Oct4

Oct4（八聚體結合轉錄因子4, octamer-binding transcription factor 4）,亦稱爲POU5F1（第五類POU結構域轉錄因子1），是一種蛋白質，在人體中由POU5F1基因編碼。Oct4是一種具有與POU結構域（英语：POU domain）同源的結構域的轉錄因子。Oct4對未分化的胚胎幹細胞的自我更新與幹性維持至關重要。也正因如此，有時Oct4會被用來作標記未分化細胞的分子標記。Oct4的過表達或低表達都會造成細胞的分化，因此Oct4只在特定的表達強度下才能維持細胞的幹性。 Oct4（八聚體結合轉錄因子4）名稱中的「八聚體」（octamer）指DNA核苷酸序列「ATTTGCAT」。 Sox2 Nanog 與Oct4相關的疾病；在維基數據上查看/編輯參考.  GRCh38: Ensembl release 89: ENSG00000230336、​ENSG00000206454、​ENSG00000204531、​ENSG00000237582、​ENSG00000229094、​ENSG00000233911、​ENSG00000235068 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000024406 - Ensembl, May 2017 Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Takeda J, Seino S, Bell GI. Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. 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The POU homeodomain protein OCT3 as a potential transcriptional activator for fibroblast growth factor-4 (FGF-4) in human breast cancer cells. The Biochemical Journal. Oct 2003, 375 (Pt 1): 199–205. PMC 1223663 . PMID 12841847. doi:10.1042/BJ20030579.  Reményi A, Lins K, Nissen LJ, Reinbold R, Schöler HR, Wilmanns M. Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. Genes & Development. Aug 2003, 17 (16): 2048–59. PMC 196258 . PMID 12923055. doi:10.1101/gad.269303.  Rajpert-De Meyts E, Hanstein R, Jørgensen N, Graem N, Vogt PH, Skakkebaek NE. Developmental expression of POU5F1 (OCT-3/4) in normal and dysgenetic human gonads. Human Reproduction. Jun 2004, 19 (6): 1338–44. PMID 15105401. doi:10.1093/humrep/deh265.  Matin MM, Walsh JR, Gokhale PJ, Draper JS, Bahrami AR, Morton I, Moore HD, Andrews PW. Specific knockdown of Oct4 and beta2-microglobulin expression by RNA interference in human embryonic stem cells and embryonic carcinoma cells. Stem Cells. 2005, 22 (5): 659–68. PMID 15342930. doi:10.1634/stemcells.22-5-659.  Baal N, Reisinger K, Jahr H, Bohle RM, Liang O, Münstedt K, Rao CV, Preissner KT, Zygmunt MT. Expression of transcription factor Oct-4 and other embryonic genes in CD133 positive cells from human umbilical cord blood. Thrombosis and Haemostasis. Oct 2004, 92 (4): 767–75. PMID 15467907. doi:10.1160/TH04-02-0079.  醫學主題詞表（MeSH）：Oct-4+Transcription+Factor FactorBook POU5F1 Generating iPS Cells from MEFS through Forced Expression of Sox-2, Oct-4, c-Myc, and Klf4（页面存档备份，存于互联网档案馆）