Document:

Amended and Restate 2002 Stock Option and Incentive Plan

 Exhibit 10.1 
 ORAGENICS, INC. 
 2002 STOCK OPTION AND INCENTIVE PLAN 
 As Amended on February 23, 2005 
 TABLE OF CONTENTS 
  

					
	 ARTICLE 1
	  	DEFINITIONS	  	39
			
	 ARTICLE 2
	  	THE PLAN	  	43
			
	         2.1
	  	NAME	  	43
	         2.2
	  	PURPOSE	  	43
	         2.3
	  	EFFECTIVE DATE	  	43
			
	 ARTICLE 3
	  	PARTICIPANTS	  	43
			
	 ARTICLE 4
	  	ADMINISTRATION	  	44
			
	         4.1
	  	DUTIES AND POWERS OF THE COMMITTEE	  	44
	         4.2
	  	INTERPRETATION; RULES	  	44
	         4.3
	  	NO LIABILITY	  	45
	         4.4
	  	MAJORITY RULE	  	45
	         4.5
	  	COMPANY ASSISTANCE	  	45
			
	 ARTICLE 5
	  	SHARES OF STOCK SUBJECT TO PLAN	  	45
			
	         5.1
	  	LIMITATIONS	  	45
	         5.2
	  	ADJUSTMENTS UPON OCCURRENCE OF CERTAIN EVENTS	  	46
			
	 ARTICLE 6
	  	OPTIONS	  	47
			
	         6.1
	  	TYPES OF OPTIONS GRANTED	  	47
	         6.2
	  	OPTION GRANT AND AGREEMENT	  	47
	         6.3
	  	OPTIONEE LIMITATIONS	  	47
	         6.4
	  	$100,000 AND SECTION 162(M) LIMITATIONS	  	48
	         6.5
	  	EXERCISE PRICE	  	48
	         6.6
	  	EXERCISE PERIOD	  	48
	         6.7
	  	OPTION EXERCISE	  	48
	         6.8
	  	NONTRANSFERABILITY OF OPTION	  	50
	         6.9
	  	TERMINATION OF EMPLOYMENT OR SERVICE	  	50
	         6.10
	  	EMPLOYMENT RIGHTS	  	50
	         6.11
	  	CERTAIN SUCCESSOR OPTIONS	  	50

  

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	         6.12
	 	OTHER RESTRICTIONS	  	50
			
	 ARTICLE 7
	 	RESTRICTED STOCK	  	51
			
	         7.1
	 	AWARDS OF RESTRICTED STOCK	  	51
	         7.2
	 	NON-TRANSFERABILITY	  	51
	         7.3
	 	LAPSE OF RESTRICTIONS	  	52
	         7.4
	 	TERMINATION OF EMPLOYMENT	  	52
	         7.5
	 	TREATMENT OF DIVIDENDS	  	52
	         7.6
	 	DELIVERY OF SHARES	  	52
			
	 ARTICLE 8
	 	STOCK APPRECIATION RIGHTS	  	52
			
	         8.1
	 	SAR GRANTS	  	52
	         8.2
	 	DETERMINATION OF PRICE	  	52
	         8.3
	 	EXERCISE OF A SAR	  	53
	         8.4
	 	PAYMENT FOR A SAR	  	53
	         8.5
	 	STATUS OF A SAR UNDER THE PLAN	  	53
	         8.6
	 	TERMINATION OF SARS	  	53
	         8.7
	 	NO SHAREHOLDER RIGHTS	  	54
	         8.8
	 	SARS GRANTED IN TANDEM WITH INCENTIVE STOCK OPTIONS	  	54
			
	 ARTICLE 9
	 	STOCK CERTIFICATES	  	54
			
	 ARTICLE 10
	 	TERMINATION AND AMENDMENT	  	55
			
	         10.1
	 	TERMINATION AND AMENDMENT	  	55
	         10.2
	 	EFFECT ON GRANTEE’S RIGHTS	  	55
			
	 ARTICLE 11
	 	RELATIONSHIP TO OTHER COMPENSATION PLANS	  	55
			
	 ARTICLE 12
	 	MISCELLANEOUS	  	55
			
	         12.1
	 	REPLACEMENT OR AMENDED GRANTS	  	55
	         12.3
	 	LEAVE OF ABSENCE	  	56
	         12.4
	 	PLAN BINDING ON SUCCESSORS	  	56
	         12.5
	 	SINGULAR, PLURAL; GENDER	  	56
	         12.6
	 	HEADINGS, ETC.	  	56
	         12.7
	 	SECTION 16 COMPLIANCE	  	56
		
	 EXHIBIT A TO ORAGENICS, INC. 2002 STOCK OPTION AND INCENTIVE PLAN
	  	A-1

  

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 ORAGENICS, INC. 
 2002 STOCK OPTION AND INCENTIVE PLAN 
 ARTICLE 1 
 DEFINITIONS 
 As used in this Plan, the following terms have the following meanings unless the
context clearly indicates to the contrary: 
 “Award” means a grant of Restricted Stock or an SAR. 
 “Board” means the Board of Directors of the Company. 
 “Cause” means (i) the commission of an act of fraud, embezzlement, theft or proven dishonesty, or any other illegal act or practice (whether or not resulting in criminal prosecution or
conviction), including theft or destruction of property of the Company, a Parent, or a Subsidiary, or any other act or practice which the Committee shall, in good faith, deem to have resulted in the recipient’s becoming unbondable under the
Company’s, a Parent’s or any Subsidiary’s fidelity bond; (ii) the willful engaging in misconduct which is deemed by the Committee, in good faith, to be materially injurious to the Company, a Parent or any Subsidiary, monetarily
or otherwise, including, but not limited to, improperly disclosing trade secrets or other confidential or sensitive business information and data about the Company, a Parent or any Subsidiaries and competing with the Company, a Parent or any
Subsidiaries, or soliciting employees, consultants or customers of the Company, a Parent or any Subsidiaries in violation of law or any employment or other agreement to which the recipient is a party; (iii) the continued failure or habitual
neglect by a person who is an Employee to perform his or her duties with the Company, a Parent or any Subsidiary; or (iv) other disregard of rules or policies of the Company, a Parent or any Subsidiary, or conduct evidencing willful or wanton
disregard of the interests of the Company, a Parent or any Subsidiary. For purposes of this Plan, no act or failure to act by the recipient shall be deemed “willful” unless done or omitted to be done by the recipient not in good faith and
without reasonable belief that the recipient’s action or omission was in the best interest of the Company and/or the Subsidiary. Notwithstanding the foregoing, if the recipient has entered into an employment agreement that is binding as of the
date of employment termination, and if such employment agreement defines “Cause,” then the definition of “Cause” in such agreement shall apply to the recipient in this Plan. “Cause” shall be determined by the Committee
based upon information presented by the Company and the Employee and shall be final and binding on all parties hereto. 
 “Code” means the United States Internal Revenue Code of 1986, including effective date and transition rules (whether or not codified). Any reference herein to a specific section of the Code shall be deemed to include a
reference to any corresponding provision of future law. 
  

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 “Committee” means the Compensation Committee that is comprised of at least two Directors
appointed from time to time by the Board, having the duties and authority set forth herein in addition to any other authority granted by the Board; provided, however, that with respect to any Options or Awards granted to an individual who is also a
Section 16 Insider, the Committee shall consist of either the entire Board of Directors or a committee of at least two Directors (who need not be members of the Committee with respect to Options or Awards granted to any other individuals) who
are Non-Employee Directors, and all authority and discretion shall be exercised by such Non-Employee Directors, and references herein to the “Committee” means such Non-Employee Directors insofar as any actions or determinations of the
Committee shall relate to or affect Options or Awards made to or held by any Section 16 Insider. In selecting the Committee, the Board shall also consider the benefits under Section 162(m) of the Code of having a Committee composed of
“outside directors” (as that term is defined in the Code) for certain grants of Options to highly compensated executives. At any time that the Board shall not have appointed a committee as described above, any reference herein to the
Committee means a reference to the Board. 
 “Company” means Oragenics, Inc., a Florida corporation. 
 “Corporate Transaction” means any of the following transactions to which the Company is a party: 
  

	 	(i)	a merger, consolidation, share exchange, combination or other transaction or series of transactions (other than a public offering by the Company for cash of the Company’s
capital stock, debt or other securities, and other than ordinary public trading of such securities) in which securities possessing more than 50% of the total combined voting power of the Company’s outstanding securities are transferred to a
person or persons different from the persons holding those securities immediately prior to such transaction; 

  

	 	(ii)	the sale, transfer or other disposition of all or substantially all of the Company’s assets; or 

  

	 	(iii)	a change in the composition of the Board as a result of which fewer than one-half of the incumbent directors are directors who either: 

  

	 	(a)	had been directors of the Company 24 months prior to such change; or 

  

	 	(b)	were elected, or nominated for election, to the Board with the affirmative votes of at least a majority of the directors who had been directors of the Company 24 months prior to
such change and who were still in office at the time of the election or nomination. 

