Document:

ADVAXIS,
INC.

 

CHANGE
IN CONTROL PLAN

 

	1.0	PURPOSE
    OF PLAN
	 	 
	1.1	Purpose.
    The purposes of the Advaxis, Inc. Change in Control Plan (the “Plan”) are to:
	 	 
	 	(a)	retain
    certain highly qualified individuals as employees of Advaxis, Inc. and/or its subsidiaries (the “Company”);
	 	 	 
	 	(b)	maintain
    the focus of such employees on the business of the Company and to mitigate the distractions caused by the possibility that
    the Company may be the target of an acquisition strategy; and
	 	 	 
	 	(c)	provide
    certain benefits to such employees if a Change in Control (as defined below) of the Company occurs and/or any employee’s
    employment is terminated in connection with such Change in Control.
	 	 
	 	The
    Plan is intended to be a “welfare plan,” but not a “pension plan,” as defined under Sections 3(1)
    and 3(2), respectively, of the Employee Retirement Income Security Act of 1974, as amended (“ERISA”).
	 	 
	2.0	DEFINITIONS
	 	 
	 	The
    following terms shall have the following meanings unless the context indicates otherwise:
	 	 
	2.1	“Beneficiary”
    shall mean a beneficiary designated in writing by a Participant to receive any Change in Control Termination Benefits
    in accordance with Section 6 below. If no beneficiary is designated by the Participant, then the Participant’s estate
    shall be deemed to be the Participant’s Beneficiary.
	 	 
	2.2	“Board”
    shall mean the Board of Directors of the Company.
	 	 
	2.3	“Cause”
    shall mean – unless otherwise defined in an employment agreement between the Participant and the Company or Subsidiary
    – a good faith determination by the Company that any of the following has occurred:

 

	 	(1)	The
    failure by Participant to substantially perform his/her assigned duties for the Company;
	 	 	 
	 	(2)	Participant
    engaging in conduct, which in the Company’s sole discretion, is materially injurious to the Company;
	 	 	 
	 	(3)	Behavior
    constituting gross negligence or willful misconduct by the Participant during the course of his/her duties;
	 	 	 
	 	(4)	The
    misappropriation of corporate assets or corporate opportunities by Participant or any other acts of dishonesty;
	 	 	 
	 	(5)	The
    breach of Participant’s fiduciary obligation to the Company;

 

    	 	 	 

    	 

    

 

	 	(6)	A
    material violation of any policy or procedure of the Company; or
	 	 	 
	 	(7)	The
    commission of, conviction of, pleading guilty to, or entering a plea of nolo contendere by Participant for any felony
    or any crime involving fraud, dishonesty, moral turpitude, or a breach of trust.

 

	2.4	“Change
    in Control” shall mean the occurrence of one of the following events:
	 	 
	 	(1)	during
    any consecutive 12-month period, individuals who, at the beginning of such period, constitute the Board of Directors of the
    Company (the “Incumbent Directors”) cease for any reason to constitute at least a majority of such Board, provided
    that any person becoming a director after the beginning of such 12-month period and whose election or nomination for election
    was approved by a vote of at least a majority of the Incumbent Directors then on the Board shall be an Incumbent Director;
    provided, however, that no individual initially elected or nominated as a director of the Company as a result of an actual
    or threatened election contest with respect to the election or removal of directors (“Election Contest”) or other
    actual or threatened solicitation of proxies or consents by or on behalf of any Person other than the Board (“Proxy
    Contest”), including by reason of any agreement intended to avoid or settle any Election Contest or Proxy Contest, shall
    be deemed an Incumbent Director; or
	 	 	 
	 	(2)	any
    person becomes a Beneficial Owner, directly or indirectly, of either (A) 50% or more of the then-outstanding shares of common
    stock of the Company (“Company Common Stock”) or (B) securities of the Company representing 35% or more of the
    combined voting power of the Company’s then outstanding securities eligible to vote for the election of directors (the
    “Company Voting Securities”); provided, however, that for purposes of this subsection (2), the following acquisitions
    of Company Common Stock or Company Voting Securities shall not constitute a Change in Control: (w) an acquisition directly
    from the Company, (x) an acquisition by the Company or a Subsidiary, (y) an acquisition by any employee benefit plan (or related
    trust) sponsored or maintained by the Company or any Subsidiary, or (z) an acquisition pursuant to a Non-Qualifying Transaction
    (as defined in subsection (3) below); or
	 	 	 
	 	(3)	the
    consummation of a reorganization, merger, consolidation, statutory share exchange or similar form of corporate transaction
    involving the Company or a Subsidiary (a “Reorganization”), or the sale or other disposition of all or substantially
    all of the Company’s assets (a “Sale”) or the acquisition of assets or stock of another corporation or other
    entity (an “Acquisition”), unless immediately following such Reorganization, Sale or Acquisition: (A) all or substantially
    all of the individuals and entities who were the Beneficial Owners, respectively, of the outstanding Company Common Stock
    and outstanding Company Voting Securities immediately prior to such Reorganization, Sale or Acquisition beneficially own,
    directly or indirectly, more than 50% of, respectively, the then outstanding shares of common stock and the combined voting
    power of the then outstanding voting securities entitled to vote generally in the election of directors, as the case may be,
    of the entity resulting from such Reorganization, Sale or Acquisition (including, without limitation, an entity which as a
    result of such transaction owns the Company or all or substantially all of the Company’s assets or stock either directly
    or through one or more subsidiaries, the “Surviving Entity”) in substantially the same proportions as their ownership,
    immediately prior to such Reorganization, Sale or Acquisition, of the outstanding Company Common Stock and the outstanding
    Company Voting Securities, as the case may be, and (B) no person (other than (x) the Company or any Subsidiary, (y) the Surviving
    Entity or its ultimate parent entity, or (z) any employee benefit plan (or related trust) sponsored or maintained by any of
    the foregoing) is the Beneficial Owner, directly or indirectly, of 35% or more of the total common stock or 35% or more of
    the total voting power of the outstanding voting securities eligible to elect directors of the Surviving Entity, and (C) at
    least a majority of the members of the board of directors of the Surviving Entity were Incumbent Directors at the time of
    the Board’s approval of the execution of the initial agreement providing for such Reorganization, Sale or Acquisition
    (any Reorganization, Sale or Acquisition which satisfies all of the criteria specified in (A), (B) and (C) above shall be
    deemed to be a “Non-Qualifying Transaction”); or

 

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	 	(4)	approval
    by the stockholders of the Company of a complete liquidation or dissolution of the Company.
	 	 
	2.5	“Change
    in Control Date” shall mean the date that a Change in Control first occurs.
	 	 
	2.6	“Change
    in Control Equity Acceleration” shall mean the acceleration of vesting of outstanding equity awards described in
    Section 5 below.
	 	 
	2.7	“Change in Control Termination”
    shall mean a termination of the Participant’s employment:

 

	 	(1)	by
    the Company without Cause during the period beginning 3 months prior to the Change in Control Date and ending 18 months after
    the Change in Control Date, or
	 	 	 
	 	(2)	if
    the Participant has been designated by the Committee as a Tier 1 Participant or a Tier 2 Participant in accordance with Section
    3.2 below, by the Participant for Good Reason during the period beginning 3 months prior to the date of the Change in Control
    and ending 18 months after the Change in Control Date.
	 	 	 
	2.8	“Change
    in Control Termination Benefits” shall mean the benefits described in Section 6 below.
	 	 
