IRS2

IRS2（insulin receptor substrate 2、インスリン受容体基質2）は、ヒトではIRS2遺伝子によってコードされるタンパク質である。 IRS2遺伝子はIRS２タンパク質をコードする。IRS2は細胞質のシグナル伝達分子であり、多様な受容体型チロシンキナーゼと下流のエフェクター分子との間のアダプタータンパク質として、インスリン、IGF-1や他のサイトカインの効果を媒介する。IRS2はインスリン受容体の刺激に伴ってリン酸化されるほか、IL-4処理に応答してIL-4受容体関連キナーゼによってもリン酸化される。 IRS2を欠失したマウスは糖尿病の表現型を示すとともに、脳の重量が40％低下する。 IRS2は次に挙げる因子と相互作用することが示されている。 PLCG1（英語版） SOCS1（英語版） PIK3R1（英語版） ^ a b c GRCh38: Ensembl release 89: ENSG00000185950 - Ensembl, May 2017 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038894 - Ensembl, May 2017 ^ Human PubMed Reference: ^ Mouse PubMed Reference: ^ “14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain”. J Biol Chem 272 (40): 25267–74. (Oct 1997). doi:10.1074/jbc.272.40.25267. PMID 9312143.  ^ “Entrez Gene: IRS2 insulin receptor substrate 2”. 2021年9月7日閲覧。 ^ “Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes”. J. Clin. Invest. 114 (7): 908–16. 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