鈉氯同向轉運體

鈉氯同向轉運體(sodium-chloride symporter、亦稱為鈉氯協同轉運蛋白(Na+-Cl− cotransporter)、簡稱為NCC或NCCT，或敏感噻嗪類鈉氯協同轉運蛋白(thiazide-sensitive Na+-Cl− cotransporter)、或簡稱TSC，鈉氯離子同向轉運體)是在腎臟的一個協同轉運蛋白(cotransporter)其具有再吸收鈉及氯離子的功能，並從腎小管液進入腎的遠曲小管細胞內。它是"電中性的陽離子結合氯離子的協同轉運蛋白"之SLC12協同轉運蛋白家族的一個成員。在人類中，它是由位於16q13的SLC12A3基因(溶質載體家族12成員的第3)所編碼。 鈉氯同向轉運體或NCC是"電中性的陽離子結合氯離子的協同轉運蛋白"之SLC12協同轉運蛋白家族的一員，伴隨著鉀氯共轉運蛋白(K+-Cl−協同轉運蛋白或KCCs)、鈉鉀氯共轉運蛋白(Na+-K+-Cl−協同轉運蛋白或NKCCs)及孤兒成員CIP(協同轉運蛋白相互作用蛋白)與CCC9。 腎單位 遠曲小管(Distal convoluted tubule) 电解质，如钠及氯化物 協同轉運蛋白(Cotransporter)，包括同向轉運體(symporter) 血壓 利尿劑及噻嗪類(thiazide) Mastroianni N, De Fusco M, Zollo M, Arrigo G, Zuffardi O, Bettinelli A, Ballabio A, Casari G. Molecular cloning, expression pattern, and chromosomal localization of the human Na-Cl thiazide-sensitive cotransporter (SLC12A3). Genomics. August 1996, 35 (3): 486–93. PMID 8812482. doi:10.1006/geno.1996.0388.  Kamdem LK, Hamilton L, Cheng C; et al. Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia. Pharmacogenet. Genomics. 2008, 18 (6): 507–14. PMID 18496130. doi:10.1097/FPC.0b013e3282fc5801.  引文格式1维护：显式使用等标签 (link) Coto E, Arriba G, GarcÃa-Castro M; et al. Clinical and analytical findings in Gitelman's syndrome associated with homozygosity for the c.1925 G>A SLC12A3 mutation. Am. J. Nephrol. 2009, 30 (3): 218–21. PMID 19420906. doi:10.1159/000218104.  引文格式1维护：显式使用等标签 (link) Yasujima M, Tsutaya S. [Mutational analysis of a thiazide-sensitive Na-Cl cotransporter (SLC12A3) gene in a Japanese population—the Iwaki Health Promotion Project]. Rinsho Byori. 2009, 57 (4): 391–6. PMID 19489442.  Shao L, Liu L, Miao Z; et al. A novel SLC12A3 splicing mutation skipping of two exons and preliminary screening for alternative splice variants in human kidney. Am. J. Nephrol. 2008, 28 (6): 900–7. PMID 18580052. doi:10.1159/000141932.  引文格式1维护：显式使用等标签 (link) van Rijn-Bikker PC, Mairuhu G, van Montfrans GA; et al. Genetic factors are relevant and independent determinants of antihypertensive drug effects in a multiracial population. Am. J. Hypertens. 2009, 22 (12): 1295–302. PMID 19779464. doi:10.1038/ajh.2009.192.  引文格式1维护：显式使用等标签 (link) Shao L, Ren H, Wang W; et al. Novel SLC12A3 mutations in Chinese patients with Gitelman's syndrome. Nephron Physiol. 2008, 108 (3): p29–36. PMID 18287808. doi:10.1159/000117815.  引文格式1维护：冗余文本 (link) 引文格式1维护：显式使用等标签 (link) Ji W, Foo JN, O'Roak BJ; et al. Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Nat. Genet. 2008, 40 (5): 592–9. PMC 3766631 . PMID 18391953. doi:10.1038/ng.118.  引文格式1维护：显式使用等标签 (link) Riveira-Munoz E, Devuyst O, Belge H; et al. Evaluating PVALB as a candidate gene for SLC12A3-negative cases of Gitelman's syndrome. Nephrol. Dial. Transplant. 2008, 23 (10): 3120–5. PMID 18469313. doi:10.1093/ndt/gfn229.  引文格式1维护：显式使用等标签 (link) Zhou B, Zhuang J, Gu D; et al. WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway. J. Am. Soc. Nephrol. 