	2.9	“Code”
    shall mean the Internal Revenue Code of 1986, as amended from time to time.
	 	 
	2.10	“Committee”
    shall mean (i) the Compensation Committee of the Board or (ii) a committee or subcommittee of the Board appointed by the
    Board from among its members.
	 	 
	2.11	“Company”
    shall mean Advaxis, Inc., a Delaware corporation, including any successor entity or any successor to the assets of the
    Company that has assumed the Plan.
	 	 
	2.12	“Competitive
    Activity” shall mean the Participant’s engaging in an activity – whether as an employee, consultant,
    principal, member, agent, officer, director, partner or shareholder (except as a less than 1% shareholder of a publicly traded
    company) – that is competitive with any business of the Company or any Subsidiary conducted by the Company or such Subsidiary
    at any time during the Noncompetition/Nonsolicitation Period; provided, however, that the Participant may be employed
    by or otherwise associated with:

 

	 	 	(i)	 a
    business of which a subsidiary, division, segment, unit, etc. is in competition with the Company or any Subsidiary but as
    to which such subsidiary, division, segment, unit, etc. the Participant has absolutely no direct or indirect responsibilities
    or involvement, or

 

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	 	 	(ii)	a
    company where the Competitive Activity is:
	 	 	 	 
	 	 	 	(A)	from
    the perspective of such company, de minimis with respect to the business of such company and its affiliates, and
	 	 	 	 	 
	 	 	 	(B)	from
    the perspective of the Company or any Subsidiary, not in material competition with the Company or any Subsidiary.
	 	 
	2.13	“Effective
    Date” shall mean the date the Board adopts the Plan.
	 	 
	2.14	“Employee”
    shall mean a regular full-time employee of the Company or any Subsidiary.

 

	2.15	“Good
    Reason” shall mean – unless otherwise defined in an employment agreement between the Participant and the Company
    or Subsidiary – the occurrence of any of the following within the 60-day period preceding a Termination Date:
	 	 
	 	(1)	a
    material adverse diminution of the Participant’s authority, duties or responsibilities, or the assignment to the Participant
    of authority, duties or responsibilities that are materially inconsistent with his or her titles, authority, duties and/or
    responsibilities in a manner materially adverse to the Participant; or
	 	 	 
	 	(2)	a
    material reduction in the Participant’s base salary or Target Annual Bonus without the Participant’s prior written
    consent (other than any reduction applicable to Employees generally); or
	 	 	 
	 	(3)	an
    actual change in the Participant’s principal work location by more than 75 miles and more than 75 miles from the Participant’s
    principal place of abode as of the date of such change in job location without the Participant’s prior written consent;
    or
	 	 	 
	 	(4)	a
    failure of any successor to the Company (whether through an asset sale or other sale of all or substantially all of the Company
    through which assumption of this Agreement would be required for it to remain in force after consummation of the sale) to
    assume this Plan and the Company’s obligations under this Plan.

 

	2.16	“Health
    Continuation Period” shall mean the period commencing on the Termination Date and continuing until the end of the
    applicable period as shown on Schedule A.
	 	 
	2.17	“Noncompetition/Nonsolicitation
    Period” shall mean the period commencing on the Effective Date and continuing until the end of the applicable period
    as shown on Schedule A.
	 	 
	2.18	“Participant”
    shall mean any Employee who has been designated to participate in the Plan under Section 3 below.
	 	 
	2.19	“Plan”
    shall mean the Advaxis, Inc. Change in Control Plan.
	 	 
	2.20	“Salary”
    shall mean the highest annual base salary paid to the Participant during the 12-month period immediately preceding the
    earlier of (i) the Termination Date or the Change in Control Date, with such amount increased (if applicable) to take into
    account any elective or mandatory deferrals.

 

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	2.21	“Severance
    Multiplier” shall mean the multiplier that shall be used to determine cash severance paid to a Participant in accordance
    with Schedule A and Section 6.2 below.
	 	 
	2.22	“Subsidiary”
    shall mean a corporation of which the Company directly or indirectly owns more than 50 percent of the “voting stock”
    (meaning the capital stock of any class or classes having general voting power under ordinary circumstances, in the absence
    of contingencies, to elect the directors of a corporation) or any other business entity in which the Company directly or indirectly
    has an ownership interest of more than 50 percent.
	 	 
	2.23	“Target
    Annual Bonus” means, with respect to any Participant, the Participant’s target bonus opportunity under the
    annual corporate incentive plan applicable to the Participant.
	 	 
	2.24	“Terminated
    Participant” shall mean a Participant whose employment with the Company and/or a Subsidiary has been terminated
    and which qualifies as a Change in Control Termination.
	 	 
	2.25	“Termination
    Date” shall mean the date a Terminated Participant’s employment with the Company and/or a Subsidiary is terminated.
	 	 
	2.26	“Tier
    1 Participant” shall mean a Participant who has been designated by the Committee as a Tier 1 Participant in accordance
    with Section 3.2 below.
	 	 
	2.27	“Tier
    2 Participant” shall mean a Participant who has been designated by the Committee as a Tier 2 Participant in accordance
    with Section 3.2 below.
	 	 
	2.28	“Tier
    3 Participant” shall mean a Participant who has been designated by the Committee as a Tier 3 Participant in accordance
    with Section 3.2 below.
	 	 
	3.0	ELIGIBILITY
    AND PARTICIPATION
	 	 
	3.1	Eligibility.
    All Employees of the Company shall be eligible to participate in the Plan.
	 	 
	3.2	Participation.
    Participants shall consist of such Employees as the Committee in its sole discretion designates to participate in the Plan;
    provided, however, that the Committee shall not designate an Employee as a new Participant following a Change in Control
    Date. At the time the Committee designates an Employee as a Participant, the Committee shall also designate whether such Employee
    is a Tier 1 Participant, a Tier 2 Participant, or a Tier 3 Participant. The Committee may, in its sole discretion, terminate
    a Participant’s participation in the Plan at any time prior to the beginning of the 180-day period ending on the Change
    in Control Date.
	 	 
	4.0	ADMINISTRATION
	 	 
	4.1	Responsibility. The Committee shall have
    the responsibility, in its sole discretion, to control, operate, manage and administer the Plan in accordance with its terms.
	 	 
	4.2	Authority of the Committee. The Committee
    shall have the maximum discretionary authority permitted by law that may be necessary to enable it to discharge its responsibilities
    with respect to the Plan, including but not limited to the following:

 

	 	(a)	to
    determine eligibility for participation in the Plan;
	 	 	 
	 	(b)	to
    designate Participants;

 

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	 	(c)	to
    correct any defect, supply any omission, or reconcile any inconsistency in the Plan in such manner and to such extent as it
    shall deem appropriate in its sole discretion to carry the same into effect;
	 	 	 
	 	(d)	to
    issue administrative guidelines as an aid to administer the Plan and make changes in such guidelines as it from time to time
    deems proper;
	 	 	 
	 	(e)	to
    make rules for carrying out and administering the Plan and make changes in such rules as it from time to time deems proper;
	 	 	 
	 	(f)	to
    make reasonable determinations as to a Participant’s eligibility for benefits under the Plan, including determinations
    as to Cause and Good Reason; and
	 	 	 
	 	(g)	to
    take any and all other actions it deems necessary or advisable for the proper operation or administration of the Plan.

