SNAI1

아연집게 단백질 SNAI1 (Zinc finger protein SNAI1)은 단백질로 SNAI1유전자에 의해 암호화되어있다. 초파리 배아 단백질 SNAI1은 아연집게 전사 억제자로 중배엽내의 외배엽유전자의 발현을 하향 조절한다. 이 유전자에 의해 암호화 된 핵단백질은 구조적으로 초파리의 SNAI1 단백질과 유사하다. 그리고 발생하는 배아에 있어 중배엽의 형성에 매우 중요하다 생각된다. 2번 염색체의 최소한 두 가지의 변형된 위유전자가 발견되었다. SNAI1 유전자는 E-캐드헤린의 CDH1유전자의 발현을 하향 조절하여 EMT(epithelial-mesenchymal transition)을 유발하여 유방암의 재발하게 함을 보여주었다. SNAI1은 CTDSPL과 CTDSP1과 CTDSP2과 함께 단백질 상호작용을 보여준다. 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