Document:

Exhibit 4.4

 THIS AGREEMENT is made on the 14th day of February
          2005 BETWEEN 

	(1)	ASTRAZENECA UK LIMITED
                    whose registered office is at 15 Stanhope Gate, London W1K
                    1LN (hereinafter called “the Company”); 
	 	 
	(2)	JOHN SIMON PATTERSON of
                    15 Stanhope Gate, London W1K ILN, who was appointed a director
                    of AstraZeneca PLC with effect from 1 January 2005 (hereinafter
                    called “the Executive”); and 
	 	 
	(3)	ASTRAZENECA PLC whose registered
                    office is at 15 Stanhope Gate, London W1K 1LN (hereinafter
                    called “AstraZeneca”). 

 WHEREAS

	 (A)	 The Company has agreed
                    to employ the Executive. 
	 
	 (B)	 AstraZeneca is a party
                    to this Agreement in order to take the benefit of certain
                    undertakings of the Executive. 
	 

NOW IT IS AGREED as follows:-
	 	 	 
	INTERPRETATION 
	 	 
	 1.	 In this Agreement:- 
	 
	 	 (A)	 the headings are for ease
                    of reference only and should be ignored when construing the
                    terms of this Agreement; 
	 
	 	 (B)	 the following words have
                    the respective meanings set alongside them 
	 

 

     

     -2- 

	 	 	(i) 	“Board”	 	means the Board of Directors
                    of the Company as the same may be constituted from time to
                    time or such other person or persons as the Board of Directors
                    may nominate as the representative of the Board of Directors
                    for the purpose of this Agreement; 
	 	 	 	 	 	 
	 	 	(ii)	“Employment”	 	means the employment established
                    by this Agreement; 
	 	 	 	 	 	 
	 	 	(iii)	“Group”	 	means the Company, the
                    Company’s Holding Company and any Subsidiary for the
                    time being of the Company; 
	 	 	 	 	 	 
	 	 	(iv) 	“Holding Company”	 	has the meaning given in
                    the Companies Act 1985; 
	 	 	 	 	 	 
	 	 	(v) 	“Subsidiary”	 	has the meaning given in
                    the Companies Act 1985;
	 	 	 	 	 	 
	 	 	(vi) 	“AstraZeneca
                    Board”	 	means the Board of Directors
                    of AstraZeneca as the same may be constituted from time to
                    time or such other person or persons as the Board of Directors
                    of AstraZeneca may nominate as the Board of Directors for
                    the purpose of this Agreement.

 

 -3-

 THE EMPLOYMENT 

	2. 	 	The Company
                    agrees to employ the Executive and the Executive agrees to
                    serve the Company and the Group in a senior executive capacity
                    and as a director of AstraZeneca.
	 	 	 
	DURATION
                              OF EMPLOYMENT
	 	 	 
	3.	(A)	Employment under this
                    Agreement shall be deemed to commence with effect from 1
                    January 2005. The Executive’s period of continuous employment
                    for statutory purposes began on 1 June 1975. Employment shall
                    continue (unless previously terminated under the provisions
                    of Clause 8 hereof) until terminated by either the Company
                    giving to the Executive or the Executive giving to the Company
                    at any time not less than twelve months’ previous notice
                    in writing to that effect PROVIDED ALWAYS that as soon as
                    the Executive shall attain the age of sixty-two years the
                    Employment shall thereupon cease and determine unless the
                    Executive is requested by the Company to continue his service
                    thereafter and he consents thereto. It is the Company’s
                    expectation that if it terminates the Employment under the
                    provisions of this Clause 3(A) any liability for compensation
                    would be subject to mitigation but would be calculated on
                    the basis of one year’s base salary, target bonus and
                    other benefits. 
	 	 	 
	 	(B) 	Without prejudice to the
                    Executive’s obligation to give notice in accordance
                    with Clause 3(A) above, the Company shall be entitled (but
                    not obliged) at its election to accept such shorter period
                    of notice from the Executive as it considers appropriate,
                    subject to the Executive entering into such post employment
                    termination restrictions (including non-competition and non-solicitation
                    provisions) as the Company considers to be reasonably necessary
                    for the protection of the business and confidential information
                    of the Group. 

 

  

  

 

 -4-

DUTIES OF THE EXECUTIVE
	 	 	 	 
	4.	(A)	The Executive
                    undertakes to the Company and AstraZeneca that he shall during
                    the Employment:- 
	 	 	 	 
	 	 	(i) 	use his best
                    endeavours to promote the interests of the Group and will
                    (unless prevented by ill health or accident and except during
                    holidays permitted by this Agreement) devote the whole of
                    his working time and attention to his duties hereunder; 
	 	 	 	 
	 	 	(ii)	carry out
                    such duties compatible with his status in accordance with
                    such reasonable directions as may from time to time reasonably
                    be assigned to him by
                    the Board, or, by AstraZeneca Board, and each such Board
                    shall at any time during the period of the Employment have
                    the right to call on the Executive to accept responsibility
                    for some other branch of the Company’s affairs or those
                    of any other member of the Group either in substitution for
                    or in addition to that at present entrusted to him; and 
	 	 	 	 
	 	 	(iii)	accept such offices in
                    any member of the Group as may be reasonably required by
                    the Board or AstraZeneca Board.
	 	 	 	 
	 	(B)	The Executive
                    may be required to perform duties which are reasonable and
                    compatible with his status not only for the Company but also
                    for any other member of the Group but the Company shall remain
                    obliged to make the payments and provide or procure the benefits
                    which the Executive is entitled to receive under the provisions
                    of Clause 6 hereof.
	 	 	 	 
	 	(C)	The Executive
                    undertakes to the Company and AstraZeneca that he will not
                    except as a shareholder or debenture-holder in any public
                    or private company be engaged or interested either directly
                    or indirectly in any capacity in any other trade, business
                    or occupation and shall not without the consent of AstraZeneca, 

 

 

 -5-

	 	 	expressed
                    by resolution of the AstraZeneca Board, be entitled to hold
                    any external directorships (meaning directorships in non-Group
                    companies) or other offices. 
	 	 	 	 
	CONFIDENTIALITY 
	 	 	 	 
	5.	(A)	The
                    Executive undertakes to the Company and AstraZeneca that
                    he:- 
	 	 	 	 
	 	 	(i)	shall keep the secrets
                    of the Company and any other member of the Group and shall
                    not either during the Employment or at any time after the
                    termination thereof divulge any matters or things relating
                    to the business or interests of the Company or any other
                    member of the Group to any unauthorised person or utilise
                    any secret or confidential knowledge or information of the
                    Company or any other member of the Group acquired in consequence
                    of the Executive’s Employment or otherwise to the detriment
                    or prejudice of the Company or any other member of the Group;
                    and
	 	 	 	 
	 	 	(ii)	shall also keep the secrets
                    of any company, firm or person with which the Company or
                    any other member of the Group may at any time during the
                    Employment be in commercial or technical co-operation or
                    association and the Executive hereby expressly binds himself
                    both during the period of the Employment and at all times
                    after the termination thereof not to divulge any matters
                    or things relating to the businesses or interests of any
                    such company, firm or person to any unauthorised person nor
                    to utilise any secret or confidential knowledge or information
                    of any such company, firm or person acquired in consequence
                    of the Executive’s Employment or otherwise to the detriment
                    or prejudice of any such company, firm or person. 
	 	 	 	 
