セレブロシドスルファターゼ

セレブロシドスルファターゼ(Cerebroside-sulfatase)またはアリールスルファターゼA(Arylsulfatase A)は、セレブロシド-3-硫酸をセレブロシドと硫酸に分解する酵素である。ヒトでは、アリールスルファターゼAはARSA遺伝子でコードされている。 欠乏は、異染性白質ジストロフィーと関連している。 ^ a b c GRCh38: Ensembl release 89: ENSG00000100299 - Ensembl, May 2017 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022620 - Ensembl, May 2017 ^ Human PubMed Reference: ^ Mouse PubMed Reference: ^ Stein C, Gieselmann V, Kreysing J, Schmidt B, Pohlmann R, Waheed A, Meyer HE, O'Brien JS, von Figura K (January 1989). “Cloning and expression of human arylsulfatase A”. J. Biol. Chem. 264 (2): 1252–9. PMID 2562955.  ^ Matzner U, Herbst E, Hedayati KK, Lüllmann-Rauch R, Wessig C, Schröder S, Eistrup C, Möller C, Fogh J, Gieselmann V (May 2005). “Enzyme replacement improves nervous system pathology and function in a mouse model for metachromatic leukodystrophy”. Hum. Mol. Genet. 14 (9): 1139–52. doi:10.1093/hmg/ddi126. 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