RASGRP3

Rasグアニル放出タンパク質3（RAS guanyl-releasing protein 3、RasGRP3）は、ヒトのRASGRP3遺伝子にコードされているタンパク質である。 GTPアーゼのRASサブファミリーのメンバーは、シグナル伝達において不活性型であるGDP結合型と活性型のGTP結合型の間を循環するGTP/GDP-制御スイッチとして機能する。RASGRP3といったグアニンヌクレオチド交換因子 (GEF) は、GTP結合型を維持するためのGTPとの会合を促進することによってRAS活性化剤として働く。また、細胞膜受容体とRAS活性化の間の重要な役割を果たす。 RASGRP3はPRKCDと相互作用することが明らかにされている。 ^ a b c GRCh38: Ensembl release 89: ENSG00000152689 - Ensembl, May 2017 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071042 - Ensembl, May 2017 ^ Human PubMed Reference: ^ Mouse PubMed Reference: ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). “Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro”. DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. 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