主要碱性蛋白

主要碱性蛋白（英語：Major basic protein，MBP），全称为嗜酸性粒细胞主要碱性蛋白（英語：Eosinophil Major basic protein），也称为蛋白多糖2（Proteoglycan 2，PRG2），是一种由人类基因PRG2编码的蛋白质。 MBP在结构上类似于凝集素（糖结合蛋白），特别是与C-型凝集素在折叠上相似。但与C-型凝集素不同（C-型凝集素在钙的存在下会结合各种碳水化合物），MBP既不与钙结合也不与这些糖类结合，而是识别並結合硫酸乙酰肝素（heparan sulfate）。MBP的两种晶体结构已被测定。 主要碱性蛋白已知可与妊娠相关血浆蛋白A发生蛋白質交互作用。 GRCh38: Ensembl release 89: ENSG00000186652 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000027073 - Ensembl, May 2017 Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Entrez Gene: PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein). （原始内容存档于2008-11-02）.  PDB 1h8u; Swaminathan GJ, Weaver AJ, Loegering DA, Checkel JL, Leonidas DD, Gleich GJ, Acharya KR. Crystal structure of the eosinophil major basic protein at 1.8 A. 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