肾上腺素受体α1A

肾上腺素受体α1A（α1A adrenoreceptor），又稱為ADRA1A，是一種α1肾上腺素受体（英语：alpha-1 adrenergic receptor）。過去一度有α1C的分類，但在研究後認為α1C僅是α1A的一種亞型，因此取消該命名。為了避免混淆，之後新發現的亞型便從D開始繼續命名。 肾上腺素受体α1共有3種亞型，包含α1A、α1B、α1D，全都屬於Gq/11家族的G蛋白。不同亞型的致活路徑有所差異，本類受體在體內主要內源性配體為腎上腺素，主要產生战斗或逃跑反应。 該蛋白的基因共有四種剪切方式，因此共有四種同型體。不同同型體可由其C端判別，但基本上功能相同。 6-(5-fluoro-2-pyrimidin-5-yl-phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole: EC50 = 1nM, Emax = 65%; good selectivity over α1B, α1D and α2A subtypes further partial agonistic imidazole compounds A-61603 Tamsulosin：用於治療良性前列腺增生症 Silodosin（英语：Silodosin）：用於治療良性前列腺增生症 維思通 WB-4101 Ziprasidone 肾上腺素受体α1A可加強對於樹樹突觸的抑制。 肾上腺素受体 對Adrenoceptor alpha 1A起作用的藥物；在維基數據上查看/編輯參考.  GRCh38: Ensembl release 89: ENSG00000120907 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000045875 - Ensembl, May 2017 Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Mouse PubMed Reference:. 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