	 	(B) 	Since
                    the Executive may obtain in the course of his Employment
                    confidential information concerning any other member of the
                    Group he hereby agrees that he will at the request and cost
                    of the Company enter into a direct agreement or

 

 -6-

	 	 	undertaking
                    with anyisuch company whereby he will accept restrictions
                    and provisions corresponding to the restrictions and provisions
                    herein contained (or such of them as may be appropriate in
                    the circumstances) in relation to such information. 
	 	 	 
	 	(C) 	The obligations of the
                    Executive under this Clause shall continue to be fully binding
                    on the Executive notwithstanding the termination of the Employment. 
	 	 	 
	REMUNERATION,
                              BENEFITS, HOLIDAYS AND EXPENSES
	 	 	 
	6.	(A) 	By way of remuneration
                    for his services under this Agreement the Company shall for
                    the period from the commencement of Employment to 31 December
                    2005 pay to the Executive a salary at the rate of £470,000
                    per annum and thereafter during the period of Employment
                    at such rate of £470,000 or such higher rate as may
                    have been fixed from time to time by, or under the authority
                    of, the Board, such salary to be payable by monthly instalments
                    in arrears.
	 	 	 
	 	(B) 	Such salary shall be inclusive
                    of any other sums received as directors’ fees or other
                    remuneration (save as provided in this Agreement) from the
                    Company or any other member of the Group and to give effect
                    to this provision the Executive shall pay over or procure
                    to be paid over to the Company all such fees or other remuneration
                    received by him. 
	 	 	 
	 	(C) 	The Executive may retain
                    (if and so long as agreed by the Board) any fees or remuneration
                    which may be payable to him in respect of any external directorships
                    (meaning directorships in non-Group companies) and other
                    offices the holding of which has been authorised under Clause
                    4(C) hereof. 
	 	 	 
	 	(D) 	The Executive shall also
                    be entitled to participate during the Employment in such
                    performance-related bonus schemes and such share incentive
                    or option schemes, in accordance with the rules of any such
                    schemes as the AstraZeneca Board may

 

 -7-

	 	 	from time to time adopt
                    for directors (whether or not together with other employees)
                    of AstraZeneca. 
	 	 	 
	 	(E)	The Company
                    shall also pay to the Executive such sum as may from time
                    to time be determined by, or under the authority of, the
                    Board towards expenses which are personally incurred by him
                    on behalf of the Company and are not charged under Clause
                    6(F) below. 
	 	 	 
	 	(F)	The Company shall also
                    repay to the Executive his actual reasonable travelling,
                    hotel and other expenses incurred on the business of the
                    Company in connection with the Employment, it being a term
                    of this Agreement that the Executive shall make such journeys
                    (at home or abroad) on the Company’s business as he
                    may be reasonably required by the Company from time to time
                    to undertake. 
	 	 	 
	 	(G)	The Executive shall conform
                    to such hours of work as may from time to time reasonably
                    be required of him to carry out his duties to the satisfaction
                    of the Board. The Executive shall be entitled without loss
                    of remuneration to a core entitlement of 22 days’ holiday
                    in each year (in addition to English bank and other public
                    holidays), together with any such holiday as he might ‘purchase’ through
                    membership of the AZ Advantage scheme. 
	 	 	 
	 	(H)	During any period of absence
                    from work due to sickness, injury or incapacity (but without
                    prejudice to the provisions of Clause 8(A) below) there shall
                    be deducted from the remuneration of the Executive the amount
                    of income benefit which he is entitled to claim in consequence
                    of such sickness, injury or incapacity under any Social Security
                    or National Insurance Scheme as for the time being in force
                    in England and Wales. 
	 	 	 
	 	(I)	The Executive shall be
                    entitled during the Employment to continued membership of
                    the AstraZeneca Pension Fund or of such other pension scheme
                    providing substantially similar benefits as the Company nominates
                    subject to and in accordance with the rules of the scheme
                    in question as from time to time 

 

 -8-

	 	 	amended. Changes
                    in the rules of the scheme in question will be notified to
                    the Executive. Continued membership of and accrued rights
                    under the AstraZeneca Pension Fund will not be affected in
                    any way by the entering into of this Agreement. 
	 	 	 
	 	(J)	The Executive shall be
                    entitled during the Employment to such other benefits including
                    participation in AZ Advantage not inconsistent with the foregoing
                    and as may be appropriate for a person of the status of the
                    Executive as are provided to other UK based employees in
                    the Group. 
	 	 	 
	INTELLECTUAL
                              PROPERTY RIGHTS 
	 	 	 
	7.	(A)	If the Executive (whether
                    alone or with others) shall at any time during the period
                    of the Employment make an invention (whether or not patentable)
                    within the meaning of the Patents Act 1977 (hereinafter called “Invention”)
                    relating to the business of the Company or any other member
                    of the Group he shall promptly disclose to the Company full
                    details thereof to enable the Company promptly to assess
                    the Invention and whether in its opinion under the applicable
                    law the Invention is the property of the Company provided
                    that any Invention which does not belong to the Company shall
                    be treated as confidential by the Company
	 	 	 
	 	(B)	If any Invention belongs
                    to the Company the Executive shall consider himself as a
                    trustee for the Company in relation to each such Invention
                    and shall, at the request and expense of the Company, do
                    all things necessary to vest all right, title and interest
                    in any such Invention (and in any patent granted in connection
                    therewith) in the Company or its nominee absolutely as legal
                    and beneficial owner and to secure and preserve full patent
                    or other appropriate forms of protection therefor in any
                    part of the world.
	 	 	 
	 	(C)	If an Invention does not
                    belong to the Company, the Company shall have the right to
                    acquire for itself or its nominee the Executive’s rights
                    therein within three (3)
	 	 	 

 

 -9-

	 	 	months after
                    disclosure pursuant to sub-clause (A) of this Clause on fair
                    and reasonable terms to be agreed or in default of agreement
                    within one (1) month to be acquired at a price to be determined
                    by a single expert to be nominated in default of agreement,
                    at the request of either the Company or the Executive, by
                    the President for the time being of the Chartered Institute
                    of Patent Agents or in default by the Courts.
	 	 	 
