Document:

<PAGE>
                                                                               .
                                                                               .
                                                                               .
                                                                     Exhibit 4.1

                        [AMICUS THERAPEUTICS, INC. LOGO]
NUMBER                                                                    SHARES
A

<Table>
<S>                                <C>                           <C>
INCORPORATED UNDER THE LAWS        AMICUS THERAPEUTICS, INC.                       CUSIP 03152W 10 9
OF THE STATE OF DELAWARE                                         SEE REVERSE FOR CERTAIN DEFINITIONS
</Table>

THIS CERTIFIES THAT

is the owner of

             FULLY PAID AND NON-ASSESSABLE SHARES OF COMMON STOCK,
                          $.01 PAR VALUE PER SHARE, OF

----------=================AMICUS THERAPEUTICS, INC.=================---------

transferable on the books of the Corporation by said owner in person or by his
duly authorized attorney upon the surrender of this certificate properly
endorsed. This certificate is not valid until countersigned by the Transfer
Agent and registered by the Registrar.

         Witness the facsimile of the Corporation's seal and the facsimile
signatures of its duly authorized officers.

Dated:

<Table>
<S>                              <C>                                 <C>
-----------------------          --------------------------          -------------------------------------
/s/ Illegible Signature          [AMICUS THERAPEUTICS SEAL]                 /s/ Illegible Signature
       SECRETARY                                                     PRESIDENT AND CHIEF EXECUTIVE OFFICER
</Table>

                          COUNTERSIGNED AND REGISTERED
                                 AMERICAN STOCK TRANSFER & TRUST COMPANY
                                             (New York, NY)
                                                    TRANSFER AGENT AND REGISTRAR
BY:

                                                            AUTHORIZED SIGNATURE

<PAGE>

                           AMICUS THERAPEUTICS, INC.

The Corporation will furnish without charge to each stockholder who so requests
a statement of the powers, designations, preferences and relative,
participating, optional, or other special rights of each class of stock or
series thereof and the qualifications, limitations or restrictions of such
preferences and/or rights. Any such request should be addressed to the Secretary
of the Corporation at its principal place of business.

The following abbreviations, when used in the inscription on the face of this
certificate, shall be construed as though they were written out in full
according to applicable laws or regulations:

<Table>
<Caption>
<S>                                                <C>
  TEN COM  -- as tenants in common                 UNIF GIFT MIN ACT--          Custodian
                                                                      ----------          --------
  TEN ENT  -- as tenants by the entireties                              (Cust)             (Minor)
  JT TEN   -- as joint tenants with right of                  under Uniform Gifts to Minors
              survivorship and not as tenants
              in common                               Act
                                                          ----------------------------------------
                                                                           (State)

                                                   UNIF TRANS MIN ACT--          Custodian
                                                                        ---------          --------
                                                                          (Cust)            (Minor)
                                                                        under Uniform Transfers to Minors
                                                                    Act
                                                                       ----------------------------------
                                                                                     (State)
</Table>

     Additional abbreviations may also be used though not in the above list.

For value received, ____________________________________________hereby sell(s),
 assign(s) and transfer(s) unto

PLEASE INSERT SOCIAL SECURITY OR OTHER
  IDENTIFYING NUMBER OF ASSIGNEE

--------------------------------------

--------------------------------------

--------------------------------------------------------------------------------
 (PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING ZIP CODE, OF ASSIGNEE)

--------------------------------------------------------------------------------

--------------------------------------------------------------------------------

                                                                        shares
------------------------------------------------------------------------
of the common stock represented by the within Certificate, and do hereby
irrevocably constitute and appoint

                                                                        Attorney
------------------------------------------------------------------------
to transfer the said stock on the books of the within named Corporation with
full power of substitution in the premises.

Dated
      ---------------------------

                   ------------------------------------------------------------
                             THE SIGNATURE(S) TO THIS ASSIGNMENT MUST CORRESPOND
                   NOTICE:   WITH THE  NAME(S) AS WRITTEN UPON THE FACE OF
                             THE CERTIFICATE IN EVERY PARTICULAR, WITHOUT
                             ALTERATION OR ENLARGEMENT OR ANY CHANGE WHATEVER.

SIGNATURE(S) GUARANTEED

By
  -------------------------------------------------------------------------
THE SIGNATURE(S) MUST BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION,
(Banks, Stockbrokers, Savings and Loan Associations and Credit Unions) WITH
MEMBERSHIP IN AN APPROVED SIGNATURE GUARANTEE MEDALLION PROGRAM PURSUANT TO
S.E.C. RULE 17Ad-15.<PAGE>
                                                                    Exhibit 10.2

                               AMICUS THERAPEUTICS

                           2007 EQUITY INCENTIVE PLAN

1.       PURPOSE

         This Plan is intended to encourage ownership of Common Stock by
employees, consultants and directors of the Company and its Affiliates and to
provide additional incentive for them to promote the success of the Company's
business through the grant of Awards of shares of the Company's Common Stock.
The Plan is intended to be an incentive stock option plan within the meaning of
Section 422 of the Code but not all Awards granted hereunder are required to be
Incentive Options.

2.       DEFINITIONS

         As used in the Plan the following terms shall have the respective
meanings set out below, unless the context clearly requires otherwise:

         2.1. "Accelerate", "Accelerated", and "Acceleration", when used with
respect to an Option, means that as of the time of reference such Option will
become exercisable with respect to some or all of the shares of Common Stock for
which it was not then otherwise exercisable by its terms, and, when used with
respect to Restricted Stock or Restricted Stock Units, as the case may be, means
that the Risk of Forfeiture otherwise applicable to such Restricted Stock or
Restricted Stock Units, as the case may be, shall expire with respect to some or
all of the shares of Restricted Stock or some or all of the Restricted Stock
Units, as the case may be, then still otherwise subject to the Risk of
Forfeiture.

         2.2. "Acquiring Person" means, with respect to any Transaction or any
acquisition described in clause (ii) of the definition of Change of Control, the
surviving or acquiring person or entity in connection with such Transaction or
acquisition, as the case may be, provided that if such surviving or acquiring
person or entity is controlled, directly or indirectly, by any other person or
entity (an "Ultimate Parent Entity") that is not itself controlled by any entity
or person that is not a natural person, the term "Acquiring Person" shall mean
such Ultimate Parent Entity.

         2.3. "Affiliate" means, with respect to any person or entity, any other
person or entity controlling, controlled by or under common control with the
first person or entity.

         2.4. "Applicable Voting Control Percentage" means (i) at any time prior
to the initial public offering of the Company, a percentage greater than fifty
percent (50%) and (ii) at any time from and after the initial public offering of
the Company, twenty percent (20%).

         2.5. "Award" means any grant or sale pursuant to the Plan of Options,
Restricted Stock, Restricted Stock Units or Stock Grants.

         2.6. "Award Agreement" means an agreement between the Company and the
recipient of an Award, setting forth the terms and conditions of the Award.

         2.7. "Beneficial Ownership" has the meaning ascribed to such term in
Rule 13d-3, or any successor rule thereto, promulgated by the Securities and
Exchange Commission pursuant to the Exchange Act.

<PAGE>
                                      -2-

         2.8.     "Board" means the Company's board of directors.

         2.9. "Change of Control" means (i) the closing of any Sale of the
Company Transaction or (ii) the direct or indirect acquisition, in a single
transaction or a series of related transactions, by any person or Group (other
than the Company or a Controlled Affiliate of the Company) of Beneficial
Ownership of previously outstanding shares of capital stock of the Company if
(A) immediately after such acquisition, such person or Group, together with
their respective Affiliates, shall own or hold shares of capital stock of the
Company possessing at least the Applicable Voting Control Percentage of the
total voting power of the outstanding capital stock of the Company and (B)
immediately prior to such acquisition, such person or Group, together with their
respective Affiliates, did not own or hold shares of capital stock of the
Company possessing at least the Applicable Voting Control Percentage of the
total voting power of the outstanding capital stock of the Company.
Notwithstanding anything expressed or implied in the foregoing provisions of
this definition to the contrary, any direct or indirect acquisition referred to
in clause (ii) above in this definition shall not be treated as a Change of
Control if, at any time prior to or after such direct or indirect acquisition, a
majority of the members of the board of directors of the Company as constituted
immediately prior to such direct or indirect acquisition consent in writing to
exclude such direct or indirect acquisition from the scope of this definition.

         2.10. "Code" means the Internal Revenue Code of 1986, as amended from
time to time, or any successor statute thereto, and any regulations issued from
time to time thereunder.

         2.11. "Controlled Affiliate" means, with respect to any person or
entity, any other person or entity that is controlled by such person or entity.

         2.12. "Committee" means any committee of the Board delegated
responsibility by the Board for the administration of the Plan, as provided in
Section 5 of the Plan. For any period during which no such committee is in
existence, the term "Committee" shall mean the Board and all authority and
responsibility assigned the Committee under the Plan shall be exercised, if at
all, by the Board.

         2.13. "Common Stock" means common stock, par value $0.01 per share, of
the Company.

         2.14. "Company" means Amicus Therapeutics, Inc., a corporation
organized under the laws of the State of Delaware.

         2.15. "Exchange Act" means the Securities Exchange Act of 1934, as
amended.

         2.16. "Grant Date" means the date as of which an Option is granted, as
determined under Section 7.1(a).

         2.17. "Group" has the meaning ascribed to such term in Section 13(d)(3)
of the Exchange Act or any successor section thereto.

