BHLHB2

클래스 E 기본 나선-루프-나선 단백질 40(BHLHB2)은 인간에서 BHLHE40 유전자에 의해 암호화 된 단백질이다. DEC1은 다양한 조직에서 발현된 기본 나선-루프-나선 단백질을 암호화한다. 연골 세포에서의 발현은 Bt2cAMP의 첨가에 반응한다. 분화된 배아 연골 세포 발현 유전자 1은 세포 분화의 조절에 관여하는 것으로 여겨진다. GRCh38: Ensembl release 89: ENSG00000134107 - 앙상블, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000030103 - 앙상블, May 2017 “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.  “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.  “Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes”. 《Biochemical and Biophysical Research Communications》 236 (2): 294–8. Jul 1997. doi:10.1006/bbrc.1997.6960. PMID 9240428.  “Assignment1 of the human Stra13 gene (STRA13) to chromosome 3p26 by in situ hybridization”. 《Cytogenetics and Cell Genetics》 85 (3–4): 254–5. Oct 1999. doi:10.1159/000015305. PMID 10449910.  “Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation”. 《Differentiation; Research in Biological Diversity》 76 (9): 1006–22. Nov 2008. doi:10.1111/j.1432-0436.2008.00285.x. PMC 5728086. PMID 18557763.  “Entrez Gene: BHLHB2 basic helix-loop-helix domain containing, class B, 2”.  “Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2”. 《Journal of Biochemistry》 129 (3): 391–6. Mar 2001. doi:10.1093/oxfordjournals.jbchem.a002869. PMID 11226878.  “Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway”. 《The Journal of Biological Chemistry》 276 (18): 15306–15. May 2001. doi:10.1074/jbc.M010516200. PMID 11278694.  “Defective T cell activation and autoimmune disorder in Stra13-deficient mice”. 《Nature Immunology》 2 (11): 1040–7. Nov 2001. doi:10.1038/ni721. PMID 11668339.  “Identification of genes differentially induced by hypoxia in pancreatic cancer cells”. 《Biochemical and Biophysical Research Communications》 288 (4): 882–6. Nov 2001. doi:10.1006/bbrc.2001.5867. PMID 11688991.  “Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation”. 《The Biochemical Journal》 367 (Pt 2): 413–22. Oct 2002. doi:10.1042/BJ20020514. PMC 1222902. PMID 12119049.  “Stra13 homodimers repress transcription through class B E-box elements”. 《The Journal of Biological Chemistry》 277 (48): 46544–51. Nov 2002. doi:10.1074/jbc.M111652200. PMID 12297495.  “Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes”. 《The Journal of Biological Chemistry》 277 (49): 47014–21. Dec 2002. doi:10.1074/jbc.M204938200. PMID 12354771.  “Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages”. 《The Journal of Biological Chemistry》 277 (51): 50112–20. Dec 2002. doi:10.1074/jbc.M206771200. PMID 12384505.  “Dec1 and Dec2 are regulators of the mammalian molecular clock”. 《Nature》 419 (6909): 841–4. Oct 2002. doi:10.1038/nature01123. PMID 12397359.  “DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter”. 《The Journal of Biological Chemistry》 278 (19): 16899–907. May 2003. doi:10.1074/jbc.M300596200. PMID 12624110.  “DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer”. 《The Journal of Pathology》 200 (2): 222–8. Jun 2003. doi:10.1002/path.1330. PMID 12754744.  “STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets”. 《Journal of Molecular Biology》 340 (4): 641–53. Jul 2004. doi:10.1016/j.jmb.2004.05.025. PMID 15223310.  “Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1”. 《European Journal of Biochemistry / FEBS》 271 (22): 4409–19. Nov 2004. doi:10.1111/j.1432-1033.2004.04379.x. PMID 15560782.  “Association, mutual stabilization, and transcriptional activity of the STRA13 and MSP58 proteins”. 《Cellular and Molecular Life Sciences》 62 (4): 471–84. Feb 2005. doi:10.1007/s00018-004-4423-2. PMID 15719173.  “STRA13 expression and subcellular localisation in normal and tumour tissues: implications for use as a diagnostic and differentiation marker”. 《Journal of Medical Genetics》 42 (7): 565–76. Jul 2005. doi:10.1136/jmg.2004.029835. PMC 1736099. PMID 15994878.  “A human protein-protein interaction network: a resource for annotating the proteome”. 《Cell》 122 (6): 957–68. Sep 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070.