	 	(D) 	If the Executive (whether
                    alone or with others) shall at any time during the period
                    of the Employment create or make any discovery, design or
                    other work (whether registrable or not and whether or not
                    a copyright work), other than an Invention or which is unconnected
                    with the Employment (hereinafter called “Works”),
                    the Executive shall forthwith disclose to the Company full
                    details thereof and shall consider himself as a trustee for
                    the Company in relation to all such Works. The Executive
                    shall at the request and expense of the Company execute and
                    do all instruments and things necessary to vest all right,
                    title and interest in and to any such Works in the Company
                    or its nominee absolutely as legal and beneficial owner. 
	 	 	 
	 	(E) 	In consideration of the
                    Company entering into this Agreement the Executive hereby
                    assigns to the Company by way of assignment of future copyright,
                    design and other proprietary rights if any for the full term
                    thereof throughout the world in respect of all copyright
                    works created or made by the Executive during the period
                    of the Employment (except only those copyright works created
                    or made by the Executive and unconnected with the Employment).
	 	 	 
	 	(F) 	The Executive shall not
                    except as provided in this Clause or as may be necessary
                    in the course of the Employment disclose or make use of any
                    Invention or Works which belongs to the Company or, unless
                    and until the Company’s right under sub-Clause (C) shall
                    have expired, any Invention falling within the terms of that
                    sub-Clause. 

 

 -10-

	 	(G) 	The Executive
                    shall give notice in writing to the Company promptly on becoming
                    aware of any infringement or suspected infringement of any
                    intellectual property right in any Invention or Works. 
	 	 	 
	 	(H) 	The Executive shall not
                    do or fail to do any act which would or might prejudice the
                    rights of the Company under this Clause. 
	 	 	 
	 	(I) 	Rights and obligations
                    under this Clause shall continue in force after the termination
                    of the Employment in respect of each Invention and Works
                    and shall be binding upon the representatives of the Executive. 
	 	 	 
	 	(J) 	The Executive hereby irrevocably
                    waives any rights the Executive may have under Chapter IV (moral
                    rights) of Part I of the Copyright, Designs and Patents Act
                    1988 and any foreign corresponding rights in respect of all
                    Works. 
	 	 	 
	 	(K) 	The Executive HEREBY IRREVOCABLY
                    APPOINTS the Company to be his Attorney in his name and on
                    his behalf to execute and do any such instrument or thing
                    as may be desirable and generally to use his name for the
                    purpose of giving to the Company (or its nominee) the full
                    benefit of the provisions of this Clause or of the Company’s
                    entitlement under statute and in favour of any third party
                    a certificate in writing signed by any director or the secretary
                    of the Company that any instrument or act falls within the
                    authority hereby conferred shall be conclusive evidence that
                    such is the case.
	 	 	 
	TERMINATION 
	 	 	 
	8.	(A)	If the Executive shall
                    by reason of illness be unable to carry out his duties under
                    this Agreement for any time in excess of twelve calendar
                    months during any period of eighteen calendar months of his
                    service under this Agreement the Company shall be at liberty
                    on written notice to the Executive and on payment to him
                    of three months’ salary to terminate forthwith the Employment. 
	 	 	 

 

 -11-

	 	 (B)	 Notwithstanding any other
                    provision of this Agreement, the Company shall (without prejudice
                    to the other rights and remedies of the Company) be entitled
                    to terminate the Employment forthwith if the Executive:-
	 
	 	 	 (i)	 commits any serious or
                    persistent breach of his obligations under this Agreement
                    or is guilty of any gross default or gross misconduct in
                    connection with or affecting the business of the Company
                    or any other member of the Group or conducts himself (whether
                    or not in connection with the Employment) in a manner materially
                    prejudicial to the Company or any other member of the Group
                    or is guilty of conduct tending to bring himself or the Company
                    or another member of the Group into material disrepute; or 
	 
	 	 	 (ii)	 is guilty of dishonesty
                    whether or not in connection with the Employment which indicates
                    the Executive is not suitable for the Employment; or 
	 
	 	 	 (iii)	 commits a breach of any
                    legislation in force from time to time which may have a material
                    adverse effect on the business or reputation of the Company
                    or another member of the Group; or 
	 
	 	 	 (iv)	 becomes of unsound mind,
                    is bankrupted or has a receiving order made against him or
                    makes any general composition with his creditors or takes
                    advantage of any statute for the time being in force affording
                    relief for insolvent debtors; or 
	 
	 	 	 (v)	 becomes prohibited by
                    law from being a director of a company 
	 
	 	 	 	 whereupon the Executive
                    shall have no claim against the Company or AstraZeneca for
                    damages or otherwise by reason of such termination. 
	 

 

 -12-

	EVENTS UPON TERMINATION
	 	 
	 9.	 Upon the termination of
                    the Employment howsoever occasioned the Executive shall forthwith:- 
	 
	 	 (a)	 deliver on the request
                    of the Company or AstraZeneca to the Company or (as the case
                    may be) AstraZeneca (i) all documents and other materials
                    of whatsoever nature whether originals or copies made or
                    compiled by or delivered to the Executive during the period
                    of the employment (or any previous employment with Imperial
                    Chemical Industries PLC or successor companies) and concerning
                    the business, organisation, transactions, accounts, finances
                    or affairs of the Company or another member of the Group
                    and the Executive shall not retain any copies except such
                    as he may reasonably require in respect of any dispute or
                    anticipated dispute he may have with a member of the Group;
                    and (ii) return to the Company all other property of the
                    Company or (as the case may be) of any other member of the
                    Group (including any motor car made available to the Executive
                    which shall be returned in good condition (fair wear and
                    tear excepted)) in the possession or under the control of
                    the Executive; and 
	 
	 	 (b)	 at any time or from time
                    to time thereafter upon the request of the Company or AstraZeneca,
                    resign without claim for compensation from office as a director
                    of the Company and all other offices held by him in any other
                    member of the Group (without prejudice to any claim the Executive
                    may have for damages for breach of this Agreement) and should
                    he fail to do so the Company is hereby irrevocably authorised
                    to appoint some person in his name and on his behalf to sign
                    and do any documents or things necessary or requisite to
                    give effect thereto. 
	 

 

 -13-

	DIRECTORSHIP
	 	 	 
	10. 	If
                    the Executive ceases to be a director of AstraZeneca without
                    his consent, the Employment shall automatically determine
                    but without prejudice to any claim the Executive may have
                    for damages for breach of this Agreement. 
	 	 	 
	 	 	 
	NOTICES
	 	 	 
	11.	Notices
                    by any party hereto must be given by letter or facsimile
                    transmission (“fax”) addressed to the other parties
                    at (in the case of the Company and AstraZeneca) its registered
                    office for the time being and (in the case of the Executive)
                    his last known address and any such notice given by letter
                    (unless delivered by hand) or fax shall be deemed to have
                    been given at the time at which the letter or fax would be
                    delivered in the ordinary course of post or transmission
                    as the case may be.
	 	 	 
