C5a受体

C5a受体（英語：C5a receptor或称补体成分5a受体1，complement component 5a receptor 1，C5AR1或CD88，Cluster of Differentiation 88）是一种与补体C5a（英语：Complement component 5a）相结合的G蛋白偶联受体。 C5a受体表达于以下细胞： 粒细胞 单核细胞 树突状细胞 肝癌细胞Hep G2以及由其衍生的肝癌细胞系 星形膠質細胞 小胶质细胞 补体成分5a（英语：Complement component 5a） GRCh38: Ensembl release 89: ENSG00000197405 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000049130 - Ensembl, May 2017 Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Gerard C, Gerard NP. C5A anaphylatoxin and its seven transmembrane-segment receptor. Annu. Rev. Immunol. 1994, 12: 775–808. PMID 8011297. doi:10.1146/annurev.iy.12.040194.004015.  Klos A, Wende E, Wareham KJ, Monk PN. International Union of Pharmacology. LXXXVII. Complement peptide C5a, C4a, and C3a receptors. Pharmacol. Rev. 2013, 65 (1): 500–43. 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CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin.. J. Immunol. 1996, 157 (4): 1729–35. PMID 8759762.  引文格式1维护：显式使用等标签 (link) Höpken UE, Lu B, Gerard NP, Gerard C. The C5a chemoattractant receptor mediates mucosal defence to infection.. Nature. 1996, 383 (6595): 86–9. PMID 8779720. doi:10.1038/383086a0.  Chen Z, Zhang X, Gonnella NC; et al. Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin.. J. Biol. Chem. 1998, 273 (17): 10411–9. PMID 9553099. doi:10.1074/jbc.273.17.10411.  引文格式1维护：显式使用等标签 (link) Floreani AA, Heires AJ, Welniak LA; et al. Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: enhancement of C5a-mediated release of IL-8 upon exposure to cigarette smoke.. J. Immunol. 1998, 160 (10): 5073–81. PMID 9590258.  引文格式1维护：显式使用等标签 (link) Ottonello L, Corcione A, Tortolina G; et al. rC5a directs the in vitro migration of human memory and naive tonsillar B lymphocytes: implications for B cell trafficking in secondary lymphoid tissues.. J. Immunol. 1999, 162 (11): 6510–7. PMID 10352266.  引文格式1维护：显式使用等标签 (link) Kohleisen B, Shumay E, Sutter G; et al. Stable expression of HIV-1 Nef induces changes in growth properties and activation state of human astrocytes.. AIDS. 2000, 13 (17): 2331–41. PMID 10597774. doi:10.1097/00002030-199912030-00004.  引文格式1维护：显式使用等标签 (link) Monk PN, Scola A-M, Madala P, Fairlie DP. Function, structure and therapeutic potential of complement C5a receptors. British Journal of Pharmacology. 2007, 152 (4): 429–48. PMC 2050825 . PMID 17603557. doi:10.1038/sj.bjp.0707332.  Anaphylatoxin Receptors: C5a. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. （原始内容存档于2014-04-07）.  醫學主題詞表（MeSH）：C5a+receptors