Document:

Employment Agreement

 Exhibit 10.1 
 EMPLOYMENT AGREEMENT 
 THIS EMPLOYMENT AGREEMENT (the “Agreement”), made this 12th
day of October, 2006 (the “Effective Date”), is entered into among Ross Simmonds (“Executive”), Alphatec Spine, Inc., a California corporation (the “ASI”), and Alphatec Holdings, Inc., a Delaware corporation
(“Parent”) (collectively, ASI and Parent shall be referred to as the “Company”). 
 1. Commencement. This
Agreement, which shall govern Executive’s employment by the Company, shall become effective on the Effective Date and the Executive’s employment shall begin on October 23, 2006 (the “Commencement Date”). 
 2. At-will Employment. The parties to this Agreement agree and acknowledge that the Executive’s employment pursuant to this Agreement shall
be considered at will. Either party may terminate this Agreement at any time, with or without Cause (as defined below) pursuant to the terms of this Agreement. 
 3. Title; Capacity; Office. The Company shall employ Executive, and Executive agrees to work for the Company, as its Senior Vice President, Sales and Marketing. Executive shall perform the duties and
responsibilities inherent in the position in which Executive serves and such other duties and responsibilities as the President and Chief Executive Officer (or his or her designee(s)) shall from time to time reasonably assign to Executive. Executive
shall report to the President and Chief Executive Officer (or his or her designee(s)). 
 4. Compensation and Benefits. While employed
by the Company, Executive shall be entitled to the following (it being agreed, for the avoidance of doubt, that, except as provided in Section 6.2, amounts payable on the happening of any specified event will not be payable if the Executive is
not employed by the Company upon the happening of such event): 
 4.1 Salary. Commencing on the Commencement Date, the Company shall
pay Executive an annual base salary of $315,000.00, less applicable payroll withholdings, payable in accordance with the Company’s customary payroll practices, with salary increases, if any, to be determined by the Board on an annual basis in
January of each subsequent year of Executive’s employment. 
 4.2 Performance Bonus. Executive will be eligible to receive a cash
performance bonus each fiscal year in an amount equal to 50% of the annual base salary for such fiscal year (the “Total Bonus Amount”) based on Executive’s achievement of quarterly and annual performance objectives established by the
Board or their designee(s) at the beginning of each fiscal year. Up to twelve and a half percent (12.5%) of the Total Bonus Amount shall be payable within 30 days of the end of each fiscal quarter (for a total of up to 50% of the Total Bonus
Amount), based on Executive’s achievement of quarterly objectives, and up to fifty percent (50%) of the Total Bonus Amount shall be payable within 30 days after the end of the fiscal year, based on Executive’s achievement of annual
objectives. For fiscal year 2006, the Total Bonus Amount shall be based on the achievement of objectives established by the board of directors of the Company or their designee(s) (collectively, the “Board”) for such year. 

 4.3 Fringe Benefits. Executive shall be entitled to participate in all benefit programs that the
Company establishes and makes available to its management employees. Executive will also be entitled to take fully paid vacation in accordance with Company policy, which shall be not less than three (3) weeks per calendar year, with no
forfeiture for unused vacation days. Each calendar year during the Term, the Company agrees to reimburse the Executive in an amount not to exceed $4,500 (with such amount increased each year at a rate equal to the consumer price index) for the
annual premium associated with Executive’s purchase of a disability insurance policy covering the Executive. 
 4.4 Reimbursement of
Expenses. Executive shall be entitled to prompt reimbursement for reasonable expenses incurred or paid by Executive in connection with, or related to the performance of, Executive’s duties, responsibilities or services under this Agreement,
upon presentation by Executive of documentation, expense statements, vouchers and/or such other supporting information as the Company may reasonably request. 
 4.5 Equity. Following the execution of this Agreement, the Executive shall be granted options to purchase 125,000 shares of the common stock of Parent (the “Options”), which Options shall have an
exercise price equal to the closing price of Parent’s common stock on the trading day prior to issuance. The Options shall vest over a five-year period in equal amounts beginning on the first anniversary of the date of issuance, and shall vest
immediately upon a Change in Control (as defined in the Plan referenced below). The Options shall be subject, in all respects, to (i) the Alphatec Holdings, Inc. 2005 Employee, Director and Consultant Stock Plan (the “Plan”),
(ii) an Incentive Stock Option Agreement to be entered into by the Parent and the Executive, and (iii) the Stockholders’ Agreement dated as of March 17, 2005 between the Parent and its stockholders, to which the Executive hereby
agrees to be subject. 
 5. Termination of Employment. The Executive’s employment shall terminate upon the occurrence of any of
the following: 
 5.1 Termination by the Company for Cause. This Agreement may be terminated by the Company for Cause upon the
occurrence of any of the following (each of which shall constitute “Cause”): (i) Executive being convicted of a felony; (ii) Executive committing any act of fraud or dishonesty resulting or intended to result directly or
indirectly in personal enrichment at the expense of the Company; (iii) failure or refusal by Executive to follow policies or directives reasonably established by the President and Chief Executive Officer or his or her designee(s) that goes
uncorrected for a period of thirty (30) consecutive days after written notice has been provided to Executive; (iv) a material breach of this Agreement that goes uncorrected for a period of thirty (30) consecutive days after written
notice has been provided to Executive; (v) any gross or willful misconduct or gross negligence by Executive in the performance of Executive’s duties; (vi) egregious conduct by Executive that brings Company or any of its subsidiaries
or affiliates into public disgrace or disrepute; or (vii) a material violation of the Company’s Code of Conduct. 
 5.2
Termination Without Cause. At the election of the Company, without Cause, at any time, upon thirty (30) days written notice to Executive. 
  