	 	 	 
	MISCELLANEOUS 
	 	 	 
	12.	(A)	The benefits and obligations
                    of this Agreement shall devolve upon the Company’s and
                    AstraZeneca’s successors in business and assigns.
	 	 	 
	 	(B) 	The expiration or determination
                    of the Employment howsoever arising shall not operate to
                    affect such of the provisions hereof as in accordance with
                    their terms are expressed to operate or have effect thereafter. 

 

 -14-

 IN WITNESS whereof this Agreement has been duly
          executed as a Deed the day and year first above written. 

	 	 	 	 
	SIGNED
                    AND DELIVERED as a Deed by	}	 
	ASTRAZENECA
                    UK LIMITED 	}	 
	acting
                    by 	}	 
	a
                    Director and 	}	 
	the
                    Secretary 	}	 
	 	 	 
	 	 	 	 
	SIGNED
                    AND DELIVERED as a Deed by	}	 
	JOHN
                    SIMON PATTERSON 	}	 
	in
                    the presence of:-	}	 
	 	 	 
	 	 	 
	Name:	/s/
                    D. Alan-Smith 	 	 
	 	
	 	 
	 	Dinah Alan-Smith 	 	 
	Address:	c/o
                    15 Stanhope Gate 	 	 
	 	London	 	 
	 	W1K 1LN 	 	 
	 	 	 	 
	Occupation:	PA	 	 
	 	 	 	 
	SIGNED
                    AND DELIVERED as a Deed 	}	 
	by ASTRAZENECA
                    PLC	}	 
	acting
                    by 	}	 
	a
                    Director and 	}	 
	the
                    Secretary 	}EXHIBIT 4.5

Dated 16 December 2005 

 

 

ASTRAZENECA UK LIMITED (1)

ASTRAZENECA PLC (2)

DAVID BRENNAN (3) 

 

SERVICE AGREEMENT

 

Contents 

	 	 	
Clause	 	
Page
	 
	 1	 	
Definitions and interpretation	 	
1
	 2	 	
Appointment	 	
2
	 3	 	
Duration of the Employment	 	
2
	 4	 	
Scope of the Employment	 	
3
	 5	 	
Hours of work	 	
4
	 6	 	
Place of work	 	
4
	 7	 	
Remuneration	 	
4
	 8	 	
Expenses	 	
4
	 9	 	
Holidays	 	
4
	 10	 	
Sickness benefits	 	
      5
	 11	 	
Pension, death benefit and medical insurance	 	
6
	 12	 	
Restrictions during the Employment	 	
6
	 13	 	
Confidential information and company documents	 	
7
	 14	 	
Inventions and other intellectual property	 	
7
	 15	 	
Termination	 	
8
	 16	 	
Restrictive covenants 	 	
10
	 17	 	
Disciplinary and grievance procedures	 	
11
	 18	 	
Notices	 	
11
	 19	 	
Former contracts of employment	 	
11
	 20	 	
Choice of law and submission to jurisdiction	 	
12
	 21	 	
General	 	
12

This Agreement is made on 16 December 2005

Between 

	
(1)  	
ASTRAZENECA UK LIMITED (registered in England and Wales under number 3674842) whose registered office is at 15 Stanhope Gate, London, W1K 1LN (Company); and
	 
	
(2)	
ASTRAZENECA PLC (registered in England and Wales under number 2723534) whose registered office is at 15 Stanhope Gate, London, W1K 1LN (AstraZeneca); and
	 
	
(3)	
DAVID R BRENNAN of 15 Stanhope Gate, London W1K 1LN (Executive)

It is agreed

	
1     	
      Definitions and interpretation
	 
	
1.1  	
In this Agreement unless the context otherwise requires the following expressions have the following meanings:
	 
	 	
AstraZeneca Board means the Board of Directors of AstraZeneca as the same may be constituted from time to time or such other person or persons as the Board of Directors of AstraZeneca
may nominate as the representative of the Board of Directors for this purpose.
	 
	 	
Board means Board of Directors of the Company as the same may be constituted from time to time or such other person or persons as the Board of Directors of the Company may nominate as
the representative of the Board of Directors for this purpose.
	 
	 	
Confidential Information means information relating to the business, products, affairs and finances of the Company or of any Group Company for the time being confidential to it or to
them and trade secrets (including, without limitation, technical data and know-how) relating to the business of the Company or of any Group Company or of any of its or their suppliers, clients or customers including in particular (by way of example
only and without limitation), customer requirements, prices charged to and terms of business with customers, terms of business with suppliers, marketing plans and sales forecasts, financial information, results and other forecasts (save to the
extent that these are included in published audited accounts), any proposals relating to the acquisition or disposal of a company, or a business or any part thereof or to any proposed expansion or contraction of activities, details of employees and
officers and of the remuneration and other benefits paid to them, information relating to research activities, inventions, secret processes, designs, formulae and product lines, any information which is treated as confidential or which the Executive
is told or ought reasonably to know is confidential and any information which has been given to the Company or any Group Company in confidence by customers, suppliers and others.
	 
	 	
Employment means the Executive's employment under this Agreement
	 
	 	
ERA means the Employment Rights Act 1996 as amended
	 
	 	
Group means the Company and the Group Companies
	 
	 	
Group Company means any company which is for the time being a subsidiary or holding company of the Company and any subsidiary of any such holding company and for the purposes of this
Agreement the terms subsidiary and holding company shall have the meanings ascribed to them by sections 736 and 736A Companies Act 1985 (and Group Companies shall be interpreted accordingly)

1

	   	 Intellectual Property means
        all patents, registered designs, trade marks and service marks (whether registered or not and including any applications for the foregoing), copyrights, design rights, semiconductor topography rights, database rights
        and all other intellectual property and similar proprietary rights subsisting in any part of the world (whether or not capable of registration) and including (without limitation) all such rights in materials, works,
        prototypes, inventions, discoveries, techniques, computer programs, source codes, data, technical, commercial or confidential information, trading, business or brand names, goodwill or the style of presentation of the goods
        or services or any improvement of any of the foregoing and the right to apply for registration or protection of any of them and in existing applications for the protection of any of the above
	 
	   	 Salary means the salary referred to in clause 7.1 
	 
	 	Sensitive Data means personal data consisting of information as to racial or ethnic origin; political opinions; religious beliefs or other beliefs of a similar nature; membership of a trade union (within the meaning of the Trade Union and Labour Relations (Consolidation) Act 1992); physical or mental health or condition; sexual life; the commission or alleged commission of any offence or any proceedings for any offence committed or alleged to have been committed, including the disposal of such proceedings or the sentence of any court in such proceedings 
	 
	 	Termination Date means the date of the termination of the Employment or, where the Company exercises its rights under clause 3.3 to require the Executive to remain at home, the last day on which the Executive was required to work 
	 	 
	1.2  	References to clauses and schedules are unless otherwise stated to clauses of and schedules to this Agreement. 
	 	 
	1.3	The headings to the clauses are for convenience only and shall not affect the construction or interpretation of this Agreement. 
	 	 
