核内受容体コアクチベーター5

核内受容体コアクチベーター5（NCOA5: nuclear receptor coactivator 5）あるいはCAI（coactivator independent of AF-2 function）は、ヒトのNCOA5遺伝子によってコードされているタンパク質である。 NCOA5は、エストロゲン受容体α及びβ並びにオーファン核内受容体Rev-ErbAβの共制御因子である。このタンパク質は細胞核に局在し、コアクチベーターとコリプレッサーの両方の機能を持つと考えられている。上記の受容体における、他の共受容体との相互作用を調節することが知られているAF2ドメインとは、NCOA5を含む核内受容体との相互作用とは関連しない。この遺伝子より産まれた、選択的スプライシングによる2つの転写変異体が発見されている。 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039804 - Ensembl, May 2017 ^ Human PubMed Reference: ^ Mouse PubMed Reference: ^ a b “Entrez Gene: NCOA5 nuclear receptor coactivator 5”. アメリカ国立生物工学情報センター. 2021年8月14日閲覧。 ^ Frédéric Sauvé, Linda D. B. McBroom, Josette Gallant, Anna N. Moraitis, Fernand Labrie, and Vincent Giguère (January 2001). “CIA, a Novel Estrogen Receptor Coactivator with a Bifunctional Nuclear Receptor Interacting Determinant”. Molecular and Cellular Biology 21 (1): 343–53. doi:10.1128/MCB.21.1.343-353.2001. PMC 88807. PMID 11113208. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC88807/.  Jesper V. 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