16BO133病毒

16BO133病毒是嚴重急性呼吸系統綜合症相關冠狀病毒（SARSr-CoV）的一個病毒株，在韓國的馬鐵菊頭蝠中發現，於2019年發表，其基因組被完整定序，是首個被完整定序的韓國SARSr-CoV病毒株，在SARSr-CoV中屬於SARS-CoV相關病毒，與其基因組序列相似度為82.8%。 16BO133病毒於2016年在韓國馬鐵菊頭蝠的口腔樣本中被發現，此病毒株的基因組長29075nt。在SARSr-CoV中，16BO133和2016年發表、自中國吉林馬鐵菊頭蝠中發現的JTMC15病毒最為接近，基因組核酸序列相似度為98.3%，與其他SARSr-CoV相較之下，這兩個病毒株因爲ORF7b末端的框移突變而喪失了ORF8。16BO133病毒和SARS-CoV的基因組核酸序列相似度則為82.8%。 過去雖有其他SARSr-CoV病毒株在韓國被發現（B15-21病毒等），但皆無完整序列定序，16BO133病毒是首個被完整定序的韓國SARSr-CoV病毒株。 截至2021年1月 (2021-01)[update]，SARS-CoV與相關病毒株的系統發生樹：   蝙蝠病毒   果子狸病毒   人類病毒 病毒主题 Kim, Yongkwan; Son, Kidong; Kim, Young-Sik; Lee, Sook-Young; Jheong, Weonhwa; Oem, Jae-Ku. Complete genome analysis of a SARS-like bat coronavirus identified in the Republic of Korea. Virus Genes. 2019-08, 55 (4). ISSN 0920-8569. PMC 7089380 . PMID 31076983. doi:10.1007/s11262-019-01668-w （英语）.  Xu L, Zhang F, Yang W, Jiang T, Lu G, He B; et al. Detection and characterization of diverse alpha- and betacoronaviruses from bats in China.. Virol Sin. 2016, 31 (1): 69–77. PMC 7090707 . PMID 26847648. doi:10.1007/s12250-016-3727-3.  Na EJ, Lee SY, Kim HJ, Oem JK. Comparative genetic analyses of Korean bat coronaviruses with SARS-CoV and the newly emerged SARS-CoV-2.. J Vet Sci. 2021, 22 (1): e12. PMC 7850784 . PMID 33522164. doi:10.4142/jvs.2021.22.e12.  Kim HK, Yoon SW, Kim DJ, Koo BS, Noh JY, Kim JH; et al. Detection of Severe Acute Respiratory Syndrome-Like, Middle East Respiratory Syndrome-Like Bat Coronaviruses and Group H Rotavirus in Faeces of Korean Bats.. Transbound Emerg Dis. 2016, 63 (4): 365–72. PMC 7169817 . PMID 27213718. doi:10.1111/tbed.12515.  Li, Wendong; Shi, Zhengli; Yu, Meng; Ren, Wuze; Smith, Craig; Epstein, Jonathan H.; Wang, Hanzhong; Crameri, Gary; Hu, Zhihong; Zhang, Huajun; Zhang, Jianhong. Bats Are Natural Reservoirs of SARS-Like Coronaviruses. Science. 2005-10-28, 310 (5748). ISSN 0036-8075. doi:10.1126/science.1118391 （英语）.  Ge, Xing-Yi; Hu, Ben; Shi, Zheng-Li. Bat Coronaviruses. Wang, Lin-Fa (编). Bats and Viruses. Hoboken, NJ: John Wiley & Sons, Inc. 2015-06-26: 127–155. ISBN 978-1-118-81882-4. doi:10.1002/9781118818824.ch5 （英语）.  He, Biao; Zhang, Yuzhen; Xu, Lin; Yang, Weihong; Yang, Fanli; Feng, Yun; Xia, Lele; Zhou, Jihua; Zhen, Weibin; Feng, Ye; Guo, Huancheng. Perlman, S. , 编. Identification of Diverse Alphacoronaviruses and Genomic Characterization of a Novel Severe Acute Respiratory Syndrome-Like Coronavirus from Bats in China. Journal of Virology. 2014-06-15, 88 (12). ISSN 0022-538X. PMC 4054348 . PMID 24719429. doi:10.1128/JVI.00631-14 （英语）.  Lau, Susanna K. P.; Feng, Yun; Chen, Honglin; Luk, Hayes K. H.; Yang, Wei-Hong; Li, Kenneth S. M.; Zhang, Yu-Zhen; Huang, Yi; Song, Zhi-Zhong; Chow, Wang-Ngai; Fan, Rachel Y. Y. Perlman, S. , 编. Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination. Journal of Virology. 2015-10-15, 89 (20). ISSN 0022-538X. PMC 4580176 . PMID 26269185. doi:10.1128/JVI.01048-15 （英语）.  Ge, Xing-Yi; Li, Jia-Lu; Yang, Xing-Lou; Chmura, Aleksei A.; Zhu, Guangjian; Epstein, Jonathan H.; Mazet, Jonna K.; Hu, Ben; Zhang, Wei; Peng, Cheng; Zhang, Yu-Ji. Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature. 2013-11, 503 (7477). Bibcode:2013Natur.503..535G. ISSN 0028-0836. PMC 5389864 . PMID 24172901. doi:10.1038/nature12711 （英语）.  Yang, Xing-Lou; Hu, Ben; Wang, Bo; Wang, Mei-Niang; Zhang, Qian; Zhang, Wei; Wu, Li-Jun; Ge, Xing-Yi; Zhang, Yun-Zhi; Daszak, Peter; Wang, Lin-Fa. Perlman, S. , 编. Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus. Journal of Virology. 2016-03-15, 90 (6). ISSN 0022-538X. PMC 4810638 . PMID 26719272. doi:10.1128/JVI.02582-15 （英语）.