	2	Appointment
	 	 
	2.1	The Company agrees to employ the Executive and the Executive agrees to act in a senior executive capacity in the Company and as Chief Executive Officer of AstraZeneca on the terms of this Agreement. 
	 	 
	3	Duration of the Employment
	 	 
	3.1	The Employment shall commence on 1 January 2006 and, subject to the provisions of this Agreement, shall continue unless and until terminated by either party giving to the other not less than 12 months' notice in writing. 
	 	 
	3.2	Notwithstanding clause 3.1, the Employment shall automatically terminate when the Executive reaches the normal retiring age from time to time applicable to executives of the Company, currently being the age of 62. 
	 	 
	3.3	At any time during any period of notice of termination served in accordance with clause 3.1 (whether given by the Company or the Executive), the Company shall have the right at its absolute discretion to assign no, reduced or alternative duties to the Executive and shall be entitled to require the Executive to act at the direction of the Company including the right to exclude him from its premises, and/or remove him from office as a director of the Company and from any or all offices held by him in the Company or in any other company in the Group (including if appropriate the office of trustee of any of the pension schemes of the Company or

2

	 	the Group) and/or prevent the Executive from discussing its affairs with the Company's or any other company in the Group's employees, agents, clients, customers. If the Company shall exercise its right under this clause, the Executive's entitlement to Salary and other contractual benefits shall continue, subject always to the rules of any relevant scheme or policy relating to such benefits. For the avoidance of doubt, at all times during any period of notice of termination served in accordance with clause 3.1 (whether given by the Company or the Executive), the Executive shall continue to be bound by the same obligations as were owed to the Company prior to the commencement of the notice period.
	 	 
	3.4  	For the purposes of the ERA the Executive's period of continuous employment began on 16 June 1975. 
	 	 
	3.5	For the avoidance of doubt, in the event that the Company terminates the Employment without notice or on notice less than required by with clause 3.1 the Executive's entitlement to any damages or compensation arising from the termination will be subject to the Executive's duty to mitigate his losses. 
	 	 
	3.6	Upon termination of this Agreement for whatever reason the Company shall pay ail reasonable costs of relocation for the Executive and his family back to the US. 
	 	 
	4	Scope of the Employment 
	 	 
	4.1	During the Employment the Executive shall:

	 	
(a)  	
devote the whole of his time, attention and skill to the business and affairs of the Group during the hours of work described in clause 5 except during holidays and periods of absence
due to ill health;
	 
	 	
(b)	
faithfully, competently and diligently perform such duties and exercise such powers consistent with his position as may from time to time be assigned to or vested in him by the Board or
the AstraZeneca Board;
	 
	 	
(c)	
obey the reasonable and lawful directions of the Board and the AstraZeneca Board;
	 
	 	
(d)	
comply with all the Company's and AstraZeneca's rules, regulations, policies and procedures from time to time in force; and
	 
	 	
(e)	
keep the Board and the AstraZeneca Board at all times promptly and fully informed (in writing if so requested) of his conduct of the business of AstraZeneca, the Company and any Group
Company and provide such explanations in connection with it as the Board and the AstraZeneca Board may require.

	4.2  	The Executive shall if and so long as the Company requires and without any further remuneration carry out his duties on behalf of any Group Company and act as a director or officer of any Group Company. 
	 	 
	4.3	The Company may at its sole discretion transfer this Agreement to any Group Company at any time. 
	 	 
	4.4	If at any time the Executive is unable to perform his duties properly because of ill health, accident or otherwise, or becomes incapable by reason of mental disorder of administering his property or managing his affairs, then the Company or AstraZeneca may appoint any other person or persons to act jointly with the Executive in any position to which he may be assigned from time to time. 

3

 

	4.5  	For the purposes of the Data Protection Act 1998, the Executive consents to the Company's processing of personal data, including Sensitive Data, of which the Executive is the subject details of which are specified in the Company's Data Protection Policy
	 	 
	5	Hours of work
	 	 
	 	The Executive shall be required to work a minimum of 40 hours per week at such times to be agreed between the Executive and the Company which may involve working during normal business hours and during such additional hours as are necessary for the proper performance of his duties or as the Board may reasonably require from time to time.
	 	 
	6	Place of work
	 	 
	6.1	The Executive's place of work will initially be the Company's offices at Stanhope Gate. 
	 	 
	6.2	The AstraZeneca Board shall have the right to require the Executive to move house to an appropriate location for the better performance of his duties. The Executive will be given reasonable notice of any such requirement and the Company will reimburse to him all expenses incurred by him in such a move as it may consider reasonable in all the circumstances in accordance with its Relocation Policy from time to time in force. 
	 	 
	7	Remuneration
	 	 
	7.1	The Company shall pay to the Executive the Salary at the rate of £870,000 per annum, by credit transfer to his bank account payable by equal monthly instalments in arrears (or such other sum as may from time to time be agreed). The rate of Salary will be reviewed annually in December, the first such review to take place in December 2006. 
	 	 
	7.2	The Executive shall also be entitled to participate during the Employment in such performance related bonus schemes and such share incentive or option schemes, in accordance with the rules of any such schemes from time to time in force, as the AstraZeneca Board may in its discretion determine. If the Company shall pay the Executive a bonus in any one year, this shall not give rise to a contractual entitlement to a bonus in future years. 
	 	 
	7.3	The Salary and bonus/share incentives/share options shall be inclusive of any fees to which the Executive may be entitled as a director of the Company or any Group Company.
	 	 
	7.4	Payment of the Salary and bonus/share incentives/share options to the Executive shall be made either by the Company or by a Group Company and, if by more than one company, in such proportions as the Board or the AstraZeneca Board may from time to time think fit. 
	 	 
	7.5	The Company shall be entitled to deduct from any sum due to the Executive under the terms of this Agreement any monies which are owed by the Executive to the Company.
	 	 
	8	Expenses
	 	 
	8.1	The Company shall reimburse the Executive in respect of all expenses reasonably incurred by him in the proper performance of his duties, subject to his providing such receipts or other appropriate evidence as the Company may require. 
	 	 
	9	Holidays
	 	 
	9.1	The Executive shall be entitled, in addition to all Bank and Public holidays normally observed in England to 30 working days' paid holiday in each year. The Executive may take his holiday at such times as are agreed with the Chairman. 