  

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 “Director” means a member of the Board and any person who is an advisory or honorary
director of the Company if such person is considered a director for the purposes of Section 16 of the Exchange Act, as determined by reference to such Section 16 and to the rules, regulations, judicial decisions, and interpretative or
“no-action” positions with respect thereto of the SEC, as the same may be in effect or set forth from time to time. 
 “Employee” means an employee (as defined in Section 3401(c) of the Code and the regulations promulgated thereunder) of the Company or a Parent or Subsidiary. 
 “Exchange Act” means the Securities Exchange Act of 1934. Any reference herein to a specific section of the Exchange Act shall be deemed
to include a reference to any corresponding provision of future law. 
 “Exercise Price” means the price at which an
Optionee may purchase a share of Stock under a Stock Option Agreement. 
 “Fair Market Value” on any date means (i) the
closing sales price of the Stock, regular way, on such date on the national securities exchange having the greatest volume of trading in the Stock during the thirty-day period preceding the day the value is to be determined or, if such exchange was
not open for trading on such date, the next preceding date on which it was open; (ii) if the Stock is not traded on any national securities exchange, the average of the closing high bid and low asked prices of the Stock on the over-the-counter
market on the day such value is to be determined, or in the absence of closing bids on such day, the closing bids on the next preceding day on which there were bids; or (iii) if the Stock also is not traded on the over-the-counter market, the
fair market value as determined in good faith by the Board or the Committee based on such relevant facts as may be available to the Board, which may include opinions of independent experts, the price at which recent sales have been made, the book
value of the Stock, and the Company’s current and anticipated future earnings. 
 “Grantee” means a person who is an
Optionee or a person who has received an Award of Restricted Stock or a SAR. 
 “Incentive Stock Option” means an option to
purchase any stock of the Company, which complies with and is subject to the terms, limitations and conditions of Section 422 of the Code and any regulations promulgated with respect thereto. 
 “Non-Employee Director” shall have the meaning set forth in Rule 16b-3 under the Exchange Act, as the same may be in effect from time to
time, or in any successor rule thereto, and shall be determined for all purposes under the Plan according to interpretative or “no-action” positions with respect thereto issued by the SEC. 
  

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 “Officer” means a person who constitutes an officer of the Company for the purposes of
Section 16 of the Exchange Act, as determined by reference to such Section 16 and to the rules, regulations, judicial decisions, and interpretative or “no-action” positions with respect to such rule of the SEC, as the same may be
in effect or set forth from time to time. 
 “Option” means an option, whether or not an Incentive Stock Option, to purchase
Stock granted pursuant to the provisions of Article 6 of this Plan. 
 “Optionee” means a person to whom an Option has been
granted under this Plan. 
 “Parent” means any corporation (other than the Company) in an unbroken chain of corporations
ending with the Company if, at the time of the grant (or modification) of the Option, each of the corporations other than the Company owns stock possessing 50 percent or more of the total combined voting power of the classes of stock in one of the
other corporations in such chain. 
 “Plan” means the Company’s 2002 Stock Option and Incentive Plan, the terms of
which are set forth herein. 
 “Purchasable” refers to Stock which may be purchased by an Optionee under the terms of this
Plan on or after a certain date specified in the applicable Stock Option Agreement. 
 “Qualified Domestic Relations Order”
has the meaning set forth in the Code or in the Employee Retirement Income Security Act of 1974, or the rules and regulations promulgated under the Code or such Act. 
 “Restricted Stock” means Stock issued, subject to restrictions, to a Grantee pursuant to Article 7 of this Plan. 
 “Restriction Agreement” means the agreement setting forth the terms of an Award, and executed by a Grantee as provided in Section 7.1 of this Plan. 
 “SAR” means a stock appreciation right, which is the right to receive an amount equal to the appreciation, if any, in the Fair Market
Value of a share of Stock from the date of the grant of the right to the date of its payment, all as provided in Article 8 of this Plan. 
 “SAR Price” means the base value established by the Committee for a SAR on the date the SAR is granted and which is used in determining the amount of benefit, if any, paid to a Grantee. 
 “SEC” means the United States Securities and Exchange Commission. 
 “Section 16 Insider” means any person who is subject to the provisions of Section 16 of the Exchange Act, as provided in Rule 16a-2
promulgated pursuant to the Exchange Act. 
  

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 “Stock” means the Common Stock, $.001 par value per share, of the Company or, in the
event that the outstanding shares of Stock are hereafter changed into or exchanged for shares of a different stock or securities of the Company or some other entity, such other stock or securities. 
 “Stock Option Agreement” means an agreement between the Company and an Optionee under which the Optionee may purchase Stock under this
Plan, a sample form of which is attached hereto as Exhibit A (which form may be varied by the Committee in granting an Option). 
 “Subsidiary” means any corporation (other than the Company) in an unbroken chain of corporations beginning with the Company if, at the time of the grant (or modification) of the Option, each of the corporations other than
the last corporation in the unbroken chain owns stock possessing 50 percent or more of the total combined voting power of all classes of stock in one of the other corporations in such chain. 
 ARTICLE 2 
 THE PLAN 
 2.1 Name. This Plan shall be known as the Company’s “2002 Stock Option and Incentive Plan.” 
 2.2 Purpose. The purpose of the Plan is to advance the interests of the Company, its Subsidiaries and its shareholders by affording certain
Employees and Directors of the Company and its Subsidiaries, as well as key consultants to the Company or any Subsidiary, an opportunity to acquire or increase their proprietary interests in the Company. The objective of the issuance of the Options
and Awards is to promote the growth and profitability of the Company and its Subsidiaries because the Grantees will be provided with an additional incentive to achieve the Company’s objectives through participation in its success and growth and
by encouraging their continued association with or service to the Company. 
 2.3 Effective Date. The Plan shall become effective on
the date it is adopted by the Board; provided, however, that if the Company’s shareholders have not approved the Plan on or prior to the first anniversary of such effective date, then all options granted under the Plan shall be non-Incentive
Stock Options. 
 ARTICLE 3 
 PARTICIPANTS 
 The class of persons eligible to participate in the Plan shall consist of all persons whose participation
in the Plan the Committee determines to be in the best interests of the Company, provided all participants shall be bona fide Employees or Directors of the Company or any Subsidiary, or bona fide consultants to the Company or any Subsidiary.

