate family; (ii) a Holder that is a corporation may transfer its rights to its sole shareholder; (iii) a Holder that is a partnership or limited liability company may transfer those rights to its partners
or members, as the case may be; (iv) a Holder may transfer those rights to any other Holder and (v) a Holder may transfer those rights in conjunction with a transfer of the Purchase Agreement or the Warrants in accordance with the terms of the
Purchase Agreement; provided, that any such transfer will be permitted only if (A) such rights are transferred to the transferee thereof together with a permitted transfer of the Warrants or Warrant Shares and (B) the transferee executes a joinder
to this Agreement, in a form satisfactory to the Company, in which that transferee agrees to comply with and otherwise be bound by all the terms and conditions hereof. 
  
 (b) The Company may, without the consent of any Holder, extend the registration rights this Agreement provides to the
Persons who become holders of Common Stock as a result of distributions thereof made by a Holder that is a partnership to its partners, or by a Holder that is a limited liability company to its members or by a Holder that is a corporation to its
sole shareholder, and the Company may, without the consent of any Holder, extend the registration rights this Agreement provides to additional Persons who become holders of equity securities of the Company after the date hereof, in each case by
entering into one more joinders to this Agreement with those Persons pursuant to which, for all purposes hereof, those Persons will become Holders. Nothing herein will limit or otherwise restrict the ability or right of the Company to grant to any
Person any registration or similar rights in the future respecting Additional Securities the Company may issue, whether pursuant to the provisions of this Section 10 or otherwise. 
  
 11. Indemnification: Contribution. 
  
 (a) Indemnification by the Company. The Company will, to the extent applicable law permits, indemnify each Selling
Holder who sells Registrable Shares by means of a Sellers’ Registration Statement and each of that Selling Holder’s Related Parties against, and hold each of those Persons harmless from and in respect of, any and all claims, damages,
losses, liabilities and expenses (including reasonable legal expenses) whatsoever (collectively, “Claims”) that arise from or are based on any untrue statement or alleged untrue statement of a material fact contained in that
Sellers’ Registration Statement or any prospectus (including any preliminary prospectus) forming a part thereof, or any amendment thereof or supplement thereto, or any omission or alleged omission to state therein a material fact required to be
stated therein or necessary to make the statements therein not misleading in the light of the circumstances under 

  

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which they were made, except insofar as those Claims arise out of or are based on any such untrue statement or omission or allegation thereof based on
information furnished in writing to the Company by or on behalf of that Selling Holder expressly for use therein. In connection with any underwritten offering of shares of Registrable Shares, the Company will indemnify and hold harmless each
participating underwriter and each of that underwriter’s Related Parties on either (i) substantially the same basis on which it will indemnify each Selling Holder and that Selling Holder’s Related Parties pursuant to this Section 11(a) or
(ii) such other basis as underwriters customarily obtain from issuers at the time of that offering. Notwithstanding the foregoing, the Company’s obligations to indemnify and hold harmless pursuant to this Section 11(a) with respect to any Claim
(or action or proceeding in respect thereof) that arises from or is based on any untrue or alleged untrue statement contained in, or any omission or alleged omission from, any preliminary prospectus will not inure to the benefit of any Selling
Holder or underwriter or its Related Parties if it is determined that (i) a copy of the prospectus used to confirm the sale of Registrable Shares to the Person asserting that claim was not sent or given to that Person at or prior to the written
confirmation of that sale, (ii) the untrue statement or alleged untrue statement or the omission or alleged omission was corrected by that prospectus and (iii) it was the responsibility of that Selling Holder or that underwriter (or any dealer
acquiring those shares directly or indirectly from that underwriter) to send or give that prospectus to that Person. 
  