4

	
9.2  	
In the respective holiday years in which the Employment commences or terminates, the Executive's entitlement to hoiiday shall accrue on a pro rata basis for each completed calendar
month of service during the relevant year.
	 
	
9.3 	
If, on the termination of the Employment, the Executive has exceeded his accrued holiday entitlement, the value of such excess, calculated by reference to clause 9.2 and the Salary, may
be deducted by the Company from any sums due to him. If the Executive has any unused holiday entitlement, the Company shall at its discretion either require the Executive to take such unused holiday during any notice period or make a payment to him
in lieu of it, calculated in accordance with clause 9.2.
	 
	
9.4 	
Holiday entitlement for one holiday year cannot be taken in subsequent holiday years unless otherwise agreed by the AstraZeneca Board. Failure to take holiday entitlement in the
appropriate holiday year will lead to forfeiture of any accrued holiday not taken without any right to payment in lieu of it.
	 
	
10     	
Sickness benefits
	 
	
10.1 	
Subject to clause 15 the Company shall continue to pay the Salary for:
	 
	 	
(a)  	
up to a maximum of 130 working days' absence on medical grounds in any period of 12 calendar months; or
	 
	 	
(b)	
for the first 130 working days' absence on medical grounds in any one continuous period of absence (or two or more linked periods as determined by the Social Security Contributions and
Benefits Act 1992, as amended from time to time)
	 
	 	
whichever is the lesser, provided that the Executive shall from time to time if required supply the Company with medical certificates covering any period of sickness or incapacity
exceeding seven days (including weekends).
	 
	
10.2	
Payment in respect of any other or further period of absence shall be at the Company's discretion.
	 
	
10.3	
Any payment to the Executive pursuant to clause 10.1 shall be subject to set off by the Company in respect of any Statutory Sick Pay and any Social Security Sickness Benefit or other
benefits to which the Executive may be entitled.
	 
	
10.4	
Subject to clause 10.2, when all sick pay entitlement pursuant to clause 10.1 has been exhausted, no further salary will be payable by the Company to the Executive until the Executive
has returned to active service of the Company.
	 
	
10.5	
If the Executive's absence shall be occasioned by the actionable negligence of a third party in respect of which damages are recoverable, then the Executive shall:
	 
	 	
(a)  	
notify the Company immediately of all the relevant circumstances and of any claim, compromise, settlement or judgment made or awarded in connection with it;
	 
	 	
(b)	
give to the Company such information concerning the above matters as the Company may reasonably require; and
	 
	 	
(c)	
if the Company so requires, refund to the Company any amount received by him from any such third party provided that the refund shall be no more than the amount which he has recovered
in respect of remuneration.

5

	11	Pension, death benefit and medical insurance
	 	 
	 11.1  	 During the Employment the Executive shall be entitled to participate in the following plans subject to their rules from time to time in force: 
	 
	 	(a)  	AstraZeneca Defined Benefit Pension Plan;
	 	 	 
	 	(b)	AstraZeneca Savings and Security Plan;
	 	 	 
	 	(c)	AstraZeneca Supplemental Retirement Plan;
	 	 	 
	 	(d)	AstraZeneca PLC Executive Deferral Plan; 
	 	 	 
	 	(e)	AstraZeneca PLC Executive Deferred Compensation Plan;
	 	 	 
	 	(f)	AstraZeneca Medical Plan (eligible upon retirement);
	 	 	 
	 	(g)	AstraZeneca Dental Plan;
	 	 	 
	 	(h)	AstraZeneca Flexible Spending Account (Healthcare);
	 	 	 
	 	(i)	AstraZeneca Vision Plan;
	 	 	 
	 	(j)	AstraZeneca Life and AD&D Insurance Plan;
	 	 	 
	 	(k)	AstraZeneca Short-Term Disability Policy;
	 	 	 
	 	(l)	AstraZeneca Long-Term Disability Policy; 
	 	 	 
	 	provided that the Plans or Policies may be terminated or amended at any time in accordance with the relevant trust deed or rules that govern them. [The Company or AstraZeneca will not be required to provide a replacement plan, policy or compensation if the any of the Plans or Policies are terminated.] 
	 	 	 
	11.2	The Company shall, from time to time, be entitled to require the Executive to undertake a medical examination. 
	 	 	 
	11.3	The Executive shall be entitled during the Employment to such other benefits not inconsistent with the foregoing and as may be appropriate for a person of the status of the Executive as are provided to other UK based employees in the Group. 
	 	 	 
	12	Restrictions during the Employment
	 	 	 
	12.1	During the Employment the Executive shall not directly or indirectly be employed, engaged, concerned or interested:
	 	 	 
	 	(a)  	in any other business or undertaking; or
	 	 	 
	 	(b)	in any activity which the AstraZeneca Board reasonably considers may be, or become, harmful to the interests of AstraZeneca, the Company or of any Group Company or which might reasonably be considered to interfere with the performance of the Executive's duties under this Agreement.
	 	 	 
	12.2	Clause 12.1 shall not apply:

6

	 	
(a)  	
to the Executive holding (directly or through nominees) investments listed on the Official List of London Stock Exchange plc or in respect of which dealing takes place in the
Alternative Investment Market or any recognised stock exchange as long as he does not hold more than 5 per cent of the issued shares or other securities of any class of any one company; or
	 
	 	
(b)	
to any act undertaken by the Executive with the prior written consent of the AstraZeneca Board.
	 
	
12.3  	
The Executive shall comply with every rule of law, the UK Listing Authority's listing rules' Model Code for transactions in securities by directors of listed companies, certain
employees and persons connected with them and every regulation of AstraZeneca and the Company for the time being in force in relation to dealings in shares or other securities of AstraZeneca, the Company or any Group Company.
	 
	
13     	
Confidential information and company documents
	 
	
13.1	
The Executive shall neither during the Employment (except in the proper performance of his duties or with the express written consent of the Board) nor at any time (without limit) after
the termination of the Employment except in compliance with an order of a competent court:
	 
	 	
(a)  	
divulge or communicate to any person, company, business entity or other organisation;
	 
	 	
(b)	
use for his own purposes or for any purposes other than those of the Company or any Group Company; or
	 
	 	
(c)	
through any failure to exercise due care and diligence, permit or cause any unauthorised disclosure of 
	 
	 	any Confidential Information. These restrictions shall cease to apply to any information which shall become available to the public generally otherwise than through any breach by the Executive of the provisions of this Agreement or other default of the Executive.
	 