 

	4.3	Action
    by the Committee. The Committee may act only by a majority of its members. Any determination of the Committee may be made,
    without a meeting, by a writing or writings signed by all of the members of the Committee. In addition, the Committee may
    authorize any one or more of its members to execute and deliver documents on behalf of the Committee.
	 	 
	4.4	Delegation
    of Authority. The Committee may delegate to one or more of its members, or to one or more agents, such administrative
    duties as it may deem advisable; provided, however, that any such delegation shall be in writing. In addition, the
    Committee, or any person to whom it has delegated duties as aforesaid, may employ one or more persons to render advice with
    respect to any responsibility the Committee or such person may have under the Plan. The Committee may employ such legal or
    other counsel, consultants and agents as it may deem desirable for the administration of the Plan and may rely upon any opinion
    or computation received from any such counsel, consultant or agent. Expenses incurred by the Committee in the engagement of
    such counsel, consultant or agent shall be paid by the Company, or the Subsidiary whose employees have benefited from the
    Plan, as determined by the Committee.
	 	 
	4.5	Determinations
    and Interpretations by the Committee. All determinations and interpretations made by the Committee shall be binding and
    conclusive to the maximum extent permitted by law on all Participants and their heirs, successors, and legal representatives.
	 	 
	4.6	Liability.
    No member of the Board, no member of the Committee and no employee of the Company shall be liable for any act or failure to
    act hereunder, except in circumstances involving his or her bad faith, gross negligence or willful misconduct, or for any
    act or failure to act hereunder by any other member or employee or by any agent to whom duties in connection with the administration
    of the Plan have been delegated.
	 	 
	4.7	Indemnification.
    The Company shall indemnify members of the Committee and any agent of the Committee who is an employee of the Company, against
    any and all liabilities or expenses to which they may be subjected by reason of any act or failure to act with respect to
    their duties on behalf of the Plan, except in circumstances involving such person’s bad faith, gross negligence or willful
    misconduct.

 

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	5.0	CHANGE
    IN CONTROL EQUITY ACCELERATION (SINGLE-TRIGGER)
	 	 
	5.1	Change
    in Control Equity Acceleration. Subject to Section 7.1, unvested equity rights held by Tier 1 Participants and Tier 2
    Participants shall be accelerated as follows: (i) outstanding stock options and other awards in the nature of rights that
    may be exercised shall become fully vested and exercisable, (ii) time-based restrictions on restricted stock, restricted stock
    units and other equity awards shall lapse and the awards shall become fully vested, and (iii) performance-based equity awards
    shall become vested and shall be deemed earned based on an assumed achievement of all relevant performance goals at “target”
    levels, and shall payout pro rata to reflect the portion of the performance period that had elapsed prior to the Change in
    Control. For avoidance of doubt, unvested equity rights held by Tier 3 Participants shall not be subject to the provisions
    of this Section 5.
	 	 
	6.0	CHANGE IN CONTROL TERMINATION BENEFITS (DOUBLE-TRIGGER)
	 	 
	6.1	Accrued
    Obligations. The Company shall pay to the Terminated Participant during the 30-day period following the Termination Date,
    a lump sum cash payment equal to the Participant’s earned but unpaid Salary, plus unreimbursed expenses, plus any and
    all other Company obligations that are accrued and due and owing to the Terminated Participant.
	 	 
	6.2	Cash
    Severance. Subject to Section 7.1, the Company shall pay to the Terminated Participant during the 60-day period following
    the later of the Change in Control Date or the Termination Date, a lump sum cash payment equal to the sum of:

 

	 	(a)	a
    pro rata Target Annual Bonus with respect to the year that the Termination Date occurs (pro rated to reflect the number of
    whole months between January 1 and the Termination Date), plus
	 	 	 
	 	(b)	(i)
    with respect to Tier 1 and Tier 2 Participants only, the product of (x) the Severance Multiplier times (y) the sum of the
    Terminated Participant’s (A) Salary plus (B) Target Annual Bonus with respect to the year that the Termination Date
    occurs, or 
	 	 	 
	 	 	(ii)
    with respect to Tier 3 Participants only, the product of (x) the Severance Multiplier times (y) the sum of the Terminated
    Participant’s Salary.

 

	6.3	Welfare-Benefit
    Arrangements. Subject to Section 7.1, if the Terminated Participant elects to continue participation in the Company’s
    group health and welfare plans under COBRA, then during the Health Continuation Period as shown on Schedule A, or until Executive
    obtains other gainful employment and is covered by a health and medical plan, whichever occurs first, the Company shall pay
    or reimburse the Terminated Participant for the full cost of such coverage. Unless otherwise provided for in any written agreement
    between the Company and a Terminated Participant, or as otherwise agreed to by the Committee in its sole discretion, all other
    welfare benefits shall cease as of the Termination Date.
	 	 
	6.4	Payment
    of Change in Control Termination Benefits to Beneficiaries. In the event of the Terminated Participant’s death,
    all Change in Control Termination Benefits that would have been paid to the Terminated Participant under this Section 6 but
    for his or her death, shall be paid to the Terminated Participant’s Beneficiary.
	 	 
	6.5	Other
    Benefits. Notwithstanding anything contained in the Plan to the contrary, the Company or the Committee may, in its sole
    discretion, provide benefits in addition to the benefits described under this Section 6.

 

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	7.0	PARTICIPANT
    OBLIGATIONS
	 	 
	7.1	Waiver
    and Release. As a condition precedent for receiving the Change in Control Equity Acceleration provided under Section 5
    above and the Change in Control Termination Benefits provided under Section 6 above, a Terminated Participant shall execute
    a waiver and release in a form acceptable to the Company. Such release must be executed and all revocation periods shall have
    expired within 60 days following the later of (x) the Change in Control Date or (y) the Termination Date; failing which Change
    in Control Termination Benefits (other than Accrued Obligations set forth under Section 6.1 above) shall be forfeited. If
    Change in Control Termination Benefits constitute non-exempt deferred compensation for purposes of Section 409A of the Code,
    and if such 60-day period begins in one calendar year and ends in the next calendar year, the payment or benefit shall not
    be made or commence before the second such calendar year, even if the release becomes irrevocable in the first such calendar
    year.
	 	 
	7.2	Noncompetition.
    During the Noncompetition/Nonsolicitation Period, a Terminated Participant shall not at any time, directly or indirectly,
    engage in Competitive Activity.
	 	 
	7.3	Nonsolicitation.
    During the Noncompetition/Nonsolicitation Period, a Terminated Participant shall not at any time, directly or indirectly,
    solicit (x) any customer or client of the Company or any Subsidiary with respect to a Competitive Activity or (y) any employee
    of the Company or any Subsidiary for the purpose of causing such employee to terminate his or her employment with the Company
    or such Subsidiary.
	 	 
	7.4	Enforcement.
    If a Terminated Participant violates or threatens to violate Section 7.2 or Section 7.3 above, the Company shall not have
    an adequate remedy at law. Accordingly, the Company shall be entitled to such equitable and injunctive relief as may be available
    to restrain the Terminated Participant and any business, firm, partnership, individual, corporation or entity participating
    in the breach or threatened breach from the violation of the provisions of Section 7.2 or 7.3 above. Nothing in the Plan shall
    be construed as prohibiting the Company from pursuing any other remedies available at law or in equity for breach or threatened
    breach of Section 7.2 or 7.3 above, including the recovery of damages.
	 	 
