サイクリンC

サイクリンC（英: cyclin C）は、ヒトではCCNC遺伝子にコードされるタンパク質である。 CCNC遺伝子にコードされるサイクリンCは、サイクリンファミリーに属するタンパク質である。サイクリンCはサイクリン依存性キナーゼ8（英語版）と相互作用し、RNAポリメラーゼIIの大サブユニットのC末端ドメインのリン酸化を誘導する。この遺伝子のmRNAレベルは細胞周期のG1期にピークに達する。この遺伝子には異なるアイソフォームをコードする2つの転写バリアントが見つかっている。 サイクリンCはエストロゲン受容体α、サイクリン依存性キナーゼ8（英語版）と相互作用することが示されている。 ^ a b c GRCh38: Ensembl release 89: ENSG00000112237 - Ensembl, May 2017 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028252 - Ensembl, May 2017 ^ Human PubMed Reference: ^ Mouse PubMed Reference: ^ “Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast”. Cell 66 (6): 1197–206. (Oct 1991). doi:10.1016/0092-8674(91)90042-W. PMID 1833066.  ^ a b “Entrez Gene: CCNC cyclin C”. 2021年11月22日閲覧。 ^ a b Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). “The TRAP/Mediator coactivator complex interacts directly with estrogen receptors α and β through the TRAP220 subunit and directly enhances estrogen receptor function in vitro”. Proc. Natl. Acad. 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PMID 12600719.  Human CCNC genome location and CCNC gene details page in the UCSC Genome Browser.