NADPH-ヘムタンパク質レダクターゼ

NADPH-ヘムタンパク質レダクターゼ(NADPH-hemoprotein reductase)は、次の化学反応を触媒する酸化還元酵素である。 NADPH + H+ + 酸化型ヘムタンパク質 ⇌ {\displaystyle \rightleftharpoons } NADP+ + 還元型ヘムタンパク質 反応式の通り、この酵素の基質はNADPHとH+と酸化型ヘムタンパク質、生成物はNADP+と還元型ヘムタンパク質である。 組織名はNADPH:hemoprotein oxidoreductaseで、別名にCPR; FAD-cytochrome c reductase; NADP—cytochrome c reductase; NADP—cytochrome reductase; NADPH-dependent cytochrome c reductase; NADPH:P-450 reductase; NADPH:ferrihemoprotein oxidoreductase; NADPH—cytochrome P-450 oxidoreductase; NADPH—cytochrome c oxidoreductase; NADPH—cytochrome c reductase; NADPH—cytochrome p-450 reductase; NADPH—ferricytochrome c oxidoreductase; NADPH—ferrihemoprotein reductase; TPNH2 cytochrome c reductase; TPNH-cytochrome c reductase; aldehyde reductase (NADPH-dependent); cytochrome P-450 reductase; cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent); dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase; ferrihemoprotein P-450 reductase; reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase; reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate)がある。 Haas E, Horecker BL and Hogness TR (1940). “The enzymatic reduction of cytochrome c, cytochrome c reductase”. J. Biol. Chem. 136: 747–774.  Horecker BL (1950). “Triphosphopyridine nucleotide-cytochrome c reductase in liver”. J. Biol. Chem. 183: 593–605.  Lu AY, Junk KW, Coon MJ (1969). “Resolution of the cytochrome P-450-containing omega-hydroxylation system of liver microsomes into three components”. J. Biol. Chem. 244: 3714–21. PMID 4389465.  GIBSON QH, PALMER G, WHARTON DC (1965). “STUDIES ON THE MECHANISM OF MICROSOMAL TRIPHOSPHOPYRIDINE NUCLEOTIDE-CYTOCHROME C REDUCTASE”. J. Biol. Chem. 240: 921–31. PMID 14275154.  WILLIAMS CH Jr, KAMIN H (1962). “Microsomal triphosphopyridine nucleotide-cytochrome c reductase of liver”. J. Biol. Chem. 237: 587–95. PMID 14007123.  Masters BS, Bilimoria MH, Kamin H, Gibson QH (1965). “The mechanism of 1- and 2-electron transfers catalyzed by reduced triphosphopyridine nucleotide-cytochrome c reductase”. J. Biol. Chem. 240: 4081–8. PMID 4378860.  Sevrioukova IF, Peterson JA (1995). “NADPH-P-450 reductase: structural and functional comparisons of the eukaryotic and prokaryotic isoforms”. Biochimie. 77: 562–72. doi:10.1016/0300-9084(96)88172-7. PMID 8589067.  Wang M, Roberts DL, Paschke R, Shea TM, Masters BS, Kim JJ (1997). “Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes”. Proc. Natl. Acad. Sci. U. S. A. 94: 8411–6. doi:10.1073/pnas.94.16.8411. PMID 9237990.  Munro AW, Noble MA, Robledo L, Daff SN, Chapman SK (2001). “Determination of the redox properties of human NADPH-cytochrome P450 reductase”. Biochemistry. 40: 1956–63. doi:10.1021/bi001718u. PMID 11329262.  Munro AW, Noble MA, Robledo L, Daff SN, Chapman SK (2001). “Determination of the redox properties of human NADPH-cytochrome P450 reductase”. Biochemistry. 40: 1956–63. doi:10.1021/bi001718u. PMID 11329262.  Scrutton NS (2003). “Electron transfer in human cytochrome P450 reductase”. Biochem. Soc. Trans. 31: 497–501. doi:10.1042/BST0310497. PMID 12773143.  Scrutton NS (2003). “Electron transfer in human cytochrome P450 reductase”. Biochem. Soc. Trans. 31: 497–501. doi:10.1042/BST0310497. PMID 12773143.