ジョージ・チャーチ (遺伝学者)

ジョージ・マクドナルド・チャーチ（George McDonald Church、1954年8月28日 - ）は、アメリカ合衆国の遺伝学者、分子工学者、化学者。 ハーバード大学医学部ロバート・ウィンスロップ遺伝学教授、マサチューセッツ工科大学教授、原子科学者会報理事。ヴィース研究所（Wyss Institute for Biologically Inspired Engineering）共同創立者。 2011年 - バウアー賞 2016年 - トムソン・ロイター引用栄誉賞 チャーチは、ゲノムのシークエンシングとそのデータの解釈、 合成生物学とゲノム工学、および脳活動のマッピングと「機能的コネクトーム 」の確立を提案する神経科学の新興領域における専門家の貢献で知られる。中でも、チャーチはパーソナル・ゲノミクスと合成生物学の専門分野を開拓したことで知られる。 彼はこれらの領域、およびエコロジカル製品および天然製品化学から燃料生産に至るまでの数々の事業を共同創設してきた。今まで起業してきたものにはKnome、LS9、およびJoule Unlimited（それぞれ、人間のゲノミクス、グリーンサスティナブルケミストリー、および太陽電池の事業）などがある。 2015年現在[update]、Google Scholarによれば、最も引用された研究は、PNAS、Nature Genetics 、 Nature Reviewsなどの査読付き科学学術誌に発表されている。他にはNature Review Genetics、Intelligent Systems for Molecular Biology（ISMB）、 Nature Biotechnology、サイエンス Journal of Molecular Biology、 <i>Pacific Symposium on Biocomputing（PSB）</i>、<i>Journal of Bacteriology</i> 、 Nature、 Nature Methods 、 Genome Biology、Bioinformatics、 PLOS Genetics、およびNucleic Acids Research 。 ^ a b “Church, George”. Biography Reference Bank. The H. W. Wilson Company (2010年). 10 December 2011閲覧。[リンク切れ] ^ Nair, P. (2012). “Profile of George M. Church”. Proceedings of the National Academy of Sciences 109 (30): 11893–11895. Bibcode: 2012PNAS..10911893N. doi:10.1073/pnas.1204148109. PMC 3409755. PMID 22474375. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409755/.  ^ Church, G.; Gilbert, W. (1984). “Genomic sequencing”. Proceedings of the National Academy of Sciences of the United States of America 81 (7): 1991–1995. Bibcode: 1984PNAS...81.1991C. doi:10.1073/pnas.81.7.1991. PMC 345422. PMID 6326095. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC345422/.  ^ Segrè, D.; Vitkup, D.; Church, G. M. (2002). “Analysis of optimality in natural and perturbed metabolic networks”. Proceedings of the National Academy of Sciences of the United States of America 99 (23): 15112–15117. Bibcode: 2002PNAS...9915112S. doi:10.1073/pnas.232349399. PMC 137552. PMID 12415116. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC137552/.  ^ Chae, H. Z.; Robison, K; Poole, L. B.; Church, G; Storz, G; Rhee, S. G. (1994). “Cloning and sequencing of thiol-specific antioxidant from mammalian brain: Alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes”. Proceedings of the National Academy of Sciences of the United States of America 91 (15): 7017–21. Bibcode: 1994PNAS...91.7017C. doi:10.1073/pnas.91.15.7017. PMC 44329. PMID 8041738. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC44329/.  ^ Kim, J.; Krichevsky, A.; Grad, Y.; Hayes, G.; Kosik, K.; Church, G.; Ruvkun, G. (2004). “Identification of many microRNAs that copurify with polyribosomes in mammalian neurons”. Proceedings of the National Academy of Sciences of the United States of America 101 (1): 360–365. Bibcode: 2003PNAS..101..360K. doi:10.1073/pnas.2333854100. PMC 314190. PMID 14691248. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC314190/.  ^ Tavazoie, S; Hughes, J. D.; Campbell, M. J.; Cho, R. J.; Church, G. M. (1999). “Systematic determination of genetic network architecture”. Nature Genetics 22 (3): 281–5. doi:10.1038/10343. PMID 10391217.  ^ Pilpel, Y; Sudarsanam, P; Church, G. M. (2001). “Identifying regulatory networks by combinatorial analysis of promoter elements”. Nature Genetics 29 (2): 153–9. doi:10.1038/ng724. PMID 11547334.  ^ Ge, H; Liu, Z; Church, G. M.; Vidal, M (2001). “Correlation between transcriptome and interactome mapping data from Saccharomyces cerevisiae”. Nature Genetics 29 (4): 482–6. doi:10.1038/ng776. PMID 11694880.  ^ Shendure, J; Mitra, R. D.; Varma, C; Church, G. M. (2004). “Advanced sequencing technologies: Methods and goals”. Nature Reviews Genetics 5 (5): 335–44. doi:10.1038/nrg1325. PMID 15143316.  ^ Cheng, Y; Church, G. M. (2000). “Biclustering of expression data”. Proceedings. International Conference on Intelligent Systems for Molecular Biology 8: 93–103. PMID 10977070.  ^ Tompa, M; Li, N; Bailey, T. L.; Church, G. M.; De Moor, B; Eskin, E; Favorov, A. V.; Frith, M. C. et al. (2005). “Assessing computational tools for the discovery of transcription factor binding sites”. Nature Biotechnology 23 (1): 137–44. doi:10.1038/nbt1053. PMID 15637633. https://lirias.kuleuven.be/handle/123456789/70322.  ^ Roth, F. P.; Hughes, J. D.; Estep, P. W.; Church, G. M. (1998). “Finding DNA regulatory motifs within unaligned noncoding sequences clustered by whole-genome mRNA quantitation”. Nature Biotechnology 16 (10): 939–45. doi:10.1038/nbt1098-939. PMID 9788350.  ^ Ball, M. P.; Li, J. B.; Gao, Y; Lee, J. H.; Leproust, E. M.; Park, I. H.; Xie, B; Daley, G. Q. et al. (2009). “Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells”. Nature Biotechnology 27 (4): 361–8. doi:10.1038/nbt.1533. PMC 3566772. PMID 19329998. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566772/.  ^ Selinger, D. W.; Cheung, K. J.; Mei, R; Johansson, E. M.; Richmond, C. S.; Blattner, F. R.; Lockhart, D. J.; Church, G. M. (2000). “RNA expression analysis using a 30 base pair resolution Escherichia coli genome array”. Nature Biotechnology 18 (12): 1262–8. doi:10.1038/82367. PMID 11101804.  ^ Mali, P.; Yang, L.; Esvelt, K. M.; Aach, J.; Guell, M.; Dicarlo, J. E.; Norville, J. E.; Church, G. M. (2013). “RNA-Guided Human Genome Engineering via Cas9”. Science 339 (6121): 823–826. Bibcode: 2013Sci...339..823M. doi:10.1126/science.1232033. PMC 3712628. PMID 23287722. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712628/.  ^ Shendure, J.; Porreca, J.; Reppas, B.; Lin, X.; McCutcheon, P.; Rosenbaum, M.; Wang, D.; Zhang, K. et al. (September 2005). “Accurate Multiplex Polony Sequencing of an Evolved Bacterial Genome”. Science 309 (5741): 1728–1732. Bibcode: 2005Sci...309.1728S. doi:10.1126/science.1117389. ISSN 0036-8075. PMID 16081699. https://semanticscholar.org/paper/8a21c5ea21a3b6b9ac217336e85796c4a9c8868b.  ^ Ephrussi, A; Church, G. M.; Tonegawa, S; Gilbert, W (1985). “B lineage--specific interactions of an immunoglobulin enhancer with cellular factors in vivo”. Science 227 (4683): 134–40. Bibcode: 1985Sci...227..134E. doi:10.1126/science.3917574. PMID 3917574.  ^ Drmanac, R; Sparks, A. B.; Callow, M. J.; Halpern, A. L.; Burns, N. L.; Kermani, B. G.; Carnevali, P; Nazarenko, I et al. (2010). “Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays”. Science 327 (5961): 78–81. Bibcode: 2010Sci...327...78D. doi:10.1126/science.1181498. PMID 19892942. https://semanticscholar.org/paper/6482f1219c91620677c79aca796cee2bba92781b.  ^ Sommer, M. O. A.; Dantas, G.; Church, G. M. (2009). “Functional Characterization of the Antibiotic Resistance Reservoir in the Human Microflora”. Science 325 (5944): 1128–1131. Bibcode: 2009Sci...325.1128S. doi:10.1126/science.1176950. PMC 4720503. PMID 19713526. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720503/.  ^ Friedland, A. E.; Lu, T. K.; Wang, X; Shi, D; Church, G; Collins, J. J. (2009). “Synthetic gene networks that count”. Science 324 (5931): 1199–202. Bibcode: 2009Sci...324.1199F. doi:10.1126/science.1172005. PMC 2690711. PMID 19478183. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690711/.  ^ Hughes, J. D.; Estep, P. W.; Tavazoie, S; Church, G. M. (2000). “Computational identification of cis-regulatory elements associated with groups of functionally related genes in Saccharomyces cerevisiae”. Journal of Molecular Biology 296 (5): 1205–14. doi:10.1006/jmbi.2000.3519. PMID 10698627. https://semanticscholar.org/paper/1c80335454d8db7c75212f5ac771f822e4d1c9c4.  ^ Sussman, J. L.; Holbrook, S. R.; Warrant, R. W.; Church, G. M.; Kim, S. H. (1978). “Crystal structure of yeast phenylalanine transfer RNA. I. Crystallographic refinement”. Journal of Molecular Biology 123 (4): 607–30. doi:10.1016/0022-2836(78)90209-7. PMID 357742.  ^ Robison, K; McGuire, A. M.; Church, G. M. (1998). “A comprehensive library of DNA-binding site matrices for 55 proteins applied to the complete Escherichia coli K-12 genome”. Journal of Molecular Biology 284 (2): 241–54. doi:10.1006/jmbi.1998.2160. PMID 9813115.  ^ Chen, T; He, H. L.; Church, G. M. (1999). “Modeling gene expression with differential equations”. Pacific Symposium on Biocomputing: 29–40. PMID 10380183.  ^ Link, A. J.; Phillips, D.; Church, G. M. (1997). “Methods for generating precise deletions and insertions in the genome of wild-type Escherichia coli: Application to open reading frame characterization”. Journal of Bacteriology 179 (20): 6228–6237. doi:10.1128/jb.179.20.6228-6237.1997. PMC 179534. PMID 9335267. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC179534/.  ^ Wang, H. H.; Isaacs, F. J.; Carr, P. A.; Sun, Z. Z.; Xu, G; Forest, C. R.; Church, G. M. (2009). “Programming cells by multiplex genome engineering and accelerated evolution”. Nature 460 (7257): 894–8. Bibcode: 2009Natur.460..894W. doi:10.1038/nature08187. PMC 4590770. PMID 19633652. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590770/.  ^ Porreca, G. J.; Zhang, K.; Li, J. B.; Xie, B.; Austin, D.; Vassallo, S. L.; Leproust, E. M.; Peck, B. J. et al. (2007). “Multiplex amplification of large sets of human exons”. Nature Methods 4 (11): 931–6. doi:10.1038/nmeth1110. PMID 17934468.  ^ Choe, S. E.; Boutros, M; Michelson, A. M.; Church, G. M.; Halfon, M. S. (2005). “Preferred analysis methods for Affymetrix Gene Chips revealed by a wholly defined control dataset”. Genome Biology 6 (2): R16. doi:10.1186/gb-2005-6-2-r16. PMC 551536. PMID 15693945. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC551536/.  ^ Aach, J; Church, G. M. (2001). “Aligning gene expression time series with time warping algorithms”. Bioinformatics 17 (6): 495–508. doi:10.1093/bioinformatics/17.6.495. PMID 11395426.  ^ Teichmann, S. A.; Chothia, C; Church, G. M.; Park, J (2000). “Fast assignment of protein structures to sequences using the intermediate sequence library PDB-ISL”. Bioinformatics 16 (2): 117–24. doi:10.1093/bioinformatics/16.2.117. PMID 10842732. http://arep.med.harvard.edu/pdf/Teichmann00.pdf.  ^ Kettler, G. C.; Martiny, A. C.; Huang, K; Zucker, J; Coleman, M. L.; Rodrigue, S; Chen, F; Lapidus, A et al. (2007). “Patterns and implications of gene gain and loss in the evolution of Prochlorococcus”. PLOS Genetics 3 (12): e231. doi:10.1371/journal.pgen.0030231. PMC 2151091. PMID 18159947. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151091/.  ^ Bulyk, M. L.; Johnson, P. L.; Church, G. M. (2002). “Nucleotides of transcription factor binding sites exert interdependent effects on the binding affinities of transcription factors”. Nucleic Acids Research 30 (5): 1255–61. doi:10.1093/nar/30.5.1255. PMC 101241. PMID 11861919. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC101241/.  遺伝暗号と脳暗号の未来 （2017年2月8日NIHでのチャーチ博士のセミナー） TEDMEDの スピーカープロフィール