周期蛋白A1

周期蛋白A1（英語：Cyclin-A1，或译为周期素A1）是一个由人类基因 CCNA1 编码的蛋白质。 该基因编码的蛋白质属于高度保守的周期蛋白家族，该家族成员的显著特征是贯穿细胞周期，其蛋白质丰度周期性地急剧改变。周期蛋白作为CDK（周期蛋白依赖性激酶）的调节因子。不同的周期蛋白表现出各自独特的表达及降解特性，这有助于每个有丝分裂事件在时间上的协调性。周期蛋白A1表达于睾丸、大脑以及一些严重的白血病细胞系中，现任为其主要功能是控制减数分裂。该周期蛋白与Cdk1和Cdk2两种激酶相结合，但这两种激酶活性完全不相同，前者激酶活性表现于G2期，而后者激酶活性表现于S期，因此在细胞周期中调控了不同的功能。现发现这种周期蛋白可结合到重要的细胞周期调节物上，后者如：Rb家族蛋白、转录因子E2F1以及CDK抑制蛋白中的Kip/Cip家族。 周期蛋白A1能与E2F1、CDC20、视网膜母细胞瘤蛋白、周期蛋白依赖性激酶2（英语：Cyclin-dependent kinase 2）、GPS2（英语：GPS2 (gene)） MYBL2和GNB2L1发生相互作用。 Yang R, Morosetti R, Koeffler HP. Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. Cancer Res. March 1997, 57 (5): 913–20. PMID 9041194.  Entrez Gene: CCNA1 cyclin A1.  Yang, R; Müller C, Huynh V, Fung Y K, Yee A S, Koeffler H P. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. Mol. Cell. Biol. (UNITED STATES). March 1999, 19 (3): 2400–7. ISSN 0270-7306. PMC 84032 . 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