ミニ染色体維持複合体成分2

ミニ染色体維持複合体成分2（MCM2: minichromosome maintenance complex component 2）あるいはDNA複製ライセンス化因子MCM2（DNA replication licensing factor MCM2）は、ヒトではMCM2遺伝子によってコードされるタンパク質である。 MCM2は、真核生物のDNA複製の開始に関与する高度に保存されたミニ染色体維持複合体（MCM）の6つの構成タンパク質のうちの一つである。MCMは、複製前複合体（pre-RC）の重要な構成要素であり、複製フォークの形成や他のDNA複製関連タンパク質の動員に関与していると考えられている。MCM2は、他のMCM成分であるMCM4、MCM6、及びMCM7と結合し、MCMのDNAヘリカーゼ活性を調節することが示されている。このタンパク質はリン酸化を受けて活性化するため、プロテインキナーゼであるCDC2およびCDC7によって調節される。 MCM2は、以下の生体分子と相互作用する。 AKAP8 CDC7関連タンパク質キナーゼ MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC2 ORC4 ORC5 複製タンパク質A1 ^ a b c GRCh38: Ensembl release 89: ENSG00000073111 - Ensembl, May 2017 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002870 - Ensembl, May 2017 ^ Human PubMed Reference: ^ Mouse PubMed Reference: ^ “Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle”. Biochem Biophys Res Commun 177 (1): 395–400. (Jul 1991). doi:10.1016/0006-291X(91)91996-P. 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