ADCY7

腺苷酰环化酶7（英語：Adenylyl cyclase type 7）是人类ADCY7基因编码的一个酶。 这个基因编码与膜结合催化从三磷酸腺苷形成环腺苷酸的腺苷酰环化酶，此过程被鈣質抑制。这个基因的产物是腺苷酰环化酶4类/鸟苷酰环化酶家族的一个成员，特点是有个12跨膜结构域。 GRCh38: Ensembl release 89: ENSG00000121281 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000031659 - Ensembl, May 2017 Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Hellevuo K, Berry R, Sikela JM, Tabakoff B. Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16. Hum Genet. Mar 1995, 95 (2): 197–200. PMID 7860067. S2CID 35555146. doi:10.1007/bf00209401.  Entrez Gene: ADCY7 adenylate cyclase 7.  Nomura N, Miyajima N, Sazuka T, et al. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. DNA Res. 1995, 1 (1): 27–35. PMID 7584026. doi:10.1093/dnares/1.1.27 .  Nomura N, Miyajima N, Sazuka T, et al. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). DNA Res. 1995, 1 (1): 47–56. PMID 7584028. doi:10.1093/dnares/1.1.47 .  Hellevuo K, Welborn R, Menninger JA, Tabakoff B. Human adenylyl cyclase type 7 contains polymorphic repeats in the 3' untranslated region: investigations of association with alcoholism. Am. J. Med. Genet. 1997, 74 (1): 95–8. PMID 9034014. doi:10.1002/(SICI)1096-8628(19970221)74:1<95::AID-AJMG19>3.0.CO;2-M.  Barcova M, Speth C, Kacani L, et al. Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1. Pflügers Arch. 1999, 437 (4): 538–46. PMID 10089566. S2CID 7620262. doi:10.1007/s004240050815.  Speth C, Joebstl B, Barcova M, Dierich MP. HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones. AIDS. 2000, 14 (6): 629–36. PMID 10807185. S2CID 22105709. doi:10.1097/00002030-200004140-00001.  Patke CL, Shearer WT. gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression. J. Allergy Clin. Immunol. 2000, 105 (5): 975–82. PMID 10808179. doi:10.1067/mai.2000.105315.  Patrizio M, Colucci M, Levi G. Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures. J. Neurochem. 2001, 77 (2): 399–407. PMID 11299302. S2CID 24053412. doi:10.1046/j.1471-4159.2001.00249.x .  Yan SZ, Tang WJ. Construction of soluble adenylyl cyclase from human membrane-bound type 7 adenylyl cyclase. G Protein Pathways - Part C, Effector Mechanisms. Methods in Enzymology 345. 2002: 231–41. ISBN 978-0-12-182246-0. PMID 11665607. doi:10.1016/S0076-6879(02)45019-7.  |journal=被忽略 (帮助) Speth C, Schabetsberger T, Mohsenipour I, et al. Mechanism of Human Immunodeficiency Virus-Induced Complement Expression in Astrocytes and Neurons. J. Virol. 2002, 76 (7): 3179–88. PMC 136041 . PMID 11884542. doi:10.1128/JVI.76.7.3179-3188.2002.  Nelson EJ, Hellevuo K, Yoshimura M, Tabakoff B. Ethanol-induced phosphorylation and potentiation of the activity of type 7 adenylyl cyclase. Involvement of protein kinase C delta. J. Biol. Chem. 2003, 278 (7): 4552–60. PMID 12454008. doi:10.1074/jbc.M210386200 .  Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.  Ludwig MG, Seuwen K. Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. J. Recept. Signal Transduct. Res. 2003, 22 (1–4): 79–110. PMID 12503609. S2CID 36697419. doi:10.1081/RRS-120014589.  Ota T, Suzuki Y, Nishikawa T, et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285 .  Gerhard DS, Wagner L, Feingold EA, et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.  Beeler JA, Yan SZ, Bykov S, et al. A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase. Biochemistry. 2005, 43 (49): 15463–71. CiteSeerX 10.1.1.558.7519 . PMID 15581358. doi:10.1021/bi049088+.  Kimura K, Wakamatsu A, Suzuki Y, et al. Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes. Genome Res. 2006, 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.  Hines LM, Hoffman PL, Bhave S, et al. A sex-specific role of type VII adenylyl cyclase in depression. J. Neurosci. 2006, 26 (48): 12609–19. PMC 6674903 . PMID 17135423. doi:10.1523/JNEUROSCI.1040-06.2006 .