プロテアーゼ活性化受容体3

プロテアーゼ活性化受容体3（プロテアーゼかっせいかじゅようたい3、英: protease-activated receptor 3、略称: PAR3）は、ヒトではF2RL2遺伝子にコードされるタンパク質である。F2RL2（coagulation factor II receptor-like 2）、thrombin receptor-like 2という名称でも知られる。 PAR3はGタンパク質と共役した7回膜貫通受容体ファミリーに属する。また、プロテアーゼ活性化受容体ファミリーのメンバーでもあり、トロンビンによって活性化される。PAR3は細胞外のN末端領域のタンパク質分解切断によって活性化され、新たに形成されたN末端がテザードリガンドとして受容体を活性化する。PAR3はトロンビンによるPAR4の切断と活性化のコファクターとしても機能する。 ^ a b c GRCh38: Ensembl release 89: ENSG00000164220 - Ensembl, May 2017 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021675 - Ensembl, May 2017 ^ Human PubMed Reference: ^ Mouse PubMed Reference: ^ “Entrez Gene: F2RL2 coagulation factor II (thrombin) receptor-like 2”. 2021年9月5日閲覧。 ^ Nakanishi-Matsui, M.; Zheng, Y. W.; Sulciner, D. J.; Weiss, E. J.; Ludeman, M. J.; Coughlin, S. R. (2000-04-06). “PAR3 is a cofactor for PAR4 activation by thrombin”. Nature 404 (6778): 609–613. doi:10.1038/35007085. ISSN 0028-0836. PMID 10766244. https://pubmed.ncbi.nlm.nih.gov/10766244.  “International Union of Pharmacology. XXVIII. Proteinase-activated receptors.”. Pharmacol. Rev. 54 (2): 203–17. (2002). doi:10.1124/pr.54.2.203. PMID 12037136.  “Protease-activated receptor 3 is a second thrombin receptor in humans.”. Nature 386 (6624): 502–6. (1997). Bibcode: 1997Natur.386..502I. doi:10.1038/386502a0. PMID 9087410.  “The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a Par gene cluster and characterization in vascular endothelial cells and platelets.”. J. Biol. Chem. 273 (24): 15061–8. (1998). doi:10.1074/jbc.273.24.15061. PMID 9614115.  “Cloning and characterization of human protease-activated receptor 4”. Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6642–6. (1998). Bibcode: 1998PNAS...95.6642X. doi:10.1073/pnas.95.12.6642. PMC 22580. PMID 9618465. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC22580/.  “Protease-activated receptor genes are clustered on 5q13”. Blood 92 (1): 25–31. (1998). doi:10.1182/blood.V92.1.25.413k41_25_31. PMID 9639495.  “A dual thrombin receptor system for platelet activation”. Nature 394 (6694): 690–4. (1998). Bibcode: 1998Natur.394..690K. doi:10.1038/29325. PMID 9716134.  “Gene and locus structure and chromosomal localization of the protease-activated receptor gene family”. J. Biol. Chem. 273 (36): 23290–6. (1998). doi:10.1074/jbc.273.36.23290. PMID 9722561.  “Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin”. J. Clin. Invest. 103 (6): 879–87. (1999). doi:10.1172/JCI6042. PMC 408153. PMID 10079109. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC408153/.  “alpha-Thrombin stimulates contraction of human bronchial rings by activation of protease-activated receptors”. Am. J. Physiol. 277 (1 Pt 1): L22–9. (1999). doi:10.1152/ajplung.1999.277.1.L22. PMID 10409227.  “PAR3 is a cofactor for PAR4 activation by thrombin”. Nature 404 (6778): 609–13. (2000). Bibcode: 2000Natur.404..609N. doi:10.1038/35007085. PMID 10766244.  “Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1”. J. Biol. Chem. 275 (18): 13502–9. (2000). doi:10.1074/jbc.275.18.13502. PMID 10788464.  “Neutrophil proteases can inactivate human PAR3 and abolish the co-receptor function of PAR3 on murine platelets”. Thromb. Haemost. 85 (3): 533–8. (2001). doi:10.1055/s-0037-1615617. PMID 11307827.  “Role of thrombin signalling in platelets in haemostasis and thrombosis”. Nature 413 (6851): 74–8. (2001). Bibcode: 2001Natur.413...74S. doi:10.1038/35092573. PMID 11544528.  “Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2”. J. Immunol. 167 (11): 6615–22. (2002). doi:10.4049/jimmunol.167.11.6615. PMID 11714832.  “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. (2003). doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.  “The pattern of expression of protease-activated receptors (PARs) during early trophoblast development”. J. Pathol. 200 (1): 47–52. (2003). doi:10.1002/path.1338. PMID 12692840.  Owen WG (2003). “PAR-3 is a low-affinity substrate, high affinity effector of thrombin”. Biochem. Biophys. Res. Commun. 305 (1): 166–8. doi:10.1016/S0006-291X(03)00732-0. PMID 12732212.  “Thrombin-induced Ca2+ mobilization in human gingival fibroblasts is mediated by protease-activated receptor-1 (PAR-1)”. Life Sci. 73 (3): 301–10. (2003). doi:10.1016/S0024-3205(03)00269-8. PMID 12757837.  プロテアーゼ活性化受容体 表示 編集