腎病蛋白

腎病蛋白（Nephrin）對於"腎小球濾過屏障"(renal filtration barrier)的適當運作是必需要的蛋白质。"腎小球濾過屏障"由"窗孔內皮細胞"(fenestrated endothelial cell)、腎小球基底膜(GBM)，以及"上皮細胞"(epithelial cell)之足細胞所組成。腎病蛋白是一種跨膜蛋白，它是濾過裂隙的一個結構部件。 在腎病蛋白、NPHS1、基因中的缺陷，與"芬蘭型先天性腎病綜合癥"(congenital nephrotic syndrome)有所相關聯，並且導致蛋白質大量被洩漏到尿，或蛋白尿裡。而"心血管"(cardiovascular)的發展需要腎病蛋白。 腎病蛋白已顯示出與下列蛋白之蛋白質交互作用： CASK, CD2AP, CDH3 and CTNND1, FYN, KIRREL, and NPHS2. 足蛋白 Entrez Gene: NPHS1 nephrosis 1, congenital, Finnish type (nephrin). （原始内容存档于2019-09-12）.  Wagner, N; Morrison, H; Pagnotta, S; Michiels, JF; Schwab, Y; Tryggvason, K; Schedl, A; Wagner, KD. The podocyte protein nephrin is required for cardiac vessel formation.. Human Molecular Genetics. 2011-03-29, 20 (11): 2182–94. PMID 21402589. doi:10.1093/hmg/ddr106.  Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG. Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin. Am. J. Pathol. Sep 2004, 165 (3): 923–36. 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Differential expression of nephrin in acquired human proteinuric diseases.. Am. J. Kidney Dis. 2002, 40 (5): 964–73. PMID 12407641. doi:10.1053/ajkd.2002.36328.  Langham RG; Kelly DJ; Cox AJ; et al. Proteinuria and the expression of the podocyte slit diaphragm protein, nephrin, in diabetic nephropathy: effects of angiotensin converting enzyme inhibition.. Diabetologia. 2003, 45 (11): 1572–6. PMID 12436341. doi:10.1007/s00125-002-0946-y.  Gigante M; Monno F; Roberto R; et al. Congenital nephrotic syndrome of the Finnish type in Italy: a molecular approach.. J. Nephrol. 2003, 15 (6): 696–702. PMID 12495287.  Pettersson-Fernholm K; Forsblom C; Perola M; et al. Polymorphisms in the nephrin gene and diabetic nephropathy in type 1 diabetic patients.. Kidney Int. 2003, 63 (4): 1205–10. PMID 12631336. doi:10.1046/j.1523-1755.2003.00855.x.  醫學主題詞表（MeSH）：nephrin