妊娠相关血浆蛋白A

妊娠相关血浆蛋白A（英語：pregnancy-associated plasma protein A，或Pappalysin-1，缩写PAPP-A）是一种由人类基因 PAPPA 编码的蛋白质，PAPP-A是一种分泌蛋白酶，其主要底物是胰岛素样生长因子结合蛋白。PAPP-A也用于唐氏综合征的筛查试验。 此基因编码一种分泌的金属蛋白酶，主要用于切割胰岛素样生长因子的结合蛋白（IGFBPs）。PAPP-A的蛋白水解活性在与膠原蛋白结合后被激活，参与许多局部增生过程，比如傷口癒合和骨重塑。血浆中出现低水平的此蛋白被认为是妊娠中出现非整倍體胎兒（胎兒拥有不正常的染色体数）的生化标志物，比如在唐氏综合征的產前診斷中，低水平的PAPP-A是一个重要标志。低水平的PAPP-A也可表明胎盤存在问题，并导致不良并发症如宫内生长受限、妊娠毒血症、胎盤早期剝離、早產乃至死產。 妊娠相关血浆蛋白A已知可与主要碱性蛋白发生蛋白質交互作用。 GRCh38: Ensembl release 89: ENSG00000182752 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000028370 - Ensembl, May 2017 Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Breathnach FM, Malone FD. Screening for aneuploidy in first and second trimesters: is there an optimal paradigm?. Curr. Opin. Obstet. Gynecol. 2007, 19 (2): 176–82. 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