脂联素受体1

脂联素受体1（英語：Adiponectin receptor 1，缩写ADIPOR1）是一种由人类基因 ADIPOR1 编码的蛋白质。 ADIPOR1和G蛋白偶联受体（GPCRs）类似，都拥有7个跨膜结构域（英语：transmembrane domain）。但是ADIPOR1的七跨膜的位置与GPCRs相反，N-端在细胞内，C-端在细胞外，也不能与G蛋白相互作用。 脂联素的受体，ADIPOR1和ADIPOR2，能应答球状或全长的脂联素信号，促使AMPK（英语：AMP-activated protein kinase）和PPAR-α（英语：Peroxisome proliferator-activated receptor alpha）配体活性增加，以及脂肪酸的氧化和葡萄糖摄取。 Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. June 2003, 423 (6941): 762–9. PMID 12802337. doi:10.1038/nature01705.  Entrez Gene: ADIPOR1 adiponectin receptor 1.  Crimmins NA, Martin LJ. Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance.. 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