 (b) Conduct of Indemnification Proceedings. Each Person claiming indemnification from the Company pursuant to this Section 11 (an
“Indemnified Party”) will, promptly after that Indemnified Party becomes aware of any assertion or commencement of any action or proceeding against that Indemnified Party in respect of which indemnity may be sought from the Company
(a “Proceeding”), promptly notify the Company in writing of the Proceeding, provided, that an Indemnified Party’s failure to so notify the Company will not relieve the Company from any liability it may have to that Indemnified
Party other than pursuant to the provisions of this Section 11 or under this Section 11, but only to the extent that such failure results in the Company’s forfeiture of substantive rights or defenses or the Company is prejudiced by such delay.
If any Proceeding is brought against any Indemnified Party and that Indemnified Party duly notifies the Company thereof (i) the Company will have the right, at its expense, to assume the defense thereof, including the employment of counsel; and (ii)
the Indemnified Party will have the right to employ separate counsel in the Proceeding and participate in the defense thereof, but the Indemnified Party will pay the fees and expenses of that separate counsel unless (A) the Company has agreed in
writing to pay those fees and expenses or (B) the named parties to the Proceeding (including any impleaded parties) include both the Indemnified Party and the Company, and counsel to such Indemnified Party advises the Indemnified Party in writing
that one or more legal defenses may be available to the Indemnified Party which is or are different from or additional to those available to the Company (in which case, if the Indemnified party notifies the Company in writing that the Indemnified
Party elects to employ separate counsel at the expense of the Company, the Company will not have the right to assume the defense of the Proceeding on behalf of the Indemnified Party; it being understood, however, that the Company will not, in
connection with any one Proceeding or separate but substantially similar or related Proceedings in the same jurisdiction and arising out of the same general allegations or circumstances, be liable for the fees and expenses of more than one separate
law firm (together with appropriate local counsel) at any time for all Indemnified Parties). The Company will not be liable for any settlement of any Proceeding which any Indemnified Party effects without the Company’s written consent.

  

 - 12 - 

 (c) Indemnification by Selling Holders. Each Selling Holder will, to the extent applicable law
permits, indemnify the Company and each of its Related Parties against, and hold each of those Persons harmless from and in respect of, Claims to the same extent as the indemnity from the Company to that Selling Holder in Section 11(a), but only
with respect to information that is furnished by or on behalf of that Selling Holder expressly for use in a Sellers’ Registration Statement or any prospectus (including any preliminary prospectus) forming a part thereof, or any amendment
thereof or supplement thereto. If any action or proceeding is brought against the Company or any of its Related Parties in respect of which any of those Persons may seek indemnity from a Selling Holder pursuant to this Section 11(c), that Selling
Holder will have the rights and duties given to the Company, and each of those Persons will have the rights and duties given to that Selling Holder and that Selling Holder’s Related Parties, by Section 11(b). Each Selling Holder also will, to
the extent applicable law permits, indemnify and hold harmless the underwriters of the shares of Registrable Shares offered by that Selling Holder on substantially the same basis on which the Company will indemnify and hold harmless those Persons
pursuant to Section 11(a). 
  
 (d) Contribution. If the
indemnification this Section 11 provides for is unavailable to any party intended to be indemnified pursuant to this Section 11 in respect of any Claims referred to herein, the parties who would have indemnified that party in the contemplation of
this Section 11 will, in lieu of providing that indemnification, contribute to the amount paid or payable by that party as a result of those Claims, as follows: 
  
 (i) as between the Company and the Selling Holders, on the one hand, and the underwriters of shares of Registrable Shares,
on the other hand, (A) in such proportion as is appropriate to reflect the relative benefits received by the Company and the Selling Holders and by those underwriters from the offering of those shares or, if that allocation is not permitted by
applicable law, (B) in such proportion as is appropriate to reflect not only those relative benefits, but also the relative faults of the Company and the Selling Holders and of those underwriters in connection with the statements or omissions that
resulted in those Claims, as well is any other relevant equitable considerations; and 
  
 (ii) as between the Company, on the one hand, and each Selling Holder, on the other hand, in such proportion as is appropriate to reflect the relative faults of the Company and of that Selling Holder in connection
with those statements or omissions, as well as any other relevant equitable considerations. 
  
 The relative benefits received by the Company and the Selling Holders, on the one hand, and the underwriters participating in the underwritten offering of shares of Registrable Shares, on the other hand, will be
deemed to be in the same proportion as the total proceeds from that offering (including shares of Common Stock, if any, being offered by the Company), net of underwriting discounts and commissions, but before deducting expenses, bear to the total
amount of underwriting discounts and commissions received by those underwriters in that offering, while (i) relative faults of the Company and the Selling Holders and of those underwriters will be determined by reference to, among other facts,
whether the statements or omissions that resulted in the Claims in respect of which contribution is being made are or relate to information supplied by the Company and the Selling Holders or by those underwriters and (ii) the relative faults of the
Company and of the Selling Holders will be determined by reference to, among other facts, 

  

 - 13 - 

 
(A) whether those statements or omissions are or relate to information supplied by the Company or by the Selling Holders and (B) those Persons’ relative
intent, knowledge, access to information and opportunity to correct those statements or omissions or prevent them from being made. The Company and the Selling Holders agree it would not be just or equitable if contribution pursuant to this Section
11(d) were to be determined by pro rata allocation (even if the underwriters, if any, were to be treated as one entity for this purpose) or by any other allocation method that does not take into account the equitable considerations referred to in
this Section 11(d). 
  
