Document:

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                                                                    EXHIBIT 10.1
                                                                    ------------

                                                               December 16, 2005

Mr. Ronald C. Newbold
20 Hillcrest Road
Martinsville, New Jersey 08836

    Re: Separation from Sentigen Holding Corp.
        --------------------------------------

Dear Ron:

         In connection with the termination without cause, effective January 11,
2006, of your employment with Sentigen Holding Corp. (the "Company"), this
letter will confirm our following agreement:

         1. Your employment with the Company will terminate on January 11, 2006
(the "Termination Date") pursuant to Section 11(d) of your Employment Agreement
with the Company dated as of January 3, 2005 (the "Employment Agreement"). Your
Employment Agreement will be terminated as of the Termination Date and will be
of no further force and effect, except that Sections 8, 9 and 10 of the
Employment Agreement shall survive the termination of your employment with the
Company and remain in full force and effect. You hereby resign as Executive Vice
President, Commercial Operations, of the Company effective at the Termination
Date.

         2. You will continue to be paid your annual base salary of $205,000 now
in effect through the Termination Date and for a period of six months
thereafter, less withholding requirements required by law or agreed to by you,
payable in installments at such times as the Company customarily pays its other
senior officers (but in any event no less often then monthly) for so long as
your are in compliance with the terms of this Agreement and Sections 8, 9 and 10
of the Employment Agreement.

         3. You will be paid for any accrued but unused 2006 vacation time
through the Termination Date.

         4. You will be paid your $25,000 minimum 2005 bonus on December 30,
2005.

         5. For so long as your are in compliance with the terms of this
Agreement and Sections 8, 9 and 10 of the Employment Agreement, you will
continue to receive any employee benefits you were receiving at the Termination
Date through the Termination Date and for a period of six months thereafter, to
the extent such benefits continue to remain available to employees of the
Company, including but not limited to, participation in the Company's 401(k)
plan, dental, major medical and any other health insurance that was in place as
of the Termination Date, provided, however, that to the extent the Company
changes its health care provider after the Termination Date, you shall be
entitled to receive health care benefits for such new health care provider for
the period set forth above.

         6. Your stock options to purchase 12,500 shares scheduled to vest on
January 3, 2006,
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granted to you pursuant to the Company's 2000 Performance Equity Plan shall vest
as scheduled on such date. Your stock options to purchase 12,500 shares
scheduled to vest on January 3, 2007, granted to you pursuant to the Company's
2000 Performance Equity Plan shall immediately become vested as of the
Termination Date. Your stock options to purchase 25,000 shares scheduled to vest
with respect to 12,500 shares on each of January 3, 2008 and January 3, 2009,
granted to you pursuant to the Company's 2000 Performance Equity Plan shall be
terminated effective as of the Termination Date.

         7. In consideration of the foregoing as provided for in Section 11(d)
of the Employment Agreement, you agree that the payments set forth above are
given to you in return for your discharge and release of all claims,
obligations, and demands which you have, ever had, or in the future may have
against the Company, Sentigen Biosciences, Inc., Cell & Molecular Technologies,
Inc. and any of their officers, directors, employees, or agents, arising up to
the date of this Release, including, but not limited to, claims under Title VII
of the Civil Rights Act of 1964, the Fair Labor Standards Act, the New York
Executive Law, the Administrative Code of the City of New York, the New Jersey
Law Against Discrimination, the Civil Rights Act of 1991, the Age Discrimination
in Employment Act, the Older Workers Benefits Protection Act, the Employee
Retirement Income Security Act of 1974, the Americans With Disabilities Act, and
all other federal, state, and local discrimination laws, and claims for wrongful
discharge. You further waive and release any claimed right to reemployment, or
employment in the future with the Company, Sentigen Biosciences, Inc. or Cell &
Molecular Technologies, Inc. You do not, however, waive or release any claims
which arise after the date that you execute this agreement.

