CDKN2BAS

CDKN2B-AS亦被称为ANRIL（INK4基因座中反义非编码RNA，英語：antisense non-coding RNA in the INK4 locus）是一条由19个外显子组成的长链非编码RNA，在基因组中横跨12.63万个碱基对，转录产物被剪接为长3834个碱基的RNA。该长链位于p15CDKN2B-p16CDKN2A-p14ARF基因座中且与蛋白编码基因呈反义方向转录。一些位于CDKN2B-AS的單核苷酸多態性位点（SNPs）改变其表达量，并与冠狀動脈性心臟病、糖尿病及多种癌症在内的许多疾病呈关联性。该条长链与多梳抑制复合物1中的克罗莫框7（CBX7）及多梳抑制复合物2中的SUZ12相结合，并通过与这两种多梳蛋白相互作用引起其它基因转录沉默。 长链非编码RNA Cunnington MS, Santibanez Koref M, Mayosi BM, Burn J, Keavney B. Gibson, Greg , 编. Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression. PLoS Genet. 2010, 6 (4): e1000899. PMC 2851566 . PMID 20386740. doi:10.1371/journal.pgen.1000899.  Yap KL, Li S, Muñoz-Cabello AM; et al. Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol. Cell. June 2010, 38 (5): 662–74. PMC 2886305 . PMID 20541999. doi:10.1016/j.molcel.2010.03.021.  引文格式1维护：显式使用等标签 (link) Kotake Y, Nakagawa T, Kitagawa K; et al. 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PMID 19214202. doi:10.1371/journal.pgen.1000378.  引文格式1维护：显式使用等标签 (link) CDKN2B antisense RNA 1 intronic conserved region的Rfam页面