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 5.3 Voluntary Termination. At the election of the Executive, for any reason, upon thirty
(30) days notice to the Company. 
 6. Effect of Termination. 
 6.1 Termination for Cause or at the Election of Executive. In the event that Executive’s employment is terminated for Cause pursuant to
Section 5.1 or at the election of the Executive pursuant to Section 5.3, the Company shall have no further obligations under this Agreement other than to pay to Executive the base salary and benefits, including payment for accrued but
untaken vacation days, otherwise payable to Executive under Sections 4.1 through 4.3 respectively through the last day of Executive’s actual employment by the Company. 
 6.2 Termination by the Company Without Cause. In the event that Executive’s employment is terminated pursuant to Section 5.2, the
Company shall continue for a period of twelve (12) months (the “Severance Period”), to pay to Executive the annual base salary then in effect in the manner set forth in Section 4.1 and payment for accrued but untaken vacation
days. During the Severance Period, Executive shall be entitled to continue to participate in all medical and similar benefit programs that the Company establishes and makes available to its management Employees. 
 7. Non-disclosure and Non-competition. 
 7.1 Proprietary Information. 
 (a) Executive agrees that all information and know-how, whether or not in writing, of a
private, secret or confidential nature concerning the Company’s business or financial affairs (collectively, “Proprietary Information”) is and shall be the exclusive property of the Company. By way of illustration, but not limitation,
Proprietary Information may include inventions, products, processes, methods, techniques, formulas, compositions, compounds, projects, developments, plans, research data, clinical data, financial data, personnel data, computer programs, and customer
and supplier lists. Executive will not disclose any Proprietary Information to others outside the Company or use the same for any unauthorized purposes without written approval by an officer of the Company, either during or after Executive’s
employment, unless and until such Proprietary Information has become public knowledge without fault by Executive. 
 (b) Executive agrees
that all files, letters, memoranda, reports, records, data, sketches, drawings, laboratory notebooks, program listings, or other written, photographic, or other tangible material containing Proprietary Information, whether created by Executive or
others, which shall come into Executive’s custody or possession, shall be and are the exclusive property of the Company to be used by Executive only in the performance of Executive’s duties for the Company. 
 (c) Executive agrees that Executive’s obligation not to disclose or use information, know-how and records of the types set forth in paragraphs
(a) and (b) above, also extends to such types of information, know-how, records and tangible property of subsidiaries and joint ventures of the Company, customers of the Company or suppliers to the Company or 

  