 (e) Limitations on Contribution. No
underwriter will be required to contribute to the Company or the Selling Holders, pursuant to Section 11(d) or otherwise, any amount in excess of the amount by which (i) the total price at which the Registrable Shares underwritten by it and
distributed to the public were offered to the public exceeds (ii) the amount of any damages it otherwise has been required to pay by reason of the statements or omissions that resulted in the Claims in respect of which contribution is being made,
and no Selling Holder will be required to contribute to the Company or any underwriter, pursuant to Section 11(d) or otherwise, any amount in excess of the amount by which (i) the total price at which that Selling Holder’s Registrable Shares
were offered to the public exceeds (ii) the amount of any damages that Selling Holder otherwise has been required to pay by reason of those statements or omissions. No Person guilty of fraudulent misrepresentation (within the meaning of Section
11(f) of the Securities Act) will be entitled to contribution from any Person who was not guilty of such fraudulent misrepresentation. If indemnification is available under this Section 11, the indemnifying parties will indemnify each indemnified
party to the full extent Sections 11 (a) and (c) provide without regard to the relative fault of any Person or any other equitable consideration referred to in Section 11(d). 
  
 12. Miscellaneous. 
  
 (a) Amendments and Waivers. Except as otherwise provided herein, the provisions of this Agreement may not be amended, modified or supplemented, and
waivers or consents to departures from the provisions hereof may not be given, unless the Company has obtained the written consent of Holders of at least 67% of the Registrable Shares then held by Holders and any such amendment, modification,
supplement, waiver or consent shall be binding on all parties hereto. 
  
 (b) Notices. All notices and other communications required or permitted to be given by any provision of this Agreement shall be in writing and mailed (certified or registered mail, postage prepaid, return receipt requested) or sent
by hand or overnight courier, by facsimile transmission (with acknowledgment received), charges prepaid and addressed to the intended recipient as follows, or to such other address or number as may be specified from time to time by like notice to
the parties: 
  
 If to the Company: 

 
 20 Newbury Street, 5th Floor 
 Boston, MA 02116

 Attention: Chief Executive Officer 
 Fax No: (617) 425-0996 
  

 - 14 - 

 with a copy to: 
  
 Wilmer Cutler Pickering Hale and Dorr LLP 
 60 State Street 
 Boston, MA 02109 
 Attention: Philip P. Rossetti, Esq. 
 Fax No: (617) 526-5000 
  
 If to a Holder, to the address or facsimile number set forth for such Holder on Schedule 1 to this Agreement. 
  
 Any party may from time to time specify a different address for notices by like notice to the
other parties. All notices and other communications given in accordance with the provisions of this Agreement shall be deemed to have been given and received (i) four (4) Business Days after the same are sent by certified or registered mail, postage
prepaid, return receipt requested, (ii) when delivered by hand or transmitted by facsimile (with acknowledgment received and, in the case of facsimile only, a copy of such notice is sent no later than the next Business Day by a reliable overnight
courier service, with acknowledgment of receipt) or (iii) one (1) Business Day after the same are sent by a reliable overnight courier service, with acknowledgment of receipt. 
  
 (c) Successors and Assigns. This Agreement will inure to the benefit of and be binding on the heirs, executors,
administrators, successors and assigns of each of the parties hereto. 
  
 (d) Counterparts. This Agreement may be executed in any number of counterparts and by the parties hereto in separate counterparts, each of which when so executed will be deemed to be an original and all of which taken together will
constitute one and the same agreement. 
  
 (e) Headings and
References. The headings in this Agreement are for convenience of reference only and will not limit or otherwise affect the meaning hereof References herein to “Sections” are to Sections of this Agreement unless otherwise indicated.