         2.18. "Incentive Option" means an Option which by its terms is to be
treated as an "incentive stock option" within the meaning of Section 422 of the
Code.

<PAGE>

                                      -3-

         2.19. "Market Value" means the value of a share of Common Stock on a
particular date determined by such methods or procedures as may be established
by the Committee. Unless otherwise determined by the Committee, the Market Value
of Common Stock as of any date is the closing price for the Common Stock as
reported on the NASDAQ Global market (or on any other national securities
exchange on which the Common Stock is then listed) for that date or, if no
closing price is reported for that date, the closing price on the next preceding
date for which a closing price was reported. For purposes of Awards granted as
of the effective date of the Company's initial public offering, Market Value
shall be the price at which the Company's Common Stock is offered to the public
in its initial public offering.

         2.20. "Nonstatutory Option" means any Option that is not an Incentive
Option.

         2.21. "Option" means an option granted under the Plan to purchase
shares of Common Stock.

         2.22. "Optionee" means an employee, consultant or director of the
Company to whom an Option shall have been initially granted under the Plan.

         2.23. "Participant" means any holder of an outstanding Award under the
Plan.

         2.24. "Plan" means this 2007 Equity Incentive Plan of the Company, as
amended and in effect from time to time.

         2.25. "Restricted Stock" means a grant or sale pursuant to the Plan of
shares of Common Stock to a Participant subject to a Risk of Forfeiture.

         2.26. "Restricted Stock Units" means rights granted pursuant to the
Plan to receive shares of Common Stock at the close of a Restriction Period,
subject to a Risk of Forfeiture.

         2.27. "Restriction Period" means the period of time, established by the
Committee in connection with an Award of Restricted Stock or Restricted Stock
Units, during which the shares of Restricted Stock or Restricted Stock Units are
subject to a Risk of Forfeiture described in the applicable Award Agreement.

         2.28 "Risk of Forfeiture" means a limitation on the right of a
Participant to retain an Award of Restricted Stock or Restricted Stock Units,
including a right in the Company to reacquire such Restricted Stock at less than
its then Market Value and/or the forfeiture of Restricted Stock Units held by a
Participant, arising because of the occurrence or non-occurrence of specified
events or conditions.

         2.29 "Sale of the Company Transaction" means any Transaction in which
the stockholders of the Company immediately prior to such Transaction, together
with any and all of such stockholders' Affiliates, do not own or hold,
immediately after consummation of such Transaction, shares of capital stock of
the Acquiring Person in connection with such Transaction possessing at least a
majority of the total voting power of the outstanding capital stock of such
Acquiring Person.

         2.30     "Securities Act" means the Securities Act of 1933, as amended.

<PAGE>

                                      -4-

         2.31 "Stock Grant" means the grant pursuant to the Plan of shares of
Common Stock not subject to restrictions or other forfeiture conditions.

         2.27. "Ten Percent Owner" means a person who owns, or is deemed within
the meaning of Section 422(b)(6) of the Code to own, stock possessing more than
10% of the total combined voting power of all classes of stock of the Company
(or any parent or subsidiary corporations of the Company, as defined in Section
424(e) and (f), respectively, of the Code). Whether a person is a Ten Percent
Owner shall be determined with respect to each Option based on the facts
existing immediately prior to the Grant Date of such Option.

         2.28. "Transaction" means any merger or consolidation of the Company
with or into another person or entity or the sale or transfer of all or
substantially all of the assets of the Company, in each case in a single
transaction or in a series of related transactions.

3.       TERM OF THE PLAN

         Unless the Plan shall have been earlier terminated by the Board, Awards
may be granted under this Plan at any time in the period commencing on the
effective date of approval of the Plan by the Board and ending immediately prior
to the tenth anniversary of the earlier of the adoption of the Plan by the Board
or approval of the Plan by the Company's stockholders. Awards granted pursuant
to the Plan within such period shall not expire solely by reason of the
termination of the Plan. Awards of Incentive Options granted prior to
stockholder approval of the Plan are hereby expressly conditioned upon such
approval, but in the event of the failure of the stockholders to approve the
Plan shall thereafter and for all purposes be deemed to constitute Nonstatutory
Options.

4.       STOCK SUBJECT TO THE PLAN

         Subject to the provisions of Section 8 of the Plan, at no time shall
the number of shares of Common Stock issued pursuant to or subject to
outstanding Awards granted under the Plan (including, without limitation,
pursuant to Incentive Options), nor the number of shares of Common Stock issued
pursuant to Incentive Options, exceed the sum of (a) Nine Hundred Sixty Six
Thousand Six Hundred Sixty Seven (966,667) shares of Common Stock plus (b) an
annual increase to be added, automatically and without further action on January
1 of each year equal to the lesser of (i) Twenty Six Thousand Six Hundred Sixty
Seven (26,667) shares of common stock and (ii) one percent (1.0%) of the
Company's outstanding equity on a fully diluted basis, calculated by treating
all outstanding warrants, stock options and convertible securities of the
Company, whether or not then vested or exercisable, as if they had been
exercised for or converted into the full number of shares of capital stock of
the Company subject to such outstanding warrants, stock options and convertible
securities), on the December 31 that immediately precedes such January 1;
provided, however, that the Board may, at any time and on any one or more
occasions, take action to waive the annual increase set forth in clause (b), in
whole or in part. For purposes of applying the foregoing limitation, (x) if any
Option expires, terminates, or is cancelled for any reason without having been
exercised in full, or if any Award of Restricted Stock is forfeited, the shares
not purchased by the Participant or forfeited by the Participant shall again be
available for Awards thereafter to be granted under the Plan, and (y) if any
Option is exercised by delivering previously

<PAGE>
                                      -5-

owned shares in payment of the exercise price therefor, only the net number of
shares, that is, the number of shares issued minus the number received by the
Company in payment of the exercise price, shall be considered to have been
issued pursuant to an Award granted under the Plan. Shares of Common Stock
issued pursuant to the Plan may be either authorized but unissued shares or
shares held by the Company in its treasury.

5.       ADMINISTRATION

         The Plan shall be administered by the Committee; provided, however,
that at any time and on any one or more occasions the Board may itself exercise
any of the powers and responsibilities assigned the Committee under the Plan and
when so acting shall have the benefit of all of the provisions of the Plan
pertaining to the Committee's exercise of its authorities hereunder; and
provided further that the Committee may delegate to an executive officer or
officers the authority to grant Awards hereunder to employees who are not
officers, and to consultants, in accordance with such guidelines as the
Committee shall set forth at any time or from time to time. Subject to the
provisions of the Plan, the Committee shall have complete authority, in its
discretion, to make or to select the manner of making all determinations with
respect to each Award to be granted by the Company under the Plan in addition to
any other determination allowed the Committee under the Plan including, without
limitation: (a) the employee, consultant or director to receive the Award; (b)
the form of Award; (c) whether an Option (if granted to an employee) will be an
Incentive Option or a Nonstatutory Option; (d) the time of granting an Award;
(e) the number of shares subject to an Award; (f) the exercise price of an
Option or purchase price, if any, for shares of Restricted Stock or for a Stock
Grant and the method of payment of such exercise price or such purchase price;
(g) the term of an Option; (h) the vesting period of shares of Restricted Stock
or of Restricted Stock Units and any acceleration thereof; (i) the exercise date
or dates of an Option and any acceleration thereof; and (j) the effect of
termination of any employment, consulting or Board member relationship with the
Company or any of its Affiliates on the subsequent exercisability of an Option
or on the Risk of Forfeiture of Restricted Stock or Restricted Stock Units. In
making such determinations, the Committee may take into account the nature of
the services rendered by the respective employees, consultants and directors,
their present and potential contributions to the success of the Company and its
Affiliates, and such other factors as the Committee in its discretion shall deem
relevant. Subject to the provisions of the Plan, the Committee shall also have
complete authority to interpret the Plan, to prescribe, amend and rescind rules
and regulations relating to it, to determine the terms and provisions of the
respective Award Agreements (which need not be identical), and to make all other
determinations necessary or advisable for the administration of the Plan. The
Committee's determinations made in good faith on matters referred to in this
Plan shall be final, binding and conclusive on all persons having or claiming
any interest under the Plan or an Award made pursuant hereto.

6.       AUTHORIZATION AND ELIGIBILITY

         The Committee may grant from time to time and at any time prior to the
termination of the Plan one or more Awards, either alone or in combination with
any other Awards, to any employee of or consultant to one or more of the Company
and its Affiliates or to any non-employee member of the Board or of any board of
directors (or similar governing authority) of any Affiliate. However, only
employees of the Company or of any parent or subsidiary corporations of the
Company, as defined in Sections 424(e) and (f), respectively, of the Code, shall
be eligible for the grant of an Incentive Option. Further, in no event shall the
number of shares of Common Stock covered by Options or other Awards granted to
any one person in any

<PAGE>
                                      -6-

one calendar year (or portion of a year) ending after such date exceed fifty
percent (50%) of the aggregate number of shares of Common Stock subject to the
Plan.

         Each grant of an Award shall be subject to all applicable terms and
conditions of the Plan (including but not limited to any specific terms and
conditions applicable to that type of Award set out in the following Section),
and such other terms and conditions, not inconsistent with the terms of the
Plan, as the Committee may prescribe. No prospective Participant shall have any
rights with respect to an Award, unless and until such Participant has executed
an agreement evidencing the Award, delivered a fully executed copy thereof to
the Company, and otherwise complied with the applicable terms and conditions of
such Award.

