CYP1A2

细胞色素P450 1A2（英語：Cytochrome P450 1A2） （缩写为CYP1A2），是细胞色素P450混合功能氧化酶家族的一员，参与体内异生物质的代谢。CYP1A2酶由人类CYP1A2基因编码。 Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics. January 2004, 14 (1): 1–18. PMID 15128046. doi:10.1097/00008571-200401000-00001.  Jaiswal AK, Nebert DW, McBride OW, Gonzalez FJ. Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15. J. Exp. Pathol. 1987, 3 (1): 1–17. PMID 3681487.  Meijerman I, Beijnen J, Schellens J. Herb-drug interactions in oncology: focus on mechanisms of induction. Oncologist. 2006, 11 (7): 742–52. PMID 16880233. doi:10.1634/theoncologist.11-7-742.  Smith G, Stubbins MJ, Harries LW, Wolf CR. Molecular genetics of the human cytochrome P450 monooxygenase superfamily.. Xenobiotica. 1999, 28 (12): 1129–65. PMID 9890157. doi:10.1080/004982598238868.  Landi MT, Sinha R, Lang NP, Kadlubar FF. Human cytochrome P4501A2.. IARC Sci. Publ. 1999, (148): 173–95. PMID 10493258.  Ikeya K, Jaiswal AK, Owens RA; et al. Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression.. Mol. Endocrinol. 1990, 3 (9): 1399–408. PMID 2575218. doi:10.1210/mend-3-9-1399.  Butler MA, Iwasaki M, Guengerich FP, Kadlubar FF. Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.. Proc. Natl. Acad. Sci. U.S.A. 1989, 86 (20): 7696–700. PMC 298137 . PMID 2813353. doi:10.1073/pnas.86.20.7696.  Quattrochi LC, Okino ST, Pendurthi UR, Tukey RH. Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6.. DNA. 1986, 4 (5): 395–400. PMID 3000715. doi:10.1089/dna.1985.4.395.  Quattrochi LC, Pendurthi UR, Okino ST; et al. Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA.. Proc. Natl. Acad. Sci. U.S.A. 1986, 83 (18): 6731–5. PMC 386583 . PMID 3462722. doi:10.1073/pnas.83.18.6731.  Wrighton SA, Campanile C, Thomas PE; et al. Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat.. Mol. Pharmacol. 1986, 29 (4): 405–10. PMID 3517618.  Jaiswal AK, Nebert DW, Gonzalez FJ. Human P3(450): cDNA and complete amino acid sequence.. Nucleic Acids Res. 1986, 14 (16): 6773–4. PMC 311685 . PMID 3755823. doi:10.1093/nar/14.16.6773.  Eugster HP, Probst M, Würgler FE, Sengstag C. Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae.. Drug Metab. Dispos. 1993, 21 (1): 43–9. PMID 8095225.  Schweikl H, Taylor JA, Kitareewan S; et al. Expression of CYP1A1 and CYP1A2 genes in human liver.. Pharmacogenetics. 1994, 3 (5): 239–49. PMID 8287062. doi:10.1097/00008571-199310000-00003.  Yamazaki H, Inoue K, Mimura M; et al. 7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes.. Biochem. Pharmacol. 1996, 51 (3): 313–9. PMID 8573198. doi:10.1016/0006-2952(95)02178-7.  Hakkola J, Raunio H, Purkunen R; et al. Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy.. Biochem. Pharmacol. 1996, 52 (2): 379–83. PMID 8694864. doi:10.1016/0006-2952(96)00216-X.  Guengerich FP, Johnson WW. Kinetics of ferric cytochrome P450 reduction by NADPH-cytochrome P450 reductase: rapid reduction in the absence of substrate and variations among cytochrome P450 systems.. Biochemistry. 1998, 36 (48): 14741–50. PMID 9398194. doi:10.1021/bi9719399.  Wacke R, Kirchner A, Prall F; et al. Up-regulation of cytochrome P450 1A2, 2C9, and 2E1 in chronic pancreatitis.. Pancreas. 1998, 16 (4): 521–8. PMID 9598815. doi:10.1097/00006676-199805000-00011.  Macé K, Bowman ED, Vautravers P; et al. Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues.. Eur. J. Cancer. 1998, 34 (6): 914–20. PMID 9797707. doi:10.1016/S0959-8049(98)00034-3.  Huang JD, Guo WC, Lai MD; et al. Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese.. Drug Metab. Dispos. 1999, 27 (1): 98–101. PMID 9884316.  Tatemichi M, Nomura S, Ogura T; et al. Mutagenic activation of environmental carcinogens by microsomes of gastric mucosa with intestinal metaplasia.. Cancer Res. 1999, 59 (16): 3893–8. PMID 10463577.