2010, 21 (1): 82–92. PMC 2799281 . PMID 19875813. doi:10.1681/ASN.2008121275.  引文格式1维护：显式使用等标签 (link) Hsu YJ, Yang SS, Chu NF; et al. Heterozygous mutations of the sodium chloride cotransporter in Chinese children: prevalence and association with blood pressure. Nephrol. Dial. Transplant. 2009, 24 (4): 1170–5. PMID 19033254. doi:10.1093/ndt/gfn619.  引文格式1维护：显式使用等标签 (link) Nozu K, Iijima K, Nozu Y; et al. A deep intronic mutation in the SLC12A3 gene leads to Gitelman syndrome. Pediatr. Res. 2009, 66 (5): 590–3. PMID 19668106. doi:10.1203/PDR.0b013e3181b9b4d3.  引文格式1维护：显式使用等标签 (link) Ng DP, Nurbaya S, Choo S; et al. Genetic variation at the SLC12A3 locus is unlikely to explain risk for advanced diabetic nephropathy in Caucasians with type 2 diabetes. Nephrol. Dial. Transplant. 2008, 23 (7): 2260–4. PMID 18263927. doi:10.1093/ndt/gfm946.  引文格式1维护：显式使用等标签 (link) Aoi N, Nakayama T, Sato N; et al. Case-control study of the role of the Gitelman's syndrome gene in essential hypertension. Endocr. J. 2008, 55 (2): 305–10. PMID 18362449. doi:10.1507/endocrj.K07E-021.  引文格式1维护：显式使用等标签 (link) Qin L, Shao L, Ren H; et al. Identification of five novel variants in the thiazide-sensitive NaCl co-transporter gene in Chinese patients with Gitelman syndrome. Nephrology (Carlton). 2009, 14 (1): 52–8. PMID 19207868. doi:10.1111/j.1440-1797.2008.01042.x.  引文格式1维护：显式使用等标签 (link) Ridker PM, ParÃ© G, Parker AN; et al. Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health Study. Circ Cardiovasc Genet. 2009, 2 (1): 26–33. PMC 2729193 . PMID 20031564. doi:10.1161/CIRCGENETICS.108.817304.  引文格式1维护：显式使用等标签 (link) Richardson C, Rafiqi FH, Karlsson HK; et al. Activation of the thiazide-sensitive Na+-Cl− cotransporter by the WNK-regulated kinases SPAK and OSR1. J. Cell. Sci. 2008, 121 (Pt 5): 675–84. PMID 18270262. doi:10.1242/jcs.025312.  引文格式1维护：显式使用等标签 (link) Wang XF, Lin RY, Wang SZ; et al. Association study of variants in two ion-channel genes (TSC and CLCNKB) and hypertension in two ethnic groups in Northwest China. Clin. Chim. Acta. 2008, 388 (1–2): 95–8. PMID 17997379. doi:10.1016/j.cca.2007.10.017.  引文格式1维护：显式使用等标签 (link) Miao Z, Gao Y, Bindels RJ; et al. Coexistence of normotensive primary aldosteronism in two patients with Gitelman's syndrome and novel thiazide-sensitive Na–Cl cotransporter mutations. Eur. J. Endocrinol. 2009, 161 (2): 275–83. PMID 19451210. doi:10.1530/EJE-09-0271.  引文格式1维护：显式使用等标签 (link) Zhan YY, Jiang X, Lin G; et al. [Association of thiazide-sensitive Na+-Cl* cotransporter gene polymorphisms with the risk of essential hypertension]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007, 24 (6): 703–5. PMID 18067089.  引文格式1维护：显式使用等标签 (link) 醫學主題詞表（MeSH）：Sodium+Chloride+Symporters 醫學主題詞表（MeSH）：Sodium+Chloride+Symporter+Inhibitors Template:Solute carrier family