7.       SPECIFIC TERMS OF AWARDS

         7.1.     Options.

                  (a) Date of Grant. The granting of an Option shall take place
at the time specified in the Award Agreement. Only if expressly so provided in
the applicable Award Agreement shall the Grant Date be the date on which the
Award Agreement shall have been duly executed and delivered by the Company and
the Optionee.

                  (b) Exercise Price. The price at which shares of Common Stock
may be acquired under each Incentive Option shall be not less than 100% of the
Market Value of Common Stock on the Grant Date, or not less than 110% of the
Market Value of Common Stock on the Grant Date if the Optionee is a Ten Percent
Owner. The price at which shares may be acquired under each Nonstatutory Option
shall not be so limited solely by reason of this Section.

                  (c) Option Period. No Incentive Option may be exercised on or
after the tenth anniversary of the Grant Date, or on or after the fifth
anniversary of the Grant Date if the Optionee is a Ten Percent Owner. The Option
period under each Nonstatutory Option shall not be so limited solely by reason
of this Section.

                  (d) Exercisability. An Option may be immediately exercisable
or become exercisable in such installments, cumulative or non-cumulative, as the
Committee may determine. In the case of an Option not otherwise immediately
exercisable in full, the Committee may Accelerate such Option in whole or in
part at any time; provided, however, that in the case of an Incentive Option,
any such Acceleration of such Incentive Option would not cause such Incentive
Option to fail to comply with the provisions of Section 422 of the Code or the
Optionee consents to such Acceleration.

                  (e) Effect of Termination of Employment, Consulting or Board
Member Relationship. Unless the Committee shall provide otherwise with respect
to any Option, if the applicable Optionee's association with the Company or any
of its Affiliates as an employee, director or consultant ends for any reason or
no reason, regardless of whether the end of such association is effected by the
Company, any such Affiliate or such Optionee (whether voluntarily or
involuntarily, including because an entity with which such Optionee has any such
association ceases to be an Affiliate of the Company), and immediately following
the end of any such association, such Optionee is not associated with the
Company or any of its Affiliates as an employee, director or consultant, or if
such Optionee dies, then any outstanding Option initially granted to such
Optionee, whether then held by such Optionee or any other Participant, shall
cease to be exercisable in any respect not later than ninety (90) days following
the end of such

<PAGE>
                                      -7-

association or such death and, for the period it remains exercisable following
the end of such association or such death, shall be exercisable only to the
extent exercisable on the date of the end of such association or such death.
Military or sick leave or other bona fide leave shall not be deemed a
termination of employment, provided that it does not exceed the longer of ninety
(90) days or the period during which the absent Optionee's reemployment rights,
if any, are guaranteed by statute or by contract.

                  (f) Transferability. Except as otherwise provided in this
subsection (f), Options shall not be transferable, and no Option or interest
therein may be sold, transferred, pledged, assigned, or otherwise alienated or
hypothecated, other than by will or by the laws of descent and distribution
(subject always to the provisions of subsection (e) above). Except as otherwise
provided in this subsection (f), all of a Participant's rights in any Option may
be exercised during the life of such Participant only by such Participant or
such Participant's legal representative. However, the applicable Award Agreement
or the Committee (at or after the grant of a Nonstatutory Option) may provide
that a Nonstatutory Option may be transferred by the applicable Participant to a
family member; provided, however, that any such transfer is without payment of
any consideration whatsoever and that no transfer of a Nonstatutory Option shall
be valid unless first approved by the Committee, acting in its sole discretion,
unless such transfer is permitted under the applicable Award Agreement. For this
purpose, "family member" means any child, stepchild, grandchild, parent,
stepparent, spouse, former spouse, sibling, niece, nephew, mother-in-law,
father-in-law, son-in-law, daughter-in-law, brother-in-law, or sister-in-law,
including adoptive relationships, any person sharing the applicable
Participant's household (other than a tenant or employee), a trust in which the
foregoing persons and/or the applicable Participant have more than fifty percent
(50%) of the beneficial interests, a foundation in which the foregoing persons
and/or the applicable Participant control the management of assets, and any
other entity in which these persons and/or the applicable Participant own more
than fifty percent (50%) of the voting interests. The Committee may at any time
or from time to time delegate to one or more officers of the Company the
authority to permit transfers of Nonstatutory Options to third parties pursuant
to this subsection (f), which authorization shall be exercised by such officer
or officers in accordance with guidelines established by the Committee at any
time and from time to time. The restrictions on transferability set forth in
this subsection (f) shall in no way preclude any Participant from effecting
"cashless" exercises of an Option pursuant to the terms of the Plan.

                  (g) Method of Exercise. An Option may be exercised by a
Participant giving written notice, in the manner provided in Section 15,
specifying the number of shares of Common Stock with respect to which the Option
is then being exercised. The notice shall be accompanied by payment in the form
of cash or check payable to the order of the Company in an amount equal to the
exercise price of the shares of Common Stock to be purchased or, subject in each
instance to the Committee's approval, acting in its sole discretion and subject
to such conditions, if any, as the Committee may deem necessary to comply with
applicable laws, rules and regulations or to avoid adverse accounting effects to
the Company, by delivery to the Company of (i) shares of Common Stock having a
Market Value equal to the exercise price of the shares to be purchased, or (ii)
the Participant's executed promissory note in the principal amount equal to the
exercise price of the shares to be purchased and otherwise in such form as the
Committee shall have approved. If the Common Stock is traded on an established
market, payment of any exercise price may also be made through and under the
terms and conditions of any formal cashless exercise program authorized by the
Company entailing the sale of the Common Stock subject to any Option in a
brokered transaction (other than to the Company). Receipt by the Company of such
notice and payment in any authorized or combination of authorized means shall
constitute the exercise of the Option. Within thirty (30) days thereafter but
subject to the remaining

<PAGE>
                                      -8-

provisions of the Plan, the Company shall deliver or cause to be delivered to
the Participant or his agent a certificate or certificates for the number of
shares then being purchased. Such shares shall be fully paid and nonassessable.
Notwithstanding any of the foregoing provisions in this subsection (g) to the
contrary, (A) no Option shall be considered to have been exercised unless and
until all of the provisions governing such exercise specified in the Plan and in
the relevant Award Agreement shall have been duly complied with; and (B) the
obligation of the Company to issue any shares upon exercise of an Option is
subject to the provisions of Section 9.1 hereof and to compliance by the
Optionee and the Participant with all of the provisions of the Plan and the
relevant Award Agreement.

                  (h) Limit on Incentive Option Characterization. An Incentive
Option shall be considered to be an Incentive Option only to the extent that the
number of shares of Common Stock for which the Option first becomes exercisable
in a calendar year do not have an aggregate Market Value (as of the date of the
grant of the Option) in excess of the "current limit". The current limit for any
Optionee for any calendar year shall be $100,000 minus the aggregate Market
Value at the date of grant of the number of shares of Common Stock available for
purchase for the first time in the same year under each other Incentive Option
previously granted to the Optionee under the Plan, and under each other
incentive stock option previously granted to the Optionee under any other
incentive stock option plan of the Company and its Affiliates, after December
31, 1986. Any shares of Common Stock which would cause the foregoing limit to be
violated shall be deemed to have been granted under a separate Nonstatutory
Option, otherwise identical in its terms to those of the Incentive Option.

                  (i) Notification of Disposition. Each person exercising any
Incentive Option granted under the Plan shall be deemed to have covenanted with
the Company to report to the Company any disposition of such shares prior to the
expiration of the holding periods specified by Section 422(a)(1) of the Code
and, if and to the extent that the realization of income in such a disposition
imposes upon the Company federal, state, local or other withholding tax
requirements, or any such withholding is required to secure for the Company an
otherwise available tax deduction, to remit to the Company an amount in cash
sufficient to satisfy those requirements.

                  (j) Rights Pending Exercise. No person holding an Option shall
be deemed for any purpose to be a stockholder of the Company with respect to any
of the shares of Common Stock issuable pursuant to such Option, except to the
extent that such Option shall have been exercised with respect thereto and, in
addition, a certificate shall have been issued therefor and delivered to such
person or his agent.

         7.2.     Restricted Stock.

                  (a) Purchase Price. Shares of Restricted Stock shall be issued
under the Plan for such consideration, in cash, other property or services, or
any combination thereof, as is determined by the Committee.

                  (b) Issuance of Certificates. Subject to subsection (c) below,
each Participant receiving an Award of Restricted Stock shall be issued a stock
certificate in respect of such shares of Restricted Stock. Such certificate
shall be registered in the name of such Participant, and, if applicable, shall
bear an appropriate legend referring to the terms, conditions, and restrictions
applicable to such Award substantially in the following form:

<PAGE>

                                      -9-

                  The transferability of this certificate and the shares
                  represented by this certificate are subject to the terms and
                  conditions of the Amicus Therapeutics, Inc. 2007 Equity
                  Incentive Plan and an Award Agreement entered into by the
                  registered owner and Amicus Therapeutics, Inc. Copies of such
                  Plan and Agreement are on file in the offices of Amicus
                  Therapeutics, Inc.

                  (c) Escrow of Shares. The Committee may require that the stock
certificates evidencing shares of Restricted Stock be held in custody by a
designated escrow agent (which may but need not be the Company) until the
restrictions thereon shall have lapsed, and that the Participant deliver a stock
power, endorsed in blank, relating to the Common Stock covered by such Award.

