ZEB2

아연집게 E-box-결합 호메오박스2 (Zinc finger E-box-binding homeobox 2)는 단백질로 사람에서 ZEB2유전자가 암호화 하고 있다. SMADIP1유전자는 delta-EF1(TCF8)/Zfh1과의 하나로, 팔이 두 개인 아연집게/호메오도메인 단백질이다. SMADIP1은 수용체매개, 수용체활성 SMAD단백질과 함께 상호작용한다. ZEB2유전자의 변형은 Mowat-Wilson syndrome에 연관되어있다. GRCh38: Ensembl release 89: ENSG00000169554 - 앙상블, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000026872 - 앙상블, May 2017 “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.  “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.  “Entrez Gene: ZEB2 zinc finger E-box binding homeobox 2”.  Mowat DR; Wilson MJ; Goossens M (2003). “Mowat-Wilson syndrome”. 《J. Med. Genet.》 40 (5): 305–10. doi:10.1136/jmg.40.5.305. PMC 1735450. PMID 12746390.  Nagase T; Ishikawa K; Miyajima N; 외. (1998). “Prediction of the coding sequences of unidentified human genes. IX. 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Cell》 7 (6): 1267–78. doi:10.1016/S1097-2765(01)00260-X. PMID 11430829.  Cacheux V; Dastot-Le Moal F; Kääriäinen H; 외. (2001). “Loss-of-function mutations in SIP1 Smad interacting protein 1 result in a syndromic Hirschsprung disease”. 《Hum. Mol. Genet.》 10 (14): 1503–10. doi:10.1093/hmg/10.14.1503. PMID 11448942.  Tylzanowski P; Verschueren K; Huylebroeck D; Luyten FP (2001). “Smad-interacting protein 1 is a repressor of liver/bone/kidney alkaline phosphatase transcription in bone morphogenetic protein-induced osteogenic differentiation of C2C12 cells”. 《J. Biol. Chem.》 276 (43): 40001–7. doi:10.1074/jbc.M104112200. PMID 11477103.  Yamada K; Yamada Y; Nomura N; 외. (2002). “Nonsense and Frameshift Mutations in ZFHX1B, Encoding Smad-Interacting Protein 1, Cause a Complex Developmental Disorder with a Great Variety of Clinical Features”. 《Am. J. Hum. Genet.》 69 (6): 1178–85. doi:10.1086/324343. PMC 1235530. PMID 11592033.  Amiel J; Espinosa-Parrilla Y; Steffann J; 외. (2002). “Large-Scale Deletions and SMADIP1 Truncating Mutations in Syndromic Hirschsprung Disease with Involvement of Midline Structures”. 《Am. J. Hum. Genet.》 69 (6): 1370–7. doi:10.1086/324342. PMC 1235547. PMID 11595972.  Zweier C; Albrecht B; Mitulla B; 외. (2002). “"Mowat-Wilson" syndrome with and without Hirschsprung disease is a distinct, recognizable multiple congenital anomalies-mental retardation syndrome caused by mutations in the zinc finger homeo box 1B gene”. 《Am. J. Med. Genet.》 108 (3): 177–81. doi:10.1002/ajmg.10226. PMID 11891681.  Nagaya M; Kato J; Niimi N; 외. (2002). “Clinical features of a form of Hirschsprung's disease caused by a novel genetic abnormality”. 《J. Pediatr. Surg.》 37 (8): 1117–22. doi:10.1053/jpsu.2002.34455. PMID 12149685.  Guaita S; Puig I; Franci C; 외. (2002). “Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression”. 《J. Biol. Chem.》 277 (42): 39209–16. doi:10.1074/jbc.M206400200. PMID 12161443.  Espinosa-Parrilla Y; Amiel J; Augé J; 외. (2003). “Expression of the SMADIP1 gene during early human development”. 《Mech. Dev.》 114 (1–2): 187–91. doi:10.1016/S0925-4773(02)00062-X. PMID 12175509.  Yoneda M; Fujita T; Yamada Y; 외. (2002). “Late infantile Hirschsprung disease-mental retardation syndrome with a 3-bp deletion in ZFHX1B”. 《Neurology》 59 (10): 1637–40. PMID 12451214.  Strausberg RL; Feingold EA; Grouse LH; 외. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. 《Proc. Natl. Acad. Sci. U.S.A.》 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.  Postigo AA (2003). “Opposing functions of ZEB proteins in the regulation of the TGFβ/BMP signaling pathway”. 《EMBO J.》 22 (10): 2443–52. doi:10.1093/emboj/cdg225. PMC 155983. PMID 12743038.  Postigo AA; Depp JL; Taylor JJ; Kroll KL (2003). “Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins”. 《EMBO J.》 22 (10): 2453–62. doi:10.1093/emboj/cdg226. PMC 155984. PMID 12743039.  Zweier C; Temple IK; Beemer F; 외. (2003). “Characterisation of deletions of the ZFHX1B region and genotype-phenotype analysis in Mowat-Wilson syndrome”. 《J. Med. Genet.》 40 (8): 601–5. doi:10.1136/jmg.40.8.601. PMC 1735564. PMID 12920073.  GeneReviews/NIH/NCBI/UW entry on Mowat-Wilson syndrome 의학주제표목 (MeSH)의 ZEB2+protein,+human