  
 (f) Governing Law. THIS AGREEMENT SHALL BE GOVERNED BY
AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK APPLICABLE TO CONTRACTS MADE AND TO BE PERFORMED WHOLLY WITHIN THAT STATE. THE PARTIES HERETO IRREVOCABLY CONSENT TO THE JURISDICTION OF THE UNITED STATES FEDERAL COURTS AND THE
STATE COURTS LOCATED IN THE STATE OF NEW YORK IN ANY SUIT OR PROCEEDING BASED ON OR ARISING UNDER THIS AGREEMENT AND IRREVOCABLY AGREE THAT ALL CLAIMS IN RESPECT OF SUCH SUIT OR PROCEEDING MAY BE DETERMINED IN SUCH COURTS. THE PARTIES HERETO
IRREVOCABLY WAIVE THE DEFENSE OF AN INCONVENIENT FORUM TO THE MAINTENANCE OF SUCH SUIT OR PROCEEDING. EACH PURCHASER WAIVES ANY RIGHT IT MAY HAVE TO A TRIAL BY JURY WITH RESPECT TO ANY ACTION OR PROCEEDING ARISING OUT OF OR RELATING TO THIS
AGREEMENT. 
  

 - 15 - 

 (g) Severability. If any one or more of the provisions herein, or the application thereof in any
circumstances, is invalid, illegal or unenforceable in any respect for any reason, the validity, legality and enforceability of that provision in every other respect and of the remaining provisions contained herein will not be in any way impaired
thereby, it being intended by each party hereto that all the rights and privileges of all parties hereto will be enforceable to the fullest extent permitted by law. 
  
 (h) Entire Agreement; Termination of Prior Registration Rights Agreement. The parties hereto intend that this
Agreement will be considered for all purposes as the final expression, and a complete and exclusive statement, of their mutual agreement and understanding in respect of the subject matter contained herein. This Agreement supersedes all prior
agreements and understandings between the parties to this Agreement with respect to that subject matter. The Prior Registration Rights Agreement is hereby terminated and of no further force or effect. 
  
 Rest of Page Intentionally Left Blank 
 Signature Page Follows 
  

 - 16 - 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Registration Rights Agreement of
the date first above written. 
  

			
	BOSTON LIFE SCIENCES, INC.
		
	 By:
	 	 /s/ Joseph P. Hernon

	 Name:
	 	 Joseph P. Hernon

	 Title:
	 	 Chief Financial Officer

					
	 Anthony Koenig
	 	 Address for Notice:

	 Print Entity Name
	 	 
			
	 By:
	 	 /s/ Arthur Koenig

	 	 Attn: c/o Tom Boucher

	 Print Name:
	 	 Arthur Koenig
	 	 Ingalls & Snyder LLC

	 Print Title:
	 	 	 	 61 Broadway

	 	 	 	 	 New York, NY 10006

	 	 	 	 	 Tel: 212-269-7897

	 	 	 	 	 Fax: 212-369-4177

  
 Security Delivery Instructions (if
different than Notice Address) 
  
 [Signature Page to Amended
and Restated Registration Rights Agreement] 
  

 - 2 - 

					
	 Thomas G. Boucher
	 	 Address for Notice:

	 Print Entity Name
	 	 
			
	 By:
	 	 /s/ Thomas G. Boucher

	 	 Attn: c/o Tom Boucher

	 Print Name:
	 	 Thomas G. Boucher
	 	 Ingalls & Snyder LLC

	 Print Title:
	 	 	 	 61 Broadway

	 	 	 	 New York, NY 10006

	 	 	 	 Tel: 212-269-7897

	 	 	 	 Fax: 212-369-4177

  
 Security Delivery Instructions (if
different than Notice Address) 
  
 [Signature Page to Amended
and Restated Registration Rights Agreement] 

					
	 Adam Janovic
	 	 Address for Notice:

	 Print Entity Name
	 	 
			
	 By:
	 	 /s/ Adam Janovic

	 	 Attn: c/o Tom Boucher

	 Print Name:
	 	 Adam Janovic
	 	 Ingalls & Snyder LLC

	 Print Title:
	 	 	 	 61 Broadway

	 	 	 	 	 New York, NY 10006

	 	 	 	 	 Tel: 212-269-7897

	 	 	 	 	 Fax: 212-369-4177

 Security Delivery Instructions (if different than Notice Address) 
  
 [Signature Page to Amended and Restated Registration Rights Agreement]

  
  

					
	 Robert L. Gipson
	 	 Address for Notice:

	 Print Entity Name
	 	 
			
	 By:
	 	 /s/ Robert L. Gipson

	 	 Attn: c/o Tom Boucher

	 Print Name:
	 	 Robert L. Gipson
	 	 Ingalls & Snyder LLC

	 Print Title:
	 	 	 	 61 Broadway

	 	 	 	 	 New York, NY 10006

	 	 	 	 	 Tel: 212-269-7897

	 	 	 	 	 Fax: 212-369-4177

  
 Security Delivery Instructions (if
different than Notice Address) 
  
 [Signature Page to Amended
and Restated Registration Rights Agreement] 

					
	 John Dougherty
	 	 Address for Notice:

	 Print Entity Name
	 	 
			
	 By:
	 	 /s/ John Dougherty

	 	 Attn: c/o Tom Boucher

	 Print Name:
	 	 John Dougherty
	 	 Ingalls & Snyder LLC

	 Print Title:
	 	 	 	 61 Broadway

	 	 	 	 	 New York, NY 10006

	 	 	 	 	 Tel: 212-269-7897

	 	 	 	 	 Fax: 212-369-4177

  
 Security Delivery Instructions (if
different than Notice Address) 
  
 [Signature Page to Amended
and Restated Registration Rights Agreement] 

					
	 Christopher Siege
	 	 Address for Notice:

	 Print Entity Name
	 	 
			
	 By:
	 	 /s/ Christopher Siege

	 	 Attn: c/o Tom Boucher

	 Print Name:
	 	 Christopher Siege
	 	 Ingalls & Snyder LLC

	 Print Title:
	 	 	 	 61 Broadway

	 	 	 	 	 New York, NY 10006

	 	 	 	 	 Tel: 212-269-7897

	 	 	 	 	 Fax: 212-369-4177

  
 Security Delivery Instructions (if
different than Notice Address) 
  
 [Signature Page to Amended
and Restated Registration Rights Agreement] 

					
	 Horace S. Boone
	 	 Address for Notice:

	 Print Entity Name
	 	 
			
	 By:
	 	 /s/ Horace S. Boone

	 	 Attn: c/o Tom Boucher

	 Print Name:
	 	 Horace S. Boone
	 	 Ingalls & Snyder LLC

	 Print Title:
	 	 	 	 61 Broadway

	 	 	 	 	 New York, NY 10006

	 	 	 	 	 Tel: 212-269-7897

	 	 	 	 	 Fax: 212-369-4177

  
 Security Delivery Instructions (if
different than Notice Address) 
  
 [Signature Page to Amended
and Restated Registration Rights Agreement] 

					
	 Steven M. Foote
	 	 Address for Notice:

	 Print Entity Name
	 	 
			
	 By:
	 	 /s/ Steven M. Foote

	 	 Attn: c/o Tom Boucher

	 Print Name:
	 	 Steven M. Foote
	 	 Ingalls & Snyder LLC

	 Print Title:
	 	 	 	 61 Broadway

	 	 	 	 	 New York, NY 10006

	 	 	 	 	 Tel: 212-269-7897

	 	 	 	 	 Fax: 212-369-4177

  
 Security Delivery Instructions (if
different than Notice Address) 
  
 [Signature Page to Amended
and Restated Registration Rights Agreement] 

					
	 Thomas DiCosto
	 	 Address for Notice:

	 Print Entity Name
	 	 
			
	 By:
	 	 /s/ Thomas DiCosto

	 	 Attn: c/o Tom Boucher

	 Print Name:
	 	 Thomas DiCosto
	 	 Ingalls & Snyder LLC

	 Print Title:
	 	 	 	 61 Broadway

	 	 	 	 	 New York, NY 10006

	 	 	 	 	 Tel: 212-269-7897

	 	 	 	 	 Fax: 212-369-4177

 Security Delivery Instructions (if different than Notice Address) 
  
 [Signature Page to Amended and Restated Registration Rights Agreement]

					
	 Heritage Mark Foundation
	 	 Address for Notice:

	 Print Entity Name
	 	 
			
	 By:
	 	 /s/ Kenneth J. Forte

	 	 Attn: c/o Tom Boucher

	 Print Name:
	 	 Kenneth J. Forte
	 	 Ingalls & Snyder LLC

	 Print Title:
	 	 Trustee
	 	 61 Broadway

	 	 	 	 	 New York, NY 10006

	 	 	 	 	 Tel: 212-269-7897

	 	 	 	 	 Fax: 212-369-4177

  
 Security Delivery Instructions (if
different than Notice Address) 
  