	7.5	Confidentiality. At all times prior to and
    after the Change in Control Date, a Participant shall not disclose to anyone or make use of any trade secret or proprietary
    or confidential information of the Company, including such trade secret or proprietary or confidential information of any
    customer or other entity to which the Company owes an obligation not to disclose such information, which he or she acquires
    during his or her employment with the Company, including but not limited to records kept in the ordinary course of business,
    except:

 

	 	 	(i)	as
    such disclosure or use may be required or appropriate in connection with his or her work as an employee of the Company;
	 	 	 	 
	 	 	(ii)	when
    required to do so by a court of law, by any governmental agency having supervisory authority over the business of the Company
    or by any administrative or legislative body (including a committee thereof) with apparent jurisdiction to order him or her
    to divulge, disclose or make accessible such information;
	 	 	 	 
	 	 	(iii)	as
    to such confidential information that becomes generally known to the public or trade without his or her violation of this
    Section 7.5; or

 

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	 	 	(iv)	to
    the Participant’s spouse and/or his or her personal tax and financial advisors as reasonably necessary or appropriate
    to advance the Participant’s tax, financial and other personal planning (each an “Exempt Person”), provided,
    however , that any disclosure or use of any trade secret or proprietary or confidential information of the Company by
    an Exempt Person shall be deemed to be a breach of this Section 7.5 by the Participant.

 

	7.6	Return
    of Company Property. Immediately following the Termination Date, a Participant shall immediately return all Company property
    in his or her possession, including but not limited to all computer equipment (hardware and software), telephones, facsimile
    machines, palm pilots and other communication devices, credit cards, office keys, security access cards, badges, identification
    cards and all copies (including drafts) of any documentation or information (however stored) relating to the business of the
    Company, its customers and clients or its prospective customers and clients.
	 	 
	7.7	Cooperation.
    Following the Termination Date, a Participant shall give his or her assistance and cooperation willingly, upon reasonable
    advance notice with due consideration for his or her other business or personal commitments, in any matter relating to his
    or her position with the Company, or his or her expertise or experience as the Company may reasonably request, including his
    or her attendance and truthful testimony where deemed appropriate by the Company, with respect to any investigation or the
    Company’s defense or prosecution of any existing or future claims or litigations or other proceeding relating to matters
    in which he or she was involved or potentially had knowledge by virtue of his or her employment with the Company. In no event
    shall his or her cooperation materially interfere with his or her services for a subsequent employer or other similar service
    recipient. The Company agrees that (i) it will promptly reimburse the Terminated Participant for his or her reasonable and
    documented expenses in connection with his or her rendering assistance and/or cooperation under this Section 7.7, upon his
    or her presentation of documentation for such expenses and (ii) the Terminated Participant will be reasonably compensated
    for any continued material services as required under this Section 7.7.
	 	 
	8.0	CLAIMS
	 	 
	8.1	Claims
    Procedure. If any Participant or Beneficiary, or his or her legal representative, has a claim for benefits which is not
    being paid, such claimant may file a written claim with the Committee setting forth the amount and nature of the claim, supporting
    facts, and the claimant’s address. Written notice of the disposition of a claim by the Committee shall be furnished
    to the claimant within 90 days after the claim is filed. In the event of special circumstances, the Committee may extend the
    period for determination for up to an additional 90 days, in which case it shall so advise the claimant. If the claim is denied,
    the reasons for the denial shall be specifically set forth in writing, pertinent provisions of the Plan shall be cited, including
    an explanation of the Plan’s claim review procedure, and, if the claim is perfectible, an explanation as to how the
    claimant can perfect the claim shall be provided.
	 	 
	8.2	Claims
    Review Procedure. If a claimant whose claim has been denied wishes further consideration of his or her claim, he or she
    may request the Committee to review his or her claim in a written statement of the claimant’s position filed with the
    Committee no later than 60 days after receipt of the written notification provided for in Section 8.1 above. The Committee
    shall fully and fairly review the matter and shall promptly advise the claimant, in writing, of its decision within the next
    60 days. Due to special circumstances, the Committee may extend the period for determination for up to an additional 60 days.

 

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	8.3	Dispute
    Resolution. Any disputes arising under or in connection with the Plan shall be resolved by binding arbitration, to be
    held in New York City in accordance with the rules and procedures of the American Arbitration Association. Judgment upon the
    award rendered by the arbitrator may be entered in any court having jurisdiction thereof.
	 	 
	8.4	Reimbursement
    of Expenses. If there is any dispute between the Company and a Participant with respect to a claim under the Plan, the
    Company shall reimburse such Participant all reasonable fees, costs and expenses incurred by such Participant with respect
    to such disputed claim; provided, however, that (i) such Participant is the prevailing party with respect to such disputed
    claim or (ii) the disputed claim is settled.

 

	9.0	TAXES
	 	 
	9.1	Withholding
    Taxes. The Company shall be entitled to withhold from any and all payments made to a Participant under the Plan all federal,
    state, local and/or other taxes or imposts which the Company determines are required to be so withheld from such payments
    or by reason of any other payments made to or on behalf of the Participant or for his or her benefit hereunder.
	 	 
	9.2	Mandatory
    Reduction of Payments in Certain Events.
	 	 
	 	(a)	Notwithstanding
    anything in this Plan to the contrary, in the event it shall be determined that any payment or distribution by the Company
    to or for the benefit of a Participant (whether paid or payable or distributed or distributable pursuant to the terms of this
    Plan or otherwise) (such benefits, payments or distributions are hereinafter referred to as “Payments”) would,
    if paid, be subject to the excise tax (the “Excise Tax”) imposed by Section 4999 of the Code, then, prior to the
    making of any Payments to the Participant, a calculation shall be made comparing (i) the net after-tax benefit to the Participant
    of the Payments after payment by the Participant of the Excise Tax, to (ii) the net after-tax benefit to the Participant if
    the Payments had been limited to the extent necessary to avoid being subject to the Excise Tax. If the amount calculated under
    (i) above is less than the amount calculated under (ii) above, then the Payments shall be limited to the extent necessary
    to avoid being subject to the Excise Tax (the “Reduced Amount”). The reduction of the Payments due hereunder,
    if applicable, shall be made by first reducing cash Payments and then, to the extent necessary, reducing those Payments having
    the next highest ratio of Parachute Value to actual present value of such Payments as of the date of the change in control
    transaction, as determined by the Determination Firm (as defined in Section 9.2(b) below). For purposes of this Section 9.2,
    present value shall be determined in accordance with Section 280G(d)(4) of the Code. For purposes of this Section 9.2, the
    “Parachute Value” of a Payment means the present value as of the date of the change in control transaction of
    the portion of such Payment that constitutes a “parachute payment” under Section 280G(b)(2) of the Code, as determined
    by the Determination Firm for purposes of determining whether and to what extent the Excise Tax will apply to such Payment.
	 	 	 
	 	(b)	All
    determinations required to be made under this Section 9.2, including whether an Excise Tax would otherwise be imposed, whether
    the Payments shall be reduced, the amount of the Reduced Amount, and the assumptions to be utilized in arriving at such determinations,
    shall be made by an independent, nationally recognized accounting firm or compensation consulting firm mutually acceptable
    to the Company and the Participant (the “Determination Firm”) which shall provide detailed supporting calculations
    both to the Company and the Participant within 15 business days after the receipt of notice from the Participant that a Payment
    is due to be made, or such earlier time as is requested by the Company. All fees and expenses of the Determination Firm shall
    be borne solely by the Company. Any determination by the Determination Firm shall be binding upon the Company and the Participant.
    As a result of the uncertainty in the application of Section 4999 of the Code at the time of the initial determination by
    the Determination Firm hereunder, it is possible that Payments which the Participant was entitled to, but did not receive
    pursuant to Section 9.2(a), could have been made without the imposition of the Excise Tax (“Underpayment”), consistent
    with the calculations required to be made hereunder. In such event, the Determination Firm shall determine the amount of the
    Underpayment that has occurred and any such Underpayment shall be promptly paid by the Company to or for the benefit of the
    Participant but no later than March 15 of the year after the year in which the Underpayment is determined to exist, which
    is when the legally binding right to such Underpayment arises.

