Brad, I am thinking that since remote proxies are re-created on every request by CF, this might incur locking issues, where multiple requests could be registering new instances.  I think maybe the approach would be similar to what the ORM Event Handler does:

----
getWireBox().autowire(target=entity,targetID="ORMEntity-#entityName#");

We can pass the path as the id: replaceNoCase(mid(cgi.script_name,2,len(cgi.script_name)-5),'/','.');