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other third parties who may have disclosed or entrusted the same to the Company or to Executive in the course of the Company’s business. 
 (d) Executive agrees that all Creations (as herein defined) shall be the property of the Company. “Creations” shall mean all ideas, prospect
and customer lists, inventions, research, plans for products or services, potential marketing and sales relationships, business development strategies, marketing plans, designs, logos, branding, layouts, templates, computer software (including,
without limitation, source code), computer programs, original works of authorship, copyrightable expression, characters, know-how, trade secrets, information, data, developments, discoveries, improvements, modifications, technology, methodologies,
algorithms and designs, whether or not subject to patent or copyright protection, made, conceived, expressed, developed, or actually or constructively reduced to practice by Executive solely or jointly with others to the extent relating to or
otherwise in connection with Executive’s employment by the Company. Executive agrees to cooperate in all respects regarding requests by the Company relating to the Company’s intellectual property rights in the Creations, whether such
cooperation is required during or after the termination of the employment period. 
 7.2 Noncompetition; Nonsolicitation;
Nondisparagement. 
 (a) During Executive’s employment with the Company, Executive shall not, directly or indirectly, render
services of a business, professional or commercial nature to any other person or entity that competes with the Company’s business, whether for compensation or otherwise, or engage in any business activities competitive with the Company’s
business, whether alone, as an Executive, as a partner, or as a shareholder (other than as the holder of not more than one percent of the combined voting power of the outstanding stock of a public company), officer or director of any corporation or
other business entity, or as a trustee, fiduciary or in any other similar representative capacity of any other entity. Notwithstanding the foregoing, the expenditure of reasonable amounts of time as a member of other companies’ Board of
Directors shall not be deemed a breach of this if those activities do not materially interfere with the services required under this Agreement. 
 (b) During Executive’s employment with the Company, and for a period of one (1) year following the termination of the Executive’s employment with the Company, the Executive shall not, without the prior written consent of the
Company: 
 (i) either individually or on behalf of or through any third party, directly or indirectly, solicit, divert or appropriate or
attempt to solicit, divert or appropriate, for the purpose of competing with the Company or any of its affiliates (the “Company Group”), any customer or patrons of the Company Group, or any prospective customers or patrons with respect to
which the Company Group has made a sales presentation (or similar offering of the Company’s products and services); 
 (ii) either
individually or on behalf of or through any third party, directly or indirectly, solicit, entice or persuade or attempt to solicit, entice or persuade any employee, agent, consultant or contractor of the Company Group to leave the service of the
Company Group for any reason; or 
  

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 (iii) either individually or on behalf of or through any third party, directly or indirectly, interfere
with, or attempt to interfere with, the relations between the Company Group and any vendor or supplier to the Company Group. 
 (c) During
Executive’s employment with the Company and at all times thereafter, Executive shall not make any statements that are professionally or personally disparaging about, or adverse to, the interests of the Company or any of its divisions,
affiliates, subsidiaries or other related entities, or their respective directors, officers, employees, agents, successors and assigns (collectively, “Company-Related Parties”), including, but not limited to, any statements that disparage
any person, product, service, finances, financial condition, capability or any other aspect of the business of any Company-Related Party, and that Executive will not engage in any conduct which could reasonably be expected to harm professionally or
personally the reputation of any Company-Related Party. 
 7.3 If any restriction set forth in this Section 7 is found by any court of
competent jurisdiction to be unenforceable because it extends for too long a period of time or over too great a range of activities or in too broad a geographic area, it shall be interpreted to extend only over the maximum period of time, range of
activities or geographic area as to which it may be enforceable. 
 7.4 The restrictions contained in this Section 7 are necessary for
the protection of the Proprietary Information and goodwill of the Company and are considered by Executive to be reasonable for such purpose. Executive agrees that any breach of this Section 7 will cause the Company substantial and irrevocable
damage and therefore, in the event of any such breach, in addition to such other remedies which may be available, the Company shall have the right to seek specific performance and injunctive relief. 
 8. Other Agreements. Executive represents that Executive’s performance of all the terms of this Agreement as an Executive of the Company does
not and will not breach any (i) agreement to keep in confidence proprietary information, knowledge or data acquired by Executive in confidence or in trust prior to Executive’s employment with the Company or (ii) agreement to refrain
from competing, directly or indirectly, with the business of any previous employer or any other party. 
 9. Notices. All notices
required or permitted under this Agreement shall be in writing and shall be deemed effective upon (a) a personal delivery, or (b) deposit in the United States Post Office, by registered or certified mail, postage prepaid. 
 10. Entire Agreement. This Agreement and the agreements related to the Restricted Shares constitute the entire agreement between the parties and
supersedes all prior agreements and understandings, whether written or oral relating to the subject matter of this Agreement. 
 11.
Amendment. This Agreement may be amended or modified only by a written instrument executed by both the Company and Executive. 
 12.
Successors and Assigns. This Agreement shall be binding upon and inure to the benefit of both parties and their respective successors and assigns, including any corporation into 

  

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which the Company may be merged or which may succeed to its assets or business, provided, however, that the obligations of Executive are
personal and shall not be assigned by Executive. The Company may assign this Agreement following the delivery of written notice to the Executive. 
 13. Miscellaneous. 
 13.1 No Waiver. No delay or omission by the Company in exercising any right under this Agreement
shall operate as a waiver of that or any other right. A waiver or consent given by the Company on any one occasion shall be effective only in that instance and shall not be construed as a bar or waiver of any right on any other occasion. 

