EZH1

ヒストン-リジン-N-メチルトランスフェラーゼEZH1（enhancer of zeste homolog 1）は、ヒトではEZH1遺伝子にコードされるタンパク質である。 マウスでは、EZH1とEZH2は共にヒストンH3K27のトリメチル化を司り、毛包の恒常性と創傷治癒に必要不可欠である。またEZH1は、幹細胞の同一性の維持と多能性の発揮に関するEZH2の機能を補完する。 ^ a b c GRCh38: Ensembl release 89: ENSG00000108799 - Ensembl, May 2017 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006920 - Ensembl, May 2017 ^ Human PubMed Reference: ^ Mouse PubMed Reference: ^ “Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1”. Genomics 37 (2): 161–71. (Feb 1997). doi:10.1006/geno.1996.0537. PMID 8921387.  ^ “Entrez Gene: EZH1 enhancer of zeste homolog 1 (Drosophila)”. 2021年9月5日閲覧。 ^ “EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair.”. Genes Dev. 25 (5): 485–98. (Mar 2011). doi:10.1101/gad.2019811. PMC 3049289. PMID 21317239. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049289/.  ^ “EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.”. Mol Cell 32 (4): 491–502. (Nov 2008). doi:10.1016/j.molcel.2008.10.016. PMC 2630502. PMID 19026780. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630502/.  “Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21.”. Genomics 28 (3): 530–42. (1996). doi:10.1006/geno.1995.1185. PMID 7490091.  “Construction of a transcription map surrounding the BRCA1 locus of human chromosome 17.”. Genomics 25 (1): 238–47. (1995). doi:10.1016/0888-7543(95)80131-5. PMID 7774924. https://zenodo.org/record/1258609.  “Direct selection of expressed sequences within a 1-Mb region flanking BRCA1 on human chromosome 17q21.”. Genomics 25 (1): 248–55. (1995). doi:10.1016/0888-7543(95)80132-6. PMID 7774925.  “22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors.”. Genomics 25 (1): 256–63. (1995). doi:10.1016/0888-7543(95)80133-7. PMID 7774926.  “Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.”. DNA Res. 4 (2): 141–50. (1997). doi:10.1093/dnares/4.2.141. PMID 9205841.  “Cloning and expression of a human/mouse Polycomb group gene, ENX-2/Enx-2.”. Biochim. Biophys. Acta 1395 (2): 151–8. (1998). doi:10.1016/s0167-4781(97)00156-5. PMID 9473645.  “The Drosophila esc and E(z) proteins are direct partners in polycomb group-mediated repression.”. Mol. Cell. Biol. 18 (5): 2825–34. (1998). doi:10.1128/mcb.18.5.2825. PMC 110661. PMID 9566901. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110661/.  “Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes.”. Mol. Cell. Biol. 18 (6): 3572–9. (1998). doi:10.1128/MCB.18.6.3572. PMC 108938. PMID 9584197. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC108938/.  “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. (2003). doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.  “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. (2004). doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/.  表示 編集