                  (d) Restrictions and Restriction Period. During the
Restriction Period applicable to shares of Restricted Stock, such shares shall
be subject to limitations on transferability and a Risk of Forfeiture arising on
the basis of such conditions related to the performance of services, Company or
Affiliate performance or otherwise as the Committee may determine and provide
for in the applicable Award Agreement. Any such Risk of Forfeiture may be waived
or terminated, or the Restriction Period shortened, at any time by the Committee
on such basis as it deems appropriate.

                  (e) Rights Pending Lapse of Risk of Forfeiture or Forfeiture
of Award. Except as otherwise provided in the Plan or the applicable Award
Agreement, at all times prior to lapse of any Risk of Forfeiture applicable to,
or forfeiture of, an Award of Restricted Stock, the Participant shall have all
of the rights of a stockholder of the Company, including the right to vote the
shares of Restricted Stock.

                  (f) Effect of Termination of Employment, Consulting or Board
Member Relationship. Unless otherwise determined by the Committee at or after
grant and subject to the applicable provisions of the Award Agreement, if the
applicable original grantee's association with the Company or any of its
Affiliates as an employee, director or consultant ends for any reason or no
reason during the Restriction Period, regardless of whether the end of such
association is effected by the Company, any such Affiliate or such original
grantee (whether voluntarily or involuntarily, including because an entity with
which such original grantee has any such association ceases to be an Affiliate
of the Company), and immediately following the end of any such association, such
original grantee is not associated with the Company or any of its Affiliates as
an employee, director or consultant, or if such original grantee dies, then all
outstanding shares of Restricted Stock initially granted to such original
grantee that are still subject to Risk of Forfeiture, whether then held by such
original grantee or any other Participant, shall be forfeited or otherwise
subject to return to or repurchase by the Company if and to the extent so
provided by, and subject to and in accordance with, the terms of the applicable
Award Agreement; provided, however, that military or sick leave or other bona
fide leave shall not be deemed a termination of employment, if it does not
exceed the longer of ninety (90) days or the period during which the absent
original grantee's reemployment rights, if any, are guaranteed by statute or by
contract.

                  (g) Lapse of Restrictions. If and when the Restriction Period
expires without a prior forfeiture of the Restricted Stock, the certificates for
such shares shall be delivered to the Participant promptly if not theretofore so
delivered.

<PAGE>
                                      -10-

                  (h) Transferability. Except as otherwise provided in this
subsection (h), shares of Restricted Stock shall not be transferable, and no
share of Restricted Stock or interest therein may be sold, transferred, pledged,
assigned, or otherwise alienated or hypothecated, other than by will or by the
laws of descent and distribution (subject always to the provisions of subsection
(f) above). The applicable Award Agreement or the Committee (at or after the
grant of a share of Restricted Stock) may provide that such share of Restricted
Stock may be transferred by the applicable Participant to a family member;
provided, however, that any such transfer is without payment of any
consideration whatsoever and that no transfer of a share of Restricted Stock
shall be valid unless first approved by the Committee, acting in its sole
discretion, unless such transfer is permitted under the applicable Award
Agreement. For this purpose, "family member" means any child, stepchild,
grandchild, parent, stepparent, spouse, former spouse, sibling, niece, nephew,
mother-in-law, father-in-law, son-in-law, daughter-in-law, brother-in-law, or
sister-in-law, including adoptive relationships, any person sharing the
applicable Participant's household (other than a tenant or employee), a trust in
which the foregoing persons and/or the applicable Participant have more than
fifty percent (50%) of the beneficial interests, a foundation in which the
foregoing persons and/or the applicable Participant control the management of
assets, and any other entity in which these persons and/or the applicable
Participant own more than fifty percent (50%) of the voting interests. The
Committee may at any time or from time to time delegate to one or more officers
of the Company the authority to permit transfers of shares of Restricted Stock
to third parties pursuant to this subsection (h), which authorization shall be
exercised by such officer or officers in accordance with guidelines established
by the Committee at any time and from time to time.

         7.3.     Restricted Stock Units.

                  (a) Character. Each Restricted Stock Unit shall entitle the
recipient to a share of Common Stock at a close of such Restriction Period as
the Committee may establish and subject to a Risk of Forfeiture arising on the
basis of such conditions relating to the performance of services, Company or
Affiliate performance or otherwise as the Committee may determine and provide
for in the applicable Award Agreement. Any such Risk of Forfeiture may be waived
or terminated, or the Restriction Period shortened, at any time by the Committee
on such basis as it deems appropriate.

                  (b) Issuance of Certificates. Unless otherwise determined by
the Committee at or after grant and subject to the applicable provisions of the
Award Agreement, at the close of the Restriction Period applicable to any
Restricted Stock Units (including, without limitation, the close of the
applicable Restriction Period as a result of (i) any Acceleration of Restricted
Stock Units in accordance with the terms of this Plan or any applicable Award
Agreement, (ii) any waiver, lapse or termination of the Risk of Forfeiture
applicable to Restricted Stock Units in accordance with the terms of this Plan
or any applicable Award Agreement or (iii) any shortening of the Restriction
Period applicable to any Restricted Stock Units in accordance with the terms of
this Plan or any applicable Award Agreement), the Company shall deliver or cause
to be delivered to the Participant that is the holder of such Restricted Stock
Units a stock certificate in respect of the shares of Common Stock subject to
such Restricted Stock Units. Such certificate shall be registered in the name of
such Participant, and, if applicable, shall bear an appropriate legend referring
to the terms, conditions, and restrictions applicable to such shares of Common
Stock substantially in the following form:

                  The transferability of this certificate and the shares
                  represented by this certificate are subject to the terms and
                  conditions of the

<PAGE>
                                      -11-

                  Amicus Therapeutics, Inc. 2007 Equity Incentive Plan and an
                  Award Agreement entered into by the registered owner and
                  Amicus Therapeutics, Inc. Copies of such Plan and Agreement
                  are on file in the offices of Amicus Therapeutics, Inc.

                  (c) Dividends. At the discretion of the Committee,
Participants may be entitled to receive payments equivalent to any dividends
declared with respect to Common Stock referenced in grants of Restricted Stock
Units but only following the close of the applicable Restriction Period and then
only if the underlying Common Stock shall have been earned. Unless the Committee
shall provide otherwise, any such dividend equivalents shall be paid, if at all,
without interest or other earnings.

                  (d) Effect of Termination of Employment, Consulting or Board
Member Relationship. Unless otherwise determined by the Committee at or after
grant and subject to the applicable provisions of the Award Agreement, if the
applicable original grantee's association with the Company or any of its
Affiliates as an employee, director or consultant ends for any reason or no
reason during the Restriction Period, regardless of whether the end of such
association is effected by the Company, any such Affiliate or such original
grantee (whether voluntarily or involuntarily, including because an entity with
which such original grantee has any such association ceases to be an Affiliate
of the Company), and immediately following the end of any such association, such
original grantee is not associated with the Company or any of its Affiliates as
an employee, director or consultant, or if such original grantee dies, then all
outstanding Restricted Stock Units initially granted to such original grantee
that are still subject to Risk of Forfeiture, whether then held by such original
grantee or any other Participant, shall be forfeited or otherwise subject to
return to the Company in accordance with the terms of the applicable Award
Agreement; provided, however, that military or sick leave or other bona fide
leave shall not be deemed a termination of employment, if it does not exceed the
longer of ninety (90) days or the period during which the absent original
grantee's reemployment rights, if any, are guaranteed by statute or by contract.

                  (e) Transferability. Except as otherwise provided in this
subsection (e), Restricted Stock Units shall not be transferable, and no
Restricted Stock Unit or interest therein may be sold, transferred, pledged,
assigned, or otherwise alienated or hypothecated. The applicable Award Agreement
or the Committee (at or after the grant of a Restricted Stock Unit) may provide
that such Restricted Stock Unit may be transferred by the applicable Participant
to a family member; provided, however, that any such transfer is without payment
of any consideration whatsoever and that no transfer of a Restricted Stock Unit
shall be valid unless first approved by the Committee, acting in its sole
discretion, unless such transfer is permitted under the applicable Award
Agreement. For this purpose, "family member" means any child, stepchild,
grandchild, parent, stepparent, spouse, former spouse, sibling, niece, nephew,
mother-in-law, father-in-law, son-in-law, daughter-in-law, brother-in-law, or
sister-in-law, including adoptive relationships, any person sharing the
applicable Participant's household (other than a tenant or employee), a trust in
which the foregoing persons and/or the applicable Participant have more than
fifty percent (50%) of the beneficial interests, a foundation in which the
foregoing persons and/or the applicable Participant control the management of
assets, and any other entity in which these persons and/or the applicable
Participant own more than fifty percent (50%) of the voting interests. The
Committee may at any time or from time to time delegate to one or more officers
of the Company the authority to permit transfers of Restricted Stock Units to
third parties pursuant to this subsection (e), which authorization shall be
exercised by such officer or officers in accordance with guidelines established
by the Committee at any time and from time to time.

<PAGE>
                                      -12-

                  (f) Rights Pending Close of Applicable Restriction Period. No
person holding Restricted Stock Units shall be deemed for any purpose to be a
stockholder of the Company with respect to any of the shares of Common Stock
subject to such Restricted Stock Units, except to the extent that the Restricted
Period with respect to such Restricted Stock Units shall have closed and, in
addition, a certificate shall have been issued for such shares of Common Stock
and delivered to such person or his agent. Shares of Common Stock subject to
Restricted Stock Units shall be issued and outstanding only if and to the extent
that a stock certificate representing such shares has been issued and delivered
in accordance with the provisions of this Section 7.3.

