CEBPD

CCAAT/增强子结合蛋白δ，简称C/EBP-δ或CEBPD，是一种在人类中由CEBPD基因编码的蛋白质。 由这种无内含子基因编码的蛋白质是一种bZIP转录因子，它可以作为同源二聚体与某些DNA调节区结合。它还可以与相关蛋白C/EBP-α形成异二聚体。编码的蛋白质在调节参与免疫和炎症反应的基因中很重要，并且可能参与调节与巨噬细胞活化和/或分化相关的基因。 CEBPD参与细胞凋亡和细胞增殖的调节。它可能充当肿瘤抑制因子。 一项针对小鼠的研究表明，CEBPD在慢性阻塞性肾病进展过程中可防止肾小管损伤和肾小管间质纤维化的发展。 CEBPD基因的功能可以通过基于独立验证的siRNA敲低来有效检查。 CEBPD已被证明能与SMAD3相互作用。 CCAAT增强子结合蛋白 GRCh38: Ensembl release 89: ENSG00000221869 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000071637 - Ensembl, May 2017 Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Cao Z, Umek RM, McKnight SL. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes & Development. Sep 1991, 5 (9): 1538–52. PMID 1840554. doi:10.1101/gad.5.9.1538 .  Williams SC, Cantwell CA, Johnson PF. 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PMID 8946919. doi:10.1101/gad.10.21.2794 .  Xia C, Cheshire JK, Patel H, Woo P. Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes. The International Journal of Biochemistry & Cell Biology. Dec 1997, 29 (12): 1525–39. PMID 9570146. doi:10.1016/S1357-2725(97)00083-6.  Zhu Y, Saunders MA, Yeh H, Deng WG, Wu KK. Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins. The Journal of Biological Chemistry. Mar 2002, 277 (9): 6923–8. PMID 11741938. doi:10.1074/jbc.M108075200 .  Angeloni D, Lee JD, Johnson BE, Teh BT, Dean M, Lerman MI, Sterneck E. C306A single nucleotide polymorphism in the human CEBPD gene that maps at 8p11.1-p11.2. Molecular and Cellular Probes. Dec 2001, 15 (6): 395–7. PMID 11851384. S2CID 8215328. doi:10.1006/mcpr.2001.0377. hdl:11382/3170 .  Gao H, Parkin S, Johnson PF, Schwartz RC. C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters. The Journal of Biological Chemistry. Oct 2002, 277 (41): 38827–37. PMID 12177065. doi:10.1074/jbc.M206224200 .  Dearth LR, DeWille J. Posttranscriptional and posttranslational regulation of C/EBP delta in G0 growth-arrested mammary epithelial cells. The Journal of Biological Chemistry. Mar 2003, 278 (13): 11246–55. PMID 12554732. doi:10.1074/jbc.M207930200 .  Milde-Langosch K, Löning T, Bamberger AM. Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins. Breast Cancer Research and Treatment. May 2003, 79 (2): 175–85. PMID 12825852. S2CID 45020949. doi:10.1023/A:1023929504884.  Kovács KA, Steinmann M, Magistretti PJ, Halfon O, Cardinaux JR. CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation. The Journal of Biological Chemistry. Sep 2003, 278 (38): 36959–65. PMID 12857754. doi:10.1074/jbc.M303147200 .  Chen YW, Hubal MJ, Hoffman EP, Thompson PD, Clarkson PM. Molecular responses of human muscle to eccentric exercise. Journal of Applied Physiology. Dec 2003, 95 (6): 2485–94. PMID 12937035. S2CID 9817319. doi:10.1152/japplphysiol.01161.2002.  Li R, Strohmeyer R, Liang Z, Lue LF, Rogers J. CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease. Neurobiology of Aging. Sep 2004, 25 (8): 991–9. PMID 15212823. S2CID 54232508. doi:10.1016/j.neurobiolaging.2003.10.016.  Sivko GS, Sanford DC, Dearth LD, Tang D, DeWille JW. CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control. Journal of Cellular Biochemistry. Nov 2004, 93 (4): 844–56. PMID 15389878. S2CID 31572695. doi:10.1002/jcb.20224.  Human CEBPD genome location and CEBPD gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）. 醫學主題詞表（MeSH）：CEBPD+protein,+human