非特異的モノオキシゲナーゼ

非特異的モノオキシゲナーゼ（unspecific monooxygenase）は、次の化学反応を触媒する酸化還元酵素である。 R-H + 還元型フラボタンパク質 + O2 ⇌ {\displaystyle \rightleftharpoons } ROH + 酸化型フラボタンパク質 + H2O この酵素の基質はR-H、還元型フラボタンパク質とO2で、生成物はR-OH、酸化型フラボタンパク質、H2Oである。補因子としてヘムを用いる。 組織名はsubstrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)で、別名にmicrosomal monooxygenase、xenobiotic monooxygenase、aryl-4-monooxygenase、aryl hydrocarbon hydroxylase、microsomal P-450、flavoprotein-linked monooxygenase、flavoprotein monooxygenaseがある。 BOOTH J, BOYLAND E (1957). “The biochemistry of aromatic amines. III. Enzymic hydroxylation by rat-liver microsomes”. Biochem. J. 66 (1): 73–8. PMC 1199967. PMID 13426111. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1199967/.  Fujita T, Mannering GJ (1971). “Differences in soluble P-450 hemoproteins from livers of rats treated with phenobarbital and 3-methylcholanthrene”. Chem. Biol. Interact. 3 (4): 264–5. doi:10.1016/0009-2797(71)90053-6. PMID 5132997.  Haugen DA, Coon MJ (1976). “Properties of electrophoretically homogeneous phenobarbital-inducible and beta-naphthoflavone-inducible forms of liver microsomal cytochrome P-450”. J. Biol. Chem. 251 (24): 7929–39. PMID 187601.  Imaoka S, Inoue K, Funae Y (1988). “Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography”. Arch. Biochem. Biophys. 265 (1): 159–70. doi:10.1016/0003-9861(88)90381-5. PMID 3415241.  Johnson EF, Zounes MC, Muller-Eberhard U (1979). “Characterization of three forms of rabbit microsomal cytochrome P-450 by peptide mapping utilizing limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis”. Arch. Biochem. Biophys. 192 (1): 282–9. doi:10.1016/0003-9861(79)90093-6. PMID 434823.  Kupfer D, Miranda GK, Navarro J, Piccolo DE, Theoharides AD (1979). “Effect of inducers and inhibitors of monooxygenase on the hydroxylation of prostaglandins in the guinea pig. Evidence for several monooxygenases catalyzing omega- and omega-1-hydroxylation”. J. Biol. Chem. 254 (20): 10405–14. PMID 489601.  Lang MA, Gielen JE, Nebert DW (1981). “Genetic evidence for many unique liver microsomal P-450-mediated monooxygenase activities in heterogeneic stock mice”. J. Biol. Chem. 256 (23): 12068–75. PMID 7298645.  Lang MA, Nebert DW (1981). “Structural gene products of the Ah locus. Evidence for many unique P-450-mediated monooxygenase activities reconstituted from 3-methylcholanthrene-treated C57BL/6N mouse liver microsomes”. J. Biol. Chem. 256 (23): 12058–67. PMID 7298644.  Leo MA, Lasker JM, Raucy JL, Kim CI, Black M, Lieber CS (1989). “Metabolism of retinol and retinoic acid by human liver cytochrome P450IIC8”. Arch. Biochem. Biophys. 269 (1): 305–12. doi:10.1016/0003-9861(89)90112-4. PMID 2916844.  Lu AY, Kuntzman R, West S, Jacobson M, Conney AH (1972). “Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. II. Role of the cytochrome P-450 and P-448 fractions in drug and steroid hydroxylations”. J. Biol. Chem. 247 (6): 1727–34. PMID 4401153.  MITOMA C, POSNER HS, REITZ HC, UDENFRIEND S (1956). “Enzymatic hydroxylation of aromatic compounds”. Arch. Biochem. Biophys. 61 (2): 431–41. doi:10.1016/0003-9861(56)90366-6. PMID 13314626.  Mitoma C and Udenfriend S (1962). “Aryl-4-hydroxylase”. Methods Enzymol. 5: 816–819.  Napoli JL, Okita RT, Masters BS, Horst RL (1981). “Identification of 25,26-dihydroxyvitamin D3 as a rat renal 25-hydroxyvitamin D3 metabolite”. Biochemistry. 20 (20): 5865–71. doi:10.1021/bi00523a033. PMID 7295706.  Nebert DW, Gelboin HV (1968). “Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. I. Assay and properties of induced enzyme”. J. Biol. Chem. 243 (23): 6242–9. PMID 4387094.  Suhara K, Ohashi K, Takahashi K, Katagiri M (1988). “Aromatase and nonaromatizing 10-demethylase activity of adrenal cortex mitochondrial P-450(11)beta”. Arch. Biochem. Biophys. 267 (1): 31–7. doi:10.1016/0003-9861(88)90004-5. PMID 3264134.  Theoharides AD, Kupfer D (1981). “Evidence for different hepatic microsomal monooxygenases catalyzing omega- and (omega-1)-hydroxylations of prostaglandins E1 and E2 Effects of inducers of monooxygenase on the kinetic constants of prostaglandin hydroxylation”. J. Biol. Chem. 256 (5): 2168–75. PMID 7462235.  Thomas PE, Lu AY, Ryan D, West SB, Kawalek J, Levin W (1976). “Immunochemical evidence for six forms of rat liver cytochrome P450 obtained using antibodies against purified rat liver cytochromes P450 and P448”. Mol. Pharmacol. 12 (5): 746–58. PMID 825720.