EPAS1

内皮PAS结构域包含蛋白-1（英語：Endothelial PAS domain-containing protein 1，缩写EPAS1，也被称为缺氧诱导因子-2α亚基，英語：Hypoxia-inducible factor-2alpha，缩写HIF-2α）是一种由人类基因 EPAS1 所编码的蛋白质。 EPAS1所表达的蛋白是一个转录因子的组成部分，该转录因子介导一些受氧气调控基因的表达，特别是低氧（缺氧）环境下。该蛋白包含一个碱性螺旋-环-螺旋蛋白二聚化结构域，此结构域也常见于其它氧应激相关信号通路蛋白。EPAS1涉及胚胎心脏（英语：embryonic heart）的发育，并在脐带的血管壁内皮细胞中表达。EPAS1维持儿茶酚胺类物质在胚胎早期发育中的稳定，以防止心臟衰竭。儿茶酚胺类物质包括肾上腺素和去甲肾上腺素，其稳定对胎儿与成人的心脏的健康有着重要作用。 EPAS1能与芳香烃受体核转位子（英语：Aryl hydrocarbon receptor nuclear translocator）和ARNTL发生交互作用。 人類的高海拔適應（英语：High-altitude adaptation in humans） 丹尼索瓦人 與EPAS1相關的疾病；在維基數據上查看/編輯參考.  GRCh38: Ensembl release 89: ENSG00000116016 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000024140 - Ensembl, May 2017 Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Tian H, McKnight SL, Russell DW. 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A "double adaptor" method for improved shotgun library construction.. Anal. Biochem. 1996, 236 (1): 107–13. PMID 8619474. doi:10.1006/abio.1996.0138.  Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA. Large-scale concatenation cDNA sequencing.. Genome Res. 1997, 7 (4): 353–8. PMC 139146 . PMID 9110174. doi:10.1101/gr.7.4.353.  Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, Fujii-Kuriyama Y. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development.. Proc. Natl. Acad. Sci. U.S.A. 1997, 94 (9): 4273–8. PMC 20712 . PMID 9113979. doi:10.1073/pnas.94.9.4273.  Hogenesch JB, Gu YZ, Jain S, Bradfield CA. The basic helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors.. Proc. Natl. Acad. Sci. U.S.A. 1998, 95 (10): 5474–9. PMC 20401 . PMID 9576906. doi:10.1073/pnas.95.10.5474.  Takahata S, Sogawa K, Kobayashi A, Ema M, Mimura J, Ozaki N, Fujii-Kuriyama Y. Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock.. Biochem. Biophys. Res. Commun. 1998, 248 (3): 789–94. PMID 9704006. doi:10.1006/bbrc.1998.9012.  Ema M, Hirota K, Mimura J, Abe H, Yodoi J, Sogawa K, Poellinger L, Fujii-Kuriyama Y. Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.. EMBO J. 1999, 18 (7): 1905–14. PMC 1171276 . PMID 10202154. doi:10.1093/emboj/18.7.1905.  Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.. J. Biol. Chem. 2000, 275 (33): 25733–41. PMID 10823831. doi:10.1074/jbc.M002740200.  Maemura K, de la Monte SM, Chin MT, Layne MD, Hsieh CM, Yet SF, Perrella MA, Lee ME. CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression.. J. Biol. Chem. 2001, 275 (47): 36847–51. PMID 11018023. doi:10.1074/jbc.C000629200.  Luo JC, Shibuya M. A variant of nuclear localization signal of bipartite-type is required for the nuclear translocation of hypoxia inducible factors (1alpha, 2alpha and 3alpha).. Oncogene. 2001, 20 (12): 1435–44. PMID 11313887. doi:10.1038/sj.onc.1204228.  Woods SL, Whitelaw ML. Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors.. J. Biol. Chem. 2002, 277 (12): 10236–43. PMID 11782478. doi:10.1074/jbc.M110752200.  Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML. Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch.. Science. 2002, 295 (5556): 858–61. PMID 11823643. doi:10.1126/science.1068592.  Mole DR, Pugh CW, Ratcliffe PJ, Maxwell PH. Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.. Adv. Enzyme Regul. 2002, 42: 333–47. PMID 12123724. doi:10.1016/S0065-2571(01)00037-1.  Sivridis E, Giatromanolaki A, Gatter KC, Harris AL, Koukourakis MI. Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma.. Cancer. 2002, 95 (5): 1055–63. PMID 12209691. doi:10.1002/cncr.10774.  Elvert G, Kappel A, Heidenreich R, Englmeier U, Lanz S, Acker T, Rauter M, Plate K, Sieweke M, Breier G, Flamme I. Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1).. J. Biol. Chem. 2003, 278 (9): 7520–30. PMID 12464608. doi:10.1074/jbc.M211298200.  Sang N, Stiehl DP, Bohensky J, Leshchinsky I, Srinivas V, Caro J. MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300.. J. Biol. Chem. 2003, 278 (16): 14013–9. PMID 12588875. doi:10.1074/jbc.M209702200.  醫學主題詞表（MeSH）：EPAS1+protein,+human