チモポイエチン

チモポイエチン（Thymopoietin、Lamina-associated polypeptide 2 (LAP2), isoforms beta/gamma）はタンパク質の一つ。ヒトではTMPO 遺伝子にコードされる。LAP2は、核内膜タンパク質（英語版）である。 胸腺でのCD90（英語版）の誘導に関与するタンパク質である。TMPO遺伝子はすべての細胞で発現しており、選択的スプライシングにより75kDa（α）、51kDa（β）、39kDa（γ）のタンパク質をコードする。ヒトTMPO 遺伝子は染色体バンド12q22に位置し、8つのエクソンから構成される。TMPOαは細胞核に散在し、TMPOβとγは核膜に局在する。TMPOβはマウスタンパク質LAP2のヒトホモログである。LAP2は有糸分裂期にラミンB1（英語版）のリン酸化を制御することによってラミンB1と染色体を結合させ、核構造を制御している。 チモポイエチンは、自己統合障壁因子1（英語版）（BAF1）、AKAP8L（英語版）、LMNB1（英語版）、LMNAと相互作用する事が示されている。 ^ a b c GRCh38: Ensembl release 89: ENSG00000120802 - Ensembl, May 2017 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019961 - Ensembl, May 2017 ^ Human PubMed Reference: ^ Mouse PubMed Reference: ^ G, Goldstein、T, Audhya、A, Heavner G.「チモポイエチン 免疫制御性ポリペプチドの構造的研究」『Peptides』1981年、535–539頁。  ^ “Weblio和英辞書 -「チモポイエチン」の英語・英語例文・英語表現”. ejje.weblio.jp. 2021年9月27日閲覧。 ^ “Three distinct human thymopoietins are derived from alternatively spliced mRNAs”. Proceedings of the National Academy of Sciences of the United States of America 91 (14): 6283–7. (Jul 1994). Bibcode: 1994PNAS...91.6283H. doi:10.1073/pnas.91.14.6283. PMC 44185. PMID 7517549. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC44185/.  ^ “Entrez Gene: TMPO thymopoietin”. 2021年9月27日閲覧。 ^ “Inner nuclear membrane proteins: functions and targeting”. Cellular and Molecular Life Sciences 58 (12–13): 1741–7. (Nov 2001). doi:10.1007/PL00000813. PMID 11766875.  ^ “Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2”. Genomics 28 (2): 198–205. (Jul 1995). doi:10.1006/geno.1995.1131. PMID 8530026.  ^ “LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction”. Journal of Cell Science 112 ( Pt 15) (15): 2485–92. (Aug 1999). doi:10.1242/jcs.112.15.2485. PMID 10393804.  ^ “HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics”. Journal of Cell Science 113 Pt 21 (21): 3703–13. (Nov 2000). doi:10.1242/jcs.113.21.3703. PMID 11034899.  ^ “HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication”. The Journal of Cell Biology 160 (2): 177–88. (Jan 2003). doi:10.1083/jcb.200210026. PMC 2172640. PMID 12538639. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172640/.  ^ “Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin”. European Journal of Biochemistry / FEBS 251 (3): 729–33. (Feb 1998). doi:10.1046/j.1432-1327.1998.2510729.x. PMID 9490046.  ^ “Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation”. Cell 73 (7): 1267–79. (Jul 1993). doi:10.1016/0092-8674(93)90355-T. PMID 8324822.  ^ “Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma protein”. Molecular Biology of the Cell 13 (12): 4401–13. (Dec 2002). doi:10.1091/mbc.E02-07-0450. PMC 138642. PMID 12475961. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138642/.  ^ “Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins”. Journal of Cell Science 113 Pt 19 (19): 3473–84. (Oct 2000). doi:10.1242/jcs.113.19.3473. PMID 10984438.  “Review: lamina-associated polypeptide 2 isoforms and related proteins in cell cycle-dependent nuclear structure dynamics”. Journal of Structural Biology 129 (2–3): 335–45. (Apr 2000). doi:10.1006/jsbi.2000.4212. PMID 10806084.  “Bioassay determinations of thymopoietin and thymic hormone levels in human plasma”. Proceedings of the National Academy of Sciences of the United States of America 74 (6): 2541–5. (Jun 1977). Bibcode: 1977PNAS...74.2541T. doi:10.1073/pnas.74.6.2541. PMC 432209. PMID 302007. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC432209/.  “Peptide analogs of thymopentin distinguish distinct thymopoietin receptor specificities on two human T cell lines”. Regulatory Peptides 27 (2): 257–62. (Feb 1990). doi:10.1016/0167-0115(90)90044-W. PMID 2158125.  “Immunoassay for bovine serum thymopoietin: discrimination from splenin by monoclonal antibodies”. Archives of Biochemistry and Biophysics 228 (1): 292–8. (Jan 1984). doi:10.1016/0003-9861(84)90070-5. PMID 6364989.  “A new thymopoietin precursor gene from human thymus”. Biochemistry and Molecular Biology International 34 (5): 927–33. (Nov 1994). PMID 7703909.  “Isolation and complete amino acid sequence of human thymopoietin and splenin”. Proceedings of the National Academy of Sciences of the United States of America 91 (13): 6249. (Jun 1994). Bibcode: 1994PNAS...91.6249G. doi:10.1073/pnas.91.13.6249. PMC 44176. PMID 8016147. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC44176/.  “Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2”. Genomics 28 (2): 198–205. (Jul 1995). doi:10.1006/geno.1995.1131. PMID 8530026.  “A "double adaptor" method for improved shotgun library construction”. Analytical Biochemistry 236 (1): 107–13. (Apr 1996). doi:10.1006/abio.1996.0138. PMID 8619474.  “The characterization and localization of the mouse thymopoietin/lamina-associated polypeptide 2 gene and its alternatively spliced products”. Genome Research 6 (5): 361–70. (May 1996). doi:10.1101/gr.6.5.361. PMID 8743987.  “Large-scale concatenation cDNA sequencing”. Genome Research 7 (4): 353–8. (Apr 1997). doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139146/.  “The major nuclear envelope targeting domain of LAP2 coincides with its lamin binding region but is distinct from its chromatin interaction domain”. The Journal of Biological Chemistry 273 (7): 4213–9. (Feb 1998). doi:10.1074/jbc.273.7.4213. PMID 9461618.  “Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin”. European Journal of Biochemistry / FEBS 251 (3): 729–33. (Feb 1998). doi:10.1046/j.1432-1327.1998.2510729.x. PMID 9490046.  “Detergent-salt resistance of LAP2alpha in interphase nuclei and phosphorylation-dependent association with chromosomes early in nuclear assembly implies functions in nuclear structure dynamics”. The EMBO Journal 17 (16): 4887–902. (Aug 1998). doi:10.1093/emboj/17.16.4887. PMC 1170818. PMID 9707448. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170818/.  “LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction”. Journal of Cell Science 112 ( Pt 15) (15): 2485–92. (Aug 1999). doi:10.1242/jcs.112.15.2485. PMID 10393804.  “On the role of thymopoietins in cell proliferation. Immunochemical evidence for new members of the human thymopoietin family”. Biological Chemistry 380 (6): 653–60. (Jun 1999). doi:10.1515/BC.1999.081. PMID 10430029.  “Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins”. Journal of Cell Science 113 Pt 19 (19): 3473–84. (Oct 2000). doi:10.1242/jcs.113.19.3473. PMID 10984438.  “HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics”. Journal of Cell Science 113 Pt 21 (21): 3703–13. (Nov 2000). doi:10.1242/jcs.113.21.3703. PMID 11034899.  Thymopoietins - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス（英語）