  

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 ARTICLE 4 
 ADMINISTRATION 
 4.1 Duties and Powers of the Committee. The Plan shall be administered by the
Committee. The Committee shall select one of its members as its Chairman and shall hold its meetings at such times and places as it may determine. The Committee shall keep minutes of its meetings and shall make such rules and regulations for the
conduct of its business as it may deem necessary. The Committee shall have the power to act by unanimous written consent in lieu of a meeting, and to meet telephonically. In administering the Plan, the Committee’s actions and determinations
shall be binding on all interested parties. The Committee shall have the power to grant Options or Awards in accordance with the provisions of the Plan and may grant Options and Awards singly, in combination, or in tandem; provided, however, that
the Committee shall not grant Incentive Stock Options in tandem with Options which do not qualify as Incentive Stock Options in such a manner that the exercise of one affects the right to exercise the other. Subject to the provisions of the Plan,
the Committee shall have the discretion and authority to determine those individuals to whom Options or Awards will be granted, the number of shares of Stock subject to each Option or Award, such other matters as are specified herein, and any other
terms and conditions of a Stock Option Agreement or Restriction Agreement. To the extent not inconsistent with the provisions of the Plan, the Committee may give a Grantee an election to surrender an Option or Award in exchange for the grant of a
new Option or Award, and shall have the authority to amend or modify an outstanding Stock Option Agreement or Restriction Agreement, or to waive any provision thereof, provided that the Grantee consents to such action. In the event the Company is
listed on the TSX Venture Exchange, the Committee shall cause the Company to comply with all filing requirements and obtain all regulatory approvals as set forth in the Manual. 
 4.2 Interpretation; Rules. Subject to the express provisions of the Plan, the Committee also shall have complete authority to interpret the Plan,
to prescribe, amend, and rescind rules and regulations relating to it, to determine the details and provisions of each Stock Option Agreement, and to make all other determinations necessary or advisable for the administration of the Plan, including,
without limitation, the amending or altering of the Plan and any Options or Awards granted under the Plan as may be required to comply with or to conform to any federal, state, or local laws or regulations. 
  

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 4.3 No Liability. Neither any member of the Board nor any member of the Committee shall be liable
to any person for any act or determination made in good faith with respect to the Plan or any Option or Award granted hereunder. 
 4.4
Majority Rule. A majority of the members of the Committee shall constitute a quorum, and any action taken by a majority at a meeting at which a quorum is present, or any action taken without a meeting evidenced by a writing executed by all
the members of the Committee, shall constitute the action of the Committee. 
 4.5 Company Assistance. The Company shall supply full
and timely information to the Committee on all matters relating to eligible persons, their employment, death, retirement, disability, or other termination of employment or service, and such other pertinent facts as the Committee may require. The
Company shall furnish the Committee with such clerical and other assistance as is necessary in the performance of its duties. 
 ARTICLE 5

 SHARES OF STOCK SUBJECT TO PLAN 
 5.1 Limitations. Subject to any antidilution adjustment pursuant to the provisions of Section 5.2 of this Plan, the maximum number of shares of Stock that may be issued hereunder shall be 1,000,000 shares
of Stock. Any or all shares of Stock subject to the Plan may be issued in any combination of Incentive Stock Options, non-Incentive Stock Options, Restricted Stock, or SARs, and the amount of Stock subject to the Plan may be increased from time to
time in accordance with Article 10, provided that the total number of shares of Stock issuable pursuant to Incentive Stock Options may not be increased to more than 1,000,000 (other than pursuant to anti-dilution adjustments) without shareholder
approval. Shares subject to an Option or issued as an Award may be either authorized and unissued shares or shares issued and later acquired by the Company. The shares covered by any unexercised portion of an Option that has terminated for any
reason (except as set forth in the following paragraph), or any forfeited portion of an Award, may again be optioned or awarded under the Plan, and such shares shall not be considered as having been optioned or issued in computing the number of
shares of Stock remaining available for option or award hereunder. 
 If Options are issued in respect of options to acquire stock of any
entity acquired, by merger or otherwise, by the Company (or any Subsidiary of the Company), to the extent that such issuance shall not be inconsistent with the terms, limitations and conditions of Code section 422 or Rule 16b-3 under the Exchange
Act, the aggregate number of shares of Stock for which Options may be granted hereunder shall automatically be increased by the number of shares subject to the Options so issued; provided, however, that the aggregate number of shares of Stock for
which Options may be granted hereunder shall automatically be decreased by the number of shares covered by any unexercised portion of an Option so issued that has terminated for any reason, and the shares subject to any such unexercised portion may
not be optioned to any other person. 
  

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 5.2 Adjustments Upon Occurrence of Certain Events. 
 (a) In the event of a Corporate Transaction, the Committee, in its discretion, may, but need not notwithstanding other provisions of this Plan:

 (i) declare that (1) all Options outstanding at the time of such Corporate Transaction but not otherwise fully
exercisable, shall become exercisable immediately, notwithstanding the provisions of the respective Stock Option Agreements regarding exercisability, so that such Options shall become exercisable for all shares at the time subject to such Options;
(2) all such Options shall terminate on a stated date or within a stated number of days after the Committee gives written notice of the immediate right to exercise all such Options and of the decision to terminate all Options not exercised by
such date or within such period; and/or (3) all then-remaining restrictions pertaining to Awards under the Plan shall immediately lapse; and/or 
 (ii) issue or assume Awards or Options, or arrange that all Options or Awards granted under the Plan shall be assumed by the surviving corporation in the Corporate Transaction or substituted on an equitable basis with
options or restricted stock issued by such surviving corporation and provide notice thereof to all Grantees of such adjustment. 
 (b) If, in
a transaction that is not a Corporate Transaction, (x) the outstanding shares of Stock are changed into or exchanged for a different number or kind of shares or other securities of the Company by reason of a reorganization, recapitalization,
reclassification, exchange of shares, or stock split or stock dividend, (y) there is any material spin-off or spin-out, or other material distribution of assets, or (z) there is any assumption and conversion to the Plan by the Company of
an acquired company’s outstanding option grants, then: 
 (i) the aggregate number and kind of shares of Stock for which
Options or Awards may be granted hereunder shall be adjusted appropriately by the Committee; and 
 (ii) the rights of
Optionees (concerning the number of shares subject to Options and the Exercise Price) under outstanding Options and the rights of the holders of Awards (concerning the terms and conditions of the lapse of any then-remaining restrictions), shall be
adjusted appropriately by the Committee. 
 (c) Liquidation or Dissolution. In the event of a liquidation or dissolution of the
Company in a transaction not involving a Corporate Transaction, then notwithstanding other provisions hereof: the adoption of a plan of dissolution or liquidation of the Company shall cause all then-remaining restrictions pertaining to Awards under
the Plan to lapse, and shall cause every Option outstanding under the Plan to terminate to the extent not exercised prior to the adoption of the plan of dissolution or liquidation by the shareholders; and the Committee may declare all Options
granted under the Plan to be exercisable at a time prior to the liquidation or dissolution to 
  

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 be determined by the Committee, notwithstanding the provisions of the respective Stock Option Agreements regarding
exercisability. 
 (d) Committee Has Discretion. The adjustments and other actions described in paragraphs (a) through
(c) of this Section 5.2, if any, and the manner of their application, shall be determined solely by the Committee, and any such adjustment may provide for the elimination of fractional share interests; provided, however, that any
adjustment made by the Committee shall be made in a manner that will not cause an Incentive Stock Option to be other than an Incentive Stock Option under applicable statutory and regulatory provisions. The adjustments required under this Article 5
shall apply to any successors of the Company and adjustments under 5.2(b) shall be made regardless of the number or type of successive events requiring such adjustments. 
 ARTICLE 6 
 OPTIONS 
 6.1 Types of Options Granted. The Committee may, under this Plan, grant either Incentive Stock Options or Options which do not qualify as
Incentive Stock Options. Within the limitations provided in this Plan, both types of Options may be granted to the same person at the same time, or at different times, under different terms and conditions, as long as the terms and conditions of each
Option are consistent with the provisions of the Plan. Without limitation of the foregoing, Options may be granted subject to conditions based on the financial performance of the Company or any other factor the Committee deems relevant. 

