视网膜母细胞瘤蛋白

视网膜母细胞瘤蛋白（英語：retinoblastoma protein，常缩写为Rb、RB或RB1）又译为成视网膜细胞瘤蛋白是一种抑癌蛋白，并在几种主要的癌症发生时失活。Rb的功能之一是通过抑制细胞周期进程直到细胞准备妥当来防止细胞过度生长。当细胞准备好要分裂时，Rb蛋白会被磷酸化为pRb而失去抑制活性，从而使细胞周期进行下去。 Rb是袋状蛋白家族的一员，其特点是有一个口袋状的结构用以结合其它蛋白。使得一些致癌变蛋白，比如高危险群人类乳突病毒所感染的细胞产生的蛋白，结合并抑制pRb，最终导致癌症。 已知Rb蛋白与下列蛋白质有相互作用关系： Abl gene Androgen receptor Apoptosis-antagonizing transcription factor ARID4A 芳香烃受体 BRCA1 BRF1 C-jun C-Raf CDK9 CUTL1 周期蛋白A1 周期蛋白D1 周期蛋白T2 DNMT1 E2F1 E2F2, E4F1 EID1 ENC1 FRK HBP1 HDAC1 HDAC3 Histone deacetylase 2 胰岛素 JARID1A LIN9 MCM7 MORF4L1 MRFAP1, MyoD NCOA6 PA2G4 过氧化物酶体增殖物活化受体γ PIK3R3 Plasminogen activator inhibitor-2 Polymerase (DNA directed), alpha 1 PRDM2 PRKRA Prohibitin 早幼粒细胞白血病蛋白 RBBP4 RBBP7 RBBP8 RBBP9 SNAPC1 SKP2 SNAPC3 SNW1 SUV39H1 TAF1 THOC1 TRAP1 TRIP11 UBTF USP4. 與视网膜母细胞瘤蛋白相關的疾病；在維基數據上查看/編輯參考.  GRCh38: Ensembl release 89: ENSG00000139687 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000022105 - Ensembl, May 2017 Human PubMed Reference:. 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PMID 16816134.  醫學主題詞表（MeSH）：RB1+protein,+human 醫學主題詞表（MeSH）：Retinoblastoma+genes GeneReviews/NIH/NCBI/UW entry on Retinoblastoma （页面存档备份，存于互联网档案馆） Retinoblastoma Genetics （页面存档备份，存于互联网档案馆） Drosophila Retinoblastoma-family protein - The Interactive Fly （页面存档备份，存于互联网档案馆） Drosophila Retinoblastoma-family protein 2 - The Interactive Fly （页面存档备份，存于互联网档案馆） Evolutionary Homologs Retinoblastoma-family proteins - The Interactive Fly （页面存档备份，存于互联网档案馆） There is a diagram of the pRb-E2F interactions here[永久失效連結]. p53：参与pRb的DNA修复功能 轉錄輔助調節因子(transcription coregulator) 视网膜母细胞瘤