ARAF

セリン/トレオニンタンパク質キナーゼ A-Raf（セリン/トレオニン-タンパクしつキナーゼ・エイラフ、英: Serine/threonine-protein kinase A-Raf）あるいは単純にA-Rafは、ヒトARAF遺伝子にコードされている酵素である。A-Rafはセリン/トレオニン特異的タンパク質キナーゼ（英語版）のRafキナーゼファミリーのメンバーである。 ARAFは以下のタンパク質と相互作用することが示されている。 EFEMP1 MAP2K2 PRPF6 RRAS TIMM44 TH1L ^ a b c GRCh38: Ensembl release 89: ENSG00000078061 - Ensembl, May 2017 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001127 - Ensembl, May 2017 ^ Human PubMed Reference: ^ Mouse PubMed Reference: ^ “Entrez Gene: ARAF V-raf murine sarcoma 3611 viral oncogene homolog”. 2012年1月26日閲覧。 ^ Mark GE, Seeley TW, Shows TB, Mountz JD (September 1986). “Pks, a raf-related sequence in humans”. Proc. Natl. Acad. Sci. U.S.A. 83 (17): 6312–6. doi:10.1073/pnas.83.17.6312. PMC 386493. PMID 3529082. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC386493/.  ^ a b c d e Yuryev A, Wennogle LP (February 2003). “Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis”. 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(1997). “Large-Scale Concatenation cDNA Sequencing”. Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139146/.  Yuryev A, Ono M, Goff SA, et al. (2000). “Isoform-Specific Localization of A-RAF in Mitochondria”. Mol. Cell. Biol. 20 (13): 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. PMC 85938. PMID 10848612. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC85938/.  King TR, Fang Y, Mahon ES, Anderson DH (2000). “Using a phage display library to identify basic residues in A-Raf required to mediate binding to the Src homology 2 domains of the p85 subunit of phosphatidylinositol 3'-kinase”. J. Biol. Chem. 275 (46): 36450–6. doi:10.1074/jbc.M004720200. PMID 10967104.  Fang Y, Johnson LM, Mahon ES, Anderson DH (2002). “Two phosphorylation-independent sites on the p85 SH2 domains bind A-Raf kinase”. Biochem. Biophys. Res. Commun. 290 (4): 1267–74. doi:10.1006/bbrc.2002.6347. PMID 11812000.  Yin XL, Chen S, Yan J, et al. (2002). “Identification of interaction between MEK2 and A-Raf-1”. Biochim. Biophys. Acta 1589 (1): 71–6. doi:10.1016/S0167-4889(01)00188-4. PMID 11909642.  Yin XL, Chen S, Gu JX (2002). “Identification of TH1 as an interaction partner of A-Raf kinase”. Mol. Cell. Biochem. 231 (1–2): 69–74. doi:10.1023/A:1014437024129. PMID 11952167.  Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.  Yuryev A, Wennogle LP (2003). “Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis”. Genomics 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389.  Liu W, Shen X, Yang Y, et al. (2004). “Trihydrophobin 1 is a new negative regulator of A-Raf kinase”. J. Biol. 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