核内受容体コアクチベーター1

核内受容体コアクチベーター1 （NCOA1: nuclear receptor coactivator 1）は、いくつかの核内受容体相互作用ドメインと固有のヒストンアセチルトランスフェラーゼ活性を含む転写共調節タンパク質である。 NCOA1は、リガンドで活性化される核内受容体によってDNAプロモーター部位に動員される。次に、NCOA1はヒストンをアシル化し、下流のDNAを転写しやすくする。したがって、NCOA1はDNA発現の上方調節において核内受容体を援助する。 NCOA1は、ステロイド受容体コアクチベーター1（SRC-1: steroid receptor coactivator-1）と同一である。 NCOA1は、塩基性ヘリックスループヘリックス（bHLH）ドメインを有しており、以下の生体分子と相互作用することができる。 アンドロゲン受容体 C-Fos C-jun CIITA CREB結合タンパク質 サイクリンD1 DDX17 DDX5 エストロゲン受容体α 糖質コルチコイド受容体 NFKB1 PCAF PPARGC1A ペルオキシソーム増殖因子活性化受容体α SNW1 STAT3 STAT6 TRIP4 甲状腺ホルモン受容体β ^ a b c GRCh38: Ensembl release 89: ENSG00000084676 - Ensembl, May 2017 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020647 - Ensembl, May 2017 ^ Human PubMed Reference: ^ Mouse PubMed Reference: ^ Sergio A. Oñate, Sophia Y. Tsai, Ming-Jer Tsai, Bert W. O'Malley (24 Nov 1995). “Sequence and characterization of a coactivator for the steroid hormone receptor superfamily”. Science 270 (5240): 1354–1357. doi:10.1126/science.270.5240.1354. PMID 7481822.  ^ Sergio A. 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PMID 9171239.  nuclear receptor coactivator 1 - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス（英語） NURSA C89 “Peroxisome proliferator-activated receptors, coactivators, and downstream targets”. Cell Biochemistry and Biophysics. 32 Spring (1–3): 187–204. (2001). doi:10.1385/cbb:32:1-3:187. PMID 11330046.