ラディキシン

ラディキシン(Radixin)は、ヒトではRDX遺伝子によりコードされるタンパク質である。モエシン、エズリンとともにERMファミリーを構成する。 ラディキシンは細胞骨格タンパク質で、アクチンと細胞膜の結合に重要な役割を果たしている可能性がある。エズリンやモエシンと高度の配列類似性がみられる。RDX遺伝子は11q23に位置することが蛍光 in situ ハイブリダイゼーションにより特定されている。不完全なものをコードする偽遺伝子(RDXP2)がXp21.3に、イントロンを欠く別の偽遺伝子(RDXP1)が11pに存在する。 ラディキシンは、GNA13とタンパク質間相互作用する。 ^ a b c GRCh38: Ensembl release 89: ENSG00000137710 - Ensembl, May 2017 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032050 - Ensembl, May 2017 ^ Human PubMed Reference: ^ Mouse PubMed Reference: ^ “Molecular cloning, cDNA sequence, and chromosomal assignment of the human radixin gene and two dispersed pseudogenes”. Genomics 16 (1): 199-206. (June 1993). doi:10.1006/geno.1993.1159. PMID 8486357.  ^ “Mutations of the RDX gene cause nonsyndromic hearing loss at the DFNB24 locus”. Hum Mutat 28 (5): 417-23. (April 2007). doi:10.1002/humu.20469. PMID 17226784.  ^ a b “Entrez Gene: RDX radixin”. 2020年3月31日閲覧。 ^ “Conformational activation of radixin by G13 protein alpha subunit”. J. Biol. 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