 

    	 	10	 

    	 

    

 

	 	(c)	In
    the event that the provisions of Code Section 280G and 4999 or any successor provisions are repealed without succession, this
    Section 9.2 shall be of no further force or effect.
	 	 
	9.3	Code
    Section 409A. 
	 	 
	 	(a)	Notwithstanding
    anything in this Plan to the contrary, to the extent that any amount or benefit that would constitute non-exempt “deferred
    compensation” for purposes of Section 409A of the Internal Revenue Code of 1986, as amended (the “Code”)
    would otherwise be payable or distributable hereunder by reason of a Participant’s termination of employment, such amount
    or benefit will not be payable or distributable to the Participant by reason of such circumstance unless (i) the circumstances
    giving rise to such termination of employment meet any description or definition of “separation from service”
    in Section 409A of the Code and applicable regulations (without giving effect to any elective provisions that may be available
    under such definition), or (ii) the payment or distribution of such amount or benefit would be exempt from the application
    of Section 409A of the Code by reason of the short-term deferral exemption or otherwise. This provision does not prohibit
    the vesting of any amount upon a termination of employment, however defined. If this provision prevents the payment or distribution
    of any amount or benefit, such payment or distribution shall be made on the date, if any, on which an event occurs that constitutes
    a Section 409A-compliant “separation from service.”
	 	 	 
	 	b.	Notwithstanding
    anything in this Plan to the contrary, if any amount or benefit that would constitute non-exempt “deferred compensation”
    for purposes of Section 409A of the Code would otherwise be payable or distributable under this Plan by reason of a Participant’s
    separation from service during a period in which he or she is a Specified Employee (as defined below), then, subject to any
    permissible acceleration of payment by the Company under Treas. Reg. Section 1.409A-3(j)(4)(ii) (domestic relations order),
    (j)(4)(iii) (conflicts of interest), or (j)(4)(vi) (payment of employment taxes), the Participant’s right to receive
    payment or distribution of such non-exempt deferred compensation will be delayed until the earlier of the Participant’s
    death or the first business day of the seventh month following the Participant’s separation from service.
	 	 	 
	 	 	For
    purposes of this Plan, the term “Specified Employee” has the meaning given such term in Code Section 409A and
    the final regulations thereunder (“Final 409A Regulations”), provided, however, that, as permitted in the Final
    409A Regulations, the Company’s Specified Employees and its application of the six-month delay rule of Code Section
    409A(a)(2)(B)(i) shall be determined in accordance with rules adopted by the Company, which shall be applied consistently
    with respect to all nonqualified deferred compensation arrangements of the Company, including this Plan.

 

    	 	11	 

    	 

    

 

	9.4	No
    Guarantee of Tax Consequences. No person connected with the Plan in any capacity, including, but not limited to, the Company
    and any Subsidiary and their directors, officers, agents and employees makes any representation, commitment, or guarantee
    that any tax treatment, including, but not limited to, federal, state and local income, estate and gift tax treatment, will
    be applicable with respect to amounts deferred under the Plan, or paid to or for the benefit of a Participant under the Plan,
    or that such tax treatment will apply to or be available to a Participant on account of participation in the Plan.

 

	10.0	TERM
    OF PLAN; AMENDMENT AND TERMINATION OF PLAN
	 	 
	10.1	Term
    of Plan. The Plan shall be effective as of the Effective Date and shall remain in effect until the Board terminates the
    Plan.
	 	 
	10.2	Amendment
    of Plan. The Plan may be amended by the Board at any time with or without prior notice; provided, however, that
    the Plan shall not be amended on a Change in Control Date or during the 3-year period following such Change in Control Date.
	 	 
	10.3	Termination
    of Plan. The Plan may be terminated or suspended by the Board at any time with or without prior notice; provided, however,
    that the Plan shall not be terminated or suspended on a Change in Control Date or during the 3-year period following such
    Change in Control Date.
	 	 
	10.4	No
    Adverse Effect. If the Plan is amended, terminated, or suspended in accordance with Sections 10.2 or 10.3 above, such
    action shall not adversely affect the benefits of any Participant.
	 	 
	11.0	MISCELLANEOUS
	 	 
	11.1	Non-Duplication
    of Benefits. Change in Control Termination Benefits shall be reduced by any severance, layoff or termination payments
    or benefits made or provided by the Company or any Subsidiary to the Participant pursuant to (i) any severance plan, program,
    policy or arrangement of the Company or any Subsidiary not otherwise referred to in the Plan, (ii) any employment agreement
    between the Company or any Subsidiary and the Participant, and (iii) any federal, state or local statute, rule, regulation
    or ordinance.
	 	 
	11.2	No
    Right, Title, or Interest in Company Assets. Participants shall have no right, title, or interest whatsoever in or to
    any assets of the Company or any investments which the Company may make to aid it in meeting its obligations under the Plan.
    Nothing contained in the Plan, and no action taken pursuant to its provisions, shall create or be construed to create a trust
    of any kind, or a fiduciary relationship between the Company and any Participant, Beneficiary, legal representative or any
    other person. To the extent that any person acquires a right to receive payments from the Company under the Plan, such right
    shall be no greater than the right of an unsecured general creditor of the Company. Subject to this Section 11.2, all payments
    to be made hereunder shall be paid from the general funds of the Company and no special or separate fund shall be established
    and no segregation of assets shall be made to assure payment of such amounts; provided, however , that the Company
    may establish a grantor trust to provide for the payment of the benefits under the Plan of which the Company is the grantor
    within the meaning of subpart E, part I, subchapter J, chapter 1, subtitle A of the Code and under which the assets held by
    such trust will be subject to the claims of the Company’s general creditors under federal and state law in the event
    of the Company’s insolvency.
	 	 
	11.3	No
    Right to Continued Employment. The Participant’s rights, if any, to continue to serve the Company as an employee
    shall not be enlarged or otherwise affected by his or her designation as a Participant under the Plan, and the Company or
    the applicable Subsidiary reserves the right to terminate the employment of any employee at any time. The adoption of the
    Plan shall not be deemed to give any employee, or any other individual any right to be selected as a Participant or to continued
    employment with the Company or any Subsidiary.

 

    	 	12	 

    	 

    

 

	11.4	Other
    Rights. The Plan shall not affect or impair the rights or obligations of the Company or a Participant under any other
    written plan, contract, arrangement, or pension, profit sharing or other compensation plan.
	 	 
	11.5	Governing
    Law. The Plan shall be governed by and construed in accordance with the laws of the State of Delaware without reference
    to principles of conflict of laws, except as superseded by ERISA and other applicable federal law.
	 	 
	11.6	Severability.
    If any term or condition of the Plan shall be invalid or unenforceable to any extent or in any application, then the remainder
    of the Plan, with the exception of such invalid or unenforceable provision, shall not be affected thereby and shall continue
    in effect and application to its fullest extent.
	 	 
