芳香族炭化水素受容体核内輸送体

芳香族炭化水素受容体核内輸送体（ARNT: aryl hydrocarbon receptor nuclear translocator）は、リガンド結合型芳香族炭化水素受容体（AhR）と複合体を形成するタンパク質であり、AhRが受容体として機能するために必要である。また、低酸素誘導因子1（HIF1）のベータサブユニットとしても知られている。TEL-ARNT融合タンパク質の発現をもたらす遺伝子座のt(1; 12)(q21; p13)転座は、急性骨髄芽球性白血病と関連している。この遺伝子について、異なるアイソフォームをコードする3つのスプライスバリアントが報告されている。 AhRは、生体異物代謝に関与するいくつかの酵素の誘導に関与している。リガンドを含まない、細胞質ゾル型のAhRは、熱ショックタンパク質90（Hsp90）と複合体を形成する。ダイオキシンと多環芳香族炭化水素を含むリガンドの結合は、リガンド結合サブユニットの核への転座をもたらす。生体異物代謝に関与する酵素の誘導は、これら酵素の遺伝子のプロモーター内の生体異物応答エレメントへのリガンド結合型AhRの結合を介して発生する。 ARNTは、以下の生体分子と相互作用する。 芳香族炭化水素受容体相互作用タンパク質（AIP） 芳香族炭化水素受容体（AHR） 内皮PASドメイン含有タンパク質（EPAS1） 低酸素誘導因子1A（HIF1A） 核内受容体コアクチベーター2（NCOA2） SIM1 SIM2 ^ a b c GRCh38: Ensembl release 89: ENSG00000143437 - Ensembl, May 2017 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015522 - Ensembl, May 2017 ^ Human PubMed Reference: ^ Mouse PubMed Reference: ^ Duncan Hughes, Joseph B. Guttenplan, Craig B. Marcus, Kotha Subbaramaiah and Andrew J. 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