이노신 일인산 생성효소

이기능성 퓨린 생합성 단백질(영어: bifunctional purine biosynthesis protein), PURH는 사람에서 ATIC 유전자에 의해 암호화되는 단백질이다. ATIC는 5-아미노이미다졸-4-카복사마이드 리보뉴클레오타이드(AICAR)로부터 이노신 일인산(IMP)를 생성하는 효소를 암호화한다. 이 효소는 다음과 같이 2가지 기능을 가지고 있다. EC 2.1.2.3: 5-아미노이미다졸-4-카복사마이드 리보뉴클레오타이드 폼일기전이효소 EC 3.5.4.10: IMP 사이클로가수분해효소 이노신 일인산 (IMP) GRCh38: Ensembl release 89: ENSG00000138363 - 앙상블, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000026192 - 앙상블, May 2017 “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.  “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.  Rayl EA, Moroson BA, Beardsley GP (Mar 1996). “The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping”. 《J Biol Chem》 271 (4): 2225–33. doi:10.1074/jbc.271.4.2225. PMID 8567683.  Sugita T, Aya H, Ueno M, Ishizuka T, Kawashima K (Nov 1997). “Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase”. 《J Biochem》 122 (2): 309–13. doi:10.1093/oxfordjournals.jbchem.a021754. PMID 9378707.  “Entrez Gene: ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase”.  Rasmussen HH; van Damme J; Puype M; 외. (1993). “Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes”. 《Electrophoresis》 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667. S2CID 41855774.  지원되지 않는 변수 무시됨: |name-list-style= (도움말) Yamauchi M; Seki N; Mita K; 외. (1996). “Isolation of human purH gene expressed in the rodent transformant cells by subtractive enrichment of 3'-untranslated region of human transcript”. 《DNA Res.》 2 (6): 269–75. doi:10.1093/dnares/2.6.269. PMID 8867801.  지원되지 않는 변수 무시됨: |name-list-style= (도움말) Beardsley GP; Rayl EA; Gunn K; 외. (1998). 〈Structure and Functional Relationships in Human pur H〉. 《Purine and Pyrimidine Metabolism in Man IX》. Advances in Experimental Medicine and Biology 431. 221–6쪽. doi:10.1007/978-1-4615-5381-6_43. ISBN 978-0-306-45778-4. PMID 9598063.  지원되지 않는 변수 무시됨: |name-list-style= (도움말) Vergis JM, Bulock KG, Fleming KG, Beardsley GP (2001). “Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity”. 《J. Biol. Chem.》 276 (11): 7727–33. doi:10.1074/jbc.M009940200. PMID 11096114.  Bulock KG, Beardsley GP, Anderson KS (2002). “The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling”. 《J. Biol. Chem.》 277 (25): 22168–74. doi:10.1074/jbc.M111964200. PMID 11948179.  Strausberg RL; Feingold EA; Grouse LH; 외. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. 《Proc. Natl. Acad. Sci. U.S.A.》 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.  지원되지 않는 변수 무시됨: |name-list-style= (도움말) Cheong CG; Wolan DW; Greasley SE; 외. (2004). “Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates”. 《J. Biol. Chem.》 279 (17): 18034–45. doi:10.1074/jbc.M313691200. PMID 14966129.  지원되지 않는 변수 무시됨: |name-list-style= (도움말) Marie S; Heron B; Bitoun P; 외. (2004). “AICA-Ribosiduria: A Novel, Neurologically Devastating Inborn Error of Purine Biosynthesis Caused by Mutation of ATIC”. 《Am. J. Hum. Genet.》 74 (6): 1276–81. doi:10.1086/421475. PMC 1182092. PMID 15114530.  지원되지 않는 변수 무시됨: |name-list-style= (도움말) Dervieux T; Furst D; Lein DO; 외. (2004). “Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis”. 《Arthritis Rheum.》 50 (9): 2766–74. doi:10.1002/art.20460. PMID 15457444.  지원되지 않는 변수 무시됨: |name-list-style= (도움말) Gerhard DS; Wagner L; Feingold EA; 외. (2004). “The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. 《Genome Res.》 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.  지원되지 않는 변수 무시됨: |name-list-style= (도움말) Ewing RM; Chu P; Elisma F; 외. (2007). “Large-scale mapping of human protein–protein interactions by mass spectrometry”. 《Mol. Syst. Biol.》 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.  지원되지 않는 변수 무시됨: |name-list-style= (도움말) 의학주제표목 (MeSH)의 Inosine+monophosphate+synthase 모든 구조 정보의 개요는 유니프롯의 PDB로 볼 수 있습니다: P31939 (Human Bifunctional purine biosynthesis protein PURH (Inosine monophosphate synthase)) - PDBe-KB.