6.2 Option Grant and Agreement. Each Option granted hereunder shall be evidenced by minutes of a meeting or the written consent of the
Committee and by a written Stock Option Agreement executed by the Company and the Optionee. The terms of the Option, including the Option’s duration, time or times of exercise, Exercise Price, and whether the Option is intended to be an
Incentive Stock Option, shall be stated in the Stock Option Agreement. No Incentive Stock Option may be granted more than ten years after the earlier to occur of the effective date of the Plan or the date the Plan is approved by the Company’s
shareholders. 
 Separate Stock Option Agreements may be used for Options intended to be Incentive Stock Options and those not so intended,
but any failure to use such separate agreements shall not invalidate, or otherwise adversely affect the Optionee’s interest in, the Options evidenced thereby. 
 6.3 Optionee Limitations. The Committee shall not grant an Incentive Stock Option to any person who, at the time the Incentive Stock Option is granted: 
 (a) is not an Employee; or 
 (b) owns or is
considered to own stock possessing at least 10% of the total combined voting power of all classes of stock of the Company or any of its Parent or Subsidiary corporations; provided, however, that this limitation shall not apply if at the time an
Incentive Stock Option is granted the Exercise Price is at least 110% of the Fair Market Value of the Stock 
  

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 subject to such Option and such Option by its terms would not be exercisable after five years from the date on which the
Option is granted. For the purpose of this subsection (b), a person shall be considered to own: (i) the stock owned, directly or indirectly, by or for his or her brothers and sisters (whether by whole or half blood), spouse, ancestors and
lineal descendants; (ii) the stock owned, directly or indirectly, by or for a corporation, partnership, estate, or trust in proportion to such person’s stock interest, partnership interest or beneficial interest therein; and (iii) the
stock which such person may purchase under any outstanding options of the Company or of any Parent or Subsidiary of the Company. 
 6.4
$100,000 and Section 162(m) Limitations. Except as provided below, the Committee shall not grant an Incentive Stock Option to, or modify the exercise provisions of outstanding Incentive Stock Options held by, any person who, at the time
the Incentive Stock Option is granted (or modified), would thereby receive or hold any Incentive Stock Options of the Company and any Parent or Subsidiary of the Company, such that the aggregate Fair Market Value (determined as of the respective
dates of grant or modification of each option) of the stock with respect to which such Incentive Stock Options are exercisable for the first time during any calendar year is in excess of $100,000 (or such other limit as may be prescribed by the Code
from time to time); provided that the foregoing restriction on modification of outstanding Incentive Stock Options shall not preclude the Committee from modifying an outstanding Incentive Stock Option if, as a result of such modification and
with the consent of the Optionee, such Option no longer constitutes an Incentive Stock Option; and provided that, if the $100,000 limitation (or such other limitation prescribed by the Code) described in this Section 6.4 is exceeded, the
Incentive Stock Option, the granting or modification of which resulted in the exceeding of such limit, shall be treated as an Incentive Stock Option up to the limitation and the excess shall be treated as an Option not qualifying as an Incentive
Stock Option. 
 6.5 Exercise Price. The Exercise Price of the Stock subject to each Option shall be determined by the Committee;
provided, however, the Exercise Price of an Incentive Stock Option shall not be less than the Fair Market Value of the Stock as of the date the Option is granted (or in the case of an Incentive Stock Option that is subsequently
modified, on the date of such modification). 
 6.6 Exercise Period. The period for the exercise of each Option granted hereunder
shall be determined by the Committee, but the Stock Option Agreement with respect to each Option shall provide that such Option shall not be exercisable after the expiration of ten years from the date of grant of the Option. The Committee shall
determine the vesting period over which each share granted is to vest. 
 6.7 Option Exercise. 
 (a) Unless otherwise provided in the Stock Option Agreement or Section 6.6 of this Plan, an Option may be exercised at any time or from time to time
during the term of the Option as to any or all full shares which have become Purchasable under the provisions of the Option, but not at any time as to fewer than 100 shares unless the remaining shares that have become so Purchasable are fewer than
100 shares. The Committee shall have the authority to prescribe in any Stock Option Agreement that the Option may be exercised only in accordance with a vesting schedule during the term of the Option. 
  

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 (b) An Option shall be exercised by (i) delivery to the Company at its principal office of a written
notice of exercise with respect to a specified number of shares of Stock and (ii) payment to the Company at that office of the full amount of the Exercise Price for such number of shares in accordance with Section 6.7(c). If requested by
an Optionee, an Option (other than an Incentive Stock Option) may be exercised with the involvement of a stockbroker in accordance with the federal margin rules set forth in Regulation T (in which case the certificates representing the underlying
shares will be delivered by the Company directly to the stockbroker). 
 (c) The Exercise Price is to be paid in full in cash upon the
exercise of the Option, and the Company shall not be required to deliver certificates for the shares purchased until such payment has been made; provided, however, that in lieu of cash, in the Company’s sole discretion, all or any portion of
the Exercise Price may be paid by tendering to the Company shares of Stock duly endorsed for transfer and owned by the Optionee, or by authorization to the Company to withhold shares of Stock otherwise issuable upon exercise of the Option, in each
case to be credited against the Exercise Price at the Fair Market Value of such shares on the date of exercise (however, no fractional shares may be so transferred, and the Company shall not be obligated to make any cash payments in consideration of
any excess of the aggregate Fair Market Value of shares transferred over the aggregate Exercise Price); provided further, that the Board may provide in a Stock Option Agreement (or may otherwise determine in its sole discretion at the time of
exercise) that, in lieu of cash or shares, all or a portion of the Exercise Price may be paid by the Optionee’s execution of a recourse note equal to the Exercise Price or relevant portion thereof, subject to compliance with applicable state
and federal laws, rules and regulations. 
 (d) In addition to and at the time of payment of the Exercise Price, the Optionee shall pay to
the Company in cash the full amount of any federal, state, and local income, employment, or other withholding taxes applicable to the taxable income of such Optionee resulting from such exercise; provided, however, that in the discretion of the
Committee any Stock Option Agreement may provide that all or any portion of such tax obligations, together with additional taxes not exceeding the actual additional taxes to be owed by the Optionee as a result of such exercise, may, upon the
irrevocable election of the Optionee, be paid by tendering to the Company whole shares of Stock duly endorsed for transfer and owned by the Optionee, or by authorization to the Company to withhold shares of Stock otherwise issuable upon exercise of
the Option, in either case in that number of shares having a Fair Market Value on the date of exercise equal to the amount of such taxes thereby being paid, and subject to such restrictions as to the approval and timing of any such election as the
Committee may from time to time determine to be necessary or appropriate to satisfy the conditions of the exemption set forth in Rule 16b-3 under the Exchange Act, if such rule is applicable. 
 (e) The holder of an Option shall not have any of the rights of a shareholder with respect to the shares of Stock subject to the Option until such shares
have been issued and transferred to the Optionee upon the exercise of the Option. 
  

 49 

 6.8 Nontransferability of Option. No Option shall be transferable by an Optionee other than by
will or the laws of descent and distribution or, in the case of non-Incentive Stock Options, pursuant to a Qualified Domestic Relations Order, and, during the lifetime of an Optionee, Options shall be exercisable only by such Optionee (or by such
Optionee’s guardian or legal representative, should one be appointed). 
 6.9 Termination of Employment or Service. The Committee
shall have the power to specify, with respect to the Options granted to a particular Optionee, the effect upon such Optionee’s right to exercise an Option of termination of such Optionee’s employment or service under various circumstances,
which effect may include immediate or deferred termination of such Optionee’s rights under an Option, or acceleration of the date at which an Option may be exercised in full; provided, that in no event may an Option be exercised after
the expiration of ten years from the date of its grant. Further, in no event may an Option be exercised more than ninety (90) days following termination of such Optionee’s employment and/or service, unless termination is due to
Optionee’s death, in which case an Option may be exercised within one year following such termination. 
 6.10 Employment Rights.
Nothing in the Plan or in any Stock Option Agreement shall confer on any person any right to continue in the employ of the Company or any of its Subsidiaries, or shall interfere in any way with the right of the Company or any of its Subsidiaries to
terminate such person’s employment at any time. 
 6.11 Certain Successor Options. To the extent not inconsistent with the terms,
limitations and conditions of Code section 422 and any regulations promulgated with respect thereto, an Option issued in respect of an option held by an employee to acquire stock of any entity acquired, by merger or otherwise, by the Company (or any
Subsidiary of the Company) may contain terms that differ from those stated in this Article 6, but solely to the extent necessary to preserve for any such employee the rights and benefits contained in such predecessor option, or to satisfy the
requirements of Code section 424(a). 
 6.12 Other Restrictions. In addition to the general requirements herein, the following
restrictions apply to all Options granted under the Plan: 
 (a) The aggregate number of shares of Stock reserved for issuance under Options
granted hereunder to Insiders (as defined in the Manual) shall not exceed ten percent (10%) of the outstanding Stock; 
 (b) The
aggregate number of shares of Stock for which Options may be granted to Insiders, within a one (1) year period, shall not exceed ten percent (10%) of the outstanding Stock; 
 (c) The aggregate number of shares of Stock for which Options may be granted to any one Insider and such Insider’s Associates (as defined in the
Manual), within a one (1) year period, shall not exceed five percent (5%) of the outstanding Stock; 
  

