骨骼肌肌动蛋白α1

骨骼肌肌动蛋白α1（英语：Skeletal muscle, actin alpha 1）是一种在人类中由ACTA1基因编码的蛋白质。 在骨骼肌中表达的肌动蛋白α1是已鉴定的六种不同肌动蛋白亚型之一。肌动蛋白是高度保守的蛋白质，它们参与细胞运动、结构和完整性。α肌动蛋白是收缩装置的主要成分。 骨骼α肌动蛋白的表达是由已知会导致肌肉形成的刺激和条件诱导的。这种情况导致定型细胞（卫星细胞）融合到肌管中，形成肌纤维。骨骼肌动蛋白本身在表达时会引起其他几种“生肌基因”的表达，这些基因对肌肉形成至关重要。激活骨骼肌动蛋白基因表达的一个关键转录因子是血清反应因子，一种结合肌动蛋白基因启动子DNA上特定位点的蛋白质。血清反应因子可以将许多其他蛋白质带到骨骼肌动蛋白的启动子，例如雄激素受体，从而有助于通过雄激素（通常称为合成代谢）类固醇诱导骨骼肌动蛋白基因表达。 肌动蛋白α1已被证明与TMSB4X、MIB2和PRKCE产生相互作用。 肌动蛋白 β-肌动蛋白 與骨骼肌肌动蛋白α1相關的疾病；在維基數據上查看/編輯參考.  GRCh38: Ensembl release 89: ENSG00000143632 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000035783 - Ensembl, May 2017 Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Mogensen J, Kruse TA, Børglum AD. Assignment of the human skeletal muscle [FC12]a-actin gene (ACTA1) to chromosome 1q42.13-->q42.2 by radiation hybrid mapping. Cytogenetics and Cell Genetics. 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