プロテアーゼ活性化受容体4

プロテアーゼ活性化受容体4（プロテアーゼかっせいかじゅようたい4、英: protease-activated receptor 4、略称: PAR4）は、ヒトではF2RL3遺伝子にコードされるタンパク質である。F2RL3（coagulation factor II receptor-like 3）、thrombin receptor-like 3という名称でも知られる。 PAR4はGタンパク質と共役した7回膜貫通受容体ファミリーに属する。また、プロテアーゼ活性化受容体ファミリーのメンバーでもある。細胞外のN末端領域のタンパク質分解切断によって活性化され、切断によって新たに形成されたN末端がテザードリガンドとして機能して受容体を活性化する。 ^ a b c GRCh38: Ensembl release 89: ENSG00000127533 - Ensembl, May 2017 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050147 - Ensembl, May 2017 ^ Human PubMed Reference: ^ Mouse PubMed Reference: ^ a b “Entrez Gene: F2RL3 coagulation factor II (thrombin) receptor-like 3”. 2021年9月5日閲覧。 “Protease-activated receptors in cardiovascular diseases.”. Circulation 114 (10): 1070–7. (2006). doi:10.1161/CIRCULATIONAHA.105.574830. PMID 16952995.  “Cloning and characterization of human protease-activated receptor 4.”. Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6642–6. (1998). Bibcode: 1998PNAS...95.6642X. doi:10.1073/pnas.95.12.6642. PMC 22580. PMID 9618465. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC22580/.  “A dual thrombin receptor system for platelet activation.”. Nature 394 (6694): 690–4. (1998). Bibcode: 1998Natur.394..690K. doi:10.1038/29325. PMID 9716134.  “Gene and locus structure and chromosomal localization of the protease-activated receptor gene family.”. J. Biol. Chem. 273 (36): 23290–6. (1998). doi:10.1074/jbc.273.36.23290. PMID 9722561.  “Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.”. J. Clin. Invest. 103 (6): 879–87. (1999). doi:10.1172/JCI6042. PMC 408153. PMID 10079109. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC408153/.  “Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity.”. Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11189–93. (1999). Bibcode: 1999PNAS...9611189A. doi:10.1073/pnas.96.20.11189. PMC 18009. PMID 10500152. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC18009/.  “Cathepsin G activates protease-activated receptor-4 in human platelets.”. J. Biol. Chem. 275 (10): 6819–23. (2000). doi:10.1074/jbc.275.10.6819. PMID 10702240.  “PAR3 is a cofactor for PAR4 activation by thrombin.”. Nature 404 (6778): 609–13. (2000). Bibcode: 2000Natur.404..609N. doi:10.1038/35007085. PMID 10766244.  “Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2.”. J. Immunol. 167 (11): 6615–22. (2002). doi:10.4049/jimmunol.167.11.6615. PMID 11714832.  “Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells.”. J. Immunol. 168 (7): 3577–85. (2002). doi:10.4049/jimmunol.168.7.3577. PMID 11907122.  “PAR-4 agonist AYPGKF stimulates thromboxane production by human platelets.”. Arterioscler. Thromb. Vasc. Biol. 22 (5): 861–6. (2002). doi:10.1161/01.ATV.0000014742.56572.25. PMID 12006403.  “Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak syndrome.”. Thromb. Haemost. 87 (4): 722–7. (2003). doi:10.1055/s-0037-1613071. PMID 12008957.  “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. (2003). doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.  Owen WG (2003). “PAR-3 is a low-affinity substrate, high affinity effector of thrombin.”. Biochem. Biophys. Res. Commun. 305 (1): 166–8. doi:10.1016/S0006-291X(03)00732-0. PMID 12732212.  “Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP.”. J. Thromb. Haemost. 1 (4): 798–804. (2003). doi:10.1046/j.1538-7836.2003.00138.x. PMID 12871418.  “The role of PAR4 in thrombin-induced thromboxane production in human platelets.”. Thromb. Haemost. 90 (2): 299–308. (2004). doi:10.1160/TH03-02-0103. PMID 12888878.  “ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.”. Mol. Cell. Biol. 23 (17): 6174–86. (2003). doi:10.1128/MCB.23.17.6174-6186.2003. PMC 180930. PMID 12917339. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC180930/.  “Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage.”. Biochem. J. 376 (Pt 3): 733–40. (2004). doi:10.1042/BJ20030954. PMC 1223816. PMID 13678420. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223816/.  “Redistribution of glycoprotein Ib within platelets in response to protease-activated receptors 1 and 4: roles of cytoskeleton and calcium.”. J. Thromb. Haemost. 1 (10): 2206–15. (2004). doi:10.1046/j.1538-7836.2003.00436.x. PMID 14521606.  プロテアーゼ活性化受容体 表示 編集