组氨酸脱羧酶

组氨酸脱羧酶（英語：Histidine decarboxylase，HDC）是一种以如下方式在维生素B6的帮助下催化从組氨酸生成組織胺的反应的酶： C6H9N3O2 → C5H9N3 + CO2 在人体中，组氨酸脱羧酶由HDC基因编码。 生物胺组织胺在许多生理过程中有重要的调节作用，包括神经传递、胃酸分泌、平滑肌舒张。从组氨酸到组织胺的生物合成由L-组氨酸脱羧酶催化。这个同源二聚体酶是一个依赖磷酸吡哆醛（PLP）的脱羧酶，并对其底物组氨酸有高度特异性。 Epps HM. Studies on bacterial amino-acid decarboxylases: 4. l(-)-histidine decarboxylase from Cl. welchii Type A. Biochem. J. 1945, 39 (1): 42–6. PMC 1258146 . PMID 16747851.  Riley WD, Snell EE. Histidine decarboxylase of Lactobacillus 30a. IV. The presence of covalently bound pyruvate as the prosthetic group. Biochemistry. October 1968, 7 (10): 3520–8. PMID 5681461.  Rosenthaler J, Guirard BM, Chang GW, Snell EE. Purification and properties of histidine decarboxylase from Lactobacillus 30a. Proc. Natl. Acad. Sci. U.S.A. July 1965, 54 (1): 152–8. PMC 285813 . PMID 5216347.  Entrez Gene: histidine decarboxylase. （原始内容存档于2020-03-28）.  Bruneau G, Nguyen VC, Gros F, Bernheim A, Thibault J. Preparation of a rat brain histidine decarboxylase (HDC) cDNA probe by PCR and assignment of the human HDC gene to chromosome 15. Hum. Genet. November 1992, 90 (3): 235–8. PMID 1487235.  Need AC, Keefe RS, Ge D; et al. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.. Eur. J. Hum. Genet. 2009, 17 (7): 946–57. PMID 19156168. doi:10.1038/ejhg.2008.264.  引文格式1维护：显式使用等标签 (link) Masini E, Fabbroni V, Giannini L; et al. Histamine and histidine decarboxylase up-regulation in colorectal cancer: correlation with tumor stage.. Inflamm. Res. 2005,. 54 Suppl 1: S80–1. PMID 15928846. doi:10.1007/s00011-004-0437-3.  引文格式1维护：显式使用等标签 (link) Li Z, Liu J, Tang F; et al. Expression of non-mast cell histidine decarboxylase in tumor-associated microvessels in human esophageal squamous cell carcinomas.. APMIS. 2008, 116 (12): 1034–42. PMID 19133005. doi:10.1111/j.1600-0463.2008.01048.x.  引文格式1维护：显式使用等标签 (link) Szafranski K, Schindler S, Taudien S; et al. Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.. Genome Biol. 2007, 8 (8): R154. PMID 17672918. doi:10.1186/gb-2007-8-8-r154.  引文格式1维护：显式使用等标签 (link) Ai W, Liu Y, Langlois M, Wang TC. Kruppel-like factor 4 (KLF4) represses histidine decarboxylase gene expression through an upstream Sp1 site and downstream gastrin responsive elements.. J. Biol. Chem. 2004, 279 (10): 8684–93. PMID 14670968. doi:10.1074/jbc.M308278200.  Raychowdhury R, Fleming JV, McLaughlin JT; et al. Identification and characterization of a third gastrin response element (GAS-RE3) in the human histidine decarboxylase gene promoter.. Biochem. Biophys. Res. Commun. 2002, 297 (5): 1089–95. PMID 12372397.  引文格式1维护：显式使用等标签 (link) Kimura K, Wakamatsu A, Suzuki Y; et al. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.. Genome Res. 2006, 16 (1): 55–65. PMID 16344560. doi:10.1101/gr.4039406.  引文格式1维护：显式使用等标签 (link) SkÃ¶ldberg F, Portela-Gomes GM, Grimelius L; et al. Histidine decarboxylase, a pyridoxal phosphate-dependent enzyme, is an autoantigen of gastric enterochromaffin-like cells.. J. Clin. Endocrinol. Metab. 2003, 88 (4): 1445–52. PMID 12679420.  引文格式1维护：显式使用等标签 (link) Brew O, Lakasing L, Sullivan M. Differential activity of histidine decarboxylase in normal and pre-eclamptic placentae.. Placenta: 585–7. PMID 16822545. doi:10.1016/j.placenta.2006.05.003.  Zhang F, Xiong DH, Wang W; et al. HDC gene polymorphisms are associated with age at natural menopause in Caucasian women.. Biochem. Biophys. Res. Commun. 2006, 348 (4): 1378–82. PMID 16919600. doi:10.1016/j.bbrc.2006.08.008.  引文格式1维护：显式使用等标签 (link) Tippens AS, Gruetter CA. Detection of histidine decarboxylase mRNA in human vascular smooth muscle and endothelial cells.. Inflamm. Res. 2004, 53 (6): 215–6. PMID 15167966. doi:10.1007/s00011-004-1252-6.  Siezen CL, Bont L, Hodemaekers HM; et al. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.. Pediatr. Infect. Dis. J. 2009, 28 (4): 333–5. PMID 19258923. doi:10.1097/INF.0b013e31818e2aa9.  引文格式1维护：显式使用等标签 (link) Morgan TK, Montgomery K, Mason V; et al. Upregulation of histidine decarboxylase expression in superficial cortical nephrons during pregnancy in mice and women.. Kidney Int. 2006, 70 (2): 306–14. PMID 16760908. doi:10.1038/sj.ki.5001553.  引文格式1维护：显式使用等标签 (link) Papadopoulou N, Kalogeromitros D, Staurianeas NG; et al. Corticotropin-releasing hormone receptor-1 and histidine decarboxylase expression in chronic urticaria.. J. Invest. Dermatol. 2005, 125 (5): 952–5. PMID 16297195. doi:10.1111/j.0022-202X.2005.23913.x.  引文格式1维护：显式使用等标签 (link) Janssen R, Bont L, Siezen CL; et al. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.. J. Infect. Dis. 2007, 196 (6): 826–34. PMID 17703412. doi:10.1086/520886.  引文格式1维护：显式使用等标签 (link) Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2002, 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899.  引文格式1维护：显式使用等标签 (link) Aichberger KJ, Mayerhofer M, Vales A; et al. The CML-related oncoprotein BCR/ABL induces expression of histidine decarboxylase (HDC) and the synthesis of histamine in leukemic cells.. Blood. 2006, 108 (10): 3538–47. PMID 16849647. doi:10.1182/blood-2005-12-028456.  引文格式1维护：显式使用等标签 (link) Lee JK, Kim HT, Cho SM; et al. Characterization of 458 single nucleotide polymorphisms of disease candidate genes in the Korean population.. J. Hum. Genet. 2003, 48 (5): 213–6. PMID 12768436. doi:10.1007/s10038-003-0011-9.  引文格式1维护：显式使用等标签 (link) Jeong HJ, Moon PD, Kim SJ; et al. Activation of hypoxia-inducible factor-1 regulates human histidine decarboxylase expression.. Cell. Mol. Life Sci. 2009, 66 (7): 1309–19. PMID 19266161. doi:10.1007/s00018-009-9001-1.  引文格式1维护：显式使用等标签 (link) 醫學主題詞表（MeSH）：Histidine+Decarboxylase Histamine MS Spectrum （页面存档备份，存于互联网档案馆） DrugBank EXPT01785 Histamine bound to proteins （页面存档备份，存于互联网档案馆） in the PDB