13.2 Severability. In case any provision of this Agreement shall be invalid, illegal or otherwise unenforceable, the validity, legality and
enforceability of the remaining provisions shall in no way be affected or impaired thereby. 
 13.3 Governing Law. This Agreement
shall be governed by and construed and enforced in accordance with the internal laws of the State of California. 
 13.4 Consent to
Jurisdiction. Each of the parties hereto irrevocably consents and submits to the jurisdiction of the courts of the State of California, sitting in San Diego County, as the exclusive jurisdiction and venue for any actions or proceedings brought
against either party hereto, arising out of or relating to this Agreement. In any such action or proceeding brought in such courts, the parties hereto irrevocably (i) waive any objection or jurisdiction or venue, (ii) waive personal
service of the summons, complaint and other process and (iii) agree that service thereof may be made by certified or registered first-class mail directed to the party to be served. 
 13.5 Waiver of Jury Trial. Each of the parties hereto irrevocably waives its right to a trial by jury in any action arising out of or related to
this Agreement. 
 13.6 Counterparts. This Agreement may be executed in two or more counterparts, each of which shall be deemed an
original but all of which together shall constitute one and the same instrument. 
  

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 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the day and year set forth above. 

 

			
	
	
	 /S/    ROSS
SIMMONDS

	 Ross Simmonds

  
  

			
	ALPHATEC SPINE, INC.
		
	By:	 	/S/    RONALD G. HISCOCK
	 Name: Ronald G. Hiscock

	 Title: President and CEO

  
  

			
	ALPHATEC HOLDINGS, INC.
		
	By:	 	/S/    RONALD G. HISCOCK
	 Name: Ronald G. Hiscock

	 Title: President and CEO

  

 7Loan Agreement

 Exhibit 10.1 
 LOAN AGREEMENT 
 THIS LOAN AGREEMENT (this “Agreement”) made this 12th day of
October, 2006 by and between AVANTOGEN ONCOLOGY, INC., a Nevada corporation with offices at 2121 Avenue of the Stars, Suite 2550, Los Angeles, California 90067 (“Borrower”) and CHOPIN OPUS ONE, L.P., a Cayman Islands limited partnership
with offices c/o Chopin Capital Partners, LLC, 2150 Avenue of the Stars, Suite 2550, Los Angeles, California 90067 (“Lender”). 
 W I T N E S S E T H 
 WHEREAS, Borrower requires interim financing to supplement its working capital resources; and

 WHEREAS, Lender is willing to provide Borrower with such financing on the terms and conditions herein set forth. 
 NOW, THEREFORE, in consideration of the premises and the mutual covenants and agreements contained herein and other valuable consideration, the
sufficiency of which is hereby acknowledged, the parties hereto agree as follows: 
 1. The Loan. 
 a. Loan Commitment. In consideration of the issuance of warrants (the “Warrants”) in the form of Exhibit A hereto to purchase 1,000,000
shares of Borrower’s Common Stock and subject to and in accordance with the terms and conditions of this Agreement, Lender hereby agrees to lend to Borrower One Million Dollars ($1,000,000.00) (the “Loan”). Lender shall make the Loan
by wire transfer of immediately available funds to Borrower’s account with Bank of America (Century City Branch). 
 b. Note. The
Loan shall be evidenced by a promissory note of Borrower in the form of Exhibit B attached hereto (the “Note”), dated as of the date hereof, payable to Lender in the original principal amount of the Loan. 
 c. Use of Proceeds of the Loan. The proceeds of the Loan shall be used for Borrower’s general working capital purposes. 
 d. Repayment of the Loan. Borrower shall repay the Loan (together with accrued interest thereon) on December 31, 2006 (the “Maturity
Date”). Notwithstanding the foregoing, Borrower may prepay the Loan, in whole or in part, together with interest thereon, at any time without premium or penalty. 
 e. Interest. Borrower shall pay interest on the unpaid principal amount of the Loan at the rate of ten percent (10%) per annum. 

 2. Security. The Loan and the indebtedness evidenced by the Note shall be secured by a first priority security
interest in all of the assets of Borrower (the “Assets”) pursuant to that certain Security Agreement of even date herewith between Borrower and Lender in the form of Exhibit C attached hereto (the “Security Agreement”).