 50 

 (d) The aggregate number of shares of Stock for which Options may be granted to a single individual,
within a one (1) year period, shall not exceed five percent (5%) of the outstanding Stock; 
 (e) Options granted to an Optionee
who is engaged in Investor Relations Activities (as defined in the Manual) shall expire thirty (30) days after the Optionee ceases to be employed to provide Investor Relations Activities; 
 (f) The aggregate number of shares of Stock subject to an Option granted to a consultant or to persons employed in Investor Relations Activities shall
not exceed two percent (2%) of the outstanding Stock at the time of grant; 
 (g) Options granted to consultants assisting in Investor
Relations Activities shall vest in stages over a period of no less than 12 months with no more than one-quarter (1/4) of the Options vesting in any three month period; and 
 (h) The Exercise Price for an Option granted to any Insider shall not be reduced without obtaining disinterested shareholder approval. 
 ARTICLE 7 
 RESTRICTED STOCK

 7.1 Awards of Restricted Stock. The Committee may grant Awards of Restricted Stock, which shall be governed by a Restriction
Agreement between the Company and the Grantee. Each Restriction Agreement shall contain such restrictions, terms, and conditions as the Committee may, in its discretion, determine, and may require that an appropriate legend be placed on the
certificates evidencing the subject Restricted Stock. Shares of Restricted Stock granted pursuant to an Award hereunder shall be issued in the name of the Grantee as soon as reasonably practicable after the Award is granted, provided that the
Grantee has executed the Restriction Agreement governing the Award, the appropriate blank stock powers and, in the discretion of the Committee, an escrow agreement and any other documents which the Committee may require as a condition to the
issuance of such Shares. If a Grantee shall fail to execute the foregoing documents within any time period prescribed by the Committee, the Award shall be void. At the discretion of the Committee, Shares issued in connection with an Award shall be
deposited together with the stock powers with an escrow agent designated by the Committee. Unless the Committee determines otherwise and as set forth in the Restriction Agreement, upon delivery of the Shares to the escrow agent, the Grantee shall
have all of the rights of a shareholder with respect to such Shares, including the right to vote the Shares and to receive all dividends or other distributions paid or made with respect to the Shares. 
 7.2 Non-Transferability. Until any restrictions upon Restricted Stock awarded to a Grantee shall have lapsed in a manner set forth in
Section 7.3, such shares of Restricted Stock shall not be transferable other than by will or the laws of descent and distribution, or pursuant to a Qualified Domestic Relations Order, nor shall they be delivered to the Grantee. 
  

 51 

 7.3 Lapse of Restrictions. Restrictions upon Restricted Stock awarded hereunder shall lapse at
such time or times (but, with respect to any award to a Grantee who is also a Section 16 Insider, not less than six months after the date of the Award) and on such terms and conditions as the Committee may, in its discretion, determine at the
time the Award is granted or thereafter. 
 7.4 Termination of Employment or Service. The Committee shall have the power to specify,
with respect to each Award granted to any particular Grantee, the effect upon such Grantee’s rights with respect to such Restricted Stock of the termination of such Grantee’s employment or service under various circumstances, which effect
may include immediate or deferred forfeiture of such Restricted Stock or acceleration of the date at which any then-remaining restrictions shall lapse; provided, however, that any unvested Restricted Stock shall immediately vest and any
then-remaining restrictions shall lapse upon the death of the Grantee. 
 7.5 Treatment of Dividends. At the time an Award of
Restricted Stock is made, the Committee may, in its discretion, determine that the payment to the Grantee of any dividends, or a specified portion thereof, declared or paid on such Restricted Stock shall be (i) deferred until the lapsing of the
relevant restrictions and (ii) held by the Company for the account of the Grantee until such lapsing. In the event of such deferral, there shall be credited at the end of each year (or portion thereof) interest on the amount of the account at
the beginning of the year at a rate per annum determined by the Committee. Payment of deferred dividends, together with interest thereon, shall be made upon the lapsing of restrictions imposed on such Restricted Stock, and any dividends deferred
(together with any interest thereon) in respect of Restricted Stock shall be forfeited upon any forfeiture of such Restricted Stock. 
 7.6
Delivery of Shares. Except as provided otherwise in Article 9 below, within a reasonable period of time following the lapse of the restrictions on shares of Restricted Stock, the Committee shall cause a stock certificate to be delivered to
the Grantee with respect to such shares and such shares shall be free of all restrictions hereunder. 
 ARTICLE 8 
 STOCK APPRECIATION RIGHTS 
 8.1 SAR
Grants. The Committee, in its sole discretion, may grant to any Grantee a SAR. The Committee may impose such conditions or restrictions on the exercise of any SAR as it may deem appropriate, including, without limitation, restricting the time of
exercise of the SAR to specified periods as may be necessary to satisfy the requirements of Rule 16b-3. 
 8.2 Determination of Price.
The SAR Price shall be established by the Committee in its sole discretion. The SAR Price shall not be less than 100% (110% for a Grantee described in Section 6.3(b) hereof) of Fair Market Value of the Stock on the date the SAR is granted for a
SAR issued in tandem with an Incentive Stock Option. 
  

 52 

 8.3 Exercise of a SAR. Upon exercise of a SAR, the Grantee shall be entitled, subject to the terms
and conditions of this Plan and the Agreement, to receive the excess for each share of Stock being exercised under the SAR of (i) the Fair Market Value of such share of Stock on the date of exercise over (ii) the SAR Price for such share
of Stock. 
 8.4 Payment for a SAR. At the sole discretion of the Committee, the payment of such excess shall be made in
(i) cash, (ii) shares of Stock, or (iii) a combination of both. Shares of Stock used for this payment shall be valued at their Fair Market Value on the date of exercise of the applicable SAR. 
 8.5 Status of a SAR under the Plan. Shares of Stock subject to an Award of a SAR shall be considered shares of Stock which may be issued under the
Plan for purposes of Section 5.1 of this Plan, unless the Agreement making the Award of the SAR provides that the exercise of such SAR results in the termination of an unexercised Option for the same number of shares of Stock. 
 8.6 Termination of SARs. A SAR may be terminated as follows: 
  

	 	(a)	During the period of continuous employment or service with the Company, Parent or Subsidiary, a SAR will be terminated only if it has been fully exercised or it has expired by its
terms. 

  

	 	(b)	Upon termination of employment or service, the SAR will terminate upon the earliest of (i) the full exercise of the SAR, (ii) the expiration of the SAR by its terms, and
(iii) not more than three months following the date of employment termination; provided, however, should termination of employment (A) result from the death of the Grantee, the period referenced in clause (iii) hereof shall be one
year or (B) be for Cause, the SAR will terminate on the date of termination. For purpose of the Plan, a leave of absence approved by the Company shall not be deemed to be termination of employment unless otherwise provided in the Agreement or
by the Company on the date of the leave of absence. 

  

	 	(c)	Subject to the terms of the Agreement with the Grantee, if a Grantee shall die prior to the termination of employment or service with the Company, Parent or Subsidiary and prior to
the termination of a SAR, such SAR may be exercised to the extent that the Grantee shall have been entitled to exercise it at the time of death or disability, as the case may be, by the Grantee, the estate of the Grantee or the person or persons to
whom the SAR may have been transferred by will or by the laws of descent and distribution. 

  

	 	(d)	Except as otherwise expressly provided in the Agreement with the Grantee, in no event will the continuation of the term of a SAR beyond the date of termination of employment allow
the Employee, or the Employee’s beneficiaries or heirs, to accrue additional rights under the Plan, have additional SARs available for exercise, or receive a higher benefit than the benefit payable as if the SAR had been exercised on the date
of employment termination. 

