甲状腺激素β受体

甲状腺激素β受体（TR-β，或THR-β）也称为核受体亚家族1，A 组，成员2（NR1A2），是一种核受体蛋白，在人类中由THR-β基因编码。 该基因编码的蛋白质为三碘甲腺原氨酸的核激素受体。它是甲状腺激素的多种受体之一，已被证明可以调节甲状腺激素的生物活性。小鼠基因敲除研究表明，不同的受体虽然具有一定程度的冗余，但可能介导甲状腺激素的不同功能。已知该基因的缺陷是导致：广泛性 甲状腺激素抵抗（GTHR）的成因。该综合征疾病的特征为：甲状腺肿大；循环甲状腺激素（T3-T4）水平增加；同时促甲状腺激素（TSH）正常或略微升高。现已发现到该基因的几种转录变体，但迄今为止只观察到一种的全长天然基因。 甲状腺激素β受体已被证明与以下存在基因相互作用： BRD8, CCND1, NCOA1, NCOA6, NCOR2, NR2F6, PPARGC1A, and RXRA. 與甲状腺激素β受体相關的疾病；在維基數據上查看/編輯參考.  對Thyroid hormone receptor beta起作用的藥物；在維基數據上查看/編輯參考.  GRCh38: Ensembl release 89: ENSG00000151090 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000021779 - Ensembl, May 2017 Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Entrez Gene: THRA thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian).  Sakurai A, Nakai A, DeGroot LJ. 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