 [Signature Page to Amended
and Restated Registration Rights Agreement] 

					
	 Valerie A. Brackett
	 	 Address for Notice:

	 Print Entity Name
	 	 
			
	 By:
	 	 /s/ Valerie A. Brackett

	 	 Attn: c/o Tom Boucher

	 Print Name:
	 	 Valerie A. Brackett
	 	 Ingalls & Snyder LLC

	 Print Title:
	 	 	 	 61 Broadway

	 	 	 	 	 New York, NY 10006

	 	 	 	 	 Tel: 212-269-7897

	 	 	 	 	 Fax: 212-369-4177

  
 Security Delivery Instructions (if
different than Notice Address) 
  
 [Signature Page to Amended
and Restated Registration Rights Agreement] 

					
	 Thomas Gipson
	 	 Address for Notice:

	 Print Entity Name
	 	 
			
	 By:
	 	 /s/ Thomas Gipson

	 	 Attn: c/o Tom Boucher

	 Print Name:
	 	 Thomas Gipson
	 	 Ingalls & Snyder LLC

	 Print Title:
	 	 	 	 61 Broadway

	 	 	 	 	 New York, NY 10006

	 	 	 	 	 Tel: 212-269-7897

	 	 	 	 	 Fax: 212-369-4177

  
 Security Delivery Instructions (if
different than Notice Address) 
  
 [Signature Page to Amended
and Restated Registration Rights Agreement] 

					
	 Patricia Gipson
	 	 Address for Notice:

	 Print Entity Name
	 	 
			
	 By:
	 	 /s/ Patricia Gipson

	 	 Attn: c/o Tom Boucher

	 Print Name:
	 	 Patricia Gipson
	 	 Ingalls & Snyder LLC

	 Print Title:
	 	 	 	 61 Broadway

	 	 	 	 	 New York, NY 10006

	 	 	 	 	 Tel: 212-269-7897

	 	 	 	 	 Fax: 212-369-4177

  
 Security Delivery Instructions (if
different than Notice Address) 
  
 [Signature Page to Amended
and Restated Registration Rights Agreement] 

 Initial Holders: 
 (name
and address) 
  
 Ingalls & Snyder LLC 
 61 Broadway 
 New York, NY 10006 
 Attn: Arthur Koenig 
 Tel. No. 212-269-7897 
 Fax No: 212-269-4177 
  
 Ingalls & Snyder LLC 
 61 Broadway 
 New York, NY 10006 
 Attn: Thomas G. Boucher, Jr. 
 Tel.
No. 212-269-7897 
 Fax No: 212-269-4177 
  
 Ingalls & Snyder LLC 
 61 Broadway 
 New York, NY 10006 
 Attn: Adam Janovic 
 Tel. No. 212-269-7897 
 Fax No: 212-269-4177 
  
 Ingalls & Snyder LLC 
 61 Broadway 
 New York, NY 10006 
 Attn: Robert L. Gipson 
 Tel. No. 212-269-7897 
 Fax No:
212-269-4177 
  
 Ingalls & Snyder LLC 
 61 Broadway 
 New York, NY 10006 
 Attn: John Dougherty 
 Tel. No. 212-269-7897 
 Fax No: 212-269-4177 
  
 Ingalls & Snyder LLC 
 61 Broadway 
 New York, NY 10006 
 Attn: Christopher Siege 
 Tel. No.
212-269-7897 
 Fax No: 212-269-4177 

 Ingalls & Snyder LLC 
 61
Broadway 
 New York, NY 10006 
 Attn: Horace S. Boone 

Tel. No. 212-269-7897 
 Fax No: 212-269-4177 
  
 Ingalls & Snyder LLC 
 61 Broadway 
 New York, NY 10006 
 Attn: Steven M. Foote 
 Tel. No. 212-269-7897 
 Fax No:
212-269-4177 
  
 Ingalls & Snyder LLC 
 61 Broadway 
 New York, NY 10006 
 Attn: Thomas DiTosto 
 Tel. No. 212-269-7897 
 Fax No: 212-269-4177 
  
 Ingalls & Snyder LLC 
 61 Broadway 
 New York, NY 10006 
 Attn: Kenneth J. Foote 
 Tel. No.
212-269-7897 
 Fax No: 212-269-4177 
  
 Ingalls & Snyder LLC 
 61 Broadway 
 New York, NY 10006 
 Attn: Valerie L. Brackett 
 Tel. No. 212-269-7897 
 Fax No: 212-269-4177 
  
 Ingalls & Snyder LLC 
 61 Broadway 
 New York, NY 10006 
 Attn: Thomas Gipson 
 Tel. No. 212-269-7897 
 Fax No:
212-269-4177 
  
 Ingalls & Snyder LLC 
 61 Broadway 
 New York, NY 10006 
 Attn: Patricia Gipson 
 Tel. No. 212-269-7897 
 Fax No: 212-269-4177Form of Incentive Stock Option Agreement

 Exhibit 10.43 
  
 Boston Life Sciences, Inc. 
  
