肌球蛋白轻链激酶

肌球蛋白轻链激酶（英語：Myosin light-chain kinase，MYLK 或 MLCK）是一类丝氨酸/苏氨酸特异性蛋白激酶，通过磷酸化来调节II型肌球蛋白的轻链。 现存四种MLCK亚型主要分布于不同肌细胞： MYLK – 平滑肌 MYLK2 – 骨骼肌 MYLK3 – 心肌 MYLK4 – 未知 蛋白激酶A RCSB Protein Data Bank - Structure Summary for 3KF9 - Crystal structure of the SdCen/skMLCK complex. （原始内容存档于2017-06-30）.  RCSB Protein Data Bank - Structure Summary for 2X4F - The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156.. （原始内容存档于2017-06-30）.  Gao Y, Ye LH, Kishi H, Okagaki T, Samizo K, Nakamura A, Kohama K. Myosin light chain kinase as a multifunctional regulatory protein of smooth muscle contraction. IUBMB Life. June 2001, 51 (6): 337–44. PMID 11758800. doi:10.1080/152165401753366087.  Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science. December 2002, 298 (5600): 1912–34. PMID 12471243. doi:10.1126/science.1075762.  Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.  引文格式1维护：显式使用等标签 (link) Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.  引文格式1维护：显式使用等标签 (link) Clayburgh DR, Rosen S, Witkowski ED; et al. A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability.. J. Biol. Chem. 2005, 279 (53): 55506–13. PMC 1237105 . PMID 15507455. doi:10.1074/jbc.M408822200.  引文格式1维护：显式使用等标签 (link) Wang F, Graham WV, Wang Y; et al. Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression.. Am. J. Pathol. 2005, 166 (2): 409–19. PMC 1237049 . PMID 15681825. doi:10.1016/S0002-9440(10)62264-X.  引文格式1维护：显式使用等标签 (link) Russo JM, Florian P, Shen L; et al. Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure.. Gastroenterology. 2005, 128 (4): 987–1001. PMC 1237051 . PMID 15825080. doi:10.1053/j.gastro.2005.01.004.  引文格式1维护：显式使用等标签 (link) Shimizu S, Yoshida T, Wakamori M; et al. Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells.. J. Physiol. (Lond.). 2006, 570 (Pt 2): 219–35. PMC 1464317 . PMID 16284075. doi:10.1113/jphysiol.2005.097998.  引文格式1维护：显式使用等标签 (link) Kim MT, Kim BJ, Lee JH; et al. Involvement of calmodulin and myosin light chain kinase in activation of mTRPC5 expressed in HEK cells.. Am. J. Physiol., Cell Physiol. 2006, 290 (4): C1031–40. PMID 16306123. doi:10.1152/ajpcell.00602.2004.  引文格式1维护：显式使用等标签 (link) Kimura K, Wakamatsu A, Suzuki Y; et al. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.. Genome Res. 2006, 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.  引文格式1维护：显式使用等标签 (link) Connell LE, Helfman DM. Myosin light chain kinase plays a role in the regulation of epithelial cell survival.. J. Cell. Sci. 2007, 119 (Pt 11): 2269–81. PMID 16723733. doi:10.1242/jcs.02926.  Seguchi O, Takashima S, Yamazaki S; et al. A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart.. J. Clin. Invest. 2007, 117 (10): 2812–24. PMC 1978424 . PMID 17885681. doi:10.1172/JCI30804.  引文格式1维护：显式使用等标签 (link) 醫學主題詞表（MeSH）：MYLK+protein,+human 醫學主題詞表（MeSH）：Myosin-Light-Chain+Kinase 肌球蛋白轻链激酶引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。