A20 (基因)

A20基因（或称为：肿瘤坏死因子α诱导蛋白3，英語：Tumor necrosis factor, alpha-induced protein 3，缩写TNFAIP3）是人类六号染色体上的基因，可由肿瘤坏死因子α（TNF-α）诱导表达，是一种去泛素化酶和锌指蛋白，可抑制NF-κB激活和TNF介导的细胞凋亡。A20是一种非常古老的蛋白，在刺胞動物門（水母）中也有带有同源结构域的蛋白。 A20蛋白与下列蛋白質进行互作：TNIP1、TRAF1、TRAF2、IKBKG、TAX1BP1、YWHAB、YWHAZ、TRAF6和YWHAH。 與A20相關的疾病；在維基數據上查看/編輯參考.  GRCh38: Ensembl release 89: ENSG00000118503 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000019850 - Ensembl, May 2017 Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Opipari AW Jr; Boguski MS; Dixit VM. The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. J Biol Chem. October 1990, 265 (25): 14705–8. PMID 2118515.  Entrez Gene: TNFAIP3 tumor necrosis factor, alpha-induced protein 3. （原始内容存档于2010-12-05）.  Staal J, Driege Y, Haegman M, Borghi A, Hulpiau P, Lievens L, et al. Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions. Frontiers in Immunology. 2018, 9: 1136. PMC 5978004 . PMID 29881386. doi:10.3389/fimmu.2018.01136.  Heyninck, K; De Valck D; Vanden Berghe W; Van Criekinge W; Contreras R; Fiers W; Haegeman G; Beyaert R. The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. J. Cell Biol. (UNITED STATES). June 1999, 145 (7): 1471–82. ISSN 0021-9525. PMC 2133159 . PMID 10385526. doi:10.1083/jcb.145.7.1471.  Song, H Y; Rothe M; Goeddel D V. The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). June 1996, 93 (13): 6721–5. Bibcode:1996PNAS...93.6721S. ISSN 0027-8424. PMC 39093 . PMID 8692885. doi:10.1073/pnas.93.13.6721.  Heyninck, K; Beyaert R. The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6. FEBS Lett. (NETHERLANDS). January 1999, 442 (2–3): 147–50. ISSN 0014-5793. PMID 9928991. S2CID 19072203. doi:10.1016/S0014-5793(98)01645-7.  Zhang, S Q; Kovalenko A; Cantarella G; Wallach D. Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation. Immunity (UNITED STATES). March 2000, 12 (3): 301–11. ISSN 1074-7613. PMID 10755617. doi:10.1016/S1074-7613(00)80183-1.  De Valck, D; Jin D Y; Heyninck K; Van de Craen M; Contreras R; Fiers W; Jeang K T; Beyaert R. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene (ENGLAND). July 1999, 18 (29): 4182–90. ISSN 0950-9232. PMID 10435631. doi:10.1038/sj.onc.1202787 .  Vincenz, C; Dixit V M. 14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules. J. Biol. Chem. (UNITED STATES). August 1996, 271 (33): 20029–34. ISSN 0021-9258. PMID 8702721. doi:10.1074/jbc.271.33.20029 .  De Valck, D; Heyninck K; Van Criekinge W; Vandenabeele P; Fiers W; Beyaert R. A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins. Biochem. Biophys. Res. Commun. (UNITED STATES). September 1997, 238 (2): 590–4. ISSN 0006-291X. PMID 9299557. doi:10.1006/bbrc.1997.7343.  Evans, P C; Taylor E R; Coadwell J; Heyninck K; Beyaert R; Kilshaw P J. Isolation and characterization of two novel A20-like proteins. Biochem. J. (England). August 2001, 357 (Pt 3): 617–23. ISSN 0264-6021. PMC 1221992 . PMID 11463333. doi:10.1042/0264-6021:3570617.  PDB中UniProt可用的所有結構信息之概述：P21580 (Tumor necrosis factor alpha-induced protein 3) 在PDBe-KB（英语：PDBe-KB）。