ID3 (基因)

ID3（分化抑制因子3，Inhibitor of Differentiation 3），正式名稱爲「inhibitor of DNA binding 3, HLH protein」（DNA結合抑制因子3，HLH（螺旋-環-螺旋）蛋白）。人ID3蛋白由ID3基因編碼。 分化抑制因子（ID）家族螺旋-環-螺旋（HLH）蛋白質缺乏基因的DNA結合結構域。它通過與其他的HLH蛋白形成異二聚體，阻止其與DNA結合，進而抑制其功能。 ID3能與TCF3（英语：TCF3）（轉錄因子3）發生相互作用。 BTG2（英语：BTG2）能與ID3基因的啓動子結合，進而抑制其ID3基因的活性。如果敲除海馬的BTG2基因的話，海馬ID3表達就會上調，進而使其神經元無法發生末端分化。 DNA結合抑制蛋白（英语：Inhibitor of DNA-binding protein） GRCh38: Ensembl release 89: ENSG00000283060、​ENSG00000117318 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000007872 - Ensembl, May 2017 Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Ellmeier W, Aguzzi A, Kleiner E, Kurzbauer R, Weith A. Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development. EMBO J. Aug 1992, 11 (7): 2563–71. PMC 556731 . 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Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation. J. Biol. Chem. 2002, 277 (11): 9118–26. PMID 11756408. doi:10.1074/jbc.M107713200.  醫學主題詞表（MeSH）：ID3+protein,+human ID3 (基因)引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。