 [1998 Omnibus Stock Option Plan or Amended and Restated Omnibus Stock Option Plan] 
  
 Incentive Stock Option Agreement  
  
 1. Grant of Option. 
  
 This agreement (hereinafter, the “Agreement”) evidences the grant by Boston Life Sciences, Inc., a Delaware
corporation (the “Company”), on [            ], 2005 (the “Grant Date”) to
[                    ], an employee of the Company (the “Participant” or “Optionee”), of an option (the
“Option”) to purchase, in whole or in part, on the terms provided herein and in the Company’s [1998 Omnibus Stock Option Plan or Amended and Restated Omnibus Stock Option Plan] (the “Plan”), a total of
[                     ] shares (the “Shares”) of common stock, $.01 par value per share, of the Company (“Common Stock”)
at $[            ] per Share. Unless earlier terminated, this Option shall expire at 5:00 p.m., Eastern time, on
[                    ] (the “Final Exercise Date”). 
  
 It is intended that the Option evidenced by this Agreement shall be an incentive stock option as defined in Section 422 of
the Internal Revenue Code of 1986, as amended, and any regulations promulgated thereunder (the “Code”). Except as otherwise indicated by the context, the term “Participant”, as used in this Option, shall be deemed to include any
person who acquires the right to exercise this Option validly under its terms. 
  
 2. Vesting Schedule. 
  
 This Option is immediately exercisable (“Vested”) as to 33% of the original number of Shares on the Grant Date. As to the remaining 67% Shares,
this Option will become exercisable as to an additional [                    ] Shares at the end of each calendar month following the Grant
Date until the third anniversary of the Grant Date 
  
 The right
of exercise shall be cumulative so that to the extent the Option is not exercised in any period to the maximum extent permissible it shall continue to be exercisable, in whole or in part, with respect to all Shares for which it is Vested until the
earlier of the Final Exercise Date or the termination of this Option under Section 3 hereof or the Plan. 
  
 3. Exercise of Option. 
  
 (a) Form of Exercise. Each election to exercise this Option shall be in writing, signed by the Participant, and received by the Company at its
principal office, accompanied by this Agreement, and payment in full in the manner provided in the Plan. The Participant may purchase less than the number of Shares covered hereby, provided that no partial exercise of this Option may be for any
fractional share. 
  
 (b) Continuous Relationship with the
Company Required. Except as otherwise provided in this Section 3, this Option may not be exercised unless the Participant, at the time he 

  

 
or she exercises this Option, is, and has been at all times since the Grant Date, an employee or officer of, or consultant or advisor to, the Company or any
parent or subsidiary of the Company as defined in Section 424(e) or (f) of the Code (an “Eligible Participant”). 
  
 (c) Termination of Employment or Other Relationship 
  
 (i) If an Optionee ceases to be an employee, independent contractor, consultant, Scientific Advisor or director of the Company as the result of a
termination without cause (other than due to death or disability), his options will continue to vest for a period of one year pursuant to the vesting schedule established at the time the Option was granted and (A) any Options held by such Optionee
that were exercisable on the date of such termination may be exercised by the Optionee until the later of: (i) one year following the date of such termination, or, (ii) one year from the date any Option vests in the twelve month period following
such termination and (B) any Options held by such Optionee that vested during the 12 months following the date of termination may be exercised by the Optionee for a period of one year following the date of such vesting. 
  
