UBTF

核仁转录因子1（Nucleolar transcription factor 1）又叫上游结合转录因子（Upstream binding transcription factor，缩写UBTF）或上游结合因子1（Upstream binding factor 1，缩写UBF1）是一种由人类基因UBTF 所编码的蛋白质。 UBTF是18S、5.8S和28S的核糖体RNA的转录所必须的转录因子，和SL1因子（一个四聚体，包括一个TATA结合蛋白和3个转录辅助因子TAF1（英语：TAF1））共同起作用。在人体中存在94和97kD的两种UBF多肽链。UBF是一种核仁磷酸化蛋白（nucleolar phosphoprotein），同时具有DNA结合结构域和反式激活结构域，通过HMG盒结合到人rRNA启动子的核心与上游部位。 UBTF已知能与酪蛋白激酶2α亚基（英语：Casein kinase 2, alpha 1）、TAF1C、视网膜母细胞瘤蛋白和TAF1进行交互作用。 Matera AG, Wu W, Imai H, O'Keefe CL, Chan EK. Molecular cloning of the RNA polymerase I transcription factor hUBF/NOR-90 (UBTF) gene and localization to 17q21.3 by fluorescence in situ hybridization and radiation hybrid mapping. Genomics. May 1997, 41 (1): 135–8. PMID 9126496. doi:10.1006/geno.1997.4647.  Entrez Gene: UBTF upstream binding transcription factor, RNA polymerase I.  Voit, R; Kuhn A, Sander E E, Grummt I. Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF. Nucleic Acids Res. 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