SHB (유전자)

SH2 도메인 함유 어댑터 단백질 B(SH2 domain-containing adapter protein B)는 인간에서 SHB 유전자에 의해 암호화 된 단백질이다. SHB는 다음과 상호 작용하는 것으로 나타났다. EPS8 섬유아세포 성장 요소 수용체 1 활성 T 세포 링커 림프구 세포 단백질 2 PIK3R1 Src VAV1 ZAP-70 GRCh38: Ensembl release 89: ENSG00000107338 - 앙상블, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000044813 - 앙상블, May 2017 “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.  “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.  “The SHB adaptor protein maps to human chromosome 9”. 《Genomics》 24 (3): 615–7. Dec 1994. doi:10.1006/geno.1994.1681. PMID 7713524.  “Entrez Gene: SHB Src homology 2 domain containing adaptor protein B”.  Karlsson T, Songyang Z, Landgren E, Lavergne C, Di Fiore PP, Anafi M, Pawson T, Cantley LC, Claesson-Welsh L, Welsh M (Apr 1995). “Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins”. 《Oncogene》 10 (8): 1475–83. PMID 7537362.  Lindholm CK, Gylfe E, Zhang W, Samelson LE, Welsh M (Sep 1999). “Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells”. 《The Journal of Biological Chemistry》 274 (39): 28050–7. doi:10.1074/jbc.274.39.28050. PMID 10488157.  Lindholm CK, Henriksson ML, Hallberg B, Welsh M (Jul 2002). “Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells”. 《European Journal of Biochemistry / FEBS》 269 (13): 3279–88. doi:10.1046/j.1432-1033.2002.03008.x. PMID 12084069.  “Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins”. 《Oncogene》 10 (8): 1475–83. Apr 1995. PMID 7537362.  “Shb is a ubiquitously expressed Src homology 2 protein”. 《Oncogene》 9 (1): 19–27. Jan 1994. PMID 8302579.  “Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain protein Shb”. 《Oncogene》 13 (5): 955–61. Sep 1996. PMID 8806685.  “Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins”. 《Oncogene》 16 (7): 891–901. Feb 1998. doi:10.1038/sj.onc.1201607. PMID 9484780.  “The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells”. 《Cell Growth & Differentiation》 9 (9): 757–66. Sep 1998. PMID 9751119.  “Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells”. 《The Journal of Biological Chemistry》 274 (39): 28050–7. Sep 1999. doi:10.1074/jbc.274.39.28050. PMID 10488157.  “Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis”. 《Blood》 95 (11): 3403–11. Jun 2000. PMID 10828022.  “Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization”. 《Experimental Cell Research》 257 (2): 245–54. Jun 2000. doi:10.1006/excr.2000.4896. PMID 10837138.  “NGF-Dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway”. 《Experimental Cell Research》 259 (2): 370–7. Sep 2000. doi:10.1006/excr.2000.4984. PMID 10964504.  “SH2-Bbeta is a Rac-binding protein that regulates cell motility”. 《The Journal of Biological Chemistry》 277 (12): 10669–77. Mar 2002. doi:10.1074/jbc.M111138200. PMID 11786545.  “Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells”. 《European Journal of Biochemistry / FEBS》 269 (13): 3279–88. Jul 2002. doi:10.1046/j.1432-1033.2002.03008.x. PMID 12084069.  “The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells”. 《Molecular Biology of the Cell》 13 (8): 2881–93. Aug 2002. doi:10.1091/mbc.E02-02-0103. PMC 117949. PMID 12181353.  “IL-2 receptor signaling through the Shb adapter protein in T and NK cells”. 《Biochemical and Biophysical Research Communications》 296 (4): 929–36. Aug 2002. doi:10.1016/S0006-291X(02)02016-8. PMID 12200137.  “The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells”. 《Cellular Signalling》 15 (2): 171–9. Feb 2003. doi:10.1016/S0898-6568(02)00076-1. PMID 12464388.  “Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins”. 《Molecular Medicine》 8 (11): 695–704. Nov 2002. doi:10.1007/BF03402033. PMC 2039954. PMID 12520086.  “The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration”. 《The Journal of Biological Chemistry》 279 (21): 22267–75. May 2004. doi:10.1074/jbc.M312729200. PMID 15026417.