         7.4.     Stock Grants.

                  (a) In General. Stock Grants shall be issued for such
consideration, in cash, other property or services, or any combination thereof,
as is determined by the Committee. Without limiting the generality of the
foregoing, Stock Grants may be awarded in such circumstances as the Committee
deems appropriate, including without limitation in recognition of significant
contributions to the success of the Company or its Affiliates or in lieu of
compensation otherwise already due. Stock Grants shall be made without
forfeiture conditions of any kind.

                  (b) Issuance of Certificates. Each Participant receiving a
Stock Grant shall be issued a stock certificate in respect of such Stock Grant.
Such certificate shall be registered in the name of such Participant, and, if
applicable, shall bear an appropriate legend referring to the terms, conditions,
and restrictions applicable to such Award substantially in the following form:

                  The transferability of this certificate and the shares
                  represented by this certificate are subject to the terms and
                  conditions of the Amicus Therapeutics, Inc. 2007 Equity
                  Incentive Plan. A copy of such Plan is on file in the offices
                  of Amicus Therapeutics, Inc.

         7.5. Awards to Participants Outside the United States. The Committee
may modify the terms of any Award under the Plan granted to a Participant who
is, at the time of grant or during the term of the Award, resident or primarily
employed outside of the United States in any manner deemed by the Committee to
be necessary or appropriate in order that such Award shall conform to laws,
regulations, and customs of the country in which the Participant is then
resident or primarily employed, or so that the value and other benefits of the
Award to the Participant, as affected by foreign tax laws and other restrictions
applicable as a result of the Participant's residence or employment abroad,
shall be comparable to the value of such an Award to a Participant who is
resident or primarily employed in the United States. An Award may be modified
under this Section 7.4 in a manner that is inconsistent with the express terms
of the Plan, so long as such modifications will not contravene any applicable
law or regulation. The Committee may establish supplements to, or amendments,
restatements, or alternative versions of the Plan for the purpose of granting
and administrating any such modified Award. No such modification, supplement,
amendment, restatement or alternative version may increase the share limit of
Section 4.

8.       ADJUSTMENT PROVISIONS

         8.1. Adjustment for Corporate Actions. All of the share numbers set
forth in the Plan reflect the capital structure of the Company immediately after
the closing of the initial public offering of the Company's Common Stock.
Subject to the provisions of Section 8.2, if subsequent to such closing the
outstanding shares of Common Stock (or any other securities covered by the Plan
by reason of the prior application of this Section) are

<PAGE>
                                      -13-

increased, decreased, or exchanged for a different number or kind of shares or
other securities, or if additional shares or new or different shares or other
securities are distributed with respect to such shares of Common Stock or other
securities, through merger, consolidation, sale of all or substantially all the
property of the Company, reorganization, recapitalization, reclassification,
stock dividend, stock split, reverse stock split, or other distribution with
respect to such shares of Common Stock, or other securities, an appropriate and
proportionate adjustment will be made in (i) the maximum numbers and kinds of
shares provided in Section 4, (ii) the numbers and kinds of shares or other
securities subject to the then outstanding Awards, (iii) the exercise price for
each share or other unit of any other securities subject to then outstanding
Options (without change in the aggregate purchase price as to which such Options
remain exercisable), and (iv) the repurchase price of each share of Restricted
Stock then subject to a Risk of Forfeiture in the form of a Company repurchase
right.

         8.2. Change of Control. Subject to the applicable provisions of the
Award Agreement, in the event of a Change of Control, the Committee shall have
the discretion, exercisable in advance of, at the time of, or (except to the
extent otherwise provided below) at any time after, the Change of Control, to
provide for any or all of the following (subject to and upon such terms as the
Committee may deem appropriate): (A) the Acceleration, in whole or in part, of
any or all outstanding Options (including Options that are assumed or replaced
pursuant to clause (D) below) that are not exercisable in full at the time the
Change of Control, such Acceleration to become effective at the time of the
Change of Control, or at such time following the Change of Control that the
employment, consulting or Board member relationship of the applicable Optionee
or Optionees with the Company and its Affiliates terminates, or at such other
time or times as the Committee shall determine; (B) the lapse or termination of
the Risk of Forfeiture (including, without limitation, any or all of the
Company's repurchase rights) with respect to outstanding Awards of Restricted
Stock, such lapse or termination to become effective at the time of the Change
of Control, or at such time following the Change of Control that the employment,
consulting or Board member relationship with the Company and its Affiliates of
the Participant or Participants that hold such Awards of Restricted Stock (or
the person to whom such Awards of Restricted Stock were initially granted)
terminates, or at such other time or times as the Committee shall determine; (C)
the lapse or termination of the Risk of Forfeiture with respect to any or all
outstanding Awards of Restricted Stock Units (including Restricted Stock Units
that are assumed or replaced pursuant to clause (D) below), such lapse or
termination to become effective at the time of the Change of Control, or at such
time following the Change of Control that the employment, consulting or Board
member relationship with the Company and its Affiliates of the Participant or
Participants that hold such Awards of Restricted Stock Units (or the person to
whom such Awards of Restricted Stock Units were initially granted) terminates,
or at such other time or times as the Committee shall determine; (D) the
assumption of outstanding Options or Restricted Stock Units, or the substitution
of outstanding Options or Restricted Stock Units with equivalent options or
equivalent restricted stock units, as the case may be, by the acquiring or
succeeding corporation or entity (or an affiliate thereof); (E) the termination
of all Options (other than Options that are assumed or substituted pursuant to
clause (D) above) that remain outstanding at the time of the consummation of the
Change of Control, provided that, the Committee shall have made the
determination to effect such termination prior to the consummation of the Change
of Control and the Committee shall have given, or caused to be given, to all
Participants written notice of such potential termination at least five business
days prior to the consummation of the Change of Control, and provided, further,
that, if the Committee shall have determined in its sole and absolute discretion
that the Corporation make payment or provide consideration to the holders of
such terminated Options on account of such termination, which payment or
consideration shall be on such terms and conditions as the Committee shall

<PAGE>
                                      -14-

have determined (and which could consist of, in the Committee's sole and
absolute discretion, payment to the applicable Optionee or Optionees of an
amount of cash equal to the difference between the Market Value of the shares of
Common Stock for which the Option is then exercisable and the aggregate exercise
price for such shares under the Option), then the Corporation shall be required
to make, or cause to be made, such payment or provide, or cause to be provided,
such consideration in accordance with the terms and conditions so determined by
the Committee, otherwise the Corporation shall not be required to make any
payment or provide any consideration in connection with, or as a result of, the
termination of Options pursuant to the foregoing provisions of this clause (E);
or (F) the termination of all Restricted Stock Units (other than Restricted
Stock Units that are assumed or substituted pursuant to clause (D) above) that
remain outstanding at the time of the consummation of the Change of Control,
provided that, if the Committee shall have determined in its sole and absolute
discretion that the Corporation make payment or provide consideration to the
holders of such terminated Restricted Stock Units on account of such
termination, which payment or consideration shall be on such terms and
conditions as the Committee shall have determined (and which could consist of,
in the Committee's sole and absolute discretion, payment to the applicable
Participant or Participants of an amount of cash equal to the Market Value of
the shares of Common Stock subject to the terminated Restricted Stock Units),
then the Corporation shall be required to make such payment or provide such
consideration in accordance with the terms and conditions so determined by the
Committee, otherwise the Corporation shall not be required to make any payment
or provide any consideration in connection with, or as a result of, the
termination of Restricted Stock Units pursuant to the foregoing provisions of
this clause (F). The provisions of this Section 8.2 shall not be construed as to
limit or restrict in any way the Committee's general authority under Sections
7.1(d) or 7.2(d) hereof to Accelerate Options in whole or in part at any time or
to waive or terminate at any time any Risk of Forfeiture applicable to shares of
Restricted Stock or Restricted Stock Units. Each outstanding Option or
Restricted Stock Unit that is assumed in connection with a Change of Control, or
is otherwise to continue in effect subsequent to a Change of Control, will be
appropriately adjusted, immediately after the Change of Control, as to the
number and class of securities and the price at which it may be exercised in
accordance with Section 8.1.

         8.3. Dissolution or Liquidation. Upon dissolution or liquidation of the
Company, each outstanding Option shall terminate, but the Optionee (if at the
time he or she has an employment, consulting or Board member relationship with
the Company or any of its Affiliates) shall have the right, immediately prior to
such dissolution or liquidation, to exercise the Option to the extent
exercisable on the date of such dissolution or liquidation.

         8.4. Related Matters. Any adjustment in Awards made pursuant to this
Section 8 shall be determined and made, if at all, by the Committee and shall
include any correlative modification of terms, including of Option exercise
prices, rates of vesting or exercisability, Risks of Forfeiture and applicable
repurchase prices for Restricted Stock, which the Committee may deem necessary
or appropriate so as to ensure that the rights of the Participants in their
respective Awards are not substantially diminished nor enlarged as a result of
the adjustment and corporate action other than as expressly contemplated in this
Section 8. No fraction of a share shall be purchasable or deliverable upon
exercise, but in the event any adjustment hereunder of the number of shares
covered by an Award shall cause such number to include a fraction of a share,
such number of shares shall be adjusted to the nearest smaller whole number of
shares. No adjustment of an Option exercise price per share pursuant to this
Section 8 shall result in an exercise price which is less than the par value of
the Common Stock.