	
13.2	
The Executive acknowledges that all books, notes, memoranda, records, lists of customers and suppliers and employees, correspondence, documents, computer and other discs and tapes, data
listings, codes, designs and drawings and other documents and material whatsoever (whether made or created by the Executive or otherwise) relating to the business of AstraZeneca, the Company or any Group Company (and any copies of the
same):
	 
	 	
(a)  	
shall be and remain the property of AstraZeneca, the Company or the relevant Group Company; and
	 
	 	
(b)	
shall be handed over by the Executive to AstraZeneca, the Company or to the relevant Group Company on demand and in any event on the termination of the Employment and the Executive
shall certify that all such property has been handed over on request by the AstraZeneca Board.
	 
	
14     	
Inventions and other intellectual property
	 
	
14.1	
The parties foresee that the Executive may make inventions or create other Intellectual Property in the course of his duties and agree that in this respect the Executive has a special
responsibility to further the interests of AstraZeneca, the Company and any Group Company.

7

	
14.2  	
Any invention, improvement, design, process, information, copyright work, computer program, trade mark, trade name or get-up, work or other output (Work) made, created or discovered by
the Executive during the Employment (whether capable of being patented or registered or not and whether or not made or discovered in the course of the Employment) in conjunction with or in any way affecting or relating to the business of the Company
or of any Group Company or capable of being used or adapted for use in or in connection with such business, together with all lntellectual Property subsisting therein, (collectively lntellectual Property Rights) shall be disclosed immediately to the Company and shall (subject to sections 39 to 43 Patents Act 1977) belong to and
be the absolute property of the Company or such Group Company as the Company may direct and the Executive hereby assigns to the Company with full title guarantee and by way of present assignment of future rights, ail such copyright, database rights,
design rights (and any other lntellectual Property capable of assignment by way of present assignment of future rights) which may fall within the definition of the lntellectual Property Rights absolutely for the full term of those
rights.
	 
	
14.3	
If and whenever required so to do by the Company the Executive shall at the expense of the Company or such Group Company as the Company may direct:
	 
	 	
(a)  	
apply or join with the Company or such Group Company in applying for patent or other protection or registration in the United Kingdom and in any other part of the world for any
lntellectual Property Rights; and
	 
	 	
(b)	
execute all instruments and do all things necessary for vesting all lntellectual Property Rights (including such patent or other protection or registration when so obtained) and all
right, title and interest to and in them absolutely, with full title guarantee and as sole beneficial owner, in the Company or such Group Company or in such other person as the Company may specify.
	 
	
14.4	
The Executive irrevocably and unconditionally waives all rights under Chapter IV of Part I Copyright Designs and Patents Act 1988 in connection with his authorship of any existing or
future copyright work in the course of the Employment, in whatever part of the world such rights may be enforceable including, without limitation:
	 
	 	
(a)	
the right conferred by section 77 of that Act to be identified as the author of any such work; and
	 
	 	
(b)	
the right conferred by section 80 of that Act not to have any such work subjected to derogatory treatment.
	 
	
14.5	
The Executive irrevocably appoints the Company to be his Attorney in his name and on his behalf to execute any such instrument or do any such thing and generally to use his name for the
purpose of giving to the Company the full benefits of this clause A certificate in writing in favour of any third party signed by any director or by the Secretary of the Company that any instrument or act falls within the authority conferred by this
Agreement shall be conclusive evidence that such is the case.
	 
	
14.6	
Nothing in this clause 14 shall be construed as restricting the rights of the Executive or the Company under sections 39 to 43 Patents Act 1977.
	 
	
15	
Termination
	 
	
15.1	
Notwithstanding any other provisions of this Agreement, in any of the following circumstances the Company may terminate the Employment summarily by serving written notice on the
Executive to that effect. In such event the Executive shall not be entitled to any further

8

	 	payment from the Company except such sums as shall have accrued due at the date of service of such notice. The circumstances are if the Executive: 
	 	 	 
	 	 (a)  	 commits any serious breach of this Agreement or is guilty of any gross misconduct, gross incompetence, or any wilful neglect in the discharge of his duties; 
	 
	 	(b)	is guilty of any fraud, dishonesty or conduct tending to bring himself, the Company or any Group Company into disrepute; 
	 	 	 
	 	(c)	commits any act of bankruptcy or takes advantage of any statute for the time being in force offering relief for insolvent debtors; 
	 	 	 
	 	(d)	is convicted of any criminal offence (other than minor offences under the Road Traffic Acts or the Road Safety Acts for which a fine or non-custodial penalty is imposed) which might reasonably be thought to affect adversely the performance of his duties; 
	 	 	 
	 	(e)	is disqualified from holding office in the Company or in any other company by reason of any order made under the Company Directors Disqualification Act 1986 or any other enactment; 
	 	 	 
	 	 (f)	resigns as or otherwise ceases to be or becomes prohibited by law from being a director of the Company or AstraZeneca, otherwise than at the Company's or Astrazeneca's request.  
	 
	 	Any delay by the Company in exercising such right of termination shall not constitute a waiver of it. 
	 	 
	15.2  	If at any time the Executive is unable to perform his duties properly because of ill health accident or otherwise for a period or periods totalling at least 130 working days in any period of 12 calendar months, or becomes incapable by reason of mental disorder of managing and administering his property and affairs, then the Company may, notwithstanding the existence of any permanent health insurance cover provided for the Executive under clause 11.1 above, in its absolute discretion terminate the Employment by giving him not less than three months' written notice to that effect. 
	 	 
	15.3	If the Company believes that it may be entitled to terminate the Employment, whether pursuant to clause 15.1 or otherwise, it shall be entitled (but without prejudice to its right subsequently to terminate the Employment on the same or any other ground) to suspend the Executive on full pay for so long as it may think fit. 
	 	 
	 15.4	On the termination of the Employment or upon the Company having exercised its rights under clause 3.3, the Executive shall:  
	 
	 	 (a)	 at the request of the AstraZeneca Board or the Company resign from office as a director of the Company and all offices held by him in any Group Company and shall transfer to the Company without payment or as the Company may direct any qualifying shares held by him as nominee for the Company provided however that such resignation shall be without prejudice to any claims which the Executive may have against the Company or any Group Company arising out of the termination of the Employment; and 
	 
	 	 (b)	immediately deliver to the Company all materials within the scope of clause 13.2,
any Company car, mobile telephone or other Company equipment in his possession and all keys, credit cards, and other property of or relating to the business of the 

9

	 	 
	Company or of any Group Company which may be in his possession or under his power or control
	 
	 	
and the Executive irrevocably authorises the Company to appoint any person in his name and on his behalf to sign any documents and do any things necessary or requisite to give effect to
his obligations under this clause 15.4.
	 