	11.7	Incapacity.
    If the Committee determines that a Participant or a Beneficiary is unable to care for his or her affairs because of illness
    or accident or because he or she is a minor, any benefit due the Participant or Beneficiary may be paid to the Participant’s
    spouse or to any other person deemed by the Committee to have incurred expense for such Participant (including a duly appointed
    guardian, committee or other legal representative), and any such payment shall be a complete discharge of the Company’s
    obligation hereunder.
	 	 
	11.8	Transferability
    of Rights. The Company shall have the unrestricted right to transfer its obligations under the Plan with respect to one
    or more Participants to any person, including, but not limited to, any purchaser of all or any part of the Company’s
    business. No Participant or Beneficiary shall have any right to commute, encumber, transfer or otherwise dispose of or alienate
    any present or future right or expectancy which the Participant or Beneficiary may have at any time to receive payments of
    benefits hereunder, which benefits and the right thereto are expressly declared to be non-assignable and nontransferable,
    except to the extent required by law. Any attempt to transfer or assign a benefit, or any rights granted hereunder, by a Participant
    or the spouse of a Participant shall, in the sole discretion of the Committee (after consideration of such facts as it deems
    pertinent), be grounds for terminating any rights of the Participant or Beneficiary to any portion of the Plan benefits not
    previously paid.

 

    	 	13	 

    	 

    

 

SCHEDULE
A

 

	TIER	 	SEVERANCE
 MULTIPLIER	 	HEALTH 

    CONTINUATION
 PERIOD	 	NONCOMPETITION/
 NONSOLICITATION

    PERIOD
	1	 	1.5x	 	18 months	 	12 months
	2	 	1.0x	 	12 months	 	12 months
	3	 	0.5x	 	6 months	 	6 months

 

Tier
participation:

 

Tier
1: CEO

Tier
2: Vice President and above

Tier
3: All other Participants

 

    	 	14EX-10.22

 Exhibit 10.22 

XENOPORT, INC. 

RESTRICTED STOCK UNIT GRANT NOTICE 

(2014 EQUITY INCENTIVE PLAN) 

XenoPort, Inc. (the “Company”), pursuant to Section 6(b) of the Company’s 2014 Equity Incentive Plan (the
“Plan”), hereby awards to Participant a Restricted Stock Unit Award covering the number of restricted stock units (the “Stock Units”) set forth below (the “Award”). This Award
shall be evidenced by a Restricted Stock Unit Award Agreement (the “Award Agreement”). This Award is subject to all of the terms and conditions as set forth herein and in the applicable Award Agreement and the Plan, each of
which are attached hereto and incorporated herein in their entirety. 
  

			
	Participant:	 	 
	Date of Grant:	 	 
	Vesting Commencement Date:	 	 
	Number of Stock Units:	 	 
	Payment for Common Stock:	 	Participant’s services to the Company

 Vesting Schedule: 
  

					
	 Shares
	 	 Vest Type
	 	 Full Vest Date

		 		 	
		 		 	
		 		 	
		 		 	
		 		 	

 Delivery Schedule: Delivery of one share of Common Stock for each Stock Unit that vests shall occur at the time set
forth in Section 3(a) of the Award Agreement.  
 Additional Terms/Acknowledgements: Participant acknowledges receipt of, and understands
and agrees to, this Grant Notice, the Award Agreement and the Plan. Participant further acknowledges that as of the Date of Grant, this Grant Notice, the Award Agreement and the Plan set forth the entire understanding between Participant and the
Company regarding the award of the Stock Units and the underlying Common Stock and supersede all prior oral and written agreements on that subject with the exception of Stock Awards previously granted and delivered to Participant under the Plan.

 XENOPORT, INC. 

By:
                                         
    
 William G. Harris 

Senior Vice President of Finance and 

Chief Financial Officer 

ATTACHMENTS:        Award Agreement, 2014 Equity Incentive Plan Prospectus and
2014 Equity Incentive Plan 

 XENOPORT, INC. 

2014 EQUITY INCENTIVE PLAN 

RESTRICTED STOCK UNIT AWARD AGREEMENT 

Pursuant to the Restricted Stock Unit Grant Notice (“Grant Notice”) and this Restricted Stock Unit Award Agreement
(“Agreement”), XenoPort, Inc. (the “Company”) has awarded you a Restricted Stock Unit Award pursuant to Section 6(b) of the Company’s 2014 Equity Incentive Plan (the
“Plan”) for the number of Stock Units as indicated in the Grant Notice (collectively, the “Award”). Defined terms not explicitly defined in this Agreement but defined in the Plan shall have the same
definitions as in the Plan. Subject to adjustment and the terms and conditions as provided herein and in the Plan, each Stock Unit shall represent the right to receive one (1) share of Common Stock. 

The details of your Award, in addition to those set forth in the Grant Notice, are as follows. 

NUMBER OF STOCK UNITS AND SHARES
OF COMMON STOCK. The number of Stock Units in your Award is set forth in the Grant Notice. 

The number of Stock Units subject to your Award and the number of shares of Common Stock deliverable with respect to such Stock Units may be
adjusted from time to time for Capitalization Adjustments as described in the Plan. You shall receive no benefit or adjustment to your Award with respect to any cash dividend or other distribution that does not result in a Capitalization Adjustment
pursuant to the Plan; provided, however, that this sentence shall not apply with respect to any shares of Common Stock that are delivered to you in connection with your Award after such shares have been delivered to you. 

Any additional Stock Units, shares of Common Stock, cash or other property that becomes subject to the Award pursuant to this Section 1
shall be subject, in a manner determined by the Board, to the same forfeiture restrictions, restrictions on transferability, and time and manner of delivery as applicable to the other Stock Units and Common Stock covered by your Award. 

Notwithstanding the provisions of this Section 1, no fractional Stock Units or rights for fractional shares of Common Stock shall be
created pursuant to this Section 1. The Board shall, in its discretion, determine an equivalent benefit for any fractional Stock Units or fractional shares that might be created by the adjustments referred to in this Section 1. 

VESTING. The Stock Units shall vest, if at all, as provided in the Vesting Schedule set forth in your
Grant Notice and the Plan, provided that vesting shall cease upon the termination of your Continuous Service. 
 DELIVERY
OF SHARES OF COMMON STOCK. 
 Subject to the
provisions of this Agreement and the Plan, in the event one or more Stock Units vests, the Company shall deliver to you one (1) share of Common Stock for each Stock Unit that vests on the applicable vesting date. However, if a scheduled
delivery date falls on a date that is not a business day, such delivery date shall instead fall on the next following business day. Notwithstanding the foregoing, in the event that (i) any shares covered by your Award are scheduled to be
delivered on a day (the “Original Distribution Date”) on which you are prohibited from selling shares of Common Stock on the open market as a result of the Company’s policy permitting officers and directors to sell
shares only during certain “window periods” in effect from time to time (the “Policy”) or otherwise, (ii) you are not permitted to satisfy the Withholding Taxes by selling shares of Common Stock pursuant to a
written plan that meets the requirements of Rule 10b5-1 under the Exchange Act, (iii) the Company elects not to satisfy the Withholding Taxes by withholding shares from your distribution, and (iv) you have not tendered a cash payment to
the Company to satisfy the Withholding Taxes, then such shares shall not be delivered on such Original Distribution Date and shall instead be delivered on the first business day of the next occurring open “window period” applicable to you
pursuant to the Policy (regardless of whether you are still providing Continuous Service at such time) or the next business day when you are not prohibited from selling shares of Common Stock on the open market, but in no event later than the
fifteenth (15th) day of the third calendar month of the calendar year following the calendar year in which the shares covered by the Award vest. Delivery of the shares pursuant to the provisions of this Section 3(a) is intended to comply
with the requirements for the short-term deferral exemption available under Treasury Regulations Section 1.409A-1(b)(4) and shall be construed and administered in such manner. 