9.       SETTLEMENT OF AWARDS

<PAGE>
                                      -15-

         9.1. Violation of Law. Notwithstanding any other provision of the Plan
or the relevant Award Agreement, if, at any time, in the reasonable opinion of
the Company, the issuance of shares of Common Stock covered by an Award may
constitute a violation of law, then the Company may delay such issuance and the
delivery of a certificate for such shares until (i) approval shall have been
obtained from such governmental agencies, other than the Securities and Exchange
Commission, as may be required under any applicable law, rule, or regulation and
(ii) in the case where such issuance would constitute a violation of a law
administered by or a regulation of the Securities and Exchange Commission, one
of the following conditions shall have been satisfied:

                  (a) the shares are at the time of the issue of such shares
effectively registered under the Securities Act; or

                  (b) the Company shall have determined, on such basis as it
deems appropriate (including an opinion of counsel in form and substance
satisfactory to the Company) that the sale, transfer, assignment, pledge,
encumbrance or other disposition of such shares or such beneficial interest, as
the case may be, does not require registration under the Securities Act or any
applicable state securities laws.

         9.2. Corporate Restrictions on Rights in Stock. Any Common Stock to be
issued pursuant to Awards granted under the Plan shall be subject to all
restrictions upon the transfer thereof which may be now or hereafter imposed by
the Certificate of Incorporation and the By-laws of the Company, each as amended
and in effect from time to time. Whenever Common Stock is to be issued pursuant
to an Award, if the Committee so directs at the time of grant (or, if such Award
is an Option, at any time prior to the exercise thereof), the Company shall be
under no obligation, notwithstanding any other provision of the Plan or the
relevant Award Agreement to the contrary, to issue such shares until such time,
if ever, as the recipient of the Award (and any person who exercises any Option,
in whole or in part), shall have become a party to and bound by any agreement
that the Committee shall require in its sole discretion. In addition, any Common
Stock to be issued pursuant to Awards granted under the Plan shall be subject to
all stop-transfer orders and other restrictions as the Committee may deem
advisable under the rules, regulations and other requirements of any stock
exchange upon which the Common Stock is then listed, and any applicable federal
or state securities laws, and the Committee may cause a legend or legends to be
put on any such certificates to make appropriate reference to such restrictions.

         9.3. Investment Representations. The Company shall be under no
obligation to issue any shares covered by an Award unless the shares to be
issued pursuant to Awards granted under the Plan have been effectively
registered under the Securities Act or the Participant shall have made such
written representations to the Company (upon which the Company believes it may
reasonably rely) as the Company may deem necessary or appropriate for purposes
of confirming that the issuance of such shares will be exempt from the
registration requirements of that Act and any applicable state securities laws
and otherwise in compliance with all applicable laws, rules and regulations,
including but not limited to that the Participant is acquiring shares for his or
her own account for the purpose of investment and not with a view to, or for
sale in connection with, the distribution of any such shares.

         9.4. Registration. If the Company shall deem it necessary or desirable
to register under the Securities Act or other applicable statutes any shares of
Common Stock issued or to be issued pursuant to Awards granted under the Plan,
or to qualify any such shares of Common Stock for exemption from the Securities
Act or other applicable statutes, then the Company shall

<PAGE>
                                      -16-

take such action at its own expense. The Company may require from each recipient
of an Award, or each holder of shares of Common Stock acquired pursuant to the
Plan, such information in writing for use in any registration statement,
prospectus, preliminary prospectus or offering circular as is reasonably
necessary for such purpose and may require reasonable indemnity to the Company
and its officers and directors from such holder against all losses, claims,
damage and liabilities arising from such use of the information so furnished and
caused by any untrue statement of any material fact therein or caused by the
omission to state a material fact required to be stated therein or necessary to
make the statements therein not misleading in the light of the circumstances
under which they were made.

         9.5. Lock-Up. Without the prior written consent of the Company or the
managing underwriter in any public offering of shares of Common Stock, no
Participant shall sell, make any short sale of, loan, grant any option for the
purchase of, pledge or otherwise encumber, or otherwise dispose of, any shares
of Common Stock during the one hundred-eighty (180) day period commencing on the
effective date of the registration statement relating to any underwritten public
offering of securities of the Company. The foregoing restrictions are intended
and shall be construed so as to preclude any Participant from engaging in any
hedging or other transaction that is designed to or reasonably could be expected
to lead to or result in, a sale or disposition of any shares of Common Stock
during such period even if such shares of Common Stock are or would be disposed
of by someone other than such Participant. Such prohibited hedging or other
transactions would include, without limitation, any short sale (whether or not
against the box) or any purchase, sale or grant of any right (including without
limitation any put or call option) with respect to any shares of Common Stock or
with respect to any security that includes, relates to, or derives any
significant part of its value from any shares of Common Stock. Without limiting
the generality of the foregoing provisions of this Section 9.5, if, in
connection with any underwritten public offering of securities of the Company,
the managing underwriter of such offering requires that the Company's directors
and officers enter into a lock-up agreement containing provisions that are more
restrictive than the provisions set forth in the preceding sentence, then (a)
each Participant (regardless of whether or not such Participant has complied or
complies with the provisions of clause (b) below) shall be bound by, and shall
be deemed to have agreed to, the same lock-up terms as those to which the
Company's directors and officers are required to adhere; and (b) at the request
of the Company or such managing underwriter, each Participant shall execute and
deliver a lock-up agreement in form and substance equivalent to that which is
required to be executed by the Company's directors and officers.

         9.6. Placement of Legends; Stop Orders; Etc. Each share of Common Stock
to be issued pursuant to Awards granted under the Plan may bear a reference to
the investment representations made in accordance with Section 9.3 in addition
to any other applicable restrictions under the Plan, the terms of the Award and,
if applicable, under any agreement between the Company and any Optionee and/or
Participant, and to the fact that no registration statement has been filed with
the Securities and Exchange Commission in respect to such shares of Common
Stock. All certificates for shares of Common Stock or other securities delivered
under the Plan shall be subject to such stock transfer orders and other
restrictions as the Committee may deem advisable under the rules, regulations,
and other requirements of any stock exchange upon which the Common Stock is then
listed, and any applicable federal or state securities law, and the Committee
may cause a legend or legends to be placed on any such certificates to make
appropriate reference to such restrictions.

         9.7. Tax Withholding. Whenever shares of Common Stock are issued or to
be issued pursuant to Awards granted under the Plan, the Company shall have the
right to require the

<PAGE>
                                      -17-

recipient to remit to the Company an amount sufficient to satisfy federal,
state, local or other withholding tax requirements if, when, and to the extent
required by law (whether so required to secure for the Company an otherwise
available tax deduction or otherwise) prior to the delivery of any certificate
or certificates for such shares. The obligations of the Company under the Plan
shall be conditional on satisfaction of all such withholding obligations and the
Company shall, to the extent permitted by law, have the right to deduct any such
taxes from any payment of any kind otherwise due to the recipient of an Award.
However, in such cases Participants may elect, subject to the approval of the
Committee, acting in its sole discretion, to satisfy an applicable withholding
requirement, in whole or in part, by having the Company withhold shares to
satisfy their tax obligations. Participants may only elect to have shares of
their Common Stock withheld having a Market Value on the date the tax is to be
determined equal to the minimum statutory total tax which could be imposed on
the transaction. All elections shall be irrevocable, made in writing, signed by
the Participant, and shall be subject to any restrictions or limitations that
the Committee deems appropriate.

10.      RESERVATION OF STOCK

         The Company shall at all times during the term of the Plan and any
outstanding Options granted hereunder reserve or otherwise keep available such
number of shares of Common Stock as will be sufficient to satisfy the
requirements of the Plan (if then in effect) and such Options and shall pay all
fees and expenses necessarily incurred by the Company in connection therewith.

11.      NO SPECIAL SERVICE RIGHTS

         Nothing contained in the Plan or in any Award Agreement shall confer
upon any recipient of an Award any right with respect to the continuation of his
or her employment, consulting or Board member relationship or other association
with the Company (or any Affiliate), or interfere in any way with the right of
the Company (or any Affiliate), subject to the terms of any separate employment,
consulting or Board member agreement or provision of law or corporate articles
or by-laws to the contrary, at any time to terminate such employment, consulting
or Board member agreement or to increase or decrease, or otherwise adjust, the
other terms and conditions of the recipient's employment, consulting or Board
member relationship or other association with the Company and its Affiliates.

12.      NONEXCLUSIVITY OF THE PLAN

         Neither the adoption of the Plan by the Board nor the submission of the
Plan to the stockholders of the Company shall be construed as creating any
limitations on the power of the Board to adopt such other incentive arrangements
as it may deem desirable, including without limitation, the granting of stock
options, restricted stock and restricted stock units other than under the Plan,
and such arrangements may be either applicable generally or only in specific
cases.

