STAT1

STAT1是转录因子中信号转导及转录激活蛋白（STAT蛋白）家族的一员。 STAT1涉及I型、II型或III型干扰素激活基因的正调控。在干扰素-γ刺激下，STAT1会组成同源二聚体或与STAT3组成异二聚体结合到GAS（Interferon-Gamma-Activated Sequence，干扰素γ激活序列）启动子上；而在干扰素-α或干扰素-β刺激下，STAT1会与STAT2组成异二聚体结合到ISRE（Interferon-Stimulated Response Element，干扰素激活反应元件）启动子上。在这两种情况下，STAT二聚体与启动子的结合都会导致ISG（Interferon-Stimulated Genes，干扰素激活基因）的表达。 STAT1可由二烯丙基二硫诱导表达 STAT1能与下列蛋白质发生相互作用： 蛋白激酶R（英语：Protein kinase R） Src IRF1 STAT3 MCM5 STAT2 CD117 Fanconi anemia, complementation group C CREB结合蛋白（英语：CREB-binding protein） 白介素27受体α亚基（英语：Interleukin 27 receptor, alpha subunit） PIAS1 BRCA1 表皮生长因子受体 PTK2 Mammalian target of rapamycin IFNAR2 PRKCD TRADD C-jun Calcitriol receptor ISGF3G GNB2L1 與STAT1相關的疾病；在維基數據上查看/編輯參考.  GRCh38: Ensembl release 89: ENSG00000115415 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000026104 - Ensembl, May 2017 Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Mouse PubMed Reference:. 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PMID 9344858. doi:10.1006/bbrc.1997.7493.  引文使用过时参数coauthors (帮助) Chatterjee-Kishore, M; van Den Akker F, Stark G R. Adenovirus E1A down-regulates LMP2 transcription by interfering with the binding of stat1 to IRF1. J. Biol. Chem. (United States). July 2000, 275 (27): 20406–11. ISSN 0021-9258. PMID 10764778. doi:10.1074/jbc.M001861200.  引文使用过时参数coauthors (帮助) Gunaje, J J; Bhat G J. Involvement of tyrosine phosphatase PTP1D in the inhibition of interleukin-6-induced Stat3 signaling by alpha-thrombin. Biochem. Biophys. Res. Commun. (United States). October 2001, 288 (1): 252–7. ISSN 0006-291X. PMID 11594781. doi:10.1006/bbrc.2001.5759.  引文使用过时参数coauthors (帮助) Spiekermann, K; Biethahn S, Wilde S, Hiddemann W, Alves F. Constitutive activation of STAT transcription factors in acute myelogenous leukemia. Eur. J. Haematol. (Denmark). August 2001, 67 (2): 63–71. ISSN 0902-4441. PMID 11722592.  引文使用过时参数coauthors (帮助) Xia, Ling; Wang Lijuan, Chung Alicia S, Ivanov Stanimir S, Ling Mike Y, Dragoi Ana M, Platt Adam, Gilmer Tona M, Fu Xin-Yuan, Chin Y Eugene. Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation. J. Biol. Chem. (United States). August 2002, 277 (34): 30716–23. ISSN 0021-9258. PMID 12070153. doi:10.1074/jbc.M202823200.  引文使用过时参数coauthors (帮助) Zhang, J J; Zhao Y, Chait B T, Lathem W W, Ritzi M, Knippers R, Darnell J E. Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation. EMBO J. (ENGLAND). Dec 1998, 17 (23): 6963–71. ISSN 0261-4189. PMC 1171044 . PMID 9843502. doi:10.1093/emboj/17.23.6963.  引文使用过时参数coauthors (帮助) DaFonseca, C J; Shu F, Zhang J J. Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma. Proc. Natl. Acad. Sci. U.S.A. (United States). March 2001, 98 (6): 3034–9. ISSN 0027-8424. PMC 30602 . PMID 11248027. doi:10.1073/pnas.061487598.  引文使用过时参数coauthors (帮助) Li, X; Leung S, Qureshi S, Darnell J E, Stark G R. Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha. J. Biol. Chem. (United States). March 1996, 271 (10): 5790–4. ISSN 0021-9258. PMID 8621447. doi:10.1074/jbc.271.10.5790.  引文使用过时参数coauthors (帮助) Dumler, I; Kopmann A, Wagner K, Mayboroda O A, Jerke U, Dietz R, Haller H, Gulba D C. Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells. J. Biol. Chem. (United States). August 1999, 274 (34): 24059–65. ISSN 0021-9258. PMID 10446176. doi:10.1074/jbc.274.34.24059.  引文使用过时参数coauthors (帮助) Fagerlund, Riku; Mélen Krister, Kinnunen Leena, Julkunen Ilkka. Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5. J. Biol. Chem. (United States). August 2002, 277 (33): 30072–8. ISSN 0021-9258. PMID 12048190. doi:10.1074/jbc.M202943200.  引文使用过时参数coauthors (帮助) Deberry, C; Mou S, Linnekin D. Stat1 associates with c-kit and is activated in response to stem cell factor. Biochem. J. (ENGLAND). October 1997, 327 (1): 73–80. ISSN 0264-6021. PMC 1218765 . PMID 9355737.  引文使用过时参数coauthors (帮助) Pang, Q; Fagerlie S, Christianson T A, Keeble W, Faulkner G, Diaz J, Rathbun R K, Bagby G C. The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors. Mol. Cell. Biol. (United States). July 2000, 20 (13): 4724–35. ISSN 0270-7306. PMC 85895 . PMID 10848598. doi:10.1128/MCB.20.13.4724-4735.2000.  引文使用过时参数coauthors (帮助) Reuter, Tanja Y; Medhurst Annette L, Waisfisz Quinten, Zhi Yu, Herterich Sabine, Hoehn Holger, Gross Hans J, Joenje Hans, Hoatlin Maureen E, Mathew Christopher G, Huber Pia A J. Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. Exp. Cell Res. (United States). October 2003, 289 (2): 211–21. ISSN 0014-4827. PMID 14499622. doi:10.1016/S0014-4827(03)00261-1.  