芳香化酶

芳香化酶、芳香酶（EC 1.14.14.14、英語：Aromatase），也稱為雌激素合成酶（英語：estrogen synthetase）或雌激素合酶（英語：estrogen synthase），是一種單加氧酶，負責雌激素生物合成的關鍵步驟。由人體基因CYP19A1編碼，是CYP450酶蛋白質超家族成員，可催化類固醇生成涉及的許多反應。催化涉及甾体激素合成步骤中从雄激素到雌激素的芳香化（英语：Aromatization）反应。芳香化酶在许多人体组织中出现，如生殖腺（颗粒细胞（英语：granulosa cell））、脑、脂肪組織、胎盤、血管、皮膚和骨骼，对青春期的第二性征发育有重要作用。 雄烯二酮 + 3O2 + 3NADPH + 3H+ ⇌ {\displaystyle \rightleftharpoons } 雌酮 + Formate + 4H2O + 3NADP+ 睾酮 + 3O2 + 3NADPH + 3H+ ⇌ {\displaystyle \rightleftharpoons } 雌二醇 + Formate + 4H2O + 3NADP+ 與芳香酶相關的疾病；在維基數據上查看/編輯參考.  對芳香酶起作用的藥物；在維基數據上查看/編輯參考.  GRCh38: Ensembl release 89: ENSG00000137869 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000032274 - Ensembl, May 2017 Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Vaz AD. 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