13.      TERMINATION AND AMENDMENT OF THE PLAN

         The Board may at any time terminate the Plan or make such amendments or
modifications of the Plan as it shall deem advisable. In the event of the
termination of the Plan, the terms of the Plan shall survive any such
termination with respect to any Award that is outstanding on the date of such
termination, unless the holder of such Award agrees in writing to terminate such
Award or to terminate all or any of the provisions of the Plan that apply to
such
<PAGE>
                                      -18-

Award. Unless the Board otherwise expressly provides, any amendment or
modification of the Plan shall affect the terms of any Award outstanding on the
date of such amendment or modification as well as the terms of any Award made
from and after the date of such amendment or modification; provided, however,
that, except to the extent otherwise provided in the last sentence of this
paragraph, (i) no amendment or modification of the Plan shall apply to any Award
that is outstanding on the date of such amendment or modification if such
amendment or modification would reduce the number of shares subject to such
Award, increase the purchase price applicable to shares subject to such Award or
materially adversely affect the provisions applicable to such Award that relate
to the vesting or exercisability of such Award or of the shares subject to such
Award, (ii) no amendment or modification of the Plan shall apply to any
Incentive Option that is outstanding on the date of such amendment or
modification if such amendment or modification would result in such Incentive
Option no longer being treated as an "incentive stock option" within the meaning
of Section 422 of the Code and (iii) no amendment or modification of the Plan
shall apply to any Award that is outstanding on the date of such amendment or
modification unless such amendment or modification of the Plan shall also apply
to all other Awards outstanding on the date of such amendment or modification.
In the event of any amendment or modification of the Plan that is described in
clause (i), (ii) or (iii) of the foregoing proviso, such amendment or
modification of the Plan shall apply to any Award outstanding on the date of
such amendment or modification only if the recipient of such Award consents in
writing thereto.

         The Committee may amend or modify, prospectively or retroactively, the
terms of any outstanding Award without amending or modifying the terms of the
Plan itself, provided that as amended or modified such Award is consistent with
the terms of the Plan as in effect at the time of the amendment or modification
of such Award, but no such amendment or modification of such Award shall,
without the written consent of the recipient of such Award, reduce the number of
shares subject to such Award, increase the purchase price applicable to shares
subject to such Award, adversely affect the provisions applicable to such Award
that relate to the vesting or exercisability of such Award or of the shares
subject to such Award, or otherwise materially adversely affect the terms of
such Award (except for amendments or modifications to the terms of such Award or
of the stock subject to such Award that are expressly permitted by the terms of
the Plan or that result from any amendment or modification of the Plan in
accordance with the provisions of the first paragraph of this Section 13), or,
if such Award is an Incentive Option, result in such Incentive Option no longer
being treated as an "incentive stock option" within the meaning of Section 422
of the Code. Notwithstanding any of the foregoing provisions of this paragraph
to the contrary, the Committee is expressly authorized to amend any or all
outstanding Options to effect a repricing thereof by lowering the purchase price
applicable to the shares of Common Stock subject to such Option or Options
without the approval of the stockholders of the Company or the holder or holders
of such Option or Options, and, in connection with such repricing, to amend or
modify any of the other terms of the Option or Options so repriced, including,
without limitation, for purposes of reducing the number of shares subject to
such Option or Options or for purposes of adversely affecting the provisions
applicable to such Option or Options that relate to the vesting or
exercisability thereof, in each case without the approval of stockholders of the
Company or the holder or holders of such Option or Options.

         In addition, notwithstanding anything express or implied in any of the
foregoing provisions of this Section 13 to the contrary, the Committee may amend
or modify, prospectively or retroactively, the terms of any outstanding Award to
the extent the Committee reasonably determines necessary or appropriate to
conform such Award to the requirements of Section 409A of the Code (concerning
non-qualified deferred compensation), if applicable.

<PAGE>
                                      -19-

14.      INTERPRETATION OF THE PLAN

         In the event of any conflict between the provisions of this Plan and
the provisions of any applicable Award Agreement, the provisions of this Plan
shall control, except if and to the extent that the conflicting provision in
such Award Agreement was authorized and approved by the Committee at the time of
the grant of the Award evidenced by such Award Agreement or is ratified by the
Committee at any time subsequent to the grant of such Award, in which case the
conflicting provision in such Award Agreement shall control. Without limiting
the generality of the foregoing provisions of this Section 14, insofar as
possible the provisions of the Plan and such Award Agreement shall be construed
so as to give full force and effect to all such provisions. In the event of any
conflict between the provisions of this Plan and the provisions of any other
agreement between the Company and the Optionee and/or Participant, the
provisions of such agreement shall control except as required to fulfill the
intention that this Plan constitute an incentive stock option plan within the
meaning of Section 422 of the Code, but insofar as possible the provisions of
the Plan and any such agreement shall be construed so as to give full force and
effect to all such provisions.

15.      NOTICES AND OTHER COMMUNICATIONS

         Any notice, demand, request or other communication hereunder to any
party shall be deemed to be sufficient if contained in a written instrument
delivered in person or duly sent by first class registered, certified or
overnight mail, postage prepaid, or telecopied with a confirmation copy by
regular, certified or overnight mail, addressed or telecopied, as the case may
be, (i) if to the recipient of an Award, at his or her residence address last
filed with the Company and (ii) if to the Company, at its principal place of
business, addressed to the attention of its Chief Executive Officer, or to such
other address or telecopier number, as the case may be, as the addressee may
have designated by notice to the addressor. All such notices, requests, demands
and other communications shall be deemed to have been received: (i) in the case
of personal delivery, on the date of such delivery; (ii) in the case of mailing,
when received by the addressee; and (iii) in the case of facsimile transmission,
when confirmed by facsimile machine report.

16.      GOVERNING LAW

         The Plan and all Award Agreements and actions taken thereunder shall be
governed, interpreted and enforced in accordance with the laws of the State of
New Jersey, without regard to the conflict of laws principles thereof.

<PAGE>
                            AMICUS THERAPEUTICS, INC.

                      NON-STATUTORY STOCK OPTION AGREEMENT
                 (Form of Non-Statutory Stock Option Agreement)

      This NON-STATUTORY STOCK OPTION AGREEMENT, dated as of <date> (this
"Agreement"), is between AMICUS THERAPEUTICS, INC., a Delaware corporation (the
"Company"), and <Optionee Name> (the "Optionee"). Capitalized terms used herein
without definition shall have the meaning ascribed to such terms in the
Company's 2007 Equity Incentive Plan, a copy of which is attached hereto as
Exhibit A (the "Plan").

      1. Grant of Option. Pursuant to the Plan, the Company grants to the
Optionee an option (the "Option") to purchase from the Company all or any number
of an aggregate of <Number of Shares> shares, subject to adjustment pursuant to
Section 8 of the Plan (the "Option Shares"), of the Company's common stock, $.01
par value per share, at a price of $<price> per share. The Option is granted as
of <Date of Grant> (the "Grant Date").

      2. Character of Option. The Option is not intended to be treated as an
"incentive stock option" within the meaning of Section 422 of the Internal
Revenue Code of 1986, as amended.

      3. Duration of Option. Unless subject to earlier expiration or termination
pursuant to the terms of the Plan or pursuant to Section 5 below, the Option
shall expire on the ten year anniversary of the Grant Date.

       4. Exercisability of Option. The Option may be exercised, at any time and
from time to time until its expiration or termination, for any or all of those
Option Shares in respect of which the Option shall have become exercisable, in
accordance with the provisions set forth below in this Section 4 and in the
manner provided for in the Plan Subject to the provisions of the Plan
(including, without limitation, the provisions of Section 7.1(e) and Section 8
of the Plan), and subject to the provisions of Section 5 below, the Option shall
become exercisable (i) for [______] Option Shares on [_______] (the "First
Vesting Date"), (ii) for [_______] Option Shares on the first day of each of
the next [_____] calendar months, beginning on the calendar month next following
the First Vesting Date., and (iii) for [______] Option Shares on [_______].(1)
Notwithstanding anything expressed or implied to the contrary in the foregoing
provisions of this Section 4, the exercisability of the Option may, as provided
in Section 7.1(d) of the Plan, at any time be Accelerated in the discretion of
the Committee.

      5. Effect of Termination of Employment, Consulting or Board Member
Relationship. Subject to Section 7.1(e) of the Plan, if the Optionee's
association with the Company as an employee, director or consultant ends,
regardless of how the end of such association is effected, and immediately
following the end of any such association such Optionee is not associated with
the Company as an employee, director or consultant, or if such Optionee dies,
then the Option shall cease to be exercisable in any respect not later than
ninety (90) days

--------
1    The specific vesting schedule of each Option granted under the Plan is
     determined at the discretion of the Committee on a case-by-case basis at
     the time of grant.

<PAGE>
                                      -2-

following the end of such association or such death and, for the period it
remains exercisable following the end of such association or such death, shall
be exercisable only to the extent exercisable on the date of the end of such
association or such death (after giving effect to any Acceleration that may be
applicable to the Option).

      6. Transfer of Option. Other than as expressly permitted by the provisions
of Section 7.1(f) of the Plan, the Option may not be transferred except by will
or the laws of descent and distribution and, during the lifetime of the
Optionee, may be exercised only by the Optionee.

      7. Incorporation of Plan Terms. The Option is granted subject to all of
the applicable terms and provisions of the Plan, including, but not limited to,
the limitations on the Company's obligation to deliver Option Shares upon
exercise set forth in Section 9.1 (Violation of Law), Section 9.2 (Corporate
Restrictions on Rights in Stock), Section 9.3 (Investment Representations) and
Section 9.7 (Tax Withholding).

      8. Miscellaneous. This Agreement shall be construed and enforced in
accordance with the internal, substantive laws of the State of New Jersey, and
shall be binding upon and inure to the benefit of any successor or assign of the
Company and any executor, administrator, trustee, guardian, or other legal
representative of the Optionee.

            [The remainder of this page is intentionally left blank.]

<PAGE>
                                      -3-

      IN WITNESS WHEREOF, the parties have executed this Non-Statutory Stock
Option Agreement as a sealed instrument as of the date first above written.