 3. No Liens. Borrower shall not at any time create, incur, assume or suffer to exist any lien on the Assets or agree or become or remain liable
(contingently or otherwise) to do any of the foregoing. 
 4. Events of Default. Each of the following constitutes an “Event of Default”
hereunder: 
 (a) Borrower fails to pay any amount of the Loan when demanded by Lender in accordance with the terms of this Agreement or the
Note; or 
 (b) Borrower breaches any material provision of this Agreement, the Note or the Security Agreement and such breach, if curable,
is not cured within thirty (30) days after notice of such breach is received by Borrower; or 
 (c) (i) Borrower commences any
case, proceeding or other action (A) under any existing or future law of any jurisdiction, domestic or foreign, relating to bankruptcy, insolvency or relief of debtors, seeking to have an order for relief entered with respect to Borrower, or
seeking to adjudicate Borrower bankrupt or insolvent, or seeking arrangement, adjustment, liquidation, composition or other relief with respect to Borrower or Borrower’s debts, or (B) seeking appointment of a receiver, trustee, custodian,
conservator or other similar official for Borrower or for all or any substantial part of Borrower’s assets, or Borrower makes a general assignment for the benefit of its creditors; 
 (ii) There is commenced against Borrower any case, proceeding or other action of a nature referred to in clause (i) above which
(A) results in the entry of an order for relief or any such adjudication or appointment or (B) remains undismissed, undischarged or unbonded for a period of thirty (30) days; 
 (iii) There is commenced against Borrower any case, proceeding or other action seeking issuance of a warrant of attachment, execution,
distraint or similar process against all or any substantial part of Borrower’s assets which results in the entry of an order for any such relief which shall not have been vacated, discharged, or stayed or bonded pending appeal within thirty
(30) days from the entry thereof; 
 (iv) Borrower takes any action in furtherance of, or indicating its consent to,
approval of or acquiescence in any of the acts set forth in clause (i), (ii) or (iii) above; or 
 (v) Borrower
generally does not, is unable to or admits in writing its inability to pay its debts as they become due. 
 (d) Any material representation
or warranty by Borrower in this Agreement, the Note or the Security Agreement shall have been incorrect when made; or 
  

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 (e) Any security interest created by the Security Agreement on any material Assets of the Borrower shall
cease to be, or shall be asserted by Borrower not to be, a valid, perfected first priority security interest in the Assets. 
 If an Event of Default occurs,
Lender may, upon notice to Borrower, declare the Loan and all other amounts owing under this Agreement to be due and payable forthwith, whereupon the same shall immediately become due and payable, without presentment, demand, protest or other notice
of any kind, all of which are hereby waived by Borrower to the extent permitted by applicable law. 
 5. Miscellaneous. 
 a. Notices. All notices and other communications provided for herein shall be in writing and shall be delivered by hand or overnight courier
service, mailed by certified or registered mail or sent by telecopy or confirmed email, to the parties at their addresses set forth at the beginning of this Agreement. Either party hereto may change its address for notices and other communications
hereunder by notice to the other party. All notices and other communications given to either party hereto in accordance with the provisions of this Agreement shall be deemed to have been given on the date of receipt. 
 b. Governing Law. This Agreement shall be governed by and construed in accordance with the laws of the State of California without giving effect
to applicable principles of conflicts of laws thereof. 
 c. Amendments; Waivers. No amendment, modification or waiver of, or consent
with respect to, any provision of this Agreement is enforceable as against Borrower unless such amendment, modification, waiver or consent is signed by Borrower and signed and delivered by Lender. Any amendment, modification, waiver or consent
hereunder is effective only in the specific instance and for the specific purpose for which given. 
 d. Counterparts. This Agreement
may be executed in any number of counterparts, each of which when so executed shall be deemed to be an original and all of which when taken together shall constitute one and the same agreement. Signatures may be exchanged by facsimile, and each
party hereto agrees to be bound by its own facsimile signature and to accept the facsimile signature of the other party. 
 e.
Integration. This Agreement and any agreement, document or instrument attached hereto or referred to herein, including the Security Agreement, the Note and the Warrants, integrate all the terms and conditions mentioned herein or incidental
hereto and supersede all oral negotiations and prior writings in respect to the subject matter hereof. 
 f. Headings. The headings of
the various paragraphs of this Agreement are for convenience of reference only and shall not affect the meaning or construction of any provision hereof. 
  

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 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed as of the date first
above written. 
  

			
	AVANTOGEN ONCOLOGY, INC.
		
	By:	 	  
		 	 Angela Bronow Davanzo

		 	 Chief Financial Officer

	
	CHOPIN OPUS ONE, L.P.
	
	By: Chopin Holdings, Ltd., its General Partner
	By: Greenland Ltd., Its Director
		
	By:	 	  
		 	 Angelo M. Venardos

		 	 Authorized Signatory

  

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 EXHIBIT A 
 Form of Warrant 
  

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 EXHIBIT B 
 Form of Note 
  

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 EXHIBIT C 
 Form of Security Agreement 
  

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