內輸蛋白亞基α-2

內輸蛋白亞基α-2（英語：Importin subunit alpha-2）是人體內的一種蛋白質，為內輸蛋白α（英语：Importin α）的一種，由17號染色體上的KPNA2基因編碼。 內輸蛋白亞基α-2參與了蛋白質由細胞質轉運進細胞核的過程，細胞質中，內輸蛋白α可結合具有核定位序列的蛋白質，接著再與內輸蛋白β結合而形成二聚體，後者可與核孔複合物互動，使二聚體和蛋白質一起進入細胞核中。入核後，內輸蛋白二聚體與Ran-GTP結合而將原本結合的蛋白質釋出，再回到細胞質中。此過程與Ran循環（英语：Ran (protein)）偶連，並需消耗能量。 除了協助蛋白質進入細胞核外，KPNA2可能也參與V(D)J重組（英语：V(D)J recombination）。 核轉運蛋白α-2會與以下的蛋白質產生交互作用： ADP-核糖基化因子樣蛋白4A（英语：ARL4A） 白細胞介素-2誘導性T細胞激酶（英语：ITK (gene)） 內輸蛋白亞基b-1（英语：KPNB1） 鋅指蛋白PLAG1（英语：PLAG1） ATP依賴性DNA螺旋酶Q1（英语：RECQL） 絲氨酸/蘇氨酸蛋白激酶（英语：SGK） GRCh38: Ensembl release 89: ENSG00000182481 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000018362 - Ensembl, May 2017 Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.  Cuomo CA, Kirch SA, Gyuris J, Brent R, Oettinger MA. Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein. 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