引文使用过时参数coauthors (帮助) Pang, Q; Christianson T A, Keeble W, Diaz J, Faulkner G R, Reifsteck C, Olson S, Bagby G C. The Fanconi anemia complementation group C gene product: structural evidence of multifunctionality. Blood (United States). September 2001, 98 (5): 1392–401. ISSN 0006-4971. PMID 11520787. doi:10.1182/blood.V98.5.1392.  引文使用过时参数coauthors (帮助) Zhang, J J; Vinkemeier U, Gu W, Chakravarti D, Horvath C M, Darnell J E. Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling. Proc. Natl. Acad. Sci. U.S.A. (United States). Dec 1996, 93 (26): 15092–6. ISSN 0027-8424. PMC 26361 . PMID 8986769. doi:10.1073/pnas.93.26.15092.  引文使用过时参数coauthors (帮助) Takeda, Atsunobu; Hamano Shinjiro, Yamanaka Atsushi, Hanada Toshikatsu, Ishibashi Tatsuro, Mak Tak W, Yoshimura Akihiko, Yoshida Hiroki. Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J. Immunol. (United States). May 2003, 170 (10): 4886–90. ISSN 0022-1767. PMID 12734330.  引文使用过时参数coauthors (帮助) Liao, J; Fu Y, Shuai K. Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction. Proc. Natl. Acad. Sci. U.S.A. (United States). May 2000, 97 (10): 5267–72. ISSN 0027-8424. PMC 25817 . PMID 10805787. doi:10.1073/pnas.97.10.5267.  引文使用过时参数coauthors (帮助) Ouchi, T; Lee S W, Ouchi M, Aaronson S A, Horvath C M. Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes. Proc. Natl. Acad. Sci. U.S.A. (United States). May 2000, 97 (10): 5208–13. ISSN 0027-8424. PMC 25807 . PMID 10792030. doi:10.1073/pnas.080469697.  引文使用过时参数coauthors (帮助) Xie, B; Zhao J, Kitagawa M, Durbin J, Madri J A, Guan J L, Fu X Y. Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion. J. Biol. Chem. (United States). June 2001, 276 (22): 19512–23. ISSN 0021-9258. PMID 11278462. doi:10.1074/jbc.M009063200.  引文使用过时参数coauthors (帮助) Kristof, Arnold S; Marks-Konczalik Joanna, Billings Eric, Moss Joel. Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-gamma is regulated by mammalian target of rapamycin. J. Biol. Chem. (United States). September 2003, 278 (36): 33637–44. ISSN 0021-9258. PMID 12807916. doi:10.1074/jbc.M301053200.  引文使用过时参数coauthors (帮助) Li, X; Leung S, Kerr I M, Stark G R. Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. Mol. Cell. Biol. (United States). April 1997, 17 (4): 2048–56. ISSN 0270-7306. PMC 232052 . PMID 9121453.  引文使用过时参数coauthors (帮助) Usacheva, A; Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O. The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor. J. Biol. Chem. (United States). June 2001, 276 (25): 22948–53. ISSN 0021-9258. PMID 11301323. doi:10.1074/jbc.M100087200.  引文使用过时参数coauthors (帮助) Wang, Y; Wu T R, Cai S, Welte T, Chin Y E. Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation. Mol. Cell. Biol. (United States). July 2000, 20 (13): 4505–12. ISSN 0270-7306. PMC 85828 . PMID 10848577. doi:10.1128/MCB.20.13.4505-4512.2000.  引文使用过时参数coauthors (帮助) Zhang, X; Wrzeszczynska M H, Horvath C M, Darnell J E. Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation. Mol. Cell. Biol. (United States). October 1999, 19 (10): 7138–46. ISSN 0270-7306. PMC 84707 . PMID 10490649.  引文使用过时参数coauthors (帮助) Vidal, Marcos; Ramana Chilakamarti V, Dusso Adriana S. Stat1-vitamin D receptor interactions antagonize 1,25-dihydroxyvitamin D transcriptional activity and enhance stat1-mediated transcription. Mol. Cell. Biol. (United States). April 2002, 22 (8): 2777–87. ISSN 0270-7306. PMC 133712 . PMID 11909970. doi:10.1128/MCB.22.8.2777-2787.2002.  引文使用过时参数coauthors (帮助) Horvath, C M; Stark G R, Kerr I M, Darnell J E. Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex. Mol. Cell. Biol. (United States). Dec 1996, 16 (12): 6957–64. ISSN 0270-7306. PMC 231699 . PMID 8943351.  引文使用过时参数coauthors (帮助) Usacheva, Anna; Tian Xinyong, Sandoval Raudel, Salvi Debra, Levy David, Colamonici Oscar R. The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex. J. Immunol. (United States). September 2003, 171 (6): 2989–94. ISSN 0022-1767. PMID 12960323.  引文使用过时参数coauthors (帮助) Cebulla CM, Miller DM, Sedmak DD. Viral inhibition of interferon signal transduction. Intervirology. 2000, 42 (5–6): 325–30. PMID 10702714. doi:10.1159/000053968.  Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene. 2002, 285 (1–2): 1–24. PMID 12039028. doi:10.1016/S0378-1119(02)00398-0.  Joseph AM, Kumar M, Mitra D. Nef: "necessary and enforcing factor" in HIV infection. Curr. HIV Res. 2005, 3 (1): 87–94. PMID 15638726. doi:10.2174/1570162052773013.  FactorBook STAT1