类固醇生成因子1

类固醇生成因子1（英語：steroidogenic factor 1，缩写SF-1）是一种参与性別決定的转录因子，涉及生殖腺与肾上腺。这一蛋白由NR5A1基因编码，属于核受体超家族，位于9号染色体长臂段的位置33.3。SF-1最初发现于其能调节CYP450类固醇羟化酶的表达，因而得名，之后又发现了参与调控许多相关基因。 SF-1最早在肾上腺皮质的类固醇生成细胞中被鉴定出具有调控类固醇生成酶活性，此后又发现在其它类固醇生成细胞中的活性： SF1还可與下列蛋白發生相互作用： β-连环蛋白 DAX1 NRIP1 SOX9 TRERF1 與類固醇生成因子相關的疾病；在維基數據上查看/編輯參考.  GRCh38: Ensembl release 89: ENSG00000136931 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000026751 - Ensembl, May 2017 Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Reference, Genetics Home. NR5A1 gene. Genetics Home Reference. [2017-11-30]. （原始内容存档于2020-08-07） （英语）.  Parker KL, Schimmer BP. Steroidogenic factor 1: a key determinant of endocrine development and function. Endocrine Reviews. June 1997, 18 (3): 361–77. PMID 9183568. doi:10.1210/edrv.18.3.0301.  J W Clemens, D S Lala, K L Parker, J S Richards. Steroidogenic factor-1 binding and transcriptional activity of the cholesterol side-chain cleavage promoter in rat granulosa cells.. Endocrinology. 1994-03, 134 (3): 1499–1508 [2020-02-02]. ISSN 0013-7227. doi:10.1210/endo.134.3.8119192 （英语）.  R.J. Ferrier. Synthetic Carbohydrate Chemistry of the 1980s. Carbohydrate Research. 1990-07, 202: ix–xi [2020-02-02]. doi:10.1016/0008-6215(90)84066-4. （原始内容存档于2018-06-23） （英语）.  U. Wehrenberg, R. Ivell, M. Jansen, S. von Goedecke, N. Walther. Two orphan receptors binding to a common site are involved in the regulation of the oxytocin gene in the bovine ovary.. Proceedings of the National Academy of Sciences. 1994-02-15, 91 (4): 1440–1444 [2020-02-02]. ISSN 0027-8424. PMC 43175 . PMID 8108428. doi:10.1073/pnas.91.4.1440 （英语）.  K. M. Caron. Characterization of the Promoter Region of the Mouse Gene Encoding the Steroidogenic Acute Regulatory Protein. Molecular Endocrinology. 1997-02-01, 11 (2): 138–147 [2020-02-02]. ISSN 0888-8809. doi:10.1210/me.11.2.138 （英语）. [永久失效連結] Kennell JA, O'Leary EE, Gummow BM, Hammer GD, MacDougald OA. T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors. Molecular and Cellular Biology. August 2003, 23 (15): 5366–75. PMC 165725 . PMID 12861022. doi:10.1128/MCB.23.15.5366-5375.2003.  Mizusaki H, Kawabe K, Mukai T, Ariyoshi E, Kasahara M, Yoshioka H, Swain A, Morohashi K. Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by wnt4 in the female developing gonad. Molecular Endocrinology. April 2003, 17 (4): 507–19. PMID 12554773. doi:10.1210/me.2002-0362 .  Lopez D, Shea-Eaton W, Sanchez MD, McLean MP. DAX-1 represses the high-density lipoprotein receptor through interaction with positive regulators sterol regulatory element-binding protein-1a and steroidogenic factor-1. Endocrinology. December 2001, 142 (12): 5097–106. PMID 11713202. doi:10.1210/endo.142.12.8523 .  Sugawara T, Saito M, Fujimoto S. Sp1 and SF-1 interact and cooperate in the regulation of human steroidogenic acute regulatory protein gene expression. Endocrinology. August 2000, 141 (8): 2895–903. PMID 10919277. doi:10.1210/endo.141.8.7602 .  Mellgren G, Børud B, Hoang T, Yri OE, Fladeby C, Lien EA, Lund J. Characterization of receptor-interacting protein RIP140 in the regulation of SF-1 responsive target genes. Molecular and Cellular Endocrinology. May 2003, 203 (1–2): 91–103. PMID 12782406. S2CID 733221. doi:10.1016/S0303-7207(03)00097-2.  Sugawara T, Abe S, Sakuragi N, Fujimoto Y, Nomura E, Fujieda K, Saito M, Fujimoto S. RIP 140 modulates transcription of the steroidogenic acute regulatory protein gene through interactions with both SF-1 and DAX-1. Endocrinology. August 2001, 142 (8): 3570–7. PMID 11459805. doi:10.1210/endo.142.8.8309 .  De Santa Barbara P, Bonneaud N, Boizet B, Desclozeaux M, Moniot B, Sudbeck P, Scherer G, Poulat F, Berta P. Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Müllerian hormone gene. Molecular and Cellular Biology. November 1998, 18 (11): 6653–65. PMC 109250 . PMID 9774680. doi:10.1128/mcb.18.11.6653.  Gizard F, Lavallee B, DeWitte F, Teissier E, Staels B, Hum DW. The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells. The Journal of Biological Chemistry. October 2002, 277 (42): 39144–55. PMID 12101186. doi:10.1074/jbc.M205786200 .  GeneReviews/NCBI/NIH/UW entry on 46,XY Disorder of Sex Development and 46,XY Complete Gonadal Dysgenesis （页面存档备份，存于互联网档案馆） OMIM entries on 46,XY Disorder of Sex Development and 46,XY Complete Gonadal Dysgenesis 醫學主題詞表（MeSH）：steroidogenic+factor+1