 (ii) If an Optionee ceases to be an employee, consultant, independent
contractor, Scientific Advisor or director of the Company as the result of a voluntary resignation (other than due to death or disability), his options will continue to vest for a period of one year pursuant to the vesting schedule established at
the time the Option was granted and provided that the Optionee has been an employee, consultant, independent contractor, Scientific Advisor or director of the Company for at least three years and has signed a non-compete agreement with the Company
(such agreement to include biotechnology companies, academic and/or research organizations encompassing biotechnology, and venture capital companies in the biotechnology sector), and (A) any Options held by such Optionee that were exercisable on the
date of such resignation may be exercised by the Optionee until the later of: i) one year following the date of such resignation, or ii) one year from the date any Option vests in the twelve month period following such resignation and (B) any
Options held by such Optionee that vested during the 12 months following the date of resignation may be exercised by the Optionee for a period of one year following the date of such vesting provided, that, if the Optionee dies within such one-year
period following termination of employment or other relationship, the Option (to the extent exercisable at the time of death) shall be exercisable by the Optionee’s Beneficiary for a period of one (1) year following the Optionee’s death
(but in no event after the expiration date of the Option), and shall thereafter terminate. 
  
 (iii) Death or Disability.    If the Optionee’s employment or other relationship with the Company is terminated because of death or disability, the Optionee (or, where applicable, the
Beneficiary) will be entitled to exercise the Option with respect to the total number of shares of Stock subject to such Option and without regard to the extent to which such Option was exercisable at the time of the termination of employment or
other relationship due to death or disability for a period of one (1) year following the Optionee’s death or termination of employment or other relationship due to death or disability (but in no event after the expiration date of the Option),
and the Option shall thereafter terminate. 
  
 (iv) Discharge
for Cause. If the Participant, prior to the Final Exercise Date, is discharged by the Company for “cause” (as defined below), the right to exercise this Option shall terminate immediately upon the effective date of such discharge.
“Cause” shall mean willful misconduct by the Participant or willful failure by the Participant to perform his or her responsibilities to the Company (including, without limitation, breach by the Participant of any provision of any
employment, consulting, advisory, nondisclosure, non-competition or other similar agreement between the Participant and the Company), as determined by the Company, which determination shall be conclusive. The Participant shall be considered to have
been discharged for “Cause” if the Company determines, within 30 days after the Participant’s resignation, that discharge for cause was warranted. 
  
 4. Agreement in Connection with Public Offering. 
  
 The Participant agrees, in connection with the initial underwritten public
offering of the Company’s securities pursuant to a registration statement under the Securities Act, (i) not to sell, make short sale of, loan, grant any Options for the purchase of, or otherwise dispose of any shares of Common Stock held by the
Participant (other than those shares included in the offering) without the prior written consent of the Company or the underwriters managing such initial underwritten public offering of the Company’s securities for a period of 180 days from the
effective date of such registration statement, and (ii) to execute any agreement reflecting clause (i) above as may be requested by the Company or the managing underwriters at the time of such offering. 
  

 - 2 - 

 5. Tax Matters. 
  
 (a) Withholding. No Shares will be issued pursuant to the exercise of this Option unless and until the Participant
pays to the Company, or makes provision satisfactory to the Company for payment of, any federal, state or local withholding taxes required by law to be withheld in respect of this Option. 
  
 (b) Disqualifying Disposition. If the Participant disposes of Shares acquired upon exercise of this Option within two
years from the Grant Date or one year after such Shares were acquired pursuant to exercise of this Option, the Participant shall notify the Company in writing of such disposition. 
  
 6. Nontransferability of Option. 
  
 This Option may not be sold, assigned, transferred, pledged or otherwise encumbered by the Participant, either voluntarily
or by operation of law, except by will or the laws of descent and distribution, and, during the lifetime of the Participant, this Option shall be exercisable only by the Participant. 
  
 7. Provisions of the Plan. 
  
 This Option is subject to the provisions of the Plan, a copy of which is furnished to the Participant with this Option.

  
 IN WITNESS WHEREOF, the Company has caused this Option to be
executed under its corporate seal by its duly authorized officer. This Option shall take effect as a sealed instrument. 
  

					
	 	 	BOSTON LIFE SCIENCES, INC.
			
	Dated:                               ,
200    	 	By:	 	  

	 	 	Name:	 	 
	 	 	Title:	 	 

  

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 PARTICIPANT’S ACCEPTANCE 
  
 The undersigned hereby accepts the foregoing Option and agrees to the terms and conditions thereof. The undersigned hereby
acknowledges receipt of a copy of the Company’s [1998 Omnibus Stock Option Plan or Amended and Restated Omnibus Stock Option Plan]. 
  

			
	PARTICIPANT:
	
	

		
	Address:	 	  

	 	 	  

  

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