ミトコンドリアフェリチン

ミトコンドリアフェリチン（Mitochondrial ferritin）とはフェロキシダーゼの一種である。ヒトにおいてはFTMT 遺伝子にコードされている。 ミトコンドリアに存在する金属結合性タンパク質である。ミトコンドリアフェリチンはタンパク質前駆体であり、ミトコンドリアに取り込まれた際にプレセシングされて成熟タンパク質となる。そして、フェリチンとなる。 182個の残基から成る。主にαヘリックスから成り、βシートは少ない。構造の67%はヘリックスである。 ^ a b c GRCh38: Ensembl release 89: ENSG00000181867 - Ensembl, May 2017 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024510 - Ensembl, May 2017 ^ Human PubMed Reference: ^ Mouse PubMed Reference: ^ “A human mitochondrial ferritin encoded by an intronless gene”. J. Biol. Chem. 276 (27): 24437–40. (July 2001). doi:10.1074/jbc.C100141200. PMID 11323407.  ^ Langlois d'Estaintot, B., Santambrogio, P., Granier, T., Gallois, B., Chevallier, J.M., Precigoux, G., Levi, S., Arosio, P. (2 July 2004). “Crystal Structure and Biochemical Properties of the Human Mitochondrial Ferritin and its Mutant Ser144Ala”. Journal of Molecular Biology 340 (2): 277-293. doi:10.1016/j.jmb.2004.04.036. 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