免疫相关GTP酶家族M蛋白

免疫相关GTP酶家族M蛋白（英語：Immunity-related GTPase family M protein，IRGM），亦称为干扰素诱导蛋白1（英語：interferon-inducible protein 1，IFI1），是人体IRGM基因表达的一种酶。 IRGM是干扰素诱导GTP酶家族中的分子量为47kDa的免疫相关鸟苷三磷酸酶（英语：IRGs）（IRGs）成员之一。该基因编码的蛋白可能通过调控对胞内病原体的自噬形成而在先天免疫反应中发挥重要作用。 影响该基因表达的多态性位点与克隆氏症和结核病的易感性有关。 與免疫相关GTP酶家族M蛋白相關的疾病；在維基數據上查看/編輯參考.  GRCh38: Ensembl release 89: ENSG00000237693 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000069874 - Ensembl, May 2017 Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Entrez Gene: immunity-related GTPase family. （原始内容存档于2009-08-09）.  Prescott, Natalie J.; Dominy, Katherine M.; Kubo, Michiaki; Lewis, Cathryn M.; Fisher, Sheila A.; Redon, Richard; Huang, Ni; Stranger, Barbara E.; Blaszczyk, Katarzyna; Hudspith, Barry; Parkes, Gareth. 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Is there a role for Crohnʼs disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas?:. European Journal of Gastroenterology & Hepatology. 2010-08, 22 (8). ISSN 0954-691X. doi:10.1097/MEG.0b013e32833775e6 （英语）.  Singh, Sudha B.; Ornatowski, Wojciech; Vergne, Isabelle; Naylor, John; Delgado, Monica; Roberts, Esteban; Ponpuak, Marisa; Master, Sharon; Pilli, Manohar; White, Eileen; Komatsu, Masaaki. Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria. Nature Cell Biology. 2010-12, 12 (12) [2022-08-28]. ISSN 1465-7392. PMC 2996476 . PMID 21102437. doi:10.1038/ncb2119. （原始内容存档于2023-02-15） （英语）.  Latiano, Anna; Palmieri, Orazio; Corritore, Giuseppe; Valvano, Maria Rosa; Bossa, Fabrizio; Cucchiara, Salvatore; Castro, Massimo; Riegler, Gabriele; De Venuto, Domenica; DʼIncà, Renata; Andriulli, Angelo. 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PMID 20886065. doi:10.1371/journal.pone.0012952 （英语）.  Wagner, Josef; Sim, Winnie H.; Ellis, Justine A.; Ong, Eng K.; Catto-Smith, Anthony G.; Cameron, Donald J. S.; Bishop, Ruth F.; Kirkwood, Carl D. Bereswill, Stefan , 编. Interaction of Crohn's Disease Susceptibility Genes in an Australian Paediatric Cohort. PLoS ONE. 2010-11-08, 5 (11). ISSN 1932-6203. PMC 2975706 . PMID 21079743. doi:10.1371/journal.pone.0015376 （英语）.  Meggyesi N, Kiss LS, Koszarska M, et al. NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients.. World J. Gastroenterol. 2010, 16 (41): 5233–40. PMC 2975094 . PMID 21049557. doi:10.3748/wjg.v16.i41.5233.  免疫相关GTP酶家族M蛋白引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。 生物学主題