AMICUS THERAPEUTICS, INC.                          OPTIONEE

By:   ___________________________                  _____________________________
      Name:
      Title

                                                   Optionee's Address:

                                                   _____________________________

                                                   _____________________________

                                                   _____________________________

                                                   _____________________________

<PAGE>
                                                                       Exhibit A

                           2007 EQUITY INCENTIVE PLAN

<PAGE>
                            AMICUS THERAPEUTICS, INC.

                        INCENTIVE STOCK OPTION AGREEMENT
             (Form of Incentive Stock Option Agreement - Executive)

      This INCENTIVE STOCK OPTION AGREEMENT, dated as of <date> (this
"Agreement"), is between AMICUS THERAPEUTICS, INC., a Delaware corporation (the
"Company"), and <Executive Name> (the "Optionee"). Capitalized terms used herein
without definition shall have the meaning ascribed to such terms in the
Company's 2007 Equity Incentive Plan, a copy of which is attached hereto as
Exhibit A (the "Plan").

      1. Grant of Option. Pursuant to the Plan, the Company grants to the
Optionee an option (the "Option") to purchase from the Company all or any number
of an aggregate of <Number of Shares> shares, subject to adjustment pursuant to
Section 8 of the Plan (the "Option Shares"), of the Company's common stock, $.01
par value per share, at a price of $<price> per share. The Option is granted as
of <Date of Grant> (the "Grant Date").

      2. Character of Option. The Option is intended to be treated as an
"incentive stock option" within the meaning of Section 422 of the Internal
Revenue Code of 1986, as amended.

      3. Duration of Option. Unless subject to earlier expiration or termination
pursuant to the terms of the Plan or pursuant to Section 5 below, the Option
shall expire on the ten year anniversary of the Grant Date.

      4. Exercisability of Option. The Option may be exercised, at any time and
from time to time until its expiration or termination, for any or all of those
Option Shares in respect of which the Option shall have become exercisable, in
accordance with the provisions set forth below in this Section 4 and in the
manner provided for in the Plan. Subject to the provisions of the Plan
(including, without limitation, the provisions of Section 7.1(e) and Section 8
of the Plan), and subject to the provisions of Section 5 below, the Option shall
become exercisable (i) for [______] Option Shares on [_______] (the "First
Vesting Date"), (ii) for [_______] Option Shares on the first day of each of the
next [_____] calendar months, beginning on the calendar month next following the
First Vesting Date, and (iii) for [______] Option Shares on [_______].(1)
Notwithstanding anything expressed or implied to the contrary in the foregoing
provisions of this Section 4, the exercisability of the Option (i) may, as
provided in Section 7.1(d) of the Plan, at any time be Accelerated in the
discretion of the Committee, and (ii) may be subject to Acceleration if, to the
extent, and under the circumstances, provided in the Optionee's [employment
offer letter / employment agreement], dated [______], or in any written
agreement between the Optionee and the Company.

      5. Effect of Termination of Employment Relationship. Subject to Section
7.1(e) of the Plan, if the Optionee's employment with the Company ends,
regardless of how the end of such employment is effected, or if such Optionee
dies, then the Option shall cease to be exercisable in any respect not later
than ninety (90) days following the end of such employment or such death and,
for the period it remains exercisable following the end of such employment or

--------
1    The specific vesting schedule of each Option granted under the Plan is
     determined at the discretion of the Committee on a case-by-case basis at
     the time of grant.
<PAGE>
                                      -2-

such death, shall be exercisable only to the extent exercisable on the date of
the end of such employment or such death (after giving effect to any
Acceleration that may be applicable to the Option).

      6. Transfer of Option. Other than as expressly permitted by the provisions
of Section 7.1(f) of the Plan, the Option may not be transferred except by will
or the laws of descent and distribution and, during the lifetime of the
Optionee, may be exercised only by the Optionee.

      7. Incorporation of Plan Terms. The Option is granted subject to all of
the applicable terms and provisions of the Plan, including, but not limited to,
the limitations on the Company's obligation to deliver Option Shares upon
exercise set forth in Section 9.1 (Violation of Law), Section 9.2 (Corporate
Restrictions on Rights in Stock), Section 9.3 (Investment Representations) and
Section 9.7 (Tax Withholding).

      8. Miscellaneous. This Agreement shall be construed and enforced in
accordance with the internal, substantive laws of the State of New Jersey, and
shall be binding upon and inure to the benefit of any successor or assign of the
Company and any executor, administrator, trustee, guardian, or other legal
representative of the Optionee.

            [The remainder of this page is intentionally left blank.]

<PAGE>
                                      -3-

      IN WITNESS WHEREOF, the parties have executed this Incentive Stock Option
Agreement as a sealed instrument as of the date first above written.

AMICUS THERAPEUTICS, INC.                          OPTIONEE

By:   ___________________________                  _____________________________
      Name:
      Title

                                                   Optionee's Address:

                                                   _____________________________

                                                   _____________________________

                                                   _____________________________

                                                   _____________________________
<PAGE>
                                                                       Exhibit A

                           2007 EQUITY INCENTIVE PLAN

<PAGE>
                            AMICUS THERAPEUTICS, INC.

                        INCENTIVE STOCK OPTION AGREEMENT
              (Form of Incentive Stock Option Agreement - Employee)

      This INCENTIVE STOCK OPTION AGREEMENT, dated as of <date> (this
"Agreement"), is between AMICUS THERAPEUTICS, INC., a Delaware corporation (the
"Company"), and <Employee Name> (the "Optionee"). Capitalized terms used herein
without definition shall have the meaning ascribed to such terms in the
Company's 2007 Equity Incentive Plan, a copy of which is attached hereto as
Exhibit A (the "Plan").

      1. Grant of Option. Pursuant to the Plan, the Company grants to the
Optionee an option (the "Option") to purchase from the Company all or any number
of an aggregate of <Number of Shares> shares, subject to adjustment pursuant to
Section 8 of the Plan (the "Option Shares"), of the Company's common stock, $.01
par value per share, at a price of $<price> per share. The Option is granted as
of <Date of Grant> (the "Grant Date").

      2. Character of Option. The Option is intended to be treated as an
"incentive stock option" within the meaning of Section 422 of the Internal
Revenue Code of 1986, as amended.

      3. Duration of Option. Unless subject to earlier expiration or termination
pursuant to the terms of the Plan or pursuant to Section 5 below, the Option
shall expire on the ten year anniversary of the Grant Date.

      4. Exercisability of Option. The Option may be exercised, at any time and
from time to time until its expiration or termination, for any or all of those
Option Shares in respect of which the Option shall have become exercisable, in
accordance with the provisions set forth below in this Section 4 and in the
manner provided for in the Plan. Subject to the provisions of the Plan
(including, without limitation, the provisions of Section 7.1(e) and Section 8
of the Plan), and subject to Section 5 below, the Option shall become
exercisable (i) for [______] Option Shares on [_______] (the "First Vesting
Date"), (ii) for [_______] Option Shares on the first day of each of the next
[_____] calendar months, beginning on the calendar month next following the
First Vesting Date, and (iii) for [______] Option Shares on [_______].(1)
Notwithstanding anything expressed or implied to the contrary in the foregoing
provisions of this Section 4, the exercisability of the Option may, as provided
in Section 7.1(d) of the Plan, at any time be Accelerated in the discretion of
the Committee.

      5. Effect of Termination of Employment Relationship. Subject to Section
7.1(e) of the Plan, if the Optionee's employment with the Company ends,
regardless of how the end of such employment is effected, or if such Optionee
dies, then the Option shall cease to be exercisable in any respect not later
than ninety (90) days following the end of such employment or such death and,
for the period it remains exercisable following the end of such employment or
such death, shall be exercisable only to the extent exercisable on the date of
the end of such employment or such death (after giving effect to any
Acceleration that may be applicable to the Option).

--------
1    The specific vesting schedule of each Option granted under the Plan is
     determined at the discretion of the Committee on a case-by-case basis at
     the time of grant.

<PAGE>
                                      -2-

      6. Transfer of Option. Other than as expressly permitted by the provisions
of Section 7.1(f) of the Plan, the Option may not be transferred except by will
or the laws of descent and distribution and, during the lifetime of the
Optionee, may be exercised only by the Optionee.

      7. Incorporation of Plan Terms. The Option is granted subject to all of
the applicable terms and provisions of the Plan, including, but not limited to,
the limitations on the Company's obligation to deliver Option Shares upon
exercise set forth in Section 9.1 (Violation of Law), Section 9.2 (Corporate
Restrictions on Rights in Stock), Section 9.3 (Investment Representations) and
Section 9.7 (Tax Withholding).

      8. Miscellaneous. This Agreement shall be construed and enforced in
accordance with the internal, substantive laws of the State of New Jersey, and
shall be binding upon and inure to the benefit of any successor or assign of the
Company and any executor, administrator, trustee, guardian, or other legal
representative of the Optionee.

            [The remainder of this page is intentionally left blank.]

<PAGE>
                                      -3-

      IN WITNESS WHEREOF, the parties have executed this Incentive Stock Option
Agreement as a sealed instrument as of the date first above written.

AMICUS THERAPEUTICS, INC.                          OPTIONEE

By:   ___________________________                  _____________________________
      Name:
      Title

                                                   Optionee's Address:

                                                   _____________________________

                                                   _____________________________

                                                   _____________________________

                                                   _____________________________

<PAGE>

                                                                       Exhibit A

                           2007 EQUITY INCENTIVE PLAN

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