Document:

exv10w1

EXHIBIT 10.1

PORTIONS OF THIS EXHIBIT MARKED BY AN (***) HAVE BEEN OMITTED
PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.

AMENDMENT

(Spain and Benelux)

This amendment (“Amendment”) amends the Global Access Agreement between Amadeus IT Group, S.A. and
eBookers Limited dated June 1, 2004 (the “Agreement”) and is effective February 1, 2008 (the
“Amendment Effective Date”).

WHEREAS, the Parties desire to add the countries of Spain and Benelux as markets under the
Agreement subject to the terms and conditions of this Amendment;

IT IS AGREED:

	1.	 	Spain and Benelux. The countries of Spain and Benelux are added as countries under
Exhibit 2 of the Agreement. EBOOKERS Locations in such countries will come under the
Agreement.
	 
	2.	 	Second Additional Bonus. AMADEUS will pay EBOOKERS a payment of (***) within 30 days
of EBOOOKERS invoice in exchange for EBOOKERS producing an additional (***) Net Segments above
the current Total Target (i.e., (***) Net Segments as stated in Section 5 of the Complimentary
and Amendment Agreement dated 1st of September, 2006) for a new Total Target of
(***) Net Segment. In the event the new Total Target is not met at the end of the current
Term (i.e., 31st of December 2009 as per the Complimentary and Amendment Agreement)
then EBOOKERS will repay AMADEUS the amount of (***) per Net Segment short of the new Total
Target down to the current Total Target of (***) Net Segments. The repayment obligations with
respect to the Additional Bonus as described in Section 7 of the Complementary and Amendment
Agreement will remain in effect for Net Segments short of the current Total Target of (***)
Net Segments.
	 
	3.	 	Product Fund. The Product Fund may be used to help offset any start-up costs for
implementations in Spain and Benelux.
	 
	4.	 	Rules of Engagement. Section 14 of the Complimentary and Amendment Agreement (“Rules
of Engagement...”) will apply to this Amendment.
	 
	5.	 	All other terms and conditions of the Agreement remain in full force and effect except as
modified by the above.

	 	 	 	 	 	 	 	 	 	 	 
	Amadeus IT Group, S.A.	 	 	 	EBOOKERS LIMITED	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	By:

	 	/s/ Gillian Gibson
	 	 	 	By:
	 	/s/ Alan Josephs	 	 
	 

	 	 

	 	 	 	 	 	 

	 	 
	Name:

	 	Gillian Gibson
	 	 	 	Name:
	 	Alan Josephs	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	Title:

	 	Group Vice President
	 	 	 	Title:
	 	MD	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	Date:

	 	09/09/08
	 	 	 	Date:
	 	28/05/08EX-10.1

Exhibit 10.1

STOCK PURCHASE AGREEMENT

     This Stock Purchase Agreement is dated as of August 8, 2008 (this “Agreement”),
between OPKO Health, Inc., a Delaware corporation (the “Company”), and the purchasers
listed on Annex A hereto (collectively, the “Purchasers”).

     WHEREAS, the Company desires to sell to Purchasers, and Purchasers desire to purchase from the
Company, shares of the Company’s common stock, par value $.01 per share (the “Common
Stock”), on the terms and subject to the conditions set forth in this Agreement (the
“Transaction”).

     WHEREAS, the Purchase Price and the Shares (as hereinafter defined) issued shall be allocated
among the Purchasers in accordance with Annex A. 

     NOW, THEREFORE, in consideration of the premises and the mutual covenants contained in this
Agreement and for other good and valuable consideration, the receipt and sufficiency of which are
hereby acknowledged, and intending to be legally bound, the parties agree as follows:

Article 1

Purchase and Sale of Common Stock

     1.1 Purchase and Sale of the Shares. Subject to the terms and conditions hereof, the
Company hereby agrees to issue and sell to Purchasers, and Purchasers hereby agree to purchase from
the Company, 13,513,514 shares of Common Stock (the “Shares”) at a purchase price of $1.11 per
share for an aggregate purchase price of $15 million (the “ Purchase Price”).