  

 53 

 8.7 No Shareholder Rights. The Grantee shall have no rights as a shareholder with respect to a
SAR. In addition, no adjustment shall be made for dividends (ordinary or extraordinary, whether in cash, securities or other property) or distributions or rights except as provided in Section 5.2 of this Plan. 
 8.8. SARs Granted in Tandem with Incentive Stock Options. In addition to the foregoing provisions, a SAR granted in tandem with an Incentive Stock
Option shall be subject to the following requirements: 
 (a) The SAR must expire no later than the expiration of the underlying Incentive
Stock Option; 
 (b) The SAR may be transferred only when the underlying Incentive Stock Option may be transferred and subject to the same
conditions. 
 (c) The SAR may be exercised only when the underlying Incentive Stock Option may be exercised; and 
 (d) The SAR may be exercised only when the Fair Market Value of the Stock exceeds the Exercise Price of the underlying Incentive Stock Option. 

ARTICLE 9 
 STOCK CERTIFICATES

 The Company shall not be required to issue or deliver any certificate for shares of Stock purchased upon the attempted exercise of any
Option granted hereunder or any portion thereof, or deliver any certificate for shares of Restricted Stock granted hereunder, and no attempted exercise of an Option shall be effective prior to fulfillment of all of the following conditions:

 (a) The admission of such shares to listing on all stock exchanges on which the Stock is then listed; 
 (b) The completion of any registration or other qualification of such shares which the Committee shall deem necessary or advisable under any federal or
state law or under the rulings or regulations of the SEC or any other governmental regulatory body; 
 (c) The obtaining of any approval or
other clearance from any federal or state governmental agency or body which the Committee shall determine to be necessary or advisable; and 
  

 54 

 (d) The lapse of such reasonable period of time following the exercise of the Option as the Board from
time to time may establish for reasons of administrative convenience. 
 Stock certificates issued and delivered to Grantees shall bear such
restrictive legends as the Company shall deem necessary or advisable pursuant to applicable federal and state securities laws. The inability of the Company to obtain approval from any regulatory body having authority deemed by the Company to be
necessary to the lawful issuance and sale of any Stock pursuant to Options shall relieve the Company of any liability with respect to the non-issuance or sale of the Stock as to which such approval shall not have been obtained. The Company shall,
however, use reasonable efforts to obtain all such approvals. 
 ARTICLE 10 
 TERMINATION AND AMENDMENT 
 10.1 Termination and Amendment. The Board may
at any time terminate or amend the Plan; provided, however, that the Board (unless its actions are approved or ratified by the shareholders of the Company within twelve months of the date that the Board amends the Plan) may not amend the Plan to:

 (a) Increase the total number of shares of Stock issuable pursuant to Incentive Stock Options under the Plan, except as contemplated in
Section 5.2; or 
 (b) Change the class of employees eligible to receive Incentive Stock Options that may participate in the Plan.

 10.2 Effect on Grantee’s Rights. No termination, amendment, or modification of the Plan shall affect adversely a
Grantee’s rights under a Stock Option Agreement or Restriction Agreement without the consent of the Grantee or his legal representative. 
 ARTICLE 11 
 RELATIONSHIP TO OTHER COMPENSATION PLANS 
 The adoption of the Plan shall not affect any other stock option, incentive, or other compensation plans in effect for the Company or any of its
Subsidiaries; nor shall the adoption of the Plan preclude the Company or any of its Subsidiaries from establishing any other form of incentive or other compensation plan for Employees or Directors of the Company or any of its Subsidiaries.

 ARTICLE 12 
 MISCELLANEOUS 
 12.1 Replacement or Amended Grants. At the sole discretion of the Committee, and subject to the terms
of the Plan, the Committee may modify outstanding Options or Awards or 
  

 55 

 accept the surrender of outstanding Options or Awards and grant new Options or Awards in substitution for them, provided
that no modification of an Option or Award shall adversely affect a Grantee’s rights under a Stock Option Agreement or Restriction Agreement without the consent of the Grantee or his legal representative. 
 12.2 Leave of Absence. Unless provided otherwise in a particular Stock Option Agreement, the following provisions shall apply upon an
Optionee’s commencement of an authorized leave of absence: 
 (a) The exercise schedule in effect for such Option shall be frozen as of
the first day of the authorized leave, and the Option shall not become exercisable for any additional installments of shares of Stock during the period Optionee remains on such leave. 
 (b) Should Optionee resume active Employee status within 60 days after the start date of the authorized leave, Optionee shall, for purposes of the
applicable exercise schedule, receive service credit for the entire period of such leave. If Optionee does not resume active Employee status within such 60-day period, then no credit shall be given for the entire period of such leave. 
 (c) In no event shall the Option become exercisable for any additional shares or otherwise remain outstanding if the Optionee does not resume Employee
status prior to the Expiration Date of the option term. 
 12.3 Plan Binding on Successors. The Plan shall be binding upon the
successors and assigns of the Company. 
 12.4 Singular, Plural; Gender. Whenever used in this Plan, nouns in the singular shall
include the plural, and the masculine pronoun shall include the feminine gender. 
 12.5 Headings, etc., No Part of Plan. Headings of
Articles and Sections of this Plan are inserted for convenience and reference; they do not constitute part of the Plan. 
 12.6
Section 16 Compliance. With respect to Section 16 Insiders and “highly-compensated” persons under Section 162(m) of the Code, transactions under this Plan are intended to comply with all applicable conditions of Rule
16b-3 or its successors under the Exchange Act and with Section 162(m) of the Code. To the extent any provision of the Plan or action by the Committee fails to so comply, it shall be deemed void to the extent permitted by law and deemed
advisable by the Committee. In addition, if necessary to comply with Rule 16b-3 with respect to any grant of an Option hereunder, and in addition to any other vesting or holding period specified hereunder or in an applicable Stock Option Agreement,
any Section 16 Insider acquiring an Option shall be required to hold either the Option or the underlying shares of Stock obtained upon exercise of the Option for a minimum of six months. 
  

 56 

 EXHIBIT A to 
 Oragenics, Inc. 
 2002 Stock Option and Incentive Plan - 
 Form of Stock Option Agreement 
 [Employees] 
 ORAGENICS, INC. 
 STOCK OPTION
AGREEMENT 
 THE TRANSFER OF THESE SECURITIES HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR ANY OTHER APPLICABLE BLUE SKY
LAWS, AND CANNOT BE SOLD OR OTHERWISE TRANSFERRED UNLESS SUCH SALE OR TRANSFER IS REGISTERED UNDER SUCH ACTS, OR EXEMPTIONS FROM SUCH REGISTRATION ARE AVAILABLE. 
 THIS STOCK OPTION AGREEMENT (this “Agreement”) is entered into as of this      day of
                     ,              , by and between
Oragenics, Inc., a Florida corporation (the “Company”), and                      (the “Optionee”). 
 WHEREAS, on                 , 2002, the Board of Directors of the
Company adopted a Stock Option and Incentive Plan known as the Company’s “2002 Stock Option and Incentive Plan” (the “Plan”), and recommended that the Plan be approved by the Company’s shareholders; and 
 WHEREAS, on                 , 2002, the shareholders of the
Company adopted and approved the Plan; and 
 WHEREAS, the Committee has granted the Optionee a stock option to purchase the number of shares
of the Company’s common stock as set forth below, and in consideration of the granting of that stock option the Optionee intends to remain in the employ of the Company; and 
 WHEREAS, the Company and the Optionee desire to enter into a written agreement with respect to such option in accordance with the Plan. 
 NOW, THEREFORE, as an employment incentive and to encourage stock ownership, and also in consideration of the mutual covenants contained herein, the
parties hereto agree as follows. 
 1. Incorporation of Plan. This option is granted pursuant to the provisions of the Plan, and the
terms and definitions of the Plan are incorporated into this Agreement by reference and made a part of this Agreement. The Optionee acknowledges receipt of a copy of the Plan. 
  

 A-1 

 2. Grant of Option. Subject to the terms, restrictions, limitations and conditions stated in this
Agreement, the Company hereby evidences its grant to the Optionee, not in lieu of salary or other compensation, of the right and option (the “Option”) to purchase all or any part of the number of shares of the Company’s Common Stock,
$.001 par value per share (the “Stock”), set forth on Schedule A attached and incorporated into this Agreement by reference. The Option shall be exercisable in the amounts and at the time(s) specified on Schedule A. The Option shall expire
and shall not be exercisable on the date specified on Schedule A or on such earlier date as determined pursuant to Section 8 or 9 of this Agreement. Schedule A states whether the Option is intended to be an Incentive Stock Option. 

