사이토글로빈

사이토글로빈(영어: cytoglobin)은 사람과 포유류의 유전자인 CYGB의 단백질 산물이다. 사이토글로빈은 모든 조직에서 발현되며, 특히 해양 포유류에서 가장 많이 활용되는 글로빈 분자이다. 사이토글로빈은 2001년에 발견되었으며, 2002년에 사이토글로빈으로 명명되었다. 사이토글로빈은 저산소증으로부터 보호하는 역할을 하는 것으로 생각된다. 사이토글로빈의 예상되는 기능은 동맥혈에서 뇌로 산소를 전달하는 것이다. 사이토글로빈은 조직을 통한 산소의 확산을 촉진하고 산화 질소 또는 활성 산소를 제거하거나 산화 스트레스 동안 보호 기능을 제공할 수 있는 어디에서나 발현되는 6배위 헤모글로빈이다. CYGB 발현은 손상된 사람의 간의 간 성상세포와 간문맥 근섬유아세포를 구별할 수 있는 특정 마커로 사용될 수 있다. 글로빈 헤모글로빈 미오글로빈 뉴로글로빈 피토글로빈 레그헤모글로빈 GRCh38: Ensembl release 89: ENSG00000161544 - 앙상블, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000020810 - 앙상블, May 2017 “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.  “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.  “Entrez Gene: CYGB cytoglobin”.  Kawada N, Kristensen DB, Asahina K, Nakatani K, Minamiyama Y, Seki S, Yoshizato K (Jul 2001). “Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells”. 《The Journal of Biological Chemistry》 276 (27): 25318–23. doi:10.1074/jbc.M102630200. 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