     1.2 Closing. The closing of the issuance and sale of the Shares (the
“Closing”) shall take place at the Company’s offices in Miami, Florida on, or as soon as
possible following, the date which is twenty (20) days after the Company first mails to
stockholders an Information Statement on Schedule 14C notifying stockholders that the Transaction
was approved by the written consent of stockholders holding a majority of the voting power of the
outstanding capital stock of the Company (the “Closing”). As payment in full for the Shares being
purchased by them at the Closing, Purchasers shall pay to the Company the Purchase Price by wire
transfer.

Article 2

Additional Agreements

     The Company and Purchasers shall cooperate with each other and use their respective
commercially reasonable best efforts to take or cause to be taken all actions, and do or cause to
be done all things, necessary, proper or advisable under this Agreement and applicable laws and
regulations to consummate and make effective the sale of the Shares (the “Sale”) and the
other transactions contemplated by this Agreement as soon as practicable, including preparing and
filing as promptly as practicable all documentation to effect all necessary applications, notices,
petitions, filings and other documents and to obtain as promptly as practicable all permits,
consents, approvals and authorizations necessary or advisable to be obtained from any third party
and/or any governmental entity in order to consummate the Sale or any of the other
transactions contemplated by this Agreement.

1

 

Article 3

Representations and Warranties of the Company

     The Company represents and warrants to Purchasers as of the date hereof as follows:

     3.1 Authorization of Agreements, etc. The execution and delivery by the Company of
this Agreement, the performance by the Company of its obligations hereunder, and the issuance, sale
and delivery of the Shares have been duly authorized by all requisite corporate action and will not
result in any violation of, be in conflict with, or constitute a default under, with or without the
passage of time or the giving of notice: (a) any provision of the Company’s Certificate of
Incorporation, as amended, or Bylaws, as amended; (b) any provision of any judgment, decree or
order to which the Company is a party or by which it is bound; (c) any material contract or
agreement to which the Company is a party or by which it is bound; or (d) any statute, rule or
governmental regulation applicable to the Company, except where such violation, conflict, or
default would not have a material adverse effect on the Company.

     3.2 Valid Issuance of Common Stock. The Shares have been duly authorized and, when
issued, sold and delivered in accordance with this Agreement for the consideration expressed herein
will be validly issued, fully paid and nonassessable with no personal liability attaching to the
ownership thereof and will be free and clear of all liens, charges and encumbrances of any nature
whatsoever except for restrictions on transfer under this Agreement and under applicable Federal
and state securities laws.

     3.3 Validity. This Agreement has been duly executed and delivered by the Company and
constitutes the legal, valid and binding obligation of the Company, enforceable in accordance with
its terms except (i) as limited by applicable bankruptcy, insolvency, reorganization, moratorium,
and other laws of general application affecting enforcement of creditors’ rights generally, and
(ii) as limited by laws relating to the availability of specific performance, injunctive relief, or
other equitable remedies.

     3.4 Brokers and Finders. Neither the Company nor any of its subsidiaries, officers,
directors or employees has employed any broker or finder or incurred any liability for any
brokerage fees, commissions or finders’ fees in connection with the Sale or the other transactions
contemplated by this Agreement.

Article 4

Representations and Warranties of Purchasers

     Each of the Purchasers hereby severally and not jointly represents and warrants to the Company
as of the date hereof as follows:

2

 

     4.1 Validity. This Agreement has been duly executed and delivered by Purchaser and
constitutes the legal, valid and binding obligation of Purchaser, enforceable in accordance with
its terms except:

          (a) as limited by applicable bankruptcy, insolvency, reorganization, moratorium, and other
laws of general application affecting enforcement of creditors’ rights generally; and

          (b) as limited by laws relating to the availability of specific performance, injunctive
relief, or other equitable remedies.

     4.2 Investment Representations.

          (a) Purchaser is an “accredited investor” within the meaning of Rule 501 of Regulation D under
the Securities Act of 1933, as amended (the “Securities Act”) and was not organized for the
specific purpose of acquiring the Shares;

          (b) Purchaser has sufficient knowledge and experience in investing in companies similar to the
Company in terms of the Company’s stage of development so as to be able to evaluate the risks and
merits of its investment in the Company and it is able financially to bear the risks thereof;

          (c) it is the present intention that the Shares being purchased by Purchaser are being
acquired for Purchaser’s own account for the purpose of investment and not with a present view to
or for sale in connection with any distribution thereof;

          (d) Purchaser understands that:

               (i) the Shares have not been registered under the Securities Act by reason of their issuance
in a transaction exempt from the registration requirements of the Securities Act pursuant to
Section 4(2) thereof or Rule 505 or 506 promulgated under the Securities Act;

               (ii) the Shares must be held indefinitely unless a subsequent disposition thereof is
registered under the Securities Act or is exempt from such registration;

               (iii) the Shares will bear a legend to such effect; and

               (iv) the Company will make a notation on its transfer books to such effect; and

          (e) the Company has made available to Purchaser all documents and information that the
Purchaser has requested relating to an investment in the Company.