3. Purchase Price. The price per share to be paid by the Optionee for the shares subject to this Option (the “Exercise Price”) shall
be as specified on Schedule A, which price shall be an amount not less than the Fair Market Value (or 110% of the Fair Market Value if Optionee is a person described in Section 6.3(b) of the Plan) of a share of Stock as of the Date of Grant (as
defined in Section 10 below) if the Option is an Incentive Stock Option. 
 4. Exercise Terms. The Optionee must exercise the
Option for at least the lesser of 100 shares or the number of shares of Purchasable Stock as to which the Option remains unexercised. If this Option is not exercised with respect to all or any part of the shares subject to this Option prior to its
expiration, the shares with respect to which this Option was not exercised shall no longer be subject to this Option. 
 5. Option
Non-Transferable. No Option shall be transferable by an Optionee other than by will or the laws of descent and distribution or, in the case of non-Incentive Stock Options, pursuant to a Qualified Domestic Relations Order or as otherwise
permitted pursuant to Section 6.8 of the Plan. During the lifetime of an Optionee, Options shall be exercisable only by such Optionee (or by such Optionee’s guardian or legal representative, should one be appointed). 
 6. Notice of Exercise of Option. This Option may be exercised by the Optionee, or by the Optionee’s administrators, executors or personal
representatives, by a written notice (in substantially the form of the Notice of Exercise attached to this Agreement as Schedule B) signed by the Optionee, or by such administrators, executors or personal representatives, and delivered or mailed to
the Company as specified in Section 14 below to the attention of the President, Chief Executive Officer or such other officer as the President or Chief Executive Officer may designate. Any such notice shall (a) specify the number of shares
of Stock which the Optionee or the Optionee’s administrators, executors or personal representatives, as the case may be, then elects to purchase hereunder, (b) contain such information as may be reasonably required pursuant to
Section 11 below, and (c) be accompanied by (i) a certified or cashier’s check or, if acceptable to the Committee, a recourse note payable to the Company in payment of the total Exercise Price applicable to such shares as
provided herein, (ii) shares of Stock owned by the Optionee and duly endorsed or accompanied by stock transfer powers having a Fair Market Value equal to the total Exercise Price applicable to such shares purchased under this Agreement, or
(iii) a certified or cashier’s check or, if acceptable to the 
  

 A-2 

 Committee, a recourse note payable to the Company, accompanied by the number of shares of Stock whose Fair Market Value
when added to the amount of the check or note equals the total Exercise Price applicable to the shares being purchased under this Agreement. Upon receipt of any such notice and accompanying payment, and subject to the terms hereof, the Company
agrees to issue to the Optionee or the Optionee’s administrators, executors or personal representatives, as the case may be, stock certificates for the number of shares specified in such notice registered in the name of the person exercising
this Option. 
 7. Adjustment in Option. The number of Shares subject to this Option, the Exercise Price and other matters are subject
to adjustment during the term of this Option in accordance with Section 5.2 of the Plan. 
 8. Termination of Employment.

 (a) Except as otherwise specified in Schedule A to this Agreement, in the event of the termination of the Optionee’s employment with
the Company or any of its Subsidiaries, other than a termination that is either (i) for Cause, (ii) voluntary on the part of the Optionee and without written consent of the Company, or (iii) for reasons of death or retirement, the
Optionee may exercise this Option at any time within ninety (90) days after such termination to the extent of the number of shares which were Purchasable hereunder at the date of such termination. 
 (b) Except as specified in Schedule A attached hereto, in the event of a termination of the Optionee’s employment that is either (i) for Cause
or (ii) voluntary on the part of the Optionee and without the written consent of the Company, this Option, to the extent not previously exercised, shall terminate immediately and shall not thereafter be or become exercisable. 
 (c) Unless and to the extent otherwise provided in Schedule A hereto, in the event of the retirement of the Optionee at the normal retirement date as
prescribed from time to time by the Company or any Subsidiary, the Optionee shall continue to have the right to exercise any Options for shares which were Purchasable at the date of the Optionee’s retirement at any time within ninety
(90) days after the date of retirement. This Option does not confer upon the Optionee any right with respect to continuance of employment by the Company or by any of its Subsidiaries. This Option shall not be affected by any change of
employment so long as the Optionee continues to be an employee of the Company or one of its Subsidiaries. 
 9. Death of Optionee.
Except as otherwise set forth in Schedule A with respect to the rights of the Optionee upon termination of employment under Section 8(a) above, in the event of the Optionee’s death while employed by the Company or any of its Subsidiaries
or within three months after a termination of such employment (if such termination was neither (i) for cause nor (ii) voluntary on the part of the Optionee and without the written consent of the Company), the appropriate persons described
in Section 6 of this Agreement or persons to whom all or a portion of this Option is transferred in accordance with Section 5 of this Agreement may exercise this Option at any time within a period ending on the earlier of (a)
  

 A-3 

 the last day of the one year period following the Optionee’s death or (b) the expiration date of this Option.
If the Optionee was an employee of the Company at the time of death, any unvested rights to acquire shares pursuant to this Option shall immediately vest and this Option may be so exercised to the extent of the number of shares that were Purchasable
under this Agreement at the date of death. If the Optionee’s employment terminated prior to his or her death, this Option may be exercised only to the extent of the number of shares covered by this Option which were Purchasable under this
Agreement at the date of such termination. 
 10. Date of Grant. This Option was granted by the Committee on the date set forth in
Schedule A (the “Date of Grant”). 
 11. Compliance with Regulatory Matters. The Optionee acknowledges that the issuance of
capital stock of the Company is subject to limitations imposed by federal and state law, and the Optionee hereby agrees that the Company shall not be obligated to issue any shares of Stock upon an attempted exercise of this Option that would cause
the Company to violate law or any rule, regulation, order or consent decree of any regulatory authority (including without limitation the SEC) having jurisdiction over the affairs of the Company. The Optionee agrees that he or she will provide the
Company with such information as is reasonably requested by the Company or its counsel to determine whether the issuance of Stock complies with the provisions described by this Section 11. 
 12. Restriction on Disposition of Shares. Unless the Company otherwise agrees in writing, the shares purchased pursuant to the exercise of an
Incentive Stock Option shall not be transferred by the Optionee except pursuant to the Optionee’s will, or the laws of descent and distribution, until such date which is the later of two years after the grant of such Incentive Stock Option or
one year after the transfer of the shares to the Optionee pursuant to the exercise of such Incentive Stock Option. 
 13. Termination as a
Subsidiary of the Company. In the event that Optionee is employed by a Subsidiary of the Company and the Company or its Subsidiaries cease to own greater than 50% of such Subsidiary, this Option shall terminate on the date the Company or its
Subsidiaries cease to own greater than 50% of such Subsidiary unless the Board or the Committee determines otherwise. 
 14.
Miscellaneous. 
 (a) This Agreement shall be binding upon the parties hereto and their representatives, successors and assigns.

 (b) This Agreement is executed and delivered in, and shall be governed by the laws of, the State of Georgia. 
 (c) Any requests or notices to be given hereunder shall be deemed given, and any elections or exercises to be made or accomplished shall be deemed made or
accomplished, upon actual delivery thereof to the designated recipient, or three days after deposit thereof in 
  

 A-4 

 the United States mail, registered, return receipt requested and postage prepaid, addressed, if to the Optionee, at the
address set forth below and, if to the Company, to the executive offices of the Company at 12085 Research Drive, Alachua, Florida 32615, or at such other addresses that the parties provide to each other in accordance with the foregoing notice
requirements. 
 (d) This Agreement may not be modified except in writing executed by each of the parties to it. 
 IN WITNESS WHEREOF, the Committee has caused this Stock Option Agreement to be executed on behalf of the Company, and the Optionee has executed this
Stock Option Agreement, all as of the day and year first above written. 
  

