胱天蛋白酶10

胱天蛋白酶10（英语：Caspase 10）是一种在人类中由CASP10基因编码的酶。 该基因编码的蛋白质是胱天蛋白酶家族的成员。胱天蛋白酶的连续激活在细胞凋亡的执行阶段发挥着核心作用。胱天蛋白酶以无活性的酶原形式存在，在保守的天冬氨酸残基处经历蛋白水解加工，产生一大一小两个亚基，然后二聚化形成活性酶。 胱天蛋白酶9裂解并激活胱天蛋白酶3和7，而该酶本身由胱天蛋白酶8加工。该基因的突变与II型自身免疫性淋巴细胞增生综合征中出现的细胞凋亡缺陷相关。该基因有三种编码不同异构体的选择性剪接的转录变体。 胱天蛋白酶10已被证明可以与以下物质相互作用： FADD CFLAR 胱天蛋白酶8 Fas受体 RYBP TNFRSF1A TNFRSF10B 蛋白酶解图谱（英语：The Proteolysis Map） 與胱天蛋白酶10相關的疾病；在維基數據上查看/編輯參考.  對Caspase 10起作用的藥物；在維基數據上查看/編輯參考.  GRCh38: Ensembl release 89: ENSG00000003400 - Ensembl, May 2017 Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Fernandes-Alnemri T, Armstrong RC, Krebs J, Srinivasula SM, Wang L, Bullrich F, Fritz LC, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc Natl Acad Sci USA. October 1996, 93 (15): 7464–9. Bibcode:1996PNAS...93.7464F. PMC 38767 . 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