	
16	
Restrictive covenants
	 
	
16.1  	
The Executive will not (without the previous consent in writing of the AstraZeneca Board) for the period of 12 months immediately after the Termination Date whether as principal or
agent, and whether alone or jointly with, or as a director, manager, partner, shareholder, employee or consultant of any other person, directly or indirectly:
	 
	 	
(a)  	
carry on, or be engaged, concerned or interested in any business which is similar to and competes with any business being carried on by the Company or by any Group Company at the
Termination Date and with which the Executive was involved in the course of the Employment at any time during the period of 12 months immediately preceding the Termination Date;
	 
	 	
(b)	
negotiate with, solicit business from or endeavour to entice away from AstraZeneca, the Company or any Group Company the business of any person, firm, company or organisation who or
which to his knowledge is and has been a customer, client or agent of or supplier to (or who had regular business dealings with AstraZeneca, the Company or with any Group Company) during the period of 12 months immediately preceding the Termination
Date and with whom he had direct or indirect dealings or personal contact in the course of the Employment during that period, so as to harm the goodwill or otherwise damage the business of AstraZeneca, the Company or of any other Group Company
provided that this restriction will be limited to activities by the Executive which will involve offering or providing services similar to those which he will have provided during the Employment;
	 
	 	
(c)	
undertake to provide in competition with AstraZeneca, the Company or any Group Company any service or manufacture or supply any product similar to those with which he was concerned in
the course of the Employment during the period of 12 months immediately preceding the Termination Date to or for any person who is or was a customer, client or agent of or supplier to (or who had regular business dealings with) AstraZeneca, the
Company or any other Group Company during the period of 12 months immediately preceding the Termination Date and with whom he had direct or indirect dealings in the course of the Employment during that period;
	 
	 	
(d)	
interfere with, solicit or endeavour to entice away from AstraZeneca, the Company or any Group Company any person who to his knowledge is, and within the period of 12 months immediately
preceding the Termination Date had been, part of the senior management of AstraZeneca, the Company or any other Group Company and with whom he had personal dealings in the course of the Employment during that period.
	 

	
16.2  	
For the avoidance of doubt, none of the restrictions contained in clause 16.1 shall prohibit any activities by the Executive which are not in direct or indirect competition with any
business being carried on by AstraZeneca, the Company or any Group Company at the Termination Date.
	 
	
16.3	
Nothing in clause 16.1 shall preclude the Executive from holding (directly or through nominees) investments listed on the Official List of London Stock Exchange plc or in
respect

10

	 	
of which dealing takes place in the Alternative Investment Market or any recognised stock exchange as long as he does not hold more than 5 per cent of the issued shares or other
securities of any class of any one company.
	 
	
16.4  	
At no time after the Termination Date shall the Executive directly or indirectly represent himself as being interested in or employed by or in any way connected with AstraZeneca, the
Company or any Group Company, other than as a shareholder and former employee of the Company.
	 
	
16.5	
The Executive agrees that, having regard to all the circumstances, the restrictions contained in this clause are reasonable and necessary for the protection of AstraZeneca, the Company
or of any Group Company and that they do not bear harshly upon him and the parties agree that:
	 
	 	
(a)  	
each restriction shall be read and construed independently of the other restrictions so that if one or more are found to be void or unenforceable as an unreasonable restraint of trade
or for any other reason the remaining restrictions shall not be affected; and
	 
	 	
(b)	
if any restriction is found to be void but would be valid and enforceable if some part of it were deleted, that restriction shall apply with such deletion as may be necessary to make it
valid and enforceable.
	 
	
17	
Disciplinary and grievance procedures
	 
	
17.1	
There are no special disciplinary or grievance rules which apply to the Executive and any such matters affecting him will be dealt with by the AstraZeneca Board.
	 
	
18	
Notices
	 
	
18.1	
Any notice or other document to be given under this Agreement shall be in writing and may be given personally to the Executive or to the Secretary of the Company or AstraZeneca (as the
case may be) or may be sent by first class post or other fast postal service or by facsimile transmission to, in the case of the Company, its registered office for the time being and in the case of the Executive either to his address shown on the
face of this Agreement or to his last known place of residence.
	 
	
18.2	
Any such notice shall (unless the contrary is proved) be deemed served when in the ordinary course of the means of transmission it would first be received by the addressee in normal
business hours. In the case of first class post, this shall be deemed to be no later than two working days after posting. In proving such service it shall be sufficient to prove, where appropriate, that the notice was addressed properly and posted,
or that the facsimile transmission was despatched.
	 
	
19	
Former contracts of employment
	 
	 	
This Agreement shall be in substitution for any previous contracts, whether by way of letters of appointment, agreements or arrangements, whether written, oral or implied, relating to
the employment of the Executive, which shall be deemed to have been terminated by mutual consent as from the date of this Agreement and the Executive acknowledges that he has no outstanding claims of any kind against AstraZeneca, the Company or any
Group Company in respect of any such contract (otherwise than in respect of remuneration and expenses accrued to 31 December 2005 but not yet paid).

11

	
20	
Choice of law and submission to jurisdiction
	 
	
20.1  	
This Agreement shall be governed by and interpreted in accordance with English law.
	 
	
20.2	
The parties submit to the exclusive jurisdiction of the English courts.
	 
	
21	
General
	 
	
21.1	
The expiration or termination of this Agreement shall not prejudice any claim which either party may have against the other in respect of any pre-existing breach of or contravention of
or non-compliance with any provision of this Agreement nor shall it prejudice the coming into force or the continuance in force of any provision of this Agreement which is expressly or by implication Intended to or has the effect of coming into or
continuing in force on or after such expiration or termination.
	 
	
21.2	
This Agreement constitutes the written statement of the terms of employment of the Executive provided in compliance with Part I of the ERA.
	 
	
21.3	
A person who is not a party to this Agreement has no right under the Contracts (Rights of Third Parties) Act 1999 to enforce any term of this Agreement but this does not affect any
right or remedy of a third party which exists or is available apart from that Act.

12

	
Executed as a deed by the Company

	 	)	 	/s/
              
	acting by two directors or by a director and its	 	)	 	

	secretary	 	)	 	Director
	 	 	 	 	 
	 	 	)	 	/s/ 
	 	 	)	 	

	 	 	 	 	Secretary
	 
	 	 	 	 	 
	
 Executed as a deed by AstraZeneca

 	 	)	 	/s/ 
	acting by two directors or by a director and its	 	)	 	

	secretary	 	)	 	Director
	 	 	 	 	 
	 	 	)	 	/s/ 
	 	 	)	 	

	 	 	 	 	Secretary
	 
	 
	
Executed as a deed by the Executive

	 	)	 	 
	in the presence of 	 	)	 	/s/ 
	 	 	)	 	

	 
	/s/ S.E.J. Howe	 	 	 	 
	

  	 	 	 	 
	
Signature of
witness	 	 	 	 
	 	 	 	 	 
	Name      Mrs S.E.J. Howe 	 	 	 	 
	 	 	 	 	 
	Address 15 Stanhope Gate 	 	 	 	 
	               London W1K 1LN	 	 	 	 
	 	 	 	 	 

13

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