							
	ORAGENICS, INC.	  	OPTIONEE
			
	By:	 	  
	  	  

	Name:	 	  
	  	Name:	 	  

	Title:	 	  
	  	Address:	 	  

		 		  		 	  

		 		  		 	  

  

 A-5 

 SCHEDULE A 
 TO 
 STOCK OPTION AGREEMENT 
 BETWEEN 
 ORAGENICS, INC. 
 AND 
 __________________________________ 
 Dated:
                         
 1.
Number of Shares Subject to Option:                      Shares. 
 2. This Option (Check one) [ ] is [ ] is not an Incentive Stock Option. 
 3. Option Exercise
Price: $                  per Share. 
 4. Date of Grant:
                             
 5. Option Vesting Schedule: 
     Check one: 
  

	 	(    )	Options are exercisable with respect to all shares on or after the date hereof. 

	 	(    )	Options are exercisable with respect to the number of shares indicated below on or after the date indicated next to the number of shares: 

  

			
	 No. of Shares
	  	 Vesting Date

 6. Option Exercise Period: 
     Check One: 
  

	 	(    )	All options expire and are void unless exercised on or before
                    ,         . 

	 	(    )	Options expire and are void unless exercised on or before the date indicated next to the number of shares: 

  

			
	 No. of Shares
	  	 Expiration Date

  
 7. Effect of Termination of Employment of
Optionee. [If different from Sections 8 or 9 of Stock Option Agreement] 

 SCHEDULE B 
 TO 
 STOCK OPTION AGREEMENT 
 BETWEEN 
 ORAGENICS, INC. 
 AND 
  
 __________________________________ 
 Dated:
                     
 NOTICE
OF EXERCISE 
 The undersigned hereby notifies Oragenics, Inc. (the “Company”) of this election to exercise the
undersigned’s stock option to purchase                      shares of the Company’s common stock, $.001 par value per share (the
“Common Stock”), pursuant to the Stock Option Agreement (the “Agreement”) between the undersigned and the Company dated
                    ,         . Accompanying this Notice is (1) a certified or a
cashier’s check or, if acceptable to the Committee, a recourse note payable to the Company, in the amount of $                    
payable to the Company, and/or (2)                 shares of the Company’s Common Stock presently owned by the undersigned and duly endorsed or
accompanied by stock transfer powers, having an aggregate Fair Market Value (as defined in the Company’s 2002 Stock Option and Incentive Plan (the “Plan”)) as of the date hereof of
$                    , and/or (3) authorization to withhold
                 shares of Stock otherwise issuable upon exercise of the Option having an aggregate Fair Market Value (as defined in the Plan) as of the date
hereof of $                    , with such shares of Stock that are withheld being credited against the Exercise Price, such amounts of (1),
(2) and (3) being equal, in the aggregate, to the purchase price per share set forth in Section 3 of the Agreement multiplied by the number of shares being purchased hereby (in each instance subject to appropriate adjustment pursuant
to Section 5.2 of the Plan). 
 IN WITNESS WHEREOF, the undersigned has set his hand and seal, this
             day of                      ,
        . 
  
  

			
	 OPTIONEE [OR OPTIONEE’S ADMINISTRATOR,
 EXECUTOR OR PERSONAL REPRESENTATIVE]

	  

	Name:                                     
                                      
 
	Position (if other than Optionee):Second Lease Amendment

 Exhibit 10.2 
  

					
	NORTH CAROLINA	  	)	  	
		  	)	  	 SECOND LEASE AMENDMENT

	FORSYTH COUNTY	  	)	  	

 This Second Lease Amendment (“Amendment”), made effective as of the 31st day of March, 2006 (the “Amendment Date”), by and between Wake Forest University Health Sciences, a North Carolina
non-profit corporation having its principal office in Winston-Salem, North Carolina (“Landlord”); and Targacept, Inc., a Delaware corporation having its principal office in Winston-Salem, North Carolina (“Tenant”), amends that
Lease entered into between the parties effective August 1, 2002 as amended by First Lease Amendment effective January 1, 2005 (the “Lease”). 
 WITNESSETH: 
 WHEREAS, Landlord has granted Tenant in the Lease an option to lease up to 12,338 additional rentable square
feet of space on the first floor of the building (the “First Floor Option Space”), as provided in paragraph 2.3.1 of the Lease, provided that Tenant paid to Landlord on or before January 1, 2005 the sum of $37,014 as a “space
hold fee” to secure such right for the period from January 1, 2005 through March 31, 2006 (the “First Floor Option Period”); and 
 WHEREAS, Tenant paid to Landlord the $37,014 “space hold fee” on or before January 1, 2005; and 
 WHEREAS, Tenant desires to extend,
and Landlord is willing to grant an extension of, the First Floor Option Period for a period of one (1) year (through March 31, 2007), upon Tenant’s payment to Landlord, concurrent with its execution of this Amendment, of an
additional sum of $29,611.20 as an additional “space hold fee” to secure this right for the extended period; 
 NOW, THEREFORE, Landlord and Tenant
hereby agree as follows: 
 1. Unless otherwise defined herein, all of the capitalized terms of this Amendment shall have the same meanings ascribed to them
in the Lease. 
 2. The Lease is amended by deleting paragraph 2.3.1 and substituting in lieu thereof the following: 
  

			
	2.3.1	 	First Floor Option
		
		 	Landlord hereby grants to Tenant the option to lease up to 12,338 additional rentable square feet of space on the first floor of the building (the “First Floor Option Space”),
provided Tenant shall have paid to Landlord on or before January 1, 2005 (the “Amendment Date”) the sum of $37,014 ($3.00 per rsf) as a “space hold fee” to secure this right for the period from the Amendment Date through March
31, 2006 (the “First Floor Option Period”); provided further that Tenant may extend the First Floor Option Period, upon payment to Landlord of an additional $29,611.20 as a further “space hold fee” to secure this right for an
additional one (1) year period through March 31, 2007 (the “Extended First Floor

  

 1 

			
		 	Option Period”). Tenant will exercise this Option to Lease, if it elects to exercise, by giving written notice to Landlord not later than 60 days prior to Tenant’s intended occupancy
date for such First Floor Option Space (the “First Floor Occupancy Effective Date”). Exercise of this Option to Lease shall effect a lease of the First Floor Option Space from the First Floor Occupancy Effective Date through the balance of
the Initial Term and, only if Targacept elects both to exercise the Renewal Option and to continue to lease the First Floor Option Space during the Renewal Term, for the Renewal Term. If the Option to Lease the First Floor Option Space is exercised,
(a) the First Floor Option Space shall thereupon become part of the Demised Premises for the Initial Term and, subject to the conditions set forth in the preceding sentence, the Renewal Term and (b) Tenant will pay Rent for such First Floor Option
Space during the Initial Term and, subject to the conditions set forth in the preceding sentence, the Renewal Term as set forth in paragraphs 3.1 and 3.2; provided that (i) an amount equal to (A) $2,467.60 (representing the further space hold fee of
$29,611.20 divided by the 12 months in the Extended First Floor Option Period) times (B) the number of calendar months for which the first day occurs after the date on which Tenant exercises the Option to Lease the First Floor Option Space and
before March 31, 2007 shall be applied as a credit against the first Rent due for the First Floor Option Space and (ii) each space hold fee is nonrefundable in the event Tenant declines to exercise the Option to Lease the First Floor Option
Space.

  

	3.	Tenant shall pay to Landlord the sum of $29,611.20 coincident with the date of execution of this Amendment, thereby extending Tenant’s Option to Lease the First Floor Option
Space for the Extended First Floor Option Period as contemplated by paragraph 2.3.1 of the Lease, as amended herein. 

  

	4.	Except as amended herein, all of the terms and conditions of the Lease shall remain in full force and effect. 

 IN WITNESS WHEREOF, Landlord and Tenant have caused this Amendment to be executed, pursuant to authority duly granted, effective as of the Amendment Date
set forth above. 
  

									
	LANDLORD:	 		 	TENANT:
			
	Wake Forest University Health Sciences	 		 	Targacept, Inc.
					
	By:	 	 /s/ Richard H. Dean
	 		 	By:	 	 /s/ J. Donald deBethizy

		 	Richard H. Dean, M.D.	 		 		 	J. Donald deBethizy
		 	President	 		 		 	President
			
	Date: 6-23-06	 		 	Date: 06-30-06

  

 2

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