5-HT2B受體

5-羥色胺受體2B或血清素受體2B (英語:5-Hydroxytryptamine receptor 2B (5-HT2B)或serotonin receptor 2B) 是在人類中由HTR2B基因編碼的蛋白質。 5-HT2B是5-HT2受體家族中的成員。 5-羟色胺受体 對5-HT2B受體起作用的藥物；在維基數據上查看/編輯參考.  GRCh38: Ensembl release 89: ENSG00000135914 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000026228 - Ensembl, May 2017 Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Entrez Gene: HTR2B 5-hydroxytryptamine (serotonin) receptor 2B. （原始内容存档于2019-09-18）.  Schmuck K, Ullmer C, Engels P, Lübbert H. Cloning and functional characterization of the human 5-HT2B serotonin receptor. FEBS Letters. Mar 1994, 342 (1): 85–90 [2017-01-24]. PMID 8143856. doi:10.1016/0014-5793(94)80590-3. （原始内容存档于2019-02-15）.  Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN. Multiplicity of mechanisms of serotonin receptor signal transduction. Pharmacology & Therapeutics. 2002, 92 (2-3): 179–212. PMID 11916537. doi:10.1016/S0163-7258(01)00169-3.  Bonhaus DW, Bach C, DeSouza A, Salazar FH, Matsuoka BD, Zuppan P, Chan HW, Eglen RM. The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors. British Journal of Pharmacology. Jun 1995, 115 (4): 622–8. PMC 1908489 . PMID 7582481. doi:10.1111/j.1476-5381.1995.tb14977.x.  Choi DS, Birraux G, Launay JM, Maroteaux L. The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors. FEBS Letters. Oct 1994, 352 (3): 393–9. PMID 7926008. doi:10.1016/0014-5793(94)00968-6.  Kursar JD, Nelson DL, Wainscott DB, Baez M. Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor. Molecular Pharmacology. Aug 1994, 46 (2): 227–34. PMID 8078486.  Schmuck K, Ullmer C, Engels P, Lübbert H. Cloning and functional characterization of the human 5-HT2B serotonin receptor. FEBS Letters. Mar 1994, 342 (1): 85–90. PMID 8143856. doi:10.1016/0014-5793(94)80590-3.  Launay JM, Birraux G, Bondoux D, Callebert J, Choi DS, Loric S, Maroteaux L. Ras involvement in signal transduction by the serotonin 5-HT2B receptor. The Journal of Biological Chemistry. Feb 1996, 271 (6): 3141–7. PMID 8621713. doi:10.1074/jbc.271.6.3141.  Le Coniat M, Choi DS, Maroteaux L, Launay JM, Berger R. The 5-HT2B receptor gene maps to 2q36.3-2q37.1. Genomics. Feb 1996, 32 (1): 172–3. PMID 8786115. doi:10.1006/geno.1996.0101.  Kim SJ, Veenstra-VanderWeele J, Hanna GL, Gonen D, Leventhal BL, Cook EH. Mutation screening of human 5-HT(2B)receptor gene in early-onset obsessive-compulsive disorder. Molecular and Cellular Probes. Feb 2000, 14 (1): 47–52. PMID 10722792. doi:10.1006/mcpr.1999.0281.  Manivet P, Mouillet-Richard S, Callebert J, Nebigil CG, Maroteaux L, Hosoda S, Kellermann O, Launay JM. PDZ-dependent activation of nitric-oxide synthases by the serotonin 2B receptor. The Journal of Biological Chemistry. Mar 2000, 275 (13): 9324–31. PMID 10734074. doi:10.1074/jbc.275.13.9324.  Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C. Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1. The Journal of Biological Chemistry. Apr 2001, 276 (16): 12974–82. PMID 11150294. doi:10.1074/jbc.M008089200.  Manivet P, Schneider B, Smith JC, Choi DS, Maroteaux L, Kellermann O, Launay JM. The serotonin binding site of human and murine 5-HT2B receptors: molecular modeling and site-directed mutagenesis. The Journal of Biological Chemistry. May 2002, 277 (19): 17170–8. PMID 11859080. doi:10.1074/jbc.M200195200.  Borman RA, Tilford NS, Harmer DW, Day N, Ellis ES, Sheldrick RL, Carey J, Coleman RA, Baxter GS. 5-HT(2B) receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro. British Journal of Pharmacology. Mar 2002, 135 (5): 1144–51. PMC 1573235 . PMID 11877320. doi:10.1038/sj.bjp.0704571.  Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene. May 2003, 22 (21): 3307–18. PMID 12761501. doi:10.1038/sj.onc.1206406.  Slominski A, Pisarchik A, Zbytek B, Tobin DJ, Kauser S, Wortsman J. Functional activity of serotoninergic and melatoninergic systems expressed in the skin. Journal of Cellular Physiology. Jul 2003, 196 (1): 144–53. PMID 12767050. doi:10.1002/jcp.10287.  Lin Z, Walther D, Yu XY, Drgon T, Uhl GR. The human serotonin receptor 2B: coding region polymorphisms and association with vulnerability to illegal drug abuse. Pharmacogenetics. Dec 2004, 14 (12): 805–11. PMID 15608559. doi:10.1097/00008571-200412000-00003.  5-HT2B. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. （原始内容存档于2017-02-02）.  Human HTR2B genome location and HTR2B gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）. 5-HT2B受體引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。 #invoke:navbox