芳基硫酸酯酶A

芳基硫酸酯酶A(Arylsulfatase A、ARSA、酰基硫酸酯酶A、腦苷硫酸酯酶/cerebroside-sulfatase、芳香基硫酸酯酶A)屬於酶之一種，它可以分解腦硫脂(sulfatide)，即分解"腦苷3硫酸"(cerebroside 3-sulfate)為脑苷脂及硫酸鹽。在人類中，芳基硫酸酯酶A由ARSA基因編碼。 ARSA缺乏症與異染性腦白質退化症(MLD)有關，屬常染色体隱性遺傳疾病。 芳基硫酸酯酶A被磷酸鹽所抑制，從而與活性位點"3-甲酰甘氨酸"(3-formylglycine/3-oxoalanine)形成一個共價鍵。 芳基硫酸酯酶B(Arylsulfatase B) 類固醇硫酸酯酶(Steroid sulfatase) 固醇硫酸酯酶(Steryl-sulfatase) 芳基硫酸酯酶E(Arylsulfatase E) Stein C, Gieselmann V, Kreysing J, Schmidt B, Pohlmann R, Waheed A, Meyer HE, O'Brien JS, von Figura K. Cloning and expression of human arylsulfatase A. J. Biol. Chem. January 1989, 264 (2): 1252–9. PMID 2562955.  Matzner U, Herbst E, Hedayati KK, Lüllmann-Rauch R, Wessig C, Schröder S, Eistrup C, Möller C, Fogh J, Gieselmann V. Enzyme replacement improves nervous system pathology and function in a mouse model for metachromatic leukodystrophy. Hum. Mol. Genet. May 2005, 14 (9): 1139–52. PMID 15772092. doi:10.1093/hmg/ddi126.  Sevin C, Aubourg P, Cartier N. 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PMID 7815433. doi:10.1136/jmg.31.9.667.  GeneReviews/NCBI/NIH/UW entry on Arylsulfatase A Deficiency - Metachromatic Leukodystrophy （页面存档备份，存于互联网档案馆） OMIM entries on ARSA Deficiency 醫學主題詞表（MeSH）：Arylsulfatase+A