甲状腺激素α受体

甲状腺激素α受体（THR-α，TR-α），也称：核受体家族1, A组, 成员1 (NR1A1)，是一类核受体蛋白，在人类中由THR-α基因编码。 该基因编码的蛋白质为三碘甲腺原氨酸的核激素受体。它是甲状腺激素多种受体之一，已被证明可以调节甲状腺激素的生物活性, 小鼠敲除实验表明不同的受体虽然具有一定程度的冗余，但可能介导甲状腺激素的不同功能。 THRA基因突变可能导致甲状腺功能减退症, 一种先天性甲状腺机能低下症亚型。 甲状腺激素受体 α 已被证明与以下存在基因相互作用： COPS2, EP300, ITGB3BP, MED1, MED6, MED12, MED16, MEF2A, NCOA6, TRIP11, UBC. 與甲状腺激素α受体相關的疾病；在維基數據上查看/編輯參考.  對thyroid hormone receptor alpha起作用的藥物；在維基數據上查看/編輯參考.  GRCh38: Ensembl release 89: ENSG00000126351 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000058756 - Ensembl, May 2017 Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Entrez Gene: THRA thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian).  Spurr NK, Solomon E, Jansson M, Sheer D, Goodfellow PN, Bodmer WF, Vennstrom B. 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