CRADD

含有死亡结构域的蛋白质CRADD（英语：Death domain-containing protein CRADD）是人类中由CRADD基因编码的蛋白质。 该基因编码的蛋白质是含有死亡结构域（CARD/DD）的蛋白质，已被证明可诱导细胞凋亡。通过其CARD结构域（英语：CARD (domain)），该蛋白与胱天蛋白酶2/ICH1相互作用，从而将胱天蛋白酶2/ICH1募集到细胞死亡信号转导复合物中，该复合物包括肿瘤坏死因子受体1（英语：Tumor necrosis factor receptor 1）（TNFR1A）、RIPK1（英语：RIPK1）/RIP激酶和许多其他含有CARD结构域的蛋白。 CRADD已被证明与RIPK1（英语：RIPK1）和胱天蛋白酶2相互作用。 與CRADD相關的疾病；在維基數據上查看/編輯參考.  GRCh38: Ensembl release 89: ENSG00000169372 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000045867 - Ensembl, May 2017 Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Duan H, Dixit VM. RAIDD is a new 'death' adaptor molecule (PDF). Nature. January 1997, 385 (6611): 86–9. Bibcode:1997Natur.385...86D. PMID 8985253. 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