         8. The Company has advised you to consult with an attorney and/or
governmental agencies prior to executing this agreement. By executing this
agreement you acknowledge that you have been provided an opportunity to consult
with an attorney or other advisor of your choice regarding the terms of this
agreement, that you have been given a minimum of twenty-one days in which to
consider whether you wish to enter into this agreement, and that you have
elected to enter into this agreement knowingly and voluntarily. You may revoke
your assent to this agreement within seven days of its execution by you (the
"Revocation Period"), and the agreement will not become effective or enforceable
until the Revocation Period has expired.

         9. You agree to act in good faith toward the Company and its affiliates
so as not to harm the business of the Company or its affiliates in any way,
which obligations shall include, but not be limited to, your promise that you
will not in any way, either directly or through other persons or entities,
disparage or otherwise criticize the services, products, operations, prospects,
business, strategy, integrity, truthfulness, reputation or other matters
relating to the Company's businesses or any of the Company's affiliates,
employees, officers, partners, managers or directors. The Company agrees to act
in good faith toward you so as not to harm you in any way, which obligations
shall include, but not be limited to, the Company's promise that it will not in
any way, directly or through other persons or entities, disparage or otherwise
criticize your services, business, integrity, truthfulness or reputation. You
further agree that you shall not, in anyway, interfere with the Company or any
of its affiliates' relationships with any of its current or prospective
customers, clients, partners, consultants or other parties doing business with
the Company from time to time.
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         Please confirm your acceptance of the terms of this letter by signing
and dating it and returning it to us.

                                       Very truly yours,

                                       SENTIGEN HOLDING CORP.

                                       By: /s/ Fredrick B. Rolff
                                           ------------------------------
                                           Name:  Fredrick B. Rolff
                                           Title: Chief Financial Officer

ACCEPTED AND AGREED TO:

/s/ Ronald C. Newbold
------------------------
Ronald C. Newbold

Date: December 16, 2005<PAGE>
                                                                    Exhibit 10.1

                           REPLACEMENT REVOLVING NOTE

$5,000,000                                            Dated as of August 1, 2005
                                                             Due: August 1, 2006

     FOR VALUE RECEIVED, COMMUNITY SHORES BANK CORPORATION, a Michigan
corporation (the "Maker"), promises to pay to the order of LASALLE BANK NATIONAL
ASSOCIATION (the "Bank") the lesser of the principal sum of Five Million Dollars
($5,000,000) or the aggregate unpaid principal amount outstanding under the
Agreement (as hereinafter defined) made available by the Bank to the Maker at
the maturity or maturities and in the amount or amounts as stated on the records
of the Bank together with interest (computed on actual days elapsed on the basis
of a 360 day year) on any and all principal amounts outstanding hereunder from
time to time from the date hereof until maturity. Interest shall be payable at
the rate of interest and the times set forth in the Revolving Loan Agreement
dated as of July 23, 2004 between Maker and the Bank, as amended from time to
time (the "Agreement"). In no event shall any principal amount have a maturity
later than August 1, 2006.

     This Replacement Revolving Note ("Note") shall be available for direct
advances.

     Principal and interest shall be paid to the Bank at its office at 135 South
LaSalle Street, Chicago, Illinois 60603, or at such other place as the holder of
this Note may designate in writing to the undersigned. This Note may be prepaid
in whole or in part as provided for in the Loan Agreement.

     This Note evidences indebtedness incurred under the Agreement to which
reference is hereby made for a statement of the terms and conditions under which
the due date of the Note or any payment thereon may be accelerated. The holder
of this Note is entitled to all of the benefits and security provided for in the
Agreement.

     The undersigned agrees that in any action or proceeding instituted to
collect or enforce collection of this Note, the amount endorsed by the Bank on
the reverse side of this Note shall be prima facie evidence of the unpaid
principal balance of this Note.

     This Note is in substitution and replacement for, but not a repayment of,
that certain $5,000,000 Revolving Credit Note dated as of July 23, 2004 of the
Maker payable to the order of the Bank, and does not and shall not be deemed to
constitute a novation therefor.

     IN WITNESS WHEREOF, the Maker has executed this Replacement Revolving Note
as of the date set forth above.

                                        COMMUNITY SHORES BANK CORPORATION,
                                        a Michigan corporation

                                        By:
                                            ------------------------------------
                                        Its:
                                             -----------------------------------

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