The form of such delivery (e.g., a stock certificate or electronic entry evidencing such shares) shall be determined by the Company.

 PAYMENT BY YOU. This Award was
granted in consideration of your services for the Company. Subject to Section 10 below, except as otherwise provided in the Grant Notice, you will not be required to make any payment to the Company (other than your past and future services for
the Company) with respect to your receipt of the Award, vesting of the Stock Units, or the delivery of the shares of Common Stock underlying the Stock Units. 

SECURITIES LAW COMPLIANCE. You may not be issued any Common Stock under
your Award unless either (i) the shares of Common Stock are then registered under the Securities Act of 1933, as amended (the “Securities Act”) or (ii) the Company has determined that such issuance would be exempt
from the registration requirements of the Securities Act. Your Award must also comply with other applicable laws and regulations governing the Award, and you shall not receive such Common Stock if the Company determines that such receipt would not
be in material compliance with such laws and regulations. 
 RESTRICTIVE LEGENDS. The Common Stock
issued under your Award shall be endorsed with appropriate legends, if any, determined by the Company. 
 TRANSFER
RESTRICTIONS. Prior to the time that shares of Common Stock have been delivered to you, you may not transfer, pledge, sell or otherwise dispose of the shares in respect of your Award. For example, you may not use shares that may
be issued in respect of your Stock Units as security for a loan, nor may you transfer, pledge, sell or otherwise dispose of such shares. This restriction on transfer will lapse upon delivery to you of shares in respect of your vested Stock Units.
Your Award is not transferable, except by will or by the laws of descent and distribution. Notwithstanding the foregoing, by delivering written notice to the Company, in a form satisfactory to the Company, you may designate a third party who, in the
event of your death, shall thereafter be entitled to receive any distribution of Common Stock to which you were entitled at the time of your death pursuant to this Agreement. 

AWARD NOT A SERVICE CONTRACT. Your Award is
not an employment or service contract, and nothing in your Award shall be deemed to create in any way whatsoever any obligation on your part to continue in the service of the Company or any Affiliate, or on the part of the Company or any Affiliate
to continue such service. In addition, nothing in your Award shall obligate the Company or any Affiliate, their respective stockholders, boards of directors or employees to continue any relationship that you might have as an Employee or Consultant
of the Company or any Affiliate. 
 UNSECURED OBLIGATION. Your Award is unfunded, and
even as to any Stock Units that vest, you shall be considered an unsecured creditor of the Company with respect to the Company’s obligation, if any, to issue Common Stock pursuant to this Agreement. You shall not have voting or any other rights
as a stockholder of the Company with respect to the Common Stock acquired pursuant to this Agreement until such Common Stock is issued to you pursuant to Section 3 of this Agreement. Upon such issuance, you will obtain full voting and other
rights as a stockholder of the Company with respect to the Common Stock so issued. Nothing contained in this Agreement, and no action taken pursuant to its provisions, shall create or be construed to create a trust of any kind or a fiduciary
relationship between you and the Company or any other person. 
 WITHHOLDING OBLIGATIONS. 

On or before the time you receive a distribution of Common Stock pursuant to your Award, or at any time thereafter as requested by the Company,
you hereby agree to make adequate provision for any sums required to satisfy the federal, state, local and foreign income and employment tax withholding obligations of the Company or any Affiliate which arise in connection with your Award (the
“Withholding Taxes”). The Company may, in its sole discretion, satisfy all or any portion of the Withholding Taxes relating to your Award by any of the following means or by a combination of such means: 

withholding shares of Common Stock from the shares of Common Stock otherwise issuable to you in connection with your Award with a Fair Market
Value (measured as of the date shares of Common Stock are delivered pursuant to Section 3) equal to the amount of such Withholding Taxes; provided, however, that the number of such shares of Common Stock so withheld shall not exceed the
amount necessary to satisfy the Company’s required tax withholding obligations using the minimum statutory withholding rates for federal, state, local and foreign tax purposes, including payroll taxes, that are applicable to supplemental
taxable income; 
 withholding from any compensation otherwise payable to you by the Company or an Affiliate; 

causing you to tender a cash payment; or 

permitting you to enter into a “same day sale” commitment with a broker-dealer that is a member of the Financial Industry
Regulatory Authority (a “FINRA Dealer”) whereby you irrevocably elect to sell a portion of the shares to be 

 delivered in connection with your Award to satisfy the Withholding Taxes and whereby the FINRA Dealer irrevocably
commits to forward the proceeds necessary to satisfy the Withholding Taxes directly to the Company and/or its Affiliates. 
 Unless the tax
withholding obligations of the Company and/or any Affiliate are satisfied, the Company shall have no obligation to deliver to you any Common Stock. 

In the event the Company’s obligation to withhold arises prior to the delivery to you of Common Stock or it is determined after the
delivery of Common Stock to you that the amount of the Company’s withholding obligation was greater than the amount withheld by the Company, you agree to indemnify and hold the Company harmless from any failure by the Company to withhold the
proper amount. 
 CHANGE IN CONTROL. 

If your Continuous Service terminates within twelve (12) months following the effective date of a Change in Control due to (i) an
involuntary termination (excluding death or Disability) without Cause, or (ii) a voluntary termination for Good Reason, the vesting of your Award shall be accelerated in full. 

“Cause,” “Change in Control,” “Continuous Service” and “Disability” shall have the respective meanings
set forth in the Plan. 
 “Good Reason” means that one or more of the following are undertaken by the Company without your express
written consent: (i) the assignment to you of any duties or responsibilities that results in a material diminution in your function as in effect immediately prior to the effective date of the Change in Control; provided, however, that
neither a change in your title or reporting relationships nor the Common Stock ceasing to be listed on any established stock exchange or traded on the Nasdaq Global Market or the Nasdaq Capital Market shall provide the basis for a voluntary
termination with Good Reason; (ii) a material reduction by the Company in your annual base salary, as in effect on the effective date of the Change in Control or as increased thereafter; provided, however, that Good Reason shall not be
deemed to have occurred in the event of a reduction in your annual base salary that is pursuant to a salary reduction program affecting substantially all of the employees of the Company and that does not adversely affect you to a greater extent than
other similarly situated employees; (iii) any failure by the Company to continue in effect any material benefit plan or program, including incentive plans or plans with respect to the receipt of securities of the Company, in which you were
participating immediately prior to the effective date of the Change in Control (hereinafter referred to as “Benefit Plans”), or the taking of any action by the Company that would materially adversely affect your participation
in or materially reduce your benefits under the Benefit Plans or deprive you of any material fringe benefit that you enjoyed immediately prior to the effective date of the Change in Control; provided, however, that Good Reason shall not be
deemed to have occurred if the Company provides for your participation in benefit plans and programs that, taken as a whole, are comparable to the Benefit Plans; (iv) a relocation of your business office to a location more than fifty
(50) miles from the location at which you performed your duties as of the effective date of the Change in Control, except for required travel by you on the Company’s business to an extent substantially consistent with your business travel
obligations prior to the effective date of the Change in Control; or (v) a material breach by the Company of any provision of the Plan or this Agreement or any other material agreement between you and the Company concerning the terms and
conditions of your employment. 
 BEST AFTER-TAX PROVISION. 

