찰스 리 (생물학자)

찰스 리(Charles Lee)는 잭슨랩 유전체의학 연구소의 소장이며, 최신 유전체 기술 플랫폼을 이용하여 인간 유전체 변이를 연구하는 임상 세포유전학자이다. 그의 실험실은 세계 최초로 인간에서 유전체 단위 반복 변이가 존재함을 보고하였고, 이를 바탕으로 두개의 인간 유전체 CNV 지도를 개발하여 (Nature 444:444,2006; Nature 464:704,2010), 현재 병원과 연구실에서 활발히 사용하고 있는 마이크로어레이 염색체분석법(array-CGH, Array Comparative Genomic Hybridisation)의 바탕을 마련하였다. 또한, 그의 실험실은 인간 유전체 변이 연구뿐만 아니라, 제브라피쉬와 영장류를 포함한 다양한 개체에서 유전체 단위 반복 변이(CNV)의 발현과 차이에 대한 연구를 진행하고 있다. 1991 : BS in Genetics, University of Alberta 1993 : MS in Experimental Pathology, University of Alberta 1996 : Ph.D. in Medical Sciences, University of Alberta Positions held 2001-2003 : Instructor, Pathology, Harvard Medical School 2003-2008 : Assistant Professor, Pathology, Harvard Medical School 2008-2013 : Associate Professor, Pathology, Harvard Medical School 2013 : Director & Professor, Jackson Laboratory for Genomic Medicine 2004 : Iafrate AJ, Feuk L, Rivera MN, Listewnik ML, Donahoe PK, Qi Y, Scherer SW, Lee C. Detection of large-scale variation in the human genome. Nat Genet. 2004;36: 949-51 2006 : RedonR, IshikawaS, Fitch KR, FeukL, PerryG, Andrews TD, FieglerH, ShaperoMH, CarsonAR, ChenW, ChoEK, DallaireS, FreemanJ, GonzalezJR, GratacosM, HuangJ, KalaitzopoulosD, KomuraD, MacDonaldJ, MarshallC, MeiR, MontgomeryL, NishimuraK, OkamuraK, ShenF, TchindaJ, ValsesiaA, YangF, ZhangJJ, ZerjalT, ZhangJ, ArmengolL, ConradD, EstivillX, Tyler-Smith C*, CarterNP*, AburataniH*, JonesKW*, SchererSW*, HurlesME*, Lee C*. Global variation in copy number in the human genome. Nature. 2006;444: 444-54 2007 : Perry GH, Dominy NJ, Claw KG, Lee AS, Fiegler H, Redon R, Werner J, Villanea FA, Mountain JL, Misra R, Carter NP, Stone AC*, Lee C*. Diet and the evolution of human gene copy number variation. Nat Genet. 2007;39: 1256-60 2010 : Conrad D, Pinto D, Redon R, Feuk L, Gokcumen O, Zhang Y, Aerts J, Andrews TD, Barnes C, Campbell P, Fitzgerald T, Hu M, Ihm CH, Kristiansson K, MacArthur DG, MacDonald JR, Onyiah I, Pang AW, Robson S, Stirrups K, Valsesia A, Walter K, Wei J, Wellcome Trust Case Control Consortium, Tyler-Smith C*, Carter NP*, Scherer SW*, Hurles ME*, Lee C*. Common copy number variation in the human genome: mechanism, selection and disease association. Nature. 2010;464: 704-12 2011 : Mills RE, Walter K, Stewart C, Handsaker RE, Chen K, Alkan C, Abyzov A, Yoon SC, Ye K, Cheetham RK, Chinwalla A, Conrad DF, Fu Y, Grubert F, Hajirasouliha I, Hormozdiari F, Iakoucheva LM, Iqbal Z, Kang S, Kidd JM, Konkel MK, Korn J, Khurana E, Kural D, Lam HY, Leng J, Li R, Li Y, Lin CY, Luo R, Mu XJ, Nemesh J, Peckham HE, Rausch T, Scally A, Shi X, Stromberg MP, Stütz AM, Urban AE, Walker JA, Wu J, Zhang Y, Zhang ZD, Batzer MA, Ding L, Marth GT, McVean G, Sebat J, Snyder M, Wang J, Ye K, Eichler EE*, Gerstein MB*, Hurles ME*, McCarroll SA*, Korbel JO*, Lee C*.Mapping copy number variation by population-scale genome sequencing. Nature. 2011;470: 59-65 2013 : Gokcumen O, Tischler V, Tica J, Zhu Q, Iskow RC, Lee E, Fritz MH, Langdon A, Stutz AM, Pavlidis P, Benes V, Mills RE, Park PJ, Lee C*, Korbel JO*. Primate genome architecture influences structural variation mechanisms and functional consequences. ProcNatlAcadSci USA 2013; 110: 15764-9 2008 : 호암상 의학상 수상 2010 : George W. BrumleyJr, MD Memorial Award상 수상 2012 : Chen Global Investigator Award상 수상 2012 : Fellow, American Association for the Advancement of Science상 수상 copy number variants(CNVs) Nat Genet 36: 949, 2004 Lee, Charles; Listewnik ML (2004). “Detection of large-scale variation in the human genome”. 《Nat Genet.》 (36): 949–951.  Lee, Charles; Andrews TD (2006). “Global variation in copy number in the human genome”. 《Nature》 (444): 444–454.  Lee, Charles; Perry GH (2007). “Diet and the evolution of human gene copy number variation”. 《Nat Genet.》 (39): 1256–1260.  Lee, Charles; Conrad D (2010). “Common copy number variation in the human genome: mechanism, selection and disease association”. 《Nature》 (464): 704–712.  Lee, Charles; Mills RE (2011). “Mapping copy number variation by population-scale genome sequencing”. 《Nature》 (470): 59–65.  Lee, Charles; Gokcumen O (2013). “Primate genome architecture influences structural variation mechanisms and functional consequences”. 《ProcNatlAcadSci》 (110): 15764–15769.