サイクリンB2

サイクリンB2（英: cyclin B2）は、ヒトではCCNB2遺伝子にコードされるタンパク質である。 サイクリンB2はサイクリンファミリーのメンバー、より具体的にはB型サイクリンである。B型サイクリンであるB1、B2はp34（CDK1）と結合し、細胞周期調節装置の必要不可欠な構成要素である。B1とB2は細胞内局在が異なる。サイクリンB1は微小管と共局在するのに対し、サイクリンB2はゴルジ体領域に結合している。サイクリンB2はTGFBR2（英語版）と結合するため、TGF-βを介した細胞周期の制御に重要な役割を果たしている可能性がある。 サイクリンB2はTGFBR2（英語版）と相互作用することが示されている。 ^ a b c GRCh38: Ensembl release 89: ENSG00000157456 - Ensembl, May 2017 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032218 - Ensembl, May 2017 ^ Human PubMed Reference: ^ Mouse PubMed Reference: ^ “Entrez Gene: CCNB2 cyclin B2”. 2022年1月30日閲覧。 ^ “Functional association of TGF-beta receptor II with cyclin B”. Oncogene 18 (1): 269–75. (Jan 1999). doi:10.1038/sj.onc.1202263. PMID 9926943.  “Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity”. J. Virol. 69 (11): 6705–11. (1995). doi:10.1128/JVI.69.11.6705-6711.1995. PMC 189580. PMID 7474080. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC189580/.  “Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B”. J. Virol. 69 (11): 6859–64. (1995). doi:10.1128/JVI.69.11.6859-6864.1995. PMC 189600. PMID 7474100. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC189600/.  “Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr”. J. Virol. 69 (12): 7909–16. (1995). doi:10.1128/JVI.69.12.7909-7916.1995. PMC 189735. PMID 7494303. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC189735/.  “The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle”. J. Virol. 69 (10): 6304–13. (1995). doi:10.1128/JVI.69.10.6304-6313.1995. PMC 189529. PMID 7666531. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC189529/.  “Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus”. EMBO J. 14 (8): 1646–54. (1995). doi:10.1002/j.1460-2075.1995.tb07153.x. PMC 398257. PMID 7737117. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC398257/.  “The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B”. EMBO J. 13 (16): 3772–81. (1994). doi:10.1002/j.1460-2075.1994.tb06688.x. PMC 395290. PMID 8070405. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC395290/.  “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene 138 (1–2): 171–4. (1994). doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  “Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard”. J. Virol. 71 (5): 3961–71. (1997). doi:10.1128/JVI.71.5.3961-3971.1997. PMC 191548. PMID 9094673. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC191548/.  “Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”. Gene 200 (1–2): 149–56. (1997). doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  “HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle”. Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3419–24. (1998). doi:10.1073/pnas.95.7.3419. PMC 19851. PMID 9520381. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC19851/.  “Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero”. Proc. Natl. Acad. Sci. U.S.A. 95 (8): 4344–9. (1998). doi:10.1073/pnas.95.8.4344. PMC 22491. PMID 9539739. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC22491/.  “HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator”. Proc. Natl. Acad. Sci. U.S.A. 95 (9): 5281–6. (1998). doi:10.1073/pnas.95.9.5281. PMC 20252. PMID 9560267. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20252/.  “Functional association of TGF-beta receptor II with cyclin B”. Oncogene 18 (1): 269–75. (1999). doi:10.1038/sj.onc.1202263. PMID 9926943.  “Cell cycle G2 arrest induced by HIV-1 Vpr in fission yeast (Schizosaccharomyces pombe) is independent of cell death and early genes in the DNA damage checkpoint”. Virus Res. 68 (2): 161–73. (2000). doi:10.1016/S0168-1702(00)00167-2. PMID 10958988.  “DNA cloning using in vitro site-specific recombination”. Genome Res. 10 (11): 1788–95. (2000). doi:10.1101/gr.143000. PMC 310948. PMID 11076863. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310948/.  “Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs”. Genome Res. 11 (3): 422–35. (2001). doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311072/.  “Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing”. EMBO Rep. 1 (3): 287–92. (2000). doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1083732/.  “HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25”. Virology 287 (2): 359–70. (2001). doi:10.1006/viro.2001.1007. PMID 11531413.  “Hypophosphorylation of poly(A) polymerase and increased polyadenylation activity are associated with human immunodeficiency virus type 1 Vpr expression”. Virology 292 (2): 321–30. (2002). doi:10.1006/viro.2001.1261. PMID 11878934.  サイクリンB 表示 編集