If any payment or benefit you would receive pursuant to a Change in Control from the Company or otherwise (“Payment”)
would (i) constitute a “parachute payment” within the meaning of Section 280G of the Code, and (ii) but for this sentence, be subject to the excise tax imposed by Section 4999 of the Code (the “Excise
Tax”), then such Payment shall be equal to the Reduced Amount. The “Reduced Amount” shall be either (x) the largest portion of the Payment that would result in no portion of the Payment being subject to the Excise Tax, or
(y) the largest portion, up to and including the total, of the Payment, whichever amount, after taking into account all applicable federal, state and local employment taxes, income taxes, and the Excise Tax (all computed at the highest
applicable marginal rate), results in your receipt, on an after-tax basis, of the greater amount of the Payment notwithstanding that all or some portion of the Payment may be subject to the Excise Tax. If a reduction in payments or benefits
constituting “parachute payments” is necessary so that the Payment equals the Reduced Amount, reduction shall occur in a manner necessary to provide you with the greatest economic benefit. If more than one manner of reduction of payments
or benefits necessary to arrive at the Reduced Amount yields the greatest economic benefit, the payments and benefits shall be reduced pro rata. 

The accounting firm engaged by the Company for general tax purposes as of the day prior to the effective date of the Change in Control shall
perform the foregoing calculations. If the accounting firm so engaged by the Company is serving as accountant or auditor for the individual, entity or group effecting the Change in Control, the Company shall appoint a nationally

 
recognized accounting firm to make the determinations required hereunder. The Company shall bear all expenses with respect to the determinations by such accounting firm required to be made
hereunder. 
 The accounting firm engaged to make the determinations hereunder shall provide its calculations, together with detailed
supporting documentation, to you and the Company within fifteen (15) calendar days after the date on which your right to a Payment is triggered (if requested at that time by you or the Company) or such other time as requested by you or the
Company. If the accounting firm determines that no Excise Tax is payable with respect to a Payment, either before or after the application of the Reduced Amount, it shall furnish you and the Company with an opinion reasonably acceptable to you that
no Excise Tax will be imposed with respect to such Payment. Any good faith determinations of the accounting firm made hereunder shall be final, binding and conclusive upon you and the Company. 

NOTICES. Any notices provided for in your Award or the Plan shall be given in writing to each of the other
parties hereto and shall be deemed effectively given on the earlier of (i) the date of personal delivery, including delivery by express courier, or (ii) the date that is five (5) days after deposit in the United States Post Office
(whether or not actually received by the addressee), by registered or certified mail with postage and fees prepaid, addressed at the following addresses, or at such other address(es) as a party may designate by ten (10) days’ advance
written notice to each of the other parties hereto: 
  

			
	 COMPANY:
	  	XenoPort, Inc.
		  	Attn: General Counsel
		  	3410 Central Expressway
		  	Santa Clara, California 95051
		
	 PARTICIPANT:
	  	Your address as on file with the Company at the time notice is given

 HEADINGS. The headings of the Sections in this Agreement are inserted for
convenience only and shall not be deemed to constitute a part of this Agreement or to affect the meaning of this Agreement. 

AMENDMENT. This Agreement may be amended only by a writing executed by the Company and you which specifically states
that it is amending this Agreement. Notwithstanding the foregoing, this Agreement may be amended solely by the Company by a writing which specifically states that it is amending this Agreement, so long as a copy of such amendment is delivered to
you, and provided that no such amendment adversely affecting your rights hereunder may be made without your written consent. Without limiting the foregoing, the Company reserves the right to change, by written notice to you, the provisions of this
Agreement in any way it may deem necessary or advisable to carry out the purpose of the grant as a result of any change in applicable laws or regulations or any future law, regulation, ruling, or judicial decision, provided that any such change
shall be applicable only to rights relating to that portion of the Award that has not been delivered to you in Common Stock pursuant to Section 3. 

MISCELLANEOUS. 

The rights and obligations of the Company under your Award shall be transferable by the Company to any one or more persons or entities, and all
covenants and agreements hereunder shall inure to the benefit of, and be enforceable by the Company’s successors and assigns. 
 You
agree upon request to execute any further documents or instruments necessary or desirable in the sole determination of the Company to carry out the purposes or intent of your Award. 

You acknowledge and agree that you have reviewed your Award in its entirety, have had an opportunity to obtain the advice of counsel prior to
executing and accepting your Award and fully understand all provisions of your Award. 
 This Agreement shall be subject to all applicable
laws, rules, and regulations, and to such approvals by any governmental agencies or national securities exchanges as may be required. 
 All
obligations of the Company under the Plan and this Agreement shall be binding on any successor to the Company, whether the existence of such successor is the result of a direct or indirect purchase, merger, consolidation, or otherwise, of all or
substantially all of the business and/or assets of the Company. 
 GOVERNING PLAN
DOCUMENT. Your Award is subject to all the provisions of the Plan, the provisions of which are hereby made a part of your Award, and is further subject to all interpretations, amendments, rules and regulations which
may from time to time be promulgated and adopted pursuant to the Plan. In the event of any conflict between the provisions of your Award and those of 

 
the Plan, the provisions of the Plan shall control; provided, however, that Section 3 of this Agreement shall govern the timing of any distribution of Common Stock under your Award.
The Company shall have the power to interpret the Plan and this Agreement and to adopt such rules for the administration, interpretation, and application of the Plan as are consistent therewith and to interpret or revoke any such rules. All actions
taken and all interpretations and determinations made by the Board shall be final and binding upon you, the Company, and all other interested persons. No member of the Board shall be personally liable for any action, determination, or interpretation
made in good faith with respect to the Plan or this Agreement. 
 EFFECT ON OTHER
EMPLOYEE BENEFIT PLANS. The value of the Award subject to this Agreement shall not be included as compensation, earnings, salaries, or other similar terms used when calculating benefits under any
employee benefit plan (other than the Plan) sponsored by the Company or any Affiliate except as such plan otherwise expressly provides. The Company expressly reserves its rights to amend, modify, or terminate any or all of the employee benefit plans
of the Company or any Affiliate. 
 CHOICE OF LAW. The interpretation, performance and
enforcement of this Agreement shall be governed by the law of the state of California without regard to such state’s conflicts of laws rules. 

SEVERABILITY. If all or any part of this Agreement or the Plan is declared by any court or governmental
authority to be unlawful or invalid, such unlawfulness or invalidity shall not invalidate any portion of this Agreement or the Plan not declared to be unlawful or invalid. Any Section of this Agreement (or part of such a Section) so declared to be
unlawful or invalid shall, if possible, be construed in a manner which will give effect to the terms of such Section or part of a Section to the fullest extent possible while remaining lawful and valid. 

OTHER DOCUMENTS. You hereby acknowledge receipt or the right to receive a document
providing the information required by Rule 428(b)(1) promulgated under the Securities Act (which includes the prospectus for this Award). In addition, you acknowledge receipt of the Company’s Policy Regarding Stock Trading by Directors,
Officers and Other Designated Insiders. 
 * * * * * 

This Restricted Stock Unit Award Agreement shall be deemed to be signed by the Company and you upon your electronic signing of the Restricted
Stock Unit Grant Notice to which it is attached.

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