     4.3 Brokers and Finders. The Purchaser has not employed any broker or finder or
incurred any liability for any brokerage fees, commissions or finders’ fees in connection with the
Sale or the other transactions contemplated by this Agreement.

3

 

Article 5

Miscellaneous

     5.1 Lock-Up. Each of the Purchasers hereby irrevocably agrees that until the second
anniversary of the date of Closing, he she or it will not, without the prior written consent of the
Company, directly or indirectly:

          (a) Offer for sale, sell, pledge or otherwise dispose of (or enter into any transaction or
device that is designed to, or could be expected to, result in the disposition by any person at any
time in the future, of any of the Shares;

          (b) Enter into any swap or other derivatives transaction that transfers to another, in whole
or in part, any of the economic benefits or risks of ownership of the Shares, or

          (c) Publicly disclose the intention to do any of the foregoing, for a period commencing on the
date hereof and ending on the second anniversary of the date hereof.

     5.2 Legend. Each certificate that represents Shares shall have conspicuously endorsed
thereon the following legends:

THIS STOCK HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
“SECURITIES ACT”), OR ANY STATE SECURITIES LAWS. THIS STOCK MAY NOT BE OFFERED OR
TRANSFERRED BY SALE, ASSIGNMENT, PLEDGE OR OTHERWISE UNLESS (A) A REGISTRATION
STATEMENT FOR THE STOCK UNDER THE SECURITIES ACT IS IN EFFECT OR (B) THE COMPANY HAS
RECEIVED AN OPINION OF COUNSEL, WHICH OPINION IS SATISFACTORY TO THE COMPANY, TO THE
EFFECT THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES ACT OR THE
RELEVANT STATE SECURITIES LAWS.

THIS STOCK IS SUBJECT TO RESTRICTIONS ON RESALE PURSUANT TO THAT CERTAIN STOCK
PURCHASE AGREEMENT WITH THE COMPANY DATED AUGUST 8, 2008 AND MAY NOT BE OFFERED OR
TRANSFERRED BY SALE, ASSIGNMENT, PLEDGE OR OTHERWISE WITHOUT THE PRIOR WRITTEN
CONSENT OF THE COMPANY.

     5.3 Brokerage. Each party hereto will indemnify and hold harmless the other against
and in respect of any claim for brokerage or other commissions relative to this Agreement or to the
transactions contemplated hereby, based in any way on agreements, arrangements or understandings
made or claimed to have been made by such party with any third party.

     5.4 Parties in Interest. All representations, covenants and agreements contained in
this Agreement by or on behalf of any of the parties hereto shall bind and inure to the benefit of
the respective successors and assigns of the parties hereto whether so expressed or not.

4

 

     5.5 Notices. All notices, requests, consents, demands, and other communications under
this Agreement shall be in writing and shall be deemed to have been duly given on the date of
service if served personally on the party to whom notice is to be given, on the date of transmittal
of services via telecopy to the party to whom notice is to be given (with a confirming copy
delivered within 24 hours thereafter), or on the third day after mailing if mailed to the party to
whom notice is to be given, by first class mail, registered or certified, postage prepaid, or
overnight mail via a nationally recognized courier providing a receipt for delivery and properly
addressed as follows:

	 	 	 
	If to the Company:

	 	OPKO Health, Inc.
	 

	 	4400 Biscayne Blvd.
	 

	 	Suite 1180
	 

	 	Miami, FL 33137
	 

	 	Attn: Kate Inman, Esq.
	 
	 	 
	If to any of the Purchasers:

	 	To the address specified on the signature pages hereto.

Any party may change its address for purposes of this paragraph by giving notice of the new address
to each of the other parties in the manner set forth above.

     5.6 Governing Law. This Agreement shall be governed by and construed in accordance
with the laws of the State of Florida for all purposes and in all respects, without regard to the
conflict of law provisions of such state.

     5.7 Entire Agreement. This Agreement constitutes the sole and entire agreement of the
parties with respect to the subject matter hereof.

     5.8 Counterparts. This Agreement may be executed in two or more counterparts
(including facsimiles), each of which shall be deemed an original, but all of which together shall
constitute one and the same instrument.

     5.9 Amendments and Waivers. This Agreement may be amended or modified, and provisions
hereof may be waived, only with the written consent of the Company and the Purchasers.

     5.10 Severability. If any provision of this Agreement shall be declared void or
unenforceable by any judicial or administrative authority, the validity of any other provision and
of the entire Agreement shall not be affected thereby.

     5.11 Titles and Subtitles. The titles and subtitles used in this Agreement are for
convenience only and are not to be considered in construing or interpreting any term or provision
of this Agreement.

5

 

     NOW THEREFORE, the Company and Purchasers have executed this Stock Purchase Agreement as of
the date first above written.

OPKO HEALTH, INC.

By: /s/ Rao Uppaluri                    

Name: Rao Uppaluri

Title: Senior Vice President; Chief Financial Officer

6

 

INVESTORS

Frost Gamma Investments Trust

By: /s/ Phillip Frost, M.D.                    

Name: Phillip Frost, M.D.

Title: Trustee

Address:

7

 

Hsu Gamma Investment, L.P.

By: /s/ Jane Hsiao                    

Name: Jane Hsiao

Title: General Partner

Address:

8

 

The Jacqueline Simkin Trust,

as amended and restated

December 16, 2003

By: /s/ Jacqueline Simkin                    

Name: Jacqueline Simkin

Title: Trustee

Address:

9

 

/s/ Rao Uppaluri                    

Rao Uppaluri

Address:

10

 

Horberg Enterprises Limited Partnership

By:  /s/ Howard Todd Horberg                    

Name: Howard Todd Horberg

Title: President of Horberg Ventures (the General Partner)

Address:

11

 

Horberg Family Limited Partnership

By:  /s/ David Horberg                    

Name: David Horberg

Title: President

Address:

12

 

By: /s/ F. Mitchell Howell                    

Name: F. Mitchell Howell

Address:

13

 

By: /s/ Mara Schainuck                    

Name: Mara Schainuck

Address:

14

 

By: /s/ Glenn L. Halpryn                    

Name: Glenn L. Halpryn

Address:

15

 

IVC Investors, LLLP

By: /s/ Ernest M. Halpryn                    

Name: Ernest M. Halpryn

Title: President

Address:

16

 

By: /s/ Steven Jerry Glauser                    

Name: Steven Jerry Glauser

Address:

17

 

ANNEX A

	 	 	 	 	 	 	 	 	 	 	 	 	 
	 
	 	 	 	 	Number of Shares of	 	 	 	 	 	 
	 	Purchaser	 	 	Common Stock	 	 	 	Purchase Price	 	 
	 	Frost Gamma Investments
Trust
	 	 	 	 	 	 	 	 	 	 	 
	 	Hsu Gamma Investment, L.P.
	 	 	 	 	 	 	 	 	 	 	 
	 	Rao Uppaluri
	 	 	 	 	 	 	 	 	 	 	 
	 	F. Mitchell Howell
	 	 	 	 	 	 	 	 	 	 	 
	 	Mara Schainuck
	 	 	 	 	 	 	 	 	 	 	 
	 	Glenn L. Halpryn
	 	 	 	 	 	 	 	 	 	 	 
	 	IVC Investors, LLLP
	 	 	 	 	 	 	 	 	 	 	 
	 	Steven Jerry Glauser
	 	 	 	 	 	 	 	 	 	 	 
	 	Horberg Enterprises Limited
Partnership
	 	 	 	 	 	 	 	 	 	 	 
	 	Horberg Family Limited
Partnership
	 	 	 	 	 	 	 	 	 	 	 
	 	The Jacqueline Simkin Trust,
as amended and restated
December 16, 2003
	 	 	 	 	 	 	 	 	 	 	 
	 	Total:
	 	 	 	13,513,514	 	 	 	$	15,000,000.54	 	 
	 

18

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